Pathway Name	Avg Num Perturbations	Total Perturbations	Num Entities	Min Mean Truth	Max Mean Truth	Min Mean Within	Max Mean Within	Min Mean Any	Max Mean Within
PDGFR-alpha signaling pathway	51.0	2271.0	44.0	-0.21	0.037	1000.0	-1000.0	-0.014	-1000.0
Noncanonical Wnt signaling pathway	50.0	1313.0	26.0	-0.296	0.027	1000.0	-1000.0	-0.025	-1000.0
Wnt signaling	43.0	303.0	7.0	-0.296	0.026	1000.0	-1000.0	-0.007	-1000.0
Ras signaling in the CD4+ TCR pathway	31.0	540.0	17.0	-0.278	0.043	1000.0	-1000.0	-0.002	-1000.0
Signaling mediated by p38-alpha and p38-beta	28.0	1239.0	44.0	-0.257	0.026	1000.0	-1000.0	-0.017	-1000.0
IL23-mediated signaling events	28.0	1731.0	60.0	-0.588	0.028	1000.0	-1000.0	-0.005	-1000.0
mTOR signaling pathway	25.0	1369.0	53.0	-0.159	0.08	1000.0	-1000.0	-0.027	-1000.0
Thromboxane A2 receptor signaling	24.0	2605.0	105.0	-0.295	0.082	1000.0	-1000.0	-0.03	-1000.0
RXR and RAR heterodimerization with other nuclear receptor	24.0	1256.0	52.0	-0.222	0.028	1000.0	-1000.0	-0.019	-1000.0
Signaling events mediated by the Hedgehog family	22.0	1144.0	52.0	-0.233	0.152	1000.0	-1000.0	-0.018	-1000.0
EGFR-dependent Endothelin signaling events	19.0	406.0	21.0	-0.107	0.039	1000.0	-1000.0	-0.025	-1000.0
IL1-mediated signaling events	18.0	1124.0	62.0	-0.217	0.055	1000.0	-1000.0	-0.043	-1000.0
IL6-mediated signaling events	17.0	1290.0	75.0	-0.315	0.037	1000.0	-1000.0	-0.018	-1000.0
Syndecan-1-mediated signaling events	16.0	546.0	34.0	-0.069	0.027	1000.0	-1000.0	-0.016	-1000.0
Glucocorticoid receptor regulatory network	16.0	1897.0	114.0	-0.531	0.137	1000.0	-1000.0	-0.043	-1000.0
Integrins in angiogenesis	16.0	1390.0	84.0	-0.288	0.067	1000.0	-1000.0	-0.039	-1000.0
Glypican 1 network	15.0	763.0	48.0	-0.255	0.053	1000.0	-1000.0	-0.022	-1000.0
Insulin Pathway	15.0	1141.0	74.0	-0.293	0.091	1000.0	-1000.0	-0.046	-1000.0
amb2 Integrin signaling	14.0	1164.0	82.0	-0.213	0.035	1000.0	-1000.0	-0.008	-1000.0
IL12-mediated signaling events	13.0	1211.0	87.0	-0.164	0.05	1000.0	-1000.0	-0.055	-1000.0
IL4-mediated signaling events	13.0	1194.0	91.0	-0.431	0.493	1000.0	-1000.0	-0.048	-1000.0
Syndecan-3-mediated signaling events	13.0	464.0	35.0	-0.178	0.068	1000.0	-1000.0	-0.02	-1000.0
HIF-1-alpha transcription factor network	12.0	934.0	76.0	-0.123	0.053	1000.0	-1000.0	-0.029	-1000.0
FOXA2 and FOXA3 transcription factor networks	12.0	592.0	46.0	-0.891	0.234	1000.0	-1000.0	-0.009	-1000.0
IGF1 pathway	12.0	684.0	57.0	-0.083	0.067	1000.0	-1000.0	-0.034	-1000.0
