E-cadherin signaling in the nascent adherens junction Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations CTTN -0.012 0.103 -9999.0 0.0 -0.38 8.0 8.0 KLHL20 -0.007 0.091 0.173 1.0 -0.247 17.0 18.0 CYFIP2 0.028 0.005 -9999.0 0.0 -9999.0 0.0 0.0 Rac1/GDP 0.012 0.08 0.267 3.0 -0.281 3.0 6.0 ENAH -0.012 0.105 -9999.0 0.0 -0.38 8.0 8.0 AP1M1 0.025 0.01 -9999.0 0.0 -9999.0 0.0 0.0 RAP1B 0.028 0.006 -9999.0 0.0 -9999.0 0.0 0.0 RAP1A 0.029 0.004 -9999.0 0.0 -9999.0 0.0 0.0 CTNNB1 0.029 0.003 -9999.0 0.0 -9999.0 0.0 0.0 CDC42/GTP 0.019 0.047 -9999.0 0.0 -0.218 4.0 4.0 ABI1/Sra1/Nap1 -0.024 0.051 -9999.0 0.0 -0.168 17.0 17.0 E-cadherin/beta catenin/alpha catenin/beta7/alphaE Integrin 0.051 0.07 -9999.0 0.0 -0.288 9.0 9.0 RAPGEF1 -0.005 0.096 0.274 3.0 -0.354 6.0 9.0 CTNND1 0.029 0.003 -9999.0 0.0 -9999.0 0.0 0.0 regulation of calcium-dependent cell-cell adhesion -0.005 0.111 -9999.0 0.0 -0.387 8.0 8.0 CRK -0.004 0.093 -9999.0 0.0 -0.368 7.0 7.0 E-cadherin/gamma catenin/alpha catenin 0.045 0.05 -9999.0 0.0 -0.307 4.0 4.0 alphaE/beta7 Integrin 0.033 0.055 -9999.0 0.0 -0.355 5.0 5.0 IQGAP1 0.028 0.005 -9999.0 0.0 -9999.0 0.0 0.0 NCKAP1 0.029 0.004 -9999.0 0.0 -9999.0 0.0 0.0 Rap1/GTP/I-afadin 0.047 0.029 -9999.0 0.0 -0.279 1.0 1.0 DLG1 -0.009 0.095 -9999.0 0.0 -0.359 8.0 8.0 ChemicalAbstracts:7440-70-2 -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 mol:PI-3-4-5-P3 -0.012 0.02 -9999.0 0.0 -0.162 2.0 2.0 MLLT4 0.025 0.033 -9999.0 0.0 -0.493 1.0 1.0 ARF6/GTP/NME1/Tiam1 0.048 0.039 -9999.0 0.0 -0.279 3.0 3.0 PI3K -0.001 0.03 -9999.0 0.0 -9999.0 0.0 0.0 ARF6 0.029 0.004 -9999.0 0.0 -9999.0 0.0 0.0 mol:Ca2+ -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/gamma catenin 0.032 0.052 -9999.0 0.0 -0.359 4.0 4.0 TIAM1 0.022 0.056 -9999.0 0.0 -0.493 3.0 3.0 E-cadherin(dimer)/Ca2+ 0.054 0.048 -9999.0 0.0 -0.266 4.0 4.0 AKT1 0.005 0.04 0.162 2.0 -9999.0 0.0 2.0 PIK3R1 0.026 0.011 -9999.0 0.0 -9999.0 0.0 0.0 CDH1 0.018 0.065 -9999.0 0.0 -0.493 4.0 4.0 RhoA/GDP 0.015 0.081 0.267 3.0 -0.278 3.0 6.0 actin cytoskeleton organization -0.003 0.068 0.142 1.0 -0.181 16.0 17.0 CDC42/GDP 0.016 0.081 0.267 3.0 -0.278 3.0 6.0 E-cadherin/Ca2+/gamma catenin/alpha catenin/p120 catenin 0.014 0.036 -9999.0 0.0 -0.24 4.0 4.0 ITGB7 0.019 0.072 -9999.0 0.0 -0.493 5.0 5.0 RAC1 0.028 0.007 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/beta catenin/alpha catenin/p120 catenin 0.059 0.051 -9999.0 0.0 -0.282 4.0 4.0 E-cadherin/Ca2+/beta catenin/alpha catenin 0.04 0.043 -9999.0 0.0 -0.262 4.0 4.0 mol:GDP -0.0 0.085 0.272 3.0 -0.318 3.0 6.0 CDC42/GTP/IQGAP1 0.037 0.009 -9999.0 0.0 -9999.0 0.0 0.0 JUP 0.028 0.006 -9999.0 0.0 -9999.0 0.0 0.0 p120 catenin/RhoA/GDP 0.024 0.084 0.265 3.0 -0.285 3.0 6.0 RAC1/GTP/IQGAP1 0.036 0.011 -9999.0 0.0 -9999.0 0.0 0.0 PIP5K1C/AP1M1 0.035 0.017 -9999.0 0.0 -9999.0 0.0 0.0 RHOA 0.029 0.002 -9999.0 0.0 -9999.0 0.0 0.0 CDC42 0.029 0.004 -9999.0 0.0 -9999.0 0.0 0.0 CTNNA1 0.029 0.004 -9999.0 0.0 -9999.0 0.0 0.0 positive regulation of S phase of mitotic cell cycle -0.01 0.075 0.128 2.0 -0.212 26.0 28.0 NME1 0.028 0.006 -9999.0 0.0 -9999.0 0.0 0.0 clathrin coat assembly -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 TJP1 -0.007 0.097 -9999.0 0.0 -0.395 6.0 6.0 regulation of cell-cell adhesion 0.006 0.035 -9999.0 0.0 -0.193 4.0 4.0 WASF2 -0.001 0.035 -9999.0 0.0 -0.123 3.0 3.0 Rap1/GTP 0.02 0.058 0.273 2.0 -0.24 4.0 6.0 E-cadherin/gamma catenin/alpha catenin/beta7/alphaE Integrin 0.06 0.072 -9999.0 0.0 -0.274 9.0 9.0 CCND1 -0.014 0.093 0.147 2.0 -0.265 26.0 28.0 VAV2 -0.015 0.173 -9999.0 0.0 -0.617 14.0 14.0 RAP1/GDP 0.023 0.067 0.289 2.0 -0.244 3.0 5.0 adherens junction assembly -0.007 0.094 -9999.0 0.0 -0.383 6.0 6.0 homophilic cell adhesion -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ABI1 0.029 0.004 -9999.0 0.0 -9999.0 0.0 0.0 PIP5K1C 0.026 0.009 -9999.0 0.0 -9999.0 0.0 0.0 regulation of heterotypic cell-cell adhesion 0.043 0.065 -9999.0 0.0 -0.265 9.0 9.0 E-cadherin/beta catenin 0.006 0.038 -9999.0 0.0 -0.279 4.0 4.0 mol:GTP -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 SRC -0.01 0.102 -9999.0 0.0 -0.38 8.0 8.0 PIK3CA 0.023 0.012 -9999.0 0.0 -9999.0 0.0 0.0 Rac1/GTP -0.044 0.13 -9999.0 0.0 -0.408 18.0 18.0 E-cadherin/beta catenin/alpha catenin 0.045 0.05 -9999.0 0.0 -0.308 4.0 4.0 ITGAE 0.028 0.007 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin -0.005 0.112 -9999.0 0.0 -0.395 8.0 8.0