rank geneset description genes N_genes mut_tally N n npat nsite nsil n1 n2 n3 n4 n5 n6 p_ns_s p q 1 LONGEVITYPATHWAY Caloric restriction in animals often increases lifespan, which may occur via decreased IGF receptor expression and consequent expression of stress-resistance proteins. AKT1, CAT, FOXO3A, GH1, GHR, HRAS, IGF1, IGF1R, PIK3CA, PIK3R1, SHC1, SOD1, SOD2, SOD3 13 AKT1(1), CAT(2), GHR(1), HRAS(3), IGF1R(1), PIK3CA(10), PIK3R1(1), SHC1(2), SOD2(1), SOD3(1) 5205667 23 22 23 3 7 4 5 5 2 0 0.0683 0.000174 0.107 2 PLCPATHWAY Phospholipase C hydrolyzes the membrane lipid PIP2 to DAG, which activates protein kinase C, and IP3, which causes calcium influx. AKT1, PIK3CA, PIK3R1, PLCB1, PLCG1, PRKCA, PRKCB1, VAV1 7 AKT1(1), PIK3CA(10), PIK3R1(1), PLCB1(2), PLCG1(1), PRKCA(2), VAV1(3) 4997832 20 17 20 2 7 4 2 7 0 0 0.0607 0.00251 0.553 3 AKTPATHWAY Second messenger PIP3 promotes cell survival by activating the anti-apoptotic kinase AKT. AKT1, BAD, CASP9, CHUK, FOXO1A, FOXO3A, GH1, GHR, HSPCA, MLLT7, NFKB1, NFKBIA, PDPK1, PIK3CA, PIK3R1, PPP2CA, RELA, TNFSF6, YWHAH 14 AKT1(1), GHR(1), PDPK1(1), PIK3CA(10), PIK3R1(1), RELA(2), YWHAH(1) 5510447 17 16 17 2 3 6 3 5 0 0 0.0823 0.00269 0.553 4 PTENPATHWAY PTEN suppresses AKT-induced cell proliferation and antagonizes the action of PI3K. AKT1, BCAR1, CDKN1B, FOXO3A, GRB2, ILK, ITGB1, MAPK1, MAPK3, PDK2, PDPK1, PIK3CA, PIK3R1, PTEN, PTK2, SHC1, SOS1, TNFSF6 15 AKT1(1), BCAR1(1), CDKN1B(4), GRB2(1), MAPK1(1), PDPK1(1), PIK3CA(10), PIK3R1(1), PTK2(2), SHC1(2), SOS1(1) 7225206 25 21 25 3 8 6 2 4 5 0 0.0764 0.00579 0.892 5 IGF1RPATHWAY Insulin-like growth factor receptor IGF-1R promotes cell growth and inhibits apoptosis on binding of ligands IGF-1 and 2 via Ras activation and the AKT pathway. AKT1, BAD, GRB2, HRAS, IGF1R, IRS1, MAP2K1, MAPK1, MAPK3, PIK3CA, PIK3R1, RAF1, SHC1, SOS1, YWHAH 15 AKT1(1), GRB2(1), HRAS(3), IGF1R(1), IRS1(2), MAPK1(1), PIK3CA(10), PIK3R1(1), RAF1(1), SHC1(2), SOS1(1), YWHAH(1) 7394322 25 22 25 4 9 5 5 5 1 0 0.0805 0.00836 0.904 6 TRKAPATHWAY Nerve growth factor (NGF) promotes neuronal survival and proliferation by binding its receptor TrkA, which activates PI3K/AKT, Ras, and the MAP kinase pathway. AKT1, DPM2, GRB2, HRAS, KLK2, NGFB, NTRK1, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, SHC1, SOS1 12 AKT1(1), GRB2(1), HRAS(3), KLK2(1), NTRK1(3), PIK3CA(10), PIK3R1(1), PLCG1(1), PRKCA(2), SHC1(2), SOS1(1) 6068612 26 21 26 4 10 7 3 5 1 0 0.0619 0.00881 0.904 7 SA_TRKA_RECEPTOR The TrkA receptor binds nerve growth factor to activate MAP kinase pathways and promote cell growth. AKT1, AKT2, AKT3, ARHA, CDKN1A, ELK1, GRB2, HRAS, MAP2K1, MAP2K2, NGFB, NGFR, NTRK1, PIK3CA, PIK3CD, SHC1, SOS1 15 AKT1(1), AKT2(1), CDKN1A(2), GRB2(1), HRAS(3), NTRK1(3), PIK3CA(10), SHC1(2), SOS1(1) 6320149 24 21 24 4 9 7 3 4 1 0 0.0507 0.0119 1.000 8 ERK5PATHWAY Signaling between a tissue and its innervating axon stimulates retrograde transport via Trk receptors, which activate Erk5, which induces transcription of anti-apoptotic factors. AKT1, CREB1, GRB2, HRAS, MAPK1, MAPK3, MAPK7, MEF2A, MEF2B, MEF2C, MEF2D, NTRK1, PIK3CA, PIK3R1, PLCG1, RPS6KA1, SHC1 17 AKT1(1), GRB2(1), HRAS(3), MAPK1(1), MEF2A(1), MEF2C(2), MEF2D(1), NTRK1(3), PIK3CA(10), PIK3R1(1), PLCG1(1), RPS6KA1(1), SHC1(2) 7409795 28 23 28 4 13 7 4 4 0 0 0.0234 0.0169 1.000 9 RASPATHWAY Ras activation stimulates many signaling cascades, including PI3K/AKT activation to inhibit apoptosis. AKT1, ARHA, BAD, BCL2L1, CASP9, CDC42, CHUK, ELK1, H2AFX, HRAS, MAP2K1, MAPK3, MLLT7, NFKB1, PIK3CA, PIK3R1, RAC1, RAF1, RALA, RALBP1, RALGDS, RELA, RHOA 21 AKT1(1), HRAS(3), PIK3CA(10), PIK3R1(1), RAC1(1), RAF1(1), RALBP1(1), RELA(2) 7441334 20 19 20 3 5 4 6 4 1 0 0.0910 0.0205 1.000 10 SA_G2_AND_M_PHASES Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition. CDC2, CDC25A, CDC25B, CDK7, CDKN1A, CHEK1, NEK1, WEE1 7 CDC25A(1), CDC25B(2), CDKN1A(2), NEK1(2) 2705631 7 7 7 0 6 0 0 0 1 0 0.162 0.0479 1.000 11 ONE_CARBON_POOL_BY_FOLATE ALDH1L1, AMT, ATIC, ATP6V0C, SHMT1, DHFR, GART, MTHFD1, MTHFD1L, MTHFD2, MTHFR, MTHFS, MTR, SHMT1, SHMT2, TYMS 15 ALDH1L1(3), AMT(1), ATIC(2), DHFR(1), GART(1), MTHFD1(2), MTHFD1L(1), MTHFR(2), SHMT1(1), SHMT2(1) 6967054 15 15 15 2 3 4 0 5 3 0 0.168 0.0558 1.000 12 RACCYCDPATHWAY Ras, Rac, and Rho coordinate to induce cyclin D1 expression and activate cdk2 to promote the G1/S transition. AKT1, ARHA, CCND1, CCNE1, CDK2, CDK4, CDK6, CDKN1A, CDKN1B, E2F1, HRAS, MAPK1, MAPK3, NFKB1, NFKBIA, PAK1, PIK3CA, PIK3R1, RAC1, RAF1, RB1, RELA, TFDP1 22 AKT1(1), CDKN1A(2), CDKN1B(4), HRAS(3), MAPK1(1), PIK3CA(10), PIK3R1(1), RAC1(1), RAF1(1), RB1(2), RELA(2), TFDP1(1) 7899573 29 25 29 5 8 4 8 4 4 1 0.122 0.0561 1.000 13 STREPTOMYCIN_BIOSYNTHESIS GCK, HK1, HK2, HK3, IMPA1, PGM1, PGM3, TGDS 8 GCK(3), HK2(1), HK3(2), IMPA1(1), PGM1(1), PGM3(1) 4001165 9 9 9 1 4 1 1 2 1 0 0.162 0.0608 1.000 14 IL10PATHWAY The cytokine IL-10 inhibits the inflammatory response by macrophages via activation of heme oxygenase 1. BLVRA, BLVRB, HMOX1, IL10, IL10RA, IL10RB, IL1A, IL6, JAK1, STAT1, STAT3, STAT5A, TNF 13 BLVRB(1), IL10RA(2), IL6(1), JAK1(3), STAT1(1), STAT3(5), TNF(1) 4756949 14 11 14 2 2 3 2 4 3 0 0.145 0.0775 1.000 15 SRCRPTPPATHWAY Activation of Src by Protein-tyrosine phosphatase alpha CCNB1, CDC2, CDC25A, CDC25B, CDC25C, CSK, GRB2, PRKCA, PRKCB1, PTPRA, SRC 9 CDC25A(1), CDC25B(2), GRB2(1), PRKCA(2), PTPRA(3) 3592415 9 8 9 1 5 2 0 2 0 0 0.147 0.0778 1.000 16 HSA00670_ONE_CARBON_POOL_BY_FOLATE Genes involved in one carbon pool by folate ALDH1L1, AMT, ATIC, DHFR, FTCD, GART, MTFMT, MTHFD1, MTHFD1L, MTHFD2, MTHFR, MTHFS, MTR, SHMT1, SHMT2, TYMS 16 ALDH1L1(3), AMT(1), ATIC(2), DHFR(1), GART(1), MTHFD1(2), MTHFD1L(1), MTHFR(2), SHMT1(1), SHMT2(1) 7388897 15 15 15 2 3 4 0 5 3 0 0.169 0.0790 1.000 17 ACETAMINOPHENPATHWAY Acetaminophen selectively inhibits Cox-3, which is localized to the brain, and yields the toxic metabolite NAPQI when processed by CAR in the liver. CYP1A2, CYP2E1, CYP3A, NR1I3, PTGS1, PTGS2 5 CYP1A2(1), NR1I3(1), PTGS1(1), PTGS2(2) 2076628 5 5 5 1 1 2 0 2 0 0 0.434 0.0809 1.000 18 NUCLEOTIDE_GPCRS ADORA1, ADORA2A, ADORA2B, ADORA3, GPR23, LTB4R, P2RY1, P2RY2, P2RY5, P2RY6 8 ADORA1(2), ADORA2A(1), ADORA3(1), P2RY1(1), P2RY6(1) 2328056 6 6 6 0 4 0 0 2 0 0 0.123 0.0851 1.000 19 FATTY_ACID_BIOSYNTHESIS_PATH_2 ACAA1, ACAA2, ACAT1, ACAT2, ECHS1, EHHADH, HADHA, HADHB, SDS 9 ACAA1(2), ACAA2(1), ACAT1(1), EHHADH(2), HADHB(1) 3258971 7 7 7 0 1 1 1 3 1 0 0.164 0.0856 1.000 20 LEPTINPATHWAY Leptin is a peptide secreted by adipose tissue that, in skeletal muscle, promotes fatty acid oxidation, decreases cells' lipid content, and promotes insulin sensitivity. ACACA, CPT1A, LEP, LEPR, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKAG1, PRKAG2 10 ACACA(4), LEPR(1), PRKAA2(3), PRKAG1(2) 5634582 10 10 10 0 3 0 3 4 0 0 0.0574 0.0859 1.000 21 TERCPATHWAY hTERC, the RNA subunit of telomerase, and hTERT, the catalytic protein subunit, are required for telomerase activity and are overexpressed in many cancers. NFYA, NFYB, NFYC, RB1, SP1, SP3 6 NFYA(1), NFYC(2), RB1(2), SP1(1), SP3(2) 2582385 8 7 8 2 1 2 1 1 2 1 0.462 0.0948 1.000 22 HSA00830_RETINOL_METABOLISM Genes involved in retinol metabolism ALDH1A1, ALDH1A2, BCMO1, RDH5 4 ALDH1A1(1), ALDH1A2(3) 1517642 4 4 3 0 2 0 0 2 0 0 0.303 0.108 1.000 23 HSA00040_PENTOSE_AND_GLUCURONATE_INTERCONVERSIONS Genes involved in pentose and glucuronate interconversions AKR1B1, DCXR, GUSB, RPE, UGDH, UGP2, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, XYLB 25 UGDH(1), UGP2(1), UGT1A4(1), UGT1A7(1), UGT1A8(2), UGT1A9(1), UGT2A1(1), UGT2A3(1), UGT2B10(2), UGT2B11(2), UGT2B15(1), UGT2B17(1), UGT2B28(2), UGT2B7(1) 10605012 18 16 18 1 3 1 2 8 4 0 0.0618 0.108 1.000 24 NGFPATHWAY Nerve growth factor (NGF) stimulates neural survival and proliferation via the TrkA and p75 receptors, which induce DAG and IP3 production and activate Ras. CSNK2A1, DPM2, ELK1, FOS, GRB2, HRAS, JUN, KLK2, MAP2K1, MAPK3, MAPK8, NGFB, NGFR, PIK3CA, PIK3R1, PLCG1, RAF1, SHC1, SOS1 18 GRB2(1), HRAS(3), KLK2(1), PIK3CA(10), PIK3R1(1), PLCG1(1), RAF1(1), SHC1(2), SOS1(1) 7423408 21 19 21 4 9 3 4 4 1 0 0.182 0.110 1.000 25 ETCPATHWAY Energy is extracted from carbohydrates via oxidation and transferred to the mitochondrial electron transport chain, which couples ATP synthesis to the reduction of oxygen to water. ATP5A1, CYCS, GPD2, MTCO1, NDUFA1, SDHA, SDHB, SDHC, SDHD, UQCRC1 9 ATP5A1(2), SDHA(1), SDHC(1), UQCRC1(1) 2577129 5 5 5 0 0 1 1 1 2 0 0.244 0.115 1.000 26 SA_G1_AND_S_PHASES Cdk2, 4, and 6 bind cyclin D in G1, while cdk2/cyclin E promotes the G1/S transition. ARF1, ARF3, CCND1, CDK2, CDK4, CDKN1A, CDKN1B, CDKN2A, CFL1, E2F1, E2F2, MDM2, NXT1, PRB1, TP53 14 CDKN1A(2), CDKN1B(4), CDKN2A(1), CFL1(1), MDM2(1) 3002865 9 7 9 1 2 0 0 0 7 0 0.649 0.122 1.000 27 HSA00521_STREPTOMYCIN_BIOSYNTHESIS Genes involved in streptomycin biosynthesis GCK, HK1, HK2, HK3, IMPA1, IMPA2, ISYNA1, PGM1, PGM3, TGDS 10 GCK(3), HK2(1), HK3(2), IMPA1(1), PGM1(1), PGM3(1) 4575404 9 9 9 1 4 1 1 2 1 0 0.152 0.131 1.000 28 HSA00680_METHANE_METABOLISM Genes involved in methane metabolism ADH5, CAT, EPX, LPO, MPO, MTHFR, PRDX6, SHMT1, SHMT2, TPO 10 CAT(2), EPX(1), LPO(1), MTHFR(2), SHMT1(1), SHMT2(1), TPO(1) 4541092 9 9 9 1 3 4 1 0 1 0 0.124 0.133 1.000 29 IL18PATHWAY Pro-inflammatory IL-18 is activated in macrophages by caspase-1 cleavage and, in conjunction with IL-12, stimulates Th1 cell differentiation. CASP1, IFNG, IL12A, IL12B, IL18, IL2 6 CASP1(2), IL12A(1) 1158749 3 3 3 1 1 0 0 1 1 0 0.685 0.136 1.000 30 EIF4PATHWAY The eIF-4F complex recognizes 5' mRNA caps, recruits RNA helicases, and maintains mRNA-ribosome bridging. AKT1, EIF4A1, EIF4A2, EIF4E, EIF4EBP1, EIF4G1, EIF4G2, EIF4G3, FRAP1, GHR, IRS1, MAPK1, MAPK14, MAPK3, MKNK1, PABPC1, PDK2, PDPK1, PIK3CA, PIK3R1, PRKCA, PRKCB1, PTEN, RPS6KB1 21 AKT1(1), EIF4A1(1), EIF4G1(1), EIF4G2(1), EIF4G3(2), GHR(1), IRS1(2), MAPK1(1), PDPK1(1), PIK3CA(10), PIK3R1(1), PRKCA(2) 10668129 24 21 24 3 5 4 2 10 3 0 0.0994 0.142 1.000 31 P53HYPOXIAPATHWAY Hypoxia induces p53 accumulation and consequent apoptosis with p53-mediated cell cycle arrest, which is present under conditions of DNA damage. ABCB1, AKT1, ATM, BAX, CDKN1A, CPB2, CSNK1A1, CSNK1D, FHL2, GADD45A, HIC1, HIF1A, HSPA1A, HSPCA, IGFBP3, MAPK8, MDM2, NFKBIB, NQO1, TP53 17 ABCB1(4), AKT1(1), CDKN1A(2), CPB2(1), HIC1(3), MDM2(1), NQO1(1) 5367301 13 10 13 1 7 2 1 0 3 0 0.0719 0.143 1.000 32 HSA00472_D_ARGININE_AND_D_ORNITHINE_METABOLISM Genes involved in D-arginine and D-ornithine metabolism DAO 1 DAO(1) 282382 1 1 1 1 1 0 0 0 0 0 0.919 0.154 1.000 33 IGF1PATHWAY Growth factor IGF-1 stimulates growth and inhibits apoptosis by activating the MAP kinase pathway in a variety of cell types. CSNK2A1, ELK1, FOS, GRB2, HRAS, IGF1, IGF1R, IRS1, JUN, MAP2K1, MAPK3, MAPK8, PIK3CA, PIK3R1, PTPN11, RAF1, RASA1, SHC1, SOS1, SRF 20 GRB2(1), HRAS(3), IGF1R(1), IRS1(2), PIK3CA(10), PIK3R1(1), RAF1(1), SHC1(2), SOS1(1) 9640973 22 19 22 4 8 3 5 5 1 0 0.150 0.157 1.000 34 ANDROGEN_AND_ESTROGEN_METABOLISM AKR1C4, AKR1D1, ARSB, ARSD, ARSE, CYP11B1, CYP11B2, HSD11B1, HSD11B2, HSD17B2, HSD17B3, HSD17B8, HSD3B1, HSD3B2, SRD5A1, SRD5A2, STS, SULT1E1, SULT2A1, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4 30 AKR1C4(1), AKR1D1(1), ARSB(1), ARSE(2), CYP11B1(1), CYP11B2(1), HSD11B1(1), HSD17B3(1), STS(1), SULT1E1(2), UGT1A4(1), UGT1A7(1), UGT1A8(2), UGT1A9(1), UGT2B15(1) 10644504 18 16 18 1 5 3 1 4 5 0 0.0205 0.159 1.000 35 MITRPATHWAY The MyoD/MEF2 transcription factors induce muscle cell differentiation and are repressed by the transcriptional repressor MITR. CAMK1, CAMK1G, HDAC9, MEF2A, MEF2B, MEF2C, MEF2D, MYOD1, YWHAH 9 CAMK1(2), CAMK1G(1), HDAC9(1), MEF2A(1), MEF2C(2), MEF2D(1), YWHAH(1) 3019972 9 8 9 2 5 1 1 2 0 0 0.329 0.160 1.000 36 ARFPATHWAY Cyclin-dependent kinase inhibitor 2A is a tumor suppressor that induces G1 arrest and can activate the p53 pathway, leading to G2/M arrest. ABL1, CDKN2A, E2F1, MDM2, MYC, PIK3CA, PIK3R1, POLR1A, POLR1B, POLR1C, POLR1D, RAC1, RB1, TBX2, TP53, TWIST1 15 ABL1(4), CDKN2A(1), MDM2(1), PIK3CA(10), PIK3R1(1), POLR1B(1), POLR1C(1), RAC1(1), RB1(2) 7610078 22 16 22 3 4 2 5 6 4 1 0.135 0.163 1.000 37 VALINE_LEUCINE_AND_ISOLEUCINE_BIOSYNTHESIS BCAT1, IARS, LARS, LARS2, PDHA1, PDHA2, PDHB 7 BCAT1(1), IARS(1), LARS(1), LARS2(2), PDHA2(2) 3897402 7 7 7 0 2 1 1 2 1 0 0.115 0.165 1.000 38 HSA00643_STYRENE_DEGRADATION Genes involved in styrene degradation FAH, GSTZ1, HGD 3 FAH(1), HGD(1) 866929 2 2 2 0 0 0 0 0 2 0 0.475 0.183 1.000 39 HSA00532_CHONDROITIN_SULFATE_BIOSYNTHESIS Genes involved in chondroitin sulfate biosynthesis B3GALT6, B3GAT1, B3GAT2, B3GAT3, B4GALT7, ChGn, CHPF, CHST11, CHST12, CHST13, CHST14, CHST3, CHST7, CHSY-2, CHSY1, CSGlcA-T, DSE, GALNAC4S-6ST, GALNACT-2, UST, XYLT1, XYLT2 16 B3GAT1(1), B3GAT3(2), CHPF(1), CHST11(1), CHSY1(1), DSE(1), UST(1), XYLT1(4), XYLT2(1) 5521977 13 13 13 1 7 1 0 3 2 0 0.0538 0.191 1.000 40 FOSBPATHWAY FOSB gene expression and drug abuse CDK5, FOSB, GRIA2, JUND, PPP1R1B 5 GRIA2(2), JUND(1) 1473756 3 3 3 1 1 0 1 1 0 0 0.640 0.191 1.000 41 CDC42RACPATHWAY PI3 kinase stimulates cell migration by activating cdc42, which activates ARP2/3, which in turn promotes formation of new actin fibers. ACTR2, ACTR3, ARHA, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, CDC42, PAK1, PDGFRA, PIK3CA, PIK3R1, RAC1, WASL 14 ACTR3(1), PDGFRA(2), PIK3CA(10), PIK3R1(1), RAC1(1) 5210738 15 14 15 3 5 2 3 5 0 0 0.304 0.194 1.000 42 C21_STEROID_HORMONE_METABOLISM AKR1C4, AKR1D1, CYP11A1, CYP11B1, CYP11B2, CYP17A1, CYP21A2, HSD11B1, HSD11B2, HSD3B1, HSD3B2 11 AKR1C4(1), AKR1D1(1), CYP11B1(1), CYP11B2(1), CYP21A2(1), HSD11B1(1) 3623006 6 6 6 0 1 2 0 1 2 0 0.0843 0.197 1.000 43 HSA00140_C21_STEROID_HORMONE_METABOLISM Genes involved in C21-steroid hormone metabolism AKR1C4, AKR1D1, CYP11A1, CYP11B1, CYP11B2, CYP17A1, CYP21A2, HSD11B1, HSD11B2, HSD3B1, HSD3B2 11 AKR1C4(1), AKR1D1(1), CYP11B1(1), CYP11B2(1), CYP21A2(1), HSD11B1(1) 3623006 6 6 6 0 1 2 0 1 2 0 0.0843 0.197 1.000 44 SULFUR_METABOLISM BPNT1, PAPSS1, PAPSS2, SULT1A2, SULT1A3, SULT1A3, SULT1A4, SULT1E1, SULT2A1, SUOX 7 BPNT1(2), PAPSS2(1), SULT1E1(2) 2370538 5 5 5 0 3 1 0 0 1 0 0.248 0.200 1.000 45 PGC1APATHWAY PCG-1a is expressed in skeletal muscle, heart muscle, and brown fat, and is a coactivator for receptors such as glucocorticoid receptor and thyroid hormone receptor. CALM1, CALM2, CALM3, CAMK1, CAMK1G, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, ESRRA, HDAC5, MEF2A, MEF2B, MEF2C, MEF2D, PPARA, PPARGC1, PPP3CA, PPP3CB, PPP3CC, SLC2A4, SYT1, YWHAH 23 CAMK1(2), CAMK1G(1), CAMK2A(1), CAMK2D(1), CAMK4(2), HDAC5(2), MEF2A(1), MEF2C(2), MEF2D(1), PPARA(2), PPP3CA(1), PPP3CC(1), SYT1(1), YWHAH(1) 7912912 19 16 19 3 9 1 1 6 2 0 0.153 0.201 1.000 46 CDMACPATHWAY Cadmium 2+ promotes cell proliferation in cultured macrophages by entering the cell via calcium channels and activating the MAP kinase pathway. CUZD1, FOS, HRAS, JUN, MAP2K1, MAPK1, MAPK3, MYC, NFKB1, NFKBIA, PLCB1, PRKCA, PRKCB1, RAF1, RELA, TNF 15 HRAS(3), MAPK1(1), PLCB1(2), PRKCA(2), RAF1(1), RELA(2), TNF(1) 6062873 12 11 12 1 6 2 3 1 0 0 0.0532 0.205 1.000 47 HSA00627_1,4_DICHLOROBENZENE_DEGRADATION Genes involved in 1,4-dichlorobenzene degradation CMBL 1 CMBL(1) 197830 1 1 1 0 0 0 0 0 1 0 0.607 0.206 1.000 48 NEUROTRANSMITTERSPATHWAY Biosynthesis of neurotransmitters DBH, GAD1, HDC, PNMT, TH, TPH1 6 DBH(3), PNMT(1), TPH1(1) 2382824 5 5 5 0 2 1 1 1 0 0 0.161 0.211 1.000 49 SA_REG_CASCADE_OF_CYCLIN_EXPR Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases. CCNA1, CCNA2, CCND1, CCNE1, CCNE2, CDK2, CDK4, CDKN1B, CDKN2A, E2F1, E2F2, E2F4, PRB1 13 CCNA1(1), CCNE2(1), CDKN1B(4), CDKN2A(1) 3538360 7 7 7 1 0 1 0 1 5 0 0.668 0.224 1.000 50 CAPROLACTAM_DEGRADATION AKR1A1, ECHS1, EHHADH, HADHA, SDS 5 AKR1A1(1), EHHADH(2) 1889897 3 3 3 0 0 1 0 2 0 0 0.436 0.233 1.000 51 FCER1PATHWAY In mast cells, Fc epsilon receptor 1 activates BTK, PKC, and the MAP kinase pathway to promote degranulation and arachnidonic acid release. BTK, CALM1, CALM2, CALM3, ELK1, FCER1A, FCER1G, FOS, GRB2, HRAS, JUN, LYN, MAP2K1, MAP2K4, MAP2K7, MAP3K1, MAPK1, MAPK3, MAPK8, NFATC1, NFATC2, NFATC3, NFATC4, PAK2, PIK3CA, PIK3R1, PLA2G4A, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCB1, RAF1, SHC1, SOS1, SYK, SYT1, VAV1 37 BTK(1), FCER1A(1), GRB2(1), HRAS(3), MAP2K4(1), MAP2K7(2), MAPK1(1), NFATC1(1), NFATC2(1), PAK2(1), PIK3CA(10), PIK3R1(1), PLA2G4A(2), PLCG1(1), PPP3CA(1), PPP3CC(1), RAF1(1), SHC1(2), SOS1(1), SYK(2), SYT1(1), VAV1(3) 16759350 39 34 39 6 15 4 5 14 1 0 0.0358 0.235 1.000 52 NEUTROPHILPATHWAY Neutrophils are phagocytotic leukocytes that destroy foreign cells with reactive oxygen species or enzymatic digestion and express CD11 and CD18. CD44, ICAM1, ITGAL, ITGAM, ITGB2, PECAM1, SELE, SELL 8 ITGAL(3), ITGAM(2), ITGB2(2), SELE(1) 4063705 8 7 8 1 4 1 1 2 0 0 0.169 0.236 1.000 53 INSULINPATHWAY Insulin regulates glucose levels via Ras-mediated transcriptional activation. CSNK2A1, ELK1, FOS, GRB2, HRAS, INS, INSR, IRS1, JUN, MAP2K1, MAPK3, MAPK8, PIK3CA, PIK3R1, PTPN11, RAF1, RASA1, SHC1, SLC2A4, SOS1, SRF 21 GRB2(1), HRAS(3), IRS1(2), PIK3CA(10), PIK3R1(1), RAF1(1), SHC1(2), SOS1(1) 9923806 21 19 21 4 8 3 4 5 1 0 0.181 0.249 1.000 54 SELENOAMINO_ACID_METABOLISM AHCY, CBS, CTH, GGT1, MARS, MARS2, MAT1A, MAT2B, PAPSS1, PAPSS2, SCLY, SEPHS1 12 AHCY(1), CBS(1), CTH(1), MARS2(1), MAT1A(1), PAPSS2(1), SEPHS1(1) 4834451 7 7 7 1 1 2 1 0 3 0 0.349 0.250 1.000 55 PKCPATHWAY Gq-coupled receptors promote hydrolysis of PIP2 to DAG and IP3, which causes calcium influx and activates protein kinase C. GNAQ, NFKB1, NFKBIA, PLCB1, PRKCA, PRKCB1, RELA 6 PLCB1(2), PRKCA(2), RELA(2) 3218922 6 6 6 0 2 2 1 1 0 0 0.108 0.251 1.000 56 CDK5PATHWAY Cdk5, a regulatory kinase implicated in neuronal development, represses Mek1, which downregulates the MAP kinase pathway. CDK5, CDK5R1, DPM2, EGR1, HRAS, KLK2, MAP2K1, MAP2K2, MAPK1, MAPK3, NGFB, NGFR, RAF1 12 EGR1(1), HRAS(3), KLK2(1), MAPK1(1), RAF1(1) 3223084 7 7 7 2 4 0 2 0 1 0 0.541 0.254 1.000 57 HSA00660_C5_BRANCHED_DIBASIC_ACID_METABOLISM Genes involved in C5-branched dibasic acid metabolism ILVBL, SUCLA2 2 ILVBL(2) 824590 2 2 2 0 0 0 0 1 1 0 0.809 0.262 1.000 58 RECKPATHWAY RECK is a membrane-anchored inhibitor of matrix metalloproteinases, which are expressed by tumor cells and promote metastasis. HRAS, MMP14, MMP2, MMP9, RECK, TIMP1, TIMP2, TIMP3, TIMP4 9 HRAS(3), MMP14(1), MMP9(1) 2932749 5 5 5 0 2 0 2 1 0 0 0.196 0.264 1.000 59 PANTOTHENATE_AND_COA_BIOSYNTHESIS BCAT1, COASY, DPYD, DPYS, ENPP1, ENPP3, PANK1, PANK2, PANK3, PANK4, PPCS, UPB1 12 BCAT1(1), DPYD(2), DPYS(1), ENPP1(2), ENPP3(1), PANK1(2), PANK2(2), PANK3(1) 5450841 12 12 11 3 2 3 2 2 3 0 0.475 0.267 1.000 60 HSA00785_LIPOIC_ACID_METABOLISM Genes involved in lipoic acid metabolism LIAS, LIPT1, LOC387787 2 LIPT1(1) 593383 1 1 1 0 0 1 0 0 0 0 0.718 0.269 1.000 61 HBXPATHWAY Hbx is a hepatitis B protein that activates a number of transcription factors, possibly by inducing calcium release from the mitochondrion to the cytoplasm. CREB1, GRB2, HBXIP, HRAS, PTK2B, SHC1, SOS1, SRC 8 GRB2(1), HRAS(3), SHC1(2), SOS1(1) 3436806 7 7 7 2 5 1 1 0 0 0 0.450 0.272 1.000 62 CHONDROITIN B3GAT3, B4GALT7, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, XYLT1, XYLT2 8 B3GAT3(2), XYLT1(4), XYLT2(1) 2601843 7 7 7 1 3 1 0 1 2 0 0.265 0.275 1.000 63 HEPARAN_SULFATE_BIOSYNTHESIS B3GAT3, B4GALT7, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, XYLT1, XYLT2 8 B3GAT3(2), XYLT1(4), XYLT2(1) 2601843 7 7 7 1 3 1 0 1 2 0 0.265 0.275 1.000 64 HSA00592_ALPHA_LINOLENIC_ACID_METABOLISM Genes involved in alpha-Linolenic acid metabolism ACOX1, ACOX3, FADS2, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6 15 ACOX3(1), PLA2G12B(1), PLA2G2A(1), PLA2G4A(2), PLA2G6(1) 3966667 6 6 6 1 1 0 1 3 1 0 0.484 0.278 1.000 65 ST_PAC1_RECEPTOR_PATHWAY The signaling peptide PACAP binds to its receptor, PAC1R, which activates adenylyl cyclase and phospholipase C. ASAH1, CAMP, DAG1, GAS, GNAQ, ITPKA, ITPKB, PACAP 6 ASAH1(1), DAG1(1), ITPKB(2) 2378201 4 4 4 0 1 1 0 2 0 0 0.265 0.286 1.000 66 CDC25PATHWAY The protein phosphatase Cdc25 is phosphorylated by Chk1 and activates Cdc2 to stimulate eukaryotic cells into M phase. ATM, CDC2, CDC25A, CDC25B, CDC25C, CHEK1, MYT1, WEE1, YWHAH 7 CDC25A(1), CDC25B(2), MYT1(1), YWHAH(1) 2923489 5 5 5 0 3 1 0 1 0 0 0.180 0.289 1.000 67 HSA00920_SULFUR_METABOLISM Genes involved in sulfur metabolism BPNT1, CHST11, CHST12, CHST13, PAPSS1, PAPSS2, SULT1A1, SULT1A2, SULT1A3, SULT1A4, SULT1E1, SULT2A1, SULT2B1, SUOX 12 BPNT1(2), CHST11(1), PAPSS2(1), SULT1A1(2), SULT1E1(2) 3603600 8 7 8 0 5 1 0 0 2 0 0.0493 0.290 1.000 68 HSA00062_FATTY_ACID_ELONGATION_IN_MITOCHONDRIA Genes involved in fatty acid elongation in mitochondria ACAA2, ECHS1, HADH, HADHA, HADHB, HSD17B10, HSD17B4, MECR, PPT1, PPT2 10 ACAA2(1), HADH(1), HADHB(1), HSD17B4(1), PPT2(1) 3304064 5 5 5 0 2 1 0 1 1 0 0.169 0.297 1.000 69 ARENRF2PATHWAY Nrf1 and nrf2 are transcription factors that bind to antioxidant response elements (AREs), promoters of genes involved in oxidative damage control. CREB1, FOS, FXYD2, JUN, KEAP1, MAFF, MAFG, MAFK, MAPK1, MAPK14, MAPK8, NFE2L2, PRKCA, PRKCB1 13 KEAP1(3), MAFF(1), MAPK1(1), PRKCA(2) 3479471 7 7 7 0 3 1 1 2 0 0 0.0838 0.305 1.000 70 HSA00130_UBIQUINONE_BIOSYNTHESIS Genes involved in ubiquinone biosynthesis COQ2, COQ3, COQ5, COQ6, COQ7, ND1, ND2, ND3, ND4, ND4L, ND5, ND6, NDUFA12, NDUFA13, NDUFB11 8 COQ3(1), COQ7(1) 1569387 2 2 2 1 0 1 1 0 0 0 0.761 0.315 1.000 71 ASBCELLPATHWAY B cells require interaction with helper T cells to produce antigen-specific immunoglobulins as a key element of the human immune response. CD28, CD4, CD80, HLA-DRA, HLA-DRB1, IL10, IL2, IL4, TNFRSF5, TNFRSF6, TNFSF5, TNFSF6 8 HLA-DRA(1), IL4(1) 1546474 2 2 2 0 2 0 0 0 0 0 0.487 0.319 1.000 72 HSA00601_GLYCOSPHINGOLIPID_BIOSYNTHESIS_LACTOSERIES Genes involved in glycosphingolipid biosynthesis - lactoseries ABO, B3GALT1, B3GALT2, B3GALT5, B3GNT5, FUT1, FUT2, FUT3, ST3GAL3, ST3GAL4 10 B3GALT2(1), B3GALT5(2), FUT1(1), FUT2(1), FUT3(1) 2809126 6 6 6 2 1 2 0 3 0 0 0.640 0.320 1.000 73 ACHPATHWAY Nicotinic acetylcholine receptors are ligand-gated ion channels that primarily mediate neuromuscular signaling and may inhibit neuronal apoptosis via the AKT pathway. AKT1, BAD, CHRNB1, CHRNG, FOXO3A, MUSK, PIK3CA, PIK3R1, PTK2, PTK2B, RAPSN, SRC, TERT, TNFSF6, YWHAH 13 AKT1(1), MUSK(2), PIK3CA(10), PIK3R1(1), PTK2(2), YWHAH(1) 6416599 17 14 17 3 5 6 2 4 0 0 0.117 0.321 1.000 74 SA_B_CELL_RECEPTOR_COMPLEXES Antigen binding to B cell receptors activates protein tyrosine kinases, such as the Src family, which ultimate activate MAP kinases. ATF2, BCR, BLNK, ELK1, FOS, GRB2, HRAS, JUN, LYN, MAP2K1, MAP3K1, MAPK1, MAPK3, MAPK8IP3, PAPPA, RAC1, RPS6KA1, RPS6KA3, SHC1, SOS1, SYK, VAV1, VAV2, VAV3 24 ATF2(1), BCR(1), GRB2(1), HRAS(3), MAPK1(1), MAPK8IP3(2), PAPPA(3), RAC1(1), RPS6KA1(1), SHC1(2), SOS1(1), SYK(2), VAV1(3), VAV2(1), VAV3(1) 12515702 24 22 24 4 11 2 4 6 1 0 0.0776 0.347 1.000 75 PLCDPATHWAY Phospholipase C (PLC-d1) hydrolyzes the membrane lipid PIP2 to DAG and IP3, which induce calcium influx and activates protein kinase C. ADRA1B, PLCD1, PRKCA, PRKCB1, TGM2 4 ADRA1B(2), PRKCA(2) 1941501 4 4 4 0 1 1 0 1 1 0 0.297 0.350 1.000 76 HSA00565_ETHER_LIPID_METABOLISM Genes involved in ether lipid metabolism AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPAT6, AGPS, CHPT1, ENPP2, ENPP6, LYCAT, PAFAH1B1, PAFAH1B2, PAFAH1B3, PAFAH2, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLD1, PLD2, PPAP2A, PPAP2B, PPAP2C 30 AGPAT2(1), AGPAT3(2), AGPAT4(1), AGPAT6(2), ENPP2(3), PLA2G12B(1), PLA2G2A(1), PLA2G4A(2), PLA2G6(1), PLD1(2), PPAP2A(1), PPAP2B(1) 9066246 18 15 18 2 6 1 0 6 5 0 0.109 0.350 1.000 77 OVARIAN_INFERTILITY_GENES ATM, BMPR1B, CCND2, CDK4, CDKN1B, CEBPB, DAZL, DMC1, EGR1, ESR2, FSHR, GJA4, INHA, LHCGR, MLH1, MSH5, NCOR1, NR5A1, NRIP1, PGR, PRLR, PTGER2, SMPD1, VDR, ZP2 24 CDKN1B(4), CEBPB(1), EGR1(1), FSHR(1), GJA4(1), INHA(1), LHCGR(1), MLH1(1), NCOR1(6), NRIP1(1), PGR(1) 11239314 19 16 19 2 3 1 2 1 12 0 0.240 0.352 1.000 78 IL5PATHWAY Pro-inflammatory IL-5 is secretes by activated T cells, eosinophils, and mast cells, and stimulates the proliferation and activation of eosinophils in bone marrow. CCL11, CCR3, CD4, HLA-DRA, HLA-DRB1, IL1B, IL4, IL5, IL5RA, IL6 10 HLA-DRA(1), IL4(1), IL6(1) 2077769 3 3 3 0 2 1 0 0 0 0 0.259 0.355 1.000 79 BETAOXIDATIONPATHWAY Beta-Oxidation of Fatty Acids ACADL, ACADM, ACADS, ACAT1, ECHS1, HADHA 6 ACADS(2), ACAT1(1) 2108004 3 3 2 0 2 0 0 1 0 0 0.362 0.355 1.000 80 CYTOKINEPATHWAY Intercellular signaling in the immune system occurs via secretion of cytokines, which promote antigen-dependent B and T cell response. IFNA1, IFNB1, IFNG, IL10, IL12A, IL12B, IL13, IL14, IL15, IL16, IL17, IL18, IL1A, IL2, IL3, IL4, IL5, IL6, IL8, IL9, LTA, TNF 20 IL12A(1), IL16(2), IL4(1), IL6(1), IL9(1), TNF(1) 3862971 7 6 7 1 2 1 1 2 1 0 0.253 0.367 1.000 81 HSA00361_GAMMA_HEXACHLOROCYCLOHEXANE_DEGRADATION Genes involved in gamma-hexachlorocyclohexane degradation ACP1, ACP2, ACP5, ACP6, ACPP, ACPT, ALPI, ALPL, ALPP, ALPPL2, CMBL, CYP3A4, CYP3A43, CYP3A5, CYP3A7, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, PON1, PON2, PON3 23 ACP5(1), ACPT(1), ALPI(1), ALPP(1), ALPPL2(1), CMBL(1), CYP3A43(1), CYP3A7(1), DHRS1(1), DHRS7(1), DHRSX(1), PON1(1), PON2(2) 7051429 14 11 14 2 5 1 2 3 3 0 0.0798 0.369 1.000 82 ST_DICTYOSTELIUM_DISCOIDEUM_CAMP_CHEMOTAXIS_PATHWAY The fungus Dictyostelium discoideum is a model system for cytoskeletal organization during chemotaxis. ACTR2, ACTR3, AKT1, ANGPTL2, BF, DAG1, DGKA, ETFA, GCA, ITGA9, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, MAP2K1, MAPK1, MAPK3, NR1I3, PAK1, PDE3A, PDE3B, PI3, PIK3C2G, PIK3CA, PIK3CD, PIK3R1, PLDN, PSME1, RIPK3, RPS4X, SGCB, VASP 32 ACTR3(1), AKT1(1), DAG1(1), DGKA(1), ETFA(1), ITGA9(2), ITPKB(2), ITPR1(2), ITPR2(3), ITPR3(1), MAPK1(1), NR1I3(1), PDE3B(1), PIK3CA(10), PIK3R1(1), PSME1(1) 19043170 30 27 30 3 7 8 3 7 5 0 0.0169 0.372 1.000 83 TALL1PATHWAY APRIL and BAFF bind to BCMA and TACI receptors on B cell surfaces, promoting immunoglobulin production and cell proliferation. CHUK, MAP3K14, MAPK14, MAPK8, NFKB1, RELA, TNFRSF13B, TNFRSF13C, TNFRSF17, TNFSF13, TNFSF13B, TRAF2, TRAF3, TRAF5, TRAF6 15 RELA(2), TNFRSF13B(2), TRAF2(3), TRAF5(1) 5681674 8 7 8 1 2 2 1 2 1 0 0.206 0.372 1.000 84 HSA00290_VALINE_LEUCINE_AND_ISOLEUCINE_BIOSYNTHESIS Genes involved in valine, leucine and isoleucine biosynthesis BCAT1, BCAT2, IARS, IARS2, ILVBL, LARS, LARS2, PDHA1, PDHA2, PDHB, VARS, VARS2 12 BCAT1(1), IARS(1), ILVBL(2), LARS(1), LARS2(2), PDHA2(2), VARS(2), VARS2(2) 7269956 13 11 13 2 3 1 1 5 3 0 0.312 0.377 1.000 85 GLEEVECPATHWAY The drug Gleevec specifically targets the abnormal bcr-abl protein, an apoptosis inhibitor present in chronic myeloid leukemia. AKT1, BCL2, BCR, CRKL, FOS, GRB2, HRAS, JAK2, JUN, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, MYC, PIK3CA, PIK3R1, RAF1, SOS1, STAT1, STAT5A, STAT5B 22 AKT1(1), BCR(1), GRB2(1), HRAS(3), MAP2K4(1), PIK3CA(10), PIK3R1(1), RAF1(1), SOS1(1), STAT1(1), STAT5B(1) 10976025 22 20 22 4 6 5 5 6 0 0 0.126 0.382 1.000 86 NKCELLSPATHWAY Natural killer (NK) lymphocytes are inhibited by MHC and activated by surface glycoproteins on tumor or virus-infected cells, which undergo perforin-mediated lysis. B2M, HLA-A, IL18, ITGB1, KLRC1, KLRC2, KLRC3, KLRC4, KLRD1, LAT, MAP2K1, MAPK3, PAK1, PIK3CA, PIK3R1, PTK2B, PTPN6, RAC1, SYK, VAV1 20 B2M(1), PIK3CA(10), PIK3R1(1), RAC1(1), SYK(2), VAV1(3) 7247813 18 17 18 4 6 2 3 7 0 0 0.329 0.389 1.000 87 BBCELLPATHWAY Fas ligand expression by T cells induces apoptosis in Fas-expressing, inactive B cells. CD28, CD4, HLA-DRA, HLA-DRB1, TNFRSF5, TNFRSF6, TNFSF5, TNFSF6 4 HLA-DRA(1) 923917 1 1 1 0 1 0 0 0 0 0 0.692 0.391 1.000 88 SMALL_LIGAND_GPCRS C9orf47, CNR1, CNR2, DNMT1, EDG1, EDG2, EDG5, EDG6, MTNR1A, MTNR1B, PTAFR, PTGDR, PTGER1, PTGER2, PTGER4, PTGFR, PTGIR, TBXA2R 13 CNR1(2), DNMT1(2), MTNR1A(1), MTNR1B(1), PTGIR(1), TBXA2R(2) 4400245 9 8 9 2 6 2 0 0 1 0 0.152 0.393 1.000 89 METHANE_METABOLISM ADH5, ATP6V0C, SHMT1, CAT, EPX, LPO, MPO, PRDX1, PRDX2, PRDX5, PRDX6, SHMT1, SHMT2, TPO 13 CAT(2), EPX(1), LPO(1), SHMT1(1), SHMT2(1), TPO(1) 4620099 7 7 7 1 2 3 1 0 1 0 0.241 0.398 1.000 90 ST_PHOSPHOINOSITIDE_3_KINASE_PATHWAY The phosphoinositide-3 kinase pathway produces the lipid second messenger PIP3 and regulates cell growth, survival, and movement. A1BG, AKT1, AKT2, AKT3, BAD, BTK, CDKN2A, CSL4, DAF, DAPP1, FOXO1A, GRB2, GSK3A, GSK3B, IARS, IGFBP1, INPP5D, P14, PDK1, PIK3CA, PPP1R13B, PSCD3, PTEN, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SFN, SHC1, SOS1, SOS2, TEC, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ 32 A1BG(1), AKT1(1), AKT2(1), BTK(1), CDKN2A(1), GRB2(1), GSK3A(2), GSK3B(1), IARS(1), INPP5D(2), PDK1(1), PIK3CA(10), PPP1R13B(1), RPS6KA1(1), SHC1(2), SOS1(1), YWHAH(1), YWHAQ(1) 13791797 30 27 30 5 9 6 3 7 5 0 0.0687 0.402 1.000 91 METHIONINEPATHWAY Catabolic Pathways for Methionine, Isoleucine, Threonine and Valine BCKDHB, BCKDK, CBS, CTH, MUT 5 CBS(1), CTH(1), MUT(1) 1915637 3 3 3 0 1 0 0 0 2 0 0.682 0.409 1.000 92 TUBBYPATHWAY Tubby is activated by phospholipase C activity and hydrolysis of PIP2, after which it enters the nucleus and regulates transcription. CHRM1, GNAQ, GNB1, GNGT1, HTR2C, PLCB1, TUB 7 GNB1(1), GNGT1(1), HTR2C(2), PLCB1(2), TUB(1) 2789375 7 6 7 2 3 1 1 2 0 0 0.488 0.411 1.000 93 HSA00232_CAFFEINE_METABOLISM Genes involved in caffeine metabolism CYP1A2, CYP2A13, CYP2A6, CYP2A7, NAT1, NAT2, XDH 7 CYP1A2(1), CYP2A13(1), CYP2A6(2) 3102703 4 4 4 1 2 0 1 0 1 0 0.677 0.412 1.000 94 TGFBPATHWAY The TGF-beta receptor responds to ligand binding by activating the SMAD family of transcriptional regulations, commonly blocking cell growth. APC, CDH1, CREBBP, EP300, MADH2, MADH3, MADH4, MADH7, MADHIP, MAP2K1, MAP3K7, MAP3K7IP1, MAPK3, SKIL, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2 13 APC(2), CDH1(4), CREBBP(4), EP300(4), MAP3K7(2), TGFB1(1), TGFB2(1), TGFBR1(2) 10014559 20 17 20 3 6 0 3 6 5 0 0.212 0.414 1.000 95 MTORPATHWAY Mammalian target of rapamycin (mTOR) senses mitogenic factors and nutrients, including ATP, and induces cell proliferation. AKT1, EIF3S10, EIF4A1, EIF4A2, EIF4B, EIF4E, EIF4EBP1, EIF4G1, EIF4G2, EIF4G3, FKBP1A, FRAP1, MKNK1, PDK2, PDPK1, PIK3CA, PIK3R1, PPP2CA, PTEN, RPS6, RPS6KB1, TSC1, TSC2 20 AKT1(1), EIF4A1(1), EIF4G1(1), EIF4G2(1), EIF4G3(2), PDPK1(1), PIK3CA(10), PIK3R1(1), TSC2(2) 10488594 20 18 20 3 4 4 2 8 2 0 0.146 0.415 1.000 96 CXCR4PATHWAY CXCR4 is a G-protein coupled receptor that responds to the ligand SDF-1 by activating Ras and PI3 kinase to promote lymphocyte chemotaxis. BCAR1, CRK, CXCL12, CXCR4, GNAI1, GNAQ, GNB1, GNGT1, HRAS, MAP2K1, MAPK1, MAPK3, NFKB1, PIK3C2G, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, PTK2, PTK2B, PXN, RAF1, RELA 23 BCAR1(1), CRK(1), GNAI1(1), GNB1(1), GNGT1(1), HRAS(3), MAPK1(1), PIK3CA(10), PIK3R1(1), PLCG1(1), PRKCA(2), PTK2(2), PXN(1), RAF1(1), RELA(2) 10790164 29 23 29 5 10 4 6 8 1 0 0.0940 0.421 1.000 97 UBIQUINONE_BIOSYNTHESIS NDUFA1, NDUFA10, NDUFA11, NDUFA4, NDUFA5, NDUFA8, NDUFB2, NDUFB4, NDUFB5, NDUFB6, NDUFB7, NDUFS1, NDUFS2, NDUFV1, NDUFV2 15 NDUFA10(2), NDUFB7(1), NDUFV1(1) 2719329 4 4 4 1 1 0 3 0 0 0 0.532 0.422 1.000 98 BOTULINPATHWAY Blockade of Neurotransmitter Relase by Botulinum Toxin CHRM1, CHRNA1, SNAP25, STX1A, VAMP2 5 SNAP25(2) 1267396 2 2 2 1 1 0 0 1 0 0 0.837 0.429 1.000 99 P27PATHWAY p27 blocks the G1/S transition by inhibiting the checkpoint kinase cdk2/cyclin E and is inhibited by cdk2-mediated ubiquitination. CCNE1, CDK2, CDKN1B, CKS1B, CUL1, E2F1, NEDD8, RB1, RBX1, SKP1A, SKP2, TFDP1, UBE2M 12 CDKN1B(4), RB1(2), TFDP1(1) 3337134 7 6 7 2 0 0 2 0 4 1 0.821 0.436 1.000 100 1_AND_2_METHYLNAPHTHALENE_DEGRADATION ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1 7 ADH1B(1), ADH4(1), ADH6(1) 2189340 3 3 3 0 1 0 1 1 0 0 0.348 0.437 1.000 101 PAR1PATHWAY Activated extracellular thrombin cleaves and activates the G-protein coupled receptors PAR1 and PAR4, which activate platelets. ADCY1, ARHA, ARHGEF1, F2, F2R, F2RL3, GNA12, GNA13, GNAI1, GNAQ, GNB1, GNGT1, MAP3K7, PIK3CA, PIK3R1, PLCB1, PPP1R12B, PRKCA, PRKCB1, PTK2B, ROCK1 19 ADCY1(1), ARHGEF1(3), F2(1), GNA13(1), GNAI1(1), GNB1(1), GNGT1(1), MAP3K7(2), PIK3CA(10), PIK3R1(1), PLCB1(2), PRKCA(2), ROCK1(5) 10085979 31 26 30 6 8 4 6 10 3 0 0.186 0.440 1.000 102 CALCINEURINPATHWAY Increased intracellular calcium activates the phosphatase calcineurin in differentiating keratinocytes. CALM1, CALM2, CALM3, CDKN1A, GNAQ, MARCKS, NFATC1, NFATC2, NFATC3, NFATC4, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, SP1, SP3, SYT1 18 CDKN1A(2), MARCKS(1), NFATC1(1), NFATC2(1), PLCG1(1), PPP3CA(1), PPP3CC(1), PRKCA(2), SP1(1), SP3(2), SYT1(1) 8174078 14 12 14 1 5 1 1 5 2 0 0.0775 0.446 1.000 103 PTC1PATHWAY The binding of extracellular signaling protein Sonic hedgehog to the Patched receptor (Ptc1) allows progression through G1 and may inhibit the G2/M transition. CCNB1, CCNH, CDC2, CDC25A, CDC25B, CDC25C, CDK7, MNAT1, PTCH, SHH, XPO1 9 CDC25A(1), CDC25B(2), SHH(2) 3376913 5 5 5 1 4 0 1 0 0 0 0.381 0.448 1.000 104 BILE_ACID_BIOSYNTHESIS ACAA1, ACAA2, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AKR1C4, AKR1D1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, BAAT, CEL, CYP27A1, CYP7A1, HADHB, SOAT2, SRD5A1, SRD5A2 27 ACAA1(2), ACAA2(1), ADH1B(1), ADH4(1), ADH6(1), AKR1C4(1), AKR1D1(1), ALDH1A1(1), ALDH1A2(3), ALDH1A3(1), ALDH3A1(1), CYP7A1(1), HADHB(1), SOAT2(1) 9067469 17 16 16 3 4 1 4 6 2 0 0.187 0.451 1.000 105 HSA00930_CAPROLACTAM_DEGRADATION Genes involved in caprolactam degradation AKR1A1, ASAHL, ECHS1, EHHADH, HADH, HADHA, HSD17B10, HSD17B4, NTAN1, SIRT1, SIRT2, SIRT5, SIRT7, VNN2, VNN3 13 AKR1A1(1), EHHADH(2), HADH(1), HSD17B4(1), SIRT1(1), SIRT2(1) 4619080 7 7 7 2 1 3 0 2 1 0 0.529 0.452 1.000 106 PHENYLALANINE_TYROSINE_AND_TRYPTOPHAN_BIOSYNTHESIS ENO1, ENO2, ENO3, FARS2, FARSLB, GOT1, GOT2, PAH, TAT, YARS 9 ENO1(2), GOT1(1), PAH(1) 3228664 4 4 4 0 2 0 0 1 1 0 0.298 0.455 1.000 107 VOBESITYPATHWAY The adipose tissue of obese individuals overexpresses a key glucocorticoid-metabolizing enzyme, activating inactive circulating corticosteroids and inducing insulin resistance. APM1, HSD11B1, LPL, NR3C1, PPARG, RETN, RXRA, TNF 7 HSD11B1(1), PPARG(1), TNF(1) 2257008 3 3 3 1 1 0 1 0 1 0 0.668 0.461 1.000 108 MONOCYTEPATHWAY Monocytes are a class of immune phagocytes that can develop into macrophages and express LFA-1, CD44, and other surface signaling proteins. CD44, ICAM1, ITGA4, ITGAL, ITGAM, ITGB1, ITGB2, PECAM1, SELE, SELL, SELP 11 ITGAL(3), ITGAM(2), ITGB2(2), SELE(1), SELP(2) 6220463 10 9 10 2 5 1 2 2 0 0 0.227 0.463 1.000 109 EICOSANOID_SYNTHESIS ALOX12, ALOX15, ALOX15B, ALOX5, ALOX5AP, DPEP1, GGT1, IPLA2(GAMMA), LTA4H, LTC4S, PLA2G2A, PLA2G6, PTGDS, PTGES, PTGIS, PTGS1, PTGS2, TBXAS1 17 ALOX15(1), DPEP1(2), PLA2G2A(1), PLA2G6(1), PTGS1(1), PTGS2(2) 5906728 8 8 8 0 2 2 0 4 0 0 0.0701 0.464 1.000 110 PELP1PATHWAY Pelp1 acts downstream of activated estrogen receptor to promote cell proliferation and is overexpressed in many breast tumors. CREBBP, EP300, ESR1, MAPK1, MAPK3, PELP1, SRC 7 CREBBP(4), EP300(4), ESR1(1), MAPK1(1), PELP1(1) 5781106 11 10 11 2 6 0 1 2 2 0 0.268 0.475 1.000 111 HSA03010_RIBOSOME Genes involved in ribosome C15orf15, FAU, hCG_1644323, hCG_1984468, hCG_2041321, hCG_21078, hCG_26523, LOC283412, LOC284064, LOC284230, LOC284288, LOC284393, LOC285053, LOC342994, LOC347292, LOC388720, LOC389342, LOC390876, LOC391656, LOC400652, LOC402057, LOC439992, LOC440055, LOC440589, LOC440733, LOC440737, LOC441377, LOC441876, LOC441907, MRPL13, MRPS7, RPL10A, RPL10L, RPL11, RPL12, RPL13, RPL13A, RPL14, RPL18, RPL18A, RPL19, RPL21, RPL22L1, RPL23A, RPL23AP2, RPL24, RPL26, RPL27, RPL27A, RPL28, RPL29, RPL3, RPL30, RPL31, RPL32, RPL34, RPL35, RPL35A, RPL36A, RPL36AL, RPL37, RPL37A, RPL38, RPL39, RPL3L, RPL41, RPL6, RPL7, RPL8, RPL9, RPS10, RPS11, RPS12, RPS13, RPS15A, RPS16, RPS18, RPS2, RPS20, RPS21, RPS23, RPS24, RPS25, RPS26, RPS26P10, RPS27, RPS28, RPS29, RPS3, RPS3A, RPS4Y1, RPS5, RPS6, RPS7, RPS8, RPS9, RPSA, tcag7.23 67 RPL10A(1), RPL11(2), RPL19(2), RPL28(1), RPL3(1), RPL37(1), RPL8(1), RPS11(2), RPS9(1) 8924203 12 12 12 1 2 2 0 5 3 0 0.284 0.478 1.000 112 TPOPATHWAY Thrombopoietin binds to its receptor and activates cell growth through the Erk and JNK MAP kinase pathways, protein kinase C, and JAK/STAT activation. CSNK2A1, FOS, GRB2, HRAS, JAK2, JUN, MAP2K1, MAPK3, MPL, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, RAF1, RASA1, SHC1, SOS1, STAT1, STAT3, STAT5A, STAT5B, THPO 22 GRB2(1), HRAS(3), PIK3CA(10), PIK3R1(1), PLCG1(1), PRKCA(2), RAF1(1), SHC1(2), SOS1(1), STAT1(1), STAT3(5), STAT5B(1) 11677760 29 23 29 5 10 5 5 8 1 0 0.0888 0.494 1.000 113 HSA00272_CYSTEINE_METABOLISM Genes involved in cysteine metabolism CARS, CARS2, CDO1, CTH, GOT1, GOT2, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, MPST, SDS, SULT1B1, SULT1C2, SULT1C4, SULT4A1 17 CARS(1), CARS2(2), CTH(1), GOT1(1), SULT4A1(1) 