Plasma membrane estrogen receptor signaling	12.0	1066.0	86.0	-0.1	0.064	1000.0	-1000.0	-0.041	-1000.0
TCGA08_rtk_signaling	11.0	308.0	26.0	-0.206	0.028	1000.0	-1000.0	-0.014	-1000.0
Cellular roles of Anthrax toxin	10.0	412.0	39.0	-0.137	0.027	1000.0	-1000.0	-0.014	-1000.0
LPA receptor mediated events	10.0	1023.0	102.0	-0.288	0.113	1000.0	-1000.0	-0.06	-1000.0
Coregulation of Androgen receptor activity	9.0	752.0	76.0	-0.214	0.063	1000.0	-1000.0	-0.019	-1000.0
Arf6 signaling events	9.0	618.0	62.0	-0.148	0.068	1000.0	-1000.0	-0.037	-1000.0
Ephrin A  reverse signaling	8.0	59.0	7.0	-0.0	0.046	1000.0	-1000.0	-0.014	-1000.0
Syndecan-2-mediated signaling events	8.0	604.0	69.0	-0.178	0.045	1000.0	-1000.0	-0.02	-1000.0
BMP receptor signaling	8.0	698.0	81.0	-0.304	0.127	1000.0	-1000.0	-0.026	-1000.0
Retinoic acid receptors-mediated signaling	8.0	499.0	58.0	-0.222	0.056	1000.0	-1000.0	-0.018	-1000.0
Nongenotropic Androgen signaling	8.0	439.0	52.0	-0.052	0.049	1000.0	-1000.0	-0.02	-1000.0
Signaling events mediated by PTP1B	7.0	595.0	76.0	-0.181	0.081	1000.0	-1000.0	-0.028	-1000.0
Nectin adhesion pathway	7.0	448.0	63.0	-0.295	0.067	1000.0	-1000.0	-0.028	-1000.0
Calcineurin-regulated NFAT-dependent transcription in lymphocytes	7.0	511.0	68.0	-0.279	0.064	1000.0	-1000.0	-0.031	-1000.0
Syndecan-4-mediated signaling events	7.0	492.0	67.0	-0.081	0.037	1000.0	-1000.0	-0.027	-1000.0
Nephrin/Neph1 signaling in the kidney podocyte	6.0	233.0	34.0	-0.013	0.046	1000.0	-1000.0	-0.021	-1000.0
Endothelins	6.0	631.0	96.0	-0.072	0.061	1000.0	-1000.0	-0.027	-1000.0
Effects of Botulinum toxin	6.0	179.0	26.0	-0.0	0.084	1000.0	-1000.0	-0.007	-1000.0
Angiopoietin receptor Tie2-mediated signaling	6.0	596.0	88.0	-0.293	0.104	1000.0	-1000.0	-0.052	-1000.0
Signaling events activated by Hepatocyte Growth Factor Receptor (c-Met)	5.0	438.0	85.0	-0.093	0.051	1000.0	-1000.0	-0.026	-1000.0
Fc-epsilon receptor I signaling in mast cells	5.0	508.0	97.0	-0.051	0.049	1000.0	-1000.0	-0.043	-1000.0
Ceramide signaling pathway	5.0	430.0	76.0	-0.065	0.05	1000.0	-1000.0	-0.021	-1000.0
Reelin signaling pathway	5.0	291.0	56.0	-0.005	0.382	1000.0	-1000.0	-0.018	-1000.0
TCGA08_p53	5.0	37.0	7.0	-0.009	0.025	1000.0	-1000.0	-0.006	-1000.0
FoxO family signaling	5.0	348.0	64.0	-0.293	0.038	1000.0	-1000.0	-0.013	-1000.0
FAS signaling pathway (CD95)	5.0	263.0	47.0	-0.325	0.043	1000.0	-1000.0	-0.016	-1000.0
