Stabilization and expansion of the E-cadherin adherens junction Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations adherens junction organization 0.028 0.015 -9999.0 0.0 -0.211 2.0 2.0 epithelial cell differentiation 0.027 0.016 -9999.0 0.0 -9999.0 0.0 0.0 CYFIP2 0.013 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ENAH 0.038 0.056 -9999.0 0.0 -9999.0 0.0 0.0 EGFR -0.026 0.131 -9999.0 0.0 -0.471 39.0 39.0 EPHA2 -0.036 0.148 -9999.0 0.0 -0.477 49.0 49.0 MYO6 -0.0 0.098 -9999.0 0.0 -0.279 52.0 52.0 CTNNB1 0.013 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ABI1/Sra1/Nap1 0.027 0.0 -9999.0 0.0 -9999.0 0.0 0.0 AQP5 -0.176 0.198 -9999.0 0.0 -0.4 213.0 213.0 CTNND1 0.013 0.0 -9999.0 0.0 -9999.0 0.0 0.0 mol:PI-4-5-P2 0.033 0.015 -9999.0 0.0 -9999.0 0.0 0.0 regulation of calcium-dependent cell-cell adhesion 0.023 0.05 -9999.0 0.0 -0.271 3.0 3.0 EGF -0.056 0.183 -9999.0 0.0 -0.538 61.0 61.0 NCKAP1 0.013 0.0 -9999.0 0.0 -9999.0 0.0 0.0 AQP3 -0.011 0.065 -9999.0 0.0 -0.399 13.0 13.0 cortical microtubule organization 0.027 0.016 -9999.0 0.0 -9999.0 0.0 0.0 GO:0000145 0.031 0.014 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin 0.03 0.016 -9999.0 0.0 -9999.0 0.0 0.0 MLLT4 0.013 0.001 -9999.0 0.0 -9999.0 0.0 0.0 ARF6/GDP -0.018 0.051 -9999.0 0.0 -9999.0 0.0 0.0 ARF6 0.013 0.0 -9999.0 0.0 -9999.0 0.0 0.0 Ephrin A1/EPHA2/NCK1/GIT1 0.006 0.084 -9999.0 0.0 -0.31 4.0 4.0 mol:Ca2+ -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 VASP 0.03 0.046 -9999.0 0.0 -9999.0 0.0 0.0 PVRL2 0.013 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ZYX 0.033 0.015 -9999.0 0.0 -9999.0 0.0 0.0 ARF6/GTP 0.011 0.078 -9999.0 0.0 -0.282 4.0 4.0 CDH1 0.011 0.031 -9999.0 0.0 -0.471 2.0 2.0 EGFR/EGFR/EGF/EGF -0.046 0.093 -9999.0 0.0 -0.417 3.0 3.0 RhoA/GDP -0.001 0.013 -9999.0 0.0 -9999.0 0.0 0.0 actin cytoskeleton organization -0.006 0.102 -9999.0 0.0 -0.462 3.0 3.0 IGF-1R heterotetramer 0.011 0.034 -9999.0 0.0 -0.522 2.0 2.0 GIT1 0.013 0.0 -9999.0 0.0 -9999.0 0.0 0.0 IGF1R 0.011 0.035 -9999.0 0.0 -0.523 2.0 2.0 IGF1 -0.046 0.166 -9999.0 0.0 -0.509 55.0 55.0 DIAPH1 0.002 0.005 -9999.0 0.0 -9999.0 0.0 0.0 Wnt receptor signaling pathway -0.027 0.016 -9999.0 0.0 -9999.0 0.0 0.0 RHOA 0.013 0.0 -9999.0 0.0 -9999.0 0.0 0.0 RhoA/GTP -0.017 0.051 -9999.0 0.0 -9999.0 0.0 0.0 CTNNA1 0.013 0.0 -9999.0 0.0 -9999.0 0.0 0.0 VCL -0.006 0.104 -9999.0 0.0 -0.474 3.0 3.0 EFNA1 0.013 0.0 -9999.0 0.0 -9999.0 0.0 0.0 LPP 0.019 0.065 -9999.0 0.0 -9999.0 0.0 0.0 Ephrin A1/EPHA2 -0.021 0.061 -9999.0 0.0 -9999.0 0.0 0.0 SEC6/SEC8 -0.001 0.011 -9999.0 0.0 -9999.0 0.0 0.0 MGAT3 0.023 0.051 -9999.0 0.0 -0.275 3.0 3.0 HGF/MET -0.036 0.096 -9999.0 0.0 -0.417 17.0 17.0 HGF -0.026 0.136 -9999.0 0.0 -0.499 37.0 37.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin/EPLIN 0.028 0.015 -9999.0 0.0 -0.212 2.0 2.0 actin cable formation 0.05 0.053 -9999.0 0.0 -9999.0 0.0 0.0 KIAA1543 0.038 0.018 -9999.0 0.0 -9999.0 0.0 0.0 KIFC3 0.032 0.024 -9999.0 0.0 -9999.0 0.0 0.0 NCK1 0.012 0.027 -9999.0 0.0 -0.576 1.0 1.0 EXOC3 0.013 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ACTN1 0.03 0.031 -9999.0 0.0 -9999.0 0.0 0.0 NCK1/GIT1 0.019 0.02 -9999.0 0.0 -0.416 1.0 1.0 mol:GDP 0.027 0.016 -9999.0 0.0 -9999.0 0.0 0.0 EXOC4 0.013 0.0 -9999.0 0.0 -9999.0 0.0 0.0 STX4 0.033 0.015 -9999.0 0.0 -9999.0 0.0 0.0 PIP5K1C 0.033 0.015 -9999.0 0.0 -9999.0 0.0 0.0 LIMA1 0.013 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ABI1 0.013 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ROCK1 0.034 0.062 -9999.0 0.0 -9999.0 0.0 0.0 adherens junction assembly 0.049 0.032 -9999.0 0.0 -9999.0 0.0 0.0 IGF-1R heterotetramer/IGF1 -0.026 0.075 -9999.0 0.0 -0.481 2.0 2.0 nectin-2(dimer)/I-afadin/I-afadin/nectin-2(dimer/I-afadin/I-afadin 0.02 0.0 -9999.0 0.0 -9999.0 0.0 0.0 MET -0.033 0.142 -9999.0 0.0 -0.471 46.0 46.0 PLEKHA7 0.033 0.019 -9999.0 0.0 -9999.0 0.0 0.0 mol:GTP 0.005 0.083 -9999.0 0.0 -0.308 4.0 4.0 establishment of epithelial cell apical/basal polarity 0.054 0.014 -9999.0 0.0 -9999.0 0.0 0.0 cortical actin cytoskeleton stabilization 0.028 0.015 -9999.0 0.0 -0.211 2.0 2.0 regulation of cell-cell adhesion -0.006 0.102 -9999.0 0.0 -0.462 3.0 3.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin/EPLIN/cortical actin cytoskeleton 0.028 0.015 -9999.0 0.0 -0.212 2.0 2.0