4897323 6 6 6 0 2 0 0 2 2 0 0.318 0.496 1.000 114 AMINOSUGARS_METABOLISM CMAS, CYB5R3, GCK, GFPT1, GNE, GNPDA1, GNPDA2, HEXA, HEXB, HK1, HK2, HK3, PGM3, RENBP, UAP1 15 GCK(3), HEXB(1), HK2(1), HK3(2), PGM3(1) 6618411 8 8 8 1 4 0 0 2 2 0 0.322 0.499 1.000 115 FEEDERPATHWAY Sugars such as mannose, galactose, and fructose are enzymatically converted to glucose via feeder pathways that lead to glycolysis. HK1, KHK, LCT, MPI, PGM1, PYGL, PYGM, TPI1, TREH 9 LCT(3), PGM1(1), PYGL(2), TREH(1) 5244556 7 7 7 1 3 2 1 1 0 0 0.211 0.501 1.000 116 RBPATHWAY The ATM protein kinase recognizes DNA damage and blocks cell cycle progression by phosphorylating chk1 and p53, which normally inhibits Rb to allow G1/S transitions. ATM, CDC2, CDC25A, CDC25B, CDC25C, CDK2, CDK4, CHEK1, MYT1, RB1, TP53, WEE1, YWHAH 10 CDC25A(1), CDC25B(2), MYT1(1), RB1(2), YWHAH(1) 4081412 7 7 7 2 3 1 1 1 0 1 0.519 0.501 1.000 117 STEMPATHWAY In the absence of infection, bone marrow stromal cells release hematopoietic cytokines; activated macrophages and Th cells induce hematopoiesis during infection. CD4, CD8A, CSF1, CSF2, CSF3, EPO, IL11, IL2, IL3, IL4, IL5, IL6, IL7, IL8, IL9 15 CD8A(1), IL4(1), IL6(1), IL7(1), IL9(1) 2377944 5 5 5 2 1 1 1 1 1 0 0.686 0.503 1.000 118 GLYOXYLATE_AND_DICARBOXYLATE_METABOLISM ACO1, ACO2, CS, GRHPR, HAO1, HAO2, HYI, MDH1, MDH2, MTHFD1, MTHFD1L, MTHFD2 12 ACO2(1), HAO1(2), MTHFD1(2), MTHFD1L(1) 4981067 6 6 6 0 1 2 1 2 0 0 0.129 0.503 1.000 119 G2PATHWAY Activated Cdc2-cyclin B kinase regulates the G2/M transition; DNA damage stimulates the DNA-PK/ATM/ATR kinases, which inactivate Cdc2. ATM, ATR, BRCA1, CCNB1, CDC2, CDC25A, CDC25B, CDC25C, CDC34, CDKN1A, CDKN2D, CHEK1, CHEK2, EP300, GADD45A, MDM2, MYT1, PLK, PRKDC, RPS6KA1, TP53, WEE1, YWHAH, YWHAQ 20 CDC25A(1), CDC25B(2), CDKN1A(2), EP300(4), MDM2(1), MYT1(1), PRKDC(7), RPS6KA1(1), YWHAH(1), YWHAQ(1) 13557806 21 17 21 2 10 4 1 4 2 0 0.0442 0.504 1.000 120 SIG_IL4RECEPTOR_IN_B_LYPHOCYTES Genes related to IL4 rceptor signaling in B lymphocytes AKT1, AKT2, AKT3, BAD, BCL2, GRB2, GSK3A, GSK3B, IL4R, IRS1, IRS2, JAK1, JAK3, MAP4K1, MAPK1, MAPK3, PDK1, PIK3CA, PIK3CD, PIK3R1, PPP1R13B, RAF1, SHC1, SOCS1, SOS1, SOS2, STAT6 27 AKT1(1), AKT2(1), GRB2(1), GSK3A(2), GSK3B(1), IL4R(2), IRS1(2), IRS2(1), JAK1(3), MAP4K1(1), MAPK1(1), PDK1(1), PIK3CA(10), PIK3R1(1), PPP1R13B(1), RAF1(1), SHC1(2), SOS1(1), STAT6(2) 14363833 35 29 35 7 10 5 3 10 7 0 0.163 0.512 1.000 121 GSK3PATHWAY Bacterial lipopolysaccharide activates AKT to promote the survival and activation of macrophages and inhibits Gsk3-beta to promote beta-catenin accumulation in the nucleus. AKT1, APC, AXIN1, CCND1, CD14, CTNNB1, DVL1, FZD1, GJA1, GNAI1, GSK3B, IRAK1, LBP, LEF1, LY96, MYD88, NFKB1, PDPK1, PIK3CA, PIK3R1, PPP2CA, PRKR, RELA, TIRAP, TLR4, TOLLIP, WNT1 25 AKT1(1), APC(2), FZD1(2), GJA1(1), GNAI1(1), GSK3B(1), IRAK1(1), LEF1(1), PDPK1(1), PIK3CA(10), PIK3R1(1), RELA(2) 11406655 24 22 24 5 7 6 5 4 2 0 0.112 0.514 1.000 122 EOSINOPHILSPATHWAY Recruitment of eosinophils in the inflammatory response observed in asthma occurs via the chemoattractant eotaxin binding to the CCR3 receptor. CCL11, CCL5, CCR3, CSF2, HLA-DRA, HLA-DRB1, IL3, IL5 8 HLA-DRA(1) 1185332 1 1 1 0 1 0 0 0 0 0 0.686 0.515 1.000 123 TERTPATHWAY hTERC, the RNA subunit of telomerase, and hTERT, the catalytic protein subunit, are required for telomerase activity and are overexpressed in many cancers. HDAC1, MAX, MYC, SP1, SP3, TP53, WT1, ZNF42 6 SP1(1), SP3(2) 2434734 3 3 3 1 0 1 0 1 1 0 0.740 0.516 1.000 124 LYSINE_BIOSYNTHESIS AADAT, AASDH, AASDHPPT, AASS, KARS 5 AADAT(1), AASDH(1), KARS(1) 2700380 3 3 3 0 0 0 1 2 0 0 0.459 0.517 1.000 125 SIG_BCR_SIGNALING_PATHWAY Members of the BCR signaling pathway AKT1, AKT2, AKT3, BAD, BCL2, BCR, BLNK, BTK, CD19, CD22, CD81, CR2, CSK, DAG1, FLOT1, FLOT2, GRB2, GSK3A, GSK3B, INPP5D, ITPR1, ITPR2, ITPR3, LYN, MAP4K1, MAPK1, MAPK3, NFATC1, NFATC2, NR0B2, PDK1, PIK3CA, PIK3CD, PIK3R1, PLCG2, PPP1R13B, PPP3CA, PPP3CB, PPP3CC, PTPRC, RAF1, SHC1, SOS1, SOS2, SYK, VAV1 46 AKT1(1), AKT2(1), BCR(1), BTK(1), CD81(1), DAG1(1), GRB2(1), GSK3A(2), GSK3B(1), INPP5D(2), ITPR1(2), ITPR2(3), ITPR3(1), MAP4K1(1), MAPK1(1), NFATC1(1), NFATC2(1), PDK1(1), PIK3CA(10), PIK3R1(1), PLCG2(1), PPP1R13B(1), PPP3CA(1), PPP3CC(1), PTPRC(3), RAF1(1), SHC1(2), SOS1(1), SYK(2), VAV1(3) 28955902 50 44 50 6 17 6 7 13 7 0 0.00471 0.518 1.000 126 ERBB4PATHWAY ErbB4 (aka HER4) is a receptor tyrosine kinase that binds neuregulins as well as members of the EGF family, which also target EGF receptors. ADAM17, ERBB4, NRG2, NRG3, PRKCA, PRKCB1, PSEN1 6 ERBB4(1), NRG2(1), NRG3(2), PRKCA(2) 3518220 6 5 6 1 2 1 0 1 2 0 0.469 0.524 1.000 127 HSA00363_BISPHENOL_A_DEGRADATION Genes involved in bisphenol A degradation AKR1B10, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, HSD3B7, PON1, PON2, PON3, RDH11, RDH12, RDH13, RDH14 14 DHRS1(1), DHRS7(1), DHRSX(1), PON1(1), PON2(2), RDH12(1) 3521278 7 5 7 0 3 0 1 2 1 0 0.101 0.525 1.000 128 TCYTOTOXICPATHWAY Cytotoxic T cells release perforin and granzyme to lyse foreign cell targets and express Fas ligand to promote Fas-induced apoptosis. CD2, CD28, CD3D, CD3E, CD3G, CD3Z, CD8A, ICAM1, ITGAL, ITGB2, PTPRC, THY1, TRA@, TRB@ 11 CD8A(1), ITGAL(3), ITGB2(2), PTPRC(3) 4185544 9 8 9 3 3 1 1 3 1 0 0.444 0.532 1.000 129 HYPERTROPHY_MODEL ADAM10, ANKRD1, ATF3, CYR61, DUSP14, EIF4E, EIF4EBP1, GDF8, HBEGF, IFNG, IFRD1, IL18, IL1A, IL1R1, JUND, MYOG, NR4A3, TCF8, VEGF, WDR1 17 ADAM10(1), CYR61(1), JUND(1), WDR1(1) 4209067 4 4 4 0 0 0 3 0 1 0 0.339 0.537 1.000 130 BENZOATE_DEGRADATION_VIA_COA_LIGATION ACAT1, ACAT2, ACYP1, ACYP2, ECHS1, EHHADH, GCDH, HADHA, SDHB, SDS 10 ACAT1(1), EHHADH(2) 3046292 3 3 3 0 0 1 0 2 0 0 0.447 0.537 1.000 131 RIBOFLAVIN_METABOLISM ACP1, ACP2, ACP5, ACPP, ACPT, ENPP1, ENPP3, FLAD1, RFK, TYR 10 ACP5(1), ACPT(1), ENPP1(2), ENPP3(1), RFK(1) 3783439 6 6 6 2 1 1 1 1 2 0 0.541 0.537 1.000 132 HSA04140_REGULATION_OF_AUTOPHAGY Genes involved in regulation of autophagy ATG12, ATG3, ATG5, ATG7, BECN1, GABARAP, GABARAPL1, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNG, INS, LOC441925, PIK3C3, PIK3R4, PRKAA1, PRKAA2, ULK1, ULK2, ULK3 29 ATG12(1), ATG5(1), ATG7(1), IFNA10(1), IFNA13(1), IFNA16(1), PIK3R4(1), PRKAA2(3), ULK3(1) 8259581 11 11 11 2 5 0 2 3 1 0 0.275 0.540 1.000 133 MALATEXPATHWAY The tricarboxylate transfer pathway shuttles acetyl groups of acetyl-CoA between mitochondria and the cytoplasm. ACLY, CS, MDH1, ME1, PC, PDHA1, SLC25A1, SLC25A11 8 ACLY(1), ME1(2), PC(1) 3614609 4 4 4 1 0 1 0 1 2 0 0.537 0.541 1.000 134 HSA00630_GLYOXYLATE_AND_DICARBOXYLATE_METABOLISM Genes involved in glyoxylate and dicarboxylate metabolism ACO1, ACO2, AFMID, CS, GRHPR, HAO1, HAO2, HYI, LOC441996, MDH1, MDH2, MTHFD1, MTHFD1L, MTHFD2 13 ACO2(1), HAO1(2), MTHFD1(2), MTHFD1L(1) 5218175 6 6 6 0 1 2 1 2 0 0 0.128 0.552 1.000 135 PARKINPATHWAY In Parkinson's disease, dopaminergic neurons contain Lewy bodies consisting of alpha-synuclein and parkin, an E3 ubiquitin ligase that targets glycosylated alpha-synuclein. GPR37, PARK2, PNUTL1, SNCA, SNCAIP, UBE2E2, UBE2F, UBE2G1, UBE2G2, UBE2L3, UBE2L6, UBL1 10 PARK2(1), SNCAIP(2) 2506017 3 3 3 1 1 0 0 2 0 0 0.734 0.562 1.000 136 GPCRDB_CLASS_A_RHODOPSIN_LIKE2 CYSLTR1, CYSLTR2, GPR109B, GPR161, GPR171, GPR18, GPR34, GPR39, GPR41, GPR42, GPR45, GPR65, GPR68, GPR75, GPR81, LYPDC1 13 CYSLTR2(1), GPR171(1), GPR18(1), GPR68(1), GPR75(1) 3806376 5 5 5 0 2 1 0 2 0 0 0.160 0.563 1.000 137 HSA00730_THIAMINE_METABOLISM Genes involved in thiamine metabolism LHPP, MTMR1, MTMR2, MTMR6, NFS1, PHPT1, THTPA, TPK1 8 NFS1(1), THTPA(2) 2499223 3 3 3 1 1 0 1 0 1 0 0.671 0.563 1.000 138 HSA00603_GLYCOSPHINGOLIPID_BIOSYNTHESIS_GLOBOSERIES Genes involved in glycosphingolipid biosynthesis - globoseries A4GALT, B3GALNT1, B3GALT5, FUT1, FUT2, FUT9, GBGT1, GLA, HEXA, HEXB, NAGA, ST3GAL1, ST3GAL2, ST8SIA1 14 A4GALT(2), B3GALNT1(1), B3GALT5(2), FUT1(1), FUT2(1), HEXB(1), ST3GAL1(2), ST8SIA1(1) 4197075 11 11 11 4 6 2 0 1 2 0 0.582 0.565 1.000 139 HSA00642_ETHYLBENZENE_DEGRADATION Genes involved in ethylbenzene degradation ARD1A, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ESCO1, ESCO2, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1 12 DHRS1(1), DHRS7(1), DHRSX(1), ESCO1(4), NAT6(1) 6443010 8 8 8 0 2 0 0 2 4 0 0.134 0.573 1.000 140 HSA00300_LYSINE_BIOSYNTHESIS Genes involved in lysine biosynthesis AADAT, AASDHPPT, AASS, KARS 4 AADAT(1), KARS(1) 1830493 2 2 2 0 0 0 1 1 0 0 0.556 0.573 1.000 141 TERPENOID_BIOSYNTHESIS FDFT1, FDPS, FDPS, LOC402397, IDI1, SQLE 4 SQLE(1) 1231979 1 1 1 1 1 0 0 0 0 0 0.887 0.581 1.000 142 HSA00770_PANTOTHENATE_AND_COA_BIOSYNTHESIS Genes involved in pantothenate and CoA biosynthesis BCAT1, BCAT2, COASY, DPYD, DPYS, ENPP1, ENPP3, ILVBL, PANK1, PANK2, PANK3, PANK4, PPCDC, PPCS, UPB1, VNN1 16 BCAT1(1), DPYD(2), DPYS(1), ENPP1(2), ENPP3(1), ILVBL(2), PANK1(2), PANK2(2), PANK3(1) 6770091 14 14 13 4 2 3 2 3 4 0 0.583 0.583 1.000 143 CYSTEINE_METABOLISM CARS, CTH, GOT1, GOT2, LDHA, LDHB, LDHC, MPST 8 CARS(1), CTH(1), GOT1(1) 2670986 3 3 3 0 1 0 0 1 1 0 0.580 0.589 1.000 144 GAMMA_HEXACHLOROCYCLOHEXANE_DEGRADATION ACP1, ACP2, ACP5, ACPP, ACPT, ALPI, ALPL, ALPP, ALPP, ALPPL2, ALPPL2, CYP19A1, CYP1A1, CYP1A2, CYP2A6, CYP2A6, CYP2A7, CYP2A7P1, CYP2A13, CYP2B6, CYP2C18, CYP2C19, CYP2C19, CYP2C9, CYP2C8, CYP2C9, CYP2D6, CYP2E1, CYP2F1, CYP2J2, CYP3A4, CYP3A5, CYP3A7, CYP4B1, CYP4F8, CYP51A1, PON1 31 ACP5(1), ACPT(1), ALPI(1), ALPP(1), ALPPL2(1), CYP19A1(2), CYP1A1(1), CYP1A2(1), CYP2A13(1), CYP2A6(2), CYP2B6(2), CYP2C18(1), CYP2C8(3), CYP2F1(2), CYP3A7(1), PON1(1) 11458328 22 19 22 4 9 2 5 2 4 0 0.104 0.595 1.000 145 PENTOSE_AND_GLUCURONATE_INTERCONVERSIONS AKR1B1, DCXR, GUSB, RPE, RPE, LOC440001, UCHL1, UCHL3, UGDH, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4 18 UGDH(1), UGT1A4(1), UGT1A7(1), UGT1A8(2), UGT1A9(1), UGT2B15(1) 6846087 7 7 7 1 2 0 1 2 2 0 0.448 0.596 1.000 146 REELINPATHWAY Reelin is secreted by neurons and recognized by receptors including cadherin related neuronal receptors, which promote phosphorylation of Dab1. CDK5, CDK5R1, DAB1, FYN, LRP8, RELN, VLDLR 7 DAB1(2), LRP8(1), RELN(3), VLDLR(2) 5458873 8 8 8 2 2 1 2 2 1 0 0.481 0.596 1.000 147 SA_PTEN_PATHWAY PTEN is a tumor suppressor that dephosphorylates the lipid messenger phosphatidylinositol triphosphate. AKT1, AKT2, AKT3, BPNT1, GRB2, ILK, MAPK1, MAPK3, PDK1, PIK3CA, PIK3CD, PIP3-E, PTEN, PTK2B, RBL2, SHC1, SOS1 15 AKT1(1), AKT2(1), BPNT1(2), GRB2(1), MAPK1(1), PDK1(1), PIK3CA(10), RBL2(1), SHC1(2), SOS1(1) 7649406 21 19 21 5 8 4 3 5 1 0 0.275 0.597 1.000 148 SA_FAS_SIGNALING The TNF-type receptor Fas induces apoptosis on ligand binding. BCL2, CASP3, CASP8, CFL1, CFLAR, P11, PDE6D, TNFRSF6, TNFSF6 6 CFL1(1) 1510568 1 1 1 0 0 0 0 0 1 0 1.000 0.597 1.000 149 PENTOSE_PHOSPHATE_PATHWAY ALDOA, ALDOB, ALDOC, FBP1, FBP2, G6PD, GPI, H6PD, PFKM, PFKP, PGD, PGLS, PGM1, PGM3, PRPS1, PRPS1L1, PRPS2, RBKS, RPE, RPE, LOC440001, RPIA, TAL1, TALDO1, TALDO1, HSUP1, TKT 23 ALDOC(1), H6PD(2), PFKM(1), PFKP(1), PGM1(1), PGM3(1), PRPS1L1(2), RBKS(2), TKT(1) 7993694 12 12 12 2 3 0 3 4 2 0 0.366 0.599 1.000 150 PTDINSPATHWAY Phosphoinositide 3 kinase (PI3K) phosphorylate inositol rings of phosphoinositide lipids, influencing vesicle trafficking, cell proliferation, and migration. AKT1, AP2A1, AP2M1, ARF1, BAD, BTK, EEA1, GRASP, GSK3A, GSK3B, LYN, PDPK1, PFKL, PFKM, PFKP, PFKX, PLCG1, PRKCE, PRKCZ, RAB5A, RAC1, RPS6KB1, VAV2 22 AKT1(1), BTK(1), EEA1(2), GSK3A(2), GSK3B(1), PDPK1(1), PFKL(1), PFKM(1), PFKP(1), PLCG1(1), PRKCZ(2), RAC1(1), VAV2(1) 9836530 16 16 16 3 3 3 2 6 2 0 0.196 0.599 1.000 151 HSA00534_HEPARAN_SULFATE_BIOSYNTHESIS Genes involved in heparan sulfate biosynthesis EXT1, EXT2, EXTL1, EXTL2, EXTL3, GLCE, HS2ST1, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, HS3ST5, HS6ST1, HS6ST2, HS6ST3, LOC728969, NDST1, NDST2, NDST3, NDST4 19 EXT1(1), EXT2(2), EXTL1(2), EXTL3(2), GLCE(1), HS6ST1(1), NDST1(2), NDST2(2), NDST4(3) 8097450 16 14 16 3 3 4 4 5 0 0 0.151 0.599 1.000 152 EDG1PATHWAY The lipid S1P is an EDG1 ligand promoting chemotaxis via Rac1 and cell survival and proliferation via ERK activation. ADCY1, AKT1, ARHA, ASAH1, EDG1, GNAI1, GNB1, GNGT1, ITGAV, ITGB3, MAPK1, MAPK3, PDGFA, PDGFRA, PIK3CA, PIK3R1, PLCB1, PRKCA, PRKCB1, PTK2, RAC1, SKIP, SMPD1, SMPD2, SPHK1, SRC 22 ADCY1(1), AKT1(1), ASAH1(1), GNAI1(1), GNB1(1), GNGT1(1), ITGAV(2), MAPK1(1), PDGFRA(2), PIK3CA(10), PIK3R1(1), PLCB1(2), PRKCA(2), PTK2(2), RAC1(1) 10700424 29 22 29 5 9 5 4 9 2 0 0.104 0.600 1.000 153 CIRCADIANPATHWAY A heterodimer composed of Bmal1 and Clock acts as a transcription factor for proteins that regulate circadian rhythms, such as Per and Cry. ARNTL, CLOCK, CRY1, CRY2, CSNK1E, PER1 6 CRY2(2), CSNK1E(1), PER1(1) 3337669 4 4 4 0 1 0 1 2 0 0 0.341 0.602 1.000 154 HSA00401_NOVOBIOCIN_BIOSYNTHESIS Genes involved in novobiocin biosynthesis GOT1, GOT2, TAT 3 GOT1(1) 1024487 1 1 1 0 0 0 0 1 0 0 0.830 0.613 1.000 155 ATP_SYNTHESIS ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H 21 ATP6V1A(2), ATP6V1B1(1), ATP6V1C2(3), ATP6V1F(1), ATP6V1H(1), SHMT1(1) 5848963 9 9 9 2 1 1 0 5 2 0 0.660 0.616 1.000 156 FLAGELLAR_ASSEMBLY ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H 21 ATP6V1A(2), ATP6V1B1(1), ATP6V1C2(3), ATP6V1F(1), ATP6V1H(1), SHMT1(1) 5848963 9 9 9 2 1 1 0 5 2 0 0.660 0.616 1.000 157 TYPE_III_SECRETION_SYSTEM ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H 21 ATP6V1A(2), ATP6V1B1(1), ATP6V1C2(3), ATP6V1F(1), ATP6V1H(1), SHMT1(1) 5848963 9 9 9 2 1 1 0 5 2 0 0.660 0.616 1.000 158 CYANOAMINO_ACID_METABOLISM ATP6V0C, SHMT1, GBA3, GGT1, SHMT1, SHMT2 5 SHMT1(1), SHMT2(1) 1629376 2 2 2 0 1 1 0 0 0 0 0.392 0.622 1.000 159 CREMPATHWAY The transcription factor CREM activates a post-meiotic transcriptional cascade culminating in spermatogenesis. ADCY1, CREM, FHL5, FSHB, FSHR, GNAS, XPO1 7 ADCY1(1), CREM(1), FHL5(1), FSHR(1), GNAS(2) 3725944 6 5 6 2 1 0 2 3 0 0 0.782 0.624 1.000 160 IFNGPATHWAY IFN gamma signaling pathway IFNG, IFNGR1, IFNGR2, JAK1, JAK2, STAT1 6 JAK1(3), STAT1(1) 3190719 4 3 4 1 0 1 0 2 1 0 0.703 0.633 1.000 161 METPATHWAY The hepatocyte growth factor receptor c-Met stimulates proliferation and alters cell motility and adhesion on binding the ligand HGF. ACTA1, CRK, CRKL, DOCK1, ELK1, FOS, GAB1, GRB2, GRF2, HGF, HRAS, ITGA1, ITGB1, JUN, MAP2K1, MAP2K2, MAP4K1, MAPK1, MAPK3, MAPK8, MET, PAK1, PIK3CA, PIK3R1, PTEN, PTK2, PTK2B, PTPN11, PXN, RAF1, RAP1A, RAP1B, RASA1, SOS1, SRC, STAT3 34 CRK(1), GRB2(1), HGF(2), HRAS(3), MAP4K1(1), MAPK1(1), MET(1), PIK3CA(10), PIK3R1(1), PTK2(2), PXN(1), RAF1(1), SOS1(1), STAT3(5) 16955484 31 27 31 5 10 6 6 8 1 0 0.0419 0.646 1.000 162 CTLA4PATHWAY T cell activation requires interaction with an antigen-MHC-I complex on an antigen-presenting cell (APC), as well as CD28 interaction with the APC's CD80 or 86. CD28, CD3D, CD3E, CD3G, CD3Z, CD80, CD86, CTLA4, GRB2, HLA-DRA, HLA-DRB1, ICOS, ICOSL, IL2, ITK, LCK, PIK3CA, PIK3R1, PTPN11, TRA@, TRB@ 17 GRB2(1), HLA-DRA(1), ITK(1), PIK3CA(10), PIK3R1(1) 4980432 14 12 14 4 6 2 2 4 0 0 0.536 0.646 1.000 163 HSA00960_ALKALOID_BIOSYNTHESIS_II Genes involved in alkaloid biosynthesis II AADAC, ABP1, AOC2, AOC3, ARD1A, CES1, CES7, DDHD1, ESCO1, ESCO2, LIPA, LYCAT, MYST3, MYST4, NAT5, NAT6, PLA1A, PNPLA3, PPME1, PRDX6, SH3GLB1 18 AADAC(1), AOC2(1), CES1(1), DDHD1(3), ESCO1(4), NAT6(1) 9864118 11 11 11 1 2 0 2 4 3 0 0.193 0.649 1.000 164 BCRPATHWAY B cell antigen receptors (BCRs) activate tyrosine kinases and transiently increase tyrosine phosphorylation on binding to antigen. BLNK, BTK, CALM1, CALM2, CALM3, CD79A, CD79B, ELK1, FOS, GRB2, HRAS, JUN, LYN, MAP2K1, MAP3K1, MAPK14, MAPK3, MAPK8, NFATC1, NFATC2, NFATC3, NFATC4, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, RAC1, RAF1, SHC1, SOS1, SYK, SYT1, VAV1 34 BTK(1), GRB2(1), HRAS(3), NFATC1(1), NFATC2(1), PLCG1(1), PPP3CA(1), PPP3CC(1), PRKCA(2), RAC1(1), RAF1(1), SHC1(2), SOS1(1), SYK(2), SYT1(1), VAV1(3) 14888175 23 21 23 3 11 1 4 7 0 0 0.0456 0.650 1.000 165 SPPAPATHWAY Thrombin cleaves protease-activated receptors PAR1 and PAR4 to induce calcium influx and activate platelet aggregation, a process inhibited by aspirin. F2, F2R, F2RL3, GNAI1, GNB1, GNGT1, HRAS, ITGA1, ITGB1, MAP2K1, MAPK1, MAPK3, PLA2G4A, PLCB1, PRKCA, PRKCB1, PTGS1, PTK2, RAF1, SRC, SYK, TBXAS1 21 F2(1), GNAI1(1), GNB1(1), GNGT1(1), HRAS(3), MAPK1(1), PLA2G4A(2), PLCB1(2), PRKCA(2), PTGS1(1), PTK2(2), RAF1(1), SYK(2) 9511616 20 16 20 4 10 3 3 4 0 0 0.128 0.656 1.000 166 SIG_CD40PATHWAYMAP Genes related to CD40 signaling DUSP1, GORASP1, IKBKG, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MAPKAPK5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PIK3CA, PIK3CD, PIK3R1, SYT1, TNFRSF5, TRAF2, TRAF3, TRAF5, TRAF6 32 DUSP1(1), MAP2K4(1), MAP2K7(2), MAPK1(1), MAPK8IP3(2), MAPKAPK5(1), NFKBIL1(1), PIK3CA(10), PIK3R1(1), SYT1(1), TRAF2(3), TRAF5(1) 13241627 25 20 25 3 8 3 2 8 4 0 0.0746 0.658 1.000 167 BLYMPHOCYTEPATHWAY B cells express the major histocompatibility complex (class II MHC), immunoglobulins, adhesion proteins, and other factors on their cell surface. CD80, CR1, CR2, FCGR2B, HLA-DRA, HLA-DRB1, ICAM1, ITGAL, ITGB2, PTPRC, TNFRSF5 10 HLA-DRA(1), ITGAL(3), ITGB2(2), PTPRC(3) 5913029 9 8 9 2 4 1 1 3 0 0 0.326 0.658 1.000 168 ST_GAQ_PATHWAY G-alpha-q activates phospholipase C, resulting in calcium influx and increasing protein kinase C activity. ADRBK1, AKT1, AKT2, AKT3, BF, DAG1, GNAQ, IKBKG, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PDK1, PHKA2, PIK3CB, PITX2, PLD1, PLD2, PLD3, VN1R1 26 AKT1(1), AKT2(1), DAG1(1), ITPKB(2), ITPR1(2), ITPR2(3), ITPR3(1), NFKBIL1(1), PDK1(1), PHKA2(1), PIK3CB(1), PITX2(1), PLD1(2), VN1R1(2) 17571316 20 19 20 1 4 5 2 2 7 0 0.0158 0.664 1.000 169 IL3PATHWAY IL-3 promotes proliferation and differentiation of hematopoietic cells via a heterodimeric receptor that activates the Stat5 and MAP kinase pathways. CSF2RB, FOS, GRB2, HRAS, IL3, IL3RA, JAK2, MAP2K1, MAPK3, PTPN6, RAF1, SHC1, SOS1, STAT5A, STAT5B 15 GRB2(1), HRAS(3), IL3RA(1), RAF1(1), SHC1(2), SOS1(1), STAT5B(1) 6895099 10 10 10 3 5 2 3 0 0 0 0.405 0.665 1.000 170 SLRPPATHWAY Small leucine-rich proteoglycans (SLRPs) interact with and reorganize collagen fibers in the extracellular matrix. BGN, DCN, DSPG3, FMOD, KERA, LUM 5 KERA(1) 1401885 1 1 1 1 0 0 0 1 0 0 0.950 0.675 1.000 171 INOSITOL_METABOLISM ALDH6A1, ALDOA, ALDOB, ALDOC, TPI1 5 ALDOC(1) 1524260 1 1 1 1 0 0 0 1 0 0 0.947 0.675 1.000 172 HSA00030_PENTOSE_PHOSPHATE_PATHWAY Genes involved in pentose phosphate pathway ALDOA, ALDOB, ALDOC, DERA, FBP1, FBP2, G6PD, GPI, H6PD, PFKL, PFKM, PFKP, PGD, PGLS, PGM1, PGM3, PRPS1, PRPS1L1, PRPS2, RBKS, RPE, RPIA, TALDO1, TKT, TKTL1, TKTL2 26 ALDOC(1), H6PD(2), PFKL(1), PFKM(1), PFKP(1), PGM1(1), PGM3(1), PRPS1L1(2), RBKS(2), TKT(1) 9512270 13 13 13 2 3 0 3 4 3 0 0.305 0.675 1.000 173 LIMONENE_AND_PINENE_DEGRADATION ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, ECHS1, EHHADH, HADHA, SDS 12 ALDH1A1(1), ALDH1A2(3), ALDH1A3(1), ALDH3A1(1), EHHADH(2) 4752331 8 8 7 3 2 1 1 4 0 0 0.657 0.676 1.000 174 GANGLIOSIDE_BIOSYNTHESIS B3GALT4, GALGT, SIAT4A, SIAT4B, SIAT7B, SIAT7D, SIAT9, ST3GAL1, ST3GAL2, ST3GAL4, ST3GAL5, ST6GALNAC2, ST6GALNAC4, ST8SIA1 8 ST3GAL1(2), ST6GALNAC2(1), ST8SIA1(1) 2204203 4 4 4 2 2 1 0 0 1 0 0.749 0.677 1.000 175 ERBB3PATHWAY Neuregulins bind to the receptor tyrosine kinases ErbB3 and ErbB4, surface-localized receptors whose overexpression induces tumor formation. EGF, EGFR, ERBB3, NRG1, UBE2D1 5 EGFR(2), ERBB3(2), NRG1(2) 4009657 6 6 6 2 0 1 0 3 2 0 0.691 0.679 1.000 176 SYNTHESIS_AND_DEGRADATION_OF_KETONE_BODIES ACAT1, ACAT2, BDH, HMGCL, OXCT1 4 ACAT1(1) 1314575 1 1 1 0 0 0 0 1 0 0 0.819 0.681 1.000 177 HSA00591_LINOLEIC_ACID_METABOLISM Genes involved in linoleic acid metabolism AKR1B10, ALOX15, ALOX5, CYP1A2, CYP2C18, CYP2C19, CYP2C8, CYP2C9, CYP2E1, CYP2J2, CYP3A4, CYP3A43, CYP3A5, CYP3A7, HSD3B7, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, RDH11, RDH12, RDH13, RDH14 31 ALOX15(1), CYP1A2(1), CYP2C18(1), CYP2C8(3), CYP3A43(1), CYP3A7(1), PLA2G12B(1), PLA2G2A(1), PLA2G4A(2), PLA2G6(1), RDH12(1) 9330268 14 11 14 2 4 0 2 6 2 0 0.227 0.682 1.000 178 HSA00632_BENZOATE_DEGRADATION_VIA_COA_LIGATION Genes involved in benzoate degradation via CoA ligation ACAT1, ACAT2, ACOT11, ACYP1, ACYP2, ARD1A, CARKL, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ECHS1, EHHADH, ESCO1, ESCO2, FN3K, GCDH, HADHA, ITGB1BP3, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1, YOD1 24 ACAT1(1), DHRS1(1), DHRS7(1), DHRSX(1), EHHADH(2), ESCO1(4), NAT6(1) 10111081 11 11 11 0 2 1 0 4 4 0 0.0570 0.684 1.000 179 ST_IL_13_PATHWAY Like IL-4, IL-13 is produced by Th2 cells on activation of the T cell antigen receptor, and by mast and basophil cells on activation of the IgE receptor. IL13, IL13RA1, IL13RA2, IL4R, JAK1, JAK2, TYK2 7 IL13RA1(1), IL4R(2), JAK1(3), TYK2(1) 4093255 7 6 7 2 0 1 1 2 3 0 0.593 0.686 1.000 180 ST_INTERLEUKIN_13_PATHWAY IL-13 is produced by Th2 cells on activation of the T cell antigen receptor, and by mast and basophil cells on activation of the IgE receptor. IL13, IL13RA1, IL13RA2, IL4R, JAK1, JAK2, TYK2 7 IL13RA1(1), IL4R(2), JAK1(3), TYK2(1) 4093255 7 6 7 2 0 1 1 2 3 0 0.593 0.686 1.000 181 TELPATHWAY Telomerase is a ribonucleotide protein that adds telomeric repeats to the 3' ends of chromosomes. AKT1, BCL2, EGFR, G22P1, HSPCA, IGF1R, KRAS2, MYC, POLR2A, PPP2CA, PRKCA, RB1, TEP1, TERF1, TERT, TNKS, TP53, XRCC5 14 AKT1(1), EGFR(2), IGF1R(1), POLR2A(2), PRKCA(2), RB1(2), TEP1(3), TNKS(4) 10694987 17 14 17 2 4 3 3 5 1 1 0.0723 0.687 1.000 182 ACETYLCHOLINE_SYNTHESIS ACHE, CHAT, CHKA, PCYT1A, PDHA1, PDHA2, PEMT, SLC18A3 8 ACHE(1), CHAT(2), PDHA2(2) 2741704 5 5 5 2 2 0 0 1 2 0 0.582 0.698 1.000 183 HSA00900_TERPENOID_BIOSYNTHESIS Genes involved in terpenoid biosynthesis FDFT1, FDPS, GGPS1, IDI1, IDI2, SQLE 6 SQLE(1) 1652230 1 1 1 1 1 0 0 0 0 0 0.887 0.698 1.000 184 IRINOTECAN_PATHWAY_PHARMGKB ABCC1, ABCC2, ABCG2, BCHE, CES1, CES2, CES4, CYP3A4, CYP3A5, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6 17 ABCG2(1), BCHE(1), CES1(1), UGT1A4(1), UGT1A7(1), UGT1A8(2), UGT1A9(1) 8875058 8 8 8 0 2 0 1 2 3 0 0.181 0.699 1.000 185 N_GLYCAN_DEGRADATION AGA, FLJ21865, FUCA1, FUCA2, GLB1, HEXA, HEXB, LCT, MAN2C1, MANBA, NEU1, NEU2, NEU3, NEU4 13 AGA(2), FUCA2(1), HEXB(1), LCT(3), MAN2C1(1), NEU1(1), NEU4(1) 6499946 10 8 10 2 4 1 1 1 3 0 0.384 0.701 1.000 186 LDLPATHWAY Low density lipoproteins (LDL) are present in blood plasma, contain cholesterol and triglycerides, and contribute to atherogenic plaque formation. ACAT1, CCL2, CSF1, IL6, LDLR, LPL 6 ACAT1(1), IL6(1), LDLR(1) 2074659 3 3 3 2 1 1 0 1 0 0 0.847 0.705 1.000 187 HSP27PATHWAY Hsp27 oligomers have molecular chaperone activity and protect heat-stressed cells against apoptosis. ACTA1, APAF1, BCL2, CASP3, CASP9, CYCS, DAXX, FAS, FASLG, HSPB1, HSPB2, IL1A, MAPKAPK2, MAPKAPK3, TNF, TNFRSF6 15 APAF1(1), DAXX(1), FAS(1), FASLG(1), MAPKAPK3(1), TNF(1) 4423048 6 6 6 2 1 1 1 1 2 0 0.778 0.707 1.000 188 ALKALOID_BIOSYNTHESIS_II ABP1, AOC2, AOC3, CES1, ESD 5 AOC2(1), CES1(1) 2347608 2 2 2 0 0 0 0 2 0 0 0.668 0.717 1.000 189 TNFR2PATHWAY Tumor necrosis factor beta, produced by activated lymphocytes, binds to its receptor TNFR2 to induce activation in immune cells and apoptosis in many other cells. CHUK, DUSP1, IKBKAP, IKBKB, IKBKG, LTA, MAP3K1, MAP3K14, NFKB1, NFKBIA, RELA, RIPK1, TANK, TNFAIP3, TNFRSF1B, TRAF1, TRAF2, TRAF3 17 DUSP1(1), IKBKAP(1), RELA(2), RIPK1(1), TNFAIP3(1), TRAF1(1), TRAF2(3) 8769907 10 9 10 1 3 2 2 2 1 0 0.111 0.728 1.000 190 HSA00940_PHENYLPROPANOID_BIOSYNTHESIS Genes involved in phenylpropanoid biosynthesis EPX, GBA, GBA3, LPO, MPO, PRDX6, TPO 7 EPX(1), LPO(1), TPO(1) 3277279 3 3 3 1 1 2 0 0 0 0 0.546 0.732 1.000 191 SODDPATHWAY Some members of the tumor necrosis factor receptor family have cytoplasmic death domains that promote apoptosis when active and are repressed by silencers called SODDs. BAG4, BIRC3, CASP8, FADD, RIPK1, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF2 10 RIPK1(1), TNF(1), TRAF2(3) 3289561 5 4 5 2 2 0 1 2 0 0 0.658 0.734 1.000 192 FREEPATHWAY Neutrophils release superoxide to induce lysis in invading bacteria; in neighboring endothelial cells, superoxide dismutase scavenges radicals but produces pro-apoptotic peroxides. GPX1, GSR, GSS, IL8, NFKB1, NOX1, RELA, SOD1, TNF, XDH 10 RELA(2), TNF(1) 3859707 3 3 3 0 1 1 1 0 0 0 0.307 0.735 1.000 193 HSA00780_BIOTIN_METABOLISM Genes involved in biotin metabolism BTD, HLCS, SPCS1, SPCS3 4 HLCS(1) 1206001 1 1 1 1 0 1 0 0 0 0 0.891 0.737 1.000 194 HSA04710_CIRCADIAN_RHYTHM Genes involved in circadian rhythm ARNTL, BHLHB2, BHLHB3, CLOCK, CRY1, CRY2, CSNK1D, CSNK1E, NPAS2, NR1D1, PER1, PER2, PER3 11 CRY2(2), CSNK1E(1), NPAS2(1), PER1(1), PER2(1), PER3(2) 6670747 8 7 8 1 1 1 1 4 1 0 0.322 0.737 1.000 195 HEME_BIOSYNTHESIS ALAD, ALAS1, ALAS2, CPOX, FECH, HMBS, PPOX, UROD, UROS 9 CPOX(1), HMBS(1) 2940471 2 2 2 0 1 0 0 1 0 0 0.612 0.744 1.000 196 GHPATHWAY Growth hormone receptors dimerize on ligand binding and activate the JAK2 protein kinase. GH1, GHR, GRB2, HRAS, INS, INSR, IRS1, JAK2, MAP2K1, MAPK1, MAPK3, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, PTPN6, RAF1, RPS6KA1, SHC1, SLC2A4, SOCS1, SOS1, SRF, STAT5A, STAT5B, TCF1 25 GHR(1), GRB2(1), HRAS(3), IRS1(2), MAPK1(1), PIK3CA(10), PIK3R1(1), PLCG1(1), PRKCA(2), RAF1(1), RPS6KA1(1), SHC1(2), SOS1(1), STAT5B(1) 12905387 28 24 28 5 11 5 4 7 1 0 0.0995 0.744 1.000 197 METHIONINE_METABOLISM AHCY, BHMT, CBS, CTH, DNMT1, DNMT2, DNMT3A, DNMT3B, MARS, MARS2, MAT1A, MAT2B, MTR 12 AHCY(1), CBS(1), CTH(1), DNMT1(2), DNMT3A(2), DNMT3B(1), MARS2(1), MAT1A(1) 6799277 10 10 10 3 2 2 2 0 4 0 0.493 0.745 1.000 198 SIG_PIP3_SIGNALING_IN_B_LYMPHOCYTES Genes related to PIP3 signaling in B lymphocytes AKT1, AKT2, AKT3, BCR, BTK, CD19, CDKN2A, DAPP1, FLOT1, FLOT2, FOXO3A, GAB1, ITPR1, ITPR2, ITPR3, LYN, NR0B2, P101-PI3K, PDK1, PHF11, PIK3CA, PITX2, PLCG2, PPP1R13B, PREX1, PSCD3, PTEN, PTPRC, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SAG, SYK, TEC, VAV1 32 AKT1(1), AKT2(1), BCR(1), BTK(1), CDKN2A(1), ITPR1(2), ITPR2(3), ITPR3(1), PDK1(1), PIK3CA(10), PITX2(1), PLCG2(1), PPP1R13B(1), PTPRC(3), RPS6KA1(1), SAG(1), SYK(2), VAV1(3) 21327523 35 33 35 6 7 6 5 9 8 0 0.0714 0.749 1.000 199 1_2_DICHLOROETHANE_DEGRADATION ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1 8 ALDH1A1(1), ALDH1A2(3), ALDH1A3(1), ALDH3A1(1) 3125531 6 6 5 3 2 0 1 3 0 0 0.801 0.750 1.000 200 ASCORBATE_AND_ALDARATE_METABOLISM ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1 8 ALDH1A1(1), ALDH1A2(3), ALDH1A3(1), ALDH3A1(1) 3125531 6 6 5 3 2 0 1 3 0 0 0.801 0.750 1.000 201 ST_G_ALPHA_S_PATHWAY The G-alpha-s protein activates adenylyl cyclases, which catalyze cAMP formation. ASAH1, BF, BFAR, BRAF, CAMP, CREB1, CREB3, CREB5, EPAC, GAS, GRF2, MAPK1, RAF1, SNX13, SRC, TERF2IP 11 ASAH1(1), CREB3(1), MAPK1(1), RAF1(1), SNX13(2), TERF2IP(1) 3764020 7 7 7 3 1 1 1 1 3 0 0.903 0.751 1.000 202 HSA00460_CYANOAMINO_ACID_METABOLISM Genes involved in cyanoamino acid metabolism ASRGL1, GBA, GBA3, GGT1, GGTL3, GGTL4, SHMT1, SHMT2 6 SHMT1(1), SHMT2(1) 2159645 2 2 2 0 1 1 0 0 0 0 0.407 0.755 1.000 203 CACAMPATHWAY Calcium functions as a second messenger activating the calcium/calmodulin-dependent kinases, which phosphorylate targets such as CREB. CALM1, CALM2, CALM3, CAMK1, CAMK1G, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CAMKK1, CAMKK2, CREB1, SYT1 14 CAMK1(2), CAMK1G(1), CAMK2A(1), CAMK2D(1), CAMK4(2), SYT1(1) 4527827 8 8 8 3 4 0 0 3 1 0 0.738 0.762 1.000 204 HSA00750_VITAMIN_B6_METABOLISM Genes involved in vitamin B6 metabolism AOX1, PDXK, PDXP, PNPO, PSAT1 5 AOX1(1) 1892334 1 1 1 0 0 0 0 0 1 0 0.836 0.763 1.000 205 IGF1MTORPATHWAY Growth factor IGF-1 activates AKT, Gsk3-beta, and mTOR to promote muscle hypertrophy. AKT1, EIF2B5, EIF2S1, EIF2S2, EIF2S3, EIF4E, EIF4EBP1, FRAP1, GSK3B, IGF1, IGF1R, INPPL1, PDK2, PDPK1, PIK3CA, PIK3R1, PPP2CA, PTEN, RPS6, RPS6KB1 18 AKT1(1), GSK3B(1), IGF1R(1), PDPK1(1), PIK3CA(10), PIK3R1(1) 7363935 15 14 15 4 3 4 3 4 1 0 0.375 0.764 1.000 206 SA_DIACYLGLYCEROL_SIGNALING DAG (diacylglycerol) signaling activity ESR1, ESR2, ITPKA, PDE1A, PDE1B, PLCB1, PLCB2, PRL, TRH, VIP 10 ESR1(1), PDE1B(1), PLCB1(2) 4358593 4 4 4 1 1 1 1 0 1 0 0.451 0.764 1.000 207 HSA03060_PROTEIN_EXPORT Genes involved in protein export OXA1L, SEC61A2, SRP19, SRP54, SRP68, SRP72, SRP9, SRPR 8 SEC61A2(1), SRP54(1) 2933848 2 2 2 0 0 0 0 1 1 0 0.609 0.766 1.000 208 PORPHYRIN_AND_CHLOROPHYLL_METABOLISM ALAD, BLVRA, BLVRB, CP, CPOX, EPRS, FECH, GUSB, HCCS, HMBS, HMOX1, HMOX2, PPOX, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4, UROD, UROS 26 BLVRB(1), CP(2), CPOX(1), EPRS(2), HMBS(1), HMOX2(1), UGT1A4(1), UGT1A7(1), UGT1A8(2), UGT1A9(1), UGT2B15(1) 10684208 14 14 14 3 6 0 1 5 2 0 0.411 0.766 1.000 209 MITOCHONDRIAL_FATTY_ACID_BETAOXIDATION ACADL, ACADM, ACADS, ACADVL, ACSL1, ACSL3, ACSL4, CPT1A, CPT2, DCI, EHHADH, HADHA, HADHSC, MGC5139, PECR, SCP2, SLC25A20 15 ACADS(2), ACSL1(1), EHHADH(2), SLC25A20(1) 6565568 6 6 5 0 2 1 0 2 1 0 0.206 0.767 1.000 210 GLUCOCORTICOID_MINERALOCORTICOID_METABOLISM CPN2, CYP11A1, CYP11B2, CYP17A1, HSD11B1, HSD11B2, HSD3B1, HSD3B2 8 CYP11B2(1), HSD11B1(1) 2694122 2 2 2 0 0 0 0 0 2 0 0.447 0.767 1.000 211 VALINE_LEUCINE_AND_ISOLEUCINE_DEGRADATION ACAA1, ACAA2, ACADL, ACADM, ACADS, ACADSB, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH9A1, AOX1, BCAT1, BCKDHA, BCKDHB, ECHS1, EHHADH, HADHA, HADHB, HIBADH, HMGCL, IVD, MCCC1, MCCC2, MCEE, MUT, OXCT1, PCCA, PCCB, SDS 36 ACAA1(2), ACAA2(1), ACADS(2), ACADSB(2), ACAT1(1), ALDH1A1(1), ALDH1A2(3), ALDH1A3(1), ALDH3A1(1), AOX1(1), BCAT1(1), BCKDHA(1), EHHADH(2), HADHB(1), IVD(1), MUT(1) 14032119 22 20 20 4 7 2 3 7 3 0 0.145 0.770 1.000 212 ACE_INHIBITOR_PATHWAY_PHARMGKB ACE, AGT, AGTR1, AGTR2, BDKRB2, KNG1, NOS3, REN 8 ACE(2), AGTR1(2), NOS3(1) 3898716 5 4 5 1 2 0 0 2 1 0 0.631 0.773 1.000 213 HSA00072_SYNTHESIS_AND_DEGRADATION_OF_KETONE_BODIES Genes involved in synthesis and degradation of ketone bodies ACAT1, ACAT2, BDH1, BDH2, HMGCL, HMGCS1, HMGCS2, OXCT1, OXCT2 9 ACAT1(1), HMGCS2(1) 2799481 2 2 2 0 1 0 0 1 0 0 0.572 0.780 1.000 214 GLYCOSAMINOGLYCAN_DEGRADATION ARSB, GALNS, GLB1, GNS, GUSB, HEXA, HEXB, IDS, IDUA, LCT, NAGLU 11 ARSB(1), GALNS(2), HEXB(1), LCT(3) 5622498 7 6 7 1 3 1 0 2 1 0 0.325 0.784 1.000 215 TSP1PATHWAY Thrombospondin-1 (TSP-1) inhibits angiogenesis by inducing caspase-dependent apoptosis in microvascular endothelial cells. CASP3, CD36, FOS, FYN, JUN, MAPK14, THBS1 7 THBS1(2) 2882717 2 2 2 0 1 0 1 0 0 0 0.466 0.785 1.000 216 TH1TH2PATHWAY Helper T subtype Th1 produces pro-inflammatory cytokines that stimulate phagocytosis, while Th2 cells promote antibody production and activate eosinophils. CD28, CD86, HLA-DRA, HLA-DRB1, IFNG, IFNGR1, IFNGR2, IL12A, IL12B, IL12RB1, IL12RB2, IL18, IL18R1, IL2, IL2RA, IL4, IL4R, TNFRSF5, TNFSF5 17 HLA-DRA(1), IL12A(1), IL12RB2(1), IL4(1), IL4R(2) 4936971 6 5 6 2 2 0 0 1 3 0 0.657 0.788 1.000 217 NICOTINATE_AND_NICOTINAMIDE_METABOLISM AOX1, CD38, ENPP1, ENPP3, NADSYN1, NMNAT1, NMNAT2, NNMT, NNT, NP, NT5C, NT5E, NT5M, QPRT 13 AOX1(1), CD38(1), ENPP1(2), ENPP3(1), NADSYN1(1), NNMT(1), NNT(2), NT5M(1) 5677473 10 10 10 4 3 2 1 1 3 0 0.561 0.794 1.000 218 SKP2E2FPATHWAY E2F-1, a transcription factor that promotes the G1/S transition, is repressed by Rb and activated by cdk2/cyclin E. CCNA1, CCNE1, CDC34, CDK2, CUL1, E2F1, RB1, SKP1A, SKP2, TFDP1 9 CCNA1(1), RB1(2), TFDP1(1) 3324868 4 4 4 2 0 1 2 0 0 1 0.697 0.795 1.000 219 RNAPATHWAY dsRNA-activated protein kinase phosphorylates elF2a, which generally inhibits translation, and activates NF-kB to provoke inflammation. CHUK, DNAJC3, EIF2S1, EIF2S2, MAP3K14, NFKB1, NFKBIA, PRKR, RELA, TP53 8 RELA(2) 3504581 2 2 2 0 0 1 1 0 0 0 0.440 0.796 1.000 220 MITOCHONDRIAPATHWAY Pro-apoptotic signaling induces mitochondria to release cytochrome c, which stimulates Apaf-1 to activate caspase 9. APAF1, BAK1, BAX, BCL2, BCL2L1, BID, BIK, BIRC2, BIRC3, BIRC4, CASP3, CASP6, CASP7, CASP8, CASP9, CYCS, DFFA, DFFB, DIABLO, ENDOG, PDCD8 19 APAF1(1), BIK(1), BIRC2(1), DFFA(1) 5304455 4 4 4 0 0 2 0 1 1 0 0.352 0.804 1.000 221 MSPPATHWAY Macrophage stimulating protein is synthesized as pro-MSP by the liver and, on proteolysis, binds to monocyte receptor kinase RON to induce macrophage development. CCL2, CSF1, IL1B, MST1, MST1R, TNF 6 MST1(2), MST1R(2), TNF(1) 2563789 5 4 5 2 3 1 0 0 1 0 0.707 0.808 1.000 222 ST_WNT_BETA_CATENIN_PATHWAY Beta-catenin is degraded in the absence of Wnt signaling; when extracellular Wnt binds Frizzled receptors, beta-catenin accumulates in the nucleus and may promote cell survival. AKT1, AKT2, AKT3, ANKRD6, APC, AXIN1, AXIN2, C22orf2, CER1, CSNK1A1, CTNNB1, DACT1, DKK1, DKK2, DKK3, DKK4, DVL1, FRAT1, FSTL1, GSK3A, GSK3B, IDAX, LAMR1, LRP1, MVP, NKD1, NKD2, PIN1, PSEN1, PTPRA, SENP2, SFRP1, TSHB, WIF1 29 AKT1(1), AKT2(1), ANKRD6(1), APC(2), AXIN2(2), DACT1(3), DKK2(2), GSK3A(2), GSK3B(1), LRP1(3), NKD2(1), PTPRA(3), WIF1(2) 15185362 24 19 24 4 7 5 2 6 4 0 0.0794 0.812 1.000 223 KREBPATHWAY The Krebs (citric acid) cycle takes place in mitochondria, where it extracts energy in the form of electron carriers NADH and FADH2, which drive the electron transport chain. ACO2, CS, FH, IDH2, MDH1, OGDH, SDHA, SUCLA2 8 ACO2(1), FH(1), SDHA(1) 3659568 3 3 3 0 0 0 1 2 0 0 0.496 0.812 1.000 224 G1PATHWAY CDK4/6-cyclin D and CDK2-cyclin E phosphorylate Rb, which allows the transcription of genes needed for the G1/S cell cycle transition. ABL1, ATM, ATR, CCNA1, CCND1, CCNE1, CDC2, CDC25A, CDK2, CDK4, CDK6, CDKN1A, CDKN1B, CDKN2A, CDKN2B, DHFR, E2F1, GSK3B, HDAC1, MADH3, MADH4, RB1, SKP2, TFDP1, TGFB1, TGFB2, TGFB3, TP53 23 ABL1(4), CCNA1(1), CDC25A(1), CDKN1A(2), CDKN1B(4), CDKN2A(1), DHFR(1), GSK3B(1), RB1(2), TFDP1(1), TGFB1(1), TGFB2(1) 9049782 20 15 20 6 4 1 4 1 9 1 0.687 0.815 1.000 225 RABPATHWAY Rab family GTPases regulate vesicle transport, endocytosis and exocytosis, and vesicle docking via interactions with the rabphilins. ACTA1, MEL, RAB11A, RAB1A, RAB2, RAB27A, RAB3A, RAB4A, RAB5A, RAB6A, RAB7, RAB9A 9 RAB11A(1) 1651568 1 1 1 2 0 0 0 0 1 0 0.980 0.816 1.000 226 LYMPHOCYTEPATHWAY B and T cell lymphocytes interact with other cells via transmembrane adhesion proteins such as CD44, which interacts with endothelial cells. CD44, ICAM1, ITGA4, ITGAL, ITGB1, ITGB2, PECAM1, SELE, SELL 9 ITGAL(3), ITGB2(2), SELE(1) 4714039 6 5 6 2 3 0 1 2 0 0 0.568 0.817 1.000 227 ARGININECPATHWAY Related catabolic pathways process arginine, histidine, glutamine, and proline through glutamate to alpha-ketoglutamate, which feeds into the citric acid cycle. ALDH4A1, ARG1, GLS, GLUD1, OAT, PRODH 6 ALDH4A1(1) 2172276 1 1 1 0 0 0 0 0 1 0 1.000 0.824 1.000 228 RANKLPATHWAY RANK is a TNF-type receptor that promotes osteoclast differentiation and consequent bone resorbtion on binding RANK ligand produced by osteoblasts. FOS, FOSL1, FOSL2, IFNAR1, IFNAR2, IFNB1, ISGF3G, MAPK8, NFKB1, PRKR, RELA, TNFRSF11A, TNFSF11, TRAF6 12 RELA(2), TNFSF11(1) 4333042 3 3 3 0 0 1 1 1 0 0 0.370 0.825 1.000 229 ST_INTERFERON_GAMMA_PATHWAY The interferon gamma pathway resembles the JAK-STAT pathway and activates STAT transcription factors. CISH, IFNG, IFNGR1, JAK1, JAK2, PLA2G2A, PTPRU, REG1A, STAT1, STATIP1 9 JAK1(3), PLA2G2A(1), PTPRU(2), STAT1(1) 4471790 7 6 7 2 1 1 0 4 1 0 0.666 0.827 1.000 230 SALMONELLAPATHWAY Salmonella induces membrane ruffling in infected cells via bacterial proteins including SipA, SipC, and SopE, which alter actin structure. ACTA1, ACTR2, ACTR3, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, CDC42, RAC1, WASF1, WASL 12 ACTR3(1), RAC1(1) 3154834 2 2 2 0 0 0 1 1 0 0 0.560 0.827 1.000 231 ACE2PATHWAY Angiotensin-converting enzyme 2 (ACE2) digests the blood-pressure regulator angiotensin II (AGT) ultimately to the vasodilator AGT1-7. ACE2, AGT, AGTR1, AGTR2, CMA1, COL4A1, COL4A2, COL4A3, COL4A4, COL4A5, COL4A6, REN 12 AGTR1(2), CMA1(1), COL4A1(1), COL4A2(2), COL4A3(1), COL4A4(1), COL4A5(1) 9784459 9 8 9 1 3 2 1 2 1 0 0.171 0.831 1.000 232 TCRAPATHWAY The kinases Lck and Fyn phosphorylate and activate the T cell receptor, which recognizes antigen-bound MHCII and leads to T cell activation. CD3D, CD3E, CD3G, CD3Z, CD4, FYN, HLA-DRA, HLA-DRB1, LCK, PTPRC, TRA@, TRB@, ZAP70 10 HLA-DRA(1), PTPRC(3), ZAP70(2) 3519574 6 6 6 3 3 1 1 1 0 0 0.684 0.831 1.000 233 IL17PATHWAY Activated T cells secrete IL-17, which stimulates fibroblasts and other cells to secrete inflammatory and hematopoietic cytokines. CD2, CD34, CD3D, CD3E, CD3G, CD3Z, CD4, CD58, CD8A, CSF3, IL17, IL3, IL6, IL8, KITLG, TRA@, TRB@ 13 CD8A(1), IL6(1) 2410205 2 2 2 3 0 1 0 0 1 0 0.942 0.834 1.000 234 CASPASEPATHWAY Caspases are cysteine proteases active in apoptosis; caspase-8 and 9 cleave and activate other caspases, while 3, 6, and 7 cleave cellular targets. ADPRT, APAF1, ARHGDIB, BIRC2, BIRC3, BIRC4, CASP1, CASP10, CASP2, CASP3, CASP4, CASP6, CASP7, CASP8, CASP9, CYCS, DFFA, DFFB, GZMB, LMNA, LMNB1, LMNB2, PRF1 21 APAF1(1), ARHGDIB(1), BIRC2(1), CASP1(2), DFFA(1), LMNA(2), PRF1(1) 7546343 9 9 9 