IL6-mediated signaling events Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations BCL2L1 -0.058 0.22 -9999.0 0.0 -0.68 19.0 19.0 CRP -0.077 0.243 -9999.0 0.0 -0.706 28.0 28.0 cell cycle arrest -0.075 0.248 -9999.0 0.0 -0.673 39.0 39.0 TIMP1 -0.052 0.219 -9999.0 0.0 -0.742 17.0 17.0 IL6ST -0.085 0.197 -9999.0 0.0 -0.472 100.0 100.0 Rac1/GDP -0.107 0.229 -9999.0 0.0 -0.485 100.0 100.0 AP1 -0.017 0.136 -9999.0 0.0 -0.505 10.0 10.0 GAB2 0.014 0.002 -9999.0 0.0 -9999.0 0.0 0.0 TNFSF11 -0.068 0.24 -9999.0 0.0 -0.779 22.0 22.0 HSP90B1 0.018 0.044 -9999.0 0.0 -9999.0 0.0 0.0 GAB1 0.013 0.022 -9999.0 0.0 -0.47 1.0 1.0 MAPK14 -0.149 0.3 -9999.0 0.0 -0.643 107.0 107.0 AKT1 0.044 0.057 -9999.0 0.0 -1.022 1.0 1.0 FOXO1 0.049 0.053 -9999.0 0.0 -0.944 1.0 1.0 MAP2K6 -0.14 0.268 -9999.0 0.0 -0.562 112.0 112.0 mol:GTP 0.0 0.001 -9999.0 0.0 -9999.0 0.0 0.0 MAP2K4 -0.087 0.231 -9999.0 0.0 -0.523 75.0 75.0 MITF -0.114 0.23 -9999.0 0.0 -0.474 111.0 111.0 positive regulation of NF-kappaB transcription factor activity -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 TYK2 0.013 0.0 -9999.0 0.0 -9999.0 0.0 0.0 A2M 0.016 0.05 -9999.0 0.0 -9999.0 0.0 0.0 CEBPB 0.02 0.002 -9999.0 0.0 -9999.0 0.0 0.0 GRB2/SOS1/GAB family/SHP2 -0.016 0.086 -9999.0 0.0 -0.407 2.0 2.0 STAT3 -0.076 0.261 -9999.0 0.0 -0.712 39.0 39.0 STAT1 -0.009 0.026 -9999.0 0.0 -9999.0 0.0 0.0 CEBPD -0.063 0.232 -9999.0 0.0 -0.726 23.0 23.0 PIK3CA 0.012 0.038 -9999.0 0.0 -0.47 3.0 3.0 PI3K 0.017 0.048 -9999.0 0.0 -0.368 7.0 7.0 JUN 0.006 0.062 -9999.0 0.0 -0.501 7.0 7.0 PIAS3/MITF -0.102 0.219 -9999.0 0.0 -0.457 104.0 104.0 MAPK11 -0.155 0.309 -9999.0 0.0 -0.653 110.0 110.0 STAT3 (dimer)/FOXO1 -0.014 0.204 -9999.0 0.0 -0.57 15.0 15.0 GRB2/SOS1/GAB family -0.11 0.166 -9999.0 0.0 -0.47 57.0 57.0 IL6/IL6RA/gp130 (dimer)/JAK1/JAK1/LMO4/HCK -0.116 0.218 -9999.0 0.0 -0.451 112.0 112.0 GRB2 0.014 0.001 -9999.0 0.0 -9999.0 0.0 0.0 JAK2 0.012 0.022 -9999.0 0.0 -0.471 1.0 1.0 LBP -0.053 0.205 -9999.0 0.0 -0.642 15.0 15.0 PIK3R1 0.009 0.049 -9999.0 0.0 -0.47 5.0 5.0 