Signaling events mediated by the Hedgehog family Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations TGFB2 0.003 0.161 -9999.0 0.0 -0.648 22.0 22.0 IHH -0.038 0.173 -9999.0 0.0 -0.532 52.0 52.0 SHH Np/Cholesterol/GAS1 -0.088 0.163 -9999.0 0.0 -0.299 167.0 167.0 LRPAP1 0.013 0.0 -9999.0 0.0 -9999.0 0.0 0.0 dorsoventral neural tube patterning 0.087 0.162 0.298 167.0 -9999.0 0.0 167.0 SMO/beta Arrestin2 0.002 0.114 -9999.0 0.0 -0.454 15.0 15.0 SMO -0.005 0.12 -9999.0 0.0 -0.462 18.0 18.0 AKT1 0.014 0.08 -9999.0 0.0 -0.508 5.0 5.0 ARRB2 0.013 0.0 -9999.0 0.0 -9999.0 0.0 0.0 BOC 0.001 0.075 -9999.0 0.0 -0.471 12.0 12.0 ADRBK1 0.013 0.0 -9999.0 0.0 -9999.0 0.0 0.0 heart looping -0.005 0.118 -9999.0 0.0 -0.456 18.0 18.0 STIL -0.064 0.167 -9999.0 0.0 -0.463 37.0 37.0 DHH N/PTCH2 0.008 0.067 -9999.0 0.0 -0.363 15.0 15.0 DHH N/PTCH1 0.004 0.112 -9999.0 0.0 -0.441 13.0 13.0 PIK3CA 0.01 0.038 -9999.0 0.0 -0.471 3.0 3.0 DHH 0.003 0.073 -9999.0 0.0 -0.502 10.0 10.0 PTHLH -0.003 0.198 -9999.0 0.0 -0.815 22.0 22.0 determination of left/right symmetry -0.005 0.118 -9999.0 0.0 -0.456 18.0 18.0 PIK3R1 0.008 0.049 -9999.0 0.0 -0.471 5.0 5.0 skeletal system development -0.002 0.196 -9999.0 0.0 -0.804 22.0 22.0 IHH N/Hhip -0.05 0.163 -9999.0 0.0 -0.378 91.0 91.0 DHH N/Hhip -0.024 0.118 -9999.0 0.0 -0.337 60.0 60.0 mol:Cholesterol 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 heart development -0.005 0.118 -9999.0 0.0 -0.456 18.0 18.0 pancreas development -0.037 0.149 -9999.0 0.0 -0.476 50.0 50.0 HHAT 0.005 0.062 -9999.0 0.0 -0.471 8.0 8.0 PI3K 0.014 0.048 -9999.0 0.0 -0.369 7.0 7.0 EntrezGene:84976 -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 GAS1 -0.039 0.15 -9999.0 0.0 -0.473 52.0 52.0 somite specification -0.005 0.118 -9999.0 0.0 -0.456 18.0 18.0 SHH Np/Cholesterol/PTCH1 -0.059 0.158 -9999.0 0.0 -0.466 27.0 27.0 SHH Np/Cholesterol/PTCH2 -0.063 0.14 -9999.0 0.0 -0.28 138.0 138.0 SHH Np/Cholesterol/Megalin -0.091 0.163 -9999.0 0.0 -0.299 171.0 171.0 SHH -0.087 0.176 -9999.0 0.0 -0.368 135.0 135.0 catabolic process 0.004 0.115 -9999.0 0.0 -0.478 11.0 11.0 SMO/Vitamin D3 -0.05 0.159 -9999.0 0.0 -0.474 26.0 26.0 SHH Np/Cholesterol/Hhip -0.087 0.169 -9999.0 0.0 -0.317 157.0 157.0 LRP2 -0.043 0.159 -9999.0 0.0 -0.49 54.0 54.0 receptor-mediated endocytosis -0.065 0.172 -9999.0 0.0 -0.475 38.0 38.0 SHH Np/Cholesterol/BOC -0.066 0.144 -9999.0 0.0 -0.334 62.0 62.0 SHH Np/Cholesterol/CDO -0.064 0.141 -9999.0 0.0 -0.328 62.0 62.0 mesenchymal cell differentiation 0.086 0.168 0.315 157.0 -9999.0 0.0 157.0 mol:Vitamin D3 -0.057 0.159 -9999.0 0.0 -0.462 28.0 28.0 IHH N/PTCH2 -0.016 0.114 -9999.0 0.0 -0.324 56.0 56.0 CDON 0.006 0.063 -9999.0 0.0 -0.558 6.0 6.0 IHH N/PTCH1 0.005 0.117 -9999.0 0.0 -0.483 11.0 11.0 Megalin/LRPAP1 -0.021 0.115 -9999.0 0.0 -0.344 54.0 54.0 PTCH2 0.008 0.055 -9999.0 0.0 -0.534 5.0 5.0 SHH Np/Cholesterol -0.068 0.136 -9999.0 0.0 -0.283 135.0 135.0 PTCH1 0.004 0.115 -9999.0 0.0 -0.48 11.0 11.0 HHIP -0.037 0.149 -9999.0 0.0 -0.477 50.0 50.0