2 3 2 0 2 2 0 0.490 0.834 1.000 235 IFNAPATHWAY Interferon alpha, active in the immune response, binds to the IFN receptor and activates Jak1 and Tyk2, which phosphorylate Stat1 and Stat2. IFNA1, IFNAR1, IFNAR2, IFNB1, ISGF3G, JAK1, STAT1, STAT2, TYK2 8 JAK1(3), STAT1(1), TYK2(1) 4231346 5 4 5 2 0 1 0 2 2 0 0.781 0.834 1.000 236 STAT3PATHWAY The STAT transcription factors are phosphorylated and activated by JAK kinases in response to cytokine signaling. FRAP1, JAK1, JAK2, JAK3, MAPK1, MAPK3, STAT3, TYK2 7 JAK1(3), MAPK1(1), STAT3(5), TYK2(1) 4613926 10 9 10 5 1 2 1 3 3 0 0.840 0.837 1.000 237 TCRPATHWAY T cell receptors bind to foreign peptides presented by MHC molecules and induce T cell activation. CALM1, CALM2, CALM3, CD3D, CD3E, CD3G, CD3Z, ELK1, FOS, FYN, GRB2, HRAS, JUN, LAT, LCK, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKBIA, PIK3CA, PIK3R1, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, PTPN7, RAC1, RAF1, RASA1, RELA, SHC1, SOS1, SYT1, TRA@, TRB@, VAV1, ZAP70 42 GRB2(1), HRAS(3), MAP2K4(1), NFATC1(1), NFATC2(1), PIK3CA(10), PIK3R1(1), PLCG1(1), PPP3CA(1), PPP3CC(1), PRKCA(2), RAC1(1), RAF1(1), RELA(2), SHC1(2), SOS1(1), SYT1(1), VAV1(3), ZAP70(2) 18632708 36 29 36 7 14 4 7 11 0 0 0.0704 0.844 1.000 238 EPONFKBPATHWAY The cytokine erythropoietin (Epo) prevents stress-induced neuronal apoptosis by stimulating anti-apoptotic pathways through JAK2 kinase and NF-kB. ARNT, CDKN1A, EPO, EPOR, GRIN1, HIF1A, JAK2, NFKB1, NFKBIA, RELA, SOD2 11 ARNT(2), CDKN1A(2), GRIN1(1), RELA(2), SOD2(1) 4963536 8 6 8 2 4 1 1 0 2 0 0.553 0.844 1.000 239 HDACPATHWAY Myocyte enhancer factor MEF2 activates transcription of genes required for muscle cell differentiation and is inhibited by histone deacetylases. AKT1, AVP, CABIN1, CALM1, CALM2, CALM3, CAMK1, CAMK1G, HDAC5, IGF1, IGF1R, INS, INSR, MAP2K6, MAPK14, MAPK7, MEF2A, MEF2B, MEF2C, MEF2D, MYOD1, NFATC1, NFATC2, PIK3CA, PIK3R1, PPP3CA, PPP3CB, PPP3CC, SYT1, YWHAH 30 AKT1(1), CABIN1(1), CAMK1(2), CAMK1G(1), HDAC5(2), IGF1R(1), MEF2A(1), MEF2C(2), MEF2D(1), NFATC1(1), NFATC2(1), PIK3CA(10), PIK3R1(1), PPP3CA(1), PPP3CC(1), SYT1(1), YWHAH(1) 13622972 29 22 29 5 10 4 5 9 1 0 0.0688 0.845 1.000 240 HSA00624_1_AND_2_METHYLNAPHTHALENE_DEGRADATION Genes involved in 1- and 2-methylnaphthalene degradation ACAD8, ACAD9, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ARD1A, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ESCO1, ESCO2, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1 22 ADH1B(1), ADH4(1), ADH6(1), DHRS1(1), DHRS7(1), DHRSX(1), ESCO1(4), NAT6(1) 9727352 11 9 11 0 3 0 1 3 4 0 0.0484 0.846 1.000 241 HSA00590_ARACHIDONIC_ACID_METABOLISM Genes involved in arachidonic acid metabolism AKR1C3, ALOX12, ALOX12B, ALOX15, ALOX15B, ALOX5, CBR1, CBR3, CYP2B6, CYP2C18, CYP2C19, CYP2C8, CYP2C9, CYP2E1, CYP2J2, CYP2U1, CYP4A11, CYP4A22, CYP4F2, CYP4F3, DHRS4, EPHX2, GGT1, GGTL3, GGTL4, GPX1, GPX2, GPX3, GPX4, GPX5, GPX6, GPX7, LTA4H, LTC4S, PGDS, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PTGDS, PTGES, PTGES2, PTGIS, PTGS1, PTGS2, TBXAS1 51 ALOX15(1), CYP2B6(2), CYP2C18(1), CYP2C8(3), CYP4F2(1), DHRS4(1), GPX4(1), PLA2G12B(1), PLA2G2A(1), PLA2G4A(2), PLA2G6(1), PTGS1(1), PTGS2(2) 15236263 18 18 18 2 5 2 2 6 3 0 0.0811 0.849 1.000 242 ECMPATHWAY Extracellular matrix induces integrin-mediated FAK phosphorylation in epithelial cells, leading to PI3 and MAP kinase activation and actin reorganization. ARHA, ARHGAP5, DIAPH1, FYN, GSN, HRAS, ITGA1, ITGB1, MAP2K1, MAPK1, MAPK3, MYL2, MYLK, PFN1, PIK3CA, PIK3R1, PTK2, PXN, RAF1, ROCK1, SHC1, SRC, TLN1 22 DIAPH1(1), GSN(1), HRAS(3), MAPK1(1), MYLK(3), PFN1(1), PIK3CA(10), PIK3R1(1), PTK2(2), PXN(1), RAF1(1), ROCK1(5), SHC1(2), TLN1(2) 14557694 34 29 33 8 12 3 7 8 4 0 0.246 0.852 1.000 243 FMLPPATHWAY The fMLP receptor is a G-protein coupled receptor in neutrophils that recognizes formylated bacterial peptides and activates NADPH oxidase. CALM1, CALM2, CALM3, CAMK1, CAMK1G, ELK1, FPR1, GNA15, GNB1, GNGT1, HRAS, MAP2K1, MAP2K2, MAP2K3, MAP2K6, MAP3K1, MAPK1, MAPK14, MAPK3, NCF1, NCF2, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKBIA, PAK1, PIK3C2G, PLCB1, PPP3CA, PPP3CB, PPP3CC, RAC1, RAF1, RELA, SYT1 37 CAMK1(2), CAMK1G(1), FPR1(1), GNB1(1), GNGT1(1), HRAS(3), MAPK1(1), NCF1(1), NCF2(2), NFATC1(1), NFATC2(1), PLCB1(2), PPP3CA(1), PPP3CC(1), RAC1(1), RAF1(1), RELA(2), SYT1(1) 14907179 24 19 24 4 8 2 5 8 1 0 0.111 0.853 1.000 244 IONPATHWAY Activated phospholipase C hydrolyzes the lipid PIP3 into second messengers DAG, which activates protein kinase C, and IP3, which induces calcium influx into the cytoplasm. P2RY2, PLCG1, PRKCA, PRKCB1, PTK2B 4 PLCG1(1), PRKCA(2) 2613530 3 3 3 1 2 0 0 1 0 0 0.710 0.854 1.000 245 BLOOD_GROUP_GLYCOLIPID_BIOSYNTHESIS_LACTOSERIES ABO, FUT1, FUT2, FUT3, FUT5, FUT6, SIAT6, ST3GAL3 7 FUT1(1), FUT2(1), FUT3(1) 1983972 3 3 3 2 0 2 0 1 0 0 0.818 0.855 1.000 246 BLOOD_GROUP_GLYCOLIPID_BIOSYNTHESIS_NEOLACTOSERIES ABO, B3GNT1, FUT1, FUT2, FUT9, GCNT2, ST8SIA1 7 FUT1(1), FUT2(1), GCNT2(1), ST8SIA1(1) 2398187 4 4 4 4 0 2 1 0 1 0 0.952 0.857 1.000 247 NKTPATHWAY T cell differentiation into Th1 and Th2 cells occurs by differential chemokine receptor expression, which mediates tissue localization and immune response. CCL3, CCL4, CCR1, CCR2, CCR3, CCR4, CCR5, CCR7, CD28, CD4, CSF2, CXCR3, CXCR4, IFNG, IFNGR1, IFNGR2, IL12A, IL12B, IL12RB1, IL12RB2, IL18R1, IL2, IL4, IL4R, IL5, TGFB1, TGFB2, TGFB3, TNFSF5 28 CCR2(1), CCR4(1), CCR7(1), IL12A(1), IL12RB2(1), IL4(1), IL4R(2), TGFB1(1), TGFB2(1) 7774061 10 9 10 2 2 0 1 4 3 0 0.384 0.858 1.000 248 CHEMICALPATHWAY DNA damage promotes Bid cleavage, which stimulates mitochondrial cytochrome c release and consequent caspase activation, resulting in apoptosis. ADPRT, AKT1, APAF1, ATM, BAD, BAX, BCL2, BCL2L1, BID, CASP3, CASP6, CASP7, CASP9, CYCS, EIF2S1, PRKCA, PRKCB1, PTK2, PXN, STAT1, TLN1, TP53 18 AKT1(1), APAF1(1), PRKCA(2), PTK2(2), PXN(1), STAT1(1), TLN1(2) 7951287 10 8 10 0 3 3 0 3 1 0 0.0334 0.860 1.000 249 CELL2CELLPATHWAY Epithelial cell adhesion proteins such as cadherins transduce signals into the cell via catenins, which alter cell shape and motility. ACTN1, ACTN2, ACTN3, BCAR1, CSK, CTNNA1, CTNNA2, CTNNB1, PECAM1, PTK2, PXN, SRC, VCL 12 BCAR1(1), CTNNA2(4), PTK2(2), PXN(1) 6890159 8 7 8 0 4 1 0 2 1 0 0.0875 0.862 1.000 250 CELLCYCLEPATHWAY Cyclins interact with cyclin-dependent kinases to form active kinase complexes that regulate progression through the cell cycle. CCNA1, CCNB1, CCND1, CCND2, CCND3, CCNE1, CCNH, CDC2, CDC25A, CDK2, CDK4, CDK6, CDK7, CDKN1A, CDKN1B, CDKN2A, CDKN2B, CDKN2C, CDKN2D, E2F1, RB1, RBL1, TFDP1 22 CCNA1(1), CCND3(1), CDC25A(1), CDKN1A(2), CDKN1B(4), CDKN2A(1), RB1(2), TFDP1(1) 6301666 13 10 13 5 3 1 2 1 5 1 0.765 0.864 1.000 251 HSA00430_TAURINE_AND_HYPOTAURINE_METABOLISM Genes involved in taurine and hypotaurine metabolism BAAT, CDO1, CSAD, GAD1, GAD2, GGT1, GGTL3, GGTL4 6 GAD2(4) 2255572 4 4 4 4 1 1 0 1 1 0 0.938 0.866 1.000 252 NTHIPATHWAY Hemophilus influenzae infections activate NF-kB via several pathways, inducing the inflammatory response. CHUK, CREBBP, DUSP1, EP300, IKBKB, IL1B, IL8, MADH3, MADH4, MAP2K3, MAP2K6, MAP3K14, MAP3K7, MAPK11, MAPK14, MYD88, NFKB1, NFKBIA, NR3C1, RELA, TGFBR1, TGFBR2, TLR2, TNF 22 CREBBP(4), DUSP1(1), EP300(4), MAP3K7(2), RELA(2), TGFBR1(2), TNF(1) 11605899 16 14 16 3 7 1 3 3 2 0 0.238 0.867 1.000 253 CBLPATHWAY Activated EGF receptors undergo endocytosis into clathrin-coated vesicles, where they are recycled to the membrane or ubiquitinated by Cbl. CBL, CSF1R, EGF, EGFR, GRB2, MET, PDGFRA, PRKCA, PRKCB1, SH3GLB1, SH3GLB2, SH3KBP1, SRC 12 CSF1R(2), EGFR(2), GRB2(1), MET(1), PDGFRA(2), PRKCA(2), SH3GLB2(1) 7574940 11 10 11 3 5 0 3 3 0 0 0.359 0.868 1.000 254 MEF2DPATHWAY Mef2 transcription factors promote calcium-induced apoptosis in T cells and are regulated by MAP kinases and histone deacetylases. CABIN1, CALM1, CALM2, CALM3, CAPN2, CAPNS1, CAPNS2, EP300, HDAC1, HDAC2, MEF2D, NFATC1, NFATC2, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, SYT1, TRA@, TRB@ 18 CABIN1(1), CAPNS1(1), EP300(4), MEF2D(1), NFATC1(1), NFATC2(1), PPP3CA(1), PPP3CC(1), PRKCA(2), SYT1(1) 9521115 14 11 14 2 6 0 2 6 0 0 0.146 0.870 1.000 255 HSA00150_ANDROGEN_AND_ESTROGEN_METABOLISM Genes involved in androgen and estrogen metabolism AKR1C4, AKR1D1, ARSD, ARSE, CARM1, CYP11B1, CYP11B2, CYP19A1, HEMK1, HSD11B1, HSD11B2, HSD17B1, HSD17B12, HSD17B2, HSD17B3, HSD17B7, HSD17B8, HSD3B1, HSD3B2, LCMT1, LCMT2, METTL2B, METTL6, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, SRD5A1, SRD5A2, STS, SULT1E1, SULT2A1, SULT2B1, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, WBSCR22 54 AKR1C4(1), AKR1D1(1), ARSE(2), CYP11B1(1), CYP11B2(1), CYP19A1(2), HSD11B1(1), HSD17B3(1), METTL6(1), PRMT3(1), PRMT5(2), PRMT8(1), STS(1), SULT1E1(2), UGT1A4(1), UGT1A7(1), UGT1A8(2), UGT1A9(1), UGT2A1(1), UGT2A3(1), UGT2B10(2), UGT2B11(2), UGT2B15(1), UGT2B17(1), UGT2B28(2), UGT2B7(1) 19565924 34 29 34 6 7 4 4 10 9 0 0.0951 0.870 1.000 256 IL6PATHWAY IL-6 binding to its receptor activates JAK kinases and a variety of transcription factors, with effects in neuronal differentiation, bone loss, and inflammation. CEBPB, CSNK2A1, ELK1, FOS, GRB2, HRAS, IL6, IL6R, IL6ST, JAK1, JAK2, JAK3, JUN, MAP2K1, MAPK3, PTPN11, RAF1, SHC1, SOS1, SRF, STAT3 21 CEBPB(1), GRB2(1), HRAS(3), IL6(1), IL6ST(2), JAK1(3), RAF1(1), SHC1(2), SOS1(1), STAT3(5) 9307424 20 19 20 6 5 4 3 3 5 0 0.523 0.871 1.000 257 REDUCTIVE_CARBOXYLATE_CYCLE_CO2_FIXATION ACO1, ACO2, FH, IDH1, IDH2, MDH1, MDH2, SDHB, SUCLA2 8 ACO2(1), FH(1) 3133291 2 2 2 0 0 0 1 1 0 0 0.583 0.873 1.000 258 EEA1PATHWAY The FYVE-finger proteins EEA1 and HRS are localized to endosome membranes and regulate sorting and ubiquitination in the vesicle transport system. EEA1, EGF, EGFR, HGS, RAB5A, TF, TFRC 7 EEA1(2), EGFR(2), TF(1) 4997080 5 5 5 2 1 1 0 3 0 0 0.792 0.875 1.000 259 KREBS_TCA_CYCLE ACO2, CGI_48, CS, DLAT, DLD, DLST, DLST, DLSTP, FH, IDH2, IDH3A, IDH3B, IDH3G, KIAA1348, MDH1, MDH2, OGDH, PC, PDHA1, PDHA2, PDHB, PDHX, PDK1, PDK2, PDK3, PDK4, PDP2, PPM2C, SDHA, SDHA, SDHAL2, SDHB, SDHC, SDHD, SUCLA2, SUCLG1, SUCLG2, WDR50 30 ACO2(1), FH(1), IDH3A(1), PC(1), PDHA2(2), PDHX(1), PDK1(1), PDK4(1), PDP2(1), SDHA(1), SDHC(1) 11034239 12 12 12 2 1 3 1 4 3 0 0.221 0.876 1.000 260 ST_B_CELL_ANTIGEN_RECEPTOR B cell receptors bind antigens and promote B cell activation. AKT1, AKT2, AKT3, BAD, BCR, BLNK, BTK, CD19, CSK, DAG1, EPHB2, GRB2, ITPKA, ITPKB, LYN, MAP2K1, MAP2K2, MAPK1, NFAT5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PAG, PI3, PIK3CA, PIK3CD, PIK3R1, PLCG2, PPP1R13B, RAF1, SERPINA4, SHC1, SOS1, SOS2, SYK, VAV1 39 AKT1(1), AKT2(1), BCR(1), BTK(1), DAG1(1), EPHB2(3), GRB2(1), ITPKB(2), MAPK1(1), NFKBIL1(1), PIK3CA(10), PIK3R1(1), PLCG2(1), PPP1R13B(1), RAF1(1), SHC1(2), SOS1(1), SYK(2), VAV1(3) 20647755 35 32 35 7 13 5 5 8 4 0 0.106 0.879 1.000 261 INFLAMPATHWAY Interleukins and TNF serve as signals to coordinate the inflammatory response, in which macrophages recruit and activate neutrophils, fibroblasts, and T cells. CD4, CSF1, CSF2, CSF3, HLA-DRA, HLA-DRB1, IFNA1, IFNB1, IFNG, IL10, IL11, IL12A, IL12B, IL13, IL15, IL1A, IL2, IL3, IL4, IL5, IL6, IL7, IL8, LTA, PDGFA, TGFB1, TGFB2, TGFB3, TNF 29 HLA-DRA(1), IL12A(1), IL4(1), IL6(1), IL7(1), TGFB1(1), TGFB2(1), TNF(1) 5197202 8 7 8 3 3 1 1 2 1 0 0.578 0.882 1.000 262 FLUMAZENILPATHWAY Flumazenil is a benzodiazepine receptor antagonist that may induce protective preconditioning in ischemic cardiomyocytes. GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GPX1, PRKCE, SOD1 9 GABRA3(1), GABRA5(1) 3070122 2 2 2 0 1 0 0 0 1 0 0.424 0.883 1.000 263 AT1RPATHWAY Binding of angiotensin II to AT1-R activates Ca2+ signaling and the JNK pathway. AGT, AGTR1, ATF2, CALM1, CALM2, CALM3, EGFR, ELK1, GNAQ, GRB2, HRAS, JUN, MAP2K1, MAP2K2, MAP2K4, MAP3K1, MAPK1, MAPK3, MAPK8, MEF2A, MEF2B, MEF2C, MEF2D, PAK1, PRKCA, PRKCB1, PTK2, PTK2B, RAC1, RAF1, SHC1, SOS1, SRC, SYT1 33 AGTR1(2), ATF2(1), EGFR(2), GRB2(1), HRAS(3), MAP2K4(1), MAPK1(1), MEF2A(1), MEF2C(2), MEF2D(1), PRKCA(2), PTK2(2), RAC1(1), RAF1(1), SHC1(2), SOS1(1), SYT1(1) 13042766 25 21 25 5 13 2 4 6 0 0 0.105 0.883 1.000 264 GLOBOSIDE_METABOLISM A4GALT, FUT1, FUT2, FUT9, GBGT1, GLA, HEXA, HEXB, NAGA, SIAT4A, SIAT4B, ST3GAL1, ST3GAL2, ST3GAL4, ST8SIA1 13 A4GALT(2), FUT1(1), FUT2(1), HEXB(1), ST3GAL1(2), ST8SIA1(1) 3955683 8 8 8 4 4 2 0 0 2 0 0.779 0.884 1.000 265 CD40PATHWAY The CD40 receptor is a TNF-type receptor that regulates immunoglobulin expression in B cells and moderates T cell activation via T-cell expression of its ligand. CHUK, DUSP1, IKBKAP, IKBKB, IKBKG, MAP3K1, MAP3K14, NFKB1, NFKBIA, RELA, TNFAIP3, TNFRSF5, TNFSF5, TRAF3, TRAF6 12 DUSP1(1), IKBKAP(1), RELA(2), TNFAIP3(1) 7081521 5 5 5 0 1 2 1 0 1 0 0.137 0.885 1.000 266 NO2IL12PATHWAY Macrophages activate NK cells by releasing IL-12, which induces NK cytotoxic activity in coordination with NO produced by inducible nitric oxide synthase II. CCR5, CD2, CD3D, CD3E, CD3G, CD3Z, CD4, CXCR3, IFNG, IL12A, IL12B, IL12RB1, IL12RB2, JAK2, NOS2A, STAT4, TYK2 15 IL12A(1), IL12RB2(1), STAT4(3), TYK2(1) 5727151 6 6 6 3 0 0 1 1 4 0 0.820 0.885 1.000 267 ST_GA12_PATHWAY G-alpha-12 promotes cell survival and proliferation, is involved in the stress response, and activates JNK. BF, BTK, DLG4, EPHB2, F2, F2RL1, F2RL2, F2RL3, JUN, MAP2K5, MAPK1, MAPK7, MAPK8, MYEF2, PLD1, PLD2, PLD3, PTK2, RAF1, RASAL1, SRC, TEC, VAV1 22 BTK(1), EPHB2(3), F2(1), MAPK1(1), PLD1(2), PTK2(2), RAF1(1), RASAL1(2), VAV1(3) 10734193 16 14 16 3 8 1 1 4 2 0 0.250 0.886 1.000 268 D4GDIPATHWAY D4-GDI inhibits the pro-apoptotic Rho GTPases and is cleaved by caspase-3. ADPRT, APAF1, ARHGAP5, ARHGDIB, CASP1, CASP10, CASP3, CASP8, CASP9, CYCS, GZMB, JUN, PRF1 12 APAF1(1), ARHGDIB(1), CASP1(2), PRF1(1) 5021610 5 5 5 2 2 1 0 1 1 0 0.748 0.888 1.000 269 HSA04614_RENIN_ANGIOTENSIN_SYSTEM Genes involved in renin-angiotensin system ACE, ACE2, AGT, AGTR1, AGTR2, ANPEP, CMA1, CPA3, CTSA, CTSG, ENPEP, LNPEP, MAS1, MME, NLN, REN, THOP1 17 ACE(2), AGTR1(2), CMA1(1), ENPEP(1), MAS1(1), MME(2), THOP1(1) 8260739 10 8 10 2 4 1 1 4 0 0 0.358 0.889 1.000 270 THELPERPATHWAY Helper T cells coordinate the actions of B cells, macrophages, and other immune cells via surface molecules such as T cell receptor/CD3 and their characteristic marker CD4. CD2, CD28, CD3D, CD3E, CD3G, CD3Z, CD4, ICAM1, ITGAL, ITGB2, PTPRC, THY1, TRA@, TRB@ 11 ITGAL(3), ITGB2(2), PTPRC(3) 4389218 8 7 8 3 3 1 1 3 0 0 0.538 0.890 1.000 271 P35ALZHEIMERSPATHWAY p35, a neuron-specific activator of cyclin-dependent kinase 5, is cleaved to p25 in Alzheimer's disease and promotoes hyperphosphorylated tau formation and apoptosis. APP, CAPN1, CAPNS1, CAPNS2, CDK5, CDK5R1, CSNK1A1, CSNK1D, GSK3B, MAPT, PPP2CA 11 CAPNS1(1), GSK3B(1) 3623559 2 2 2 1 0 0 0 1 1 0 0.826 0.890 1.000 272 ATMPATHWAY The tumor-suppressing protein kinase ATM responds to radiation-induced DNA damage by blocking cell-cycle progression and activating DNA repair. ABL1, ATM, BRCA1, CDKN1A, CHEK1, CHEK2, GADD45A, JUN, MAPK8, MDM2, MRE11A, NBS1, NFKB1, NFKBIA, RAD50, RAD51, RBBP8, RELA, TP53, TP73 17 ABL1(4), CDKN1A(2), MDM2(1), RAD51(1), RELA(2) 8873589 10 6 10 0 3 1 2 1 3 0 0.0900 0.893 1.000 273 PROSTAGLANDIN_SYNTHESIS_REGULATION ANXA1, ANXA2, ANXA3, ANXA4, ANXA5, ANXA6, ANXA8, CYP11A1, EDN1, EDNRA, EDNRB, HPGD, HSD11B1, HSD11B2, PLA2G4A, PRL, PTGDR, PTGDS, PTGER1, PTGER2, PTGER4, PTGFR, PTGIR, PTGIS, PTGS1, PTGS2, S100A6, SCGB1A1, TBXAS1 27 ANXA2(1), ANXA4(1), ANXA6(1), HPGD(1), HSD11B1(1), PLA2G4A(2), PTGIR(1), PTGS1(1), PTGS2(2), SCGB1A1(1) 8056814 12 12 12 4 2 3 1 4 2 0 0.550 0.897 1.000 274 CK1PATHWAY Caseine kinase 1 (CK1) and cdk5 phosphorylate DARPP32 in the dopamine signaling pathway. CDK5, CDK5R1, CSNK1D, DRD1, DRD2, GRM1, PLCB1, PPP1CA, PPP1R1B, PPP2CA, PPP3CA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B 17 DRD2(1), GRM1(2), PLCB1(2), PPP1CA(1), PPP3CA(1), PRKAR1A(1), PRKAR1B(1) 6260391 9 9 8 3 1 2 0 4 2 0 0.533 0.897 1.000 275 PROPANOATE_METABOLISM ABAT, ACACA, ACADL, ACADM, ACADSB, ACAS2, ACAS2L, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH9A1, ECHS1, EHHADH, HADHA, LDHA, LDHB, LDHC, MCEE, MLYCD, MUT, PCCA, PCCB, SDS, SUCLA2, SUCLG1, SUCLG2 31 ACACA(4), ACADSB(2), ACAT1(1), ALDH1A1(1), ALDH1A2(3), ALDH1A3(1), ALDH3A1(1), EHHADH(2), MUT(1) 12907888 16 14 15 3 4 1 3 7 1 0 0.238 0.898 1.000 276 ST_WNT_CA2_CYCLIC_GMP_PATHWAY Some Wnt glycoprotein/Frizzled receptor interactions increase intracellular calcium and decrease cGMP. BF, CAMK2A, CAMK2B, CAMK2D, CAMK2G, DAG1, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, NFAT5, PDE6A, PDE6B, PDE6C, PDE6D, PDE6G, PDE6H, SLC6A13, TF 19 CAMK2A(1), CAMK2D(1), DAG1(1), ITPKB(2), ITPR1(2), ITPR2(3), ITPR3(1), PDE6B(1), PDE6C(1), SLC6A13(2), TF(1) 14001885 16 14 16 3 5 3 1 3 4 0 0.260 0.898 1.000 277 INTEGRINPATHWAY Integrins are cell surface receptors commonly present at focal adhensions that interact with the extracellular matrix and transduce extracellular signaling. ACTA1, ACTN1, ACTN2, ACTN3, ARHA, BCAR1, BCR, CAPN1, CAPNS1, CAPNS2, CAV1, CRKL, CSK, FYN, GRB2, GRF2, HRAS, ITGA1, ITGB1, JUN, MAP2K1, MAP2K2, MAPK1, MAPK3, MAPK8, PPP1R12B, PTK2, PXN, RAF1, RAP1A, ROCK1, SHC1, SOS1, SRC, TLN1, TNS, VCL, ZYX 35 BCAR1(1), BCR(1), CAPNS1(1), GRB2(1), HRAS(3), MAPK1(1), PTK2(2), PXN(1), RAF1(1), ROCK1(5), SHC1(2), SOS1(1), TLN1(2) 18449494 22 20 21 3 8 2 5 4 3 0 0.0740 0.901 1.000 278 ARAPPATHWAY ADP-ribosylation factors (ARFs), members of the Ras superfamily, regulate eukaryotic vesicular trafficking and activate phospholipase D's. ARF1, ARFGAP1, ARFGAP3, ARFGEF2, BIG1, CENTD1, CENTD2, CLTA, CLTB, COP, COPA, DDEF1, DDEF2, GBF1, GPLD1, KDELR1, KDELR2, KDELR3, PSCD1, PSCD2, PSCD3, PSCD4 12 ARFGAP3(1), ARFGEF2(1), COPA(1), GBF1(1), GPLD1(1), KDELR3(1) 6324602 6 6 6 2 2 2 0 1 1 0 0.540 0.902 1.000 279 SA_MMP_CYTOKINE_CONNECTION Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix. ACE, CD44, CSF1, FCGR3A, IL1B, IL6R, SELL, SPN, TGFB1, TGFB2, TNF, TNFRSF1A, TNFRSF1B, TNFRSF8, TNFSF8 15 ACE(2), TGFB1(1), TGFB2(1), TNF(1), TNFSF8(1) 5178989 6 5 6 2 2 0 2 2 0 0 0.595 0.902 1.000 280 SA_BONE_MORPHOGENETIC Bone morphogenetic protein binds to its receptor to induce ectopic bone formation and promote development of the viscera. BMP1, BMPR1A, BMPR1B, BMPR2, MADH1, MADH4, MADH6 4 BMPR2(1) 2443656 1 1 1 1 0 0 0 1 0 0 0.957 0.902 1.000 281 STEROID_BIOSYNTHESIS CYP17A1, F13B, HSD17B1, HSD17B2, HSD17B3, HSD17B4, HSD17B7, HSD3B1, HSD3B2 9 F13B(1), HSD17B3(1), HSD17B4(1) 3149127 3 3 3 2 1 0 1 0 1 0 0.804 0.903 1.000 282 HCMVPATHWAY Cytomegalovirus activates MAP kinase pathways in the host cell, inducing transcription of viral genes. AKT1, CREB1, MAP2K1, MAP2K2, MAP2K3, MAP2K6, MAP3K1, MAPK1, MAPK14, MAPK3, NFKB1, PIK3CA, PIK3R1, RB1, RELA, SP1 16 AKT1(1), MAPK1(1), PIK3CA(10), PIK3R1(1), RB1(2), RELA(2), SP1(1) 7582276 18 17 18 5 4 5 4 4 0 1 0.389 0.903 1.000 283 DNAFRAGMENTPATHWAY DNA fragmentation during apoptosis is effected by DFF, a caspase-activated DNAse, and by endonuclease G. CASP3, CASP7, DFFA, DFFB, ENDOG, GZMB, HMGB1, HMGB2, TOP2A, TOP2B 10 DFFA(1), TOP2A(2), TOP2B(2) 3538601 5 5 5 3 1 1 0 1 2 0 0.964 0.904 1.000 284 FASPATHWAY Binding of the Fas ligand to the Fas receptor induces caspase activation and consequent apoptosis in the Fas-expressing cell. ADPRT, ARHGDIB, CASP10, CASP3, CASP6, CASP7, CASP8, CFLAR, DAXX, DFFA, DFFB, FADD, FAF1, JUN, LMNA, LMNB1, LMNB2, MAP2K4, MAP3K1, MAP3K7, MAPK8, PAK1, PAK2, PRKDC, PTPN13, RB1, RIPK2, SPTAN1, TNFRSF6, TNFSF6 27 ARHGDIB(1), DAXX(1), DFFA(1), FAF1(2), LMNA(2), MAP2K4(1), MAP3K7(2), PAK2(1), PRKDC(7), PTPN13(1), RB1(2), RIPK2(2) 15924881 23 19 23 4 8 3 4 4 3 1 0.124 0.905 1.000 285 AHSPPATHWAY Alpha-hemoglobin stabilizing protein (AHSP) prevents precitipation of hemoglobin alpha-subunits. ALAD, ALAS1, ALAS2, CPO, ERAF, FECH, GATA1, HBA1, HBA2, HBB, HMBS, UROD, UROS 12 HMBS(1) 3034259 1 1 1 1 1 0 0 0 0 0 0.914 0.905 1.000 286 GABAPATHWAY Gamma-aminobutyric acid (GABA) is an inhibitory neurotransmitter whose receptor is regulated by Plic-1, gephyrin, and GABARAP, which promote receptor clustering. DNM1, GABARAP, GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GPHN, NSF, SRC, UBQLN1 12 GABRA3(1), GABRA5(1), UBQLN1(1) 4663580 3 3 3 0 1 1 0 0 1 0 0.293 0.905 1.000 287 EGFPATHWAY The epidermal growth factor (EGF) peptide stimulates the EGF receptor to promote cell proliferation via the MAP kinase and Ras pathways. CSNK2A1, EGF, EGFR, ELK1, FOS, GRB2, HRAS, JAK1, JUN, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, RAF1, RASA1, SHC1, SOS1, SRF, STAT1, STAT3, STAT5A 26 EGFR(2), GRB2(1), HRAS(3), JAK1(3), MAP2K4(1), PIK3CA(10), PIK3R1(1), PLCG1(1), PRKCA(2), RAF1(1), SHC1(2), SOS1(1), STAT1(1), STAT3(5) 14577459 34 27 34 8 10 5 5 12 2 0 0.215 0.911 1.000 288 GLYCOLYSISPATHWAY Glycolysis is an evolutionarily conserved pathway by which one glucose molecule is converted to two pyruvate molecules for a gain of 2 ATP. ALDOB, ENO1, GAPD, GPI, HK1, PFKL, PGAM1, PGK1, PKLR, TPI1 9 ENO1(2), PFKL(1) 3642995 3 3 3 2 1 0 0 0 2 0 0.872 0.914 1.000 289 FOLATE_BIOSYNTHESIS ALPI, ALPL, ALPP, ALPP, ALPPL2, ALPPL2, DHFR, FPGS, GCH1, GGH, SPR 9 ALPI(1), ALPP(1), ALPPL2(1), DHFR(1) 2584097 4 4 4 3 2 1 0 0 1 0 0.874 0.917 1.000 290 P53PATHWAY p53 induces cell cycle arrest or apoptosis under conditions of DNA damage. APAF1, ATM, BAX, BCL2, CCND1, CCNE1, CDK2, CDK4, CDKN1A, E2F1, GADD45A, MDM2, PCNA, RB1, TIMP3, TP53 14 APAF1(1), CDKN1A(2), MDM2(1), RB1(2) 4302296 6 4 6 2 2 1 1 0 1 1 0.607 0.917 1.000 291 HSA00980_METABOLISM_OF_XENOBIOTICS_BY_CYTOCHROME_P450 Genes involved in metabolism of xenobiotics by cytochrome P450 ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AKR1C1, AKR1C2, AKR1C3, AKR1C4, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, CYP1A1, CYP1A2, CYP1B1, CYP2B6, CYP2C18, CYP2C19, CYP2C8, CYP2C9, CYP2E1, CYP2F1, CYP2S1, CYP3A4, CYP3A43, CYP3A5, CYP3A7, DHDH, EPHX1, GSTA1, GSTA2, GSTA3, GSTA4, GSTA5, GSTK1, GSTM1, GSTM2, GSTM3, GSTM4, GSTM5, GSTO2, GSTP1, GSTT1, GSTT2, GSTZ1, MGST1, MGST2, MGST3, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7 69 ADH1B(1), ADH4(1), ADH6(1), AKR1C4(1), ALDH1A3(1), ALDH3A1(1), ALDH3B1(1), CYP1A1(1), CYP1A2(1), CYP2B6(2), CYP2C18(1), CYP2C8(3), CYP2F1(2), CYP2S1(1), CYP3A43(1), CYP3A7(1), EPHX1(2), GSTA2(1), GSTM2(1), GSTM5(2), GSTO2(1), UGT1A4(1), UGT1A7(1), UGT1A8(2), UGT1A9(1), UGT2A1(1), UGT2A3(1), UGT2B10(2), UGT2B11(2), UGT2B15(1), UGT2B17(1), UGT2B28(2), UGT2B7(1) 22355242 43 35 43 8 10 3 8 15 7 0 0.106 0.920 1.000 292 HSA00531_GLYCOSAMINOGLYCAN_DEGRADATION Genes involved in glycosaminoglycan degradation ARSB, GALNS, GLB1, GNS, GUSB, HEXA, HEXB, HGSNAT, HPSE, HPSE2, HYAL1, HYAL2, IDS, IDUA, LCT, NAGLU, SPAM1 17 ARSB(1), GALNS(2), HEXB(1), LCT(3), SPAM1(2) 8002072 9 8 9 2 4 1 0 3 1 0 0.476 0.920 1.000 293 FBW7PATHWAY Cyclin E interacts with cell cycle checkpoint kinase cdk2 to allow transcription of genes required for S phase, including transcription of additional cyclin E. CCNE1, CDC34, CDK2, CUL1, E2F1, FBXW7, RB1, SKP1A, TFDP1 8 RB1(2), TFDP1(1) 3212297 3 3 3 2 0 0 2 0 0 1 0.810 0.921 1.000 294 HSA00625_TETRACHLOROETHENE_DEGRADATION Genes involved in tetrachloroethene degradation AKR1B10, EPHX2, HSD3B7, RDH11, RDH12, RDH13, RDH14 7 RDH12(1) 1878306 1 1 1 0 1 0 0 0 0 0 0.673 0.923 1.000 295 PDGFPATHWAY Platelet-derived growth factor (PDGF) receptor is phosphorylated on ligand binding and promotes cell proliferation. CSNK2A1, ELK1, FOS, GRB2, HRAS, JAK1, JUN, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, PDGFA, PDGFRA, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, RAF1, RASA1, SHC1, SOS1, SRF, STAT1, STAT3, STAT5A 26 GRB2(1), HRAS(3), JAK1(3), MAP2K4(1), PDGFRA(2), PIK3CA(10), PIK3R1(1), PLCG1(1), PRKCA(2), RAF1(1), SHC1(2), SOS1(1), STAT1(1), STAT3(5) 13577958 34 26 34 8 12 5 5 10 2 0 0.181 0.925 1.000 296 PYK2PATHWAY Pyk2 and Rac1 stimulate the JNK cascade and activate MKK3, which activates p38. BCAR1, CALM1, CALM2, CALM3, CRKL, GNAQ, GRB2, HRAS, JUN, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP3K1, MAPK1, MAPK14, MAPK3, MAPK8, PAK1, PLCG1, PRKCA, PRKCB1, PTK2B, RAC1, RAF1, SHC1, SOS1, SRC, SYT1 28 BCAR1(1), GRB2(1), HRAS(3), MAP2K4(1), MAPK1(1), PLCG1(1), PRKCA(2), RAC1(1), RAF1(1), SHC1(2), SOS1(1), SYT1(1) 11113431 16 14 16 4 9 1 3 2 1 0 0.328 0.926 1.000 297 HSA00400_PHENYLALANINE_TYROSINE_AND_TRYPTOPHAN_BIOSYNTHESIS Genes involved in phenylalanine, tyrosine and tryptophan biosynthesis FARS2, FARSA, FARSB, GOT1, GOT2, PAH, TAT, YARS, YARS2 9 FARSB(2), GOT1(1), PAH(1), YARS2(1) 3385332 5 4 5 2 3 0 0 1 1 0 0.644 0.926 1.000 298 HSA00760_NICOTINATE_AND_NICOTINAMIDE_METABOLISM Genes involved in nicotinate and nicotinamide metabolism AOX1, BST1, C9orf95, CD38, ENPP1, ENPP3, NADK, NADSYN1, NMNAT1, NMNAT2, NMNAT3, NNMT, NNT, NP, NT5C, NT5C1A, NT5C1B, NT5C2, NT5C3, NT5E, NT5M, NUDT12, PBEF1, QPRT 22 AOX1(1), CD38(1), ENPP1(2), ENPP3(1), NADK(2), NADSYN1(1), NNMT(1), NNT(2), NT5C1B(1), NT5C2(2), NT5M(1), NUDT12(1) 8406672 16 14 16 5 6 3 1 2 4 0 0.422 0.929 1.000 299 HSA04130_SNARE_INTERACTIONS_IN_VESICULAR_TRANSPORT Genes involved in SNARE interactions in vesicular transport BET1, BET1L, BNIP1, C1orf142, GOSR1, GOSR2, SEC22B, SNAP23, SNAP25, SNAP29, STX10, STX11, STX12, STX16, STX17, STX18, STX19, STX2, STX3, STX4, STX5, STX6, STX7, STX8, TSNARE1, USE1, VAMP1, VAMP2, VAMP3, VAMP4, VAMP5, VAMP7, VAMP8, VTI1A, VTI1B, YKT6 35 BET1(1), BNIP1(2), SNAP25(2), VAMP1(1), VAMP5(1), VAMP7(1), VTI1A(1) 6549278 9 8 9 2 4 0 1 2 2 0 0.470 0.929 1.000 300 ST_GRANULE_CELL_SURVIVAL_PATHWAY The survival and differentiation of granule cells in the brain is controlled by pro-growth PACAP and pro-apoptotic ceramides. ADPRT, APC, ASAH1, CAMP, CASP3, CERK, CREB1, CREB3, CREB5, CXCL2, DAG1, EPHB2, FOS, GNAQ, IL8RB, ITPKA, ITPKB, JUN, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, PACAP 25 APC(2), ASAH1(1), CERK(1), CREB3(1), DAG1(1), EPHB2(3), ITPKB(2), MAP2K4(1), MAP2K7(2), MAPK1(1), MAPK8IP3(2) 11203433 17 15 17 4 7 2 0 3 5 0 0.434 0.930 1.000 301 ALTERNATIVEPATHWAY The alternative complement pathway is an antibody-independent mechanism of immune activation that results in cell lysis via the membrane attack complex. BF, C3, C5, C6, C7, C8A, C9, DF, PFC 6 C3(1), C6(2), C9(1) 4885869 4 4 4 2 1 1 0 0 2 0 0.674 0.930 1.000 302 41BBPATHWAY TNF-type receptor 4-1BB is bound by TRAF1 to activate the MAP kinase pathway in activated T cells. ATF2, CHUK, IFNG, IKBKB, IL2, IL4, JUN, MAP3K1, MAP3K5, MAP4K5, MAPK14, MAPK8, NFKB1, NFKBIA, RELA, TNFRSF9, TNFSF9, TRAF2 18 ATF2(1), IL4(1), MAP3K5(1), RELA(2), TRAF2(3) 7567245 8 7 8 2 3 1 1 3 0 0 0.550 0.931 1.000 303 SIG_INSULIN_RECEPTOR_PATHWAY_IN_CARDIAC_MYOCYTES Genes related to the insulin receptor pathway AKT1, AKT2, AKT3, BRD4, CAP1, CBL, CDC42, CDKN2A, F2RL2, FLOT1, FLOT2, FOXO1A, GRB2, GSK3A, GSK3B, IGFBP1, INPPL1, IRS1, IRS2, IRS4, LNPEP, MAPK1, MAPK3, PARD3, PARD6A, PDK1, PIK3CA, PIK3CD, PIK3R1, PPYR1, PSCD3, PTEN, PTPN1, RAF1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SERPINB6, SFN, SHC1, SLC2A4, SORBS1, SOS1, SOS2, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ 48 AKT1(1), AKT2(1), BRD4(2), CAP1(1), CDKN2A(1), GRB2(1), GSK3A(2), GSK3B(1), IRS1(2), IRS2(1), IRS4(3), MAPK1(1), PDK1(1), PIK3CA(10), PIK3R1(1), PTPN1(1), RAF1(1), RPS6KA1(1), SHC1(2), SORBS1(2), SOS1(1), YWHAH(1), YWHAQ(1) 23023644 39 33 39 7 10 7 4 10 8 0 0.0868 0.931 1.000 304 SA_PROGRAMMED_CELL_DEATH Programmed cell death, or apoptosis, eliminates damaged or unneeded cells. APAF1, BAD, BAK1, BAX, BCL10, BCL2, BCL2L1, BCL2L11, BID, CASP8AP2, CASP9, CES1 12 APAF1(1), CES1(1) 4218322 2 2 2 0 0 1 0 1 0 0 0.565 0.931 1.000 305 EIF2PATHWAY Eukaryotic initiation factor 2 (EIF2) initiates translation by transferring Met-tRNA to the 40S ribosome in a GTP-dependent process. EIF2AK3, EIF2AK4, EIF2B5, EIF2S1, EIF2S2, EIF2S3, EIF5, GSK3B, HRI, PPP1CA, PRKR 9 EIF2AK3(4), EIF2AK4(1), GSK3B(1), PPP1CA(1) 4483911 7 7 7 3 1 0 2 2 2 0 0.686 0.932 1.000 306 ERYTHPATHWAY Erythropoietin selectively stimulates erythrocyte differentiation from CFU-GEMM cells in bone marrow. CCL3, CSF2, CSF3, EPO, FLT3, IGF1, IL11, IL1A, IL3, IL6, IL9, KITLG, TGFB1, TGFB2, TGFB3 15 FLT3(1), IL6(1), IL9(1), TGFB1(1), TGFB2(1) 3237606 5 5 5 4 0 1 2 1 1 0 0.938 0.932 1.000 307 KERATAN_SULFATE_BIOSYNTHESIS B3GNT1, B4GALT1, B4GALT2, B4GALT3, B4GALT5, FUT8, SIAT4A, SIAT4B, SIAT6, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4 10 B4GALT1(2), B4GALT2(1), ST3GAL1(2) 3087543 5 4 5 2 5 0 0 0 0 0 0.747 0.934 1.000 308 OXIDATIVE_PHOSPHORYLATION ATP12A, ATP4B, ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, ATP7A, ATP7B, COX10, COX4I1, COX5A, COX5B, COX6A1, COX6A2, COX6B1, COX6C, COX7A1, COX7A2, COX7B, COX7C, COX8A, NDUFA1, NDUFA10, NDUFA11, NDUFA4, NDUFA5, NDUFA8, NDUFB2, NDUFB4, NDUFB5, NDUFB6, NDUFB7, NDUFS1, NDUFS2, NDUFV1, NDUFV2, PP, PPA2, SDHA, SDHA, SDHAL2, SDHB, UQCRB, UQCRC1, UQCRFS1, UQCRH 60 ATP12A(1), ATP6V1A(2), ATP6V1B1(1), ATP6V1C2(3), ATP6V1F(1), ATP6V1H(1), ATP7B(1), NDUFA10(2), NDUFB7(1), NDUFV1(1), SDHA(1), SHMT1(1), UQCRC1(1) 14881166 17 16 17 3 2 2 3 8 2 0 0.310 0.935 1.000 309 IL22BPPATHWAY IL-22 is produced by T cells and induces the acute phase inflammatory response in hepatocytes. IL10RA, IL22, IL22RA1, IL22RA2, JAK1, JAK2, JAK3, SOCS3, STAT1, STAT3, STAT5A, STAT5B, TYK2 13 IL10RA(2), JAK1(3), STAT1(1), STAT3(5), STAT5B(1), TYK2(1) 7214167 13 11 13 5 0 3 2 4 4 0 0.675 0.936 1.000 310 EPHA4PATHWAY Eph Kinases and ephrins support platelet aggregation ACTA1, EPHA4, EPHB1, FYN, ITGA1, ITGB1, L1CAM, LYN, RAP1B, SELP 10 EPHA4(1), EPHB1(3), L1CAM(3), SELP(2) 6136060 9 8 9 3 4 0 2 1 2 0 0.569 0.939 1.000 311 PLK3PATHWAY Active Plk3 phosphorylates CDC25c, blocking the G2/M transition, and phosphorylates p53 to induce apoptosis. ATM, ATR, CDC25C, CHEK1, CHEK2, CNK, TP53, YWHAH 5 YWHAH(1) 3461682 1 1 1 1 0 1 0 0 0 0 0.954 0.943 1.000 312 CCR3PATHWAY CCR3 is a G-protein coupled receptor that recruits eosinophils to inflammation sites via chemokine ligands. ARHA, CCL11, CCR3, CFL1, GNAQ, GNAS, GNB1, GNGT1, HRAS, LIMK1, MAP2K1, MAPK1, MAPK3, MYL2, NOX1, PIK3C2G, PLCB1, PPP1R12B, PRKCA, PRKCB1, PTK2, RAF1, ROCK2 21 CFL1(1), GNAS(2), GNB1(1), GNGT1(1), HRAS(3), LIMK1(1), MAPK1(1), PLCB1(2), PRKCA(2), PTK2(2), RAF1(1) 9771787 17 12 17 3 6 2 2 6 1 0 0.282 0.943 1.000 313 HSA00602_GLYCOSPHINGOLIPID_BIOSYNTHESIS_NEO_LACTOSERIES Genes involved in glycosphingolipid biosynthesis - neo-lactoseries ABO, B3GNT1, B3GNT2, B3GNT3, B3GNT4, B3GNT5, B4GALT1, B4GALT2, B4GALT3, B4GALT4, FUT1, FUT2, FUT3, FUT4, FUT5, FUT6, FUT7, FUT9, GCNT2, ST3GAL6, ST8SIA1 21 B3GNT3(1), B3GNT4(2), B4GALT1(2), B4GALT2(1), FUT1(1), FUT2(1), FUT3(1), GCNT2(1), ST8SIA1(1) 6331490 11 10 11 4 3 3 1 2 1 1 0.611 0.944 1.000 314 CIRCADIAN_EXERCISE ARNTL, AZIN1, BTG1, C10orf110, C1orf1, CBX3, CEBPB, CLDN5, CLOCK, CRY1, CRY2, DAZAP2, DAZAP2, LOC401029, DNAJA1, EIF4G2, ETV6, G0S2, GENX_3414, GFRA1, GSTM3, GSTP1, HERPUD1, HLA_DMA, HSPA8, IDI1, KLF9, MAP3K7IP2, MYF6, NCKAP1, NCOA4, NR1D2, OAZIN, PER1, PER2, PIGF, PPP1R3C, PPP2CB, PSMA4, PURA, SF3A3, SUMO3, TOB1, TUBB3, UCP3, UGP2, VAPA, ZFR 40 CEBPB(1), CRY2(2), EIF4G2(1), HERPUD1(1), HSPA8(2), NCOA4(2), NR1D2(1), PER1(1), PER2(1), SF3A3(1), SUMO3(1), TUBB3(1), UCP3(1), UGP2(1), VAPA(1), ZFR(1) 14266932 19 15 19 4 3 1 3 8 4 0 0.404 0.945 1.000 315 PPARGPATHWAY PPAR-gamma is a nuclear hormone receptor that is activated by fatty acids and regulates transcription through co-activations like Src-1 and Tif2. CREBBP, EP300, LPL, NCOA1, NCOA2, PPARBP, PPARG, PPARGC1, RXRA 7 CREBBP(4), EP300(4), PPARG(1) 7201458 9 9 9 3 4 0 2 2 1 0 0.588 0.946 1.000 316 HSA00511_N_GLYCAN_DEGRADATION Genes involved in N-glycan degradation AGA, FLJ21865, FUCA1, FUCA2, GLB1, HEXA, HEXB, LCT, MAN2B1, MAN2B2, MAN2C1, MANBA, NEU1, NEU2, NEU3, NEU4 15 AGA(2), FUCA2(1), HEXB(1), LCT(3), MAN2B2(1), MAN2C1(1), NEU1(1), NEU4(1) 8006100 11 8 11 3 5 1 1 1 3 0 0.473 0.947 1.000 317 ST_TYPE_I_INTERFERON_PATHWAY Type I interferon is an antiviral cytokine that induces a JAK-STAT type pathway leading to ISGF3 activation and a cellular antiviral response. IFNAR1, IFNB1, ISGF3G, JAK1, PTPRU, REG1A, STAT1, STAT2, TYK2 8 JAK1(3), PTPRU(2), STAT1(1), TYK2(1) 4892224 7 6 7 3 1 1 0 3 2 0 0.781 0.947 1.000 318 GLYCOSPHINGOLIPID_METABOLISM ARSA, ARSB, ARSD, ARSE, ASAH1, GAL3ST1, GALC, GBA, GBAP, GLA, GLB1, LCT, NEU1, NEU2, NEU3, NEU4, PPAP2A, PPAP2B, PPAP2C, SMPD1, SMPD2, SPTLC1, SPTLC2, UGCG 23 ARSB(1), ARSE(2), ASAH1(1), GAL3ST1(1), LCT(3), NEU1(1), NEU4(1), PPAP2A(1), PPAP2B(1) 9469308 12 10 12 2 4 2 2 3 1 0 0.205 0.947 1.000 319 HSA00710_CARBON_FIXATION Genes involved in carbon fixation ALDOA, ALDOB, ALDOC, FBP1, FBP2, GOT1, GOT2, GPT, GPT2, MDH1, MDH2, ME1, ME3, PGK1, PGK2, PKLR, PKM2, RPE, RPIA, TKT, TKTL1, TKTL2, TPI1 23 ALDOC(1), GOT1(1), ME1(2), ME3(1), PGK2(1), TKT(1) 7883067 7 7 7 2 0 1 1 4 1 0 0.526 0.948 1.000 320 SETPATHWAY Cytotoxic T cells release perforin, which to allow entry into target cells of granzyme B, which activates caspases, and granzyme A, which induces caspase-independent apoptosis. ANP32A, APEX1, CREBBP, DFFA, DFFB, GZMA, GZMB, HMGB2, NME1, PRF1, SET 11 CREBBP(4), DFFA(1), GZMA(1), PRF1(1) 4144084 7 7 7 4 3 1 0 1 2 0 0.881 0.950 1.000 321 MYOSINPATHWAY Myosin light chain kinase phosphorylates myosin and promotes muscle contraction and platelet formation; myosin phosphatase antagonizes these processes. ARHGAP5, ARHGEF1, GNA12, GNA13, GNAQ, GNB1, GNGT1, MYL2, MYLK, PLCB1, PPP1R12B, PRKCA, PRKCB1, PRKCL1, ROCK1 13 ARHGEF1(3), GNA13(1), GNB1(1), GNGT1(1), MYLK(3), PLCB1(2), PRKCA(2), ROCK1(5) 8044060 18 16 17 5 4 2 4 6 2 0 0.492 0.955 1.000 322 HSA03050_PROTEASOME Genes involved in proteasome PSMA1, PSMA2, PSMA3, PSMA4, PSMA5, PSMA6, PSMA7, PSMB1, PSMB2, PSMB3, PSMB4, PSMB5, PSMB6, PSMB7, PSMC2, PSMC3, PSMD1, PSMD11, PSMD12, PSMD13, PSMD2, PSMD6 22 PSMA2(1), PSMD1(1), PSMD2(1), PSMD6(1) 6234289 4 4 4 0 1 0 0 3 0 0 0.421 0.959 1.000 323 PROTEASOME PSMA1, PSMA2, PSMA3, PSMA4, PSMA5, PSMA6, PSMA7, PSMB1, PSMB10, PSMB2, PSMB3, PSMB4, PSMB5, PSMB6, PSMB7, PSMB8, PSMB9 17 PSMA2(1) 3405192 1 1 1 0 0 0 0 1 0 0 0.825 0.959 1.000 324 CCR5PATHWAY CCR5 is a G-protein coupled receptor expressed in macrophages that recognizes chemokine ligands and is targeted by the HIV envelope protein GP120. CALM1, CALM2, CALM3, CCL2, CCL4, CCR5, CXCL12, CXCR4, FOS, GNAQ, JUN, MAPK14, MAPK8, PLCG1, PRKCA, PRKCB1, PTK2B, SYT1 17 PLCG1(1), PRKCA(2), SYT1(1) 5370437 4 4 4 1 3 0 0 1 0 0 0.534 0.959 1.000 325 CREBPATHWAY CREB is a transcription factor that binds to cAMP-responsive elements (CREs) to activate transcription in response to extracellular signaling. ADCY1, AKT1, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CREB1, GNAS, GRB2, HRAS, MAPK1, MAPK14, MAPK3, PIK3CA, PIK3R1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, RAC1, RPS6KA1, RPS6KA5, SOS1 26 ADCY1(1), AKT1(1), CAMK2A(1), CAMK2D(1), GNAS(2), GRB2(1), HRAS(3), MAPK1(1), PIK3CA(10), PIK3R1(1), PRKAR1A(1), PRKAR1B(1), PRKCA(2), RAC1(1), RPS6KA1(1), RPS6KA5(3), SOS1(1) 11386378 32 27 32 9 10 5 4 13 0 0 0.404 0.960 1.000 326 CITRATE_CYCLE_TCA_CYCLE ACO1, ACO2, CS, DLD, DLST, DLSTP, FH, IDH1, IDH2, IDH3A, IDH3B, IDH3G, MDH1, MDH2, PC, PCK1, SDHA, SDHA, SDHAL2, SDHB, SUCLA2, SUCLG1, SUCLG2 19 ACO2(1), FH(1), IDH3A(1), PC(1), SDHA(1) 7680804 5 5 5 1 0 0 1 3 1 0 0.675 0.960 1.000 327 HSA05050_DENTATORUBROPALLIDOLUYSIAN_ATROPHY Genes involved in dentatorubropallidoluysian atrophy (DRPLA) ATN1, BAIAP2, CASP1, CASP3, CASP7, CASP8, GAPDH, INS, INSR, ITCH, MAGI1, MAGI2, RERE, WWP1, WWP2 15 CASP1(2), RERE(2), WWP1(2) 9363347 6 6 6 1 2 1 0 2 1 0 0.416 0.960 1.000 328 PROSTAGLANDIN_AND_LEUKOTRIENE_METABOLISM AKR1C3, ALOX12, ALOX15, ALOX5, CBR1, CBR3, CYP4F2, CYP4F3, CYP4F3, CYP4F2, EPX, GGT1, LPO, LTA4H, MPO, PGDS, PLA2G1B, PLA2G2A, PLA2G2E, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PRDX1, PRDX2, PRDX5, PRDX6, PTGDS, PTGES2, PTGIS, PTGS1, PTGS2, TBXAS1, TPO 31 ALOX15(1), CYP4F2(1), EPX(1), LPO(1), PLA2G2A(1), PLA2G4A(2), PLA2G6(1), PTGS1(1), PTGS2(2), TPO(1) 10933042 12 12 12 3 3 4 0 5 0 0 0.352 0.961 1.000 329 HSA04120_UBIQUITIN_MEDIATED_PROTEOLYSIS Genes involved in ubiquitin mediated proteolysis ANAPC1, ANAPC10, ANAPC11, ANAPC2, ANAPC4, ANAPC5, ANAPC7, BTRC, CDC16, CDC20, CDC23, CDC26, CDC27, CUL1, CUL2, CUL3, FBXW11, FBXW7, FZR1, ITCH, LOC728919, RBX1, SKP1, SKP2, SMURF1, SMURF2, TCEB1, TCEB2, UBA1, UBE2C, UBE2D1, UBE2D2, UBE2D3, UBE2D4, UBE2E1, UBE2E2, UBE2E3, VHL, WWP1, WWP2 39 ANAPC1(1), ANAPC2(1), ANAPC5(3), CDC23(1), CUL2(2), CUL3(3), FBXW11(1), FZR1(2), TCEB2(1), UBA1(1), VHL(1), WWP1(2) 15619271 19 18 19 4 1 2 7 7 2 0 0.251 0.961 1.000 330 COMPPATHWAY Both the classic and alternative immune complement pathways promote inflammation, foreign cell lysis, and phagocytosis. BF, C1QA, C1QB, C1QG, C1R, C1S, C2, C3, C4A, C4B, C5, C6, C7, C8A, C9, DF, MASP1, MASP2, MBL2 14 C1S(1), C3(1), C6(2), C9(1), MASP1(2), MASP2(1) 8307730 8 8 8 3 2 1 1 2 2 0 0.548 0.961 1.000 331 TIDPATHWAY On ligand binding, interferon gamma receptors stimulate JAK2 kinase to phosphorylate STAT