Pathway Name	Avg Num Perturbations	Total Perturbations	Num Entities	Min Mean Truth	Max Mean Truth	Min Mean Within	Max Mean Within	Min Mean Any	Max Mean Within
TCGA08_retinoblastoma	49.0	393.0	8.0	-0.12	0.065	1000.0	-1000.0	-0.018	-1000.0
FOXA2 and FOXA3 transcription factor networks	37.0	1724.0	46.0	-0.53	0.011	1000.0	-1000.0	-0.085	-1000.0
IL23-mediated signaling events	37.0	2225.0	60.0	-0.484	0.012	1000.0	-1000.0	-0.156	-1000.0
Syndecan-1-mediated signaling events	36.0	1240.0	34.0	-0.204	0.012	1000.0	-1000.0	-0.049	-1000.0
IL4-mediated signaling events	34.0	3127.0	91.0	-0.725	0.586	1000.0	-1000.0	-0.168	-1000.0
Signaling events regulated by Ret tyrosine kinase	33.0	2756.0	82.0	-0.183	0.012	1000.0	-1000.0	-0.078	-1000.0
TCR signaling in naïve CD8+ T cells	32.0	3062.0	93.0	-0.201	0.028	1000.0	-1000.0	-0.077	-1000.0
Glypican 2 network	30.0	120.0	4.0	-0.046	-0.043	1000.0	-1000.0	-0.021	-1000.0
Wnt signaling	29.0	209.0	7.0	-0.141	0.009	1000.0	-1000.0	-0.034	-1000.0
Signaling events mediated by the Hedgehog family	26.0	1392.0	52.0	-0.258	0.096	1000.0	-1000.0	-0.046	-1000.0
IL12-mediated signaling events	25.0	2221.0	87.0	-0.288	0.055	1000.0	-1000.0	-0.127	-1000.0
Reelin signaling pathway	25.0	1429.0	56.0	-0.222	0.029	1000.0	-1000.0	-0.066	-1000.0
TCGA08_p53	24.0	174.0	7.0	-0.095	0.058	1000.0	-1000.0	-0.016	-1000.0
Noncanonical Wnt signaling pathway	23.0	609.0	26.0	-0.141	0.012	1000.0	-1000.0	-0.052	-1000.0
amb2 Integrin signaling	23.0	1922.0	82.0	-0.232	0.015	1000.0	-1000.0	-0.069	-1000.0
Ephrin B reverse signaling	23.0	1108.0	48.0	-0.156	0.016	1000.0	-1000.0	-0.06	-1000.0
BCR signaling pathway	22.0	2205.0	99.0	-0.202	0.017	1000.0	-1000.0	-0.081	-1000.0
Nephrin/Neph1 signaling in the kidney podocyte	21.0	714.0	34.0	-0.116	0.012	1000.0	-1000.0	-0.044	-1000.0
p75(NTR)-mediated signaling	21.0	2706.0	125.0	-0.229	0.034	1000.0	-1000.0	-0.096	-1000.0
Glypican 1 network	21.0	1023.0	48.0	-0.194	0.022	1000.0	-1000.0	-0.036	-1000.0
Calcineurin-regulated NFAT-dependent transcription in lymphocytes	21.0	1438.0	68.0	-0.281	0.109	1000.0	-1000.0	-0.132	-1000.0
Caspase cascade in apoptosis	20.0	1523.0	74.0	-0.168	0.061	1000.0	-1000.0	-0.036	-1000.0
RXR and RAR heterodimerization with other nuclear receptor	19.0	992.0	52.0	-0.25	0.039	1000.0	-1000.0	-0.048	-1000.0
Endothelins	19.0	1896.0	96.0	-0.161	0.012	1000.0	-1000.0	-0.087	-1000.0
Signaling mediated by p38-alpha and p38-beta	19.0	877.0	44.0	-0.113	0.012	1000.0	-1000.0	-0.044	-1000.0
