S1P1 pathway Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations VEGFR2 homodimer/VEGFA homodimer -0.02 0.117 -9999.0 0.0 -0.364 48.0 48.0 PDGFRB 0.009 0.038 -9999.0 0.0 -0.579 2.0 2.0 SPHK1 -0.02 0.034 -9999.0 0.0 -9999.0 0.0 0.0 mol:S1P -0.024 0.039 -9999.0 0.0 -9999.0 0.0 0.0 S1P1/S1P/Gi -0.104 0.251 -9999.0 0.0 -0.489 120.0 120.0 GNAO1 -0.081 0.193 -9999.0 0.0 -0.477 93.0 93.0 PDGFB-D/PDGFRB/PLCgamma1 -0.081 0.22 -9999.0 0.0 -0.517 72.0 72.0 PLCG1 -0.091 0.234 -9999.0 0.0 -0.453 120.0 120.0 mol:GTP 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 PDGFB-D/PDGFRB 0.009 0.038 -9999.0 0.0 -0.578 2.0 2.0 GNAI2 0.012 0.006 -9999.0 0.0 -9999.0 0.0 0.0 GNAI3 0.011 0.006 -9999.0 0.0 -9999.0 0.0 0.0 GNAI1 0.003 0.065 -9999.0 0.0 -0.534 7.0 7.0 mol:GDP 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 EDG1 -0.018 0.099 -9999.0 0.0 -0.307 48.0 48.0 S1P1/S1P -0.024 0.105 -9999.0 0.0 -0.386 17.0 17.0 negative regulation of cAMP metabolic process -0.1 0.243 -9999.0 0.0 -0.474 120.0 120.0 MAPK3 -0.124 0.298 -9999.0 0.0 -0.6 120.0 120.0 calcium-dependent phospholipase C activity -0.002 0.003 -9999.0 0.0 -9999.0 0.0 0.0 Rac1/GDP 0.01 0.0 -9999.0 0.0 -9999.0 0.0 0.0 RhoA/GDP 0.01 0.0 -9999.0 0.0 -9999.0 0.0 0.0 KDR -0.009 0.099 -9999.0 0.0 -0.472 21.0 21.0 PLCB2 -0.016 0.098 -9999.0 0.0 -0.343 17.0 17.0 RAC1 0.013 0.0 -9999.0 0.0 -9999.0 0.0 0.0 RhoA/GTP -0.041 0.077 -9999.0 0.0 -0.327 17.0 17.0 receptor internalization -0.046 0.085 -9999.0 0.0 -0.362 17.0 17.0 PTGS2 -0.186 0.419 -9999.0 0.0 -0.993 96.0 96.0 Rac1/GTP -0.041 0.077 -9999.0 0.0 -0.327 17.0 17.0 RHOA 0.013 0.0 -9999.0 0.0 -9999.0 0.0 0.0 VEGFA -0.02 0.123 -9999.0 0.0 -0.49 31.0 31.0 negative regulation of T cell proliferation -0.1 0.243 -9999.0 0.0 -0.474 120.0 120.0 GO:0007205 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 GNAZ -0.035 0.143 -9999.0 0.0 -0.478 46.0 46.0 MAPK1 -0.124 0.298 -9999.0 0.0 -0.6 120.0 120.0 S1P1/S1P/PDGFB-D/PDGFRB -0.024 0.118 -9999.0 0.0 -0.408 19.0 19.0 ABCC1 0.012 0.003 -9999.0 0.0 -9999.0 0.0 0.0