transcription factors, which promote expression of interferon responsive genes. DNAJA3, HSPA1A, IFNG, IFNGR1, IFNGR2, IKBKB, JAK2, LIN7A, NFKB1, NFKBIA, RB1, RELA, TIP-1, TNF, TNFRSF1A, TNFRSF1B, TP53, USH1C, WT1 17 RB1(2), RELA(2), TNF(1) 6801936 5 5 5 2 1 1 2 0 0 1 0.600 0.962 1.000 332 RELAPATHWAY Acetylated NF-kB proteins are immune to IkB regulation and promote transcription until the histone deacetylase HDAC3 deacetylates the RelA subunit of NF-kB. CHUK, CREBBP, EP300, FADD, HDAC3, IKBKB, IKBKG, NFKB1, NFKBIA, RELA, RIPK1, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF6 15 CREBBP(4), EP300(4), RELA(2), RIPK1(1), TNF(1) 8754647 12 12 12 4 5 1 3 2 1 0 0.524 0.962 1.000 333 NFKBPATHWAY Inactive nuclear factor kB (NF-kB) is inhibited by the IkB family in the cytoplasm; active NF-kB is localized in the nucleus and regulates transcription of a variety of genes. CHUK, FADD, IKBKB, IKBKG, IL1A, IL1R1, IRAK1, MAP3K1, MAP3K14, MAP3K7, MAP3K7IP1, MYD88, NFKB1, NFKBIA, RELA, RIPK1, TLR4, TNF, TNFAIP3, TNFRSF1A, TNFRSF1B, TRADD, TRAF6 21 IRAK1(1), MAP3K7(2), RELA(2), RIPK1(1), TNF(1), TNFAIP3(1) 9505535 8 8 8 2 3 1 2 0 2 0 0.408 0.964 1.000 334 PMLPATHWAY Ring-shaped PML nuclear bodies regulate transcription and are required co-activators in p53- and DAXX-mediated apoptosis. CREBBP, DAXX, HRAS, PAX3, PML, PRAM-1, RARA, RB1, SIRT1, SP100, TNF, TNFRSF1A, TNFRSF1B, TNFRSF6, TNFSF6, TP53, UBL1 12 CREBBP(4), DAXX(1), HRAS(3), PML(3), RB1(2), SIRT1(1), SP100(2), TNF(1) 7112684 17 15 17 5 7 2 5 1 1 1 0.321 0.964 1.000 335 IL12PATHWAY IL12 and Stat4 Dependent Signaling Pathway in Th1 Development CCR5, CD3D, CD3E, CD3G, CD3Z, CXCR3, ETV5, IFNG, IL12A, IL12B, IL12RB1, IL12RB2, IL18, IL18R1, JAK2, JUN, MAP2K6, MAPK14, MAPK8, STAT4, TRA@, TRB@, TYK2 20 ETV5(1), IL12A(1), IL12RB2(1), STAT4(3), TYK2(1) 7267183 7 7 7 4 0 1 1 1 4 0 0.843 0.965 1.000 336 PYRUVATE_METABOLISM ACACA, ACAS2, ACAS2L, ACAT1, ACAT2, ACYP1, ACYP2, ADH5, AKR1B1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, CACH_1, DLAT, DLD, GLO1, GRHPR, HAGH, HAGHL, LDHA, LDHB, LDHC, LDHD, MDH1, MDH2, ME1, ME2, ME3, PC, PCK1, PDHA1, PDHA2, PDHB, PKLR, PKM2 37 ACACA(4), ACAT1(1), ALDH1A1(1), ALDH1A2(3), ALDH1A3(1), ALDH3A1(1), ME1(2), ME3(1), PC(1), PDHA2(2) 14430396 17 17 16 4 4 1 2 8 2 0 0.321 0.966 1.000 337 AMINOACYL_TRNA_BIOSYNTHESIS AARS, CARS, DARS, EPRS, FARS2, FARSLB, GARS, HARS, HARSL, IARS, KARS, LARS, LARS2, MARS, MARS2, NARS, QARS, RARS, SARS, TARS, WARS, WARS2, YARS 21 AARS(1), CARS(1), EPRS(2), GARS(1), IARS(1), KARS(1), LARS(1), LARS2(2), MARS2(1), QARS(1), SARS(1), TARS(1), WARS(1) 12453700 15 13 15 4 4 2 2 4 3 0 0.546 0.966 1.000 338 AKAP13PATHWAY A-kinase anchor protein 13 (AKAP13) localizes protein kinase A holoenzyme and is a nucleotide exchange factor for Rho/Rac. AKAP13, ARHA, EDG2, EDG4, EDG7, GNA12, PRKACB, PRKACG, PRKAG1, PRKAR2A, PRKAR2B 7 AKAP13(1), PRKAG1(2) 3934067 3 3 3 2 0 0 2 1 0 0 0.861 0.967 1.000 339 HSA00271_METHIONINE_METABOLISM Genes involved in methionine metabolism AHCY, AMD1, BHMT, CBS, CTH, DNMT1, DNMT3A, DNMT3B, KIAA0828, MARS, MARS2, MAT1A, MAT2B, MTAP, MTFMT, MTR, SRM, TAT 17 AHCY(1), CBS(1), CTH(1), DNMT1(2), DNMT3A(2), DNMT3B(1), MARS2(1), MAT1A(1) 8115169 10 10 10 4 2 2 2 0 4 0 0.640 0.969 1.000 340 BADPATHWAY When phosphorylated, BAD is inhibited by sequestration; when non-phosphorylated, it promotes apoptosis by inactivating pro-survival BCL-XL and BCL-2. ADCY1, AKT1, BAD, BAX, BCL2, BCL2L1, CSF2RB, IGF1, IGF1R, IL3, IL3RA, KIT, KITLG, PIK3CA, PIK3R1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, YWHAH 22 ADCY1(1), AKT1(1), IGF1R(1), IL3RA(1), PIK3CA(10), PIK3R1(1), PRKAR1A(1), PRKAR1B(1), YWHAH(1) 8575880 18 16 18 6 3 4 4 7 0 0 0.558 0.970 1.000 341 RNA_POLYMERASE POLR1B, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLRMT 14 POLR1B(1), POLR2A(2) 5278515 3 3 3 1 2 0 0 1 0 0 0.768 0.970 1.000 342 NDKDYNAMINPATHWAY Endocytotic role of NDK, Phosphins and Dynamin AMPH, AP2A1, AP2M1, BIN1, CALM1, CALM2, CALM3, DNM1, EPN1, EPS15, NME1, NME2, PICALM, PPP3CA, PPP3CB, PPP3CC, SYNJ1, SYNJ2, SYT1 19 EPN1(1), EPS15(1), PICALM(1), PPP3CA(1), PPP3CC(1), SYNJ1(3), SYNJ2(2), SYT1(1) 8515519 11 11 11 4 1 0 1 7 2 0 0.796 0.971 1.000 343 CARBON_FIXATION ALDOA, ALDOB, ALDOC, FBP1, FBP2, GOT1, GOT2, GPT, GPT2, MDH1, MDH2, ME1, ME2, ME3, PGK1, PKLR, PKM2, RPE, RPE, LOC440001, RPIA, TKT, TPI1 21 ALDOC(1), GOT1(1), ME1(2), ME3(1), TKT(1) 7054776 6 6 6 2 0 1 0 4 1 0 0.613 0.971 1.000 344 HSA00360_PHENYLALANINE_METABOLISM Genes involved in phenylalanine metabolism ABP1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, ARD1A, DDC, EPX, ESCO1, ESCO2, GOT1, GOT2, HPD, LPO, LYCAT, MAOA, MAOB, MIF, MPO, MYST3, MYST4, NAT5, NAT6, PNPLA3, PRDX6, SH3GLB1, TAT, TPO 27 ALDH1A3(1), ALDH3A1(1), ALDH3B1(1), AOC2(1), EPX(1), ESCO1(4), GOT1(1), HPD(1), LPO(1), NAT6(1), TPO(1) 13315435 14 14 14 4 3 2 1 4 4 0 0.598 0.972 1.000 345 HSA00071_FATTY_ACID_METABOLISM Genes involved in fatty acid metabolism ACAA1, ACAA2, ACADL, ACADM, ACADS, ACADSB, ACADVL, ACAT1, ACAT2, ACOX1, ACOX3, ACSL1, ACSL3, ACSL4, ACSL5, ACSL6, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, CPT1A, CPT1B, CPT1C, CPT2, CYP4A11, CYP4A22, DCI, ECHS1, EHHADH, GCDH, HADH, HADHA, HADHB, HSD17B10, HSD17B4, PECI 47 ACAA1(2), ACAA2(1), ACADS(2), ACADSB(2), ACAT1(1), ACOX3(1), ACSL1(1), ACSL6(2), ADH1B(1), ADH4(1), ADH6(1), ALDH1A3(1), ALDH3A1(1), CPT1C(3), EHHADH(2), HADH(1), HADHB(1), HSD17B4(1) 19102058 25 20 24 4 7 3 5 5 5 0 0.0642 0.972 1.000 346 IL4PATHWAY IL-4 promotes Th2 cell differentiation via a heterodimeric receptor that activates Stat6/JAK and MAP kinase pathways. AKT1, GRB2, IL2RG, IL4, IL4R, IRS1, JAK1, JAK3, RPS6KB1, SHC1, STAT6 11 AKT1(1), GRB2(1), IL4(1), IL4R(2), IRS1(2), JAK1(3), SHC1(2), STAT6(2) 5786694 14 12 14 5 5 2 0 4 3 0 0.639 0.972 1.000 347 BUTANOATE_METABOLISM AACS, ABAT, ACADS, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH5A1, ALDH9A1, BDH, BUCS1, ECHS1, EHHADH, GAD1, GAD2, HADHA, HMGCL, L2HGDH, OXCT1, PDHA1, PDHA2, PDHB, SDHB, SDS 27 ACADS(2), ACAT1(1), ALDH1A1(1), ALDH1A2(3), ALDH1A3(1), ALDH3A1(1), ALDH5A1(1), EHHADH(2), GAD2(4), PDHA2(2) 10076472 18 18 16 6 7 2 1 6 2 0 0.430 0.973 1.000 348 CTLPATHWAY Cytotoxic T lymphocytes induce apoptosis in infected cells presenting antigen-MHC-I complexes via the perforin and Fas/Fas ligand pathways. B2M, CD3D, CD3E, CD3G, CD3Z, GZMB, HLA-A, ICAM1, ITGAL, ITGB2, PRF1, TNFRSF6, TNFSF6, TRA@, TRB@ 10 B2M(1), ITGAL(3), ITGB2(2), PRF1(1) 3418047 7 6 7 4 3 0 0 3 1 0 0.813 0.973 1.000 349 HSA00120_BILE_ACID_BIOSYNTHESIS Genes involved in bile acid biosynthesis ACAA1, ACAA2, ACAD8, ACAD9, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AKR1B10, AKR1C4, AKR1D1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, BAAT, CEL, CYP27A1, CYP7A1, HADHB, HSD3B7, LIPA, RDH11, RDH12, RDH13, RDH14, SLC27A5, SOAT1, SOAT2, SRD5A1, SRD5A2 38 ACAA1(2), ACAA2(1), ADH1B(1), ADH4(1), ADH6(1), AKR1C4(1), AKR1D1(1), ALDH1A3(1), ALDH3A1(1), CYP7A1(1), HADHB(1), RDH12(1), SOAT2(1) 12386404 14 13 14 3 3 1 4 4 2 0 0.305 0.974 1.000 350 HSA00903_LIMONENE_AND_PINENE_DEGRADATION Genes involved in limonene and pinene degradation ACOT11, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, ARD1A, CYP2C19, CYP2C9, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ECHS1, EHHADH, ESCO1, ESCO2, HADHA, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1, YOD1 26 ALDH1A3(1), ALDH3A1(1), DHRS1(1), DHRS7(1), DHRSX(1), EHHADH(2), ESCO1(4), NAT6(1) 12045738 12 12 12 3 2 1 1 4 4 0 0.488 0.975 1.000 351 WNTPATHWAY The Wnt glycoprotein binds to membrane-bound receptors such as Frizzled to activate a number of signaling pathways, including that of beta-catenin. APC, AXIN1, BTRC, CCND1, CREBBP, CSNK1A1, CSNK1D, CSNK2A1, CTBP1, CTNNB1, DVL1, FRAT1, FZD1, GSK3B, HDAC1, MADH4, MAP3K7, MAP3K7IP1, MYC, NLK, PPARD, PPP2CA, TCF1, TLE1, WIF1, WNT1 21 APC(2), CREBBP(4), FZD1(2), GSK3B(1), MAP3K7(2), NLK(1), PPARD(1), TLE1(1), WIF1(2) 10881221 16 14 16 4 6 0 3 2 5 0 0.432 0.976 1.000 352 ST_TUMOR_NECROSIS_FACTOR_PATHWAY Tumor necrosis factor is a pro-inflammatory cytokine that activates NF-kB and c-Jun. BAG4, BIRC2, BIRC3, CASP3, CASP8, CFLAR, FADD, HRB, IKBKG, JUN, MAP2K4, MAP3K3, MAP3K7, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, NR2C2, RALBP1, RIPK1, TNF, TNFAIP3, TNFRSF1A, TNFRSF1B, TRADD, TRAF2 27 BIRC2(1), MAP2K4(1), MAP3K7(2), NFKBIL1(1), RALBP1(1), RIPK1(1), TNF(1), TNFAIP3(1), TRAF2(3) 10670052 12 11 12 3 3 0 1 4 4 0 0.524 0.976 1.000 353 RANPATHWAY RanGEF (aka RCC1) and RanGFP regulate the GTP- or GDP-bound state of Ran, creating a Ran gradient across the nuclear membrane that is used in nuclear import. CHC1, RAN, RANBP1, RANBP2, RANGAP1 4 RANBP2(1) 3279597 1 1 1 1 0 0 0 0 1 0 1.000 0.977 1.000 354 STILBENE_COUMARINE_AND_LIGNIN_BIOSYNTHESIS EPX, GBA3, LPO, MPO, PRDX1, PRDX2, PRDX5, PRDX6, TPO, TYR 10 EPX(1), LPO(1), TPO(1) 3775285 3 3 3 2 1 2 0 0 0 0 0.738 0.978 1.000 355 GPCRDB_CLASS_B_SECRETIN_LIKE ADCYAP1R1, CALCR, CALCRL, CD97, CRHR1, CRHR2, ELTD1, EMR1, EMR2, GCGR, GHRHR, GIPR, GLP1R, GLP2R, GPR64, LPHN1, LPHN2, LPHN3, PTHR1, PTHR2, SCTR, VIPR1, VIPR2 20 ADCYAP1R1(2), CD97(1), ELTD1(1), EMR2(4), GLP2R(1), GPR64(1), LPHN1(1), LPHN2(3), LPHN3(6), SCTR(1), VIPR1(1) 10451171 22 20 21 7 7 2 2 7 4 0 0.417 0.979 1.000 356 ST_G_ALPHA_I_PATHWAY Gi and Go proteins are members of the same family that transduce cellular signals through both their alpha and beta subunits. AKT1, AKT2, AKT3, ASAH1, BF, BRAF, DAG1, DRD2, EGFR, EPHB2, GRB2, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, KCNJ3, KCNJ5, KCNJ9, MAPK1, PI3, PIK3CB, PITX2, PLCB1, PLCB2, PLCB3, PLCB4, RAF1, RAP1GA1, RGS20, SHC1, SOS1, SOS2, SRC, STAT3, TERF2IP 33 AKT1(1), AKT2(1), ASAH1(1), DAG1(1), DRD2(1), EGFR(2), EPHB2(3), GRB2(1), ITPKB(2), ITPR1(2), ITPR2(3), ITPR3(1), KCNJ5(1), MAPK1(1), PIK3CB(1), PITX2(1), PLCB1(2), PLCB4(3), RAF1(1), SHC1(2), SOS1(1), STAT3(5), TERF2IP(1) 22280952 38 35 38 9 10 11 3 7 7 0 0.153 0.979 1.000 357 COMPLEMENT_ACTIVATION_CLASSICAL C1QA, C1QB, C1QG, C1R, C1S, C2, C3, C4A, C4B, C5, C6, C7, C8A, C8B, C9, DAF, MASP1 13 C1S(1), C3(1), C6(2), C8B(1), C9(1), MASP1(2) 8101778 8 8 8 3 3 1 1 1 2 0 0.510 0.979 1.000 358 HSA00450_SELENOAMINO_ACID_METABOLISM Genes involved in selenoamino acid metabolism AHCY, CARM1, CBS, CTH, GGT1, GGTL3, GGTL4, HEMK1, KIAA0828, LCMT1, LCMT2, MARS, MARS2, MAT1A, MAT2B, METTL2B, METTL6, PAPSS1, PAPSS2, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, SCLY, SEPHS1, SEPHS2, WBSCR22 26 AHCY(1), CBS(1), CTH(1), MARS2(1), MAT1A(1), METTL6(1), PAPSS2(1), PRMT3(1), PRMT5(2), PRMT8(1), SEPHS1(1), SEPHS2(3) 9741956 15 15 15 5 2 2 3 3 5 0 0.629 0.980 1.000 359 ERKPATHWAY Cell growth is promoted by Ras activation of the anti-apoptotic p44/42 MAP kinase pathway. DPM2, EGFR, ELK1, GNAS, GNB1, GNGT1, GRB2, HRAS, IGF1R, ITGB1, KLK2, MAP2K1, MAP2K2, MAPK1, MAPK3, MKNK1, MKNK2, MYC, NGFB, NGFR, PDGFRA, PPP2CA, PTPRR, RAF1, RPS6KA1, RPS6KA5, SHC1, SOS1, SRC, STAT3 29 EGFR(2), GNAS(2), GNB1(1), GNGT1(1), GRB2(1), HRAS(3), IGF1R(1), KLK2(1), MAPK1(1), PDGFRA(2), RAF1(1), RPS6KA1(1), RPS6KA5(3), SHC1(2), SOS1(1), STAT3(5) 12900634 28 26 28 8 9 3 4 10 2 0 0.382 0.980 1.000 360 GLYCOLYSIS_AND_GLUCONEOGENESIS Genes involved in glycolysis and gluconeogenesis ALDOA, ALDOB, ALDOC, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, GAPDH, GAPDHS, GAPDS, GCK, GOT1, GOT2, GPI, HK1, HK2, HK3, LDHA, LDHAL6B, LDHB, LDHC, MDH1, MDH2, PC, PCK1, PDHA1, PDHA2, PDHB, PDHX, PFKL, PFKM, PFKP, PGAM1, PGAM2, PGK1, PGK2, PKLR, PKM2, TNFAIP1, TPI1 43 ALDOC(1), ENO1(2), GCK(3), GOT1(1), HK2(1), HK3(2), PC(1), PDHA2(2), PDHX(1), PFKL(1), PFKM(1), PFKP(1), PGK2(1) 16592326 18 18 18 4 6 1 2 5 4 0 0.237 0.981 1.000 361 HSA00626_NAPHTHALENE_AND_ANTHRACENE_DEGRADATION Genes involved in naphthalene and anthracene degradation CARM1, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, HEMK1, LCMT1, LCMT2, METTL2B, METTL6, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, WBSCR22 18 DHRS1(1), DHRS7(1), DHRSX(1), METTL6(1), PRMT3(1), PRMT5(2), PRMT8(1) 5872205 8 8 8 4 1 0 1 3 3 0 0.849 0.981 1.000 362 HIFPATHWAY Under normal conditions, hypoxia inducible factor HIF-1 is degraded; under hypoxic conditions, it activates transcription of genes controlled by hpoxic response elements (HREs). ARNT, ASPH, COPS5, CREB1, EDN1, EP300, EPO, HIF1A, HSPCA, JUN, LDHA, NOS3, P4HB, VEGF, VHL 13 ARNT(2), ASPH(1), EP300(4), NOS3(1), VHL(1) 6639819 9 7 9 3 5 0 1 2 1 0 0.643 0.981 1.000 363 DEATHPATHWAY Death receptors such as Fas and DR3, 4, and 5 transduce pro-apoptotic signaling by oligomerizing to activate the caspase cascade. APAF1, BCL2, BID, BIRC2, BIRC3, BIRC4, CASP10, CASP3, CASP6, CASP7, CASP8, CASP9, CFLAR, CHUK, CYCS, DFFA, DFFB, FADD, GAS2, LMNA, MAP3K14, NFKB1, NFKBIA, RELA, RIPK1, SPTAN1, TNFRSF10A, TNFRSF10B, TNFRSF25, TNFSF10, TNFSF12, TRADD, TRAF2 32 APAF1(1), BIRC2(1), DFFA(1), LMNA(2), RELA(2), RIPK1(1), TNFRSF10A(1), TNFRSF10B(1), TNFSF12(1), TRAF2(3) 13072445 14 13 14 3 2 3 2 5 2 0 0.345 0.982 1.000 364 CARDIACEGFPATHWAY Cardiac hypertrophy, a response to high blood pressure, is stimulated by GPCR ligands such as angiotensin II that activate the EGF pathway. ADAM12, AGT, AGTR2, ARHA, EDN1, EDNRA, EDNRB, EGF, EGFR, FOS, HRAS, JUN, MYC, NFKB1, PLCG1, PRKCA, PRKCB1, RELA 16 ADAM12(1), EGFR(2), HRAS(3), PLCG1(1), PRKCA(2), RELA(2) 8013649 11 10 11 4 4 1 2 4 0 0 0.534 0.982 1.000 365 HSA00440_AMINOPHOSPHONATE_METABOLISM Genes involved in aminophosphonate metabolism CARM1, CHPT1, HEMK1, LCMT1, LCMT2, METTL2B, METTL6, PCYT1A, PCYT1B, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, WBSCR22 16 METTL6(1), PRMT3(1), PRMT5(2), PRMT8(1) 5489751 5 5 5 4 0 0 1 2 2 0 0.965 0.983 1.000 366 ETSPATHWAY The Ets transcription factors are activated by Ras and promote macrophage differentiation. CSF1, CSF1R, DDX20, E2F1, E2F4, ETS1, ETS2, ETV3, FOS, HDAC2, HDAC5, HRAS, JUN, NCOR2, RBL1, RBL2, SIN3A, SIN3B 18 CSF1R(2), ETV3(3), HDAC5(2), HRAS(3), NCOR2(2), RBL2(1) 10212538 13 12 13 4 4 0 4 1 4 0 0.515 0.983 1.000 367 ST_ADRENERGIC Adrenergic receptors respond to epinephrine and norepinephrine signaling. AKT1, APC, AR, ASAH1, BF, BRAF, CAMP, CCL13, CCL15, CCL16, DAG1, EGFR, GAS, GNA11, GNA15, GNAI1, GNAQ, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, KCNJ3, KCNJ5, KCNJ9, MAPK1, MAPK10, MAPK14, PHKA2, PIK3CA, PIK3CD, PIK3R1, PITX2, PTX1, PTX3, RAF1, SRC 33 AKT1(1), APC(2), ASAH1(1), DAG1(1), EGFR(2), GNAI1(1), ITPKB(2), ITPR1(2), ITPR2(3), ITPR3(1), KCNJ5(1), MAPK1(1), PHKA2(1), PIK3CA(10), PIK3R1(1), PITX2(1), RAF1(1) 20259342 32 29 32 8 8 6 4 9 5 0 0.360 0.983 1.000 368 PROTEASOMEPATHWAY Ubiquitinated proteins are targeted for proteolytic degradation by the proteasome, where they are unfolded and degraded to small peptides in an ATP-dependent process. PSMA1, PSMA2, PSMA3, PSMA4, PSMA5, PSMA6, PSMA7, PSMB1, PSMB2, PSMB3, PSMB4, PSMB5, PSMB6, PSMB7, PSMC3, PSMD14, RPN1, RPN2, UBE1, UBE2A, UBE3A 20 PSMA2(1), RPN1(1) 5024844 2 2 2 0 1 0 0 1 0 0 0.585 0.983 1.000 369 VITCBPATHWAY Vitamin C (ascorbic acid), in addition to its role in collagen modification, serves as an antioxidant and is imported into cells by Svct2 in the brain and Svct1 in intestinal epithelium. COL4A1, COL4A2, COL4A3, COL4A4, COL4A5, COL4A6, P4HB, SLC23A1, SLC23A2, SLC2A1, SLC2A3 11 COL4A1(1), COL4A2(2), COL4A3(1), COL4A4(1), COL4A5(1) 9738935 6 5 6 1 2 2 0 1 1 0 0.388 0.983 1.000 370 HSA00740_RIBOFLAVIN_METABOLISM Genes involved in riboflavin metabolism ACP1, ACP2, ACP5, ACP6, ACPP, ACPT, ENPP1, ENPP3, FLAD1, LHPP, MTMR1, MTMR2, MTMR6, PHPT1, RFK, TYR 16 ACP5(1), ACPT(1), ENPP1(2), ENPP3(1), RFK(1) 5858943 6 6 6 3 1 1 1 1 2 0 0.722 0.984 1.000 371 ST_STAT3_PATHWAY The transcription factor STAT3 is involved in cell growth regulation and is commonly upregulated in tumors. CISH, IL6, IL6R, JAK1, JAK2, JAK3, PIAS3, PTPRU, REG1A, SRC, STAT3 11 IL6(1), JAK1(3), PIAS3(1), PTPRU(2), STAT3(5) 5983665 12 10 12 5 1 3 2 4 2 0 0.731 0.984 1.000 372 EGFR_SMRTEPATHWAY EGF receptor activation inhibits SMRT, a transcriptional co-repressor that interacts with transcription factor complexes and gene silencers. EGF, EGFR, MAP2K1, MAP3K1, MAPK14, NCOR2, RARA, RXRA, THRA, THRB, ZNF145 10 EGFR(2), NCOR2(2), THRA(2) 6783177 6 6 6 2 3 0 0 2 1 0 0.576 0.984 1.000 373 HSA00061_FATTY_ACID_BIOSYNTHESIS Genes involved in fatty acid biosynthesis ACACA, ACACB, FASN, MCAT, OLAH, OXSM 6 ACACA(4), ACACB(2), FASN(1) 6267309 7 7 7 3 1 0 1 5 0 0 0.823 0.984 1.000 374 HSA05130_PATHOGENIC_ESCHERICHIA_COLI_INFECTION_EHEC Genes involved in pathogenic Escherichia coli infection - EHEC ABL1, ACTB, ACTG1, ARHGEF2, ARPC5, ARPC5L, CD14, CDC42, CDH1, CLDN1, CTNNB1, CTTN, EZR, FYN, HCLS1, ITGB1, KRT18, LOC643224, LOC654264, LY96, NCK1, NCK2, NCL, OCLN, PRKCA, RHOA, ROCK1, ROCK2, TLR4, TLR5, TUBA1A, TUBA1B, TUBA1C, TUBA3C, TUBA3D, TUBA3E, TUBA4A, TUBA8, TUBAL3, TUBB, TUBB1, TUBB2A, TUBB2B, TUBB2C, TUBB3, TUBB4, TUBB4Q, TUBB6, TUBB8, WAS, WASL, YWHAQ, YWHAZ 50 ABL1(4), ACTG1(1), ARHGEF2(2), ARPC5(1), ARPC5L(1), CDH1(4), CTTN(1), KRT18(1), PRKCA(2), ROCK1(5), TUBA1A(1), TUBA3C(3), TUBA3E(1), TUBA4A(1), TUBB1(1), TUBB2B(1), TUBB3(1), TUBB6(1), TUBB8(1), YWHAQ(1) 19775678 34 26 33 6 7 3 3 11 10 0 0.206 0.985 1.000 375 HSA05131_PATHOGENIC_ESCHERICHIA_COLI_INFECTION_EPEC Genes involved in pathogenic Escherichia coli infection - EPEC ABL1, ACTB, ACTG1, ARHGEF2, ARPC5, ARPC5L, CD14, CDC42, CDH1, CLDN1, CTNNB1, CTTN, EZR, FYN, HCLS1, ITGB1, KRT18, LOC643224, LOC654264, LY96, NCK1, NCK2, NCL, OCLN, PRKCA, RHOA, ROCK1, ROCK2, TLR4, TLR5, TUBA1A, TUBA1B, TUBA1C, TUBA3C, TUBA3D, TUBA3E, TUBA4A, TUBA8, TUBAL3, TUBB, TUBB1, TUBB2A, TUBB2B, TUBB2C, TUBB3, TUBB4, TUBB4Q, TUBB6, TUBB8, WAS, WASL, YWHAQ, YWHAZ 50 ABL1(4), ACTG1(1), ARHGEF2(2), ARPC5(1), ARPC5L(1), CDH1(4), CTTN(1), KRT18(1), PRKCA(2), ROCK1(5), TUBA1A(1), TUBA3C(3), TUBA3E(1), TUBA4A(1), TUBB1(1), TUBB2B(1), TUBB3(1), TUBB6(1), TUBB8(1), YWHAQ(1) 19775678 34 26 33 6 7 3 3 11 10 0 0.206 0.985 1.000 376 HSA03020_RNA_POLYMERASE Genes involved in RNA polymerase POLR1A, POLR1B, POLR1C, POLR1D, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLR3A, POLR3B, POLR3G, POLR3GL, POLR3H, POLR3K, ZNRD1 23 POLR1B(1), POLR1C(1), POLR2A(2), POLR3A(2), POLR3B(1) 9136704 7 7 7 2 2 2 0 2 1 0 0.635 0.985 1.000 377 HSA00641_3_CHLOROACRYLIC_ACID_DEGRADATION Genes involved in 3-chloroacrylic acid degradation ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1 15 ADH1B(1), ADH4(1), ADH6(1), ALDH1A3(1), ALDH3A1(1) 5173978 5 5 5 3 1 0 2 2 0 0 0.851 0.985 1.000 378 HSA00530_AMINOSUGARS_METABOLISM Genes involved in aminosugars metabolism AMDHD2, CHIA, CHIT1, CMAS, CTBS, CYB5R1, CYB5R3, GFPT1, GFPT2, GNE, GNPDA1, GNPDA2, GNPNAT1, HEXA, HEXB, HK1, HK2, HK3, LHPP, MTMR1, MTMR2, MTMR6, NAGK, NANS, NPL, PGM3, PHPT1, RENBP, UAP1 29 CYB5R1(1), GFPT2(2), GNPNAT1(1), HEXB(1), HK2(1), HK3(2), NAGK(1), PGM3(1) 11204002 10 10 10 3 3 0 0 4 3 0 0.694 0.986 1.000 379 HSA00600_SPHINGOLIPID_METABOLISM Genes involved in sphingolipid metabolism ARSA, ARSD, ARSE, ASAH1, ASAH3L, B4GALT6, CERK, DEGS1, DEGS2, ENPP7, FVT1, GAL3ST1, GALC, GBA, GLA, GLB1, LCT, NEU1, NEU2, NEU3, NEU4, PHCA, PPAP2A, PPAP2B, PPAP2C, SGMS1, SGMS2, SGPP1, SGPP2, SMPD1, SMPD2, SMPD3, SMPD4, SPHK1, SPHK2, SPTLC1, SPTLC2, UGCG, UGT8 36 ARSE(2), ASAH1(1), B4GALT6(1), CERK(1), DEGS2(3), ENPP7(1), GAL3ST1(1), LCT(3), NEU1(1), NEU4(1), PPAP2A(1), PPAP2B(1), SGMS1(1), SMPD3(1), SMPD4(1), SPHK2(1) 14011927 21 14 21 4 9 3 4 3 2 0 0.104 0.987 1.000 380 HSA00604_GLYCOSPHINGOLIPID_BIOSYNTHESIS_GANGLIOSERIES Genes involved in glycosphingolipid biosynthesis - ganglioseries B3GALT4, B4GALNT1, GLB1, HEXA, HEXB, LCT, SLC33A1, ST3GAL1, ST3GAL2, ST3GAL5, ST6GALNAC3, ST6GALNAC4, ST6GALNAC5, ST6GALNAC6, ST8SIA1, ST8SIA5 16 B4GALNT1(2), HEXB(1), LCT(3), SLC33A1(1), ST3GAL1(2), ST8SIA1(1) 6418517 10 8 10 5 5 1 0 2 2 0 0.809 0.988 1.000 381 ST_INTERLEUKIN_4_PATHWAY Like IL-13, IL-4 is produced by Th2 cells on activation of the T cell antigen receptor, and by mast and basophil cells on activation of the IgE receptor. AKT1, AKT2, AKT3, CISH, GRB2, IARS, IL13RA1, IL2RG, IL4, IL4R, INPP5D, JAK1, JAK2, JAK3, NR0B2, PI3, PIK3CA, PPP1R13B, RPS6KB1, SERPINA4, SHC1, SOS1, SOS2, SRC, STAT6, TYK2 26 AKT1(1), AKT2(1), GRB2(1), IARS(1), IL13RA1(1), IL4(1), IL4R(2), INPP5D(2), JAK1(3), PIK3CA(10), PPP1R13B(1), SHC1(2), SOS1(1), STAT6(2), TYK2(1) 14435626 30 25 30 9 9 5 4 7 5 0 0.404 0.988 1.000 382 CLASSICPATHWAY The classic complement pathway is initiated by antibodies and promotes phagocytosis and lysis of foreign cells as well as activating the inflammatory response. C1QA, C1QB, C1QG, C1R, C1S, C2, C3, C4A, C4B, C5, C6, C7, C8A, C9 11 C1S(1), C3(1), C6(2), C9(1) 6818260 5 5 5 3 1 1 1 0 2 0 0.731 0.988 1.000 383 APOPTOSIS_KEGG APAF1, BAD, BAX, BCL2, BCL2A1, BCL2L1, BCL2L2, BOK, CASP1, CASP1, COPl, CASP10, CASP2, CASP3, CASP4, CASP6, CASP7, CASP8, CASP9, CD40, CD40LG, CRADD, CYCS, DAXX, DFFA, DFFB, FADD, FAS, FASLG, HRK, IKBKE, LTA, MCL1, NFKB1, NFKBIA, NGFB, NGFR, NR3C1, NTRK1, PTPN13, RIPK1, SFRS2IP, TFG, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF1, TRAF2, TRAF3, TRAF6 47 APAF1(1), BCL2A1(1), CASP1(2), DAXX(1), DFFA(1), FAS(1), FASLG(1), MCL1(1), NTRK1(3), PTPN13(1), RIPK1(1), TNF(1), TRAF1(1), TRAF2(3) 17036748 19 16 19 4 6 6 2 4 1 0 0.143 0.989 1.000 384 RAC1PATHWAY Rac-1 is a Rho family G protein that stimulates formation of actin-dependent structures such as filopodia and lamellopodia. ARFIP2, CDK5, CDK5R1, CFL1, CHN1, LIMK1, MAP3K1, MYL2, MYLK, NCF2, PAK1, PDGFRA, PIK3CA, PIK3R1, PLD1, PPP1R12B, RAC1, RALBP1, RPS6KB1, TRIO, VAV1, WASF1 22 CFL1(1), LIMK1(1), MYLK(3), NCF2(2), PDGFRA(2), PIK3CA(10), PIK3R1(1), PLD1(2), RAC1(1), RALBP1(1), TRIO(4), VAV1(3) 13623845 31 27 31 9 10 2 5 10 4 0 0.393 0.989 1.000 385 HSA00720_REDUCTIVE_CARBOXYLATE_CYCLE Genes involved in reductive carboxylate cycle (CO2 fixation) ACLY, ACO1, ACO2, ACSS1, ACSS2, FH, IDH1, IDH2, LOC441996, MDH1, MDH2, SUCLA2 10 ACLY(1), ACO2(1), FH(1) 4844240 3 3 3 2 0 0 1 1 1 0 0.890 0.990 1.000 386 GATA3PATHWAY GATA-3 is a transcription factor that promotes differentiation of helper T cells into Th2 cells, which secrete cytokines IL4, IL5, and IL13. GATA3, IL13, IL4, IL5, JUNB, MAF, MAP2K3, MAPK14, NFATC1, NFATC2, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B 16 IL4(1), NFATC1(1), NFATC2(1), PRKAR1A(1), PRKAR1B(1) 4773615 5 5 5 3 1 0 1 3 0 0 0.863 0.991 1.000 387 GCRPATHWAY Corticosteroids activate the glucocorticoid receptor (GR), which inhibits NF-kB and activates Annexin-1, thus inhibiting the inflammatory response. ADRB2, AKT1, ANXA1, CALM1, CALM2, CALM3, CRN, GNAS, GNB1, GNGT1, HSPCA, NFKB1, NOS3, NPPA, NR3C1, PIK3CA, PIK3R1, RELA, SYT1 17 AKT1(1), GNAS(2), GNB1(1), GNGT1(1), NOS3(1), NPPA(1), PIK3CA(10), PIK3R1(1), RELA(2), SYT1(1) 7024067 21 19 21 7 4 5 3 8 1 0 0.670 0.991 1.000 388 MTA3PATHWAY The estrogen receptor regulates proliferation in mammary epithelia via MTA3 activation; loss of either protein is implicated in breast cancer. ALDOA, CTSD, ESR1, GAPD, GREB1, HSPB1, HSPB2, MTA1, MTA3, PDZK1, TUBA1, TUBA2, TUBA3, TUBA4, TUBA6, TUBA8 10 CTSD(1), ESR1(1), MTA1(1) 4304419 3 3 3 3 1 1 0 0 1 0 0.848 0.991 1.000 389 AKAPCENTROSOMEPATHWAY Protein Kinase A at the Centrosome AKAP9, ARHA, CDC2, MAP2, PCNT1, PCNT2, PPP1CA, PPP2CA, PRKACB, PRKACG, PRKAG1, PRKAR2A, PRKAR2B, PRKCE, PRKCL1 10 AKAP9(5), PPP1CA(1), PRKAG1(2) 7060256 8 8 8 5 0 0 1 5 2 0 0.935 0.991 1.000 390 CERAMIDEPATHWAY Ceramide is a lipid signaling molecule that can activate proliferative or apoptotic pathways, depending on signaling context, localization, and cell type. BAD, BAX, BCL2, CASP8, CYCS, FADD, MAP2K1, MAP2K4, MAP3K1, MAPK1, MAPK3, MAPK8, NFKB1, NSMAF, PDCD8, RAF1, RELA, RIPK1, SMPD1, TNFRSF1A, TRADD, TRAF2 21 MAP2K4(1), MAPK1(1), NSMAF(1), RAF1(1), RELA(2), RIPK1(1), TRAF2(3) 8030823 10 9 10 4 2 2 3 3 0 0 0.648 0.991 1.000 391 HSA00564_GLYCEROPHOSPHOLIPID_METABOLISM Genes involved in glycerophospholipid metabolism ACHE, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPAT6, ARD1A, CDIPT, CDS1, CDS2, CHAT, CHKA, CHKB, CHPT1, CRLS1, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKI, DGKQ, DGKZ, ESCO1, ESCO2, ETNK1, ETNK2, GNPAT, GPAM, GPD1, GPD1L, GPD2, LCAT, LYCAT, LYPLA1, LYPLA2, LYPLA3, MYST3, MYST4, NAT5, NAT6, PCYT1A, PCYT1B, PEMT, PHOSPHO1, PISD, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLD1, PLD2, PNPLA3, PPAP2A, PPAP2B, PPAP2C, PTDSS1, PTDSS2, SH3GLB1 64 ACHE(1), AGPAT2(1), AGPAT3(2), AGPAT4(1), AGPAT6(2), CHAT(2), DGKA(1), DGKB(1), DGKD(2), DGKH(1), DGKI(2), DGKQ(1), DGKZ(1), ESCO1(4), ETNK1(1), GNPAT(1), GPAM(2), NAT6(1), PLA2G12B(1), PLA2G2A(1), PLA2G4A(2), PLA2G6(1), PLD1(2), PPAP2A(1), PPAP2B(1) 25636154 36 30 36 6 8 2 3 10 13 0 0.0906 0.991 1.000 392 PHOTOSYNTHESIS ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, FDXR 22 ATP6V1A(2), ATP6V1B1(1), ATP6V1C2(3), ATP6V1F(1), ATP6V1H(1), FDXR(1), SHMT1(1) 6228507 10 10 10 4 2 1 0 5 2 0 0.870 0.992 1.000 393 FIBRINOLYSISPATHWAY Thrombin cleavage of fibrinogen results in rapid formation of fibrin threads that form a mesh to capture platelets and other blood cells into a clot. CPB2, F13A1, F2, F2R, FGA, FGB, FGG, PLAT, PLAU, PLG, SERPINB2, SERPINE1 12 CPB2(1), F13A1(1), F2(1), FGA(3), PLAT(2), PLAU(2), PLG(1), SERPINB2(1) 5213171 12 11 12 8 5 0 2 4 1 0 0.962 0.992 1.000 394 GLUCONEOGENESIS ACYP1, ACYP2, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AKR1A1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH9A1, ALDOA, ALDOB, ALDOC, BPGM, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, GAPDH, GCK, GPI, HK1, HK2, HK3, LDHA, LDHB, LDHC, PDHA1, PDHA2, PDHB, PFKM, PFKP, PGAM1, PGK1, PGM1, PGM3, PKLR, PKM2, TPI1 53 ADH1B(1), ADH4(1), ADH6(1), AKR1A1(1), ALDH1A1(1), ALDH1A2(3), ALDH1A3(1), ALDH3A1(1), ALDH3B1(1), ALDOC(1), ENO1(2), GCK(3), HK2(1), HK3(2), PDHA2(2), PFKM(1), PFKP(1), PGM1(1), PGM3(1) 19062981 26 24 25 6 9 0 4 9 4 0 0.218 0.993 1.000 395 GLYCOLYSIS ACYP1, ACYP2, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AKR1A1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH9A1, ALDOA, ALDOB, ALDOC, BPGM, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, GAPDH, GCK, GPI, HK1, HK2, HK3, LDHA, LDHB, LDHC, PDHA1, PDHA2, PDHB, PFKM, PFKP, PGAM1, PGK1, PGM1, PGM3, PKLR, PKM2, TPI1 53 ADH1B(1), ADH4(1), ADH6(1), AKR1A1(1), ALDH1A1(1), ALDH1A2(3), ALDH1A3(1), ALDH3A1(1), ALDH3B1(1), ALDOC(1), ENO1(2), GCK(3), HK2(1), HK3(2), PDHA2(2), PFKM(1), PFKP(1), PGM1(1), PGM3(1) 19062981 26 24 25 6 9 0 4 9 4 0 0.218 0.993 1.000 396 NUCLEOTIDE_METABOLISM ADSL, ADSS, DHFR, HPRT1, IMPDH1, MTHFD2, NME2, OAZ1, POLA, POLB, POLD1, POLG, PRPS2, RRM1, SAT, SRM 14 DHFR(1), POLD1(1), POLG(1) 4928437 3 3 3 5 1 1 0 0 1 0 0.994 0.993 1.000 397 ACTINYPATHWAY The Arp 2/3 complex localizes to the Y-junction of polymerizing actin fibers that enable lamellipod extension and consequent cell motility. ABI-2, ACTA1, ACTR2, ACTR3, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, NCK1, NCKAP1, NTRK1, PIR, PSMA7, RAC1, WASF1, WASF2, WASF3, WASL 18 ACTR3(1), NTRK1(3), RAC1(1), WASF2(1) 5936062 6 6 6 3 0 3 1 2 0 0 0.749 0.993 1.000 398 HSA01032_GLYCAN_STRUCTURES_DEGRADATION Genes involved in degradation of glycan structures AGA, ARSB, FLJ21865, FUCA1, FUCA2, GALNS, GBA, GLB1, GNS, GUSB, HEXA, HEXB, HGSNAT, HPSE, HPSE2, HYAL1, HYAL2, IDS, IDUA, LCT, MAN2B1, MAN2B2, MAN2C1, MANBA, NAGLU, NEU1, NEU2, NEU3, NEU4, SPAM1 29 AGA(2), ARSB(1), FUCA2(1), GALNS(2), HEXB(1), LCT(3), MAN2B2(1), MAN2C1(1), NEU1(1), NEU4(1), SPAM1(2) 13524408 16 12 16 4 8 1 1 3 3 0 0.386 0.993 1.000 399 TYROSINE_METABOLISM ABP1, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, AOX1, COMT, DBH, DCT, DDC, FAH, GOT1, GOT2, GSTZ1, HGD, HPD, MAOA, MAOB, PNMT, TAT, TH, TPO, TYR 32 ADH1B(1), ADH4(1), ADH6(1), ALDH1A3(1), ALDH3A1(1), ALDH3B1(1), AOC2(1), AOX1(1), DBH(3), FAH(1), GOT1(1), HGD(1), HPD(1), PNMT(1), TPO(1) 12366043 17 17 17 5 4 2 3 4 4 0 0.437 0.993 1.000 400 HSA01040_POLYUNSATURATED_FATTY_ACID_BIOSYNTHESIS Genes involved in polyunsaturated fatty acid biosynthesis ACAA1, ACOX1, ACOX3, ELOVL2, ELOVL5, ELOVL6, FADS1, FADS2, FASN, GPSN2, HADHA, HSD17B12, PECR, SCD 13 ACAA1(2), ACOX3(1), ELOVL6(1), FASN(1), SCD(1) 5673059 6 6 6 3 0 0 2 2 2 0 0.890 0.993 1.000 401 CELL_CYCLE_KEGG ABL1, ASK, ATM, BUB1, BUB1B, BUB3, CCNA1, CCNA2, CCNB1, CCNB2, CCNB3, CCND2, CCND3, CCNE1, CCNE2, CCNH, CDAN1, CDC14A, CDC14B, CDC14B, CDC14C, CDC2, CDC20, CDC25A, CDC25B, CDC25C, CDC45L, CDC6, CDC7, CDH1, CDK2, CDK4, CDKN1A, CDKN2A, CHEK1, CHEK2, DTX4, E2F1, E2F2, E2F3, E2F4, E2F5, E2F6, EP300, ESPL1, FLJ14001, GADD45A, GSK3B, HDAC1, HDAC2, HDAC3, HDAC4, HDAC5, HDAC6, HDAC7A, HDAC8, MAD1L1, MAD2L1, MAD2L2, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, MDM2, MPEG1, MPL, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, PLK1, PRKDC, PTPRA, PTTG1, PTTG2, PTTG3, RB1, RBL1, SKP2, SMAD4, SMC1L1, TBC1D8, TFDP1, TGFB1, TP53, WEE1 80 ABL1(4), BUB1(1), CCNA1(1), CCND3(1), CCNE2(1), CDC14B(2), CDC25A(1), CDC25B(2), CDC6(1), CDC7(1), CDH1(4), CDKN1A(2), CDKN2A(1), DTX4(1), E2F3(1), EP300(4), ESPL1(1), GSK3B(1), HDAC5(2), HDAC6(3), HDAC8(2), MAD1L1(1), MAD2L1(1), MAD2L2(1), MCM3(1), MCM4(2), MCM5(1), MCM6(2), MCM7(1), MDM2(1), MPEG1(5), PRKDC(7), PTPRA(3), RB1(2), SMAD4(4), TFDP1(1), TGFB1(1) 40064724 71 53 71 11 19 9 8 23 11 1 0.00779 0.993 1.000 402 MRPPATHWAY Cancer cells resistant to numerous drugs are called multidrug-resistant (MDR) and express ATP-binding cassette transporter proteins that pump the drugs out of cells. ABCB1, ABCB11, ABCB4, ABCC1, ABCC3, GSTP1 6 ABCB1(4), ABCC3(2) 5571866 6 6 6 4 2 1 1 1 1 0 0.909 0.994 1.000 403 EXTRINSICPATHWAY The extrinsic prothrombin activation pathway requires the release of thromboplastin from damaged tissues to activate the blood clotting cascade. F10, F2, F2R, F3, F5, F7, FGA, FGB, FGG, PROC, PROS1, SERPINC1, TFPI 13 F10(1), F2(1), F3(1), F5(3), F7(2), FGA(3), PROS1(2) 6375613 13 13 13 5 6 2 2 3 0 0 0.541 0.994 1.000 404 GLYCEROLIPID_METABOLISM ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AKR1A1, AKR1B1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, CEL, DGAT1, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKQ, DGKZ, GK, GLA, GLB1, LCT, LIPC, LIPF, LIPG, LPL, PNLIP, PNLIPRP1, PNLIPRP2, PPAP2A, PPAP2B, PPAP2C 45 ADH1B(1), ADH4(1), ADH6(1), AGPAT2(1), AGPAT3(2), AGPAT4(1), AKR1A1(1), ALDH1A1(1), ALDH1A2(3), ALDH1A3(1), ALDH3A1(1), DGAT1(1), DGKA(1), DGKB(1), DGKD(2), DGKH(1), DGKQ(1), DGKZ(1), GK(1), LCT(3), LIPG(3), PNLIP(1), PPAP2A(1), PPAP2B(1) 18874271 32 25 31 7 10 3 4 9 6 0 0.141 0.994 1.000 405 GLUTATHIONE_METABOLISM ANPEP, G6PD, GCLC, GCLM, GGT1, GPX1, GPX2, GPX3, GPX4, GPX5, GSS, GSTA1, GSTA2, GSTA3, GSTA4, GSTM1, GSTM2, GSTM3, GSTM4, GSTM5, GSTO2, GSTP1, GSTT1, GSTT2, GSTZ1, IDH1, IDH2, MGST1, MGST2, MGST3, PGD 29 GPX4(1), GSTA2(1), GSTM2(1), GSTM5(2), GSTO2(1) 6733854 6 6 6 3 2 0 1 3 0 0 0.839 0.995 1.000 406 S1PPATHWAY At low cholesterol concentrations, sterol-regulatory element binding proteins (SREBPs) act as transcription factors to promote cholesterol uptake and biosynthesis. EPLIN, HMGCS1, LDLR, MBTPS1, MBTPS2, SCAP, SREBF1, SREBF2 7 LDLR(1), MBTPS2(1), SCAP(1), SREBF2(1) 4717051 4 4 4 4 1 0 0 2 1 0 0.984 0.995 1.000 407 SA_CASPASE_CASCADE Apoptosis is mediated by caspases, cysteine proteases arranged in a proteolytic cascade. ADPRT, APAF1, BIRC2, BIRC3, BIRC4, CASP10, CASP3, CASP7, CASP8, CASP9, DFFA, DFFB, GZMB, PRF1, SCAP, SREBF1, SREBF2, TNFRSF6, TNFSF6 15 APAF1(1), BIRC2(1), DFFA(1), PRF1(1), SCAP(1), SREBF2(1) 7189238 6 6 6 3 0 2 0 3 1 0 0.845 0.996 1.000 408 HSA00860_PORPHYRIN_AND_CHLOROPHYLL_METABOLISM Genes involved in porphyrin and chlorophyll metabolism ALAD, ALAS1, ALAS2, BLVRA, BLVRB, COX10, COX15, CP, CPOX, EARS2, EPRS, FECH, FTH1, FTMT, GUSB, HCCS, HMBS, HMOX1, HMOX2, MMAB, PPOX, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, UROD, UROS 41 BLVRB(1), COX15(1), CP(2), CPOX(1), EPRS(2), HMBS(1), HMOX2(1), MMAB(1), UGT1A4(1), UGT1A7(1), UGT1A8(2), UGT1A9(1), UGT2A1(1), UGT2A3(1), UGT2B10(2), UGT2B11(2), UGT2B15(1), UGT2B17(1), UGT2B28(2), UGT2B7(1) 16429831 26 22 26 6 8 1 2 10 5 0 0.365 0.996 1.000 409 BIOGENIC_AMINE_SYNTHESIS AANAT, ACHE, CHAT, COMT, DBH, DDC, DXYS155E, GAD1, GAD2, HDC, MAOA, PAH, PNMT, SLC18A3, TH, TPH1 15 ACHE(1), CHAT(2), DBH(3), GAD2(4), PAH(1), PNMT(1), TPH1(1) 5661082 13 13 13 6 5 2 1 3 2 0 0.650 0.996 1.000 410 HSA00480_GLUTATHIONE_METABOLISM Genes involved in glutathione metabolism ANPEP, G6PD, GCLC, GCLM, GGT1, GGTL3, GGTL4, GPX1, GPX2, GPX3, GPX4, GPX5, GPX6, GPX7, GSR, GSS, GSTA1, GSTA2, GSTA3, GSTA4, GSTA5, GSTK1, GSTM1, GSTM2, GSTM3, GSTM4, GSTM5, GSTO2, GSTP1, GSTT1, GSTT2, GSTZ1, IDH1, IDH2, MGST1, MGST2, MGST3, OPLAH, TXNDC12 35 GPX4(1), GSTA2(1), GSTM2(1), GSTM5(2), GSTO2(1), OPLAH(1) 8304702 7 7 7 3 2 0 1 3 1 0 0.755 0.996 1.000 411 DREAMPATHWAY The transcription factor DREAM blocks expression of the prodynorphin gene, which encodes the ligand of an opioid receptor that blocks pain signaling. CREB1, CREM, CSEN, FOS, JUN, MAPK3, OPRK1, POLR2A, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B 13 CREM(1), POLR2A(2), PRKAR1A(1), PRKAR1B(1) 5037547 5 4 5 3 3 0 0 2 0 0 0.832 0.996 1.000 412 SHHPATHWAY Sonic hedgehog (Shh) signaling in the developing CNS induces neuronal proliferation via interaction with the patched (Ptc-1) and smoothened receptors. DYRK1A, DYRK1B, GLI, GLI2, GLI3, GSK3B, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTCH, SHH, SMO, SUFU 14 DYRK1A(2), DYRK1B(2), GLI2(3), GLI3(1), GSK3B(1), PRKAR1A(1), PRKAR1B(1), SHH(2), SUFU(1) 6528670 14 12 14 6 3 1 1 6 3 0 0.759 0.996 1.000 413 ST_JAK_STAT_PATHWAY The Janus kinase-signal transducer and activator of transcription (JAK-STAT) pathway transduces extracellular signals to promote gene activation. CISH, JAK1, JAK2, JAK3, PIAS1, PIAS3, PTPRU, REG1A, SOAT1 9 JAK1(3), PIAS3(1), PTPRU(2) 5385242 6 5 6 4 1 1 1 2 1 0 0.927 0.996 1.000 414 IL1RPATHWAY The cytokine IL-1 stimulates its primary receptor, IL-1R1, which induces transcription of inflammation-related genes such as interferons. CHUK, IFNA1, IFNB1, IKBKB, IL1A, IL1B, IL1R1, IL1RAP, IL1RN, IL6, IRAK1, IRAK2, IRAK3, JUN, MAP2K3, MAP2K6, MAP3K1, MAP3K14, MAP3K7, MAP3K7IP1, MAPK14, MAPK8, MYD88, NFKB1, NFKBIA, RELA, SITPEC, TGFB1, TGFB2, TGFB3, TNF, TOLLIP, TRAF6 31 IL1RAP(2), IL6(1), IRAK1(1), IRAK2(2), MAP3K7(2), RELA(2), TGFB1(1), TGFB2(1), TNF(1) 11577058 13 12 13 4 6 2 2 1 2 0 0.422 0.996 1.000 415 VEGFPATHWAY Vascular endothelial growth factor (VEGF) is upregulated by hypoxic conditions and promotes normal blood vessel formation and angiogenesis related to tumor growth or cardiac disease. ARNT, EIF1, EIF1A, EIF2B1, EIF2B2, EIF2B3, EIF2B4, EIF2B5, EIF2S1, EIF2S2, EIF2S3, ELAVL1, FLT1, FLT4, HIF1A, HRAS, KDR, NOS3, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, PTK2, PXN, SHC1, VEGF, VHL 25 ARNT(2), EIF2B2(1), EIF2B3(1), FLT1(2), FLT4(2), HRAS(3), KDR(3), NOS3(1), PIK3CA(10), PIK3R1(1), PLCG1(1), PRKCA(2), PTK2(2), PXN(1), SHC1(2), VHL(1) 13283287 35 26 35 9 17 4 3 6 5 0 0.260 0.996 1.000 416 PHENYLALANINE_METABOLISM ABP1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, DDC, EPX, GOT1, GOT2, HPD, LPO, MAOA, MAOB, MPO, PRDX1, PRDX2, PRDX5, PRDX6, TAT, TPO 22 ALDH1A3(1), ALDH3A1(1), ALDH3B1(1), AOC2(1), EPX(1), GOT1(1), HPD(1), LPO(1), TPO(1) 8569332 9 9 9 4 2 2 1 3 1 0 0.798 0.996 1.000 417 HSA04664_FC_EPSILON_RI_SIGNALING_PATHWAY Genes involved in Fc epsilon RI signaling pathway AKT1, AKT2, AKT3, BTK, CSF2, FCER1A, FCER1G, FYN, GAB2, GRB2, HRAS, IL13, IL3, IL4, IL5, INPP5D, KRAS, LAT, LCP2, LYN, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK8, MAPK9, MS4A2, NRAS, PDK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCG1, PLCG2, PRKCA, PRKCB1, PRKCD, PRKCE, RAC1, RAC2, RAC3, RAF1, SOS1, SOS2, SYK, TNF, VAV1, VAV2, VAV3 74 AKT1(1), AKT2(1), BTK(1), FCER1A(1), GAB2(5), GRB2(1), HRAS(3), IL4(1), INPP5D(2), MAP2K4(1), MAP2K7(2), MAPK1(1), PDK1(1), PIK3CA(10), PIK3CB(1), PIK3CG(3), PIK3R1(1), PIK3R2(2), PIK3R3(1), PLA2G12B(1), PLA2G2A(1), PLA2G4A(2), PLA2G6(1), PLCG1(1), PLCG2(1), PRKCA(2), RAC1(1), RAC2(1), RAF1(1), SOS1(1), SYK(2), TNF(1), VAV1(3), VAV2(1), VAV3(1) 28229584 60 51 60 13 22 7 8 19 4 0 0.0593 0.996 1.000 418 ATRBRCAPATHWAY BRCA1 and 2 block cell cycle progression in response to DNA damage and promote double-stranded break repair; mutations induce breast cancer susceptibility. ATM, ATR, BRCA1, BRCA2, CHEK1, CHEK2, FANCA, FANCC, FANCD2, FANCE, FANCF, FANCG, HUS1, MRE11A, NBS1, RAD1, RAD17, RAD50, RAD51, RAD9A, TP53, TREX1 19 BRCA2(5), FANCA(2), FANCG(1), HUS1(1), RAD17(1), RAD51(1) 14390483 11 11 11 3 0 0 1 5 5 0 0.862 0.997 1.000 419 HSA03320_PPAR_SIGNALING_PATHWAY Genes involved in PPAR signaling pathway ACAA1, ACADL, ACADM, ACOX1, ACOX2, ACOX3, ACSL1, ACSL3, ACSL4, ACSL5, ACSL6, ADIPOQ, ANGPTL4, APOA1, APOA2, APOA5, APOC3, AQP7, CD36, CPT1A, CPT1B, CPT1C, CPT2, CYP27A1, CYP4A11, CYP4A22, CYP7A1, CYP8B1, DBI, EHHADH, FABP1, FABP2, FABP3, FABP4, FABP5, FABP5L1, FABP6, FABP7, FADS2, GK, GK2, HMGCS2, ILK, LOC642956, LPL, ME1, MMP1, NR1H3, OLR1, PCK1, PCK2, PDPK1, PLIN, PLTP, PPARA, PPARD, PPARG, RXRA, RXRB, RXRG, SCD, SCP2, SLC27A1, SLC27A2, SLC27A4, SLC27A5, SLC27A6, SORBS1, UBC, UCP1 