Signaling events regulated by Ret tyrosine kinase Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations PTK2 -0.022 0.042 -9999.0 0.0 -9999.0 0.0 0.0 Crk/p130 Cas/Paxillin -0.062 0.106 -9999.0 0.0 -0.366 32.0 32.0 JUN -0.033 0.132 -9999.0 0.0 -0.413 31.0 31.0 HRAS 0.007 0.059 -9999.0 0.0 -0.576 5.0 5.0 RET51/GFRalpha1/GDNF/GRB10 -0.072 0.171 -9999.0 0.0 -0.361 99.0 99.0 RAP1A 0.013 0.0 -9999.0 0.0 -9999.0 0.0 0.0 FRS2 0.013 0.0 -9999.0 0.0 -9999.0 0.0 0.0 RAP1A/GDP 0.01 0.0 -9999.0 0.0 -9999.0 0.0 0.0 RET51/GFRalpha1/GDNF/DOK1 -0.072 0.171 -9999.0 0.0 -0.361 99.0 99.0 EntrezGene:5979 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 PTPN11 0.012 0.022 -9999.0 0.0 -0.471 1.0 1.0 mol:GTP -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 CRK 0.013 0.0 -9999.0 0.0 -9999.0 0.0 0.0 RET9/GFRalpha1/GDNF/Enigma -0.022 0.123 -9999.0 0.0 -0.301 70.0 70.0 RHOA 0.013 0.0 -9999.0 0.0 -9999.0 0.0 0.0 RAP1A/GTP -0.086 0.147 -9999.0 0.0 -0.447 34.0 34.0 GRB7 0.013 0.0 -9999.0 0.0 -9999.0 0.0 0.0 RET51/GFRalpha1/GDNF -0.072 0.171 -9999.0 0.0 -0.361 99.0 99.0 MAPKKK cascade -0.073 0.124 -9999.0 0.0 -0.451 26.0 26.0 BCAR1 0.013 0.0 -9999.0 0.0 -9999.0 0.0 0.0 RET9/GFRalpha1/GDNF/IRS1 -0.023 0.119 -9999.0 0.0 -0.29 74.0 74.0 lamellipodium assembly -0.058 0.1 -9999.0 0.0 -0.342 33.0 33.0 RET51/GFRalpha1/GDNF/SHC -0.072 0.171 -9999.0 0.0 -0.361 99.0 99.0 PIK3CA 0.01 0.038 -9999.0 0.0 -0.471 3.0 3.0 RET9/GFRalpha1/GDNF/SHC -0.015 0.103 -9999.0 0.0 -0.269 65.0 65.0 RET9/GFRalpha1/GDNF/Shank3 -0.015 0.103 -9999.0 0.0 -0.269 65.0 65.0 MAPK3 -0.054 0.153 -9999.0 0.0 -0.486 24.0 24.0 DOK1 0.013 0.0 -9999.0 0.0 -9999.0 0.0 0.0 DOK6 -0.024 0.136 -9999.0 0.0 -0.517 34.0 34.0 PXN 0.013 0.0 -9999.0 0.0 -9999.0 0.0 0.0 neurite development -0.046 0.152 -9999.0 0.0 -0.467 27.0 27.0 DOK5 -0.02 0.126 -9999.0 0.0 -0.501 31.0 31.0 GFRA1 -0.03 0.138 -9999.0 0.0 -0.473 43.0 43.0 MAPK8 -0.037 0.131 -9999.0 0.0 -0.424 29.0 29.0 HRAS/GTP -0.085 0.143 -9999.0 0.0 -0.515 26.0 26.0 tube development -0.008 0.097 -9999.0 0.0 -0.416 8.0 8.0 MAPK1 -0.054 0.153 -9999.0 0.0 -0.486 24.0 24.0 RET9/GFRalpha1/GDNF/FRS2/SHP2/Grb2 -0.007 0.093 -9999.0 0.0 -0.441 6.0 6.0 Rac1/GDP 0.01 0.0 -9999.0 0.0 -9999.0 0.0 0.0 SRC 0.013 0.0 -9999.0 0.0 -9999.0 0.0 0.0 PDLIM7 -0.001 0.084 -9999.0 0.0 -0.486 14.0 14.0 RET51/GFRalpha1/GDNF/Dok6 -0.08 0.184 -9999.0 0.0 -0.358 114.0 114.0 SHC1 0.013 0.0 -9999.0 0.0 -9999.0 0.0 0.0 RET51/GFRalpha1/GDNF/Dok4 -0.075 0.179 -9999.0 0.0 -0.374 100.0 100.0 RET51/GFRalpha1/GDNF/Dok5 -0.089 0.192 -9999.0 0.0 -0.393 109.0 109.0 PRKCA -0.007 0.096 -9999.0 0.0 -0.471 20.0 20.0 HRAS/GDP 0.005 0.044 -9999.0 0.0 -0.424 5.0 5.0 CREB1 -0.024 0.118 -9999.0 0.0 -0.414 22.0 22.0 PIK3R1 0.008 0.049 -9999.0 0.0 -0.471 5.0 5.0 RET9/GFRalpha1/GDNF/SHC/GAB1/Grb2 -0.007 0.095 -9999.0 0.0 -0.311 18.0 18.0 RET51/GFRalpha1/GDNF/Grb7 -0.072 0.171 -9999.0 0.0 -0.361 99.0 99.0 mol:GDP 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 RET -0.101 0.23 -9999.0 0.0 -0.564 96.0 96.0 DOK4 0.007 0.053 -9999.0 0.0 -0.471 6.0 6.0 JNK cascade -0.032 0.129 -9999.0 0.0 -0.404 31.0 31.0 RET9/GFRalpha1/GDNF/FRS2 -0.015 0.103 -9999.0 0.0 -0.269 65.0 65.0 SHANK3 0.013 0.0 -9999.0 0.0 -9999.0 0.0 0.0 RASA1 0.01 0.038 -9999.0 0.0 -0.471 3.0 3.0 NCK1 0.012 0.027 -9999.0 0.0 -0.576 1.0 1.0 RET9/GFRalpha1/GDNF/SHC/Grb2/SOS1 -0.007 0.093 -9999.0 0.0 -0.441 6.0 6.0 RET51/GFRalpha1/GDNF/FRS2/SHP2/Grb2 -0.04 0.128 -9999.0 0.0 -0.438 23.0 23.0 RET51/GFRalpha1/GDNF/DOK/RasGAP/NCK -0.041 0.131 -9999.0 0.0 -0.445 24.0 24.0 RET51/GFRalpha1/GDNF/SHC/Grb2/SOS1 -0.041 0.132 -9999.0 0.0 -0.469 23.0 23.0 PI3K -0.045 0.174 -9999.0 0.0 -0.531 33.0 33.0 SOS1 0.013 0.0 -9999.0 0.0 -9999.0 0.0 0.0 RET9/GFRalpha1/GDNF/Shank3/Grb2 -0.007 0.098 -9999.0 0.0 -0.416 8.0 8.0 GRB10 0.013 0.0 -9999.0 0.0 -9999.0 0.0 0.0 activation of MAPKK activity -0.036 0.126 -9999.0 0.0 -0.362 40.0 40.0 RET51/GFRalpha1/GDNF/FRS2 -0.072 0.171 -9999.0 0.0 -0.361 99.0 99.0 GAB1 0.012 0.022 -9999.0 0.0 -0.471 1.0 1.0 IRS1 -0.003 0.086 -9999.0 0.0 -0.471 16.0 16.0 IRS2 0.007 0.059 -9999.0 0.0 -0.576 5.0 5.0 RET51/GFRalpha1/GDNF/SHC/GAB1/Grb2 -0.041 0.136 -9999.0 0.0 -0.486 23.0 23.0 RET51/GFRalpha1/GDNF/PKC alpha -0.082 0.189 -9999.0 0.0 -0.391 103.0 103.0 GRB2 0.013 0.0 -9999.0 0.0 -9999.0 0.0 0.0 PRKACA 0.013 0.0 -9999.0 0.0 -9999.0 0.0 0.0 GDNF -0.017 0.113 -9999.0 0.0 -0.475 28.0 28.0 RAC1 0.013 0.0 -9999.0 0.0 -9999.0 0.0 0.0 RET51/GFRalpha1/GDNF/IRS1 -0.08 0.18 -9999.0 0.0 -0.374 104.0 104.0 Rac1/GTP -0.068 0.118 -9999.0 0.0 -0.411 33.0 33.0 RET9/GFRalpha1/GDNF -0.026 0.113 -9999.0 0.0 -0.304 65.0 65.0 GFRalpha1/GDNF -0.032 0.132 -9999.0 0.0 -0.359 65.0 65.0