Neurotrophic factor-mediated Trk receptor signaling Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations CRKL 0.013 0.0 -9999.0 0.0 -9999.0 0.0 0.0 RAS family/GTP/Tiam1 -0.018 0.096 -9999.0 0.0 -0.256 42.0 42.0 NT3 (dimer)/TRKC -0.085 0.201 -9999.0 0.0 -0.432 112.0 112.0 NT3 (dimer)/TRKB -0.072 0.188 -9999.0 0.0 -0.37 121.0 121.0 SHC/Grb2/SOS1/GAB1/PI3K 0.031 0.036 -9999.0 0.0 -0.434 1.0 1.0 RAPGEF1 0.013 0.0 -9999.0 0.0 -9999.0 0.0 0.0 BDNF -0.088 0.197 -9999.0 0.0 -0.471 102.0 102.0 PIK3CA 0.01 0.038 -9999.0 0.0 -0.471 3.0 3.0 DYNLT1 0.013 0.001 -9999.0 0.0 -9999.0 0.0 0.0 NTRK1 -0.029 0.14 -9999.0 0.0 -0.494 40.0 40.0 NTRK2 -0.056 0.17 -9999.0 0.0 -0.472 69.0 69.0 NTRK3 -0.081 0.192 -9999.0 0.0 -0.471 95.0 95.0 NT-4/5 (dimer)/TRKB -0.104 0.21 -9999.0 0.0 -0.375 158.0 158.0 neuron apoptosis 0.076 0.19 0.496 60.0 -9999.0 0.0 60.0 SHC 2-3/Grb2 -0.084 0.211 -9999.0 0.0 -0.551 60.0 60.0 SHC1 0.013 0.0 -9999.0 0.0 -9999.0 0.0 0.0 SHC2 -0.088 0.165 -9999.0 0.0 -0.493 52.0 52.0 SHC3 -0.118 0.214 -9999.0 0.0 -0.564 73.0 73.0 STAT3 (dimer) 0.02 0.012 -9999.0 0.0 -9999.0 0.0 0.0 NT3 (dimer)/TRKA -0.057 0.169 -9999.0 0.0 -0.343 110.0 110.0 RIN/GDP -0.011 0.097 -9999.0 0.0 -0.251 23.0 23.0 GIPC1 0.013 0.0 -9999.0 0.0 -9999.0 0.0 0.0 KRAS 0.013 0.0 -9999.0 0.0 -9999.0 0.0 0.0 DNAJA3 -0.029 0.121 -9999.0 0.0 -0.345 43.0 43.0 RIN/GTP -0.024 0.11 -9999.0 0.0 -0.424 34.0 34.0 CCND1 0.028 0.022 -9999.0 0.0 -0.466 1.0 1.0 MAGED1 0.012 0.027 -9999.0 0.0 -0.576 1.0 1.0 PTPN11 0.012 0.022 -9999.0 0.0 -0.471 1.0 1.0 RICS 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 NT-4/5 (dimer) -0.099 0.204 -9999.0 0.0 -0.47 113.0 113.0 SHC/GRB2/SOS1 0.027 0.0 -9999.0 0.0 -9999.0 0.0 0.0 GRB2 0.013 0.0 -9999.0 0.0 -9999.0 0.0 0.0 NGF (dimer)/TRKA/MATK -0.179 0.21 -9999.0 0.0 -0.371 251.0 251.0 TRKA/NEDD4-2 -0.024 0.132 -9999.0 0.0 -0.398 51.0 51.0 ELMO1 0.01 0.038 -9999.0 0.0 -0.471 3.0 3.0 RhoG/GTP/ELMO1/DOCK1 0.014 0.033 -9999.0 0.0 -0.276 6.0 6.0 NGF -0.009 0.103 -9999.0 0.0 -0.48 22.0 22.0 HRAS 0.007 0.059 -9999.0 0.0 -0.576 5.0 5.0 DOCK1 0.01 0.038 -9999.0 0.0 -0.471 3.0 3.0 GAB2 0.013 0.0 -9999.0 0.0 -9999.0 0.0 0.0 RIT2 -0.033 0.149 -9999.0 0.0 -0.576 34.0 34.0 RIT1 0.013 0.0 -9999.0 0.0 -9999.0 0.0 0.0 FRS2 0.013 0.0 -9999.0 0.0 -9999.0 0.0 0.0 DNM1 0.011 0.035 -9999.0 0.0 -0.523 2.0 2.0 mol:GTP 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 CRK 0.013 0.0 -9999.0 0.0 -9999.0 0.0 0.0 SH2B1 (homopentamer) 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 RhoG/GTP -0.029 0.12 -9999.0 0.0 -0.34 43.0 43.0 mol:GDP -0.003 0.12 -9999.0 0.0 -0.346 21.0 21.0 NGF (dimer) -0.009 0.103 -9999.0 0.0 -0.48 22.0 22.0 RhoG/GDP 0.008 0.027 -9999.0 0.0 -0.337 3.0 3.0 RIT1/GDP 0.006 0.085 -9999.0 0.0 -0.235 15.0 15.0 TIAM1 0.01 0.038 -9999.0 0.0 -0.471 3.0 3.0 PIK3R1 0.008 0.049 -9999.0 0.0 -0.471 5.0 5.0 BDNF (dimer)/TRKB -0.074 0.182 -9999.0 0.0 -0.363 126.0 126.0 KIDINS220/CRKL/C3G 0.02 0.0 -9999.0 0.0 -9999.0 0.0 0.0 SHC/RasGAP 0.017 0.027 -9999.0 0.0 -0.328 3.0 3.0 FRS2 family/SHP2 0.026 0.013 -9999.0 0.0 -0.269 1.0 1.0 SHC/GRB2/SOS1/GAB1 0.034 0.012 -9999.0 0.0 -9999.0 0.0 0.0 RIT1/GTP 0.01 0.0 -9999.0 0.0 -9999.0 0.0 0.0 NT3 (dimer) -0.045 0.157 -9999.0 0.0 -0.47 58.0 58.0 RAP1/GDP -0.027 0.053 -9999.0 0.0 -0.224 1.0 1.0 KIDINS220/CRKL 0.013 0.0 -9999.0 0.0 -9999.0 0.0 0.0 BDNF (dimer) -0.088 0.197 -9999.0 0.0 -0.47 102.0 102.0 ubiquitin-dependent protein catabolic process -0.025 0.129 -9999.0 0.0 -0.323 71.0 71.0 Schwann cell development -0.026 0.034 -9999.0 0.0 -9999.0 0.0 0.0 EHD4 0.013 0.0 -9999.0 0.0 -9999.0 0.0 0.0 FRS2 family/GRB2/SOS1 0.034 0.0 -9999.0 0.0 -9999.0 0.0 0.0 FRS2 family/SHP2/CRK family/C3G/GAB2 0.037 0.011 -9999.0 0.0 -9999.0 0.0 0.0 RAP1B 0.013 0.0 -9999.0 0.0 -9999.0 0.0 0.0 RAP1A 0.013 0.0 -9999.0 0.0 -9999.0 0.0 0.0 CDC42/GTP -0.13 0.21 -9999.0 0.0 -0.535 85.0 85.0 ABL1 0.013 0.0 -9999.0 0.0 -9999.0 0.0 0.0 SH2B family/GRB2/SOS1 0.02 0.0 -9999.0 0.0 -9999.0 0.0 0.0 Rap1/GTP 0.004 0.079 -9999.0 0.0 -9999.0 0.0 0.0 STAT3 0.02 0.012 -9999.0 0.0 -9999.0 0.0 0.0 axon guidance -0.124 0.199 -9999.0 0.0 -0.508 85.0 85.0 MAPK3 -0.156 0.191 -9999.0 0.0 -0.34 228.0 228.0 MAPK1 -0.156 0.191 -9999.0 0.0 -0.34 228.0 228.0 CDC42/GDP 0.006 0.085 -9999.0 0.0 -0.24 12.0 12.0 NTF3 -0.045 0.157 -9999.0 0.0 -0.471 58.0 58.0 NTF4 -0.1 0.204 -9999.0 0.0 -0.471 113.0 113.0 NGF (dimer)/TRKA/FAIM -0.013 0.108 -9999.0 0.0 -0.293 61.0 61.0 PI3K 0.014 0.048 -9999.0 0.0 -0.369 7.0 7.0 FRS3 0.013 0.001 -9999.0 0.0 -9999.0 0.0 0.0 FAIM 0.012 0.027 -9999.0 0.0 -0.576 1.0 1.0 GAB1 0.012 0.022 -9999.0 0.0 -0.471 1.0 1.0 RASGRF1 -0.073 0.168 -9999.0 0.0 -0.432 61.0 61.0 SOS1 0.013 0.0 -9999.0 0.0 -9999.0 0.0 0.0 MCF2L -0.064 0.174 -9999.0 0.0 -0.363 112.0 112.0 RGS19 0.012 0.027 -9999.0 0.0 -0.576 1.0 1.0 CDC42 0.013 0.0 -9999.0 0.0 -9999.0 0.0 0.0 RAS family/GTP 0.017 0.066 -9999.0 0.0 -9999.0 0.0 0.0 Rac1/GDP 0.006 0.085 -9999.0 0.0 -0.232 17.0 17.0 NGF (dimer)/TRKA/GRIT -0.021 0.106 -9999.0 0.0 -0.3 60.0 60.0 neuron projection morphogenesis -0.016 0.12 -9999.0 0.0 -0.47 15.0 15.0 NGF (dimer)/TRKA/NEDD4-2 -0.025 0.13 -9999.0 0.0 -0.324 71.0 71.0 MAP2K1 0.035 0.011 -9999.0 0.0 -9999.0 0.0 0.0 NGFR -0.028 0.135 -9999.0 0.0 -0.471 41.0 41.0 NGF (dimer)/TRKA/GIPC/GAIP 0.004 0.082 -9999.0 0.0 -0.434 2.0 2.0 RAS family/GTP/PI3K 0.023 0.045 -9999.0 0.0 -0.426 3.0 3.0 FRS2 family/SHP2/GRB2/SOS1 0.039 0.012 -9999.0 0.0 -9999.0 0.0 0.0 NRAS 0.012 0.022 -9999.0 0.0 -0.471 1.0 1.0 GRB2/SOS1 0.02 0.0 -9999.0 0.0 -9999.0 0.0 0.0 PRKCI 0.012 0.027 -9999.0 0.0 -0.576 1.0 1.0 ChemicalAbstracts:146-91-8 -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 RAC1 0.013 0.0 -9999.0 0.0 -9999.0 0.0 0.0 PRKCZ 0.013 0.0 -9999.0 0.0 -9999.0 0.0 0.0 MAPKKK cascade -0.079 0.192 -9999.0 0.0 -0.625 49.0 49.0 RASA1 0.01 0.038 -9999.0 0.0 -0.471 3.0 3.0 TRKA/c-Abl -0.011 0.102 -9999.0 0.0 -0.348 40.0 40.0 SQSTM1 0.013 0.0 -9999.0 0.0 -9999.0 0.0 0.0 BDNF (dimer)/TRKB/GIPC -0.059 0.168 -9999.0 0.0 -0.479 46.0 46.0 NGF (dimer)/TRKA/p62/Atypical PKCs 0.005 0.093 -9999.0 0.0 -0.452 2.0 2.0 MATK -0.252 0.293 -9999.0 0.0 -0.575 219.0 219.0 NEDD4L -0.006 0.105 -9999.0 0.0 -0.576 16.0 16.0 RAS family/GDP -0.026 0.052 -9999.0 0.0 -0.232 3.0 3.0 NGF (dimer)/TRKA -0.053 0.119 -9999.0 0.0 -0.365 44.0 44.0 Rac1/GTP -0.066 0.104 -9999.0 0.0 -0.326 46.0 46.0 FRS2 family/SHP2/CRK family 0.039 0.012 -9999.0 0.0 -9999.0 0.0 0.0