JAK1 0.013 0.006 -9999.0 0.0 -9999.0 0.0 0.0 MYC -0.073 0.238 -9999.0 0.0 -0.727 21.0 21.0 FGG -0.072 0.231 -9999.0 0.0 -0.69 26.0 26.0 macrophage differentiation -0.075 0.248 -9999.0 0.0 -0.673 39.0 39.0 IL6/IL6RA/gp130 (dimer)/JAK2/JAK2/LMO4 -0.121 0.208 -9999.0 0.0 -0.455 92.0 92.0 JUNB -0.074 0.257 -9999.0 0.0 -0.816 30.0 30.0 FOS -0.076 0.189 -9999.0 0.0 -0.477 88.0 88.0 IL6/IL6RA/gp130 (dimer)/JAK1/JAK1/LMO4 -0.126 0.238 -9999.0 0.0 -0.49 116.0 116.0 STAT1/PIAS1 -0.093 0.202 -9999.0 0.0 -0.462 78.0 78.0 GRB2/SOS1/GAB family/SHP2/PI3K 0.034 0.06 -9999.0 0.0 -1.101 1.0 1.0 STAT3 (dimer) -0.073 0.259 -9999.0 0.0 -0.705 39.0 39.0 PRKCD -0.071 0.236 -9999.0 0.0 -0.572 52.0 52.0 IL6R -0.022 0.127 -9999.0 0.0 -0.471 36.0 36.0 SOCS3 -0.199 0.415 -9999.0 0.0 -1.027 82.0 82.0 gp130 (dimer)/JAK1/JAK1/LMO4 -0.032 0.126 -9999.0 0.0 -0.286 61.0 61.0 Rac1/GTP -0.104 0.232 -9999.0 0.0 -0.521 84.0 84.0 HCK 0.009 0.046 -9999.0 0.0 -0.497 4.0 4.0 MAPKKK cascade 0.009 0.074 -9999.0 0.0 -0.849 1.0 1.0 bone resorption -0.064 0.23 -9999.0 0.0 -0.72 23.0 23.0 IRF1 -0.063 0.231 -9999.0 0.0 -0.741 20.0 20.0 mol:GDP -0.12 0.237 -9999.0 0.0 -0.489 114.0 114.0 SOS1 0.014 0.002 -9999.0 0.0 -9999.0 0.0 0.0 VAV1 -0.122 0.241 -9999.0 0.0 -0.497 114.0 114.0 IL6/IL6RA/gp130 (dimer)/JAK1/JAK1/LMO4/SOCS3 -0.163 0.309 -9999.0 0.0 -0.666 110.0 110.0 PTPN11 -0.008 0.047 -9999.0 0.0 -0.998 1.0 1.0 IL6/IL6RA -0.124 0.202 -9999.0 0.0 -0.379 180.0 180.0 gp130 (dimer)/TYK2/TYK2/LMO4 -0.034 0.123 -9999.0 0.0 -0.279 63.0 63.0 gp130 (dimer)/JAK2/JAK2/LMO4 -0.034 0.125 -9999.0 0.0 -0.292 44.0 44.0 IL6 -0.152 0.248 -9999.0 0.0 -0.512 155.0 155.0 PIAS3 0.013 0.0 -9999.0 0.0 -9999.0 0.0 0.0 PTPRE 0.007 0.042 -9999.0 0.0 -0.502 3.0 3.0 PIAS1 0.012 0.022 -9999.0 0.0 -0.471 1.0 1.0 RAC1 0.014 0.001 -9999.0 0.0 -9999.0 0.0 0.0 IL6/IL6RA/gp130 (dimer)/TYK2/TYK2/LMO4 -0.124 0.208 -9999.0 0.0 -0.429 118.0 118.0 LMO4 0.014 0.026 -9999.0 0.0 -0.509 1.0 1.0 STAT3 (dimer)/PIAS3 -0.078 0.249 -9999.0 0.0 -0.678 37.0 37.0 MCL1 0.049 0.049 -9999.0 0.0 -0.847 1.0 1.0