Syndecan-4-mediated signaling events	19.0	1327.0	67.0	-0.151	0.016	1000.0	-1000.0	-0.079	-1000.0
BMP receptor signaling	18.0	1533.0	81.0	-0.221	0.036	1000.0	-1000.0	-0.089	-1000.0
Glucocorticoid receptor regulatory network	18.0	2113.0	114.0	-0.426	0.245	1000.0	-1000.0	-0.076	-1000.0
Effects of Botulinum toxin	18.0	484.0	26.0	-0.174	0.014	1000.0	-1000.0	-0.057	-1000.0
Visual signal transduction: Rods	18.0	986.0	52.0	-0.162	0.012	1000.0	-1000.0	-0.077	-1000.0
Class IB PI3K non-lipid kinase events	18.0	54.0	3.0	-0.021	-1000.0	1000.0	-1000.0	-0.012	-1000.0
LPA4-mediated signaling events	17.0	205.0	12.0	-0.129	0.016	1000.0	-1000.0	-0.027	-1000.0
Visual signal transduction: Cones	17.0	665.0	38.0	-0.107	0.012	1000.0	-1000.0	-0.058	-1000.0
Thromboxane A2 receptor signaling	17.0	1838.0	105.0	-0.115	0.029	1000.0	-1000.0	-0.07	-1000.0
HIF-1-alpha transcription factor network	15.0	1179.0	76.0	-0.255	0.037	1000.0	-1000.0	-0.189	-1000.0
Fc-epsilon receptor I signaling in mast cells	15.0	1484.0	97.0	-0.133	0.027	1000.0	-1000.0	-0.074	-1000.0
Nongenotropic Androgen signaling	15.0	788.0	52.0	-0.098	0.014	1000.0	-1000.0	-0.049	-1000.0
Neurotrophic factor-mediated Trk receptor signaling	15.0	1842.0	120.0	-0.232	0.074	1000.0	-1000.0	-0.067	-1000.0
Ephrin A  reverse signaling	14.0	103.0	7.0	-0.02	-0.0	1000.0	-1000.0	-0.02	-1000.0
JNK signaling in the CD4+ TCR pathway	14.0	242.0	17.0	-0.068	0.012	1000.0	-1000.0	-0.041	-1000.0
Retinoic acid receptors-mediated signaling	14.0	819.0	58.0	-0.224	0.024	1000.0	-1000.0	-0.065	-1000.0
Calcium signaling in the CD4+ TCR pathway	14.0	450.0	31.0	-0.128	0.012	1000.0	-1000.0	-0.077	-1000.0
EGFR-dependent Endothelin signaling events	14.0	302.0	21.0	-0.082	0.017	1000.0	-1000.0	-0.066	-1000.0
ErbB2/ErbB3 signaling events	13.0	878.0	65.0	-0.16	0.017	1000.0	-1000.0	-0.064	-1000.0
Osteopontin-mediated events	13.0	503.0	38.0	-0.091	0.014	1000.0	-1000.0	-0.083	-1000.0
Lissencephaly gene (LIS1) in neuronal migration and development	13.0	734.0	54.0	-0.181	0.023	1000.0	-1000.0	-0.086	-1000.0
IL27-mediated signaling events	13.0	679.0	51.0	-0.118	0.046	1000.0	-1000.0	-0.058	-1000.0
ErbB4 signaling events	12.0	875.0	69.0	-0.195	0.132	1000.0	-1000.0	-0.086	-1000.0
Signaling events mediated by PTP1B	12.0	923.0	76.0	-0.101	0.034	1000.0	-1000.0	-0.073	-1000.0
Syndecan-3-mediated signaling events	12.0	448.0	35.0	-0.147	0.034	1000.0	-1000.0	-0.041	-1000.0
Signaling events mediated by Stem cell factor receptor (c-Kit)	12.0	948.0	78.0	-0.068	0.051	1000.0	-1000.0	-0.075	-1000.0
