Signaling events mediated by the Hedgehog family Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations TGFB2 -0.019 0.184 -9999.0 0.0 -0.674 18.0 18.0 IHH 0.022 0.059 -9999.0 0.0 -0.524 1.0 1.0 SHH Np/Cholesterol/GAS1 -0.02 0.108 -9999.0 0.0 -0.306 30.0 30.0 LRPAP1 0.028 0.007 -9999.0 0.0 -9999.0 0.0 0.0 dorsoventral neural tube patterning 0.02 0.108 0.304 30.0 -9999.0 0.0 30.0 SMO/beta Arrestin2 0.017 0.102 -9999.0 0.0 -0.378 6.0 6.0 SMO -0.004 0.1 -9999.0 0.0 -0.394 7.0 7.0 AKT1 -0.0 0.078 -9999.0 0.0 -0.305 3.0 3.0 ARRB2 0.028 0.006 -9999.0 0.0 -9999.0 0.0 0.0 BOC 0.02 0.057 -9999.0 0.0 -0.493 3.0 3.0 ADRBK1 0.029 0.004 -9999.0 0.0 -9999.0 0.0 0.0 heart looping -0.003 0.099 -9999.0 0.0 -0.389 7.0 7.0 STIL -0.023 0.113 -9999.0 0.0 -0.305 19.0 19.0 DHH N/PTCH2 0.014 0.097 -9999.0 0.0 -0.359 16.0 16.0 DHH N/PTCH1 0.01 0.107 -9999.0 0.0 -0.312 24.0 24.0 PIK3CA 0.023 0.012 -9999.0 0.0 -9999.0 0.0 0.0 DHH 0.013 0.085 -9999.0 0.0 -0.493 7.0 7.0 PTHLH -0.023 0.191 -9999.0 0.0 -0.693 17.0 17.0 determination of left/right symmetry -0.003 0.099 -9999.0 0.0 -0.389 7.0 7.0 PIK3R1 0.026 0.011 -9999.0 0.0 -9999.0 0.0 0.0 skeletal system development -0.023 0.189 -9999.0 0.0 -0.685 17.0 17.0 IHH N/Hhip -0.0 0.121 -9999.0 0.0 -0.389 21.0 21.0 DHH N/Hhip -0.003 0.125 -9999.0 0.0 -0.371 26.0 26.0 mol:Cholesterol -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 heart development -0.003 0.099 -9999.0 0.0 -0.389 7.0 7.0 pancreas development -0.02 0.139 -9999.0 0.0 -0.492 20.0 20.0 HHAT 0.008 0.101 -9999.0 0.0 -0.493 10.0 10.0 PI3K 0.03 0.02 -9999.0 0.0 -9999.0 0.0 0.0 EntrezGene:84976 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 GAS1 0.004 0.11 -9999.0 0.0 -0.493 12.0 12.0 somite specification -0.003 0.099 -9999.0 0.0 -0.389 7.0 7.0 SHH Np/Cholesterol/PTCH1 -0.017 0.111 -9999.0 0.0 -0.282 36.0 36.0 SHH Np/Cholesterol/PTCH2 -0.018 0.099 -9999.0 0.0 -0.288 29.0 29.0 SHH Np/Cholesterol/Megalin -0.081 0.142 -9999.0 0.0 -0.291 77.0 77.0 SHH -0.032 0.102 -9999.0 0.0 -0.375 20.0 20.0 catabolic process 0.003 0.098 -9999.0 0.0 -0.346 18.0 18.0 SMO/Vitamin D3 -0.014 0.12 -9999.0 0.0 -0.396 10.0 10.0 SHH Np/Cholesterol/Hhip -0.033 0.12 -9999.0 0.0 -0.314 36.0 36.0 LRP2 -0.12 0.22 -9999.0 0.0 -0.493 66.0 66.0 receptor-mediated endocytosis -0.071 0.138 -9999.0 0.0 -0.452 10.0 10.0 SHH Np/Cholesterol/BOC -0.009 0.086 -9999.0 0.0 -0.285 21.0 21.0 SHH Np/Cholesterol/CDO -0.008 0.094 -9999.0 0.0 -0.315 20.0 20.0 mesenchymal cell differentiation 0.033 0.119 0.313 36.0 -9999.0 0.0 36.0 mol:Vitamin D3 -0.013 0.118 -9999.0 0.0 -0.282 36.0 36.0 IHH N/PTCH2 0.016 0.093 -9999.0 0.0 -0.395 11.0 11.0 CDON 0.023 0.047 -9999.0 0.0 -0.493 2.0 2.0 IHH N/PTCH1 0.012 0.102 -9999.0 0.0 -0.348 18.0 18.0 Megalin/LRPAP1 -0.063 0.174 -9999.0 0.0 -0.359 66.0 66.0 PTCH2 0.003 0.101 -9999.0 0.0 -0.493 10.0 10.0 SHH Np/Cholesterol -0.013 0.082 -9999.0 0.0 -0.289 20.0 20.0 PTCH1 0.003 0.099 -9999.0 0.0 -0.347 18.0 18.0 HHIP -0.02 0.139 -9999.0 0.0 -0.493 20.0 20.0