S1P3 pathway Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations PDGFRB 0.011 0.038 -9999.0 0.0 -0.576 2.0 2.0 mol:S1P 0.001 0.001 -9999.0 0.0 -9999.0 0.0 0.0 S1P1/S1P/Gi -0.034 0.143 -9999.0 0.0 -0.405 47.0 47.0 GNAO1 -0.078 0.191 -9999.0 0.0 -0.47 93.0 93.0 S1P/S1P3/G12/G13 0.018 0.052 -9999.0 0.0 -0.247 15.0 15.0 AKT1 0.003 0.062 -9999.0 0.0 -9999.0 0.0 0.0 AKT3 -0.014 0.132 -9999.0 0.0 -0.854 4.0 4.0 mol:GTP -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 PDGFB-D/PDGFRB 0.011 0.038 -9999.0 0.0 -0.575 2.0 2.0 GNAI2 0.015 0.001 -9999.0 0.0 -9999.0 0.0 0.0 GNAI3 0.014 0.001 -9999.0 0.0 -9999.0 0.0 0.0 GNAI1 0.007 0.065 -9999.0 0.0 -0.532 7.0 7.0 mol:GDP 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 S1PR3 -0.003 0.093 -9999.0 0.0 -0.476 18.0 18.0 S1PR2 0.013 0.0 -9999.0 0.0 -9999.0 0.0 0.0 EDG1 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 mol:Ca2+ -0.037 0.169 -9999.0 0.0 -0.477 48.0 48.0 MAPK3 -0.029 0.161 -9999.0 0.0 -0.451 48.0 48.0 MAPK1 -0.029 0.161 -9999.0 0.0 -0.451 48.0 48.0 JAK2 -0.03 0.168 -9999.0 0.0 -0.458 50.0 50.0 CXCR4 -0.033 0.167 -9999.0 0.0 -0.442 54.0 54.0 FLT1 0.008 0.062 -9999.0 0.0 -0.5 7.0 7.0 RhoA/GDP 0.01 0.0 -9999.0 0.0 -9999.0 0.0 0.0 Rac1/GDP 0.01 0.0 -9999.0 0.0 -9999.0 0.0 0.0 SRC -0.029 0.161 -9999.0 0.0 -0.451 48.0 48.0 S1P/S1P3/Gi -0.037 0.17 -9999.0 0.0 -0.482 48.0 48.0 RAC1 0.013 0.0 -9999.0 0.0 -9999.0 0.0 0.0 RhoA/GTP -0.028 0.156 -9999.0 0.0 -0.437 48.0 48.0 VEGFA -0.016 0.123 -9999.0 0.0 -0.487 31.0 31.0 S1P/S1P2/Gi -0.029 0.144 -9999.0 0.0 -0.423 41.0 41.0 VEGFR1 homodimer/VEGFA homodimer -0.001 0.105 -9999.0 0.0 -0.368 35.0 35.0 RHOA 0.013 0.0 -9999.0 0.0 -9999.0 0.0 0.0 S1P/S1P3/Gq -0.001 0.104 -9999.0 0.0 -0.548 10.0 10.0 GNAQ 0.013 0.0 -9999.0 0.0 -9999.0 0.0 0.0 GNAZ -0.031 0.142 -9999.0 0.0 -0.47 46.0 46.0 G12/G13 0.02 0.0 -9999.0 0.0 -9999.0 0.0 0.0 GNA14 0.012 0.022 -9999.0 0.0 -0.471 1.0 1.0 GNA15 -0.011 0.105 -9999.0 0.0 -0.471 24.0 24.0 GNA12 0.013 0.0 -9999.0 0.0 -9999.0 0.0 0.0 GNA13 0.013 0.0 -9999.0 0.0 -9999.0 0.0 0.0 GNA11 -0.003 0.086 -9999.0 0.0 -0.471 16.0 16.0 Rac1/GTP -0.028 0.156 -9999.0 0.0 -0.437 48.0 48.0