Coregulation of Androgen receptor activity	11.0	885.0	76.0	-0.19	0.024	1000.0	-1000.0	-0.039	-1000.0
PDGFR-alpha signaling pathway	11.0	516.0	44.0	-0.081	0.02	1000.0	-1000.0	-0.064	-1000.0
FAS signaling pathway (CD95)	11.0	556.0	47.0	-0.128	0.013	1000.0	-1000.0	-0.039	-1000.0
Integrins in angiogenesis	11.0	934.0	84.0	-0.094	0.02	1000.0	-1000.0	-0.079	-1000.0
EPHB forward signaling	11.0	977.0	85.0	-0.072	0.064	1000.0	-1000.0	-0.084	-1000.0
BARD1 signaling events	10.0	573.0	57.0	-0.053	0.043	1000.0	-1000.0	-0.061	-1000.0
Arf6 signaling events	10.0	665.0	62.0	-0.094	0.027	1000.0	-1000.0	-0.057	-1000.0
Signaling events activated by Hepatocyte Growth Factor Receptor (c-Met)	10.0	934.0	85.0	-0.075	0.019	1000.0	-1000.0	-0.071	-1000.0
LPA receptor mediated events	10.0	1107.0	102.0	-0.1	0.03	1000.0	-1000.0	-0.086	-1000.0
Ras signaling in the CD4+ TCR pathway	10.0	173.0	17.0	-0.041	0.014	1000.0	-1000.0	-0.036	-1000.0
Regulation of nuclear SMAD2/3 signaling	9.0	1279.0	136.0	-0.303	0.121	1000.0	-1000.0	-0.071	-1000.0
Syndecan-2-mediated signaling events	9.0	684.0	69.0	-0.087	0.03	1000.0	-1000.0	-0.031	-1000.0
Nectin adhesion pathway	9.0	580.0	63.0	-0.054	0.019	1000.0	-1000.0	-0.063	-1000.0
Signaling events mediated by HDAC Class III	9.0	389.0	40.0	-0.163	0.069	1000.0	-1000.0	-0.035	-1000.0
TRAIL signaling pathway	9.0	435.0	48.0	-0.038	0.024	1000.0	-1000.0	-0.068	-1000.0
IL1-mediated signaling events	9.0	618.0	62.0	-0.082	0.05	1000.0	-1000.0	-0.085	-1000.0
IL2 signaling events mediated by PI3K	9.0	528.0	58.0	-0.062	0.028	1000.0	-1000.0	-0.076	-1000.0
HIV-1 Nef: Negative effector of Fas and TNF-alpha	9.0	434.0	45.0	-0.096	0.026	1000.0	-1000.0	-0.079	-1000.0
IL6-mediated signaling events	9.0	747.0	75.0	-0.12	0.042	1000.0	-1000.0	-0.079	-1000.0
IL2 signaling events mediated by STAT5	9.0	207.0	22.0	-0.061	0.012	1000.0	-1000.0	-0.055	-1000.0
Plasma membrane estrogen receptor signaling	9.0	834.0	86.0	-0.098	0.021	1000.0	-1000.0	-0.076	-1000.0
Angiopoietin receptor Tie2-mediated signaling	9.0	875.0	88.0	-0.115	0.023	1000.0	-1000.0	-0.097	-1000.0
Hypoxic and oxygen homeostasis regulation of HIF-1-alpha	9.0	321.0	33.0	-0.13	0.033	1000.0	-1000.0	-0.039	-1000.0
Regulation of Androgen receptor activity	9.0	661.0	70.0	-0.249	0.024	1000.0	-1000.0	-0.065	-1000.0
Cellular roles of Anthrax toxin	8.0	325.0	39.0	-0.084	0.013	1000.0	-1000.0	-0.02	-1000.0
