Clinical Features CN_CNMF METHLYATION_CNMF RPPA_CNMF RPPA_CHIERARCHICAL MRNASEQ_CNMF MRNASEQ_CHIERARCHICAL MIRSEQ_CNMF MIRSEQ_CHIERARCHICAL MIRSEQ_MATURE_CNMF MIRSEQ_MATURE_CHIERARCHICAL nMutated (%) nWild-Type Fisher's exact test_P Fisher's exact test_Q Fisher's exact test_P Fisher's exact test_Q Fisher's exact test_P Fisher's exact test_Q Fisher's exact test_P Fisher's exact test_Q Fisher's exact test_P Fisher's exact test_Q Fisher's exact test_P Fisher's exact test_Q Fisher's exact test_P Fisher's exact test_Q Fisher's exact test_P Fisher's exact test_Q Fisher's exact test_P Fisher's exact test_Q Fisher's exact test_P Fisher's exact test_Q SPOP 26 (10%) 235 9.9999e-06 0.00338 9.9999e-06 0.00338 0.33563 1 0.28352 1 9.9999e-06 0.00338 9.9999e-06 0.00338 0.96609 1 0.051379 1 0.12606 1 0.35288 1 TP53 23 (9%) 238 9.9999e-06 0.00338 0.32654 1 0.0080499 1 0.0063299 1 0.01085 1 0.01093 1 0.73685 1 0.4123 1 0.085249 1 0.03959 1 PTEN 13 (5%) 248 0.6189 1 0.40554 1 0.2001 1 0.3047 1 0.078009 1 0.064449 1 0.278 1 0.28704 1 0.15087 1 0.074629 1 CTNNB1 9 (3%) 252 0.44304 1 0.062249 1 0.03956 1 0.03844 1 0.32932 1 0.14339 1 0.12554 1 0.04614 1 0.18729 1 0.12714 1 TCEB3 4 (2%) 257 0.64369 1 0.3914 1 0.11563 1 0.62917 1 0.39158 1 0.32708 1 0.15361 1 0.16029 1 0.18059 1 0.43945 1 FOXA1 12 (5%) 249 0.0037 1 0.0161 1 1 1 0.49166 1 0.23758 1 0.02707 1 0.18988 1 0.13482 1 0.19922 1 0.67672 1 BRAF 6 (2%) 255 0.73484 1 0.27344 1 0.83289 1 1 1 0.25171 1 0.0090699 1 0.51763 1 0.52337 1 0.51099 1 0.66342 1 PIK3CA 9 (3%) 252 0.30941 1 0.00411 1 0.04102 1 0.03831 1 0.055749 1 0.00207 0.689 0.10398 1 0.074109 1 0.94845 1 0.21417 1 IDH1 4 (2%) 257 0.04016 1 0.01429 1 0.061879 1 0.051239 1 0.0075399 1 0.0090199 1 0.39188 1 0.03563 1 0.52289 1 0.075429 1 FAM47C 8 (3%) 253 0.41695 1 0.22152 1 1 1 1 1 0.90695 1 0.60217 1 0.49715 1 0.54765 1 0.36746 1 0.26671 1 TP53BP1 5 (2%) 256 0.03373 1 0.10522 1 0.12043 1 0.1497 1 0.44581 1 0.02596 1 1 1 0.28902 1 0.72042 1 0.079209 1 CNTNAP1 5 (2%) 256 0.16813 1 0.076459 1 NA NA NA NA 0.2658 1 0.39214 1 0.73789 1 0.02022 1 NA NA NA NA MLLT10 4 (2%) 257 0.64499 1 0.4709 1 0.55921 1 0.68932 1 1 1 0.68989 1 0.072189 1 0.41612 1 NA NA NA NA ZMYM3 6 (2%) 255 0.53464 1 0.0062199 1 0.44332 1 0.39173 1 0.04019 1 0.14609 1 0.02783 1 0.13987 1 0.04522 1 0.093929 1 SMG7 4 (2%) 257 0.64278 1 0.62835 1 1 1 1 1 0.11346 1 0.0086599 1 0.55636 1 0.23858 1 0.52376 1 0.45248 1 EDC4 3 (1%) 258 0.058969 1 0.27027 1 NA NA NA NA 0.40268 1 0.30947 1 0.51763 1 0.03258 1 0.60065 1 1 1 ZNF709 4 (2%) 257 0.82157 1 0.059289 1 0.45169 1 0.38917 1 0.39401 1 1 1 0.55643 1 0.071619 1 0.88223 1 0.85238 1 CDK12 7 (3%) 254 0.00222 0.737 0.37832 1 0.03983 1 0.03961 1 1 1 0.25536 1 0.30363 1 0.04493 1 0.44055 1 0.92196 1 RPTN 6 (2%) 255 0.11454 1 0.076569 1 0.11504 1 0.11534 1 0.87509 1 0.45113 1 0.5175 1 0.1607 1 0.71221 1 0.95967 1 TNRC18 4 (2%) 257 0.16866 1 0.6966 1 NA NA NA NA 1 1 1 1 0.55493 1 0.59423 1 1 1 1 1 MED15 5 (2%) 256 0.68785 1 0.094119 1 0.44358 1 0.73543 1 0.63107 1 0.44901 1 0.52742 1 0.84369 1 0.5226 1 0.6182 1 NKX3-1 5 (2%) 256 0.47165 1 0.22692 1 0.02826 1 0.051159 1 0.86423 1 0.86644 1 0.32648 1 0.79398 1 NA NA NA NA KDM6A 6 (2%) 255 0.01015 1 0.29124 1 0.83223 1 0.69079 1 0.01351 1 0.25339 1 0.87634 1 0.096469 1 0.59983 1 0.1057 1 RNF31 4 (2%) 257 1 1 0.28025 1 0.67979 1 0.5592 1 0.51924 1 1 1 0.55304 1 0.099209 1 0.51202 1 0.66235 1 ESCO1 4 (2%) 257 0.82054 1 0.28229 1 0.47533 1 0.37787 1 0.20741 1 0.5494 1 0.073779 1 0.77871 1 NA NA NA NA LMOD2 3 (1%) 258 1 1 0.83221 1 NA NA NA NA 1 1 1 1 1 1 1 1 0.29581 1 0.41032 1 FAM120B 3 (1%) 258 0.19826 1 0.27165 1 NA NA NA NA 0.39877 1 0.53195 1 0.77787 1 0.088889 1 NA NA NA NA CLEC1A 4 (2%) 257 0.82046 1 0.31321 1 NA NA NA NA 0.15608 1 0.21428 1 0.47013 1 1 1 NA NA NA NA ITGA2B 3 (1%) 258 1 1 0.32735 1 0.7841 1 0.78134 1 0.643 1 0.30883 1 0.51513 1 0.44319 1 0.43182 1 0.66355 1 RNF17 3 (1%) 258 1 1 0.72474 1 0.01607 1 0.02518 1 0.10994 1 0.11135 1 0.20026 1 0.92045 1 NA NA NA NA RP1L1 7 (3%) 254 0.75057 1 0.76241 1 0.44421 1 0.39033 1 0.71179 1 0.40033 1 0.068879 1 0.35224 1 0.063339 1 0.10521 1 EOMES 4 (2%) 257 0.25049 1 0.7816 1 0.78263 1 0.78112 1 0.26681 1 0.16242 1 1 1 0.43867 1 0.01808 1 0.28973 1 MTF1 3 (1%) 258 0.12769 1 0.62951 1 NA NA NA NA 0.2023 1 0.20607 1 0.64336 1 0.36795 1 NA NA NA NA NTM 5 (2%) 256 1 1 0.44176 1 0.12168 1 0.33128 1 0.32647 1 0.37638 1 0.73595 1 0.57874 1 NA NA NA NA FNBP4 3 (1%) 258 0.33736 1 0.0067599 1 NA NA NA NA 0.3986 1 0.30834 1 0.51503 1 0.13589 1 NA NA NA NA CDKN1B 4 (2%) 257 0.64456 1 0.13988 1 0.24234 1 0.3102 1 0.46326 1 0.11806 1 0.55455 1 0.061729 1 0.51132 1 0.17699 1 EIF2AK3 4 (2%) 257 0.64703 1 0.35243 1 NA NA NA NA 1 1 0.84337 1 0.39206 1 0.94875 1 0.79101 1 0.49826 1 LARP1 3 (1%) 258 0.5524 1 0.26788 1 NA NA NA NA 0.7789 1 1 1 1 1 0.7915 1 NA NA NA NA