67 ACAA1(2), ACOX3(1), ACSL1(1), ACSL6(2), AQP7(1), CPT1C(3), CYP7A1(1), EHHADH(2), FABP2(1), FABP4(1), GK(1), HMGCS2(1), ME1(2), PCK2(2), PDPK1(1), PLTP(1), PPARA(2), PPARD(1), PPARG(1), RXRB(2), RXRG(1), SCD(1), SLC27A1(1), SLC27A4(1), SLC27A6(1), SORBS1(2), UBC(1) 25555322 37 29 37 7 13 6 5 5 8 0 0.0569 0.997 1.000 420 RHOPATHWAY RhoA is a G protein whose active form stabilizes actin structures such as focal adhesions and activates Rock1, which phosphorylates myosin light chains. ACTR2, ACTR3, ARHA, ARHGAP1, ARHGAP4, ARHGAP5, ARHGAP6, ARHGEF1, ARHGEF11, ARHGEF5, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, BAIAP2, CFL1, DIAPH1, GSN, LIMK1, MYL2, MYLK, OPHN1, PFN1, PIP5K1A, PIP5K1B, PPP1R12B, ROCK1, SRC, TLN1, VCL 30 ACTR3(1), ARHGAP6(1), ARHGEF1(3), ARHGEF11(2), ARHGEF5(2), CFL1(1), DIAPH1(1), GSN(1), LIMK1(1), MYLK(3), PFN1(1), ROCK1(5), TLN1(2) 17621517 24 22 23 6 3 2 4 6 9 0 0.545 0.997 1.000 421 EPOPATHWAY Erythropoietin, which activates the MAPK pathway, stimulates erythrocyte production and is an effective treatment for anemia. CSNK2A1, ELK1, EPO, EPOR, FOS, GRB2, HRAS, JAK2, JUN, MAP2K1, MAPK3, MAPK8, PLCG1, PTPN6, RAF1, SHC1, SOS1, STAT5A, STAT5B 19 GRB2(1), HRAS(3), PLCG1(1), RAF1(1), SHC1(2), SOS1(1), STAT5B(1) 8353782 10 10 10 4 6 2 2 0 0 0 0.609 0.997 1.000 422 NOS1PATHWAY Glutamate stimulates NMDA-mediates calcium influx, which promotes nitric oxide synthesis from arginine by neuronal nitric oxide synthase, activating guanylate cyclase. CALM1, CALM2, CALM3, DLG4, GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D, NOS1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, SYT1 21 GRIN1(1), GRIN2A(6), GRIN2B(3), GRIN2C(1), NOS1(2), PPP3CA(1), PPP3CC(1), PRKAR1A(1), PRKAR1B(1), PRKCA(2), SYT1(1) 10021124 20 19 20 8 6 3 0 9 2 0 0.670 0.997 1.000 423 GALACTOSE_METABOLISM AKR1B1, B4GALT1, B4GALT2, FBP2, G6PC, GAA, GALE, GALK1, GALK2, GALT, GANAB, GCK, GLA, GLB1, HK1, HK2, HK3, LALBA, LCT, MGAM, PFKM, PFKP, PGM1, PGM3 24 B4GALT1(2), B4GALT2(1), GAA(1), GALK1(1), GALK2(1), GANAB(1), GCK(3), HK2(1), HK3(2), LCT(3), MGAM(2), PFKM(1), PFKP(1), PGM1(1), PGM3(1) 12759908 22 19 22 6 11 1 2 5 3 0 0.285 0.997 1.000 424 TOLLPATHWAY Toll-like receptors are activated by bacterial lipoproteins, lipopolysaccharides, and other surface molecules, and activate pro-inflammatory factors such as NF-kB. CD14, CHUK, ELK1, FOS, IKBKB, IKBKG, IRAK1, JUN, LY96, MAP2K3, MAP2K4, MAP2K6, MAP3K1, MAP3K14, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAPK14, MAPK8, MYD88, NFKB1, NFKBIA, PGLYRP, PPARA, PRKR, RELA, SITPEC, TIRAP, TLR10, TLR2, TLR3, TLR4, TLR6, TLR7, TLR9, TOLLIP, TRAF6 31 IRAK1(1), MAP2K4(1), MAP3K7(2), PPARA(2), RELA(2), TLR10(1), TLR7(1), TLR9(1) 14207939 11 8 11 2 7 1 1 1 1 0 0.223 0.997 1.000 425 SIG_PIP3_SIGNALING_IN_CARDIAC_MYOCTES Genes related to PIP3 signaling in cardiac myocytes AKT1, AKT2, AKT3, BAD, BCL2L1, CDC42, CDK2, CDKN1B, CDKN2A, CREB1, CREB3, CREB5, EBP, ERBB4, F2RL2, FOXO3A, FRAP1, GAB1, GADD45A, GRB2, GSK3A, GSK3B, IFI27, IGF1, IGFBP1, INPPL1, IRS1, IRS2, IRS4, MET, MYC, NOLC1, P101-PI3K, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PARD3, PARD6A, PDK1, PIK3CA, PIK3CD, PPP1R13B, PREX1, PSCD3, PTEN, PTK2, PTPN1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SFN, SHC1, SLC2A4, SOS1, SOS2, TSC1, TSC2, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ 62 AKT1(1), AKT2(1), CDKN1B(4), CDKN2A(1), CREB3(1), EBP(1), ERBB4(1), GRB2(1), GSK3A(2), GSK3B(1), IRS1(2), IRS2(1), IRS4(3), MET(1), PAK2(1), PDK1(1), PIK3CA(10), PPP1R13B(1), PTK2(2), PTPN1(1), RPS6KA1(1), SHC1(2), SOS1(1), TSC2(2), YWHAH(1), YWHAQ(1) 29941163 45 35 45 9 9 8 3 10 15 0 0.179 0.998 1.000 426 TNFR1PATHWAY Tumor necrosis factor alpha binds to its receptor TNFR1 and induces caspase-dependent apoptosis. ADPRT, ARHGDIB, BAG4, CASP2, CASP3, CASP8, CRADD, DFFA, DFFB, FADD, JUN, LMNA, LMNB1, LMNB2, MADD, MAP2K4, MAP3K1, MAP3K7, MAPK8, PAK1, PAK2, PRKDC, RB1, RIPK1, SPTAN1, TNF, TNFRSF1A, TRADD, TRAF2 28 ARHGDIB(1), DFFA(1), LMNA(2), MADD(2), MAP2K4(1), MAP3K7(2), PAK2(1), PRKDC(7), RB1(2), RIPK1(1), TNF(1), TRAF2(3) 15134869 24 21 24 6 9 3 2 6 3 1 0.299 0.998 1.000 427 O_GLYCAN_BIOSYNTHESIS GALNT1, GALNT10, GALNT2, GALNT3, GALNT4, GALNT6, GALNT7, GALNT8, GALNT9, GCNT1, SIAT4A, SIAT4B, ST3GAL1, ST3GAL2, ST3GAL4, WBSCR17 14 GALNT10(2), GALNT3(2), GALNT8(1), ST3GAL1(2), WBSCR17(1) 5617542 8 8 8 4 5 1 0 2 0 0 0.774 0.998 1.000 428 ALKPATHWAY Activin receptor-like kinase 3 (ALK3) is required during gestation for cardiac muscle development. ACVR1, APC, ATF2, AXIN1, BMP10, BMP2, BMP4, BMP5, BMP7, BMPR1A, BMPR2, CHRD, CTNNB1, DVL1, FZD1, GATA4, GSK3B, MADH1, MADH4, MADH5, MADH6, MAP3K7, MEF2C, MYL2, NKX2-5, NOG, NPPA, NPPB, RFC1, TCF1, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TGFBR3, WNT1 31 APC(2), ATF2(1), BMP5(2), BMP7(3), BMPR2(1), CHRD(1), FZD1(2), GSK3B(1), MAP3K7(2), MEF2C(2), NPPA(1), RFC1(1), TGFB1(1), TGFB2(1), TGFBR1(2), TGFBR3(1) 13618821 24 18 24 7 7 3 6 4 4 0 0.340 0.998 1.000 429 HSA00100_BIOSYNTHESIS_OF_STEROIDS Genes involved in biosynthesis of steroids CYP27B1, CYP51A1, DHCR24, DHCR7, EBP, FDFT1, FDPS, GGCX, GGPS1, HMGCR, HSD17B7, IDI1, IDI2, LSS, MVD, MVK, NQO1, NSDHL, PMVK, SC4MOL, SC5DL, SQLE, TM7SF2, VKORC1 24 CYP27B1(3), EBP(1), GGCX(1), NQO1(1), SQLE(1), TM7SF2(1) 7532144 8 8 8 5 4 1 1 0 2 0 0.886 0.998 1.000 430 HSA00052_GALACTOSE_METABOLISM Genes involved in galactose metabolism AKR1B1, AKR1B10, B4GALT1, B4GALT2, G6PC, G6PC2, GAA, GALE, GALK1, GALK2, GALT, GANC, GCK, GLA, GLB1, HK1, HK2, HK3, HSD3B7, LALBA, LCT, MGAM, PFKL, PFKM, PFKP, PGM1, PGM3, RDH11, RDH12, RDH13, RDH14, UGP2 32 B4GALT1(2), B4GALT2(1), GAA(1), GALK1(1), GALK2(1), GANC(2), GCK(3), HK2(1), HK3(2), LCT(3), MGAM(2), PFKL(1), PFKM(1), PFKP(1), PGM1(1), PGM3(1), RDH12(1), UGP2(1) 15157079 26 22 26 7 12 1 2 7 4 0 0.233 0.998 1.000 431 LAIRPATHWAY The local acute inflammatory response is mediated by activated macrophages and mast cells or by complement activation. BDK, C3, C5, C6, C7, ICAM1, IL1A, IL6, IL8, ITGA4, ITGAL, ITGB1, ITGB2, SELP, SELPLG, TNF, VCAM1 16 C3(1), C6(2), IL6(1), ITGAL(3), ITGB2(2), SELP(2), SELPLG(1), TNF(1), VCAM1(1) 9649091 14 12 14 5 6 3 1 3 1 0 0.396 0.998 1.000 432 HSA00563_GLYCOSYLPHOSPHATIDYLINOSITOL_ANCHOR_BIOSYNTHESIS Genes involved in glycosylphosphatidylinositol(GPI)-anchor biosynthesis GPAA1, GPLD1, PGAP1, PIGA, PIGB, PIGC, PIGF, PIGG, PIGH, PIGK, PIGL, PIGM, PIGN, PIGO, PIGP, PIGQ, PIGS, PIGT, PIGU, PIGV, PIGW, PIGX, PIGZ 23 GPLD1(1), PIGA(1), PIGB(2), PIGO(1), PIGQ(3) 9302115 8 7 8 3 2 1 2 1 2 0 0.714 0.998 1.000 433 IL7PATHWAY IL-7 is required for B and T cell development and proliferation and may contribute to activation of VDJ recombination. BCL2, CREBBP, EP300, FYN, IL2RG, IL7, IL7R, JAK1, JAK3, LCK, NMI, PIK3CA, PIK3R1, PTK2B, STAT5A, STAT5B 16 CREBBP(4), EP300(4), IL7(1), IL7R(1), JAK1(3), PIK3CA(10), PIK3R1(1), STAT5B(1) 10914795 25 21 25 9 7 4 3 9 2 0 0.703 0.998 1.000 434 ST_MYOCYTE_AD_PATHWAY Cardiac myocytes have a variety of adrenergic receptors that induce subtype-specific signaling effects. ADRB1, AKT1, APC, ASAH1, BF, CAMP, CAV3, DAG1, DLG4, EPHB2, GAS, GNAI1, GNAQ, HTATIP, ITPR1, ITPR2, ITPR3, KCNJ3, KCNJ5, KCNJ9, MAPK1, PITX2, PLB, PTX1, PTX3, RAC1, RHO, RYR1 23 ADRB1(1), AKT1(1), APC(2), ASAH1(1), CAV3(1), DAG1(1), EPHB2(3), GNAI1(1), ITPR1(2), ITPR2(3), ITPR3(1), KCNJ5(1), MAPK1(1), PITX2(1), RAC1(1), RYR1(8) 17943249 29 26 29 9 14 2 2 4 7 0 0.459 0.999 1.000 435 GPCRDB_CLASS_C_METABOTROPIC_GLUTAMATE_PHEROMONE CASR, GABBR1, GPCR5A, GPR51, GPRC5A, GPRC5B, GPRC5C, GPRC5D, GRM1, GRM2, GRM3, GRM4, GRM5, GRM7, GRM8 13 CASR(1), GPRC5B(1), GRM1(2), GRM3(1), GRM4(1), GRM5(3), GRM7(1), GRM8(1) 8177456 11 11 10 5 5 1 1 2 2 0 0.589 0.999 1.000 436 PS1PATHWAY Presenilin is required for gamma-secretase activity to activate Notch signaling; presenilin also inhibits beta-catenin in the Wnt/Frizzled pathway. ADAM17, APC, AXIN1, BTRC, CTNNB1, DLL1, DVL1, FZD1, GSK3B, NOTCH1, PSEN1, RBPSUH, TCF1, WNT1 11 APC(2), FZD1(2), GSK3B(1), NOTCH1(2) 7862196 7 7 7 4 2 1 2 0 2 0 0.753 0.999 1.000 437 HSA00190_OXIDATIVE_PHOSPHORYLATION Genes involved in oxidative phosphorylation ATP12A, ATP4A, ATP4B, ATP5A1, ATP5B, ATP5C1, ATP5D, ATP5E, ATP5F1, ATP5G1, ATP5G2, ATP5G3, ATP5H, ATP5I, ATP5J, ATP5J2, ATP5L, ATP5O, ATP6, ATP6AP1, ATP6V0A1, ATP6V0A2, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0D1, ATP6V0D2, ATP6V0E1, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1E2, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, ATP8, COX1, COX10, COX15, COX17, COX2, COX3, COX4I1, COX4I2, COX5A, COX5B, COX6A1, COX6A2, COX6B1, COX6B2, COX6C, COX7A1, COX7A2, COX7B, COX7B2, COX7C, COX8A, COX8C, CYC1, CYTB, LHPP, ND1, ND2, ND3, ND4, ND4L, ND5, ND6, NDUFA1, NDUFA10, NDUFA11, NDUFA12, NDUFA13, NDUFA2, NDUFA3, NDUFA4, NDUFA4L2, NDUFA5, NDUFA6, NDUFA7, NDUFA8, NDUFA9, NDUFAB1, NDUFB1, NDUFB10, NDUFB11, NDUFB2, NDUFB3, NDUFB4, NDUFB5, NDUFB6, NDUFB7, NDUFB8, NDUFB9, NDUFC1, NDUFC2, NDUFS1, NDUFS2, NDUFS3, NDUFS4, NDUFS5, NDUFS6, NDUFS7, NDUFS8, NDUFV1, NDUFV2, NDUFV3, PPA1, PPA2, SDHA, SDHB, SDHC, SDHD, TCIRG1, UCRC, UQCR, UQCRB, UQCRC1, UQCRC2, UQCRFS1, UQCRH, UQCRQ 113 ATP12A(1), ATP5A1(2), ATP6V0A2(3), ATP6V1A(2), ATP6V1B1(1), ATP6V1C2(3), ATP6V1E2(1), ATP6V1F(1), ATP6V1H(1), COX15(1), CYC1(1), NDUFA10(2), NDUFB10(2), NDUFB7(1), NDUFS3(1), NDUFV1(1), SDHA(1), SDHC(1), UQCRC1(1) 21823261 27 24 27 6 3 4 4 11 5 0 0.330 0.999 1.000 438 NITROGEN_METABOLISM AMT, ASNS, CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA8, CA9, CPS1, CTH, GLS, GLS2, GLUD1, GLUL, HAL 21 AMT(1), CA1(1), CA14(1), CA2(1), CA3(1), CA6(1), CA8(2), CA9(1), CTH(1), HAL(1) 7397661 11 10 11 7 3 3 0 4 1 0 0.928 0.999 1.000 439 HSA04740_OLFACTORY_TRANSDUCTION Genes involved in olfactory transduction ADCY3, ADRBK2, ARRB2, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CLCA1, CLCA2, CLCA4, CNGA3, CNGA4, CNGB1, GNAL, GUCA1A, GUCA1B, GUCA1C, PDC, PDE1C, PRKACA, PRKACB, PRKACG, PRKG1, PRKG2, PRKX, PRKY 30 ADCY3(1), CALML6(1), CAMK2A(1), CAMK2D(1), CLCA1(1), CLCA2(1), CNGA3(1), CNGA4(3), GNAL(1), PDE1C(1), PRKACA(1), PRKG1(1), PRKX(2) 11906939 16 16 16 8 3 3 2 4 4 0 0.748 0.999 1.000 440 STARCH_AND_SUCROSE_METABOLISM AGL, AMY1A, AMY1B, AMY1C, AMY2A, AMY2B, AMY2B, RNPC3, ENPP1, ENPP3, G6PC, GAA, GANAB, GBA3, GBE1, GCK, GPI, GUSB, GYS1, GYS2, HK1, HK2, HK3, MGAM, PGM1, PGM3, PYGB, PYGL, PYGM, SI, UCHL1, UCHL3, UGDH, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4, UXS1 41 AGL(2), AMY2B(2), ENPP1(2), ENPP3(1), GAA(1), GANAB(1), GBE1(2), GCK(3), HK2(1), HK3(2), MGAM(2), PGM1(1), PGM3(1), PYGL(2), SI(1), UGDH(1), UGT1A4(1), UGT1A7(1), UGT1A8(2), UGT1A9(1), UGT2B15(1) 22219893 31 29 31 8 8 4 5 6 8 0 0.293 0.999 1.000 441 N_GLYCAN_BIOSYNTHESIS ALG3, ALG5, B4GALT1, B4GALT2, B4GALT3, B4GALT5, DDOST, DPAGT1, DPM1, FUT8, GCS1, MAN1A1, MAN1B1, MGAT1, MGAT2, MGAT3, MGAT4A, MGAT4B, MGAT5, RPN1, RPN2, ST6GAL1 21 B4GALT1(2), B4GALT2(1), MAN1A1(2), MGAT5(1), RPN1(1), ST6GAL1(1) 7808124 8 7 8 3 5 1 0 2 0 0 0.668 0.999 1.000 442 BETA_ALANINE_METABOLISM ABAT, ABP1, ACADL, ACADM, ACADSB, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, AOC2, AOC3, CNDP1, DPYD, DPYS, ECHS1, EHHADH, GAD1, GAD2, HADHA, MLYCD, SDS, SMS, UPB1 27 ACADSB(2), ALDH1A1(1), ALDH1A2(3), ALDH1A3(1), ALDH3A1(1), AOC2(1), CNDP1(2), DPYD(2), DPYS(1), EHHADH(2), GAD2(4) 11338215 20 18 19 7 5 4 3 6 2 0 0.452 0.999 1.000 443 VIPPATHWAY Apoptosis of activated T cells is inhibited by vasoactive intestinal peptide (VIP) and its relative PACAP. CALM1, CALM2, CALM3, CHUK, EGR2, EGR3, GNAQ, MAP3K1, MYC, NFATC1, NFATC2, NFKB1, NFKBIA, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RELA, SYT1, VIP, VIPR2 27 EGR3(1), NFATC1(1), NFATC2(1), PLCG1(1), PPP3CA(1), PPP3CC(1), PRKAR1A(1), PRKAR1B(1), RELA(2), SYT1(1) 10921944 11 10 11 4 2 1 2 5 1 0 0.644 0.999 1.000 444 HSA04730_LONG_TERM_DEPRESSION Genes involved in long-term depression ARAF, BRAF, C7orf16, CACNA1A, CRH, CRHR1, GNA11, GNA12, GNA13, GNAI1, GNAI2, GNAI3, GNAO1, GNAQ, GNAS, GNAZ, GRIA1, GRIA2, GRIA3, GRID2, GRM1, GRM5, GUCY1A2, GUCY1A3, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, HRAS, IGF1, IGF1R, ITPR1, ITPR2, ITPR3, KRAS, LYN, MAP2K1, MAP2K2, MAPK1, MAPK3, NOS1, NOS2A, NOS3, NPR1, NPR2, NRAS, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCB1, PLCB2, PLCB3, PLCB4, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, PRKCA, PRKCB1, PRKCG, PRKG1, PRKG2, RAF1, RYR1 73 ARAF(1), CACNA1A(8), GNA13(1), GNAI1(1), GNAI2(1), GNAO1(1), GNAS(2), GNAZ(1), GRIA1(4), GRIA2(2), GRIA3(1), GRID2(5), GRM1(2), GRM5(3), GUCY1A2(2), GUCY1A3(1), GUCY2C(2), GUCY2F(3), HRAS(3), IGF1R(1), ITPR1(2), ITPR2(3), ITPR3(1), MAPK1(1), NOS1(2), NOS3(1), PLA2G12B(1), PLA2G2A(1), PLA2G4A(2), PLA2G6(1), PLCB1(2), PLCB4(3), PPP2R1B(1), PPP2R2B(3), PPP2R2C(1), PRKCA(2), PRKCG(1), PRKG1(1), RAF1(1), RYR1(8) 42526490 83 67 82 16 37 7 7 18 14 0 0.0111 0.999 1.000 445 UCALPAINPATHWAY Calpains promote formation of integrin adhesion clusters which recruit Rac to enable the formation of mature focal adhesions that do not contain calpain. ACTA1, ACTN1, ACTN2, ACTN3, ARHA, CAPN1, CAPNS1, CAPNS2, ITGA1, ITGB1, ITGB3, PTK2, PXN, RAC1, SPTAN1, SRC, TLN1, VIL2 16 CAPNS1(1), PTK2(2), PXN(1), RAC1(1), TLN1(2) 11165871 7 7 7 2 2 1 1 2 1 0 0.514 0.999 1.000 446 HSA00650_BUTANOATE_METABOLISM Genes involved in butanoate metabolism AACS, AADAC, ABAT, ACADS, ACAT1, ACAT2, ACSM1, AKR1B10, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH5A1, ALDH7A1, ALDH9A1, BDH1, BDH2, DDHD1, ECHS1, EHHADH, GAD1, GAD2, HADH, HADHA, HMGCL, HMGCS1, HMGCS2, HSD17B10, HSD17B4, HSD3B7, ILVBL, L2HGDH, OXCT1, OXCT2, PDHA1, PDHA2, PDHB, PLA1A, PPME1, PRDX6, RDH11, RDH12, RDH13, RDH14 45 AADAC(1), ACADS(2), ACAT1(1), ALDH1A3(1), ALDH3A1(1), ALDH5A1(1), DDHD1(3), EHHADH(2), GAD2(4), HADH(1), HMGCS2(1), HSD17B4(1), ILVBL(2), PDHA2(2), RDH12(1) 15852924 24 22 23 7 8 3 3 6 4 0 0.315 0.999 1.000 447 HSA00280_VALINE_LEUCINE_AND_ISOLEUCINE_DEGRADATION Genes involved in valine, leucine and isoleucine degradation ABAT, ACAA1, ACAA2, ACADM, ACADS, ACAT1, ACAT2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH7A1, ALDH9A1, AOX1, AUH, BCAT1, BCAT2, BCKDHA, BCKDHB, DBT, DLD, ECHS1, EHHADH, HADH, HADHA, HADHB, HIBADH, HIBCH, HMGCL, HMGCS1, HMGCS2, HSD17B10, HSD17B4, IVD, MCCC1, MCCC2, MCEE, MUT, OXCT1, OXCT2, PCCA, PCCB 44 ACAA1(2), ACAA2(1), ACADS(2), ACAT1(1), ALDH1A3(1), ALDH3A1(1), AOX1(1), BCAT1(1), BCKDHA(1), EHHADH(2), HADH(1), HADHB(1), HMGCS2(1), HSD17B4(1), IVD(1), MUT(1) 16771232 19 19 18 5 6 3 2 5 3 0 0.346 0.999 1.000 448 ALANINE_AND_ASPARTATE_METABOLISM AARS, ABAT, ADSL, ADSS, AGXT, AGXT2, ASL, ASNS, ASPA, ASS, CAD, CRAT, DARS, DDO, GAD1, GAD2, GOT1, GOT2, GPT, GPT2, NARS, PC 21 AARS(1), AGXT(1), CAD(1), GAD2(4), GOT1(1), PC(1) 10177769 9 9 9 5 2 1 0 3 3 0 0.898 0.999 1.000 449 HSA00260_GLYCINE_SERINE_AND_THREONINE_METABOLISM Genes involved in glycine, serine and threonine metabolism ABP1, AGXT, AGXT2, AKR1B10, ALAS1, ALAS2, AMT, AOC2, AOC3, BHMT, CBS, CHDH, CHKA, CHKB, CTH, DAO, DLD, DMGDH, GAMT, GARS, GATM, GCAT, GLDC, GNMT, HSD3B7, MAOA, MAOB, PEMT, PHGDH, PIPOX, PISD, PSAT1, PSPH, RDH11, RDH12, RDH13, RDH14, SARDH, SARS, SARS2, SDS, SHMT1, SHMT2, TARS, TARS2 45 AGXT(1), AMT(1), AOC2(1), CBS(1), CHDH(2), CTH(1), DAO(1), GARS(1), GCAT(1), GLDC(2), RDH12(1), SARDH(3), SARS(1), SHMT1(1), SHMT2(1), TARS(1), TARS2(1) 16693664 21 19 21 6 8 2 0 5 6 0 0.638 0.999 1.000 450 HSA00561_GLYCEROLIPID_METABOLISM Genes involved in glycerolipid metabolism ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AGK, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPAT6, AKR1A1, AKR1B1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, CEL, DAK, DGAT1, DGAT2, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKI, DGKQ, DGKZ, GK, GK2, GLA, GLB1, GPAM, LCT, LIPA, LIPC, LIPF, LIPG, LPL, LYCAT, MGLL, PNLIP, PNLIPRP1, PNLIPRP2, PNPLA3, PPAP2A, PPAP2B, PPAP2C, UGCGL1, UGCGL2 55 ADH1B(1), ADH4(1), ADH6(1), AGK(2), AGPAT2(1), AGPAT3(2), AGPAT4(1), AGPAT6(2), AKR1A1(1), ALDH1A3(1), ALDH3A1(1), DGAT1(1), DGKA(1), DGKB(1), DGKD(2), DGKH(1), DGKI(2), DGKQ(1), DGKZ(1), GK(1), GPAM(2), LCT(3), LIPG(3), PNLIP(1), PPAP2A(1), PPAP2B(1) 22958195 36 28 36 9 9 3 4 10 10 0 0.277 1.000 1.000 451 HSA00910_NITROGEN_METABOLISM Genes involved in nitrogen metabolism AMT, ASNS, ASRGL1, CA1, CA12, CA13, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA8, CA9, CPS1, CTH, GLS, GLS2, GLUD1, GLUD2, GLUL, HAL 24 AMT(1), CA1(1), CA14(1), CA2(1), CA3(1), CA6(1), CA8(2), CA9(1), CTH(1), HAL(1) 8271239 11 10 11 7 3 3 0 4 1 0 0.925 1.000 1.000 452 PITX2PATHWAY The bicoid-related transcription factor Pitx2 is activated by Wnt binding to the Frizzled receptor and induces tissue-specific cell proliferation. APC, AXIN1, CREBBP, CTNNB1, DVL1, EP300, FZD1, GSK3B, HDAC1, HTATIP, LDB1, LEF1, PITX2, PPARBP, TRRAP, WNT1 13 APC(2), CREBBP(4), EP300(4), FZD1(2), GSK3B(1), LEF1(1), PITX2(1), TRRAP(1) 12349762 16 15 16 6 7 1 2 3 3 0 0.579 1.000 1.000 453 FRUCTOSE_AND_MANNOSE_METABOLISM AKR1B1, ALDOA, ALDOB, ALDOC, FBP1, FBP2, FPGT, GCK, GMDS, GMPPA, GMPPB, HK1, HK2, HK3, KHK, MPI, PFKFB1, PFKFB3, PFKFB4, PFKM, PFKP, PMM1, PMM2, SORD, TPI1 25 ALDOC(1), GCK(3), GMDS(1), HK2(1), HK3(2), PFKFB1(1), PFKM(1), PFKP(1), PMM1(1) 9356293 12 12 12 5 4 0 1 5 2 0 0.651 1.000 1.000 454 CARM_ERPATHWAY Methyltransferase CARM1 methylates CBP and co-activates estrogen receptors via Grip1. BRCA1, CARM1, CCND1, CREBBP, EP300, ERCC3, ESR1, GRIP1, GTF2A1, GTF2E1, GTF2F1, HDAC1, HDAC2, HDAC3, HDAC4, HDAC5, HDAC6, HIST2H3C, MEF2C, NCOR2, NR0B1, NRIP1, PELP1, POLR2A, PPARBP, PPARGC1, REA, SHARP, SRA1, TBP 25 CREBBP(4), EP300(4), ERCC3(1), ESR1(1), GRIP1(3), HDAC5(2), HDAC6(3), MEF2C(2), NCOR2(2), NRIP1(1), PELP1(1), POLR2A(2) 17999601 26 19 26 7 11 3 2 5 5 0 0.234 1.000 1.000 455 GLYCINE_SERINE_AND_THREONINE_METABOLISM ABP1, AGXT, AGXT2, ALAS1, ALAS2, AMT, AOC2, AOC3, ATP6V0C, SHMT1, BHMT, CBS, CHDH, CHKA, CHKB, CHKB, CPT1B, CTH, DAO, DLD, DMGDH, GAMT, GARS, GATM, GCAT, GLDC, MAOA, MAOB, PEMT, PISD, PLCB2, PLCG1, PLCG2, PSPH, SARDH, SARS, SHMT1, SHMT2, TARS 37 AGXT(1), AMT(1), AOC2(1), CBS(1), CHDH(2), CTH(1), DAO(1), GARS(1), GCAT(1), GLDC(2), PLCG1(1), PLCG2(1), SARDH(3), SARS(1), SHMT1(1), SHMT2(1), TARS(1) 16409564 21 19 21 7 7 2 1 5 6 0 0.723 1.000 1.000 456 LYSINE_DEGRADATION AADAT, AASDH, AASDHPPT, AASS, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, ATP6V0C, SHMT1, BAT8, BBOX1, DLST, DLSTP, DOT1L, ECHS1, EHHADH, EHMT1, EHMT2, GCDH, HADHA, PLOD1, PLOD2, PLOD3, SDS, SHMT1, SHMT2, TMLHE 31 AADAT(1), AASDH(1), ACAT1(1), ALDH1A1(1), ALDH1A2(3), ALDH1A3(1), ALDH3A1(1), BBOX1(1), DOT1L(3), EHHADH(2), EHMT2(1), PLOD1(1), PLOD3(1), SHMT1(1), SHMT2(1) 14480081 20 18 19 6 5 3 3 7 2 0 0.411 1.000 1.000 457 MONOAMINE_GPCRS ADRA1A, ADRA1B, ADRA1D, ADRA2A, ADRA2C, ADRB1, ADRB2, ADRB3, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, DRD1, DRD2, DRD3, DRD4, DRD5, HRH1, HRH2, HTR1A, HTR1B, HTR1D, HTR1E, HTR1F, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, HTR7, LOC93164 32 ADRA1A(1), ADRA1B(2), ADRA1D(2), ADRA2A(2), ADRA2C(1), ADRB1(1), CHRM4(1), DRD2(1), DRD3(1), HTR1A(2), HTR1D(1), HTR1E(2), HTR2A(2), HTR2B(1), HTR2C(2), HTR4(1), HTR5A(1), HTR6(2) 10050851 26 24 26 10 11 4 1 7 3 0 0.389 1.000 1.000 458 HSA00252_ALANINE_AND_ASPARTATE_METABOLISM Genes involved in alanine and aspartate metabolism AARS, AARS2, ABAT, ACY3, ADSL, ADSS, ADSSL1, AGXT, AGXT2, ASL, ASNS, ASPA, ASRGL1, ASS1, CAD, CRAT, DARS, DARS2, DDO, DLAT, DLD, GAD1, GAD2, GOT1, GOT2, GPT, GPT2, NARS, NARS2, PC, PDHA1, PDHA2, PDHB 33 AARS(1), ACY3(1), AGXT(1), CAD(1), DARS2(1), GAD2(4), GOT1(1), NARS2(1), PC(1), PDHA2(2) 14780591 14 14 14 6 5 1 0 3 5 0 0.762 1.000 1.000 459 DCPATHWAY Dendritic cells internalize and present antigen, after which they migrate to lymphocyte-rich tissues and induce T and B cell differentiation. ANPEP, CD2, CD33, CD5, CD7, CSF2, IFNA1, IFNB1, IFNG, IL10, IL12A, IL12B, IL13, IL3, IL4, IL5, ITGAX, TLR2, TLR4, TLR7, TLR9, TNFRSF5 21 IL12A(1), IL4(1), TLR7(1), TLR9(1) 7248393 4 4 4 3 3 0 0 0 1 0 0.822 1.000 1.000 460 HSA00020_CITRATE_CYCLE Genes involved in citrate cycle (TCA cycle) ACLY, ACO1, ACO2, CLYBL, CS, DLD, DLST, FH, IDH1, IDH2, IDH3A, IDH3B, IDH3G, LOC283398, LOC441996, MDH1, MDH2, OGDH, OGDHL, PC, PCK1, PCK2, SDHA, SDHB, SDHC, SDHD, SUCLA2, SUCLG1, SUCLG2 26 ACLY(1), ACO2(1), FH(1), IDH3A(1), PC(1), PCK2(2), SDHA(1), SDHC(1) 11286583 9 8 9 5 1 0 2 3 3 0 0.902 1.000 1.000 461 APOPTOSIS APAF1, BAD, BAK1, BCL2L7P1, BAX, BCL2, BCL2L1, BCL2L11, BID, BIRC2, BIRC3, BIRC4, BIRC5, BNIP3L, CASP1, CASP10, CASP1, COPl, CASP2, CASP3, CASP4, CASP6, CASP7, CASP8, CASP9, CHUK, CYCS, DFFA, DFFB, FADD, FAS, FASLG, GZMB, HELLS, HRK, IKBKB, IKBKG, IRF1, IRF2, IRF3, IRF4, IRF5, IRF6, IRF7, JUN, LTA, MAP2K4, MAP3K1, MAPK10, MDM2, MYC, NFKB1, NFKBIA, NFKBIB, NFKBIE, PRF1, RELA, RIPK1, TNF, TNFRSF10B, TNFRSF1A, TNFRSF1B, TNFRSF21, TNFRSF25, TNFRSF25, PLEKHG5, TNFSF10, TP53, TP73, TRADD, TRAF1, TRAF2, TRAF3 65 APAF1(1), BIRC2(1), CASP1(2), DFFA(1), FAS(1), FASLG(1), IRF2(1), IRF3(2), IRF4(2), IRF6(1), MAP2K4(1), MDM2(1), PRF1(1), RELA(2), RIPK1(1), TNF(1), TNFRSF10B(1), TNFRSF21(1), TRAF1(1), TRAF2(3) 22199872 26 22 26 6 4 3 2 8 9 0 0.436 1.000 1.000 462 MPRPATHWAY Progesterone binding to its intracellular receptor activates the MAPK pathway and induces oocyte maturation; binding to membrane receptor inhibits adenylyl cyclase. ACTA1, ADCY1, CAP1, CCNB1, CDC2, CDC25C, GNAI1, GNAS, GNB1, GNGT1, HRAS, MAPK1, MAPK3, MYT1, PIN1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RPS6KA1, SRC 22 ADCY1(1), CAP1(1), GNAI1(1), GNAS(2), GNB1(1), GNGT1(1), HRAS(3), MAPK1(1), MYT1(1), PRKAR1A(1), PRKAR1B(1), RPS6KA1(1) 8042509 15 15 15 7 3 1 2 8 1 0 0.895 1.000 1.000 463 PPARAPATHWAY Peroxisome proliferators regulate gene expression via PPAR/RXR heterodimers which bind to peroxisome-proliferator response elements (PPREs). ACOX1, APOA1, APOA2, CD36, CITED2, CPT1B, CREBBP, DUSP1, DUT, EHHADH, EP300, FABP1, FAT, FRA8B, HSD17B4, HSPA1A, HSPCA, INS, JUN, LPL, MAPK1, MAPK3, ME1, MRPL11, MYC, NCOA1, NCOR1, NCOR2, NFKBIA, NOS2A, NR0B2, NR1H3, NR2F1, NRIP1, PDGFA, PIK3CA, PIK3R1, PPARA, PPARBP, PPARGC1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PTGS2, RB1, RELA, RXRA, SP1, SRA1, STAT5A, STAT5B, TNF 50 CREBBP(4), DUSP1(1), EHHADH(2), EP300(4), HSD17B4(1), MAPK1(1), ME1(2), NCOR1(6), NCOR2(2), NR2F1(1), NRIP1(1), PIK3CA(10), PIK3R1(1), PPARA(2), PRKAR1A(1), PRKAR1B(1), PRKCA(2), PTGS2(2), RB1(2), RELA(2), SP1(1), STAT5B(1), TNF(1) 24730142 51 38 51 12 15 9 6 11 9 1 0.0940 1.000 1.000 464 CARM1PATHWAY The methyltransferase CARM1 interacts with transcription factors such as CBP/p300 and methylates histones H3 and H4. CARM1, CREB1, CREBBP, EP300, NCOA3, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RARA, RXRA 13 CREBBP(4), EP300(4), PRKAR1A(1), PRKAR1B(1) 8075753 10 9 10 7 4 0 1 4 1 0 0.946 1.000 1.000 465 HSA00510_N_GLYCAN_BIOSYNTHESIS Genes involved in N-glycan biosynthesis ALG1, ALG10, ALG10B, ALG11, ALG12, ALG13, ALG14, ALG2, ALG3, ALG5, ALG6, ALG8, ALG9, B4GALT1, B4GALT2, B4GALT3, DAD1, DDOST, DHDDS, DOLPP1, DPAGT1, DPM1, FUT8, GANAB, GCS1, MAN1A1, MAN1A2, MAN1B1, MAN1C1, MAN2A1, MGAT1, MGAT2, MGAT3, MGAT4A, MGAT4B, MGAT5, MGAT5B, RFT1, RPN1, RPN2, ST6GAL1, STT3B 41 ALG12(1), ALG14(2), B4GALT1(2), B4GALT2(1), GANAB(1), MAN1A1(2), MAN1C1(1), MAN2A1(1), MGAT5(1), MGAT5B(2), RPN1(1), ST6GAL1(1) 16537132 16 13 16 4 7 1 1 2 5 0 0.513 1.000 1.000 466 HSA01031_GLYCAN_STRUCTURES_BIOSYNTHESIS_2 Genes involved in glycan structures - biosynthesis 2 A4GALT, ABO, B3GALNT1, B3GALT1, B3GALT2, B3GALT4, B3GALT5, B3GNT1, B3GNT2, B3GNT3, B3GNT4, B3GNT5, B4GALNT1, B4GALT1, B4GALT2, B4GALT3, B4GALT4, B4GALT6, FUT1, FUT2, FUT3, FUT4, FUT5, FUT6, FUT7, FUT9, GBGT1, GCNT2, PIGA, PIGB, PIGC, PIGF, PIGG, PIGH, PIGK, PIGL, PIGM, PIGN, PIGO, PIGP, PIGQ, PIGS, PIGT, PIGU, PIGV, PIGX, PIGZ, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4, ST3GAL5, ST3GAL6, ST6GALNAC3, ST6GALNAC4, ST6GALNAC5, ST6GALNAC6, ST8SIA1, ST8SIA5, UGCG, UGCGL1, UGCGL2 60 A4GALT(2), B3GALNT1(1), B3GALT2(1), B3GALT5(2), B3GNT3(1), B3GNT4(2), B4GALNT1(2), B4GALT1(2), B4GALT2(1), B4GALT6(1), FUT1(1), FUT2(1), FUT3(1), GCNT2(1), PIGA(1), PIGB(2), PIGO(1), PIGQ(3), ST3GAL1(2), ST8SIA1(1) 18985241 29 25 29 9 12 3 3 6 4 1 0.482 1.000 1.000 467 INOSITOL_PHOSPHATE_METABOLISM IMPA1, INPP1, INPP4A, INPP4B, INPP5A, INPPL1, ITPKA, ITPKB, MIOX, OCRL, PIK3C2A, PIK3C2B, PIK3C2G, PIK3CA, PIK3CB, PIK3CG, PIK4CA, PIK4CA, LOC220686, PIP5K2B, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCG1, PLCG2 23 IMPA1(1), ITPKB(2), OCRL(1), PIK3C2A(1), PIK3C2B(2), PIK3CA(10), PIK3CB(1), PIK3CG(3), PLCB1(2), PLCB4(3), PLCG1(1), PLCG2(1) 17481385 28 22 28 8 9 9 5 5 0 0 0.244 1.000 1.000 468 NUCLEAR_RECEPTORS ALK, AR, ESR1, ESR2, ESRRA, HNF4A, NPM1, NR0B1, NR1D2, NR1H2, NR1H3, NR1I2, NR1I3, NR2C2, NR2E1, NR2F1, NR2F2, NR2F6, NR3C1, NR4A1, NR4A2, NR5A1, NR5A2, PGR, PPARA, PPARD, PPARG, RARA, RARB, RARG, ROR1, RORA, RORC, RXRA, RXRB, RXRG, THRA, THRA, NR1D1, THRB, VDR 40 ALK(1), ESR1(1), NR1D2(1), NR1I2(2), NR1I3(1), NR2E1(1), NR2F1(1), NR2F2(1), NR5A2(1), PGR(1), PPARA(2), PPARD(1), PPARG(1), RARB(2), ROR1(1), RXRB(2), RXRG(1), THRA(2) 16414238 23 19 23 6 13 2 3 2 3 0 0.232 1.000 1.000 469 HSA00350_TYROSINE_METABOLISM Genes involved in tyrosine metabolism ABP1, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, AOX1, ARD1A, CARM1, COMT, DBH, DCT, DDC, ECH1, ESCO1, ESCO2, FAH, GOT1, GOT2, GSTZ1, HEMK1, HGD, HPD, LCMT1, LCMT2, LYCAT, MAOA, MAOB, METTL2B, METTL6, MIF, MYST3, MYST4, NAT5, NAT6, PNMT, PNPLA3, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, SH3GLB1, TAT, TH, TPO, TYR, TYRP1, WBSCR22 56 ADH1B(1), ADH4(1), ADH6(1), ALDH1A3(1), ALDH3A1(1), ALDH3B1(1), AOC2(1), AOX1(1), DBH(3), ESCO1(4), FAH(1), GOT1(1), HGD(1), HPD(1), METTL6(1), NAT6(1), PNMT(1), PRMT3(1), PRMT5(2), PRMT8(1), TPO(1) 23179177 27 24 27 9 5 2 4 7 9 0 0.592 1.000 1.000 470 CALCINEURIN_NF_AT_SIGNALING Mouse genes associated with signal transduction through calcium, calcineurin, and NF-AT. ACTB, BAD, BCL2, CABIN1, CALM1, CALM2, CALM3, CAMK2B, CAMK4, CD3E, CD3G, CD3Z, CD69, CDKN1A, CEBPB, CNR1, CREBBP, CSF2, CSNK2A1, CSNK2B, CTLA4, EGR2, EGR3, EP300, FCER1A, FCGR3A, FKBP1B, FLJ14639, FOS, FOSL1, GAPD, GATA3, GATA4, GRLF1, GSK3A, GSK3B, HRAS, ICOS, IFNA1, IFNB1, IFNG, IL10, IL13, IL1B, IL2, IL2RA, IL3, IL4, IL6, IL8, IL8RA, ITK, JUNB, KPNA5, KPNB3, MAP2K7, MAPK14, MAPK8, MAPK9, MEF2A, MEF2B, MEF2D, MYF5, NCK2, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NFKB2, NFKBIB, NFKBIE, NPPB, NUP214, OPRD1, P2RX7, PAK1, PIN1, PPIA, PPP3CB, PPP3CC, PPP3R1, PTPRC, RELA, RPL13A, SFN, SLA, SP1, SP3, TGFB1, TNF, TNFSF5, TNFSF6, TRAF2, TRPV6, VAV1, VAV2, VAV3, VEGF, XPO5 92 CABIN1(1), CAMK4(2), CD69(1), CDKN1A(2), CEBPB(1), CNR1(2), CREBBP(4), EGR3(1), EP300(4), FCER1A(1), GSK3A(2), GSK3B(1), HRAS(3), IL4(1), IL6(1), ITK(1), KPNA5(2), MAP2K7(2), MEF2A(1), MEF2D(1), NFATC1(1), NFATC2(1), NUP214(1), PPP3CC(1), PTPRC(3), RELA(2), SP1(1), SP3(2), TGFB1(1), TNF(1), TRAF2(3), TRPV6(1), VAV1(3), VAV2(1), VAV3(1), XPO5(1) 35614327 58 46 58 11 21 6 6 18 7 0 0.0260 1.000 1.000 471 SPRYPATHWAY Four members of the Sprouty protein family block proliferative EGF signals by binding Grb-2, preventing Ras and MAP kinase activation. CBL, EGF, EGFR, GRB2, HRAS, MAP2K1, MAPK1, MAPK3, PTPRB, RAF1, RASA1, SHC1, SOS1, SPRY1, SPRY2, SPRY3, SPRY4, SRC 18 EGFR(2), GRB2(1), HRAS(3), MAPK1(1), PTPRB(1), RAF1(1), SHC1(2), SOS1(1), SPRY3(1) 9725760 13 13 13 5 6 1 2 3 1 0 0.687 1.000 1.000 472 HISTIDINE_METABOLISM ABP1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH9A1, AOC2, AOC3, ASPA, CNDP1, DDC, HAL, HARS, HARSL, HDC, HNMT, MAOA, MAOB, PRPS1, PRPS2 24 ALDH1A1(1), ALDH1A2(3), ALDH1A3(1), ALDH3A1(1), ALDH3B1(1), AOC2(1), CNDP1(2), HAL(1) 9500415 11 10 10 7 3 2 1 4 1 0 0.930 1.000 1.000 473 HSA04612_ANTIGEN_PROCESSING_AND_PRESENTATION Genes involved in antigen processing and presentation B2M, CALR, CANX, CD4, CD74, CD8A, CD8B, CIITA, CREB1, CTSB, CTSL1, CTSS, HLA-A, HLA-A29.1, HLA-B, HLA-C, HLA-DMA, HLA-DMB, HLA-DOA, HLA-DOB, HLA-DPA1, HLA-DPB1, HLA-DQA1, HLA-DQA2, HLA-DQB1, HLA-DQB2, HLA-DRA, HLA-DRB1, HLA-DRB3, HLA-DRB4, HLA-DRB5, HLA-E, HLA-F, HLA-G, HSP90AA1, HSP90AB1, HSPA5, IFI30, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, KIR2DL1, KIR2DL2, KIR2DL3, KIR2DL4, KIR2DL5A, KIR2DS1, KIR2DS2, KIR2DS3, KIR2DS4, KIR2DS5, KIR3DL1, KIR3DL2, KIR3DL3, KLRC1, KLRC2, KLRC3, KLRC4, KLRD1, LGMN, LTA, NFYA, NFYB, NFYC, PDIA3, PSME1, PSME2, RFX5, RFXANK, RFXAP, TAP1, TAP2, TAPBP 73 B2M(1), CD8A(1), CD8B(1), HLA-DRA(1), HLA-F(1), HLA-G(1), HSP90AA1(1), HSP90AB1(1), IFI30(1), IFNA10(1), IFNA13(1), IFNA16(1), KIR2DL1(1), KIR3DL1(2), NFYA(1), NFYC(2), PSME1(1), TAP1(1), TAP2(1) 18123186 21 18 21 6 3 7 5 4 2 0 0.228 1.000 1.000 474 HSA04520_ADHERENS_JUNCTION Genes involved in adherens junction ACP1, ACTB, ACTG1, ACTN1, ACTN2, ACTN3, ACTN4, ACVR1B, ACVR1C, BAIAP2, CDC42, CDH1, CREBBP, CSNK2A1, CSNK2A2, CSNK2B, CTNNA1, CTNNA2, CTNNA3, CTNNB1, CTNND1, EGFR, EP300, ERBB2, FARP2, FER, FGFR1, FYN, IGF1R, INSR, IQGAP1, LEF1, LMO7, MAP3K7, MAPK1, MAPK3, MET, MLLT4, NLK, PARD3, PTPN1, PTPN6, PTPRB, PTPRF, PTPRJ, PTPRM, PVRL1, PVRL2, PVRL3, PVRL4, RAC1, RAC2, RAC3, RHOA, SMAD2, SMAD3, SMAD4, SNAI1, SNAI2, SORBS1, SRC, SSX2IP, TCF7, TCF7L1, TCF7L2, TGFBR1, TGFBR2, TJP1, VCL, WAS, WASF1, WASF2, WASF3, WASL, YES1 74 ACTG1(1), ACVR1B(1), CDH1(4), CREBBP(4), CSNK2A2(1), CTNNA2(4), CTNNA3(1), EGFR(2), EP300(4), ERBB2(1), IGF1R(1), IQGAP1(3), LEF1(1), LMO7(1), MAP3K7(2), MAPK1(1), MET(1), MLLT4(1), NLK(1), PTPN1(1), PTPRB(1), PTPRF(2), PVRL1(1), RAC1(1), RAC2(1), SMAD2(1), SMAD3(1), SMAD4(4), SNAI1(1), SORBS1(2), SSX2IP(1), TCF7L1(1), TCF7L2(2), TGFBR1(2), TJP1(1), WASF2(1) 46092354 59 49 58 10 15 3 10 21 10 0 0.0328 1.000 1.000 475 IL2PATHWAY IL-2 promotes proliferation via JAK and MAP kinase and has surface receptors on activated B cells, LPS-treated monocytes, and many T cells. CSNK2A1, ELK1, FOS, GRB2, HRAS, IL2, IL2RA, IL2RB, IL2RG, JAK1, JAK3, JUN, LCK, MAP2K1, MAPK3, MAPK8, RAF1, SHC1, SOS1, STAT5A, STAT5B, SYK 22 GRB2(1), HRAS(3), JAK1(3), RAF1(1), SHC1(2), SOS1(1), STAT5B(1), SYK(2) 9095992 14 13 14 7 7 3 2 1 1 0 0.726 1.000 1.000 476 HSA04350_TGF_BETA_SIGNALING_PATHWAY Genes involved in TGF-beta signaling pathway ACVR1, ACVR1B, ACVR1C, ACVR2A, ACVR2B, ACVRL1, AMH, AMHR2, BMP2, BMP4, BMP5, BMP6, BMP7, BMP8A, BMP8B, BMPR1A, BMPR1B, BMPR2, CDKN2B, CHRD, COMP, CREBBP, CUL1, DCN, E2F4, E2F5, EP300, FST, GDF5, GDF6, GDF7, hCG_1982709, ID1, ID2, ID3, ID4, IFNG, INHBA, INHBB, INHBC, INHBE, LEFTY1, LEFTY2, LTBP1, MAPK1, MAPK3, MYC, NODAL, NOG, PITX2, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, RBL1, RBL2, RBX1, RHOA, ROCK1, ROCK2, RPS6KB1, RPS6KB2, SKP1, SMAD1, SMAD2, SMAD3, SMAD4, SMAD5, SMAD6, SMAD7, SMAD9, SMURF1, SMURF2, SP1, TFDP1, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, THBS1, THBS2, THBS3, THBS4, TNF, ZFYVE16, ZFYVE9 89 ACVR1B(1), ACVR2A(1), ACVRL1(1), BMP5(2), BMP6(1), BMP7(3), BMP8B(1), BMPR2(1), CHRD(1), COMP(1), CREBBP(4), EP300(4), FST(1), GDF6(1), GDF7(1), INHBA(2), INHBC(1), INHBE(1), LTBP1(3), MAPK1(1), PITX2(1), PPP2R1B(1), PPP2R2B(3), PPP2R2C(1), RBL2(1), ROCK1(5), RPS6KB2(1), SMAD2(1), SMAD3(1), SMAD4(4), SMAD6(1), SMAD9(1), SP1(1), TFDP1(1), TGFB1(1), TGFB2(1), TGFBR1(2), THBS1(2), THBS4(1), TNF(1), ZFYVE16(1), ZFYVE9(1) 38793123 65 54 64 14 18 8 13 20 6 0 0.0462 1.000 1.000 477 ST_P38_MAPK_PATHWAY p38 is a MAP kinase regulated by cytokines and cellular stress. AKT1, ATF1, CDC42, CREB1, CREB3, CREB5, DUSP1, DUSP10, EEF2K, EIF4E, ELK1, GADD45A, HSPB1, IL1R1, MAP2K3, MAP2K4, MAP2K6, MAP3K10, MAP3K4, MAP3K5, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAPK1, MAPK11, MAPK12, MAPK13, MAPK14, MAPKAPK2, MAPKAPK5, MKNK1, MKNK2, MYEF2, NFKB1, NR2C2, SRF, TRAF6 35 AKT1(1), CREB3(1), DUSP1(1), EEF2K(2), MAP2K4(1), MAP3K10(4), MAP3K5(1), MAP3K7(2), MAPK1(1), MAPKAPK5(1) 13045956 15 11 15 9 7 2 1 2 3 0 0.932 1.000 1.000 478 HSA05110_CHOLERA_INFECTION Genes involved in cholera - infection ACTG1, ACTG2, ADCY3, ADCY9, AK1, ARF1, ARF3, ARF4, ARF5, ARF6, ARL4D, ATP6V0A1, ATP6V0A2, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0D1, ATP6V0D2, ATP6V0E1, ATP6V1A, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1E2, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, ERO1L, GNAS, PDIA4, PLCG1, PLCG2, PRKCA, SEC61A1, SEC61A2, SEC61B, SEC61G, TRIM23 41 ACTG1(1), ADCY3(1), ADCY9(2), ATP6V0A2(3), ATP6V1A(2), ATP6V1C2(3), ATP6V1E2(1), ATP6V1F(1), ATP6V1H(1), GNAS(2), PLCG1(1), PLCG2(1), PRKCA(2), SEC61A1(1), SEC61A2(1) 14393271 23 23 23 8 4 4 2 11 2 0 0.590 1.000 1.000 479 ST_JNK_MAPK_PATHWAY JNKs are MAP kinases regulated by several levels of kinases (MAPKK, MAPKKK) and phosphorylate transcription factors and regulatory proteins. AKT1, ATF2, CDC42, DLD, DUSP10, DUSP4, DUSP8, GAB1, GADD45A, GCK, IL1R1, JUN, MAP2K4, MAP2K5, MAP2K7, MAP3K1, MAP3K10, MAP3K11, MAP3K12, MAP3K13, MAP3K2, MAP3K3, MAP3K4, MAP3K5, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAP3K9, MAPK10, MAPK7, MAPK8, MAPK9, MYEF2, NFATC3, NR2C2, PAPPA, SHC1, TP53, TRAF6, ZAK 37 AKT1(1), ATF2(1), DUSP8(2), GCK(3), MAP2K4(1), MAP2K7(2), MAP3K10(4), MAP3K11(2), MAP3K12(1), MAP3K13(1), MAP3K5(1), MAP3K7(2), MAP3K9(1), PAPPA(3), SHC1(2) 19381873 27 20 27 9 11 3 2 3 8 0 0.536 1.000 1.000 480 ST_GA13_PATHWAY G-alpha-13 influences the actin cytoskeleton and activates protein kinase D, PI3K, and Pyk2. AKT1, AKT2, AKT3, ARHGEF11, BCL2, BF, CDC42, DLG4, GNA13, IKBKG, LPA, MAP2K4, MAP3K1, MAP3K5, MAPK8, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PDK1, PHKA2, PI3, PIK3CB, PLD1, PLD2, PLD3, PRKCM, PTK2, RDX, ROCK1, ROCK2, SERPINA4, SRF, TBXA2R 34 AKT1(1), AKT2(1), ARHGEF11(2), GNA13(1), LPA(1), MAP2K4(1), MAP3K5(1), NFKBIL1(1), PDK1(1), PHKA2(1), PIK3CB(1), PLD1(2), PTK2(2), ROCK1(5), TBXA2R(2) 19140345 23 19 22 7 5 3 4 4 7 0 0.498 1.000 1.000 481 ST_FAS_SIGNALING_PATHWAY The Fas receptor induces apoptosis and NF-kB activation when bound to Fas ligand. ADPRT, ALG2, BAK1, BAX, BFAR, BIRC4, BTK, CAD, CASP10, CASP3, CASP8, CASP8AP2, CD7, CDK2AP1, CSNK1A1, DAXX, DEDD, DEDD2, DFFA, DIABLO, EGFR, EPHB2, FADD, FAF1, FAIM2, FREQ, HRB, HSPB1, IL1A, IL8, MAP2K4, MAP2K7, MAP3K1, MAP3K5, MAPK1, MAPK10, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MCP, MET, NFAT5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, NR0B2, PFN1, PFN2, PTPN13, RALBP1, RIPK1, ROCK1, SMPD1, TNFRSF6, TNFRSF6B, TP53, TPX2, TRAF2, TUFM, VIL2 58 BTK(1), CAD(1), DAXX(1), DEDD2(1), DFFA(1), EGFR(2), EPHB2(3), FAF1(2), MAP2K4(1), MAP2K7(2), MAP3K5(1), MAPK1(1), MAPK8IP3(2), MET(1), NFKBIL1(1), PFN1(1), PFN2(2), PTPN13(1), RALBP1(1), RIPK1(1), ROCK1(5), TNFRSF6B(1), TPX2(1), TRAF2(3) 28173141 37 28 36 9 11 2 5 10 9 0 0.337 1.000 1.000 482 TRANSLATION_FACTORS ANKHD1, ANKHD1, MASK_BP3, EEF1A2, EEF1B2, EEF1D, EEF1G, EEF2, EEF2K, EIF1AX, EIF1AY, EIF2AK1, EIF2AK2, EIF2AK3, EIF2B1, EIF2B2, EIF2B3, EIF2B4, EIF2B5, EIF2S1, EIF2S2, EIF2S3, EIF3S1, EIF3S10, EIF3S2, EIF3S3, EIF3S4, EIF3S5, EIF3S6, EIF3S7, EIF3S8, EIF3S9, EIF4A1, EIF4A2, EIF4E, EIF4EBP1, EIF4EBP2, EIF4G1, EIF4G3, EIF5, EIF5A, EIF5B, ETF1, GSPT2, ITGB4BP, KIAA0664, PABPC1, PABPC3, PABPC1, LOC341315, PAIP1, PAIP1, LOC388345, SLC35A4, SUI1, WBSCR1 37 EEF1A2(2), EEF2(1), EEF2K(2), EIF2AK3(4), EIF2B2(1), EIF2B3(1), EIF4A1(1), EIF4G1(1), EIF4G3(2), EIF5B(1) 17129103 16 15 16 8 3 1 3 4 5 0 0.872 1.000 1.000 483 HSA00562_INOSITOL_PHOSPHATE_METABOLISM Genes involved in inositol phosphate metabolism CARKL, FN3K, IMPA1, IMPA2, INPP1, INPP4A, INPP4B, INPP5A, INPP5B, INPP5E, INPPL1, IPMK, ISYNA1, ITGB1BP3, ITPK1, ITPKA, ITPKB, MINPP1, MIOX, OCRL, PI4KA, PI4KB, PIB5PA, PIK3C3, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIP4K2A, PIP4K2B, PIP4K2C, PIP5K1A, PIP5K1B, PIP5K1C, PIP5K3, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCD3, PLCD4, PLCE1, PLCG1, PLCG2, PLCZ1, PTEN, PTPMT1, SKIP, SYNJ1, SYNJ2 46 IMPA1(1), INPP5B(1), IPMK(1), ITPK1(2), ITPKB(2), OCRL(1), PI4KA(2), PI4KB(2), PIK3CA(10), PIK3CB(1), PIK3CG(3), PIP5K1C(2), PLCB1(2), PLCB4(3), PLCD3(1), PLCD4(1), PLCE1(2), PLCG1(1), PLCG2(1), PLCZ1(2), SYNJ1(3), SYNJ2(2) 28755086 46 39 46 11 11 11 8 15 1 0 0.102 1.000 1.000 484 HSA03030_DNA_POLYMERASE Genes involved in DNA polymerase POLA1, POLA2, POLB, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, POLE3, POLE4, POLG, POLG2, POLH, POLI, POLK, POLL, POLM, POLQ, POLS, PRIM1, PRIM2, REV1, REV3L, RFC5 24 POLA1(1), POLD1(1), POLD3(1), POLE(2), POLG(1), POLL(1), POLM(1), POLQ(3), REV1(1), REV3L(1) 15784260 13 11 13 8 3 1 3 2 4 0 0.961 1.000 1.000 485 INTEGRIN_MEDIATED_CELL_ADHESION_KEGG AKT1, AKT3, BCAR1, CAPN1, CAPN10, CAPN11, CAPN2, CAPN3, CAPN5, CAPN6, CAPN7, CAPN9, CAPNS1, CAV1, CAV2, CAV3, CDC42, CRK, CSK, DKFZp434E1119, DOCK1, FLJ14825, FLJ40125, FYN, GIT2, GRB2, ILK, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAD, ITGAE, ITGAL, ITGAM, ITGAV, ITGAX, ITGB1, ITGB2, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, LOC283874, PDPK1, MAP2K1, MAP2K2, MAP2K3, MAP2K6, MAPK10, MAPK12, MAPK4, MAPK6, MAPK7, MGC17301, MYLK2, PAK1, PAK2, PAK3, PAK4, PAK6, PDPK1, PIK3R2, PTK2, PXN, RAC1, RAC2, RAC3, RAP1B, RAPGEF1, RHO, ROCK1, ROCK2, SDCCAG8, SEPP1, SHC1, SHC3, SORBS1, SOS1, SRC, TLN1, TNS, TNS1, VASP, VAV2, VAV3, VCL, ZYX 