Signaling events mediated by the Hedgehog family Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations TGFB2 0.044 0.201 0.457 90.0 -0.502 17.0 107.0 IHH 0.007 0.055 0.194 1.0 -0.144 8.0 9.0 SHH Np/Cholesterol/GAS1 -0.03 0.056 0.129 1.0 -0.162 86.0 87.0 LRPAP1 -0.006 0.025 0.242 3.0 -0.308 2.0 5.0 dorsoventral neural tube patterning 0.03 0.056 0.161 86.0 -0.127 1.0 87.0 SMO/beta Arrestin2 0.016 0.111 -9999.0 0.0 -0.444 8.0 8.0 SMO 0.02 0.119 -9999.0 0.0 -0.464 8.0 8.0 AKT1 -0.022 0.142 -9999.0 0.0 -0.521 7.0 7.0 ARRB2 -0.006 0.0 -9999.0 0.0 -9999.0 0.0 0.0 BOC -0.036 0.091 -9999.0 0.0 -0.308 57.0 57.0 ADRBK1 -0.006 0.0 -9999.0 0.0 -9999.0 0.0 0.0 heart looping 0.02 0.118 -9999.0 0.0 -0.457 8.0 8.0 STIL 0.123 0.115 0.316 92.0 -9999.0 0.0 92.0 DHH N/PTCH2 -0.007 0.0 -9999.0 0.0 -9999.0 0.0 0.0 DHH N/PTCH1 -0.02 0.056 -9999.0 0.0 -0.356 8.0 8.0 PIK3CA 0.047 0.102 0.242 122.0 -9999.0 0.0 122.0 DHH -0.006 0.0 -9999.0 0.0 -9999.0 0.0 0.0 PTHLH 0.039 0.186 0.412 90.0 -0.458 25.0 115.0 determination of left/right symmetry 0.02 0.118 -9999.0 0.0 -0.457 8.0 8.0 PIK3R1 -0.075 0.127 -9999.0 0.0 -0.308 131.0 131.0 skeletal system development 0.04 0.185 0.411 90.0 -0.455 25.0 115.0 IHH N/Hhip 0.005 0.039 0.183 5.0 -9999.0 0.0 5.0 DHH N/Hhip -0.006 0.015 0.17 4.0 -9999.0 0.0 4.0 mol:Cholesterol -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 heart development 0.02 0.118 -9999.0 0.0 -0.457 8.0 8.0 pancreas development -0.004 0.021 0.241 4.0 -9999.0 0.0 4.0 HHAT -0.01 0.033 -9999.0 0.0 -0.308 7.0 7.0 PI3K -0.015 0.115 0.17 98.0 -0.212 107.0 205.0 EntrezGene:84976 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 GAS1 -0.049 0.106 -9999.0 0.0 -0.308 81.0 81.0 somite specification 0.02 0.118 -9999.0 0.0 -0.457 8.0 8.0 SHH Np/Cholesterol/PTCH1 0.014 0.102 0.219 89.0 -0.318 8.0 97.0 SHH Np/Cholesterol/PTCH2 -0.009 0.018 0.129 1.0 -0.158 7.0 8.0 SHH Np/Cholesterol/Megalin 0.03 0.07 0.151 139.0 -0.158 5.0 144.0 SHH -0.009 0.024 0.198 1.0 -0.212 7.0 8.0 catabolic process 0.026 0.134 0.3 90.0 -0.397 8.0 98.0 SMO/Vitamin D3 0.014 0.111 -9999.0 0.0 -0.406 8.0 8.0 SHH Np/Cholesterol/Hhip -0.008 0.022 0.146 5.0 -0.158 7.0 12.0 LRP2 0.056 0.107 0.242 141.0 -9999.0 0.0 141.0 receptor-mediated endocytosis 0.034 0.113 0.305 17.0 -0.426 8.0 25.0 SHH Np/Cholesterol/BOC -0.024 0.049 0.129 1.0 -0.161 63.0 64.0 SHH Np/Cholesterol/CDO -0.007 0.026 0.147 8.0 -0.158 9.0 17.0 mesenchymal cell differentiation 0.008 0.022 0.158 7.0 -0.144 5.0 12.0 mol:Vitamin D3 0.016 0.107 0.234 89.0 -0.319 8.0 97.0 IHH N/PTCH2 0.003 0.035 0.122 1.0 -9999.0 0.0 1.0 CDON -0.004 0.033 0.242 7.0 -0.308 2.0 9.0 IHH N/PTCH1 0.024 0.129 0.284 90.0 -0.399 8.0 98.0 Megalin/LRPAP1 0.037 0.078 0.17 144.0 -0.212 2.0 146.0 PTCH2 -0.006 0.0 -9999.0 0.0 -9999.0 0.0 0.0 SHH Np/Cholesterol -0.007 0.017 -9999.0 0.0 -0.156 7.0 7.0 PTCH1 0.027 0.135 0.301 90.0 -0.398 8.0 98.0 HHIP -0.004 0.021 0.242 4.0 -9999.0 0.0 4.0