Signaling events mediated by the Hedgehog family Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations TGFB2 -0.092 0.178 -9999.0 0.0 -0.63 13.0 13.0 IHH -0.218 0.199 -9999.0 0.0 -0.365 113.0 113.0 SHH Np/Cholesterol/GAS1 -0.025 0.113 -9999.0 0.0 -0.218 42.0 42.0 LRPAP1 0.037 0.007 -9999.0 0.0 -9999.0 0.0 0.0 dorsoventral neural tube patterning 0.025 0.112 0.217 42.0 -9999.0 0.0 42.0 SMO/beta Arrestin2 -0.06 0.161 -9999.0 0.0 -0.531 13.0 13.0 SMO -0.071 0.161 -9999.0 0.0 -0.547 13.0 13.0 AKT1 -0.014 0.149 -9999.0 0.0 -0.714 6.0 6.0 ARRB2 0.031 0.033 -9999.0 0.0 -0.372 1.0 1.0 BOC 0.03 0.053 -9999.0 0.0 -0.372 3.0 3.0 ADRBK1 0.037 0.007 -9999.0 0.0 -9999.0 0.0 0.0 heart looping -0.07 0.158 -9999.0 0.0 -0.537 13.0 13.0 STIL -0.089 0.134 -9999.0 0.0 -0.424 11.0 11.0 DHH N/PTCH2 0.003 0.121 -9999.0 0.0 -0.286 25.0 25.0 DHH N/PTCH1 -0.078 0.131 -9999.0 0.0 -0.404 14.0 14.0 PIK3CA 0.034 0.032 -9999.0 0.0 -0.372 1.0 1.0 DHH 0.019 0.08 -9999.0 0.0 -0.372 7.0 7.0 PTHLH -0.084 0.198 -9999.0 0.0 -0.786 10.0 10.0 determination of left/right symmetry -0.07 0.158 -9999.0 0.0 -0.537 13.0 13.0 PIK3R1 0.036 0.009 -9999.0 0.0 -9999.0 0.0 0.0 skeletal system development -0.084 0.195 -9999.0 0.0 -0.776 10.0 10.0 IHH N/Hhip -0.133 0.147 -9999.0 0.0 -0.23 113.0 113.0 DHH N/Hhip 0.018 0.102 -9999.0 0.0 -0.27 19.0 19.0 mol:Cholesterol 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 heart development -0.07 0.158 -9999.0 0.0 -0.537 13.0 13.0 pancreas development 0.004 0.11 -9999.0 0.0 -0.37 14.0 14.0 HHAT 0.036 0.01 -9999.0 0.0 -9999.0 0.0 0.0 PI3K 0.051 0.025 -9999.0 0.0 -0.223 1.0 1.0 EntrezGene:84976 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 GAS1 -0.007 0.126 -9999.0 0.0 -0.371 19.0 19.0 somite specification -0.07 0.158 -9999.0 0.0 -0.537 13.0 13.0 SHH Np/Cholesterol/PTCH1 -0.095 0.138 -9999.0 0.0 -0.329 32.0 32.0 SHH Np/Cholesterol/PTCH2 -0.032 0.112 -9999.0 0.0 -0.208 48.0 48.0 SHH Np/Cholesterol/Megalin -0.034 0.111 -9999.0 0.0 -0.208 48.0 48.0 SHH -0.035 0.109 -9999.0 0.0 -0.257 34.0 34.0 catabolic process -0.092 0.132 -9999.0 0.0 -0.432 14.0 14.0 SMO/Vitamin D3 -0.086 0.155 -9999.0 0.0 -0.48 14.0 14.0 SHH Np/Cholesterol/Hhip -0.024 0.108 -9999.0 0.0 -0.211 42.0 42.0 LRP2 -0.018 0.134 -9999.0 0.0 -0.364 23.0 23.0 receptor-mediated endocytosis -0.094 0.157 -9999.0 0.0 -0.487 15.0 15.0 SHH Np/Cholesterol/BOC -0.01 0.091 -9999.0 0.0 -0.193 34.0 34.0 SHH Np/Cholesterol/CDO -0.008 0.089 -9999.0 0.0 -0.192 33.0 33.0 mesenchymal cell differentiation 0.024 0.107 0.21 42.0 -9999.0 0.0 42.0 mol:Vitamin D3 -0.091 0.145 0.25 1.0 -0.33 32.0 33.0 IHH N/PTCH2 -0.144 0.154 -9999.0 0.0 -0.239 116.0 116.0 CDON 0.035 0.031 -9999.0 0.0 -0.372 1.0 1.0 IHH N/PTCH1 -0.09 0.137 -9999.0 0.0 -0.436 14.0 14.0 Megalin/LRPAP1 0.016 0.098 -9999.0 0.0 -0.256 20.0 20.0 PTCH2 -0.012 0.132 -9999.0 0.0 -0.372 21.0 21.0 SHH Np/Cholesterol -0.02 0.084 -9999.0 0.0 -0.192 34.0 34.0 PTCH1 -0.093 0.132 -9999.0 0.0 -0.433 14.0 14.0 HHIP 0.004 0.11 -9999.0 0.0 -0.37 14.0 14.0