Canonical Wnt signaling pathway	8.0	456.0	51.0	-0.14	0.05	1000.0	-1000.0	-0.059	-1000.0
FOXM1 transcription factor network	8.0	423.0	51.0	-0.131	0.113	1000.0	-1000.0	-0.191	-1000.0
Presenilin action in Notch and Wnt signaling	7.0	477.0	61.0	-0.128	0.034	1000.0	-1000.0	-0.07	-1000.0
S1P5 pathway	7.0	135.0	17.0	-0.098	0.021	1000.0	-1000.0	-0.037	-1000.0
S1P1 pathway	7.0	269.0	36.0	-0.098	0.012	1000.0	-1000.0	-0.056	-1000.0
IGF1 pathway	7.0	435.0	57.0	-0.026	0.024	1000.0	-1000.0	-0.077	-1000.0
Sphingosine 1-phosphate (S1P) pathway	6.0	180.0	28.0	-0.098	0.019	1000.0	-1000.0	-0.037	-1000.0
a4b1 and a4b7 Integrin signaling	6.0	30.0	5.0	-0.005	0.006	1000.0	-1000.0	-0.021	-1000.0
Aurora C signaling	6.0	45.0	7.0	-0.041	0.004	1000.0	-1000.0	-0.026	-1000.0
Ceramide signaling pathway	6.0	473.0	76.0	-0.077	0.032	1000.0	-1000.0	-0.032	-1000.0
Regulation of p38-alpha and p38-beta	6.0	328.0	54.0	-0.106	0.03	1000.0	-1000.0	-0.057	-1000.0
TCGA08_rtk_signaling	6.0	174.0	26.0	-0.045	0.031	1000.0	-1000.0	-0.02	-1000.0
Stabilization and expansion of the E-cadherin adherens junction	6.0	464.0	74.0	-0.076	0.06	1000.0	-1000.0	-0.081	-1000.0
Regulation of Telomerase	6.0	617.0	102.0	-0.147	0.033	1000.0	-1000.0	-0.097	-1000.0
S1P4 pathway	6.0	164.0	25.0	-0.098	0.019	1000.0	-1000.0	-0.037	-1000.0
Hedgehog signaling events mediated by Gli proteins	5.0	351.0	65.0	-0.235	0.039	1000.0	-1000.0	-0.061	-1000.0
Aurora A signaling	5.0	339.0	60.0	-0.112	0.028	1000.0	-1000.0	-0.039	-1000.0
Paxillin-independent events mediated by a4b1 and a4b7	5.0	211.0	37.0	-0.048	0.021	1000.0	-1000.0	-0.049	-1000.0
Class I PI3K signaling events	5.0	424.0	73.0	-0.076	0.027	1000.0	-1000.0	-0.07	-1000.0
S1P3 pathway	5.0	237.0	42.0	-0.098	0.017	1000.0	-1000.0	-0.048	-1000.0
Signaling events mediated by PRL	5.0	176.0	34.0	-0.099	0.021	1000.0	-1000.0	-0.04	-1000.0
EPO signaling pathway	4.0	230.0	55.0	-0.019	0.047	1000.0	-1000.0	-0.087	-1000.0
IFN-gamma pathway	4.0	291.0	68.0	-0.094	0.039	1000.0	-1000.0	-0.089	-1000.0
ceramide signaling pathway	4.0	223.0	49.0	-0.077	0.021	1000.0	-1000.0	-0.04	-1000.0
Rapid glucocorticoid signaling	4.0	86.0	20.0	-0.027	0.013	1000.0	-1000.0	-0.015	-1000.0
Aurora B signaling	4.0	288.0	67.0	-0.089	0.02	1000.0	-1000.0	-0.062	-1000.0
Canonical NF-kappaB pathway	3.0	124.0	39.0	-0.077	0.06	1000.0	-1000.0	-0.079	-1000.0
HIF-2-alpha transcription factor network	3.0	152.0	43.0	-0.071	0.072	1000.0	-1000.0	-0.081	-1000.0
Role of Calcineurin-dependent NFAT signaling in lymphocytes	3.0	321.0	83.0	-0.169	0.044	1000.0	-1000.0	-0.072	-1000.0