90 AKT1(1), BCAR1(1), CAPN11(2), CAPN3(1), CAPNS1(1), CAV3(1), CRK(1), GIT2(1), GRB2(1), ITGA10(1), ITGA11(2), ITGA2(1), ITGA2B(3), ITGA3(2), ITGA6(2), ITGA7(1), ITGA9(2), ITGAD(1), ITGAL(3), ITGAM(2), ITGAV(2), ITGB2(2), ITGB4(2), ITGB5(1), ITGB6(2), ITGB8(1), MYLK2(2), PAK2(1), PDPK1(1), PIK3R2(2), PTK2(2), PXN(1), RAC1(1), RAC2(1), RAPGEF1(3), ROCK1(5), SHC1(2), SORBS1(2), SOS1(1), TLN1(2), TNS1(6), VAV2(1), VAV3(1) 52497819 74 56 73 13 21 10 5 31 7 0 0.0170 1.000 1.000 486 HSA00512_O_GLYCAN_BIOSYNTHESIS Genes involved in O-glycan biosynthesis B3GNT6, B4GALT5, C1GALT1, C1GALT1C1, GALNT1, GALNT10, GALNT11, GALNT12, GALNT13, GALNT14, GALNT17, GALNT2, GALNT3, GALNT4, GALNT5, GALNT6, GALNT7, GALNT8, GALNT9, GALNTL1, GALNTL2, GALNTL4, GALNTL5, GCNT1, GCNT3, GCNT4, OGT, ST3GAL1, ST3GAL2, ST6GALNAC1, WBSCR17 30 GALNT10(2), GALNT11(1), GALNT13(1), GALNT3(2), GALNT8(1), GALNTL5(3), OGT(1), ST3GAL1(2), WBSCR17(1) 12562043 14 12 14 5 6 2 1 4 1 0 0.623 1.000 1.000 487 HSA00410_BETA_ALANINE_METABOLISM Genes involved in beta-alanine metabolism ABAT, ABP1, ACADM, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, AOC2, AOC3, CNDP1, DPYD, DPYS, ECHS1, EHHADH, GAD1, GAD2, HADHA, HIBCH, MLYCD, SMS, SRM, UPB1 25 ALDH1A3(1), ALDH3A1(1), AOC2(1), CNDP1(2), DPYD(2), DPYS(1), EHHADH(2), GAD2(4) 10547779 14 14 14 7 3 4 2 4 1 0 0.741 1.000 1.000 488 HSA00051_FRUCTOSE_AND_MANNOSE_METABOLISM Genes involved in fructose and mannose metabolism AKR1B1, AKR1B10, ALDOA, ALDOB, ALDOC, FBP1, FBP2, FPGT, FUK, GMDS, GMPPA, GMPPB, HK1, HK2, HK3, HSD3B7, KHK, LHPP, MPI, MTMR1, MTMR2, MTMR6, PFKFB1, PFKFB2, PFKFB3, PFKFB4, PFKL, PFKM, PFKP, PGM2, PHPT1, PMM1, PMM2, RDH11, RDH12, RDH13, RDH14, SORD, TPI1, TSTA3, UGCGL1, UGCGL2 40 ALDOC(1), FUK(1), GMDS(1), HK2(1), HK3(2), PFKFB1(1), PFKL(1), PFKM(1), PFKP(1), PGM2(1), PMM1(1), RDH12(1), TSTA3(2) 14565824 15 13 15 7 3 1 1 7 3 0 0.751 1.000 1.000 489 ST_T_CELL_SIGNAL_TRANSDUCTION On activation of the T cell receptor, phospholipase C is activated to produce second messengers DAG and PIP3, both required for T cell activation. CBL, CD28, CD3D, CSK, CTLA4, DAG1, DTYMK, EPHB2, FBXW7, GRAP2, GRB2, ITK, ITPKA, ITPKB, LAT, LCK, LCP2, MAPK1, NCK1, NFAT5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PAG, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PLCG1, PTPRC, RAF1, RASGRP1, RASGRP2, RASGRP3, RASGRP4, SOS1, SOS2, VAV1, ZAP70 44 DAG1(1), EPHB2(3), GRB2(1), ITK(1), ITPKB(2), MAPK1(1), NFKBIL1(1), PAK2(1), PLCG1(1), PTPRC(3), RAF1(1), SOS1(1), VAV1(3), ZAP70(2) 21872986 22 21 22 6 10 3 2 5 2 0 0.379 1.000 1.000 490 HSA00010_GLYCOLYSIS_AND_GLUCONEOGENESIS Genes involved in glycolysis and gluconeogenesis ACSS1, ACSS2, ACYP1, ACYP2, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AKR1A1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH7A1, ALDH9A1, ALDOA, ALDOB, ALDOC, BPGM, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, G6PC2, GALM, GAPDH, GAPDHS, GCK, GPI, HK1, HK2, HK3, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, PDHA1, PDHA2, PDHB, PFKL, PFKM, PFKP, PGAM1, PGAM2, PGAM4, PGK1, PGK2, PGM1, PGM3, PKLR, PKM2, TPI1 64 ADH1B(1), ADH4(1), ADH6(1), AKR1A1(1), ALDH1A3(1), ALDH3A1(1), ALDH3B1(1), ALDOC(1), ENO1(2), GCK(3), HK2(1), HK3(2), PDHA2(2), PFKL(1), PFKM(1), PFKP(1), PGK2(1), PGM1(1), PGM3(1) 22730375 24 23 24 8 7 0 5 7 5 0 0.488 1.000 1.000 491 GPCRPATHWAY G-protein coupled receptors activate adenylyl cyclase, which converts ATP to cAMP, to activate second messenger pathways. ADCY1, CALM1, CALM2, CALM3, CREB1, ELK1, FOS, GNAI1, GNAQ, GNAS, GNB1, GNGT1, HRAS, JUN, MAP2K1, MAPK3, NFATC1, NFATC2, NFATC3, NFATC4, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, RAF1, RPS6KA3, SYT1 34 ADCY1(1), GNAI1(1), GNAS(2), GNB1(1), GNGT1(1), HRAS(3), NFATC1(1), NFATC2(1), PLCG1(1), PPP3CA(1), PPP3CC(1), PRKAR1A(1), PRKAR1B(1), PRKCA(2), RAF1(1), SYT1(1) 13612572 20 16 20 7 5 0 4 11 0 0 0.686 1.000 1.000 492 APOPTOSIS_GENMAPP APAF1, BAK1, BCL2L7P1, BAX, BCL2, BCL2L1, BID, BIRC2, BIRC3, BIRC4, CASP2, CASP3, CASP6, CASP7, CASP8, CASP9, CYCS, FADD, FAS, FASLG, GZMB, IKBKG, JUN, MAP2K4, MAP3K1, MAP3K14, MAPK10, MCL1, MDM2, MYC, NFKB1, NFKBIA, PARP1, PRF1, RELA, RIPK1, TNF, TNFRSF1A, TNFRSF1B, TNFSF10, TP53, TRADD, TRAF1, TRAF2 40 APAF1(1), BIRC2(1), FAS(1), FASLG(1), MAP2K4(1), MCL1(1), MDM2(1), PARP1(1), PRF1(1), RELA(2), RIPK1(1), TNF(1), TRAF1(1), TRAF2(3) 14306727 17 14 17 6 3 4 2 5 3 0 0.620 1.000 1.000 493 ST_ERK1_ERK2_MAPK_PATHWAY The Erk1 and Erk2 MAP kinase pathways are regulated by Raf, Mos, and Tpl-2. ARAF1, ATF1, BAD, BRAF, COPEB, CREB1, CREB3, CREB5, DUSP4, DUSP6, DUSP9, EEF2K, EIF4E, GRB2, HTATIP, MAP2K1, MAP2K2, MAP3K8, MAPK1, MAPK3, MKNK1, MKNK2, MOS, NFKB1, RAP1A, RPS6KA1, RPS6KA2, RPS6KA3, SHC1, SOS1, SOS2, TRAF3 28 CREB3(1), EEF2K(2), GRB2(1), MAPK1(1), RPS6KA1(1), SHC1(2), SOS1(1) 10938948 9 9 9 5 5 3 0 0 1 0 0.765 1.000 1.000 494 RARRXRPATHWAY RXR and RAR suppress transcription in the absence of ligand and, on binding trans- or 9-cis-retinoic acid, are ubiquitinated to allow transcription to proceed. ERCC3, GTF2A1, GTF2B, GTF2E1, GTF2F1, HDAC3, NCOA1, NCOA2, NCOA3, NCOR2, PCAF, POLR2A, RARA, RXRA, TBP 14 ERCC3(1), NCOR2(2), POLR2A(2) 9772015 5 5 5 8 3 1 0 0 1 0 0.994 1.000 1.000 495 HSA00620_PYRUVATE_METABOLISM Genes involved in pyruvate metabolism ACACA, ACACB, ACAT1, ACAT2, ACOT12, ACSS1, ACSS2, ACYP1, ACYP2, AKR1B1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, DLAT, DLD, GLO1, GRHPR, HAGH, HAGHL, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, LDHD, MDH1, MDH2, ME1, ME2, ME3, PC, PCK1, PCK2, PDHA1, PDHA2, PDHB, PKLR, PKM2 42 ACACA(4), ACACB(2), ACAT1(1), ACOT12(1), ALDH1A3(1), ALDH3A1(1), ME1(2), ME3(1), PC(1), PCK2(2), PDHA2(2) 18264861 18 18 18 6 4 1 3 8 2 0 0.532 1.000 1.000 496 HSA04115_P53_SIGNALING_PATHWAY Genes involved in p53 signaling pathway APAF1, ATM, ATR, BAI1, BAX, BBC3, BID, CASP3, CASP8, CASP9, CCNB1, CCNB2, CCNB3, CCND1, CCND2, CCND3, CCNE1, CCNE2, CCNG1, CCNG2, CD82, CDC2, CDK2, CDK4, CDK6, CDKN1A, CDKN2A, CHEK1, CHEK2, CYCS, DDB2, EI24, FAS, GADD45A, GADD45B, GADD45G, GTSE1, IGF1, IGFBP3, LRDD, MDM2, MDM4, P53AIP1, PERP, PMAIP1, PPM1D, PTEN, RCHY1, RFWD2, RPRM, RRM2, RRM2B, SCOTIN, SERPINB5, SERPINE1, SESN1, SESN2, SESN3, SFN, SIAH1, STEAP3, THBS1, TNFRSF10B, TP53, TP53I3, TP73, TSC2, ZMAT3 62 APAF1(1), BAI1(4), CCND3(1), CCNE2(1), CCNG1(1), CCNG2(1), CDKN1A(2), CDKN2A(1), FAS(1), GTSE1(2), MDM2(1), MDM4(1), PPM1D(1), RCHY1(1), SERPINB5(2), SESN1(1), SESN2(2), SESN3(2), THBS1(2), TNFRSF10B(1), TSC2(2) 22513734 31 28 31 9 10 1 4 9 7 0 0.480 1.000 1.000 497 HIVNEFPATHWAY HIV-infected CD4 helper T cells may express Fas ligand, which binds to the Fas receptors of uninfected cells and induces apoptosis. ACTG1, ADPRT, APAF1, ARHGDIB, BAG4, BCL2, BID, BIRC2, BIRC3, BIRC4, CASP2, CASP3, CASP6, CASP7, CASP8, CASP9, CDC2L1, CDC2L2, CFLAR, CHUK, CRADD, CYCS, DAXX, DFFA, DFFB, FADD, GSN, LMNA, LMNB1, LMNB2, MAP2K7, MAP3K1, MAP3K14, MAP3K5, MAPK8, MDM2, NFKB1, NFKBIA, NUMA1, PAK2, PRKCD, PRKDC, PSEN1, PSEN2, PTK2, RASA1, RB1, RELA, RIPK1, SPTAN1, TNF, TNFRSF1A, TNFRSF1B, TNFRSF6, TNFSF6, TRADD, TRAF1, TRAF2 52 ACTG1(1), APAF1(1), ARHGDIB(1), BIRC2(1), DAXX(1), DFFA(1), GSN(1), LMNA(2), MAP2K7(2), MAP3K5(1), MDM2(1), NUMA1(1), PAK2(1), PRKDC(7), PTK2(2), RB1(2), RELA(2), RIPK1(1), TNF(1), TRAF1(1), TRAF2(3) 27020326 34 25 34 7 11 8 4 6 4 1 0.106 1.000 1.000 498 HSA04920_ADIPOCYTOKINE_SIGNALING_PATHWAY Genes involved in adipocytokine signaling pathway ACACB, ACSL1, ACSL3, ACSL4, ACSL5, ACSL6, ADIPOQ, ADIPOR1, ADIPOR2, AGRP, AKT1, AKT2, AKT3, CAMKK1, CAMKK2, CD36, CHUK, CPT1A, CPT1B, CPT1C, CPT2, FRAP1, G6PC, G6PC2, IKBKB, IKBKG, IRS1, IRS2, IRS4, JAK1, JAK2, JAK3, LEP, LEPR, MAPK10, MAPK8, MAPK9, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NPY, PCK1, PCK2, POMC, PPARA, PPARGC1A, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKAG1, PRKAG2, PRKAG3, PRKCQ, PTPN11, RELA, RXRA, RXRB, RXRG, SLC2A1, SLC2A4, SOCS3, STAT3, STK11, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF2, TYK2 70 ACACB(2), ACSL1(1), ACSL6(2), ADIPOR1(1), ADIPOR2(1), AKT1(1), AKT2(1), CPT1C(3), IRS1(2), IRS2(1), IRS4(3), JAK1(3), LEPR(1), PCK2(2), POMC(1), PPARA(2), PPARGC1A(2), PRKAA2(3), PRKAG1(2), PRKAG3(1), PRKCQ(1), RELA(2), RXRB(2), RXRG(1), STAT3(5), TNF(1), TRAF2(3), TYK2(1) 32535120 51 39 51 12 15 8 6 12 10 0 0.0939 1.000 1.000 499 STATIN_PATHWAY_PHARMGKB ABCA1, APOA1, APOA1, LOC440837, APOA4, APOC1, APOC2, APOC3, APOC3, LOC440838, APOE, CETP, CYP7A1, DGAT1, HMGCR, LCAT, LDLR, LIPC, LPL, LRP1, SCARB1, SOAT1 18 ABCA1(1), APOA4(1), CYP7A1(1), DGAT1(1), LDLR(1), LRP1(3), SCARB1(2) 10691879 10 10 10 6 5 2 1 1 1 0 0.814 1.000 1.000 500 INTRINSICPATHWAY The intrinsic prothrombin activation pathway is activated by traumatized blood vessels and induces clot formation. COL4A1, COL4A2, COL4A3, COL4A4, COL4A5, COL4A6, F10, F11, F12, F2, F2R, F5, F8, F9, FGA, FGB, FGG, KLKB1, KNG, PROC, PROS1, SERPINC1, SERPING1 22 COL4A1(1), COL4A2(2), COL4A3(1), COL4A4(1), COL4A5(1), F10(1), F11(2), F12(1), F2(1), F5(3), FGA(3), KLKB1(1), PROS1(2) 17263038 20 19 20 8 8 4 1 5 2 0 0.616 1.000 1.000 501 ST_DIFFERENTIATION_PATHWAY_IN_PC12_CELLS Rat-derived PC12 cells respond to nerve growth factor (NGF) and PACAP to differentiate into neuronal cells. AKT1, ASAH1, ATF1, BRAF, CAMP, CREB1, CREB3, CREB5, CREBBP, CRKL, DAG1, EGR1, EGR2, EGR3, EGR4, ELK1, FRS2, GAS, GNAQ, GRF2, JUN, MAP1B, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK3, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, NTRK1, OPN1LW, PACAP, PIK3C2G, PIK3CA, PIK3CD, PIK3R1, PTPN11, RPS6KA3, SH2B, SHC1, SRC, TERF2IP, TH, TUBA3 41 AKT1(1), ASAH1(1), CREB3(1), CREBBP(4), DAG1(1), EGR1(1), EGR3(1), FRS2(1), MAP1B(1), MAP2K4(1), MAP2K7(2), MAPK1(1), MAPK8IP3(2), NTRK1(3), PIK3CA(10), PIK3R1(1), SHC1(2), TERF2IP(1) 19541661 35 29 35 11 12 8 2 8 5 0 0.385 1.000 1.000 502 NFATPATHWAY Cardiac hypertrophy is induced by NF-ATc4 and GATA4, which are stimulated through calcineurin activated by CaMK. ACTA1, AGT, AKT1, CALM1, CALM2, CALM3, CALR, CAMK1, CAMK1G, CAMK4, CREBBP, CSNK1A1, CTF1, DTR, EDN1, ELSPBP1, F2, FGF2, FKBP1A, GATA4, GSK3B, HAND1, HAND2, HRAS, IGF1, LIF, MAP2K1, MAPK1, MAPK14, MAPK3, MAPK8, MEF2C, MYH2, NFATC1, NFATC2, NFATC3, NFATC4, NKX2-5, NPPA, PIK3CA, PIK3R1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RAF1, RPS6KB1, SYT1 51 AKT1(1), CAMK1(2), CAMK1G(1), CAMK4(2), CREBBP(4), F2(1), GSK3B(1), HRAS(3), MAPK1(1), MEF2C(2), MYH2(1), NFATC1(1), NFATC2(1), NPPA(1), PIK3CA(10), PIK3R1(1), PPP3CA(1), PPP3CC(1), PRKAR1A(1), PRKAR1B(1), RAF1(1), SYT1(1) 19838436 39 32 39 13 14 4 6 12 3 0 0.475 1.000 1.000 503 MCALPAINPATHWAY In integrin-mediated cell migration, calpains digest links between the actin cytoskeleton and focal adhesion proteins. ACTA1, CAPN1, CAPN2, CAPNS1, CAPNS2, CXCR3, EGF, EGFR, HRAS, ITGA1, ITGB1, MAPK1, MAPK3, MYL2, MYLK, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTK2, PXN, TLN1, VIL2 24 CAPNS1(1), EGFR(2), HRAS(3), MAPK1(1), MYLK(3), PRKAR1A(1), PRKAR1B(1), PTK2(2), PXN(1), TLN1(2) 12772709 17 16 17 9 6 1 2 7 1 0 0.849 1.000 1.000 504 P38MAPKPATHWAY The Rho family GTPases activate the p38 MAPKs under environmental stress or in the presence of pro-inflammatory cytokines. ATF2, CDC42, CREB1, DAXX, DDIT3, ELK1, GRB2, HMGN1, HRAS, HSPB1, HSPB2, MAP2K4, MAP2K6, MAP3K1, MAP3K5, MAP3K7, MAP3K9, MAPK14, MAPKAPK2, MAPKAPK5, MAX, MEF2A, MEF2B, MEF2C, MEF2D, MKNK1, MYC, PDZGEF1, PLA2G4A, RAC1, RIPK1, RPS6KA5, SHC1, STAT1, TGFB1, TGFB2, TGFB3, TGFBR1, TRADD, TRAF2 39 ATF2(1), DAXX(1), GRB2(1), HRAS(3), MAP2K4(1), MAP3K5(1), MAP3K7(2), MAP3K9(1), MAPKAPK5(1), MEF2A(1), MEF2C(2), MEF2D(1), PLA2G4A(2), RAC1(1), RIPK1(1), RPS6KA5(3), SHC1(2), STAT1(1), TGFB1(1), TGFB2(1), TGFBR1(2), TRAF2(3) 14279710 33 29 33 11 13 0 7 11 2 0 0.545 1.000 1.000 505 GLYCEROPHOSPHOLIPID_METABOLISM ACHE, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPS, CDIPT, CDS1, CDS2, CHAT, CHKA, CHKB, CHKB, CPT1B, CLC, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKQ, DGKZ, ETNK1, GNPAT, GPD1, GPD2, LCAT, LGALS13, LYPLA1, LYPLA2, LYPLA2, LYPLA2P1, LOC388499, LYPLA3, PAFAH1B1, PAFAH2, PCYT1A, PCYT1B, PEMT, PISD, PLA2G1B, PLA2G2A, PLA2G2E, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCB2, PLCG1, PLCG2, PPAP2A, PPAP2B, PPAP2C 49 ACHE(1), AGPAT2(1), AGPAT3(2), AGPAT4(1), CHAT(2), DGKA(1), DGKB(1), DGKD(2), DGKH(1), DGKQ(1), DGKZ(1), ETNK1(1), GNPAT(1), PLA2G2A(1), PLA2G4A(2), PLA2G6(1), PLCG1(1), PLCG2(1), PPAP2A(1), PPAP2B(1) 19567100 24 20 24 8 6 2 4 7 5 0 0.488 1.000 1.000 506 STRIATED_MUSCLE_CONTRACTION ACTA1, ACTA2, ACTC, ACTN2, ACTN3, ACTN4, C9orf97, DES, DES, FAM48A, DMD, MYBPC1, MYBPC2, MYBPC3, MYH3, MYH6, MYH6, MYH7, MYH8, MYL1, MYL2, MYL3, MYL4, MYL9, MYOM1, NEB, TCAP, TMOD1, TNNC2, TNNI1, TNNI2, TNNI3, TNNT1, TNNT2, TNNT3, TPM1, TPM2, TPM3, TPM4, TPM4, TTN, VIM 37 DMD(3), MYBPC1(1), MYBPC2(4), MYBPC3(2), MYH6(4), MYH7(4), MYH8(1), MYL1(1), MYOM1(2), NEB(5), TCAP(2), TPM1(1), TPM4(1), TTN(48) 52768572 79 61 79 15 26 9 12 20 11 1 0.0206 1.000 1.000 507 TRYPTOPHAN_METABOLISM AANAT, ABP1, ACAT1, ACAT2, ACMSD, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, AOC2, AOC3, AOX1, ASMT, CAT, CYP19A1, CYP1A1, CYP1A2, CYP2A6, CYP2A6, CYP2A7, CYP2A7P1, CYP2A13, CYP2B6, CYP2C18, CYP2C19, CYP2C19, CYP2C9, CYP2C8, CYP2C9, CYP2D6, CYP2E1, CYP2F1, CYP2J2, CYP3A4, CYP3A5, CYP3A7, CYP4B1, CYP4F8, CYP51A1, DDC, ECHS1, EHHADH, GCDH, HAAO, HADHA, INDO, KMO, KYNU, MAOA, MAOB, SDS, TDO2, TPH1, WARS, WARS2 54 ACAT1(1), ALDH1A1(1), ALDH1A2(3), ALDH1A3(1), ALDH3A1(1), AOC2(1), AOX1(1), ASMT(1), CAT(2), CYP19A1(2), CYP1A1(1), CYP1A2(1), CYP2A13(1), CYP2A6(2), CYP2B6(2), CYP2C18(1), CYP2C8(3), CYP2F1(2), CYP3A7(1), EHHADH(2), KMO(1), KYNU(2), TDO2(1), TPH1(1), WARS(1) 21455288 36 30 35 10 9 3 7 10 7 0 0.387 1.000 1.000 508 HSA05120_EPITHELIAL_CELL_SIGNALING_IN_HELICOBACTER_PYLORI_INFECTION Genes involved in epithelial cell signaling in Helicobacter pylori infection ADAM10, ADAM17, ATP6AP1, ATP6V0A1, ATP6V0A2, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0D1, ATP6V0D2, ATP6V0E1, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1E2, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, CASP3, CCL5, CDC42, CHUK, CSK, CXCL1, EGFR, F11R, GIT1, HBEGF, IGSF5, IKBKB, IKBKG, IL8, IL8RA, IL8RB, JAM2, JAM3, JUN, LYN, MAP2K4, MAP3K14, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK8, MAPK9, MET, NFKB1, NFKB2, NFKBIA, NOD1, PAK1, PLCG1, PLCG2, PTPN11, PTPRZ1, RAC1, RELA, SRC, TCIRG1, TJP1 65 ADAM10(1), ATP6V0A2(3), ATP6V1A(2), ATP6V1B1(1), ATP6V1C2(3), ATP6V1E2(1), ATP6V1F(1), ATP6V1H(1), EGFR(2), JAM2(1), MAP2K4(1), MET(1), NOD1(2), PLCG1(1), PLCG2(1), RAC1(1), RELA(2), TJP1(1) 27421272 26 23 26 8 3 4 5 12 2 0 0.531 1.000 1.000 509 HSA04720_LONG_TERM_POTENTIATION Genes involved in long-term potentiation ADCY1, ADCY8, ARAF, ATF4, BRAF, CACNA1C, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CHP, CREBBP, EP300, GNAQ, GRIA1, GRIA2, GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D, GRM1, GRM5, HRAS, ITPR1, ITPR2, ITPR3, KRAS, MAP2K1, MAP2K2, MAPK1, MAPK3, NRAS, PLCB1, PLCB2, PLCB3, PLCB4, PPP1CA, PPP1CB, PPP1CC, PPP1R12A, PPP1R1A, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, RAF1, RAP1A, RAP1B, RAPGEF3, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA6 66 ADCY1(1), ADCY8(4), ARAF(1), ATF4(1), CACNA1C(1), CALML6(1), CAMK2A(1), CAMK2D(1), CAMK4(2), CREBBP(4), EP300(4), GRIA1(4), GRIA2(2), GRIN1(1), GRIN2A(6), GRIN2B(3), GRIN2C(1), GRM1(2), GRM5(3), HRAS(3), ITPR1(2), ITPR2(3), ITPR3(1), MAPK1(1), PLCB1(2), PLCB4(3), PPP1CA(1), PPP1R1A(1), PPP3CA(1), PPP3CC(1), PRKACA(1), PRKCA(2), PRKCG(1), PRKX(2), RAF1(1), RPS6KA1(1), RPS6KA6(1) 38295875 71 60 70 19 25 9 4 19 14 0 0.200 1.000 1.000 510 HSA00640_PROPANOATE_METABOLISM Genes involved in propanoate metabolism ABAT, ACACA, ACACB, ACADM, ACAT1, ACAT2, ACSS1, ACSS2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH7A1, ALDH9A1, ECHS1, EHHADH, HADHA, HIBCH, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, LOC283398, MCEE, MLYCD, MUT, PCCA, PCCB, SUCLA2, SUCLG1, SUCLG2 33 ACACA(4), ACACB(2), ACAT1(1), ALDH1A3(1), ALDH3A1(1), EHHADH(2), MUT(1) 15482501 12 12 12 5 2 1 2 7 0 0 0.770 1.000 1.000 511 PYRIMIDINE_METABOLISM AK3, AK3L1, AK3L1, AK3L2, CAD, CANT1, CDA, CMPK, CTPS, CTPS2, DCK, DCTD, DHODH, DPYD, DPYS, DTYMK, DUT, ECGF1, ENTPD1, ITPA, NME1, NME2, NP, NT5C, NT5E, NT5M, NUDT2, POLA, POLB, POLD1, POLD2, POLE, POLG, POLL, POLQ, POLR1B, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLRMT, POLS, RRM1, RRM2, TK1, TK2, TXNRD1, TYMS, UCK1, UCK2, UMPS, UNG, UPB1, UPP1 55 CAD(1), CANT1(2), CTPS2(1), DHODH(1), DPYD(2), DPYS(1), NT5M(1), POLD1(1), POLE(2), POLG(1), POLL(1), POLQ(3), POLR1B(1), POLR2A(2), TXNRD1(1), UCK2(1), UMPS(1), UPP1(2) 22426804 25 21 24 9 9 2 7 4 3 0 0.493 1.000 1.000 512 HSA03022_BASAL_TRANSCRIPTION_FACTORS Genes involved in basal transcription factors GTF2A1, GTF2A1L, GTF2A2, GTF2B, GTF2E1, GTF2E2, GTF2F1, GTF2F2, GTF2H1, GTF2H2, GTF2H3, GTF2H4, GTF2I, GTF2IRD1, LOC391764, STON1, TAF1, TAF10, TAF12, TAF13, TAF1L, TAF2, TAF4, TAF4B, TAF5, TAF5L, TAF6, TAF6L, TAF7, TAF7L, TAF9, TAF9B, TBPL1, TBPL2 32 GTF2E2(1), STON1(1), TAF1(1), TAF1L(3), TAF5(1), TAF7L(2) 14006924 9 8 9 8 3 2 1 2 1 0 0.988 1.000 1.000 513 HSA04330_NOTCH_SIGNALING_PATHWAY Genes involved in Notch signaling pathway ADAM17, APH1A, CIR, CREBBP, CTBP1, CTBP2, DLL1, DLL3, DLL4, DTX1, DTX2, DTX3, DTX3L, DTX4, DVL1, DVL2, DVL3, EP300, GCN5L2, HDAC1, HDAC2, HES1, JAG1, JAG2, LFNG, LOC652788, MAML1, MAML2, MAML3, MFNG, NCOR2, NCSTN, NOTCH1, NOTCH2, NOTCH3, NOTCH4, NUMB, NUMBL, PCAF, PSEN1, PSEN2, PSENEN, PTCRA, RBPJ, RBPJL, RFNG, SNW1 43 CREBBP(4), CTBP2(1), DLL3(3), DLL4(1), DTX1(2), DTX2(1), DTX4(1), DVL2(2), EP300(4), JAG2(3), LFNG(1), MAML1(1), MAML2(1), MAML3(1), MFNG(1), NCOR2(2), NOTCH1(2), NOTCH2(4), NOTCH3(3), NOTCH4(2), NUMB(1), NUMBL(1), RBPJL(1), SNW1(2) 27410238 45 36 45 12 15 7 6 7 10 0 0.191 1.000 1.000 514 HSA04662_B_CELL_RECEPTOR_SIGNALING_PATHWAY Genes involved in B cell receptor signaling pathway AKT1, AKT2, AKT3, BCL10, BLNK, BTK, CARD11, CD19, CD22, CD72, CD79A, CD79B, CD81, CHP, CHUK, CR2, FCGR2B, FOS, GSK3B, HRAS, IFITM1, IKBKB, IKBKG, INPP5D, JUN, KRAS, LILRB3, LYN, MALT1, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NRAS, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG2, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKCB1, PTPN6, RAC1, RAC2, RAC3, RASGRP3, SYK, VAV1, VAV2, VAV3 62 AKT1(1), AKT2(1), BTK(1), CARD11(1), CD81(1), GSK3B(1), HRAS(3), INPP5D(2), NFATC1(1), NFATC2(1), PIK3CA(10), PIK3CB(1), PIK3CG(3), PIK3R1(1), PIK3R2(2), PIK3R3(1), PLCG2(1), PPP3CA(1), PPP3CC(1), RAC1(1), RAC2(1), SYK(2), VAV1(3), VAV2(1), VAV3(1) 29137160 43 38 43 12 15 4 8 13 3 0 0.220 1.000 1.000 515 HSA04370_VEGF_SIGNALING_PATHWAY Genes involved in VEGF signaling pathway AKT1, AKT2, AKT3, BAD, CASP9, CDC42, CHP, HRAS, KDR, KRAS, MAP2K1, MAP2K2, MAPK1, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPKAPK2, MAPKAPK3, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NOS3, NRAS, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCG1, PLCG2, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKCA, PRKCB1, PRKCG, PTGS2, PTK2, PXN, RAC1, RAC2, RAC3, RAF1, SH2D2A, SHC2, SPHK1, SPHK2, SRC, VEGFA 69 AKT1(1), AKT2(1), HRAS(3), KDR(3), MAPK1(1), MAPKAPK3(1), NFATC1(1), NFATC2(1), NOS3(1), PIK3CA(10), PIK3CB(1), PIK3CG(3), PIK3R1(1), PIK3R2(2), PIK3R3(1), PLA2G12B(1), PLA2G2A(1), PLA2G4A(2), PLA2G6(1), PLCG1(1), PLCG2(1), PPP3CA(1), PPP3CC(1), PRKCA(2), PRKCG(1), PTGS2(2), PTK2(2), PXN(1), RAC1(1), RAC2(1), RAF1(1), SHC2(1), SPHK2(1), VEGFA(2) 28268470 55 40 55 14 18 8 9 13 7 0 0.128 1.000 1.000 516 HSA04070_PHOSPHATIDYLINOSITOL_SIGNALING_SYSTEM Genes involved in phosphatidylinositol signaling system CALM1, CALM2, CALM3, CALML3, CALML6, CARKL, CDIPT, CDS1, CDS2, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKI, DGKQ, DGKZ, FN3K, IMPA1, IMPA2, INPP1, INPP4A, INPP4B, INPP5A, INPP5B, INPP5D, INPP5E, INPPL1, ITGB1BP3, ITPK1, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, OCRL, PI4KA, PI4KB, PIB5PA, PIK3C2A, PIK3C2B, PIK3C2G, PIK3C3, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIP4K2A, PIP4K2B, PIP4K2C, PIP5K1A, PIP5K1B, PIP5K1C, PIP5K3, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCD3, PLCD4, PLCE1, PLCG1, PLCG2, PLCZ1, PRKCA, PRKCB1, PRKCG, PTEN, PTPMT1, SKIP, SYNJ1, SYNJ2 72 CALML6(1), DGKA(1), DGKB(1), DGKD(2), DGKH(1), DGKI(2), DGKQ(1), DGKZ(1), IMPA1(1), INPP5B(1), INPP5D(2), ITPK1(2), ITPKB(2), ITPR1(2), ITPR2(3), ITPR3(1), OCRL(1), PI4KA(2), PI4KB(2), PIK3C2A(1), PIK3C2B(2), PIK3CA(10), PIK3CB(1), PIK3CG(3), PIK3R1(1), PIK3R2(2), PIK3R3(1), PIP5K1C(2), PLCB1(2), PLCB4(3), PLCD3(1), PLCD4(1), PLCE1(2), PLCG1(1), PLCG2(1), PLCZ1(2), PRKCA(2), PRKCG(1), SYNJ1(3), SYNJ2(2) 48445546 73 54 73 16 20 16 9 18 10 0 0.0343 1.000 1.000 517 HSA04060_CYTOKINE_CYTOKINE_RECEPTOR_INTERACTION Genes involved in cytokine-cytokine receptor interaction ACVR1, ACVR1B, ACVR2A, ACVR2B, AMH, AMHR2, BMP2, BMP7, BMPR1A, BMPR1B, BMPR2, CCL1, CCL11, CCL13, CCL14, CCL15, CCL16, CCL17, CCL18, CCL19, CCL2, CCL20, CCL21, CCL22, CCL23, CCL24, CCL25, CCL26, CCL27, CCL28, CCL3, CCL4, CCL5, CCL7, CCL8, CCR1, CCR2, CCR3, CCR4, CCR5, CCR6, CCR7, CCR8, CCR9, CD27, CD40, CD40LG, CD70, CLCF1, CNTF, CNTFR, CRLF2, CSF1, CSF1R, CSF2, CSF2RA, CSF2RB, CSF3, CSF3R, CTF1, CX3CL1, CX3CR1, CXCL1, CXCL10, CXCL11, CXCL12, CXCL13, CXCL14, CXCL16, CXCL2, CXCL3, CXCL5, CXCL6, CXCL9, CXCR3, CXCR4, CXCR6, EDA, EDA2R, EDAR, EGF, EGFR, EPO, EPOR, FAS, FASLG, FLJ78302, FLT1, FLT3, FLT3LG, FLT4, GDF5, GH1, GH2, GHR, HGF, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IFNE1, IFNG, IFNGR1, IFNGR2, IFNK, IFNW1, IL10, IL10RA, IL10RB, IL11, IL11RA, IL12A, IL12B, IL12RB1, IL12RB2, IL13, IL13RA1, IL15, IL15RA, IL17A, IL17B, IL17RA, IL17RB, IL18, IL18R1, IL18RAP, IL19, IL1A, IL1B, IL1R1, IL1R2, IL1RAP, IL2, IL20, IL20RA, IL21, IL21R, IL22, IL22RA1, IL22RA2, IL23A, IL23R, IL24, IL25, IL26, IL28A, IL28B, IL28RA, IL29, IL2RA, IL2RB, IL2RG, IL3, IL3RA, IL4, IL4R, IL5, IL5RA, IL6, IL6R, IL6ST, IL7, IL7R, IL8, IL8RA, IL8RB, IL9, IL9R, INHBA, INHBB, INHBC, INHBE, KDR, KIT, KITLG, LEP, LEPR, LIF, LIFR, LOC728045, LTA, LTB, LTBR, MET, MPL, NGFR, OSM, OSMR, PDGFB, PDGFC, PDGFRA, PDGFRB, PF4, PF4V1, PLEKHO2, PPBP, PRL, PRLR, RELT, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TNF, TNFRSF10A, TNFRSF10B, TNFRSF10C, TNFRSF10D, TNFRSF11A, TNFRSF11B, TNFRSF12A, TNFRSF13B, TNFRSF13C, TNFRSF14, TNFRSF17, TNFRSF18, TNFRSF19, TNFRSF1A, TNFRSF1B, TNFRSF21, TNFRSF25, TNFRSF4, TNFRSF6B, TNFRSF8, TNFRSF9, TNFSF10, TNFSF11, TNFSF12, TNFSF13, TNFSF13B, TNFSF14, TNFSF15, TNFSF18, TNFSF4, TNFSF8, TNFSF9, TPO, TSLP, VEGFA, VEGFB, VEGFC, XCL1, XCL2, XCR1 251 ACVR1B(1), ACVR2A(1), BMP7(3), BMPR2(1), CCL17(1), CCL28(1), CCL7(1), CCR2(1), CCR4(1), CCR6(1), CCR7(1), CCR9(1), CD27(1), CNTF(1), CSF1R(2), CSF2RA(2), CSF3R(1), CXCL16(1), CXCL9(1), CXCR6(1), EGFR(2), FAS(1), FASLG(1), FLT1(2), FLT3(1), FLT4(2), GH2(1), GHR(1), HGF(2), IFNA10(1), IFNA13(1), IFNA16(1), IFNW1(1), IL10RA(2), IL11RA(1), IL12A(1), IL12RB2(1), IL13RA1(1), IL17A(1), IL17RA(2), IL1RAP(2), IL20(1), IL20RA(1), IL21(1), IL21R(1), IL25(1), IL3RA(1), IL4(1), IL4R(2), IL6(1), IL6ST(2), IL7(1), IL7R(1), IL9(1), INHBA(2), INHBC(1), INHBE(1), KDR(3), LEPR(1), LIFR(1), LTBR(2), MET(1), PDGFRA(2), PDGFRB(1), PF4(1), TGFB1(1), TGFB2(1), TGFBR1(2), TNF(1), TNFRSF10A(1), TNFRSF10B(1), TNFRSF11B(2), TNFRSF13B(2), TNFRSF18(1), TNFRSF21(1), TNFRSF4(1), TNFRSF6B(1), TNFSF11(1), TNFSF12(1), TNFSF14(1), TNFSF8(1), TPO(1), VEGFA(2), XCL1(1), XCR1(1) 69297217 107 72 107 24 26 14 17 30 20 0 0.0128 1.000 1.000 518 HSA04910_INSULIN_SIGNALING_PATHWAY Genes involved in insulin signaling pathway ACACA, ACACB, AKT1, AKT2, AKT3, ARAF, BAD, BRAF, CALM1, CALM2, CALM3, CALML3, CALML6, CBL, CBLB, CBLC, CRK, CRKL, EIF4EBP1, ELK1, EXOC7, FASN, FBP1, FBP2, FLOT1, FLOT2, FOXO1, FRAP1, G6PC, G6PC2, GCK, GRB2, GSK3B, GYS1, GYS2, HRAS, IKBKB, INPP5D, INS, INSR, IRS1, IRS2, IRS4, KIAA1303, KRAS, LIPE, MAP2K1, MAP2K2, MAPK1, MAPK10, MAPK3, MAPK8, MAPK9, MKNK1, MKNK2, NRAS, PCK1, PCK2, PDE3A, PDE3B, PDPK1, PFKL, PFKM, PFKP, PHKA1, PHKA2, PHKB, PHKG1, PHKG2, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PKLR, PKM2, PPARGC1A, PPP1CA, PPP1CB, PPP1CC, PPP1R3A, PPP1R3B, PPP1R3C, PPP1R3D, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKACA, PRKACB, PRKACG, PRKAG1, PRKAG2, PRKAG3, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCI, PRKCZ, PRKX, PRKY, PTPN1, PTPRF, PYGB, PYGL, PYGM, RAF1, RAPGEF1, RHEB, RHOQ, RPS6, RPS6KB1, RPS6KB2, SH2B2, SHC1, SHC2, SHC3, SHC4, SKIP, SLC2A4, SOCS1, SOCS2, SOCS3, SOCS4, SORBS1, SOS1, SOS2, SREBF1, TRIP10, TSC1, TSC2 130 ACACA(4), ACACB(2), AKT1(1), AKT2(1), ARAF(1), CALML6(1), CRK(1), FASN(1), GCK(3), GRB2(1), GSK3B(1), HRAS(3), INPP5D(2), IRS1(2), IRS2(1), IRS4(3), MAPK1(1), PCK2(2), PDE3B(1), PDPK1(1), PFKL(1), PFKM(1), PFKP(1), PHKA1(1), PHKA2(1), PHKB(2), PIK3CA(10), PIK3CB(1), PIK3CG(3), PIK3R1(1), PIK3R2(2), PIK3R3(1), PPARGC1A(2), PPP1CA(1), PPP1R3A(3), PPP1R3B(2), PRKAA2(3), PRKACA(1), PRKAG1(2), PRKAG3(1), PRKAR1A(1), PRKAR1B(1), PRKCZ(2), PRKX(2), PTPN1(1), PTPRF(2), PYGL(2), RAF1(1), RAPGEF1(3), RPS6KB2(1), SHC1(2), SHC2(1), SORBS1(2), SOS1(1), TSC2(2) 62220205 97 75 96 23 31 15 12 27 12 0 0.0237 1.000 1.000 519 SIG_CHEMOTAXIS Genes related to chemotaxis ACTR2, ACTR3, AKT1, AKT2, AKT3, ANGPTL2, ARHGAP1, ARHGAP4, ARHGEF11, BTK, CDC42, CFL1, CFL2, GDI1, GDI2, INPPL1, ITPR1, ITPR2, ITPR3, LIMK1, MYLK, MYLK2, P101-PI3K, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PDK1, PIK3CA, PIK3CD, PIK3CG, PIK3R1, PITX2, PPP1R13B, PTEN, RACGAP1, RHO, ROCK1, ROCK2, RPS4X, SAG, WASF1, WASL 43 ACTR3(1), AKT1(1), AKT2(1), ARHGEF11(2), BTK(1), CFL1(1), ITPR1(2), ITPR2(3), ITPR3(1), LIMK1(1), MYLK(3), MYLK2(2), PAK2(1), PDK1(1), PIK3CA(10), PIK3CG(3), PIK3R1(1), PITX2(1), PPP1R13B(1), RACGAP1(1), ROCK1(5), SAG(1) 27050583 44 38 43 14 9 5 6 13 11 0 0.671 1.000 1.000 520 HISTONE_METHYLTRANSFERASE Genes with HMT activity AOF2, KDM6A, ASH1L, ASH2L, C17orf79, CARM1, CTCFL, DOT1L, EED, EHMT1, EHMT2, EZH1, EZH2, FBXL10, FBXL11, FBXO11, HCFC1, HSF4, JMJD1A, JMJD1B, JMJD2A, JMJD2B, JMJD2C, JMJD2D, JMJD3, JMJD4, JMJD6, MEN1, MLL, MLL2, MLL3, MLL4, MLL5, NSD1, OGT, PAXIP1, PPP1CA, PPP1CB, PPP1CC, PRDM2, PRDM6, PRDM7, PRDM9, PRMT1, PRMT5, PRMT6, PRMT7, PRMT8, RBBP5, SATB1, SETD1A, SETD1B, SETD2, SETD7, SETD8, SETDB1, SETDB2, SETMAR, SMYD3, STK38, SUV39H1, SUV39H2, SUV420H1, SUV420H2, SUZ12, WHSC1, WHSC1L1 55 ASH1L(3), DOT1L(3), EED(1), EHMT2(1), EZH1(1), EZH2(1), JMJD4(1), KDM6A(6), MEN1(1), NSD1(1), OGT(1), PAXIP1(2), PPP1CA(1), PRDM2(1), PRDM9(2), PRMT1(1), PRMT5(2), PRMT8(1), RBBP5(2), SETD1A(2), SETD2(4), SETDB1(2), SETDB2(1), SUV420H2(1), WHSC1(1), WHSC1L1(3) 46385104 46 41 46 11 11 5 3 12 15 0 0.405 1.000 1.000 521 HSA00500_STARCH_AND_SUCROSE_METABOLISM Genes involved in starch and sucrose metabolism AGL, AMY1A, AMY1B, AMY1C, AMY2A, AMY2B, ASCC3, ASCC3L1, ATP13A2, DDX18, DDX19A, DDX23, DDX4, DDX41, DDX47, DDX50, DDX51, DDX52, DDX54, DDX55, DDX56, DHX58, ENPP1, ENPP3, ENTPD7, EP400, ERCC2, ERCC3, G6PC, G6PC2, GAA, GANC, GBA, GBA3, GBE1, GCK, GPI, GUSB, GYS1, GYS2, HK1, HK2, HK3, IFIH1, LYZL1, MGAM, MOV10L1, NUDT5, NUDT8, PGM1, PGM3, PYGB, PYGL, PYGM, RAD54B, RAD54L, RUVBL2, SETX, SI, SKIV2L2, SMARCA2, SMARCA5, TREH, UGDH, UGP2, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, UXS1 80 AGL(2), AMY2B(2), ASCC3(1), ATP13A2(1), DDX23(1), DDX47(3), DDX50(3), DDX56(1), ENPP1(2), ENPP3(1), ENTPD7(1), EP400(1), ERCC2(2), ERCC3(1), GAA(1), GANC(2), GBE1(2), GCK(3), HK2(1), HK3(2), MGAM(2), PGM1(1), PGM3(1), PYGL(2), RAD54L(1), RUVBL2(2), SETX(2), SI(1), SKIV2L2(3), SMARCA2(1), SMARCA5(3), TREH(1), UGDH(1), UGP2(1), UGT1A4(1), UGT1A7(1), UGT1A8(2), UGT1A9(1), UGT2A1(1), UGT2A3(1), UGT2B10(2), UGT2B11(2), UGT2B15(1), UGT2B17(1), UGT2B28(2), UGT2B7(1) 48260969 71 53 71 18 16 11 10 20 14 0 0.138 1.000 1.000 522 HSA04012_ERBB_SIGNALING_PATHWAY Genes involved in ErbB signaling pathway ABL1, ABL2, AKT1, AKT2, AKT3, ARAF, AREG, BAD, BRAF, BTC, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CBL, CBLB, CBLC, CDKN1A, CDKN1B, CRK, CRKL, EGF, EGFR, EIF4EBP1, ELK1, ERBB2, ERBB3, ERBB4, EREG, FRAP1, GAB1, GRB2, GSK3B, HBEGF, HRAS, JUN, KRAS, MAP2K1, MAP2K2, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK3, MAPK8, MAPK9, MYC, NCK1, NCK2, NRAS, NRG1, NRG2, NRG3, NRG4, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PLCG2, PRKCA, PRKCB1, PRKCG, PTK2, RAF1, RPS6KB1, RPS6KB2, SHC1, SHC2, SHC3, SHC4, SOS1, SOS2, SRC, STAT5A, STAT5B, TGFA 84 ABL1(4), AKT1(1), AKT2(1), ARAF(1), CAMK2A(1), CAMK2D(1), CDKN1A(2), CDKN1B(4), CRK(1), EGFR(2), ERBB2(1), ERBB3(2), ERBB4(1), GRB2(1), GSK3B(1), HRAS(3), MAP2K4(1), MAP2K7(2), MAPK1(1), NRG1(2), NRG2(1), NRG3(2), PAK2(1), PIK3CA(10), PIK3CB(1), PIK3CG(3), PIK3R1(1), PIK3R2(2), PIK3R3(1), PLCG1(1), PLCG2(1), PRKCA(2), PRKCG(1), PTK2(2), RAF1(1), RPS6KB2(1), SHC1(2), SHC2(1), SOS1(1), STAT5B(1) 39655449 69 51 69 22 24 10 8 13 14 0 0.390 1.000 1.000 523 HSA04514_CELL_ADHESION_MOLECULES Genes involved in cell adhesion molecules (CAMs) ALCAM, CADM1, CADM3, CD2, CD22, CD226, CD274, CD276, CD28, CD34, CD4, CD40, CD40LG, CD58, CD6, CD80, CD86, CD8A, CD8B, CD99, CDH1, CDH15, CDH2, CDH3, CDH4, CDH5, CLDN1, CLDN10, CLDN11, CLDN14, CLDN15, CLDN16, CLDN17, CLDN18, CLDN19, CLDN2, CLDN20, CLDN22, CLDN23, CLDN3, CLDN4, CLDN5, CLDN6, CLDN7, CLDN8, CLDN9, CNTN1, CNTN2, CNTNAP1, CNTNAP2, CTLA4, ESAM, F11R, GLG1, HLA-A, HLA-A29.1, HLA-B, HLA-C, HLA-DMA, HLA-DMB, HLA-DOA, HLA-DOB, HLA-DPA1, HLA-DPB1, HLA-DQA1, HLA-DQA2, HLA-DQB1, HLA-DQB2, HLA-DRA, HLA-DRB1, HLA-DRB3, HLA-DRB4, HLA-DRB5, HLA-E, HLA-F, HLA-G, ICAM1, ICAM2, ICAM3, ICOS, ICOSLG, ITGA4, ITGA6, ITGA8, ITGA9, ITGAL, ITGAM, ITGAV, ITGB1, ITGB2, ITGB7, ITGB8, JAM2, JAM3, L1CAM, MADCAM1, MAG, MPZ, MPZL1, NCAM1, NCAM2, NEGR1, NEO1, NFASC, NLGN1, NLGN2, NLGN3, NRCAM, NRXN1, NRXN2, NRXN3, OCLN, PDCD1, PDCD1LG2, PECAM1, PTPRC, PTPRF, PTPRM, PVR, PVRL1, PVRL2, PVRL3, SDC1, SDC2, SDC3, SDC4, SELE, SELL, SELP, SELPLG, SIGLEC1, SPN, VCAM1, VCAN 130 ALCAM(1), CADM1(1), CADM3(2), CD226(1), CD276(1), CD8A(1), CD8B(1), CDH1(4), CDH2(2), CDH3(3), CDH4(4), CDH5(5), CLDN15(1), CLDN23(1), CLDN9(2), CNTN2(1), CNTNAP1(5), ESAM(1), GLG1(1), HLA-DRA(1), HLA-F(1), HLA-G(1), ICAM3(1), ITGA6(2), ITGA9(2), ITGAL(3), ITGAM(2), ITGAV(2), ITGB2(2), ITGB8(1), JAM2(1), L1CAM(3), MADCAM1(1), MAG(1), NCAM1(1), NCAM2(3), NEGR1(1), NEO1(1), NFASC(1), NLGN1(1), NRCAM(2), NRXN1(2), NRXN2(2), NRXN3(2), PDCD1(1), PTPRC(3), PTPRF(2), PVRL1(1), SDC3(1), SELE(1), SELP(2), SELPLG(1), SIGLEC1(5), VCAM1(1), VCAN(3) 57683605 99 71 96 28 36 14 10 22 17 0 0.101 1.000 1.000 524 HSA00240_PYRIMIDINE_METABOLISM Genes involved in pyrimidine metabolism AICDA, AK3, CAD, CANT1, CDA, CMPK, CTPS, CTPS2, DCK, DCTD, DHODH, DPYD, DPYS, DTYMK, DUT, ECGF1, ENTPD1, ENTPD3, ENTPD4, ENTPD5, ENTPD6, ENTPD8, ITPA, NME1, NME2, NME4, NME6, NME7, NP, NT5C, NT5C1A, NT5C1B, NT5C2, NT5C3, NT5E, NT5M, NUDT2, PNPT1, POLA1, POLA2, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, POLE3, POLE4, POLR1A, POLR1B, POLR1C, POLR1D, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLR3A, POLR3B, POLR3G, POLR3GL, POLR3H, POLR3K, PRIM1, PRIM2, RFC5, RRM1, RRM2, RRM2B, TK1, TK2, TXNRD1, TXNRD2, TYMS, UCK1, UCK2, UMPS, UPB1, UPP1, UPP2, UPRT, ZNRD1 86 CAD(1), CANT1(2), CTPS2(1), DHODH(1), DPYD(2), DPYS(1), ENTPD6(2), NT5C1B(1), NT5C2(2), NT5M(1), POLA1(1), POLD1(1), POLD3(1), POLE(2), POLR1B(1), POLR1C(1), POLR2A(2), POLR3A(2), POLR3B(1), TXNRD1(1), UCK2(1), UMPS(1), UPP1(2) 31599877 31 27 30 10 11 4 7 4 5 0 0.386 1.000 1.000 525 HSA04670_LEUKOCYTE_TRANSENDOTHELIAL_MIGRATION Genes involved in Leukocyte transendothelial migration ACTN1, ACTN2, ACTN3, ACTN4, ARHGAP5, BCAR1, CD99, CDC42, CDH5, CLDN1, CLDN10, CLDN11, CLDN14, CLDN15, CLDN16, CLDN17, CLDN18, CLDN19, CLDN2, CLDN20, CLDN22, CLDN23, CLDN3, CLDN4, CLDN5, CLDN6, CLDN7, CLDN8, CLDN9, CTNNA1, CTNNA2, CTNNA3, CTNNB1, CTNND1, CXCL12, CXCR4, CYBA, CYBB, ESAM, EZR, F11R, GNAI1, GNAI2, GNAI3, GRLF1, ICAM1, ITGA4, ITGAL, ITGAM, ITGB1, ITGB2, ITK, JAM2, JAM3, MAPK11, MAPK12, MAPK13, MAPK14, MLLT4, MMP2, MMP9, MRCL3, MRLC2, MSN, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLPF, NCF1, NCF2, NCF4, NOX1, NOX3, OCLN, PECAM1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PLCG2, PRKCA, PRKCB1, PRKCG, PTK2, PTK2B, PTPN11, PXN, RAC1, RAC2, RAP1A, RAP1B, RAPGEF3, RAPGEF4, RASSF5, RHOA, RHOH, ROCK1, ROCK2, SIPA1, THY1, TXK, VASP, VAV1, VAV2, VAV3, VCAM1, VCL 109 BCAR1(1), CDH5(5), CLDN15(1), CLDN23(1), CLDN9(2), CTNNA2(4), CTNNA3(1), CYBB(1), ESAM(1), GNAI1(1), GNAI2(1), ITGAL(3), ITGAM(2), ITGB2(2), ITK(1), JAM2(1), MLLT4(1), MMP9(1), MSN(1), MYL5(1), NCF1(1), NCF2(2), NCF4(1), NOX3(1), PIK3CA(10), PIK3CB(1), PIK3CG(3), PIK3R1(1), PIK3R2(2), PIK3R3(1), PLCG1(1), PLCG2(1), PRKCA(2), PRKCG(1), PTK2(2), PXN(1), RAC1(1), RAC2(1), RAPGEF4(1), RASSF5(1), ROCK1(5), SIPA1(1), VAV1(3), VAV2(1), VAV3(1), VCAM1(1) 47943902 79 59 78 21 27 8 9 24 11 0 0.210 1.000 1.000 526 ST_INTEGRIN_SIGNALING_PATHWAY Integrins are transmembrane receptors that mediate cell growth, survival, and migration by binding to ligands in the extracellular matrix. ABL1, ACK1, ACTN1, ACTR2, ACTR3, AKT1, AKT2, AKT3, ANGPTL2, ARHGEF6, ARHGEF7, BCAR1, BRAF, CAV1, CDC42, CDKN2A, CRK, CSE1L, DDEF1, DOCK1, EPHB2, FYN, GRAF, GRB2, GRB7, GRF2, GRLF1, ILK, ITGA1, ITGA10, ITGA11, ITGA2, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGB3BP, MAP2K4, MAP2K7, MAP3K11, MAPK1, MAPK10, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MRAS, MYLK, MYLK2, P4HB, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PIK3CA, PIK3CB, PKLR, PLCG1, PLCG2, PTEN, PTK2, RAF1, RALA, RHO, ROCK1, ROCK2, SHC1, SOS1, SOS2, SRC, TERF2IP, TLN1, TLN2, VASP, WAS, ZYX 76 ABL1(4), ACTR3(1), AKT1(1), AKT2(1), ARHGEF6(1), BCAR1(1), CDKN2A(1), CRK(1), CSE1L(1), EPHB2(3), GRB2(1), GRB7(2), ITGA10(1), ITGA11(2), ITGA2(1), ITGA3(2), ITGA6(2), ITGA7(1), ITGA9(2), MAP2K4(1), MAP2K7(2), MAP3K11(2), MAPK1(1), MAPK8IP3(2), MRAS(1), MYLK(3), MYLK2(2), PAK2(1), PIK3CA(10), PIK3CB(1), PLCG1(1), PLCG2(1), PTK2(2), RAF1(1), ROCK1(5), SHC1(2), SOS1(1), TERF2IP(1), TLN1(2), TLN2(2) 46953063 73 52 72 19 18 11 9 22 13 0 0.196 1.000 1.000 527 HSA04660_T_CELL_RECEPTOR_SIGNALING_PATHWAY Genes involved in T cell receptor signaling pathway AKT1, AKT2, AKT3, BCL10, CARD11, CBL, CBLB, CBLC, CD247, CD28, CD3D, CD3E, CD3G, CD4, CD40LG, CD8A, CD8B, CDC42, CDK4, CHP, CHUK, CSF2, CTLA4, FOS, FYN, GRAP2, GRB2, HRAS, ICOS, IFNG, IKBKB, IKBKG, IL10, IL2, IL4, IL5, ITK, JUN, KRAS, LAT, LCK, LCP2, MALT1, MAP3K14, MAP3K8, NCK1, NCK2, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NRAS, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PDCD1, PDK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKCQ, PTPN6, PTPRC, RASGRP1, RHOA, SOS1, SOS2, TEC, TNF, VAV1, VAV2, VAV3, ZAP70 92 AKT1(1), AKT2(1), CARD11(1), CD8A(1), CD8B(1), GRB2(1), HRAS(3), IL4(1), ITK(1), NFATC1(1), NFATC2(1), PAK2(1), PDCD1(1), PDK1(1), PIK3CA(10), PIK3CB(1), PIK3CG(3), PIK3R1(1), PIK3R2(2), PIK3R3(1), PLCG1(1), PPP3CA(1), PPP3CC(1), PRKCQ(1), PTPRC(3), SOS1(1), TNF(1), VAV1(3), VAV2(1), VAV3(1), ZAP70(2) 39667724 50 41 50 15 17 6 8 16 3 0 0.288 1.000 1.000 528 HSA04210_APOPTOSIS Genes involved in apoptosis AIFM1, AKT1, AKT2, AKT3, APAF1, ATM, BAD, BAX, BCL2, BCL2L1, BID, BIRC2, BIRC3, BIRC4, CAPN1, CAPN2, CASP10, CASP3, CASP6, CASP7, CASP8, CASP9, CFLAR, CHP, CHUK, CSF2RB, CYCS, DFFA, DFFB, ENDOG, FADD, FAS, FASLG, IKBKB, IKBKG, IL1A, IL1B, IL1R1, IL1RAP, IL3, IL3RA, IRAK1, IRAK2, IRAK3, IRAK4, MAP3K14, MYD88, NFKB1, NFKB2, NFKBIA, NGFB, NTRK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKACA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RELA, RIPK1, TNF, TNFRSF10A, TNFRSF10B, TNFRSF10C, TNFRSF10D, TNFRSF1A, TNFSF10, TP53, TRADD, TRAF2 79 AKT1(1), AKT2(1), APAF1(1), BIRC2(1), DFFA(1), FAS(1), FASLG(1), IL1RAP(2), IL3RA(1), IRAK1(1), IRAK2(2), IRAK4(1), NTRK1(3), PIK3CA(10), PIK3CB(1), PIK3CG(3), PIK3R1(1), PIK3R2(2), PIK3R3(1), PPP3CA(1), PPP3CC(1), PRKACA(1), PRKAR1A(1), PRKAR1B(1), RELA(2), RIPK1(1), TNF(1), TNFRSF10A(1), TNFRSF10B(1), TRAF2(3) 29947312 49 39 49 17 11 10 7 16 5 0 0.504 1.000 1.000 529 PHOSPHATIDYLINOSITOL_SIGNALING_SYSTEM ACVR1, ACVR1B, ACVRL1, AKT1, AURKB, BMPR1A, BMPR2, BUB1, CDC2L5, CDIPT, CDKL1, CDKL2, CDS1, CDS2, CLK1, CLK2, CLK4, COL4A3BP, CSNK2A1, CSNK2A1, CSNK2A1P, CSNK2A2, CSNK2B, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKQ, DGKZ, IMPA1, INPP1, INPP4A, INPP4B, INPP5A, INPPL1, ITPKA, ITPKB, MAP3K10, MOS, NEK1, NEK3, OCRL, PAK4, PCTK1, PCTK2, PIK3C2A, PIK3C2B, PIK3C2G, PIK3CA, PIK3CB, PIK3CG, PIK4CA, PIK4CA, LOC220686, PIM2, PIP5K2B, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCG1, PLCG2, PLK3, PRKACA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCQ, PRKCZ, PRKD1, PRKG1, RAF1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA4, RPS6KB1, STK11, TGFBR1, VRK1 82 