Signaling events mediated by the Hedgehog family Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations TGFB2 0.059 0.121 0.436 15.0 -9999.0 0.0 15.0 IHH 0.049 0.047 -9999.0 0.0 -9999.0 0.0 0.0 SHH Np/Cholesterol/GAS1 -0.041 0.105 -9999.0 0.0 -0.22 40.0 40.0 LRPAP1 0.027 0.005 -9999.0 0.0 -9999.0 0.0 0.0 dorsoventral neural tube patterning 0.041 0.104 0.219 40.0 -9999.0 0.0 40.0 SMO/beta Arrestin2 0.029 0.119 0.411 1.0 -0.519 1.0 2.0 SMO 0.015 0.113 0.297 12.0 -0.539 1.0 13.0 AKT1 0.005 0.113 -9999.0 0.0 -0.403 5.0 5.0 ARRB2 0.026 0.008 -9999.0 0.0 -9999.0 0.0 0.0 BOC 0.025 0.009 -9999.0 0.0 -9999.0 0.0 0.0 ADRBK1 0.027 0.005 -9999.0 0.0 -9999.0 0.0 0.0 heart looping 0.015 0.112 0.296 12.0 -0.531 1.0 13.0 STIL -0.008 0.118 0.243 13.0 -9999.0 0.0 13.0 DHH N/PTCH2 0.033 0.029 -9999.0 0.0 -0.274 1.0 1.0 DHH N/PTCH1 0.063 0.08 0.31 15.0 -9999.0 0.0 15.0 PIK3CA 0.025 0.009 -9999.0 0.0 -9999.0 0.0 0.0 DHH 0.028 0.004 -9999.0 0.0 -9999.0 0.0 0.0 PTHLH 0.065 0.147 0.524 15.0 -9999.0 0.0 15.0 determination of left/right symmetry 0.015 0.112 0.296 12.0 -0.531 1.0 13.0 PIK3R1 0.027 0.005 -9999.0 0.0 -9999.0 0.0 0.0 skeletal system development 0.064 0.147 0.523 15.0 -9999.0 0.0 15.0 IHH N/Hhip -0.17 0.167 -9999.0 0.0 -0.296 102.0 102.0 DHH N/Hhip -0.155 0.151 -9999.0 0.0 -0.274 100.0 100.0 mol:Cholesterol 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 heart development 0.015 0.112 0.296 12.0 -0.531 1.0 13.0 pancreas development -0.232 0.197 -9999.0 0.0 -0.383 102.0 102.0 HHAT 0.026 0.008 -9999.0 0.0 -9999.0 0.0 0.0 PI3K 0.036 0.014 -9999.0 0.0 -9999.0 0.0 0.0 EntrezGene:84976 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 GAS1 -0.0 0.104 -9999.0 0.0 -0.384 11.0 11.0 somite specification 0.015 0.112 0.296 12.0 -0.531 1.0 13.0 SHH Np/Cholesterol/PTCH1 -0.004 0.111 0.27 12.0 -9999.0 0.0 12.0 SHH Np/Cholesterol/PTCH2 -0.032 0.092 -9999.0 0.0 -0.21 34.0 34.0 SHH Np/Cholesterol/Megalin -0.056 0.079 -9999.0 0.0 -0.212 33.0 33.0 SHH -0.068 0.105 -9999.0 0.0 -0.274 33.0 33.0 catabolic process 0.056 0.102 0.372 15.0 -9999.0 0.0 15.0 SMO/Vitamin D3 0.0 0.133 0.315 13.0 -0.314 1.0 14.0 SHH Np/Cholesterol/Hhip -0.152 0.136 -9999.0 0.0 -0.248 101.0 101.0 LRP2 0.018 0.001 -9999.0 0.0 -9999.0 0.0 0.0 receptor-mediated endocytosis -0.015 0.119 0.254 12.0 -0.352 1.0 13.0 SHH Np/Cholesterol/BOC -0.031 0.092 -9999.0 0.0 -0.211 33.0 33.0 SHH Np/Cholesterol/CDO -0.029 0.092 -9999.0 0.0 -0.211 33.0 33.0 mesenchymal cell differentiation 0.152 0.135 0.246 101.0 -9999.0 0.0 101.0 mol:Vitamin D3 0.02 0.137 0.316 14.0 -9999.0 0.0 14.0 IHH N/PTCH2 0.045 0.043 -9999.0 0.0 -0.303 1.0 1.0 CDON 0.027 0.006 -9999.0 0.0 -9999.0 0.0 0.0 IHH N/PTCH1 0.069 0.104 0.395 15.0 -9999.0 0.0 15.0 Megalin/LRPAP1 0.033 0.007 -9999.0 0.0 -9999.0 0.0 0.0 PTCH2 0.022 0.033 -9999.0 0.0 -0.384 1.0 1.0 SHH Np/Cholesterol -0.033 0.087 -9999.0 0.0 -0.206 33.0 33.0 PTCH1 0.056 0.102 0.373 15.0 -9999.0 0.0 15.0 HHIP -0.233 0.197 -9999.0 0.0 -0.384 102.0 102.0