IL2 signaling events mediated by PI3K	5.0	298.0	58.0	-0.114	0.035	1000.0	-1000.0	-0.025	-1000.0
Canonical Wnt signaling pathway	5.0	278.0	51.0	-0.162	0.064	1000.0	-1000.0	-0.025	-1000.0
BCR signaling pathway	5.0	560.0	99.0	-0.083	0.072	1000.0	-1000.0	-0.046	-1000.0
PDGFR-beta signaling pathway	5.0	497.0	97.0	-0.075	0.062	1000.0	-1000.0	-0.046	-1000.0
FOXM1 transcription factor network	5.0	259.0	51.0	-0.036	0.068	1000.0	-1000.0	0.012	-1000.0
Regulation of Androgen receptor activity	5.0	353.0	70.0	-0.263	0.033	1000.0	-1000.0	-0.022	-1000.0
Regulation of nuclear SMAD2/3 signaling	4.0	560.0	136.0	-0.222	0.139	1000.0	-1000.0	-0.029	-1000.0
ErbB4 signaling events	4.0	342.0	69.0	-0.139	0.093	1000.0	-1000.0	-0.015	-1000.0
Circadian rhythm pathway	4.0	99.0	22.0	-0.08	0.027	1000.0	-1000.0	-0.021	-1000.0
Presenilin action in Notch and Wnt signaling	4.0	258.0	61.0	-0.176	0.067	1000.0	-1000.0	-0.03	-1000.0
Paxillin-independent events mediated by a4b1 and a4b7	4.0	178.0	37.0	-0.09	0.074	1000.0	-1000.0	-0.018	-1000.0
TRAIL signaling pathway	4.0	213.0	48.0	-0.035	0.057	1000.0	-1000.0	-0.02	-1000.0
Signaling events regulated by Ret tyrosine kinase	4.0	329.0	82.0	-0.181	0.101	1000.0	-1000.0	-0.041	-1000.0
ceramide signaling pathway	4.0	199.0	49.0	-0.0	0.047	1000.0	-1000.0	-0.016	-1000.0
S1P1 pathway	4.0	157.0	36.0	-0.118	0.027	1000.0	-1000.0	-0.024	-1000.0
Regulation of p38-alpha and p38-beta	4.0	240.0	54.0	-0.067	0.059	1000.0	-1000.0	-0.035	-1000.0
E-cadherin signaling in keratinocytes	4.0	184.0	43.0	-0.107	0.047	1000.0	-1000.0	-0.013	-1000.0
Signaling events mediated by Stem cell factor receptor (c-Kit)	4.0	364.0	78.0	-0.029	0.068	1000.0	-1000.0	-0.022	-1000.0
ErbB2/ErbB3 signaling events	3.0	235.0	65.0	-0.02	0.077	1000.0	-1000.0	-0.046	-1000.0
Osteopontin-mediated events	3.0	128.0	38.0	-0.016	0.066	1000.0	-1000.0	-0.014	-1000.0
Arf6 downstream pathway	3.0	146.0	43.0	-0.04	0.051	1000.0	-1000.0	-0.023	-1000.0
PLK1 signaling events	3.0	260.0	85.0	-0.014	0.054	1000.0	-1000.0	-0.027	-1000.0
Insulin-mediated glucose transport	3.0	103.0	32.0	-0.089	0.05	1000.0	-1000.0	-0.02	-1000.0
Class I PI3K signaling events mediated by Akt	3.0	246.0	68.0	-0.048	0.054	1000.0	-1000.0	-0.019	-1000.0
Signaling events mediated by HDAC Class III	3.0	127.0	40.0	-0.089	0.048	1000.0	-1000.0	-0.029	-1000.0
HIF-2-alpha transcription factor network	3.0	163.0	43.0	-0.135	0.055	1000.0	-1000.0	-0.068	-1000.0
Paxillin-dependent events mediated by a4b1	3.0	108.0	36.0	-0.09	0.062	1000.0	-1000.0	-0.028	-1000.0