ACVR1B(1), ACVRL1(1), AKT1(1), AURKB(1), BMPR2(1), BUB1(1), CDKL2(3), CSNK2A2(1), DGKA(1), DGKB(1), DGKD(2), DGKH(1), DGKQ(1), DGKZ(1), IMPA1(1), ITPKB(2), MAP3K10(4), NEK1(2), OCRL(1), PIK3C2A(1), PIK3C2B(2), PIK3CA(10), PIK3CB(1), PIK3CG(3), PLCB1(2), PLCB4(3), PLCG1(1), PLCG2(1), PLK3(3), PRKACA(1), PRKAR1A(1), PRKAR1B(1), PRKCA(2), PRKCG(1), PRKCH(1), PRKCQ(1), PRKCZ(2), PRKD1(2), PRKG1(1), RAF1(1), RPS6KA1(1), RPS6KA4(2), TGFBR1(2) 44222274 73 50 73 19 19 14 14 18 8 0 0.107 1.000 1.000 530 HSA04110_CELL_CYCLE Genes involved in cell cycle ABL1, ANAPC1, ANAPC10, ANAPC11, ANAPC2, ANAPC4, ANAPC5, ANAPC7, ATM, ATR, BUB1, BUB1B, BUB3, CCNA1, CCNA2, CCNB1, CCNB2, CCNB3, CCND1, CCND2, CCND3, CCNE1, CCNE2, CCNH, CDC14A, CDC14B, CDC16, CDC2, CDC20, CDC23, CDC25A, CDC25B, CDC25C, CDC26, CDC27, CDC45L, CDC6, CDC7, CDK2, CDK4, CDK6, CDK7, CDKN1A, CDKN1B, CDKN1C, CDKN2A, CDKN2B, CDKN2C, CDKN2D, CHEK1, CHEK2, CREBBP, CUL1, DBF4, E2F1, E2F2, E2F3, EP300, ESPL1, FZR1, GADD45A, GADD45B, GADD45G, GSK3B, hCG_1982709, HDAC1, HDAC2, LOC440917, LOC728919, MAD1L1, MAD2L1, MAD2L2, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, MDM2, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, PKMYT1, PLK1, PRKDC, PTTG1, PTTG2, RB1, RBL1, RBL2, RBX1, SFN, SKP1, SKP2, SMAD2, SMAD3, SMAD4, SMC1A, SMC1B, TFDP1, TGFB1, TGFB2, TGFB3, TP53, WEE1, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ 107 ABL1(4), ANAPC1(1), ANAPC2(1), ANAPC5(3), BUB1(1), CCNA1(1), CCND3(1), CCNE2(1), CDC14B(2), CDC23(1), CDC25A(1), CDC25B(2), CDC6(1), CDC7(1), CDKN1A(2), CDKN1B(4), CDKN2A(1), CREBBP(4), E2F3(1), EP300(4), ESPL1(1), FZR1(2), GSK3B(1), MAD1L1(1), MAD2L1(1), MAD2L2(1), MCM3(1), MCM4(2), MCM5(1), MCM6(2), MCM7(1), MDM2(1), PRKDC(7), RB1(2), RBL2(1), SMAD2(1), SMAD3(1), SMAD4(4), SMC1B(1), TFDP1(1), TGFB1(1), TGFB2(1), YWHAH(1), YWHAQ(1) 50217775 74 53 74 17 20 6 13 19 15 1 0.123 1.000 1.000 531 HSA04630_JAK_STAT_SIGNALING_PATHWAY Genes involved in Jak-STAT signaling pathway AKT1, AKT2, AKT3, BCL2L1, CBL, CBLB, CBLC, CCND1, CCND2, CCND3, CISH, CLCF1, CNTF, CNTFR, CREBBP, CRLF2, CSF2, CSF2RA, CSF2RB, CSF3, CSF3R, CTF1, EP300, EPO, EPOR, GH1, GH2, GHR, GRB2, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IFNE1, IFNG, IFNGR1, IFNGR2, IFNK, IFNW1, IL10, IL10RA, IL10RB, IL11, IL11RA, IL12A, IL12B, IL12RB1, IL12RB2, IL13, IL13RA1, IL13RA2, IL15, IL15RA, IL19, IL2, IL20, IL20RA, IL21, IL21R, IL22, IL22RA1, IL22RA2, IL23A, IL23R, IL24, IL26, IL28A, IL28B, IL28RA, IL29, IL2RA, IL2RB, IL2RG, IL3, IL3RA, IL4, IL4R, IL5, IL5RA, IL6, IL6R, IL6ST, IL7, IL7R, IL9, IL9R, IRF9, JAK1, JAK2, JAK3, LEP, LEPR, LIF, LIFR, MPL, MYC, OSM, OSMR, PIAS1, PIAS2, PIAS3, PIAS4, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIM1, PRL, PRLR, PTPN11, PTPN6, SOCS1, SOCS2, SOCS3, SOCS4, SOCS5, SOCS7, SOS1, SOS2, SPRED1, SPRED2, SPRY1, SPRY2, SPRY3, SPRY4, STAM, STAM2, STAT1, STAT2, STAT3, STAT4, STAT5A, STAT5B, STAT6, TPO, TSLP, TYK2 151 AKT1(1), AKT2(1), CCND3(1), CNTF(1), CREBBP(4), CSF2RA(2), CSF3R(1), EP300(4), GH2(1), GHR(1), GRB2(1), IFNA10(1), IFNA13(1), IFNA16(1), IFNW1(1), IL10RA(2), IL11RA(1), IL12A(1), IL12RB2(1), IL13RA1(1), IL20(1), IL20RA(1), IL21(1), IL21R(1), IL3RA(1), IL4(1), IL4R(2), IL6(1), IL6ST(2), IL7(1), IL7R(1), IL9(1), JAK1(3), LEPR(1), LIFR(1), PIAS3(1), PIAS4(1), PIK3CA(10), PIK3CB(1), PIK3CG(3), PIK3R1(1), PIK3R2(2), PIK3R3(1), SOCS5(1), SOS1(1), SPRED2(1), SPRY3(1), STAT1(1), STAT3(5), STAT4(3), STAT5B(1), STAT6(2), TPO(1), TYK2(1) 56758984 85 62 85 25 18 13 15 23 16 0 0.239 1.000 1.000 532 HSA04620_TOLL_LIKE_RECEPTOR_SIGNALING_PATHWAY Genes involved in Toll-like receptor signaling pathway AKT1, AKT2, AKT3, CASP8, CCL3, CCL4, CCL5, CD14, CD40, CD80, CD86, CHUK, CXCL10, CXCL11, CXCL9, FADD, FOS, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IKBKB, IKBKE, IKBKG, IL12A, IL12B, IL1B, IL6, IL8, IRAK1, IRAK4, IRF3, IRF5, IRF7, JUN, LBP, LY96, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAP3K8, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK8, MAPK9, MYD88, NFKB1, NFKB2, NFKBIA, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, RAC1, RELA, RIPK1, SPP1, STAT1, TBK1, TICAM1, TICAM2, TIRAP, TLR1, TLR2, TLR3, TLR4, TLR5, TLR6, TLR7, TLR8, TLR9, TNF, TOLLIP, TRAF3, TRAF6 98 AKT1(1), AKT2(1), CXCL9(1), IFNA10(1), IFNA13(1), IFNA16(1), IL12A(1), IL6(1), IRAK1(1), IRAK4(1), IRF3(2), MAP2K4(1), MAP2K7(2), MAP3K7(2), MAPK1(1), PIK3CA(10), PIK3CB(1), PIK3CG(3), PIK3R1(1), PIK3R2(2), PIK3R3(1), RAC1(1), RELA(2), RIPK1(1), STAT1(1), TLR7(1), TLR9(1), TNF(1) 35090378 44 35 44 15 12 7 9 10 6 0 0.416 1.000 1.000 533 HSA04510_FOCAL_ADHESION Genes involved in focal adhesion ACTB, ACTG1, ACTN1, ACTN2, ACTN3, ACTN4, AKT1, AKT2, AKT3, ARHGAP5, BAD, BCAR1, BCL2, BIRC2, BIRC3, BIRC4, BRAF, CAPN2, CAV1, CAV2, CAV3, CCND1, CCND2, CCND3, CDC42, CHAD, COL11A1, COL11A2, COL1A1, COL1A2, COL2A1, COL3A1, COL4A1, COL4A2, COL4A4, COL4A6, COL5A1, COL5A2, COL5A3, COL6A1, COL6A2, COL6A3, COL6A6, COMP, CRK, CRKL, CTNNB1, DIAPH1, DOCK1, EGF, EGFR, ELK1, ERBB2, FARP2, FIGF, FLNA, FLNB, FLNC, FLT1, FN1, FYN, GRB2, GRLF1, GSK3B, HGF, HRAS, IBSP, IGF1, IGF1R, ILK, ITGA1, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAV, ITGB1, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, JUN, KDR, LAMA1, LAMA2, LAMA3, LAMA4, LAMA5, LAMB1, LAMB2, LAMB3, LAMB4, LAMC1, LAMC2, LAMC3, LOC653852, MAP2K1, MAPK1, MAPK10, MAPK3, MAPK8, MAPK9, MET, MLCK, MRCL3, MRLC2, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLK, MYLK2, MYLPF, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PARVA, PARVB, PARVG, PDGFA, PDGFB, PDGFC, PDGFD, PDGFRA, PDGFRB, PDPK1, PGF, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIP5K1C, PPP1CA, PPP1CB, PPP1CC, PPP1R12A, PRKCA, PRKCB1, PRKCG, PTEN, PTK2, PXN, RAC1, RAC2, RAC3, RAF1, RAP1A, RAP1B, RAPGEF1, RELN, RHOA, ROCK1, ROCK2, SHC1, SHC2, SHC3, SHC4, SOS1, SOS2, SPP1, SRC, THBS1, THBS2, THBS3, THBS4, TLN1, TLN2, TNC, TNN, TNR, TNXB, VASP, VAV1, VAV2, VAV3, VCL, VEGFA, VEGFB, VEGFC, VTN, VWF, ZYX 189 ACTG1(1), AKT1(1), AKT2(1), BCAR1(1), BIRC2(1), CAV3(1), CCND3(1), COL11A1(7), COL11A2(4), COL1A1(3), COL1A2(1), COL3A1(2), COL4A1(1), COL4A2(2), COL4A4(1), COL5A1(3), COL5A3(2), COL6A1(2), COL6A3(5), COL6A6(2), COMP(1), CRK(1), DIAPH1(1), EGFR(2), ERBB2(1), FLNC(1), FLT1(2), FN1(2), GRB2(1), GSK3B(1), HGF(2), HRAS(3), IGF1R(1), ITGA10(1), ITGA11(2), ITGA2(1), ITGA2B(3), ITGA3(2), ITGA6(2), ITGA7(1), ITGA9(2), ITGAV(2), ITGB4(2), ITGB5(1), ITGB6(2), ITGB8(1), KDR(3), LAMA1(3), LAMA2(3), LAMA3(4), LAMA4(4), LAMA5(1), LAMB1(4), LAMB2(2), LAMB3(1), LAMB4(1), LAMC1(3), LAMC2(1), LAMC3(1), MAPK1(1), MET(1), MYL5(1), MYLK(3), MYLK2(2), PAK2(1), PARVB(1), PARVG(2), PDGFRA(2), PDGFRB(1), PDPK1(1), PIK3CA(10), PIK3CB(1), PIK3CG(3), PIK3R1(1), PIK3R2(2), PIK3R3(1), PIP5K1C(2), PPP1CA(1), PRKCA(2), PRKCG(1), PTK2(2), PXN(1), RAC1(1), RAC2(1), RAF1(1), RAPGEF1(3), RELN(3), ROCK1(5), SHC1(2), SHC2(1), SOS1(1), THBS1(2), THBS4(1), TLN1(2), TLN2(2), TNC(2), TNN(2), TNXB(7), VAV1(3), VAV2(1), VAV3(1), VEGFA(2), VWF(4) 143688844 204 123 203 66 73 28 18 58 27 0 0.136 1.000 1.000 534 HSA04080_NEUROACTIVE_LIGAND_RECEPTOR_INTERACTION Genes involved in neuroactive ligand-receptor interaction ADCYAP1R1, ADORA1, ADORA2A, ADORA2B, ADORA3, ADRA1A, ADRA1B, ADRA2A, ADRA2B, ADRA2C, ADRB1, ADRB2, ADRB3, AGTR1, AGTR2, AGTRL1, AVPR1A, AVPR1B, AVPR2, BDKRB1, BDKRB2, BRS3, C3AR1, C5AR1, CALCR, CALCRL, CCKAR, CCKBR, CGA, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, CNR1, CNR2, CRHR1, CRHR2, CTSG, CYSLTR1, CYSLTR2, DRD1, DRD2, DRD3, DRD4, DRD5, EDG1, EDG2, EDG3, EDG4, EDG5, EDG6, EDG7, EDG8, EDNRA, EDNRB, F2, F2R, F2RL1, F2RL2, F2RL3, FPR1, FPRL1, FPRL2, FSHB, FSHR, GABBR1, GABBR2, GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GABRB1, GABRB2, GABRB3, GABRD, GABRE, GABRG1, GABRG2, GABRG3, GABRP, GABRQ, GABRR1, GABRR2, GALR1, GALR2, GALR3, GCGR, GH1, GH2, GHR, GHRHR, GHSR, GIPR, GLP1R, GLP2R, GLRA1, GLRA2, GLRA3, GLRB, GNRHR, GPR156, GPR23, GPR35, GPR50, GPR63, GPR83, GRIA1, GRIA2, GRIA3, GRIA4, GRID1, GRID2, GRIK1, GRIK2, GRIK3, GRIK4, GRIK5, GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D, GRIN3A, GRIN3B, GRM1, GRM2, GRM3, GRM4, GRM5, GRM6, GRM7, GRM8, GRPR, GZMA, HCRTR1, HCRTR2, HRH1, HRH2, HRH3, HRH4, HTR1A, HTR1B, HTR1D, HTR1E, HTR1F, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, KISS1R, LEP, LEPR, LHB, LHCGR, LTB4R, LTB4R2, MAS1, MC1R, MC2R, MC3R, MC4R, MC5R, MCHR1, MCHR2, MLNR, MTNR1A, MTNR1B, NMBR, NMUR1, NMUR2, NPBWR1, NPBWR2, NPFFR1, NPFFR2, NPY1R, NPY2R, NPY5R, NR3C1, NTSR1, NTSR2, OPRD1, OPRK1, OPRL1, OPRM1, OXTR, P2RX1, P2RX2, P2RX3, P2RX4, P2RX5, P2RX7, P2RXL1, P2RY1, P2RY10, P2RY11, P2RY13, P2RY14, P2RY2, P2RY4, P2RY5, P2RY6, P2RY8, PARD3, PPYR1, PRL, PRLHR, PRLR, PRSS1, PRSS2, PRSS3, PTAFR, PTGDR, PTGER1, PTGER2, PTGER3, PTGER4, PTGFR, PTGIR, PTH2R, PTHR1, RXFP1, RXFP2, SCTR, SSTR1, SSTR2, SSTR3, SSTR4, SSTR5, TAAR1, TAAR2, TAAR5, TAAR6, TAAR8, TAAR9, TACR1, TACR2, TACR3, TBXA2R, THRA, THRB, TRHR, TRPV1, TSHB, TSHR, TSPO, UTS2R, VIPR1, VIPR2 236 ADCYAP1R1(2), ADORA1(2), ADORA2A(1), ADORA3(1), ADRA1A(1), ADRA1B(2), ADRA2A(2), ADRA2C(1), ADRB1(1), AGTR1(2), AVPR1B(1), BDKRB1(1), BRS3(1), C3AR1(1), CCKAR(2), CCKBR(1), CHRM4(1), CNR1(2), CYSLTR2(1), DRD2(1), DRD3(1), F2(1), FPR1(1), FSHR(1), GABBR2(1), GABRA3(1), GABRA5(1), GABRB1(4), GABRB2(2), GABRD(1), GABRE(2), GABRG1(4), GABRP(1), GABRQ(1), GABRR1(1), GABRR2(2), GH2(1), GHR(1), GLP2R(1), GLRA1(2), GLRA2(2), GNRHR(3), GPR156(2), GPR35(1), GPR50(2), GPR83(1), GRIA1(4), GRIA2(2), GRIA3(1), GRIA4(2), GRID1(2), GRID2(5), GRIK1(2), GRIK2(1), GRIK3(1), GRIK4(2), GRIK5(1), GRIN1(1), GRIN2A(6), GRIN2B(3), GRIN2C(1), GRIN3A(1), GRIN3B(1), GRM1(2), GRM3(1), GRM4(1), GRM5(3), GRM7(1), GRM8(1), GZMA(1), HCRTR2(3), HTR1A(2), HTR1D(1), HTR1E(2), HTR2A(2), HTR2B(1), HTR2C(2), HTR4(1), HTR5A(1), HTR6(2), LEPR(1), LHCGR(1), MAS1(1), MC3R(1), MCHR1(1), MCHR2(1), MTNR1A(1), MTNR1B(1), NMUR1(1), NMUR2(1), NPY1R(1), NPY2R(1), NTSR1(1), P2RY1(1), P2RY10(1), P2RY14(1), P2RY4(2), P2RY6(1), P2RY8(1), PTGIR(1), PTH2R(1), RXFP1(2), RXFP2(1), SCTR(1), SSTR1(1), SSTR2(1), SSTR3(1), SSTR5(1), TAAR5(1), TAAR6(1), TAAR8(1), TACR1(1), TACR3(1), TBXA2R(2), THRA(2), TRHR(1), TSHR(1), VIPR1(1) 86712491 173 117 170 50 79 19 11 41 23 0 0.00595 1.000 1.000 535 HSA04020_CALCIUM_SIGNALING_PATHWAY Genes involved in calcium signaling pathway ADCY1, ADCY2, ADCY3, ADCY4, ADCY7, ADCY8, ADCY9, ADORA2A, ADORA2B, ADRA1A, ADRA1B, ADRA1D, ADRB1, ADRB2, ADRB3, AGTR1, ATP2A1, ATP2A2, ATP2A3, ATP2B1, ATP2B2, ATP2B3, ATP2B4, AVPR1A, AVPR1B, BDKRB1, BDKRB2, BST1, CACNA1A, CACNA1B, CACNA1C, CACNA1D, CACNA1E, CACNA1F, CACNA1G, CACNA1H, CACNA1I, CACNA1S, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CCKAR, CCKBR, CD38, CHP, CHRM1, CHRM2, CHRM3, CHRM5, CHRNA7, CYSLTR1, CYSLTR2, DRD1, EDNRA, EDNRB, EGFR, ERBB2, ERBB3, ERBB4, F2R, GNA11, GNA14, GNA15, GNAL, GNAQ, GNAS, GRIN1, GRIN2A, GRIN2C, GRIN2D, GRM1, GRM5, GRPR, HRH1, HRH2, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, LHCGR, LTB4R2, MLCK, MYLK, MYLK2, NOS1, NOS2A, NOS3, NTSR1, OXTR, P2RX1, P2RX2, P2RX3, P2RX4, P2RX5, P2RX7, P2RXL1, PDE1A, PDE1B, PDE1C, PDGFRA, PDGFRB, PHKA1, PHKA2, PHKB, PHKG1, PHKG2, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCD3, PLCD4, PLCE1, PLCG1, PLCG2, PLCZ1, PLN, PPID, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, PTAFR, PTGER1, PTGER3, PTGFR, PTK2B, RYR1, RYR2, RYR3, SLC25A4, SLC25A5, SLC25A6, SLC8A1, SLC8A2, SLC8A3, SPHK1, SPHK2, TACR1, TACR2, TACR3, TBXA2R, TNNC1, TNNC2, TRHR, TRPC1, VDAC1, VDAC2, VDAC3 168 ADCY1(1), ADCY3(1), ADCY4(2), ADCY8(4), ADCY9(2), ADORA2A(1), ADRA1A(1), ADRA1B(2), ADRA1D(2), ADRB1(1), AGTR1(2), ATP2A1(1), ATP2A2(1), ATP2B1(1), ATP2B2(4), ATP2B3(2), ATP2B4(4), AVPR1B(1), BDKRB1(1), CACNA1A(8), CACNA1C(1), CACNA1D(2), CACNA1E(7), CACNA1F(1), CACNA1G(1), CACNA1H(2), CACNA1I(1), CACNA1S(2), CALML6(1), CAMK2A(1), CAMK2D(1), CAMK4(2), CCKAR(2), CCKBR(1), CD38(1), CYSLTR2(1), EGFR(2), ERBB2(1), ERBB3(2), ERBB4(1), GNAL(1), GNAS(2), GRIN1(1), GRIN2A(6), GRIN2C(1), GRM1(2), GRM5(3), HTR2A(2), HTR2B(1), HTR2C(2), HTR4(1), HTR5A(1), HTR6(2), ITPKB(2), ITPR1(2), ITPR2(3), ITPR3(1), LHCGR(1), MYLK(3), MYLK2(2), NOS1(2), NOS3(1), NTSR1(1), PDE1B(1), PDE1C(1), PDGFRA(2), PDGFRB(1), PHKA1(1), PHKA2(1), PHKB(2), PLCB1(2), PLCB4(3), PLCD3(1), PLCD4(1), PLCE1(2), PLCG1(1), PLCG2(1), PLCZ1(2), PPP3CA(1), PPP3CC(1), PRKACA(1), PRKCA(2), PRKCG(1), PRKX(2), RYR1(8), RYR2(10), RYR3(5), SLC8A1(1), SLC8A3(3), SPHK2(1), TACR1(1), TACR3(1), TBXA2R(2), TRHR(1), VDAC1(1) 105372452 182 113 181 79 71 21 10 43 37 0 0.837 1.000 1.000 536 HSA04810_REGULATION_OF_ACTIN_CYTOSKELETON Genes involved in regulation of actin cytoskeleton ABI2, ACTN1, ACTN2, ACTN3, ACTN4, APC, APC2, ARAF, ARHGEF1, ARHGEF12, ARHGEF4, ARHGEF6, ARHGEF7, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, ARPC5, ARPC5L, BAIAP2, BCAR1, BDKRB1, BDKRB2, BRAF, C3orf10, CD14, CDC42, CFL1, CFL2, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, CRK, CRKL, CSK, CYFIP1, CYFIP2, DIAPH1, DIAPH2, DIAPH3, DOCK1, EGF, EGFR, EZR, F2, F2R, FGD1, FGD3, FGF1, FGF10, FGF11, FGF12, FGF13, FGF14, FGF16, FGF17, FGF18, FGF19, FGF2, FGF20, FGF21, FGF22, FGF23, FGF3, FGF4, FGF5, FGF6, FGF7, FGF8, FGF9, FGFR1, FGFR2, FGFR3, FGFR4, FN1, GIT1, GNA12, GNA13, GNG12, GRLF1, GSN, HRAS, INS, IQGAP1, IQGAP2, IQGAP3, ITGA1, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAD, ITGAE, ITGAL, ITGAM, ITGAV, ITGAX, ITGB1, ITGB2, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, KRAS, LIMK1, LIMK2, LOC200025, LOC645126, LOC653888, MAP2K1, MAP2K2, MAPK1, MAPK3, MLCK, MOS, MRAS, MRCL3, MRLC2, MSN, MYH10, MYH14, MYH9, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLK, MYLK2, MYLPF, NCKAP1, NCKAP1L, NRAS, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PDGFA, PDGFB, PDGFRA, PDGFRB, PFN1, PFN2, PFN3, PFN4, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIP4K2A, PIP4K2B, PIP4K2C, PIP5K1A, PIP5K1B, PIP5K1C, PIP5K3, PPP1CA, PPP1CB, PPP1CC, PPP1R12A, PPP1R12B, PTK2, PXN, RAC1, RAC2, RAC3, RAF1, RDX, RHOA, ROCK1, ROCK2, RRAS, RRAS2, SCIN, SLC9A1, SOS1, SOS2, SSH1, SSH2, SSH3, TIAM1, TIAM2, TMSB4X, TMSB4Y, TMSL3, VAV1, VAV2, VAV3, VCL, WAS, WASF1, WASF2, WASL 202 APC(2), ARAF(1), ARHGEF1(3), ARHGEF6(1), ARPC5(1), ARPC5L(1), BCAR1(1), BDKRB1(1), CFL1(1), CHRM4(1), CRK(1), CYFIP1(2), CYFIP2(4), DIAPH1(1), DIAPH3(2), EGFR(2), F2(1), FGD1(1), FGD3(1), FGF10(1), FGF16(1), FGF23(2), FGF5(2), FGF9(3), FGFR2(2), FGFR3(1), FN1(2), GNA13(1), GSN(1), HRAS(3), IQGAP1(3), IQGAP2(1), ITGA10(1), ITGA11(2), ITGA2(1), ITGA2B(3), ITGA3(2), ITGA6(2), ITGA7(1), ITGA9(2), ITGAD(1), ITGAL(3), ITGAM(2), ITGAV(2), ITGB2(2), ITGB4(2), ITGB5(1), ITGB6(2), ITGB8(1), LIMK1(1), LIMK2(3), MAPK1(1), MRAS(1), MSN(1), MYH10(4), MYH9(1), MYL5(1), MYLK(3), MYLK2(2), NCKAP1L(2), PAK2(1), PDGFRA(2), PDGFRB(1), PFN1(1), PFN2(2), PIK3CA(10), PIK3CB(1), PIK3CG(3), PIK3R1(1), PIK3R2(2), PIK3R3(1), PIP5K1C(2), PPP1CA(1), PTK2(2), PXN(1), RAC1(1), RAC2(1), RAF1(1), ROCK1(5), RRAS2(1), SLC9A1(1), SOS1(1), SSH1(2), SSH2(5), SSH3(1), TIAM1(2), TIAM2(2), VAV1(3), VAV2(1), VAV3(1), WASF2(1) 107585393 161 112 160 34 49 15 17 60 20 0 0.00979 1.000 1.000 537 HSA01430_CELL_COMMUNICATION Genes involved in cell communication ACTB, ACTG1, CHAD, COL11A1, COL11A2, COL17A1, COL1A1, COL1A2, COL2A1, COL3A1, COL4A1, COL4A2, COL4A4, COL4A6, COL5A1, COL5A2, COL5A3, COL6A1, COL6A2, COL6A3, COL6A6, COMP, DES, DSC1, DSC2, DSC3, DSG1, DSG2, DSG3, DSG4, FN1, GJA1, GJA10, GJA3, GJA4, GJA5, GJA8, GJA9, GJB1, GJB2, GJB3, GJB4, GJB5, GJB6, GJB7, GJC1, GJC2, GJC3, GJD2, GJD3, GJD4, IBSP, INA, ITGA6, ITGB4, KRT1, KRT10, KRT12, KRT13, KRT14, KRT15, KRT16, KRT17, KRT18, KRT19, KRT2, KRT20, KRT23, KRT24, KRT25, KRT27, KRT28, KRT3, KRT31, KRT32, KRT33A, KRT33B, KRT34, KRT35, KRT36, KRT37, KRT38, KRT39, KRT4, KRT40, KRT5, KRT6A, KRT6B, KRT6C, KRT7, KRT71, KRT72, KRT73, KRT74, KRT75, KRT76, KRT77, KRT78, KRT79, KRT8, KRT81, KRT82, KRT83, KRT84, KRT85, KRT86, KRT9, LAMA1, LAMA2, LAMA3, LAMA4, LAMA5, LAMB1, LAMB2, LAMB3, LAMB4, LAMC1, LAMC2, LAMC3, LMNA, LMNB1, LMNB2, LOC728760, NES, PRPH, RELN, SPP1, THBS1, THBS2, THBS3, THBS4, TNC, TNN, TNR, TNXB, VIM, VTN, VWF 136 ACTG1(1), COL11A1(7), COL11A2(4), COL17A1(1), COL1A1(3), COL1A2(1), COL3A1(2), COL4A1(1), COL4A2(2), COL4A4(1), COL5A1(3), COL5A3(2), COL6A1(2), COL6A3(5), COL6A6(2), COMP(1), DSC3(1), DSG1(1), DSG2(3), FN1(2), GJA1(1), GJA4(1), GJA5(2), GJA8(3), GJB4(1), GJB5(1), GJC2(1), ITGA6(2), ITGB4(2), KRT1(1), KRT14(1), KRT15(2), KRT16(1), KRT18(1), KRT23(2), KRT24(1), KRT25(4), KRT31(2), KRT33A(1), KRT38(2), KRT39(1), KRT4(1), KRT5(1), KRT6A(1), KRT6C(3), KRT7(1), KRT73(1), KRT75(1), KRT77(1), KRT78(3), KRT79(1), KRT83(1), KRT84(1), KRT85(1), LAMA1(3), LAMA2(3), LAMA3(4), LAMA4(4), LAMA5(1), LAMB1(4), LAMB2(2), LAMB3(1), LAMB4(1), LAMC1(3), LAMC2(1), LAMC3(1), LMNA(2), NES(2), RELN(3), THBS1(2), THBS4(1), TNC(2), TNN(2), TNXB(7), VWF(4) 97388752 148 95 148 45 67 21 7 34 19 0 0.0595 1.000 1.000 538 HSA04010_MAPK_SIGNALING_PATHWAY Genes involved in MAPK signaling pathway ACVR1B, ACVR1C, AKT1, AKT2, AKT3, ARRB1, ARRB2, ATF2, ATF4, BDNF, BRAF, CACNA1A, CACNA1B, CACNA1C, CACNA1D, CACNA1E, CACNA1F, CACNA1G, CACNA1H, CACNA1I, CACNA1S, CACNA2D1, CACNA2D2, CACNA2D3, CACNA2D4, CACNB1, CACNB2, CACNB3, CACNB4, CACNG1, CACNG2, CACNG3, CACNG4, CACNG5, CACNG6, CACNG7, CACNG8, CASP3, CD14, CDC25B, CDC42, CHP, CHUK, CRK, CRKL, DAXX, DDIT3, DUSP1, DUSP10, DUSP14, DUSP16, DUSP2, DUSP3, DUSP4, DUSP5, DUSP6, DUSP7, DUSP8, DUSP9, ECSIT, EGF, EGFR, ELK1, ELK4, EVI1, FAS, FASLG, FGF1, FGF10, FGF11, FGF12, FGF13, FGF14, FGF16, FGF17, FGF18, FGF19, FGF2, FGF20, FGF21, FGF22, FGF23, FGF3, FGF4, FGF5, FGF6, FGF7, FGF8, FGF9, FGFR1, FGFR2, FGFR3, FGFR4, FLNA, FLNB, FLNC, FOS, GADD45A, GADD45B, GADD45G, GNA12, GNG12, GRB2, HRAS, IKBKB, IKBKG, IL1A, IL1B, IL1R1, IL1R2, JUN, JUND, KRAS, LOC653852, MAP2K1, MAP2K1IP1, MAP2K2, MAP2K3, MAP2K4, MAP2K5, MAP2K6, MAP2K7, MAP3K1, MAP3K10, MAP3K12, MAP3K13, MAP3K14, MAP3K2, MAP3K3, MAP3K4, MAP3K5, MAP3K6, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAP3K8, MAP4K1, MAP4K2, MAP4K3, MAP4K4, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK7, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MAPKAPK2, MAPKAPK3, MAPKAPK5, MAPT, MAX, MEF2C, MKNK1, MKNK2, MOS, MRAS, MYC, NF1, NFATC2, NFATC4, NFKB1, NFKB2, NGFB, NLK, NR4A1, NRAS, NTF3, NTF5, NTRK1, NTRK2, PAK1, PAK2, PDGFA, PDGFB, PDGFRA, PDGFRB, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PPM1A, PPM1B, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PPP5C, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, PTPN5, PTPN7, PTPRR, RAC1, RAC2, RAC3, RAF1, RAP1A, RAP1B, RAPGEF2, RASA1, RASA2, RASGRF1, RASGRF2, RASGRP1, RASGRP2, RASGRP3, RASGRP4, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA4, RPS6KA5, RPS6KA6, RRAS, RRAS2, SOS1, SOS2, SRF, STK3, STK4, STMN1, TAOK1, TAOK2, TAOK3, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TNF, TNFRSF1A, TP53, TRAF2, TRAF6, ZAK 245 ACVR1B(1), AKT1(1), AKT2(1), ATF2(1), ATF4(1), CACNA1A(8), CACNA1C(1), CACNA1D(2), CACNA1E(7), CACNA1F(1), CACNA1G(1), CACNA1H(2), CACNA1I(1), CACNA1S(2), CACNA2D1(1), CACNA2D3(1), CACNA2D4(1), CACNB1(2), CACNB2(2), CACNB4(2), CACNG3(1), CACNG4(1), CACNG7(2), CACNG8(1), CDC25B(2), CRK(1), DAXX(1), DUSP1(1), DUSP16(1), DUSP7(1), DUSP8(2), ECSIT(2), EGFR(2), FAS(1), FASLG(1), FGF10(1), FGF16(1), FGF23(2), FGF5(2), FGF9(3), FGFR2(2), FGFR3(1), FLNC(1), GRB2(1), HRAS(3), JUND(1), MAP2K4(1), MAP2K7(2), MAP3K10(4), MAP3K12(1), MAP3K13(1), MAP3K5(1), MAP3K7(2), MAP4K1(1), MAPK1(1), MAPK8IP3(2), MAPKAPK3(1), MAPKAPK5(1), MEF2C(2), MRAS(1), NF1(1), NFATC2(1), NLK(1), NTRK1(3), PAK2(1), PDGFRA(2), PDGFRB(1), PLA2G12B(1), PLA2G2A(1), PLA2G4A(2), PLA2G6(1), PPP3CA(1), PPP3CC(1), PPP5C(1), PRKACA(1), PRKCA(2), PRKCG(1), PRKX(2), PTPN5(1), RAC1(1), RAC2(1), RAF1(1), RAPGEF2(1), RASGRF1(2), RASGRF2(1), RPS6KA1(1), RPS6KA4(2), RPS6KA5(3), RPS6KA6(1), RRAS2(1), SOS1(1), STK4(2), TAOK1(1), TAOK2(3), TGFB1(1), TGFB2(1), TGFBR1(2), TNF(1), TRAF2(3) 111111286 153 93 153 51 52 15 19 38 29 0 0.452 1.000 1.000 539 CALCIUM_REGULATION_IN_CARDIAC_CELLS ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADRA1A, ADRA1B, ADRA1D, ADRB1, ADRB2, ADRB3, ANXA6, ARRB1, ARRB2, ATP1A4, ATP1B1, ATP1B2, ATP1B3, ATP2A2, ATP2A3, ATP2B1, ATP2B2, ATP2B3, CACNA1A, CACNA1B, CACNA1C, CACNA1D, CACNA1E, CACNA1S, CACNB1, CACNB3, CALM1, CALM2, CALM3, CALR, CAMK1, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CASQ1, CASQ2, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, FXYD2, GJA1, GJA12, GJA4, GJA5, GJB1, GJB2, GJB3, GJB4, GJB5, GJB6, GNA11, GNAI2, GNAI3, GNAO1, GNAQ, GNAZ, GNB1, GNB2, GNB3, GNB4, GNB5, GNG12, GNG13, GNG2, GNG3, GNG4, GNG5, GNG7, GNGT1, GRK4, GRK5, GRK6, ITPR1, ITPR2, ITPR3, KCNB1, KCNJ3, KCNJ5, MGC11266, MYCBP, NME7, PEA15, PKIA, PKIB, PKIG, PLCB3, PLN, PRKACA, PRKACB, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCQ, PRKCZ, PRKD1, RGS1, RGS10, RGS11, RGS14, RGS16, RGS17, RGS18, RGS19, RGS2, RGS20, RGS3, RGS4, RGS5, RGS6, RGS7, RGS9, RYR1, RYR2, RYR3, SARA1, SFN, SLC8A1, SLC8A3, USP5, YWHAB, YWHAH, YWHAQ, YWHAQ, MIB1 139 ADCY1(1), ADCY3(1), ADCY4(2), ADCY6(2), ADCY8(4), ADCY9(2), ADRA1A(1), ADRA1B(2), ADRA1D(2), ADRB1(1), ANXA6(1), ATP2A2(1), ATP2B1(1), ATP2B2(4), ATP2B3(2), CACNA1A(8), CACNA1C(1), CACNA1D(2), CACNA1E(7), CACNA1S(2), CACNB1(2), CAMK1(2), CAMK2A(1), CAMK2D(1), CAMK4(2), CHRM4(1), GJA1(1), GJA4(1), GJA5(2), GJB4(1), GJB5(1), GNAI2(1), GNAO1(1), GNAZ(1), GNB1(1), GNB3(1), GNB4(1), GNB5(1), GNGT1(1), GRK6(1), ITPR1(2), ITPR2(3), ITPR3(1), KCNB1(3), KCNJ5(1), MIB1(1), PRKACA(1), PRKAR1A(1), PRKAR1B(1), PRKCA(2), PRKCG(1), PRKCH(1), PRKCQ(1), PRKCZ(2), PRKD1(2), RGS11(1), RGS16(2), RGS6(1), RGS9(2), RYR1(8), RYR2(10), RYR3(5), SLC8A1(1), SLC8A3(3), YWHAH(1), YWHAQ(1) 73428182 129 87 129 54 55 10 7 32 25 0 0.847 1.000 1.000 540 HSA04512_ECM_RECEPTOR_INTERACTION Genes involved in ECM-receptor interaction AGRN, CD36, CD44, CD47, CHAD, COL11A1, COL11A2, COL1A1, COL1A2, COL2A1, COL3A1, COL4A1, COL4A2, COL4A4, COL4A6, COL5A1, COL5A2, COL5A3, COL6A1, COL6A2, COL6A3, COL6A6, DAG1, FN1, FNDC1, FNDC3A, FNDC4, FNDC5, GP1BA, GP1BB, GP5, GP6, GP9, HMMR, HSPG2, IBSP, ITGA1, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAV, ITGB1, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, LAMA1, LAMA2, LAMA3, LAMA4, LAMA5, LAMB1, LAMB2, LAMB3, LAMB4, LAMC1, LAMC2, LAMC3, RELN, SDC1, SDC2, SDC3, SDC4, SPP1, SV2A, SV2B, SV2C, THBS1, THBS2, THBS3, THBS4, TNC, TNN, TNR, TNXB, VTN, VWF 85 AGRN(1), COL11A1(7), COL11A2(4), COL1A1(3), COL1A2(1), COL3A1(2), COL4A1(1), COL4A2(2), COL4A4(1), COL5A1(3), COL5A3(2), COL6A1(2), COL6A3(5), COL6A6(2), DAG1(1), FN1(2), FNDC1(3), FNDC3A(1), GP5(3), GP9(1), HSPG2(7), ITGA10(1), ITGA11(2), ITGA2(1), ITGA2B(3), ITGA3(2), ITGA6(2), ITGA7(1), ITGA9(2), ITGAV(2), ITGB4(2), ITGB5(1), ITGB6(2), ITGB8(1), LAMA1(3), LAMA2(3), LAMA3(4), LAMA4(4), LAMA5(1), LAMB1(4), LAMB2(2), LAMB3(1), LAMB4(1), LAMC1(3), LAMC2(1), LAMC3(1), RELN(3), SDC3(1), SV2A(1), SV2B(1), THBS1(2), THBS4(1), TNC(2), TNN(2), TNXB(7), VWF(4) 87908901 128 84 128 41 51 17 5 35 20 0 0.177 1.000 1.000 541 HSA04360_AXON_GUIDANCE Genes involved in axon guidance ABL1, ABLIM1, ABLIM2, ABLIM3, ARHGEF12, CDC42, CDK5, CFL1, CFL2, CHP, CXCL12, CXCR4, DCC, DPYSL2, DPYSL5, EFNA1, EFNA2, EFNA3, EFNA4, EFNA5, EFNB1, EFNB2, EFNB3, EPHA1, EPHA2, EPHA3, EPHA4, EPHA5, EPHA6, EPHA7, EPHA8, EPHB1, EPHB2, EPHB3, EPHB4, EPHB6, FES, FYN, GNAI1, GNAI2, GNAI3, GSK3B, HRAS, ITGB1, KRAS, L1CAM, LIMK1, LIMK2, LRRC4C, MAPK1, MAPK3, MET, NCK1, NCK2, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NGEF, NRAS, NRP1, NTN1, NTN2L, NTN4, NTNG1, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PLXNA1, PLXNA2, PLXNA3, PLXNB1, PLXNB2, PLXNB3, PLXNC1, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PTK2, RAC1, RAC2, RAC3, RASA1, RGS3, RHOA, RHOD, RND1, ROBO1, ROBO2, ROBO3, ROCK1, ROCK2, SEMA3A, SEMA3B, SEMA3C, SEMA3D, SEMA3E, SEMA3F, SEMA3G, SEMA4A, SEMA4B, SEMA4C, SEMA4D, SEMA4F, SEMA4G, SEMA5A, SEMA5B, SEMA6A, SEMA6B, SEMA6C, SEMA6D, SEMA7A, SLIT1, SLIT2, SLIT3, SRGAP1, SRGAP2, SRGAP3, UNC5A, UNC5B, UNC5C, UNC5D 127 ABL1(4), ABLIM1(2), CFL1(1), DCC(2), DPYSL2(1), DPYSL5(1), EFNA5(1), EFNB3(1), EPHA1(1), EPHA2(1), EPHA3(4), EPHA4(1), EPHA5(1), EPHA6(1), EPHA7(2), EPHB1(3), EPHB2(3), EPHB3(2), FES(2), GNAI1(1), GNAI2(1), GSK3B(1), HRAS(3), L1CAM(3), LIMK1(1), LIMK2(3), LRRC4C(1), MAPK1(1), MET(1), NFATC1(1), NFATC2(1), NGEF(1), NRP1(1), NTN1(1), NTNG1(3), PAK2(1), PLXNA1(1), PLXNA2(1), PLXNB1(1), PLXNB2(1), PLXNC1(1), PPP3CA(1), PPP3CC(1), PTK2(2), RAC1(1), RAC2(1), RHOD(1), ROBO1(5), ROBO2(3), ROBO3(1), ROCK1(5), SEMA3A(1), SEMA3C(1), SEMA3D(3), SEMA3E(2), SEMA3F(1), SEMA3G(1), SEMA4A(1), SEMA4C(2), SEMA4F(1), SEMA5A(1), SEMA5B(1), SEMA6A(1), SEMA6C(1), SEMA6D(2), SLIT1(2), SLIT3(1), SRGAP1(4), UNC5A(1), UNC5B(4), UNC5D(1) 77195808 117 80 116 31 42 11 16 35 13 0 0.0741 1.000 1.000 542 HSA04310_WNT_SIGNALING_PATHWAY Genes involved in Wnt signaling pathway APC, APC2, AXIN1, AXIN2, BTRC, CACYBP, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CCND1, CCND2, CCND3, CER1, CHD8, CHP, CREBBP, CSNK1A1, CSNK1A1L, CSNK1E, CSNK2A1, CSNK2A2, CSNK2B, CTBP1, CTBP2, CTNNB1, CTNNBIP1, CUL1, CXXC4, DAAM1, DAAM2, DKK1, DKK2, DKK4, DVL1, DVL2, DVL3, EP300, FBXW11, FOSL1, FRAT1, FRAT2, FZD1, FZD10, FZD2, FZD3, FZD4, FZD5, FZD6, FZD7, FZD8, FZD9, GSK3B, JUN, LEF1, LOC652788, LRP5, LRP6, MAP3K7, MAPK10, MAPK8, MAPK9, MMP7, MYC, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NKD1, NKD2, NLK, PLCB1, PLCB2, PLCB3, PLCB4, PORCN, PPARD, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRICKLE1, PRICKLE2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, PSEN1, RAC1, RAC2, RAC3, RBX1, RHOA, ROCK1, ROCK2, RUVBL1, SENP2, SFRP1, SFRP2, SFRP4, SFRP5, SIAH1, SKP1, SMAD2, SMAD3, SMAD4, SOX17, TBL1X, TBL1XR1, TBL1Y, TCF7, TCF7L1, TCF7L2, TP53, VANGL1, VANGL2, WIF1, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT3A, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B, WNT8A, WNT8B, WNT9A, WNT9B 142 APC(2), AXIN2(2), CACYBP(1), CAMK2A(1), CAMK2D(1), CCND3(1), CHD8(1), CREBBP(4), CSNK1A1L(1), CSNK1E(1), CSNK2A2(1), CTBP2(1), DAAM2(2), DKK2(2), DVL2(2), EP300(4), FBXW11(1), FZD1(2), FZD10(2), FZD2(4), FZD4(2), FZD5(1), FZD6(1), FZD9(2), GSK3B(1), LEF1(1), LRP5(2), LRP6(1), MAP3K7(2), NFATC1(1), NFATC2(1), NKD2(1), NLK(1), PLCB1(2), PLCB4(3), PPARD(1), PPP2R1B(1), PPP2R2B(3), PPP2R2C(1), PPP3CA(1), PPP3CC(1), PRICKLE1(1), PRICKLE2(1), PRKACA(1), PRKCA(2), PRKCG(1), PRKX(2), RAC1(1), RAC2(1), ROCK1(5), SFRP2(1), SMAD2(1), SMAD3(1), SMAD4(4), SOX17(1), TBL1XR1(2), TCF7L1(1), TCF7L2(2), VANGL2(2), WIF1(2), WNT2(1), WNT5A(1), WNT6(2), WNT9A(1) 62561298 103 73 101 36 31 15 15 25 17 0 0.453 1.000 1.000 543 HSA04530_TIGHT_JUNCTION Genes involved in tight junction ACTB, ACTG1, ACTN1, ACTN2, ACTN3, ACTN4, AKT1, AKT2, AKT3, AMOTL1, ASH1L, CASK, CDC42, CDK4, CGN, CLDN1, CLDN10, CLDN11, CLDN14, CLDN15, CLDN16, CLDN17, CLDN18, CLDN19, CLDN2, CLDN20, CLDN22, CLDN23, CLDN3, CLDN4, CLDN5, CLDN6, CLDN7, CLDN8, CLDN9, CRB3, CSDA, CSNK2A1, CSNK2A2, CSNK2B, CTNNA1, CTNNA2, CTNNA3, CTNNB1, CTTN, EPB41, EPB41L1, EPB41L2, EPB41L3, EXOC3, EXOC4, F11R, GNAI1, GNAI2, GNAI3, HCLS1, HRAS, IGSF5, INADL, JAM2, JAM3, KRAS, LLGL1, LLGL2, MAGI1, MAGI2, MAGI3, MLLT4, MPDZ, MPP5, MRAS, MRCL3, MRLC2, MYH1, MYH10, MYH11, MYH13, MYH14, MYH15, MYH2, MYH3, MYH4, MYH6, MYH7, MYH7B, MYH8, MYH9, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLPF, NRAS, OCLN, PARD3, PARD6A, PARD6B, PARD6G, PPM1J, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, PPP2R3A, PPP2R3B, PPP2R4, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCI, PRKCQ, PRKCZ, PTEN, RAB13, RAB3B, RHOA, RRAS, RRAS2, SPTAN1, SRC, SYMPK, TJAP1, TJP1, TJP2, TJP3, VAPA, YES1, ZAK 129 ACTG1(1), AKT1(1), AKT2(1), ASH1L(3), CGN(2), CLDN15(1), CLDN23(1), CLDN9(2), CSNK2A2(1), CTNNA2(4), CTNNA3(1), CTTN(1), EPB41L1(1), EPB41L2(1), EPB41L3(8), GNAI1(1), GNAI2(1), HRAS(3), INADL(4), JAM2(1), LLGL2(1), MAGI3(1), MLLT4(1), MPDZ(2), MRAS(1), MYH1(2), MYH10(4), MYH13(5), MYH15(1), MYH2(1), MYH4(6), MYH6(4), MYH7(4), MYH7B(4), MYH8(1), MYH9(1), MYL5(1), PPP2R1B(1), PPP2R2B(3), PPP2R2C(1), PPP2R3A(1), PPP2R4(1), PRKCA(2), PRKCG(1), PRKCH(1), PRKCQ(1), PRKCZ(2), RRAS2(1), TJAP1(1), TJP1(1), TJP2(3), TJP3(2), VAPA(1) 74905278 102 73 102 24 40 11 6 30 15 0 0.0307 1.000 1.000 544 GPCRDB_CLASS_A_RHODOPSIN_LIKE ADORA1, ADORA2A, ADORA2B, ADORA3, ADRA1A, ADRA1B, ADRA1D, ADRA2A, ADRA2C, ADRB1, ADRB2, ADRB3, AGTR1, AGTR2, AGTRL1, AVPR1A, AVPR1B, AVPR2, BDKRB1, BDKRB2, BLR1, BRS3, C3AR1, C5R1, CCBP2, CCKAR, CCKBR, CCR1, CCR10, CCR2, CCR3, CCR4, CCR5, CCR6, CCR7, CCR8, CCR9, CCRL1, CCRL2, CHML, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, CMKLR1, CMKOR1, CNR1, CNR2, CX3CR1, CXCR3, CXCR4, DRD1, DRD2, DRD3, DRD4, DRD5, EDNRA, EDNRB, ELA3A, F2R, F2RL1, F2RL2, F2RL3, FPR1, FPRL1, FPRL2, FSHR, GALR1, GALR2, GALR3, GALT, GHSR, GNB2L1, GPR10, GPR147, GPR17, GPR173, GPR174, GPR23, GPR24, GPR27, GPR3, GPR30, GPR35, GPR37, GPR37L1, GPR4, GPR44, GPR50, GPR6, GPR63, GPR74, GPR77, GPR83, GPR85, GPR87, GPR92, GRPR, HCRTR1, HCRTR2, HRH1, HRH2, HRH3, HTR1A, HTR1B, HTR1D, HTR1E, HTR1F, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, HTR7, LOC93164, IL8RA, IL8RB, LHCGR, LTB4R, MAS1, MC1R, MC3R, MC4R, MC5R, MLNR, MTNR1A, MTNR1B, NMBR, NMUR1, NMUR2, NPY1R, NPY2R, NPY5R, NPY6R, NTSR1, NTSR2, OPN1SW, OPN3, OPRD1, OPRK1, OPRL1, OPRM1, OR10A5, OR11A1, OR12D3, OR1C1, OR1F1, OR1Q1, OR2H1, OR5V1, OR5V1, OR12D3, OR7A5, OR7C1, OR8B8, OXTR, P2RY1, P2RY10, P2RY11, P2RY12, P2RY13, P2RY14, P2RY2, P2RY5, P2RY6, PPYR1, PTAFR, PTGDR, PTGER1, PTGER2, PTGER4, PTGFR, PTGIR, Rgr, RGR, RHO, RRH, SSTR1, SSTR2, SSTR3, SSTR4, SUCNR1, TBXA2R, TRHR 163 ADORA1(2), ADORA2A(1), ADORA3(1), ADRA1A(1), ADRA1B(2), ADRA1D(2), ADRA2A(2), ADRA2C(1), ADRB1(1), AGTR1(2), AVPR1B(1), BDKRB1(1), BRS3(1), C3AR1(1), CCKAR(2), CCKBR(1), CCR2(1), CCR4(1), CCR6(1), CCR7(1), CCR9(1), CHRM4(1), CMKLR1(1), CNR1(2), DRD2(1), DRD3(1), FPR1(1), FSHR(1), GPR17(1), GPR174(1), GPR35(1), GPR37L1(2), GPR4(1), GPR50(2), GPR83(1), GPR87(2), HCRTR2(3), HTR1A(2), HTR1D(1), HTR1E(2), HTR2A(2), HTR2B(1), HTR2C(2), HTR4(1), HTR5A(1), HTR6(2), LHCGR(1), MAS1(1), MC3R(1), MTNR1A(1), MTNR1B(1), NMUR1(1), NMUR2(1), NPY1R(1), NPY2R(1), NTSR1(1), OR1Q1(1), OR7A5(2), P2RY1(1), P2RY10(1), P2RY14(1), P2RY6(1), PTGIR(1), RGR(1), SSTR1(1), SSTR2(1), SSTR3(1), TBXA2R(2), TRHR(1) 47523331 88 69 88 33 35 12 5 26 10 0 0.286 1.000 1.000 545 SMOOTH_MUSCLE_CONTRACTION ACTA1, ACTA2, ACTC, ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADM, ADMR, ARRB1, ARRB2, ATF1, ATF2, ATF3, ATF4, ATF5, ATP2A2, ATP2A3, CACNB3, CALCA, CALM1, CALM2, CALM3, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CMKOR1, CNN1, CNN2, CORIN, CREB3, CREBL1, CREBL1, TNXB, CRH, CRHR1, DGKZ, EDG2, ETS2, FOS, GABPA, GABPB2, GBA2, GJA1, GNAQ, GNB1, GNB2, GNB3, GNB4, GNB5, GNG12, GNG13, GNG2, GNG3, GNG4, GNG5, GNG7, GNGT1, GRK4, GRK5, GRK6, GSTO1, GUCA2A, GUCA2B, GUCY1A3, HEAB, IGFBP1, IGFBP2, IGFBP3, IGFBP4, IGFBP6, IL1B, IL6, ITPR1, ITPR2, ITPR3, JUN, LGR7, LGR8, MAFF, MGC11266, MYL2, MYL4, MYLK2, NFKB1, NOS1, NOS3, OXT, OXTR, PDE4B, PDE4D, PKIA, PKIB, PKIG, PLCB3, PLCD1, PLCG1, PLCG2, PRKACA, PRKACB, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCH, PRKCQ, PRKCZ, PRKD1, RAMP1, RAMP2, RAMP3, RCP9, RGS1, RGS10, RGS11, RGS14, RGS16, RGS17, RGS18, RGS19, RGS2, RGS20, RGS3, RGS4, RGS5, RGS6, RGS7, RGS9, RLN1, RYR1, RYR2, RYR3, SARA1, SFN, SLC8A1, SP1, USP5, YWHAB, YWHAH, YWHAQ, YWHAQ, MIB1 138 ADCY1(1), ADCY3(1), ADCY4(2), ADCY6(2), ADCY8(4), ADCY9(2), ATF2(1), ATF4(1), ATP2A2(1), CAMK2A(1), CAMK2D(1), CORIN(2), CREB3(1), DGKZ(1), GJA1(1), GNB1(1), GNB3(1), GNB4(1), GNB5(1), GNGT1(1), GRK6(1), GUCY1A3(1), IL6(1), ITPR1(2), ITPR2(3), ITPR3(1), MAFF(1), MIB1(1), MYLK2(2), NOS1(2), NOS3(1), PDE4D(1), PLCG1(1), PLCG2(1), PRKACA(1), PRKAR1A(1), PRKAR1B(1), PRKCA(2), PRKCH(1), PRKCQ(1), PRKCZ(2), PRKD1(2), RAMP2(1), RGS11(1), RGS16(2), RGS6(1), RGS9(2), RYR1(8), RYR2(10), RYR3(5), SLC8A1(1), SP1(1), TNXB(7), YWHAH(1), YWHAQ(1) 67860714 98 66 98 53 38 10 7 23 20 0 0.992 1.000 1.000 546 HSA04540_GAP_JUNCTION Genes involved in gap junction ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADRB1, CDC2, CSNK1D, DRD1, DRD2, EDG2, EGF, EGFR, GJA1, GJD2, GNA11, GNAI1, GNAI2, GNAI3, GNAQ, GNAS, GRB2, GRM1, GRM5, GUCY1A2, GUCY1A3, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, HRAS, HTR2A, HTR2B, HTR2C, ITPR1, ITPR2, ITPR3, KRAS, LOC643224, LOC654264, MAP2K1, MAP2K2, MAP2K5, MAP3K2, MAPK1, MAPK3, MAPK7, NPR1, NPR2, NRAS, PDGFA, PDGFB, PDGFC, PDGFD, PDGFRA, PDGFRB, PLCB1, PLCB2, PLCB3, PLCB4, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKG1, PRKG2, PRKX, PRKY, RAF1, SOS1, SOS2, SRC, TJP1, TUBA1A, TUBA1B, TUBA1C, TUBA3C, TUBA3D, TUBA3E, TUBA4A, TUBA8, TUBAL3, TUBB, TUBB1, TUBB2A, TUBB2B, TUBB2C, TUBB3, TUBB4, TUBB4Q, TUBB6, TUBB8 92 ADCY1(1), ADCY3(1), ADCY4(2), ADCY6(2), ADCY8(4), ADCY9(2), ADRB1(1), DRD2(1), EGFR(2), GJA1(1), GNAI1(1), GNAI2(1), GNAS(2), GRB2(1), GRM1(2), GRM5(3), GUCY1A2(2), GUCY1A3(1), GUCY2C(2), GUCY2F(3), HRAS(3), HTR2A(2), HTR2B(1), HTR2C(2), ITPR1(2), ITPR2(3), ITPR3(1), MAPK1(1), PDGFRA(2), PDGFRB(1), PLCB1(2), PLCB4(3), PRKACA(1), PRKCA(2), PRKCG(1), PRKG1(1), PRKX(2), RAF1(1), SOS1(1), TJP1(1), TUBA1A(1), TUBA3C(3), TUBA3E(1), TUBA4A(1), TUBB1(1), TUBB2B(1), TUBB3(1), TUBB6(1), TUBB8(1) 51649626 79 61 78 26 29 10 5 21 14 0 0.361 1.000 1.000 547 HSA00230_PURINE_METABOLISM Genes involved in purine metabolism ADA, ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADK, ADSL, ADSS, ADSSL1, AK1, AK2, AK3L1, AK5, AK7, ALLC, AMPD1, AMPD2, AMPD3, APRT, ATIC, CANT1, DCK, DGUOK, ECGF1, ENPP1, ENPP3, ENTPD1, ENTPD2, ENTPD3, ENTPD4, ENTPD5, ENTPD6, ENTPD8, FHIT, GART, GDA, GMPR, GMPR2, GMPS, GUCY1A2, GUCY1A3, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, GUK1, HPRT1, IMPDH1, IMPDH2, ITPA, NME1, NME2, NME4, NME6, NME7, NP, NPR1, NPR2, NT5C, NT5C1A, NT5C1B, NT5C2, NT5C3, NT5E, NT5M, NUDT2, NUDT5, NUDT9, PAICS, PAPSS1, PAPSS2, PDE10A, PDE11A, PDE1A, PDE1C, PDE2A, PDE3B, PDE4A, PDE4B, PDE4C, PDE4D, PDE5A, PDE6D, PDE6G, PDE6H, PDE7A, PDE7B, PDE8A, PDE8B, PDE9A, PFAS, PKLR, PKM2, PNPT1, POLA1, POLA2, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, POLE3, POLE4, POLR1A, POLR1B, POLR1C, POLR1D, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLR3A, POLR3B, POLR3G, POLR3GL, POLR3H, POLR3K, PPAT, PRIM1, PRIM2, PRPS1, PRPS1L1, PRPS2, PRUNE, RFC5, RRM1, RRM2, RRM2B, SAC, XDH, ZNRD1 142 ADA(1), ADCY1(1), ADCY3(1), ADCY4(2), ADCY6(2), ADCY8(4), ADCY9(2), AK5(1), AK7(1), AMPD1(1), AMPD2(2), AMPD3(1), ATIC(2), CANT1(2), DGUOK(1), ENPP1(2), ENPP3(1), ENTPD6(2), FHIT(1), GART(1), GMPR(1), GMPR2(1), GUCY1A2(2), GUCY1A3(1), GUCY2C(2), GUCY2F(3), NT5C1B(1), NT5C2(2), NT5M(1), PAPSS2(1), PDE10A(1), PDE1C(1), PDE2A(1), PDE3B(1), PDE4A(2), PDE4C(1), PDE4D(1), PDE7A(1), PDE8A(2), PDE8B(1), POLA1(1), POLD1(1), POLD3(1), POLE(2), POLR1B(1), POLR1C(1), POLR2A(2), POLR3A(2), POLR3B(1), PRPS1L1(2) 63787391 72 59 71 31 24 12 10 15 11 0 0.764 1.000 1.000 548 HSA04916_MELANOGENESIS Genes involved in melanogenesis ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ASIP, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CREB1, CREB3, CREB3L1, CREB3L2, CREB3L3, CREB3L4, CREBBP, CTNNB1, DCT, DVL1, DVL2, DVL3, EDN1, EDNRB, EP300, FZD1, FZD10, FZD2, FZD3, FZD4, FZD5, FZD6, FZD7, FZD8, FZD9, GNAI1, GNAI2, GNAI3, GNAO1, GNAQ, GNAS, GSK3B, HRAS, KIT, KITLG, KRAS, LEF1, LOC652788, MAP2K1, MAP2K2, MAPK1, MAPK3, MC1R, MITF, NRAS, PLCB1, PLCB2, PLCB3, PLCB4, POMC, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, RAF1, TCF7, TCF7L1, TCF7L2, TYR, TYRP1, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT3A, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B, WNT8A, WNT8B, WNT9A, WNT9B 98 ADCY1(1), ADCY3(1), ADCY4(2), ADCY6(2), ADCY8(4), ADCY9(2), CALML6(1), CAMK2A(1), CAMK2D(1), CREB3(1), CREB3L2(1), CREB3L3(1), CREBBP(4), DVL2(2), EP300(4), FZD1(2), FZD10(2), FZD2(4), FZD4(2), FZD5(1), FZD6(1), FZD9(2), GNAI1(1), GNAI2(1), GNAO1(1), GNAS(2), GSK3B(1), HRAS(3), LEF1(1), MAPK1(1), PLCB1(2), PLCB4(3), POMC(1), PRKACA(1), PRKCA(2), PRKCG(1), PRKX(2), RAF1(1), TCF7L1(1), TCF7L2(2), WNT2(1), WNT5A(1), WNT6(2), WNT9A(1) 42102211 74 55 74 38 25 15 8 15 11 0 0.873 1.000 1.000 549 HSA04650_NATURAL_KILLER_CELL_MEDIATED_CYTOTOXICITY Genes involved in natural killer cell mediated cytotoxicity ARAF, BID, BRAF, CASP3, CD244, CD247, CD48, CHP, CSF2, FAS, FASLG, FCER1G, FCGR3A, FCGR3B, FYN, GRB2, GZMB, HCST, HLA-A, HLA-B, HLA-C, HLA-E, HLA-G, HRAS, ICAM1, ICAM2, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IFNG, IFNGR1, IFNGR2, ITGAL, ITGB2, KIR2DL1, KIR2DL2, KIR2DL3, KIR2DL4, KIR2DL5A, KIR2DS1, KIR2DS2, KIR3DL1, KIR3DL2, KLRC1, KLRC2, KLRC3, KLRD1, KLRK1, KRAS, LAT, LCK, LCP2, LOC652578, MAP2K1, MAP2K2, MAPK1, MAPK3, MICA, MICB, NCR1, NCR2, NCR3, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NRAS, PAK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PLCG2, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRF1, PRKCA, PRKCB1, PRKCG, PTK2B, PTPN11, PTPN6, RAC1, RAC2, RAC3, RAF1, SH2D1A, SH2D1B, SH3BP2, SHC1, SHC2, SHC3, SHC4, SOS1, SOS2, SYK, TNF, TNFRSF10A, TNFRSF10B, TNFRSF10C, TNFRSF10D, TNFSF10, TYROBP, ULBP1, ULBP2, ULBP3, VAV1, VAV2, VAV3, ZAP70 