Stabilization and expansion of the E-cadherin adherens junction Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations adherens junction organization 0.016 0.041 -9999.0 0.0 -0.234 4.0 4.0 epithelial cell differentiation 0.049 0.046 -9999.0 0.0 -0.263 4.0 4.0 CYFIP2 0.028 0.005 -9999.0 0.0 -9999.0 0.0 0.0 ENAH -0.01 0.051 0.27 1.0 -9999.0 0.0 1.0 EGFR 0.014 0.085 -9999.0 0.0 -0.493 7.0 7.0 EPHA2 0.027 0.033 -9999.0 0.0 -0.493 1.0 1.0 MYO6 -0.017 0.046 0.176 1.0 -0.314 5.0 6.0 CTNNB1 0.029 0.003 -9999.0 0.0 -9999.0 0.0 0.0 ABI1/Sra1/Nap1 0.055 0.016 -9999.0 0.0 -9999.0 0.0 0.0 AQP5 -0.048 0.158 -9999.0 0.0 -0.469 30.0 30.0 CTNND1 0.029 0.003 -9999.0 0.0 -9999.0 0.0 0.0 mol:PI-4-5-P2 -0.015 0.033 0.175 1.0 -0.251 4.0 5.0 regulation of calcium-dependent cell-cell adhesion -0.035 0.074 0.175 1.0 -0.256 25.0 26.0 EGF -0.011 0.126 -9999.0 0.0 -0.493 16.0 16.0 NCKAP1 0.029 0.004 -9999.0 0.0 -9999.0 0.0 0.0 AQP3 -0.013 0.093 -9999.0 0.0 -0.424 10.0 10.0 cortical microtubule organization 0.049 0.046 -9999.0 0.0 -0.263 4.0 4.0 GO:0000145 -0.015 0.031 -9999.0 0.0 -0.24 4.0 4.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin 0.054 0.048 -9999.0 0.0 -0.265 4.0 4.0 MLLT4 0.025 0.033 -9999.0 0.0 -0.493 1.0 1.0 ARF6/GDP -0.024 0.029 -9999.0 0.0 -9999.0 0.0 0.0 ARF6 0.029 0.004 -9999.0 0.0 -9999.0 0.0 0.0 Ephrin A1/EPHA2/NCK1/GIT1 0.062 0.035 -9999.0 0.0 -0.282 1.0 1.0 mol:Ca2+ -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 VASP -0.001 0.03 -9999.0 0.0 -0.238 3.0 3.0 PVRL2 0.025 0.033 -9999.0 0.0 -0.493 1.0 1.0 ZYX -0.015 0.034 0.176 1.0 -0.255 4.0 5.0 ARF6/GTP 0.067 0.038 -9999.0 0.0 -0.265 1.0 1.0 CDH1 0.018 0.065 -9999.0 0.0 -0.493 4.0 4.0 EGFR/EGFR/EGF/EGF 0.015 0.094 -9999.0 0.0 -0.254 26.0 26.0 RhoA/GDP 0.051 0.045 -9999.0 0.0 -0.253 4.0 4.0 actin cytoskeleton organization -0.019 0.048 0.163 1.0 -0.308 6.0 7.0 IGF-1R heterotetramer 0.007 0.101 -9999.0 0.0 -0.492 10.0 10.0 GIT1 0.028 0.007 -9999.0 0.0 -9999.0 0.0 0.0 IGF1R 0.007 0.101 -9999.0 0.0 -0.493 10.0 10.0 IGF1 0.011 0.091 -9999.0 0.0 -0.493 8.0 8.0 DIAPH1 0.044 0.099 -9999.0 0.0 -0.537 3.0 3.0 Wnt receptor signaling pathway -0.049 0.046 0.263 4.0 -9999.0 0.0 4.0 RHOA 0.029 0.002 -9999.0 0.0 -9999.0 0.0 0.0 RhoA/GTP -0.024 0.029 -9999.0 0.0 -0.238 4.0 4.0 CTNNA1 0.029 0.004 -9999.0 0.0 -9999.0 0.0 0.0 VCL -0.02 0.049 -9999.0 0.0 -0.315 6.0 6.0 EFNA1 0.028 0.007 -9999.0 0.0 -9999.0 0.0 0.0 LPP -0.014 0.03 -9999.0 0.0 -0.247 2.0 2.0 Ephrin A1/EPHA2 0.041 0.045 -9999.0 0.0 -0.251 4.0 4.0 SEC6/SEC8 -0.022 0.037 -9999.0 0.0 -0.252 6.0 6.0 MGAT3 -0.035 0.075 0.176 1.0 -0.26 25.0 26.0 HGF/MET 0.007 0.107 -9999.0 0.0 -0.263 33.0 33.0 HGF 0.003 0.11 -9999.0 0.0 -0.493 12.0 12.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin/EPLIN 0.016 0.041 -9999.0 0.0 -0.235 4.0 4.0 actin cable formation 0.032 0.073 0.278 7.0 -9999.0 0.0 7.0 KIAA1543 -0.018 0.039 0.163 1.0 -0.254 6.0 7.0 KIFC3 -0.016 0.033 0.176 1.0 -0.255 4.0 5.0 NCK1 0.028 0.006 -9999.0 0.0 -9999.0 0.0 0.0 EXOC3 0.026 0.009 -9999.0 0.0 -9999.0 0.0 0.0 ACTN1 -0.016 0.034 -9999.0 0.0 -0.251 4.0 4.0 NCK1/GIT1 0.039 0.013 -9999.0 0.0 -9999.0 0.0 0.0 mol:GDP 0.049 0.046 -9999.0 0.0 -0.263 4.0 4.0 EXOC4 0.028 0.006 -9999.0 0.0 -9999.0 0.0 0.0 STX4 -0.016 0.034 0.176 1.0 -0.255 4.0 5.0 PIP5K1C -0.015 0.034 -9999.0 0.0 -0.255 4.0 4.0 LIMA1 0.029 0.003 -9999.0 0.0 -9999.0 0.0 0.0 ABI1 0.029 0.004 -9999.0 0.0 -9999.0 0.0 0.0 ROCK1 -0.008 0.061 0.292 2.0 -9999.0 0.0 2.0 adherens junction assembly -0.036 0.129 -9999.0 0.0 -0.689 8.0 8.0 IGF-1R heterotetramer/IGF1 0.02 0.09 -9999.0 0.0 -0.266 21.0 21.0 nectin-2(dimer)/I-afadin/I-afadin/nectin-2(dimer/I-afadin/I-afadin 0.033 0.039 -9999.0 0.0 -0.359 2.0 2.0 MET -0.013 0.139 -9999.0 0.0 -0.493 20.0 20.0 PLEKHA7 -0.018 0.041 0.176 1.0 -0.266 6.0 7.0 mol:GTP 0.059 0.034 -9999.0 0.0 -0.28 1.0 1.0 establishment of epithelial cell apical/basal polarity 0.01 0.088 0.32 5.0 -0.292 1.0 6.0 cortical actin cytoskeleton stabilization 0.016 0.041 -9999.0 0.0 -0.234 4.0 4.0 regulation of cell-cell adhesion -0.019 0.048 0.163 1.0 -0.308 6.0 7.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin/EPLIN/cortical actin cytoskeleton 0.016 0.041 -9999.0 0.0 -0.235 4.0 4.0