TCR signaling in naïve CD8+ T cells	3.0	349.0	93.0	-0.082	0.104	1000.0	-1000.0	-0.033	-1000.0
Calcium signaling in the CD4+ TCR pathway	3.0	122.0	31.0	-0.098	0.027	1000.0	-1000.0	-0.026	-1000.0
IL27-mediated signaling events	3.0	182.0	51.0	-0.092	0.027	1000.0	-1000.0	-0.035	-1000.0
Stabilization and expansion of the E-cadherin adherens junction	3.0	263.0	74.0	-0.107	0.059	1000.0	-1000.0	-0.049	-1000.0
S1P3 pathway	3.0	162.0	42.0	-0.04	0.073	1000.0	-1000.0	-0.014	-1000.0
Neurotrophic factor-mediated Trk receptor signaling	3.0	449.0	120.0	-0.033	0.112	1000.0	-1000.0	-0.033	-1000.0
Visual signal transduction: Rods	3.0	186.0	52.0	-0.037	0.06	1000.0	-1000.0	-0.01	-1000.0
Caspase cascade in apoptosis	2.0	202.0	74.0	-0.156	0.067	1000.0	-1000.0	-0.023	-1000.0
Lissencephaly gene (LIS1) in neuronal migration and development	2.0	140.0	54.0	-0.018	0.107	1000.0	-1000.0	-0.037	-1000.0
Hedgehog signaling events mediated by Gli proteins	2.0	172.0	65.0	-0.007	0.066	1000.0	-1000.0	-0.016	-1000.0
p75(NTR)-mediated signaling	2.0	364.0	125.0	-0.039	0.068	1000.0	-1000.0	-0.052	-1000.0
EPO signaling pathway	2.0	159.0	55.0	-0.027	0.065	1000.0	-1000.0	-0.02	-1000.0
Role of Calcineurin-dependent NFAT signaling in lymphocytes	2.0	234.0	83.0	-0.065	0.053	1000.0	-1000.0	-0.016	-1000.0
Signaling mediated by p38-gamma and p38-delta	2.0	43.0	15.0	-0.025	0.098	1000.0	-1000.0	-0.017	-1000.0
EPHB forward signaling	2.0	199.0	85.0	-0.058	0.104	1000.0	-1000.0	-0.048	-1000.0
IL2 signaling events mediated by STAT5	2.0	48.0	22.0	-0.044	0.028	1000.0	-1000.0	-0.021	-1000.0
Class I PI3K signaling events	2.0	204.0	73.0	-0.117	0.054	1000.0	-1000.0	-0.022	-1000.0
Arf6 trafficking events	2.0	161.0	71.0	-0.049	0.051	1000.0	-1000.0	-0.024	-1000.0
Regulation of Telomerase	2.0	213.0	102.0	-0.107	0.067	1000.0	-1000.0	-0.027	-1000.0
Hypoxic and oxygen homeostasis regulation of HIF-1-alpha	2.0	83.0	33.0	-0.062	0.07	1000.0	-1000.0	-0.018	-1000.0
S1P4 pathway	2.0	61.0	25.0	-0.0	0.073	1000.0	-1000.0	-0.015	-1000.0
p38 MAPK signaling pathway	2.0	89.0	44.0	-0.031	0.046	1000.0	-1000.0	-0.011	-1000.0
Aurora B signaling	2.0	155.0	67.0	-0.123	0.072	1000.0	-1000.0	-0.025	-1000.0
LPA4-mediated signaling events	1.0	23.0	12.0	-0.013	0.016	1000.0	-1000.0	-0.013	-1000.0
Regulation of cytoplasmic and nuclear SMAD2/3 signaling	1.0	24.0	23.0	-0.014	0.053	1000.0	-1000.0	-0.02	-1000.0
Sphingosine 1-phosphate (S1P) pathway	1.0	52.0	28.0	-0.041	0.067	1000.0	-1000.0	-0.017	-1000.0
