ErbB4 signaling events Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations ErbB4/ErbB4/HBEGF/HBEGF 0.011 0.075 -9999.0 0.0 -0.349 12.0 12.0 epithelial cell differentiation -0.032 0.077 -9999.0 0.0 -0.405 5.0 5.0 ITCH 0.018 0.013 -9999.0 0.0 -9999.0 0.0 0.0 WWP1 0.018 0.054 -9999.0 0.0 -0.561 1.0 1.0 FYN 0.013 0.001 -9999.0 0.0 -9999.0 0.0 0.0 EGFR -0.026 0.131 -9999.0 0.0 -0.471 39.0 39.0 PRL -0.003 0.052 -9999.0 0.0 -0.576 4.0 4.0 neuron projection morphogenesis -0.018 0.123 -9999.0 0.0 -0.408 11.0 11.0 PTPRZ1 -0.163 0.236 -9999.0 0.0 -0.478 174.0 174.0 ErbB4/ErbB4/neuregulin 1 beta/neuregulin 1 beta/GRB2/SHC -0.033 0.132 -9999.0 0.0 -0.456 11.0 11.0 ErbB4 CYT2/ErbB4 CYT2/neuregulin 1 beta/neuregulin 1 beta -0.055 0.139 -9999.0 0.0 -0.349 36.0 36.0 ADAM17 0.012 0.049 -9999.0 0.0 -0.458 5.0 5.0 ErbB4/ErbB4 0.015 0.068 -9999.0 0.0 -0.431 4.0 4.0 ErbB4/ErbB4/neuregulin 3/neuregulin 3 -0.026 0.11 -9999.0 0.0 -0.361 25.0 25.0 NCOR1 0.012 0.022 -9999.0 0.0 -0.471 1.0 1.0 ErbB4/ErbB4/neuregulin 1 beta/neuregulin 1 beta/Fyn -0.044 0.131 -9999.0 0.0 -0.327 33.0 33.0 GRIN2B -0.041 0.125 -9999.0 0.0 -0.566 2.0 2.0 ErbB4/ErbB2/betacellulin 0.009 0.1 -9999.0 0.0 -0.402 18.0 18.0 STAT1 0.001 0.084 -9999.0 0.0 -0.576 10.0 10.0 HBEGF 0.002 0.078 -9999.0 0.0 -0.534 10.0 10.0 PRLR -0.042 0.164 -9999.0 0.0 -0.525 50.0 50.0 E4ICDs/ETO2 0.015 0.065 -9999.0 0.0 -0.378 5.0 5.0 axon guidance 0.033 0.077 -9999.0 0.0 -0.3 2.0 2.0 NEDD4 0.007 0.068 -9999.0 0.0 -0.458 10.0 10.0 Prolactin receptor/Prolactin receptor/Prolactin -0.033 0.125 -9999.0 0.0 -0.383 54.0 54.0 CBFA2T3 0.008 0.049 -9999.0 0.0 -0.471 5.0 5.0 ErbB4/ErbB2/HBEGF 0.018 0.073 -9999.0 0.0 -0.366 6.0 6.0 MAPK3 -0.025 0.126 -9999.0 0.0 -0.426 11.0 11.0 STAT1 (dimer) 0.01 0.079 -9999.0 0.0 -0.364 14.0 14.0 MAPK1 -0.025 0.126 -9999.0 0.0 -0.426 11.0 11.0 JAK2 0.012 0.022 -9999.0 0.0 -0.471 1.0 1.0 ErbB4/ErbB2/neuregulin 1 beta -0.047 0.134 -9999.0 0.0 -0.344 34.0 34.0 NRG1 -0.081 0.162 -9999.0 0.0 -0.332 142.0 142.0 NRG3 -0.048 0.162 -9999.0 0.0 -0.508 53.0 53.0 NRG2 -0.158 0.231 -9999.0 0.0 -0.471 172.0 172.0 NRG4 -0.151 0.231 -9999.0 0.0 -0.476 163.0 163.0 heart development 0.033 0.077 -9999.0 0.0 -0.3 2.0 2.0 neural crest cell migration -0.046 0.133 -9999.0 0.0 -0.341 34.0 34.0 ERBB2 0.017 0.047 -9999.0 0.0 -0.317 9.0 9.0 WWOX/E4ICDs 0.017 0.06 -9999.0 0.0 -0.377 4.0 4.0 SHC1 0.013 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ErbB4/EGFR/neuregulin 4 -0.083 0.169 -9999.0 0.0 -0.467 40.0 40.0 apoptosis 0.029 0.111 0.345 38.0 -9999.0 0.0 38.0 ErbB4/ErbB4/neuregulin 2 beta/neuregulin 2 beta -0.08 0.156 -9999.0 0.0 -0.396 41.0 41.0 ErbB4/ErbB2/epiregulin -0.01 0.098 -9999.0 0.0 -0.401 6.0 6.0 ErbB4/ErbB4/betacellulin/betacellulin 0.0 0.104 -9999.0 0.0 -0.433 17.0 17.0 ErbB4/ErbB4/HBEGF/HBEGF/Prolactin receptor/Prolactin receptor/Prolactin/JAK2 -0.006 0.117 -9999.0 0.0 -0.439 12.0 12.0 MDM2 0.02 0.059 -9999.0 0.0 -0.377 4.0 4.0 ErbB4 JM-B/ErbB4 JM-B/neuregulin 1 beta/neuregulin 1 beta -0.048 0.128 -9999.0 0.0 -0.309 33.0 33.0 STAT5A 0.041 0.072 -9999.0 0.0 -9999.0 0.0 0.0 ErbB4/EGFR/neuregulin 1 beta -0.064 0.157 -9999.0 0.0 -0.391 50.0 50.0 DLG4 0.001 0.075 -9999.0 0.0 -0.471 12.0 12.0 GRB2/SHC 0.02 0.0 -9999.0 0.0 -9999.0 0.0 0.0 E4ICDs/TAB2/NCoR1 0.015 0.058 -9999.0 0.0 -0.411 4.0 4.0 STAT5A (dimer) -0.033 0.082 -9999.0 0.0 -0.434 5.0 5.0 MAP3K7IP2 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 STAT5B (dimer) 0.04 0.068 -9999.0 0.0 -9999.0 0.0 0.0 LRIG1 0.012 0.027 -9999.0 0.0 -0.576 1.0 1.0 EREG -0.041 0.156 -9999.0 0.0 -0.515 47.0 47.0 BTC -0.018 0.119 -9999.0 0.0 -0.474 31.0 31.0 ErbB4/ErbB4/neuregulin 1 beta/neuregulin 1 beta 0.031 0.076 -9999.0 0.0 -0.302 2.0 2.0 ERBB4 0.015 0.068 -9999.0 0.0 -0.433 4.0 4.0 STAT5B 0.013 0.0 -9999.0 0.0 -9999.0 0.0 0.0 YAP1 0.011 0.067 -9999.0 0.0 -0.717 4.0 4.0 GRB2 0.013 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ErbB4/ErbB2/neuregulin 4 -0.061 0.139 -9999.0 0.0 -0.373 27.0 27.0 glial cell differentiation -0.015 0.057 0.407 4.0 -9999.0 0.0 4.0 WWOX 0.012 0.022 -9999.0 0.0 -0.471 1.0 1.0 cell proliferation -0.06 0.165 -9999.0 0.0 -0.496 25.0 25.0