Signaling events mediated by HDAC Class I	3.0	349.0	104.0	-0.077	0.045	1000.0	-1000.0	-0.061	-1000.0
Signaling mediated by p38-gamma and p38-delta	3.0	54.0	15.0	-0.03	0.024	1000.0	-1000.0	-0.023	-1000.0
Paxillin-dependent events mediated by a4b1	3.0	130.0	36.0	-0.048	0.026	1000.0	-1000.0	-0.064	-1000.0
E-cadherin signaling in the nascent adherens junction	3.0	282.0	76.0	-0.045	0.038	1000.0	-1000.0	-0.073	-1000.0
Insulin Pathway	3.0	230.0	74.0	-0.115	0.03	1000.0	-1000.0	-0.081	-1000.0
PDGFR-beta signaling pathway	3.0	311.0	97.0	-0.046	0.042	1000.0	-1000.0	-0.073	-1000.0
E-cadherin signaling in keratinocytes	3.0	143.0	43.0	-0.04	0.033	1000.0	-1000.0	-0.054	-1000.0
E-cadherin signaling events	3.0	15.0	5.0	-0.001	0.015	1000.0	-1000.0	-0.018	-1000.0
p38 MAPK signaling pathway	3.0	157.0	44.0	-0.094	0.024	1000.0	-1000.0	-0.064	-1000.0
Signaling events mediated by HDAC Class II	2.0	220.0	75.0	-0.046	0.034	1000.0	-1000.0	-0.041	-1000.0
PLK2 and PLK4 events	2.0	8.0	3.0	0.002	0.012	1000.0	-1000.0	-0.019	-1000.0
Arf6 downstream pathway	2.0	90.0	43.0	-0.02	0.021	1000.0	-1000.0	-0.034	-1000.0
PLK1 signaling events	2.0	184.0	85.0	-0.014	0.028	1000.0	-1000.0	-0.036	-1000.0
FoxO family signaling	2.0	186.0	64.0	-0.113	0.086	1000.0	-1000.0	-0.064	-1000.0
Atypical NF-kappaB pathway	2.0	90.0	31.0	-0.03	0.028	1000.0	-1000.0	-0.035	-1000.0
Circadian rhythm pathway	1.0	43.0	22.0	-0.026	0.031	1000.0	-1000.0	-0.048	-1000.0
Insulin-mediated glucose transport	1.0	57.0	32.0	-0.04	0.024	1000.0	-1000.0	-0.055	-1000.0
mTOR signaling pathway	1.0	76.0	53.0	-0.004	0.028	1000.0	-1000.0	-0.053	-1000.0
Class I PI3K signaling events mediated by Akt	1.0	90.0	68.0	-0.04	0.042	1000.0	-1000.0	-0.04	-1000.0
Signaling events mediated by VEGFR1 and VEGFR2	1.0	249.0	125.0	-0.054	0.067	1000.0	-1000.0	-0.095	-1000.0
Arf6 trafficking events	1.0	77.0	71.0	-0.058	0.037	1000.0	-1000.0	-0.069	-1000.0
VEGFR1 specific signals	1.0	91.0	56.0	-0.01	0.044	1000.0	-1000.0	-0.058	-1000.0
Regulation of cytoplasmic and nuclear SMAD2/3 signaling	0.0	10.0	23.0	0.006	0.036	1000.0	-1000.0	-0.054	-1000.0
Sumoylation by RanBP2 regulates transcriptional repression	0.0	2.0	27.0	0.0	0.028	1000.0	-1000.0	-0.05	-1000.0
Arf1 pathway	0.0	12.0	54.0	-0.0	0.026	1000.0	-1000.0	-0.034	-1000.0
Alternative NF-kappaB pathway	0.0	7.0	13.0	-0.0	0.033	1000.0	-1000.0	-0.03	-1000.0
Total	1501	87010	7203	-15.7559476554	-995.117785792	131000	-131000	-8.09908614089	-131000