Visual signal transduction: Cones	1.0	50.0	38.0	-0.016	0.059	1000.0	-1000.0	-0.017	-1000.0
JNK signaling in the CD4+ TCR pathway	1.0	31.0	17.0	0.004	0.061	1000.0	-1000.0	-0.013	-1000.0
IFN-gamma pathway	1.0	113.0	68.0	-0.059	0.103	1000.0	-1000.0	-0.045	-1000.0
Ephrin B reverse signaling	1.0	53.0	48.0	-0.051	0.065	1000.0	-1000.0	-0.033	-1000.0
Signaling events mediated by HDAC Class I	1.0	124.0	104.0	-0.048	0.064	1000.0	-1000.0	-0.028	-1000.0
HIV-1 Nef: Negative effector of Fas and TNF-alpha	1.0	67.0	45.0	-0.011	0.058	1000.0	-1000.0	-0.03	-1000.0
E-cadherin signaling in the nascent adherens junction	1.0	104.0	76.0	-0.028	0.068	1000.0	-1000.0	-0.042	-1000.0
Rapid glucocorticoid signaling	1.0	38.0	20.0	-0.0	0.032	1000.0	-1000.0	-0.01	-1000.0
Signaling events mediated by PRL	1.0	61.0	34.0	-0.024	0.038	1000.0	-1000.0	-0.025	-1000.0
Canonical NF-kappaB pathway	0.0	22.0	39.0	-0.015	0.057	1000.0	-1000.0	-0.023	-1000.0
Signaling events mediated by HDAC Class II	0.0	16.0	75.0	-0.03	0.076	1000.0	-1000.0	-0.026	-1000.0
BARD1 signaling events	0.0	10.0	57.0	-0.059	0.071	1000.0	-1000.0	-0.039	-1000.0
PLK2 and PLK4 events	0.0	0.0	3.0	-0.017	0.028	1000.0	-1000.0	-0.017	-1000.0
a4b1 and a4b7 Integrin signaling	0.0	2.0	5.0	0.025	0.039	1000.0	-1000.0	0.016	-1000.0
Aurora A signaling	0.0	13.0	60.0	-0.016	0.051	1000.0	-1000.0	-0.018	-1000.0
Aurora C signaling	0.0	3.0	7.0	-0.0	0.046	1000.0	-1000.0	-0.015	-1000.0
S1P5 pathway	0.0	5.0	17.0	-0.072	0.074	1000.0	-1000.0	-0.004	-1000.0
Atypical NF-kappaB pathway	0.0	15.0	31.0	-0.016	0.036	1000.0	-1000.0	-0.018	-1000.0
Glypican 2 network	0.0	0.0	4.0	0.026	0.035	1000.0	-1000.0	0.014	-1000.0
Signaling events mediated by VEGFR1 and VEGFR2	0.0	85.0	125.0	-0.025	0.069	1000.0	-1000.0	-0.051	-1000.0
Sumoylation by RanBP2 regulates transcriptional repression	0.0	10.0	27.0	-0.02	0.066	1000.0	-1000.0	-0.029	-1000.0
TCGA08_retinoblastoma	0.0	0.0	8.0	-0.006	0.028	1000.0	-1000.0	-0.006	-1000.0
VEGFR1 specific signals	0.0	26.0	56.0	-0.017	0.068	1000.0	-1000.0	-0.028	-1000.0
Class IB PI3K non-lipid kinase events	0.0	0.0	3.0	-0.026	0.026	1000.0	-1000.0	-0.018	-1000.0
E-cadherin signaling events	0.0	0.0	5.0	0.024	0.047	1000.0	-1000.0	0.017	-1000.0
Arf1 pathway	0.0	17.0	54.0	-0.008	0.049	1000.0	-1000.0	-0.012	-1000.0
Alternative NF-kappaB pathway	0.0	0.0	13.0	-0.0	0.071	1000.0	-1000.0	-0.0	-1000.0
Total	905	53137	7203	-15.3799008005	8.73299885541	131000	-131000	-3.12001104674	-131000