E-cadherin signaling in the nascent adherens junction Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations CTTN -0.045 0.101 -9999.0 0.0 -0.323 62.0 62.0 KLHL20 -0.057 0.078 0.468 1.0 -0.275 17.0 18.0 CYFIP2 0.029 0.006 -9999.0 0.0 0.0 24.0 24.0 Rac1/GDP -0.044 0.079 0.231 6.0 -0.251 18.0 24.0 ENAH -0.046 0.102 -9999.0 0.0 -0.321 64.0 64.0 AP1M1 0.026 0.01 -9999.0 0.0 0.0 65.0 65.0 RAP1B 0.029 0.006 -9999.0 0.0 0.0 23.0 23.0 RAP1A 0.029 0.004 -9999.0 0.0 0.0 8.0 8.0 CTNNB1 0.029 0.004 -9999.0 0.0 0.0 8.0 8.0 CDC42/GTP -0.057 0.051 0.116 25.0 -0.234 2.0 27.0 ABI1/Sra1/Nap1 -0.052 0.045 -9999.0 0.0 -0.169 34.0 34.0 E-cadherin/beta catenin/alpha catenin/beta7/alphaE Integrin 0.057 0.047 -9999.0 0.0 -0.142 8.0 8.0 RAPGEF1 -0.045 0.098 0.238 4.0 -0.307 53.0 57.0 CTNND1 0.029 0.003 -9999.0 0.0 0.0 5.0 5.0 regulation of calcium-dependent cell-cell adhesion -0.022 0.113 -9999.0 0.0 -0.322 66.0 66.0 CRK -0.045 0.101 -9999.0 0.0 -0.318 58.0 58.0 E-cadherin/gamma catenin/alpha catenin 0.044 0.043 -9999.0 0.0 -0.157 18.0 18.0 alphaE/beta7 Integrin 0.041 0.014 -9999.0 0.0 -0.164 1.0 1.0 IQGAP1 0.029 0.006 -9999.0 0.0 0.0 24.0 24.0 NCKAP1 0.029 0.005 -9999.0 0.0 0.0 17.0 17.0 Rap1/GTP/I-afadin 0.04 0.043 -9999.0 0.0 -0.131 21.0 21.0 DLG1 -0.031 0.102 0.192 1.0 -0.323 52.0 53.0 ChemicalAbstracts:7440-70-2 -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 mol:PI-3-4-5-P3 -0.043 0.042 -9999.0 0.0 -0.147 17.0 17.0 MLLT4 0.026 0.01 -9999.0 0.0 0.0 72.0 72.0 ARF6/GTP/NME1/Tiam1 0.048 0.024 -9999.0 0.0 -0.131 1.0 1.0 PI3K -0.053 0.054 -9999.0 0.0 -0.189 15.0 15.0 ARF6 0.029 0.004 -9999.0 0.0 0.0 11.0 11.0 mol:Ca2+ -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/gamma catenin 0.031 0.041 -9999.0 0.0 -0.177 18.0 18.0 TIAM1 0.028 0.006 -9999.0 0.0 -0.001 24.0 24.0 E-cadherin(dimer)/Ca2+ 0.053 0.042 -9999.0 0.0 -0.132 7.0 7.0 AKT1 -0.012 0.069 0.134 54.0 -0.145 1.0 55.0 PIK3R1 0.021 0.013 -9999.0 0.0 0.0 159.0 159.0 CDH1 0.026 0.01 -9999.0 0.0 -0.0 70.0 70.0 RhoA/GDP -0.043 0.08 0.232 6.0 -0.249 19.0 25.0 actin cytoskeleton organization -0.043 0.059 0.405 1.0 -0.219 8.0 9.0 CDC42/GDP -0.042 0.08 0.232 6.0 -0.249 19.0 25.0 E-cadherin/Ca2+/gamma catenin/alpha catenin/p120 catenin -0.013 0.057 -9999.0 0.0 -0.189 33.0 33.0 ITGB7 0.029 0.004 -9999.0 0.0 0.0 8.0 8.0 RAC1 0.028 0.007 -9999.0 0.0 -0.001 27.0 27.0 E-cadherin/beta catenin/alpha catenin/p120 catenin 0.058 0.045 -9999.0 0.0 -0.142 7.0 7.0 E-cadherin/Ca2+/beta catenin/alpha catenin 0.04 0.032 -9999.0 0.0 -0.122 7.0 7.0 mol:GDP -0.042 0.085 0.233 6.0 -0.274 21.0 27.0 CDC42/GTP/IQGAP1 0.037 0.014 -9999.0 0.0 -0.134 2.0 2.0 JUP 0.028 0.008 -9999.0 0.0 0.0 40.0 40.0 p120 catenin/RhoA/GDP -0.045 0.083 0.239 6.0 -0.258 16.0 22.0 RAC1/GTP/IQGAP1 0.036 0.015 -9999.0 0.0 -0.134 2.0 2.0 PIP5K1C/AP1M1 0.037 0.017 -9999.0 0.0 -9999.0 0.0 0.0 RHOA 0.029 0.003 -9999.0 0.0 0.0 7.0 7.0 CDC42 0.029 0.005 -9999.0 0.0 0.0 13.0 13.0 CTNNA1 0.029 0.004 -9999.0 0.0 0.0 13.0 13.0 positive regulation of S phase of mitotic cell cycle -0.044 0.057 0.092 3.0 -0.13 144.0 147.0 NME1 0.028 0.008 -9999.0 0.0 0.0 42.0 42.0 clathrin coat assembly 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 TJP1 -0.047 0.104 -9999.0 0.0 -0.322 66.0 66.0 regulation of cell-cell adhesion -0.053 0.041 0.083 24.0 -0.207 2.0 26.0 WASF2 -0.03 0.035 0.096 5.0 -0.105 34.0 39.0 Rap1/GTP -0.053 0.058 0.153 25.0 -0.252 2.0 27.0 E-cadherin/gamma catenin/alpha catenin/beta7/alphaE Integrin 0.058 0.063 -9999.0 0.0 -0.152 18.0 18.0 CCND1 -0.054 0.07 0.106 3.0 -0.158 146.0 149.0 VAV2 -0.038 0.165 -9999.0 0.0 -0.66 24.0 24.0 RAP1/GDP -0.044 0.067 0.243 4.0 -0.245 4.0 8.0 adherens junction assembly -0.045 0.101 -9999.0 0.0 -0.313 66.0 66.0 homophilic cell adhesion -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ABI1 0.029 0.005 -9999.0 0.0 0.0 14.0 14.0 PIP5K1C 0.027 0.008 -9999.0 0.0 0.0 44.0 44.0 regulation of heterotypic cell-cell adhesion -0.06 0.03 0.172 4.0 -0.229 2.0 6.0 E-cadherin/beta catenin -0.009 0.048 -9999.0 0.0 -0.179 37.0 37.0 mol:GTP -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 SRC -0.044 0.1 -9999.0 0.0 -0.325 60.0 60.0 PIK3CA 0.021 0.014 -9999.0 0.0 0.0 174.0 174.0 Rac1/GTP -0.088 0.112 0.553 1.0 -0.402 33.0 34.0 E-cadherin/beta catenin/alpha catenin 0.049 0.03 -9999.0 0.0 -0.146 7.0 7.0 ITGAE 0.028 0.007 -9999.0 0.0 0.0 30.0 30.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin -0.022 0.115 -9999.0 0.0 -0.328 66.0 66.0