125 ARAF(1), CD48(2), FAS(1), FASLG(1), GRB2(1), HLA-G(1), HRAS(3), IFNA10(1), IFNA13(1), IFNA16(1), ITGAL(3), ITGB2(2), KIR2DL1(1), KIR3DL1(2), MAPK1(1), MICB(1), NCR2(1), NFATC1(1), NFATC2(1), PIK3CA(10), PIK3CB(1), PIK3CG(3), PIK3R1(1), PIK3R2(2), PIK3R3(1), PLCG1(1), PLCG2(1), PPP3CA(1), PPP3CC(1), PRF1(1), PRKCA(2), PRKCG(1), RAC1(1), RAC2(1), RAF1(1), SHC1(2), SHC2(1), SOS1(1), SYK(2), TNF(1), TNFRSF10A(1), TNFRSF10B(1), VAV1(3), VAV2(1), VAV3(1), ZAP70(2) 43730551 71 52 71 23 27 7 11 20 6 0 0.339 1.000 1.000 550 G_PROTEIN_SIGNALING ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, AKAP1, AKAP10, AKAP11, AKAP12, AKAP2, PALM2_AKAP2, AKAP3, AKAP4, AKAP5, AKAP6, AKAP7, AKAP8, AKAP9, ARHGEF1, CALM1, CALM2, CALM3, CHMP1B, GNA11, GNA12, GNA13, GNA14, GNA15, GNAI2, GNAI3, GNAL, GNAO1, GNAQ, GNAZ, GNB1, GNB2, GNB3, GNB5, GNG10, GNG10, LOC552891, GNG12, GNG13, GNG3, GNG4, GNG5, GNG7, GNGT1, GNGT2, HRAS, IL18BP, ITPR1, KCNJ3, KRAS, MGC11266, NRAS, PALM2, PALM2_AKAP2, PALM2_AKAP2, PDE1A, PDE1B, PDE1C, PDE4A, PDE4B, PDE4C, PDE4D, PDE7A, PDE7B, PDE8A, PDE8B, PLCB3, PPP3CA, PPP3CC, PRKACA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCI, PRKCQ, PRKCZ, PRKD1, PRKD3, RHOA, RRAS, SARA1, SLC9A1, USP5 92 ADCY1(1), ADCY3(1), ADCY4(2), ADCY6(2), ADCY8(4), ADCY9(2), AKAP1(1), AKAP11(1), AKAP12(5), AKAP3(1), AKAP4(1), AKAP6(1), AKAP8(1), AKAP9(5), ARHGEF1(3), GNA13(1), GNAI2(1), GNAL(1), GNAO1(1), GNAZ(1), GNB1(1), GNB3(1), GNB5(1), GNGT1(1), HRAS(3), ITPR1(2), PDE1B(1), PDE1C(1), PDE4A(2), PDE4C(1), PDE4D(1), PDE7A(1), PDE8A(2), PDE8B(1), PPP3CA(1), PPP3CC(1), PRKACA(1), PRKAR1A(1), PRKAR1B(1), PRKCA(2), PRKCG(1), PRKCH(1), PRKCQ(1), PRKCZ(2), PRKD1(2), PRKD3(1), SLC9A1(1) 45694199 71 50 71 28 23 7 7 22 12 0 0.711 1.000 1.000 551 HSA04912_GNRH_SIGNALING_PATHWAY Genes involved in GnRH signaling pathway ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ATF4, CACNA1C, CACNA1D, CACNA1F, CACNA1S, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CDC42, CGA, EGFR, ELK1, FSHB, GNA11, GNAQ, GNAS, GNRH1, GNRH2, GNRHR, GRB2, HBEGF, HRAS, ITPR1, ITPR2, ITPR3, JUN, KRAS, LHB, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAP3K1, MAP3K2, MAP3K3, MAP3K4, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK7, MAPK8, MAPK9, MMP14, MMP2, NRAS, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCB1, PLCB2, PLCB3, PLCB4, PLD1, PLD2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCD, PRKX, PRKY, PTK2B, RAF1, SOS1, SOS2, SRC 95 ADCY1(1), ADCY3(1), ADCY4(2), ADCY6(2), ADCY8(4), ADCY9(2), ATF4(1), CACNA1C(1), CACNA1D(2), CACNA1F(1), CACNA1S(2), CALML6(1), CAMK2A(1), CAMK2D(1), EGFR(2), GNAS(2), GNRHR(3), GRB2(1), HRAS(3), ITPR1(2), ITPR2(3), ITPR3(1), MAP2K4(1), MAP2K7(2), MAPK1(1), MMP14(1), PLA2G12B(1), PLA2G2A(1), PLA2G4A(2), PLA2G6(1), PLCB1(2), PLCB4(3), PLD1(2), PRKACA(1), PRKCA(2), PRKX(2), RAF1(1), SOS1(1) 49650415 63 50 63 25 19 12 4 15 13 0 0.734 1.000 1.000 552 PURINE_METABOLISM 1_Sep, ADA, ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADK, ADSL, ADSS, AK1, AK2, AK5, ALLC, AMPD1, AMPD2, AMPD3, APRT, ATIC, ATP1B1, ATP5A1, ATP5B, ATP5C1, ATP5D, ATP5F1, ATP5G1, ATP5G2, ATP5G3, ATP5H, ATP5I, ATP5J, ATP5J2, CANT1, DCK, DGUOK, ECGF1, ENPP1, ENPP3, ENTPD1, ENTPD2, FHIT, GART, GDA, GMPS, GUCY1A2, GUCY1A3, GUCY1B2, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, GUK1, HPRT1, IMPDH1, IMPDH2, ITPA, NME1, NME2, NP, NPR1, NPR2, NT5C, NT5E, NT5M, NUDT2, PAICS, PAPSS1, PAPSS2, PDE1A, PDE4A, PDE4B, PDE4C, PDE4D, PDE5A, PDE6B, PDE6C, PDE6G, PDE7B, PDE8A, PDE9A, PFAS, PKLR, PKM2, POLA, POLB, POLD1, POLD2, POLE, POLG, POLL, POLQ, POLR1B, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLRMT, POLS, PPAT, PRPS1, PRPS1L1, PRPS2, PRUNE, RRM1, RRM2, SAC 110 ADA(1), ADCY1(1), ADCY3(1), ADCY4(2), ADCY6(2), ADCY8(4), AK5(1), AMPD1(1), AMPD2(2), AMPD3(1), ATIC(2), ATP5A1(2), CANT1(2), DGUOK(1), ENPP1(2), ENPP3(1), FHIT(1), GART(1), GUCY1A2(2), GUCY1A3(1), GUCY2C(2), GUCY2F(3), NT5M(1), PAPSS2(1), PDE4A(2), PDE4C(1), PDE4D(1), PDE6B(1), PDE6C(1), PDE8A(2), POLD1(1), POLE(2), POLG(1), POLL(1), POLQ(3), POLR1B(1), POLR2A(2), PRPS1L1(2) 50126451 59 48 58 28 18 8 11 14 8 0 0.897 1.000 1.000 553 HSA02010_ABC_TRANSPORTERS_GENERAL Genes involved in ABC transporters - general ABCA1, ABCA10, ABCA12, ABCA13, ABCA2, ABCA3, ABCA4, ABCA5, ABCA6, ABCA7, ABCA8, ABCA9, ABCB1, ABCB10, ABCB11, ABCB4, ABCB5, ABCB6, ABCB7, ABCB8, ABCB9, ABCC1, ABCC10, ABCC11, ABCC12, ABCC2, ABCC3, ABCC4, ABCC5, ABCC6, ABCC8, ABCC9, ABCD1, ABCD2, ABCD3, ABCD4, ABCG1, ABCG2, ABCG4, ABCG5, ABCG8, CFTR, TAP1, TAP2 44 ABCA1(1), ABCA12(4), ABCA13(5), ABCA3(1), ABCA4(3), ABCA5(5), ABCA9(1), ABCB1(4), ABCB5(2), ABCB6(1), ABCB7(1), ABCC10(1), ABCC11(3), ABCC12(2), ABCC3(2), ABCC4(3), ABCC5(3), ABCC6(1), ABCC8(1), ABCC9(2), ABCD3(1), ABCG1(1), ABCG2(1), CFTR(1), TAP1(1), TAP2(1) 45999186 52 42 52 29 13 10 8 12 9 0 0.938 1.000 1.000 554 HSA04610_COMPLEMENT_AND_COAGULATION_CASCADES Genes involved in complement and coagulation cascades A2M, BDKRB1, BDKRB2, C1QA, C1QB, C1QC, C1R, C1S, C2, C3, C3AR1, C4A, C4B, C4BPA, C4BPB, C5, C5AR1, C6, C7, C8A, C8B, C8G, C9, CD46, CD55, CD59, CFB, CFD, CFH, CFI, CPB2, CR1, CR2, F10, F11, F12, F13A1, F13B, F2, F2R, F3, F5, F7, F8, F9, FGA, FGB, FGG, KLKB1, KNG1, MASP1, MASP2, MBL2, PLAT, PLAU, PLAUR, PLG, PROC, PROS1, SERPINA1, SERPINA5, SERPINC1, SERPIND1, SERPINE1, SERPINF2, SERPING1, TFPI, THBD, VWF 67 A2M(2), BDKRB1(1), C1S(1), C3(1), C3AR1(1), C6(2), C8B(1), C9(1), CD46(2), CFB(2), CFH(6), CFI(1), CPB2(1), F10(1), F11(2), F12(1), F13A1(1), F13B(1), F2(1), F3(1), F5(3), F7(2), FGA(3), KLKB1(1), MASP1(2), MASP2(1), PLAT(2), PLAU(2), PLG(1), PROS1(2), SERPIND1(2), VWF(4) 35268195 55 42 55 22 17 5 6 18 9 0 0.765 1.000 1.000 555 HSA01030_GLYCAN_STRUCTURES_BIOSYNTHESIS_1 Genes involved in glycan structures - biosynthesis 1 A4GNT, ALG1, ALG10, ALG10B, ALG11, ALG12, ALG13, ALG14, ALG2, ALG3, ALG6, ALG8, ALG9, B3GALT6, B3GNT1, B3GNT2, B3GNT6, B3GNT7, B4GALT1, B4GALT2, B4GALT3, B4GALT4, B4GALT5, B4GALT7, C1GALT1, C1GALT1C1, ChGn, CHPF, CHST1, CHST11, CHST12, CHST13, CHST14, CHST2, CHST3, CHST4, CHST6, CHST7, CHSY-2, CHSY1, CSGlcA-T, DAD1, DDOST, DPAGT1, EXT1, EXT2, EXTL1, EXTL2, EXTL3, FUT11, FUT8, GALNAC4S-6ST, GALNACT-2, GALNT1, GALNT10, GALNT11, GALNT12, GALNT13, GALNT14, GALNT17, GALNT2, GALNT3, GALNT4, GALNT5, GALNT6, GALNT7, GALNT8, GALNT9, GALNTL1, GALNTL2, GALNTL4, GALNTL5, GANAB, GCNT1, GCNT3, GCNT4, GCS1, HS2ST1, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, HS3ST5, HS6ST1, HS6ST2, HS6ST3, LOC728969, MAN1A1, MAN1A2, MAN1B1, MAN1C1, MAN2A1, MGAT1, MGAT2, MGAT3, MGAT4A, MGAT4B, MGAT5, MGAT5B, NDST1, NDST2, NDST3, NDST4, OGT, RPN1, RPN2, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4, ST6GAL1, ST6GALNAC1, STT3B, UST, WBSCR17, XYLT1, XYLT2 108 A4GNT(1), ALG12(1), ALG14(2), B3GNT7(1), B4GALT1(2), B4GALT2(1), CHPF(1), CHST11(1), CHST4(1), CHSY1(1), EXT1(1), EXT2(2), EXTL1(2), EXTL3(2), GALNT10(2), GALNT11(1), GALNT13(1), GALNT3(2), GALNT8(1), GALNTL5(3), GANAB(1), HS6ST1(1), MAN1A1(2), MAN1C1(1), MAN2A1(1), MGAT5(1), MGAT5B(2), NDST1(2), NDST2(2), NDST4(3), OGT(1), RPN1(1), ST3GAL1(2), ST6GAL1(1), UST(1), WBSCR17(1), XYLT1(4), XYLT2(1) 43048449 57 41 57 15 22 8 6 13 8 0 0.163 1.000 1.000 556 MAPKPATHWAY The mitogen-activated protein (MAP) kinase pathway is a common signaling mechanism and has four main sub-pathways: Erk, JNK/SAPK, p53, and ERK5. ARAF1, ATF2, BRAF, CEBPA, CHUK, CREB1, DAXX, ELK1, FOS, GRB2, HRAS, IKBKB, JUN, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K5, MAP2K6, MAP2K7, MAP3K1, MAP3K10, MAP3K11, MAP3K12, MAP3K13, MAP3K14, MAP3K2, MAP3K3, MAP3K4, MAP3K5, MAP3K6, MAP3K7, MAP3K8, MAP3K9, MAP4K1, MAP4K2, MAP4K3, MAP4K4, MAP4K5, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK4, MAPK6, MAPK7, MAPK8, MAPK9, MAPKAPK2, MAPKAPK3, MAPKAPK5, MAX, MEF2A, MEF2B, MEF2C, MEF2D, MKNK1, MKNK2, MYC, NFKB1, NFKBIA, PAK1, PAK2, PDZGEF1, RAC1, RAF1, RELA, RIPK1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA4, RPS6KA5, RPS6KB1, RPS6KB2, SHC1, SP1, STAT1, TGFB1, TGFB2, TGFB3, TGFBR1, TRADD, TRAF2 83 ATF2(1), DAXX(1), GRB2(1), HRAS(3), MAP2K4(1), MAP2K7(2), MAP3K10(4), MAP3K11(2), MAP3K12(1), MAP3K13(1), MAP3K5(1), MAP3K7(2), MAP3K9(1), MAP4K1(1), MAPK1(1), MAPKAPK3(1), MAPKAPK5(1), MEF2A(1), MEF2C(2), MEF2D(1), PAK2(1), RAC1(1), RAF1(1), RELA(2), RIPK1(1), RPS6KA1(1), RPS6KA4(2), RPS6KA5(3), RPS6KB2(1), SHC1(2), SP1(1), STAT1(1), TGFB1(1), TGFB2(1), TGFBR1(2), TRAF2(3) 36767646 53 40 53 17 19 4 10 11 9 0 0.460 1.000 1.000 557 GPCRDB_OTHER ADORA3, ALG6, C5R1, CCKBR, CCR2, CCR3, CCR5, CELSR1, CELSR2, CELSR3, CHRM2, CHRM3, CIDEB, CXCR3, DRD4, EBI2, EDG1, EDNRA, ELA3A, EMR2, EMR3, F2R, FSHR, FY, GHRHR, GNRHR, GPR, GPR116, GPR132, GPR133, GPR135, GPR143, GPR145, GPR17, GPR18, GPR55, GPR56, GPR61, GPR73L1, GPR77, GPR84, GPR88, GRCA, GRM1, GRPR, HRH4, IL8RA, IL8RB, LGR6, LGR7, LPHN2, LPHN3, LTB4R2, MASS1, NTSR1, OR2A9P, OR2M4, OR5E1P, OR7E19P, OR7E47P, OR7E37P, OR7E18P, OR7E35P, LOC441453, OR8G1, LOC442754, OR8G2, P2RY11, P2RY13, PTGFR, RLN3R1, SMO, SSTR2, TAAR5, TSHR, VN1R1 53 ADORA3(1), CCKBR(1), CCR2(1), CELSR1(2), CELSR2(4), CELSR3(2), EMR2(4), FSHR(1), GNRHR(3), GPR132(1), GPR133(2), GPR17(1), GPR18(1), GPR55(1), GRM1(2), LPHN2(3), LPHN3(6), NTSR1(1), OR2M4(1), SSTR2(1), TAAR5(1), TSHR(1), VN1R1(2) 26082924 43 37 41 19 16 4 5 13 5 0 0.606 1.000 1.000 558 HSA04742_TASTE_TRANSDUCTION Genes involved in taste transduction ACCN1, ADCY4, ADCY6, ADCY8, CACNA1A, CACNA1B, GNAS, GNAT3, GNB1, GNB3, GNG13, GNG3, GRM4, ITPR3, KCNB1, PDE1A, PLCB2, PRKACA, PRKACB, PRKACG, PRKX, PRKY, SCNN1A, SCNN1B, SCNN1G, TAS1R1, TAS1R2, TAS1R3, TAS2R1, TAS2R10, TAS2R13, TAS2R14, TAS2R16, TAS2R3, TAS2R38, TAS2R39, TAS2R4, TAS2R40, TAS2R41, TAS2R42, TAS2R43, TAS2R44, TAS2R45, TAS2R46, TAS2R48, TAS2R49, TAS2R5, TAS2R50, TAS2R60, TAS2R7, TAS2R8, TAS2R9, TRPM5 48 ADCY4(2), ADCY6(2), ADCY8(4), CACNA1A(8), GNAS(2), GNB1(1), GNB3(1), GRM4(1), ITPR3(1), KCNB1(3), PRKACA(1), PRKX(2), SCNN1B(3), SCNN1G(1), TAS1R2(1), TAS2R16(1), TAS2R38(2), TAS2R4(1), TAS2R42(1), TAS2R46(1), TAS2R5(1), TRPM5(1) 22337556 41 34 41 19 17 3 3 11 7 0 0.844 1.000 1.000 559 HSA04640_HEMATOPOIETIC_CELL_LINEAGE Genes involved in hematopoietic cell lineage ANPEP, CD14, CD19, CD1A, CD1B, CD1C, CD1D, CD1E, CD2, CD22, CD24, CD33, CD34, CD36, CD37, CD38, CD3D, CD3E, CD3G, CD4, CD44, CD5, CD55, CD59, CD7, CD8A, CD8B, CD9, CR1, CR2, CSF1, CSF1R, CSF2, CSF2RA, CSF3, CSF3R, DNTT, EPO, EPOR, FCER2, FCGR1A, FLT3, FLT3LG, GP1BA, GP1BB, GP5, GP9, GYPA, HLA-DRA, HLA-DRB1, HLA-DRB3, HLA-DRB4, HLA-DRB5, IL11, IL11RA, IL1A, IL1B, IL1R1, IL1R2, IL2RA, IL3, IL3RA, IL4, IL4R, IL5, IL5RA, IL6, IL6R, IL7, IL7R, IL9R, ITGA1, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGAM, ITGB3, KIT, KITLG, MME, MS4A1, TFRC, THPO, TNF, TPO 83 CD1B(1), CD1C(1), CD1E(1), CD38(1), CD8A(1), CD8B(1), CSF1R(2), CSF2RA(2), CSF3R(1), FCGR1A(1), FLT3(1), GP5(3), GP9(1), HLA-DRA(1), IL11RA(1), IL3RA(1), IL4(1), IL4R(2), IL6(1), IL7(1), IL7R(1), ITGA2(1), ITGA2B(3), ITGA3(2), ITGA6(2), ITGAM(2), MME(2), TNF(1), TPO(1) 31837614 40 33 40 17 9 6 3 14 8 0 0.728 1.000 1.000 560 MRNA_PROCESSING_REACTOME BRUNOL4, C10orf9, C20orf14, CD2BP2, CDC40, CLK2, CLK3, CLK4, COL2A1, CPSF1, CPSF2, CPSF3, CPSF4, CSTF1, CSTF2, CSTF2T, CSTF3, CUGBP1, CUGBP2, DDIT3, DDX1, DDX20, DHX15, DHX16, DHX38, DHX8, DHX9, DICER1, DNAJC8, FLJ10748, FNBP3, FUS, FUSIP1, GIPC1, HEAB, HNRPA2B1, HNRPA3, HNRPA3P1, HNRPA3, LOC387933, HNRPA3P1, HNRPA3, LOC389395, HNRPAB, HNRPC, HNRPC, HNRPCL1, LOC390615, LOC440563, HNRPD, HNRPH1, HNRPH2, HNRPL, HNRPR, HNRPU, HRMT1L2, LSM2, LSM7, METTL3, NCBP1, NCBP2, NONO, NUDT21, NXF1, PABPN1, PAPOLA, PHF5A, POLR2A, PPM1G, PRPF18, PRPF3, PRPF4, PRPF4B, PRPF8, PSKH1, PTBP1, PTBP2, RBM17, RBM5, RNGTT, RNMT, RNPC2, RNPS1, SF3A1, SF3A2, SF3A3, SF3B1, SF3B2, SF3B4, SF3B5, SF4, SFRS10, SFRS12, SFRS14, SFRS16, SFRS2, SFRS4, SFRS5, SFRS6, SFRS7, SFRS8, SFRS9, SMC1L1, SNRP70, SNRPA, SNRPA1, SNRPB, SNRPB2, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF, SNRPG, SNRPN, SNRPN, PAR1, SNRPN, SNURF, SPOP, SRPK1, SRPK2, SRRM1, SUPT5H, TMP21, TXNL4A, U2AF1, U2AF2, WDR57, XRN2 91 CDC40(1), CLK3(2), CPSF2(1), CSTF2T(1), CSTF3(1), DHX15(1), DHX16(1), DHX38(1), DHX8(1), DHX9(1), DICER1(1), METTL3(2), NONO(1), PHF5A(1), POLR2A(2), PPM1G(2), PRPF3(2), PRPF4(1), PRPF4B(1), PRPF8(2), PTBP1(2), RBM17(1), RBM5(2), SF3A1(2), SF3A2(1), SF3A3(1), SF3B1(1), SF3B5(1), SNRPD2(1), SNRPD3(1), SNRPN(1), SUPT5H(1) 40940459 41 33 41 12 10 6 10 7 8 0 0.437 1.000 1.000 561 HSA04340_HEDGEHOG_SIGNALING_PATHWAY Genes involved in Hedgehog signaling pathway BMP2, BMP4, BMP5, BMP6, BMP7, BMP8A, BMP8B, BTRC, CSNK1A1, CSNK1A1L, CSNK1D, CSNK1E, CSNK1G1, CSNK1G2, CSNK1G3, DHH, FBXW11, GAS1, GLI1, GLI2, GLI3, GSK3B, HHIP, IHH, LRP2, PRKACA, PRKACB, PRKACG, PRKX, PRKY, PTCH1, PTCH2, RAB23, SHH, SMO, STK36, SUFU, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT3A, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B, WNT8A, WNT8B, WNT9A, WNT9B, ZIC2 56 BMP5(2), BMP6(1), BMP7(3), BMP8B(1), CSNK1A1L(1), CSNK1E(1), CSNK1G1(1), CSNK1G3(1), FBXW11(1), GLI1(3), GLI2(3), GLI3(1), GSK3B(1), HHIP(3), LRP2(2), PRKACA(1), PRKX(2), PTCH1(1), PTCH2(4), SHH(2), STK36(1), SUFU(1), WNT2(1), WNT5A(1), WNT6(2), WNT9A(1) 23860463 42 31 42 19 17 7 5 9 4 0 0.631 1.000 1.000 562 G1_TO_S_CELL_CYCLE_REACTOME ATM, CCNA1, CCNB1, CCND1, CCND2, CCND3, CCNE1, CCNE2, CCNG2, CCNH, CDC25A, CDC45L, CDK2, CDK4, CDK7, CDKN1A, CDKN1B, CDKN1C, CDKN2A, CDKN2B, CDKN2C, CDKN2D, CREB3, CREB3L1, CREB3L3, CREB3L4, CREBL1, CREBL1, TNXB, E2F1, E2F2, E2F3, E2F4, E2F5, E2F6, FLJ14001, GADD45A, GBA2, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, MDM2, MNAT1, MYC, MYT1, NACA, NACA, FKSG17, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, POLA2, POLE, POLE2, PRIM1, PRIM2A, RB1, RBL1, RPA1, RPA2, RPA3, TFDP1, TFDP2, TP53, WEE1 62 CCNA1(1), CCND3(1), CCNE2(1), CCNG2(1), CDC25A(1), CDKN1A(2), CDKN1B(4), CDKN2A(1), CREB3(1), CREB3L3(1), E2F3(1), MCM3(1), MCM4(2), MCM5(1), MCM6(2), MCM7(1), MDM2(1), MYT1(1), NACA(1), POLE(2), RB1(2), RPA1(1), RPA2(1), TFDP1(1), TFDP2(1), TNXB(7) 27417486 40 29 40 18 13 4 5 7 10 1 0.861 1.000 1.000 563 WNT_SIGNALING Wnt signaling genes APC, ARHA, AXIN1, C2orf31, CCND1, CCND2, CCND3, CSNK1E, CSNK1E, LOC400927, CTNNB1, DIPA, DVL1, DVL2, DVL3, FBXW2, FOSL1, FRAT1, FZD1, FZD10, FZD2, FZD3, FZD5, FZD6, FZD7, FZD8, FZD9, GSK3B, JUN, LDLR, MAPK10, MAPK9, MYC, PAFAH1B1, PLAU, PPP2R5C, PPP2R5E, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCI, PRKCM, PRKCQ, PRKCZ, PRKD1, RAC1, RHOA, SFRP4, TCF7, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B 57 APC(2), CCND3(1), CSNK1E(1), DVL2(2), FZD1(2), FZD10(2), FZD2(4), FZD5(1), FZD6(1), FZD9(2), GSK3B(1), LDLR(1), PLAU(2), PPP2R5E(1), PRKCA(2), PRKCG(1), PRKCH(1), PRKCQ(1), PRKCZ(2), PRKD1(2), RAC1(1), WNT2(1), WNT5A(1), WNT6(2) 22950506 37 29 37 15 13 3 6 9 6 0 0.629 1.000 1.000 564 HSA04150_MTOR_SIGNALING_PATHWAY Genes involved in mTOR signaling pathway AKT1, AKT2, AKT3, BRAF, CAB39, DDIT4, EIF4B, EIF4EBP1, FIGF, FRAP1, GBL, HIF1A, IGF1, INS, KIAA1303, LYK5, MAPK1, MAPK3, PDPK1, PGF, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PRKAA1, PRKAA2, RHEB, RICTOR, RPS6, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA6, RPS6KB1, RPS6KB2, STK11, TSC1, TSC2, ULK1, ULK2, ULK3, VEGFA, VEGFB, VEGFC 43 AKT1(1), AKT2(1), DDIT4(1), MAPK1(1), PDPK1(1), PIK3CA(10), PIK3CB(1), PIK3CG(3), PIK3R1(1), PIK3R2(2), PIK3R3(1), PRKAA2(3), RPS6KA1(1), RPS6KA6(1), RPS6KB2(1), TSC2(2), ULK3(1), VEGFA(2) 20243988 34 28 34 12 11 7 4 8 4 0 0.533 1.000 1.000 565 HSA00790_FOLATE_BIOSYNTHESIS Genes involved in folate biosynthesis ALPI, ALPL, ALPP, ALPPL2, ASCC3, ASCC3L1, ATP13A2, DDX18, DDX19A, DDX23, DDX4, DDX41, DDX47, DDX50, DDX51, DDX52, DDX54, DDX55, DDX56, DHFR, DHX58, ENTPD7, EP400, ERCC2, ERCC3, FPGS, GCH1, GGH, IFIH1, MOV10L1, NUDT5, NUDT8, PTS, QDPR, RAD54B, RAD54L, RUVBL2, SETX, SKIV2L2, SMARCA2, SMARCA5, SPR 41 ALPI(1), ALPP(1), ALPPL2(1), ASCC3(1), ATP13A2(1), DDX23(1), DDX47(3), DDX50(3), DDX56(1), DHFR(1), ENTPD7(1), EP400(1), ERCC2(2), ERCC3(1), RAD54L(1), RUVBL2(2), SETX(2), SKIV2L2(3), SMARCA2(1), SMARCA5(3) 24540655 31 27 31 12 8 7 4 7 5 0 0.610 1.000 1.000 566 PEPTIDE_GPCRS AGTR1, AGTR2, ATP8A1, AVPR1A, AVPR1B, AVPR2, BDKRB1, BDKRB2, BLR1, BRS3, C3AR1, C5R1, CCKAR, CCKBR, CCR1, CCR10, CCR2, CCR3, CCR4, CCR5, CCR6, CCR7, CCR8, CX3CR1, CXCR3, CXCR4, CXCR6, EDNRA, EDNRB, ELA3A, FPR1, FPRL1, FPRL2, FSHR, FY, GALR1, GALR2, GALR3, GALT, GHSR, GNB2L1, GNRHR, GPR77, GRPR, IL8RA, IL8RB, LHCGR, MC1R, MC2R, MC3R, MC4R, MC5R, NMBR, NPY1R, NPY2R, NPY5R, NPY6R, NTSR1, NTSR2, OPRD1, OPRK1, OPRL1, OPRM1, OXTR, PPYR1, SSTR1, SSTR2, SSTR3, SSTR4, TAC4, TACR1, TACR2, TACR3, TRHR, TSHR 66 AGTR1(2), AVPR1B(1), BDKRB1(1), BRS3(1), C3AR1(1), CCKAR(2), CCKBR(1), CCR2(1), CCR4(1), CCR6(1), CCR7(1), CXCR6(1), FPR1(1), FSHR(1), GNRHR(3), LHCGR(1), MC3R(1), NPY1R(1), NPY2R(1), NTSR1(1), SSTR1(1), SSTR2(1), SSTR3(1), TACR1(1), TACR3(1), TRHR(1), TSHR(1) 20412369 31 27 31 13 10 2 2 12 5 0 0.687 1.000 1.000 567 RIBOSOMAL_PROTEINS ANK2, APG10L, RPS23, B3GALT4, CDR1, DGKI, FAU, IL6ST, KIAA1394, LOC133957, MRPL19, NET_5, PIGK, RPL10, RPL11, RPL12, RPL13, RPL13, LOC388344, RPL13A, RPL13A, LOC283340, LOC387930, RPL14, RPL14, RPL14L, RPL15, RPL15, LOC136321, LOC402694, RPL17, RPL17, dJ612B15.1, RPL18, RPL18A, LOC285053, LOC347544, LOC390354, RPL18A, LOC390354, RPL19, RPL21, RPL21, LOC387753, LOC388143, LOC388532, LOC388621, LOC389156, LOC390488, LOC402336, LOC440487, LOC440575, RPL21, LOC387753, LOC388143, LOC388532, LOC388621, LOC389156, LOC390488, LOC440487, LOC440575, RPL22, RPL23, RPL24, RPL24, SLC36A2, RPL26, LOC391126, LOC392501, LOC400055, LOC441073, LOC441533, RPL27, RPL27A, RPL27A, LOC389435, RPL28, RPL29, RPL29, LOC283412, LOC284064, LOC389655, LOC391738, LOC401911, RPL3, RPL30, RPL31, RPL32, RPL34, LOC342994, RPL35, RPL35A, RPL36, RPL37, RPL38, RPL39, RPL3L, RPL4, RPL41, RPL5, RPL5, LOC388907, RPL5, RNU66, LOC388907, RPL6, RPL7, RPL7, LOC389305, RPL7, LOC90193, LOC388401, LOC389305, LOC392550, LOC439954, RPL7A, RPL7A, LOC133748, LOC388474, RPL7A, RNU36B, LOC133748, LOC388474, RPL8, RPL9, RPLP0, RPLP0, RPLP0_like, RPLP1, RPLP2, RPS10, RPS10, LOC158104, LOC388885, LOC389127, LOC390842, LOC401817, RPS10, LOC388885, RPS11, RPS12, RPS13, RPS14, RPS15, RPS16, RPS16, LOC441876, RPS17, RPS17, LOC402057, RPS18, RPS19, RPS2, RPS2, LOC91561, LOC148430, LOC286444, LOC400963, LOC440589, RPS20, RPS21, RPS23, RPS24, RPS25, RPS26, RPS26L, LOC440440, RPS27, RPS27A, RPS27A, LOC388720, LOC389425, RPS28, RPS29, RPS3, RPS3A, RPS3A, LOC146053, LOC400652, LOC401016, LOC439992, RPS4X, RPS4Y1, RPS5, RPS6, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA6, RPS6KB1, RPS6KB2, RPS7, RPS8, RPS9, RPSA, LOC388524, LOC388654, SCDR10, TBC1D10C, TSPAN9, UBA52, UBB, UBC 93 ANK2(4), CDR1(1), DGKI(2), IL6ST(2), RPL11(2), RPL19(2), RPL28(1), RPL3(1), RPL37(1), RPL5(1), RPL8(1), RPS11(2), RPS27A(2), RPS6KA1(1), RPS6KA6(1), RPS6KB2(1), RPS9(1), SLC36A2(1), UBB(1), UBC(1) 20483815 29 27 29 14 7 4 2 8 8 0 0.971 1.000 1.000 568 HSA00380_TRYPTOPHAN_METABOLISM Genes involved in tryptophan metabolism AADAT, AANAT, ABP1, ACAT1, ACAT2, ACMSD, AFMID, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, AOC2, AOC3, AOX1, ASMT, CARM1, CAT, CYP1A1, CYP1A2, CYP1B1, DDC, ECHS1, EHHADH, GCDH, HAAO, HADH, HADHA, HEMK1, HSD17B10, HSD17B4, INDO, INDOL1, INMT, KMO, KYNU, LCMT1, LCMT2, LNX1, MAOA, MAOB, METTL2B, METTL6, NFX1, OGDH, OGDHL, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, TDO2, TPH1, TPH2, WARS, WARS2, WBSCR22 58 AADAT(1), ACAT1(1), ALDH1A3(1), ALDH3A1(1), AOC2(1), AOX1(1), ASMT(1), CAT(2), CYP1A1(1), CYP1A2(1), EHHADH(2), HADH(1), HSD17B4(1), KMO(1), KYNU(2), LNX1(1), METTL6(1), PRMT3(1), PRMT5(2), PRMT8(1), TDO2(1), TPH1(1), TPH2(1), WARS(1) 23617551 28 26 28 17 2 4 4 11 7 0 0.982 1.000 1.000 569 HSA04320_DORSO_VENTRAL_AXIS_FORMATION Genes involved in dorso-ventral axis formation BRAF, CPEB1, EGFR, ERBB2, ERBB4, ETS1, ETS2, ETV6, ETV7, FMN2, GRB2, KRAS, MAP2K1, MAPK1, MAPK3, NOTCH1, NOTCH2, NOTCH3, NOTCH4, PIWIL1, PIWIL2, PIWIL3, PIWIL4, RAF1, SOS1, SOS2, SPIRE1, SPIRE2 27 CPEB1(1), EGFR(2), ERBB2(1), ERBB4(1), FMN2(2), GRB2(1), MAPK1(1), NOTCH1(2), NOTCH2(4), NOTCH3(3), NOTCH4(2), PIWIL1(3), PIWIL2(1), PIWIL3(2), RAF1(1), SOS1(1) 19959520 28 26 28 12 9 5 3 5 6 0 0.750 1.000 1.000 570 IL2RBPATHWAY The beta subunit of the IL-2 receptor is required for IL-2 and IL-15 signal recognition and activates JAK kinase on ligand binding. AKT1, BAD, BCL2, BCL2L1, CBL, CFLAR, CRKL, E2F1, FOS, GRB2, HRAS, IL2RA, IL2RB, IL2RG, IRS1, JAK1, JAK3, MAPK1, MAPK3, MYC, NMI, PIK3CA, PIK3R1, PPIA, PTPN6, RAF1, RPS6KB1, SHC1, SOCS1, SOCS3, SOS1, STAT5A, STAT5B, SYK, TNFRSF6, TNFSF6, ZNFN1A3 34 AKT1(1), GRB2(1), HRAS(3), IRS1(2), JAK1(3), MAPK1(1), PIK3CA(10), PIK3R1(1), RAF1(1), SHC1(2), SOS1(1), STAT5B(1), SYK(2) 14123518 29 26 29 11 11 6 4 6 2 0 0.569 1.000 1.000 571 NO1PATHWAY Shear stress in endothelial cells increases cytoplasmic calcium, which activates nitric oxide synthase III to release NO, which in turn regulates cardiac contractions. ACTA1, AKT1, BDK, BDKRB2, CALM1, CALM2, CALM3, CAV1, CHRM1, CHRNA1, FLT1, FLT4, HSPCA, KDR, NOS3, PDE2A, PDE3A, PDE3B, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKG1, PRKG2, RYR2, SLC7A1, SYT1, TNNI1, VEGF 28 AKT1(1), FLT1(2), FLT4(2), KDR(3), NOS3(1), PDE2A(1), PDE3B(1), PRKAR1A(1), PRKAR1B(1), PRKG1(1), RYR2(10), SYT1(1) 15870708 25 24 25 14 11 3 0 6 5 0 0.912 1.000 1.000 572 BIOPEPTIDESPATHWAY Extracellular signaling peptides exert biological effects via G-protein coupled receptors (GPCRs), which activate intracellular GTPases. AGT, AGTR2, BDK, CALM1, CALM2, CALM3, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CDK5, F2, FYN, GNA11, GNAI1, GNB1, GNGT1, GRB2, HRAS, JAK2, MAP2K1, MAP2K2, MAPK1, MAPK14, MAPK3, MAPK8, MAPT, MYLK, PLCG1, PRKCA, PRKCB1, PTK2B, RAF1, SHC1, SOS1, STAT1, STAT3, STAT5A, SYT1 37 CAMK2A(1), CAMK2D(1), F2(1), GNAI1(1), GNB1(1), GNGT1(1), GRB2(1), HRAS(3), MAPK1(1), MYLK(3), PLCG1(1), PRKCA(2), RAF1(1), SHC1(2), SOS1(1), STAT1(1), STAT3(5), SYT1(1) 16253310 28 23 28 11 12 2 5 8 1 0 0.629 1.000 1.000 573 SIG_REGULATION_OF_THE_ACTIN_CYTOSKELETON_BY_RHO_GTPASES Genes related to regulation of the actin cytoskeleton ACTG1, ACTG2, ACTR2, ACTR3, AKT1, ANGPTL2, CDC42, CFL1, CFL2, FLNA, FLNC, FSCN1, FSCN2, FSCN3, GDI1, GDI2, LIMK1, MYH2, MYLK, MYLK2, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PFN1, PFN2, RHO, ROCK1, ROCK2, RPS4X, VASP, WASF1, WASL 35 ACTG1(1), ACTR3(1), AKT1(1), CFL1(1), FLNC(1), FSCN2(1), FSCN3(3), LIMK1(1), MYH2(1), MYLK(3), MYLK2(2), PAK2(1), PFN1(1), PFN2(2), ROCK1(5) 18680178 25 23 24 13 6 3 3 10 3 0 0.927 1.000 1.000 574 BLOOD_CLOTTING_CASCADE F10, F11, F12, F13B, F2, F5, F7, F8, F8A1, F9, FGA, FGB, FGG, LPA, PLG, PLAT, PLAU, PLG, SERPINB2, SERPINE1, SERPINF2, VWF 20 F10(1), F11(2), F12(1), F13B(1), F2(1), F5(3), F7(2), FGA(3), LPA(1), PLAT(2), PLAU(2), PLG(1), SERPINB2(1), VWF(4) 13735914 25 22 25 13 10 3 3 6 3 0 0.876 1.000 1.000 575 ARGININE_AND_PROLINE_METABOLISM ABP1, AGMAT, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH4A1, ALDH9A1, AMD1, AOC2, AOC3, ARG1, ARG2, ASL, ASS, CKB, CKM, CKMT1, CKMT1B, CKMT1A, CKMT2, CPS1, DAO, GAMT, GATM, GLUD1, GOT1, GOT2, MAOA, MAOB, NOS1, NOS2A, NOS3, OAT, ODC1, OTC, P4HA1, P4HA2, P4HA3, P4HB, PYCR1, RARS, SAT, SMS 43 ALDH1A1(1), ALDH1A2(3), ALDH1A3(1), ALDH3A1(1), ALDH4A1(1), AOC2(1), ARG2(1), CKB(1), CKMT2(2), DAO(1), GOT1(1), NOS1(2), NOS3(1), P4HA1(3), P4HA2(1), P4HA3(1) 17301100 22 21 21 16 5 2 3 10 2 0 0.995 1.000 1.000 576 KERATINOCYTEPATHWAY Keratinocyte differentiation, which models the differentiation of epidermal cells, requires the four main MAP kinase pathways. BCL2, CEBPA, CHUK, DAXX, EGF, EGFR, ETS1, ETS2, FOS, HOXA7, HRAS, IKBKB, JUN, MAP2K1, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAP3K1, MAP3K14, MAP3K5, MAPK1, MAPK13, MAPK14, MAPK3, MAPK8, NFKB1, NFKBIA, PPP2CA, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCQ, RAF1, RELA, RIPK1, SP1, TNF, TNFRSF1A, TNFRSF1B, TNFRSF6, TNFSF6, TRAF2 42 DAXX(1), EGFR(2), HRAS(3), MAP2K4(1), MAP2K7(2), MAP3K5(1), MAPK1(1), PRKCA(2), PRKCG(1), PRKCH(1), PRKCQ(1), RAF1(1), RELA(2), RIPK1(1), SP1(1), TNF(1), TRAF2(3) 19188879 25 21 25 12 8 3 5 7 2 0 0.822 1.000 1.000 577 DNA_REPLICATION_REACTOME ASK, CDC45L, CDC6, CDC7, CDK2, CDT1, DIAPH2, GMNN, MCM10, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, NACA, NACA, FKSG17, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, POLA, POLA2, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, PRIM1, PRIM2A, RFC1, RFC2, RFC3, RFC4, RFC5, RPA1, RPA2, RPA3, RPA4, RPS27A, RPS27A, LOC388720, LOC389425, UBA52, UBB, UBC 42 CDC6(1), CDC7(1), CDT1(1), MCM10(1), MCM3(1), MCM4(2), MCM5(1), MCM6(2), MCM7(1), NACA(1), POLD1(1), POLD3(1), POLE(2), RFC1(1), RFC3(1), RPA1(1), RPA2(1), RPA4(2), RPS27A(2), UBB(1), UBC(1) 19728642 26 20 26 14 8 5 3 5 5 0 0.873 1.000 1.000 578 HSA00310_LYSINE_DEGRADATION Genes involved in lysine degradation AADAT, AASDHPPT, AASS, ACAT1, ACAT2, AKR1B10, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, BBOX1, DLST, DOT1L, ECHS1, EHHADH, EHMT1, EHMT2, GCDH, HADH, HADHA, HSD17B10, HSD17B4, HSD3B7, NSD1, OGDH, OGDHL, PIPOX, PLOD1, PLOD2, PLOD3, RDH11, RDH12, RDH13, RDH14, SETD1A, SETD7, SETDB1, SHMT1, SHMT2, SPCS1, SPCS3, SUV39H1, SUV39H2, TMLHE 47 AADAT(1), ACAT1(1), ALDH1A3(1), ALDH3A1(1), BBOX1(1), DOT1L(3), EHHADH(2), EHMT2(1), HADH(1), HSD17B4(1), NSD1(1), PLOD1(1), PLOD3(1), RDH12(1), SETD1A(2), SETDB1(2), SHMT1(1), SHMT2(1) 22695148 23 20 23 10 6 5 3 5 4 0 0.726 1.000 1.000 579 HSA00970_AMINOACYL_TRNA_BIOSYNTHESIS Genes involved in aminoacyl-tRNA biosynthesis AARS, AARS2, CARS, CARS2, DARS, DARS2, EARS2, EPRS, FARS2, FARSA, FARSB, GARS, HARS, HARS2, IARS, IARS2, KARS, LARS, LARS2, MARS, MARS2, MTFMT, NARS, NARS2, PARS2, QARS, RARS, RARS2, SARS, SARS2, TARS, TARS2, VARS, VARS2, WARS, WARS2, YARS, YARS2 38 AARS(1), CARS(1), CARS2(2), DARS2(1), EPRS(2), FARSB(2), GARS(1), IARS(1), KARS(1), LARS(1), LARS2(2), MARS2(1), NARS2(1), PARS2(1), QARS(1), SARS(1), TARS(1), TARS2(1), VARS(2), VARS2(2), WARS(1), YARS2(1) 21149893 28 20 28 10 11 2 2 6 7 0 0.755 1.000 1.000 580 HSA00330_ARGININE_AND_PROLINE_METABOLISM Genes involved in arginine and proline metabolism ALDH4A1, ARG1, ARG2, ASL, ASS1, CKB, CKM, CKMT1A, CKMT1B, CKMT2, CPS1, DAO, EPRS, GAMT, GATM, GLUD1, GLUD2, GOT1, GOT2, LAP3, NOS1, NOS2A, NOS3, OAT, OTC, P4HA1, P4HA2, P4HA3, PARS2, PRODH, PYCR1, PYCR2, PYCRL, RARS, RARS2 34 ALDH4A1(1), ARG2(1), CKB(1), CKMT2(2), DAO(1), EPRS(2), GOT1(1), NOS1(2), NOS3(1), P4HA1(3), P4HA2(1), P4HA3(1), PARS2(1) 14075517 18 18 18 14 5 2 2 7 2 0 0.993 1.000 1.000 581 HSA00340_HISTIDINE_METABOLISM Genes involved in histidine metabolism ABP1, ACY3, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH7A1, ALDH9A1, AMDHD1, AOC2, AOC3, ASPA, CARM1, CNDP1, DDC, FTCD, HAL, HARS, HARS2, HDC, HEMK1, HNMT, LCMT1, LCMT2, MAOA, MAOB, METTL2B, METTL6, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, PRPS1, PRPS2, UROC1, WBSCR22 41 ACY3(1), ALDH1A3(1), ALDH3A1(1), ALDH3B1(1), AMDHD1(1), AOC2(1), CNDP1(2), HAL(1), METTL6(1), PRMT3(1), PRMT5(2), PRMT8(1), UROC1(3) 15452102 17 17 17 11 4 2 3 5 3 0 0.962 1.000 1.000 582 AMIPATHWAY Endogenous anti-thrombosis pathways are overwhelmed in plaque-narrowed blood vessels, resulting in potentially lethal myocardial infarction. ADCY1, CD3D, CD3E, CD3G, CD3Z, CD4, CREBBP, CSK, GNAS, GNB1, GNGT1, HLA-DRA, HLA-DRB1, LCK, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTPRC, TRA@, TRB@, ZAP70 21 ADCY1(1), CREBBP(4), GNAS(2), GNB1(1), GNGT1(1), HLA-DRA(1), PRKAR1A(1), PRKAR1B(1), PTPRC(3), ZAP70(2) 8978040 17 16 17 11 5 1 1 9 1 0 0.973 1.000 1.000 583 CSKPATHWAY Csk inhibits T-cell activation by phosphorylating Lck; Csk is regulated by cAMP-dependent kinases and is opposed by the T-cell activator CD45. ADCY1, CD3D, CD3E, CD3G, CD3Z, CD4, CREBBP, CSK, GNAS, GNB1, GNGT1, HLA-DRA, HLA-DRB1, LCK, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTPRC, TRA@, TRB@, ZAP70 21 ADCY1(1), CREBBP(4), GNAS(2), GNB1(1), GNGT1(1), HLA-DRA(1), PRKAR1A(1), PRKAR1B(1), PTPRC(3), ZAP70(2) 8978040 17 16 17 11 5 1 1 9 1 0 0.973 1.000 1.000 584 HSA00251_GLUTAMATE_METABOLISM Genes involved in glutamate metabolism ABAT, ADC, ALDH4A1, ALDH5A1, CAD, CPS1, EARS2, EPRS, GAD1, GAD2, GCLC, GCLM, GFPT1, GFPT2, GLS, GLS2, GLUD1, GLUD2, GLUL, GMPS, GNPNAT1, GOT1, GOT2, GPT, GPT2, GSR, GSS, NADSYN1, NAGK, PPAT, QARS 31 ALDH4A1(1), ALDH5A1(1), CAD(1), EPRS(2), GAD2(4), GFPT2(2), GNPNAT1(1), GOT1(1), NADSYN1(1), NAGK(1), QARS(1) 15437491 16 15 16 13 6 1 1 4 4 0 0.993 1.000 1.000 585 GLUTAMATE_METABOLISM ABAT, ALDH4A1, ALDH5A1, CAD, CPS1, EPRS, GAD1, GAD2, GCLC, GCLM, GFPT1, GLS, GLS2, GLUD1, GLUL, GMPS, GOT1, GOT2, GPT, GPT2, GSS, NADSYN1, PPAT, QARS 24 ALDH4A1(1), ALDH5A1(1), CAD(1), EPRS(2), GAD2(4), GOT1(1), NADSYN1(1), QARS(1) 12963407 12 12 12 12 5 1 1 3 2 0 0.996 1.000 1.000 586 CHREBPPATHWAY Carbohydrate responsive element binding protein (chREBP) is a transcription factor inhibited by cAMP and activated by high carbohydrate levels. ADCY1, BG1, BUCS1, GNAS, GNB1, GNGT1, PPP2CA, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKACB, PRKACG, PRKAG1, PRKAG2, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, WBSCR14 17 ADCY1(1), GNAS(2), GNB1(1), GNGT1(1), PRKAA2(3), PRKAG1(2), PRKAR1A(1), PRKAR1B(1) 5991763 12 11 12 6 2 0 1 9 0 0 0.927 1.000 1.000 587 PLCEPATHWAY Gs-coupled receptors activate adenylyl cyclase, which activates Epac1, leading to the stimulation of PLC and subsequent DAG and IP3 production. ADCY1, ADRB2, GNAS, PLCE1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTGER1, RAP2B 11 ADCY1(1), GNAS(2), PLCE1(2), PRKAR1A(1), PRKAR1B(1), RAP2B(1) 5761782 8 8 8 7 1 0 0 7 0 0 0.994 1.000 1.000 588 AGPCRPATHWAY G-protein coupled receptors (GPCRs) transduce extracellular signals across the plasma membrane; attenuation occurs by signal molecule degradation or receptor-mediated endocytosis. ARRB1, GNAS, GNB1, GNGT1, GPRK2L, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1 11 GNAS(2), GNB1(1), GNGT1(1), PRKAR1A(1), PRKAR1B(1), PRKCA(2) 3752928 8 7 8 5 1 0 0 7 0 0 0.963 1.000 1.000 589 DNA_POLYMERASE POLA, POLB, POLD1, POLD2, POLE, POLG, POLL, POLQ, POLS 7 POLD1(1), POLE(2), POLG(1), POLL(1), POLQ(3) 6532244 8 7 8 5 3 1 2 2 0 0 0.880 1.000 1.000 590 GSPATHWAY Activated G-protein coupled receptors stimulate cAMP production and thus activate protein kinase A, involved in a number of signal transduction pathways. ADCY1, GNAS, GNB1, GNGT1, PRKACA, PRKAR1A 6 ADCY1(1), GNAS(2), GNB1(1), GNGT1(1), PRKACA(1), PRKAR1A(1) 2574393 7 7 7 5 0 0 0 7 0 0 0.990 1.000 1.000 591 RNA_TRANSCRIPTION_REACTOME CCNH, CDK7, ERCC3, GTF2A2, GTF2B, GTF2E1, GTF2E2, GTF2F2, GTF2H1, GTF2H2, GTF2H4, ILK, MGC9850, MNAT1, POLR1A, POLR1B, POLR2A, POLR2B, POLR2C, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR3B, POLR3D, POLR3E, POLR3H, POLR3K, TAF12, TAF13, TAF5, TAF6, TAF7, TAF9, TBP, VARS2L 36 ERCC3(1), GTF2E2(1), POLR1B(1), POLR2A(2), POLR3B(1), TAF5(1) 13646924 7 7 7 11 2 1 0 3 1 0 1.000 1.000 1.000 592 STRESSPATHWAY Tumor necrosis factor receptor TNFR1 promotes apoptosis and activates the pro-inflammatory NF-kB, while TNFR2 activates stress-activated protein kinases (SAPKs). ATF1, CASP2, CHUK, CRADD, IKBKB, IKBKG, JUN, LTA, MAP2K3, MAP2K4, MAP2K6, MAP3K1, MAP3K14, MAP4K2, MAPK14, MAPK8, NFKB1, NFKBIA, RELA, RIPK1, TANK, TNF, TNFRSF1A, TRADD, TRAF2 24 MAP2K4(1), RELA(2), RIPK1(1), TNF(1), TRAF2(3) 9457968 8 7 8 5 2 1 2 3 0 0 0.858 1.000 1.000 593 CFTRPATHWAY The cAMP-regulated chloride channel CFTR (deficient in cystic fibrosis) is regulated by the surface-localized beta-adrenergic receptor. ADCY1, ADRB2, CFTR, GNAS, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, SLC9A3R1, VIL2 11 ADCY1(1), CFTR(1), GNAS(2), PRKAR1A(1), PRKAR1B(1) 5107439 6 6 6 7 0 1 0 5 0 0 0.998 1.000 1.000 594 TOB1PATHWAY TGF-beta signaling activates SMADs, which interact with intracellular Tob to maintain unstimulated T cells by repressing IL-2 expression. CD28, CD3D, CD3E, CD3G, CD3Z, IFNG, IL2, IL2RA, IL4, MADH3, MADH4, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TGFBR3, TOB1, TOB2, TRA@, TRB@ 16 IL4(1), TGFB1(1), TGFB2(1), TGFBR1(2), TGFBR3(1) 4132422 6 6 6 4 1 1 2 2 0 0 0.880 1.000 1.000 595 HSA00220_UREA_CYCLE_AND_METABOLISM_OF_AMINO_GROUPS Genes involved in urea cycle and metabolism of amino groups ABP1, ACY1, ADC, AGMAT, ALDH18A1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, AMD1, AOC2, AOC3, ARG1, ARG2, ASL, ASS1, CPS1, GATM, MAOA, MAOB, NAGS, ODC1, OTC, SAT1, SAT2, SMS, SRM 30 ALDH18A1(1), ALDH1A3(1), ALDH3A1(1), AOC2(1), ARG2(1) 11497653 5 5 5 9 1 0 1 3 0 0 1.000 1.000 1.000 596 HSA00533_KERATAN_SULFATE_BIOSYNTHESIS Genes involved in keratan sulfate biosynthesis B3GNT1, B3GNT2, B3GNT7, B4GALT1, B4GALT2, B4GALT3, B4GALT4, CHST1, CHST2, CHST4, CHST6, FUT8, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4 16 B3GNT7(1), B4GALT1(2), B4GALT2(1), CHST4(1), ST3GAL1(2) 4886960 7 5 7 4 6 1 0 0 0 0 0.823 1.000 1.000 597 UREA_CYCLE_AND_METABOLISM_OF_AMINO_GROUPS ACY1, ALDH18A1, ARG1, ARG2, ASL, ASS, CKB, CKM, CKMT1, CKMT1B, CKMT1A, CKMT2, CPS1, GAMT, GATM, GLUD1, NAGS, OAT, ODC1, OTC, PYCR1, SMS 20 ALDH18A1(1), ARG2(1), CKB(1), CKMT2(2) 6862442 5 5 5 7 2 0 1 2 0 0 0.994 1.000 1.000 598 HSA00791_ATRAZINE_DEGRADATION Genes involved in atrazine degradation ADAR, APOBEC1, APOBEC2, APOBEC3A, APOBEC3B, APOBEC3C, APOBEC3F, APOBEC3G, APOBEC4 9 ADAR(1), APOBEC1(1), APOBEC3B(2) 2854084 4 4 4 3 2 1 0 1 0 0 0.916 1.000 1.000 599 HSA00053_ASCORBATE_AND_ALDARATE_METABOLISM Genes involved in ascorbate and aldarate metabolism ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, MIOX, UGDH 9 ALDH1A3(1), ALDH3A1(1), UGDH(1) 3338245 3 3 3 4 0 0 2 1 0 0 0.983 1.000 1.000 600 BIOSYNTHESIS_OF_STEROIDS DHCR7, FDFT1, FDPS, FDPS, LOC402397, HMGCR, IDI1, LSS, MVD, MVK, NQO1, NQO2, PMVK, SC5DL, SQLE, VKORC1 14 NQO1(1), SQLE(1) 4329877 2 2 2 4 2 0 0 0 0 0 0.988 1.000 1.000 601 HSA00520_NUCLEOTIDE_SUGARS_METABOLISM Genes involved in nucleotide sugars metabolism GALE, GALT, TGDS, UGDH, UGP2, UXS1 6 UGDH(1), UGP2(1) 1914236 2 2 2 2 0 0 1 1 0 0 0.938 1.000 1.000 602 NOTCHPATHWAY Proteolysis and Signaling Pathway of Notch ADAM17, DLL1, FURIN, NOTCH1, PSEN1, RBPSUH 5 NOTCH1(2) 3722814 2 2 2 3 0 1 1 0 0 0 0.941 1.000 1.000 603 CHOLESTEROL_BIOSYNTHESIS C10orf110, CYP51A1, DHCR7, FDFT1, FDPS, FDPS, LOC402397, HMGCR, HMGCS1, IDI1, LSS, MVD, MVK, NSDHL, PMVK, SC4MOL, SC5DL, SQLE 15 SQLE(1) 5152381 1 1 1 5 1 0 0 0 0 0 0.999 1.000 1.000 604 FXRPATHWAY The nuclear receptor transcription factors FXR and LXR are activated by cholesterol metabolites and regulate cholesterol homeostasis. FABP6, LDLR, NR0B2, NR1H3, NR1H4, RXRA 6 LDLR(1) 2123138 1 1 1 3 1 0 0 0 0 0 0.993 1.000 1.000 605 HSA00550_PEPTIDOGLYCAN_BIOSYNTHESIS Genes involved in peptidoglycan biosynthesis GLUL, PGLYRP2 2 PGLYRP2(1) 717133 1 1 1 2 0 0 0 1 0 0 0.985 1.000 1.000 606 HSA00950_ALKALOID_BIOSYNTHESIS_I Genes involved in alkaloid biosynthesis I DDC, GOT1, GOT2, TAT, TYR 5 GOT1(1) 1829183 1 1 1 2 0 0 0 1 0 0 0.982 1.000 1.000 607 NUCLEOTIDE_SUGARS_METABOLISM GALE, GALT, TGDS, UGDH, UXS1 5 UGDH(1) 1505542 1 1 1 2 0 0 1 0 0 0 0.972 1.000 1.000 608 UBIQUITIN_MEDIATED_PROTEOLYSIS CDC34, HIP2, NRF1, UBE1, UBE2A, UBE2B, UBE2C, UBE2D1, UBE2D2, UBE2D3, UBE2E1, UBE2E3, UBE2G1, UBE2G2, UBE2G2, TAX1BP3, UBE2H, UBE2I, UBE2J1, UBE2J2, UBE2L3, UBE2L6, UBE2M, UBE2N, UBE2S, UBE3A 23 UBE2I(1) 4107065 1 1 1 2 0 1 0 0 0 0 0.980 1.000 1.000 609 UREACYCLEPATHWAY Ammonia released from amino acid deamination is used to produce carbamoyl phosphate, which is used to convert ornithine to citrulline, from which urea is eventually formed. ARG1, ASL, ASS, CPS1, GLS, GLUD1, GOT1 6 GOT1(1) 3036045 1 1 1 4 0 0 0 1 0 0 0.999 1.000 1.000 610 HSA00031_INOSITOL_METABOLISM Genes involved in inositol metabolism ALDH6A1, TPI1 2 642057 0 0 0 0 0 0 0 0 0 0 1.000 1.000 1.000 611 HSA00471_D_GLUTAMINE_AND_D_GLUTAMATE_METABOLISM Genes involved in D-glutamine and D-glutamate metabolism GLS, GLS2, GLUD1, GLUD2 4 1775527 0 0 0 0 0 0 0 0 0 0 1.000 1.000 1.000 612 HSA00902_MONOTERPENOID_BIOSYNTHESIS Genes involved in monoterpenoid biosynthesis CYP2C19, CYP2C9 2 785675 0 0 0 0 0 0 0 0 0 0 1.000 1.000 1.000 613 PEPIPATHWAY Proepithelin (PEPI) induces epithelial cells to secrete IL-8, which promotes elastase secretion by neutrophils. ELA1, ELA2, ELA2A, ELA2B, ELA3B, GRN, IL8, SLPI 3 665789 0 0 0 0 0 0 0 0 0 0 1.000 1.000 1.000 614 SARSPATHWAY The SARS coronavirus has a 30kb RNA genome containing rep, a large gene encoding viral protease Mpro. ANPEP, CKM, EIF4E, FBL, GPT, LDHA, LDHB, LDHC, MAPK14, NCL 10 3490639 0 0 0 1 0 0 0 0 0 0 1.000 1.000 1.000 615 TCAPOPTOSISPATHWAY HIV infection upregulates Fas ligand in macrophages and CD4 in helper T cells, leading to widespread Fas-induced T cell apoptosis. CCR5, CD28, CD3D, CD3E, CD3G, CD3Z, CD4, TNFRSF6, TNFSF6, TRA@, TRB@ 6 1248585 0 0 0 1 0 0 0 0 0 0 1.000 1.000 1.000 616 TCRMOLECULE T Cell Receptor and CD3 Complex CD3D, CD3E, CD3G, CD3Z, TRA@, TRB@ 3 442966 0 0 0 1 0 0 0 0 0 0 1.000 1.000 1.000