Neurotrophic factor-mediated Trk receptor signaling Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations CRKL 0.027 0.005 -9999.0 0.0 -9999.0 0.0 0.0 RAS family/GTP/Tiam1 -0.013 0.074 -9999.0 0.0 -0.209 39.0 39.0 NT3 (dimer)/TRKC -0.027 0.129 -9999.0 0.0 -0.263 103.0 103.0 NT3 (dimer)/TRKB -0.011 0.123 -9999.0 0.0 -0.227 104.0 104.0 SHC/Grb2/SOS1/GAB1/PI3K 0.019 0.029 -9999.0 0.0 -0.204 6.0 6.0 RAPGEF1 0.026 0.006 -9999.0 0.0 -9999.0 0.0 0.0 BDNF -0.039 0.133 -9999.0 0.0 -0.308 95.0 95.0 PIK3CA 0.023 0.027 -9999.0 0.0 -0.308 3.0 3.0 DYNLT1 0.027 0.004 -9999.0 0.0 -9999.0 0.0 0.0 NTRK1 0.009 0.081 0.166 8.0 -0.308 28.0 36.0 NTRK2 -0.015 0.11 0.166 1.0 -0.308 59.0 60.0 NTRK3 -0.037 0.132 -9999.0 0.0 -0.308 92.0 92.0 NT-4/5 (dimer)/TRKB -0.035 0.142 -9999.0 0.0 -0.238 143.0 143.0 neuron apoptosis 0.052 0.161 0.38 69.0 -0.226 1.0 70.0 SHC 2-3/Grb2 -0.057 0.175 0.235 1.0 -0.414 69.0 70.0 SHC1 0.026 0.006 -9999.0 0.0 -9999.0 0.0 0.0 SHC2 -0.05 0.147 -9999.0 0.0 -0.409 51.0 51.0 SHC3 -0.075 0.191 0.249 1.0 -0.473 72.0 73.0 STAT3 (dimer) 0.031 0.007 -9999.0 0.0 -9999.0 0.0 0.0 NT3 (dimer)/TRKA 0.004 0.109 -9999.0 0.0 -0.216 83.0 83.0 RIN/GDP 0.006 0.094 0.269 15.0 -0.223 21.0 36.0 GIPC1 0.027 0.003 -9999.0 0.0 -9999.0 0.0 0.0 KRAS 0.025 0.007 -9999.0 0.0 -9999.0 0.0 0.0 DNAJA3 -0.029 0.094 -9999.0 0.0 -0.245 64.0 64.0 RIN/GTP 0.022 0.027 0.118 31.0 -0.108 2.0 33.0 CCND1 0.015 0.005 -9999.0 0.0 -9999.0 0.0 0.0 MAGED1 0.028 0.007 0.166 1.0 -9999.0 0.0 1.0 PTPN11 0.025 0.016 -9999.0 0.0 -0.308 1.0 1.0 RICS 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 NT-4/5 (dimer) -0.048 0.139 -9999.0 0.0 -0.307 108.0 108.0 SHC/GRB2/SOS1 0.049 0.018 -9999.0 0.0 -9999.0 0.0 0.0 GRB2 0.026 0.005 -9999.0 0.0 -9999.0 0.0 0.0 NGF (dimer)/TRKA/MATK 0.058 0.101 0.234 1.0 -0.2 50.0 51.0 TRKA/NEDD4-2 0.022 0.062 0.138 14.0 -0.213 27.0 41.0 ELMO1 0.024 0.017 -9999.0 0.0 -0.308 1.0 1.0 RhoG/GTP/ELMO1/DOCK1 0.03 0.021 -9999.0 0.0 -0.177 3.0 3.0 NGF 0.013 0.068 0.166 2.0 -0.308 20.0 22.0 HRAS 0.028 0.015 0.166 5.0 -9999.0 0.0 5.0 DOCK1 0.024 0.027 -9999.0 0.0 -0.308 3.0 3.0 GAB2 0.026 0.006 -9999.0 0.0 -9999.0 0.0 0.0 RIT2 0.031 0.036 0.166 31.0 -9999.0 0.0 31.0 RIT1 0.026 0.006 -9999.0 0.0 -9999.0 0.0 0.0 FRS2 0.026 0.006 -9999.0 0.0 -9999.0 0.0 0.0 DNM1 0.025 0.018 0.166 1.0 -0.308 1.0 2.0 mol:GTP 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 CRK 0.025 0.007 -9999.0 0.0 -9999.0 0.0 0.0 SH2B1 (homopentamer) -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 RhoG/GTP -0.012 0.099 -9999.0 0.0 -0.236 66.0 66.0 mol:GDP -0.01 0.121 0.311 15.0 -0.316 25.0 40.0 NGF (dimer) 0.013 0.067 0.166 2.0 -0.307 20.0 22.0 RhoG/GDP 0.018 0.012 -9999.0 0.0 -0.209 1.0 1.0 RIT1/GDP 0.0 0.088 0.266 11.0 -0.223 21.0 32.0 TIAM1 0.024 0.027 -9999.0 0.0 -0.308 3.0 3.0 PIK3R1 0.023 0.027 -9999.0 0.0 -0.308 3.0 3.0 BDNF (dimer)/TRKB -0.015 0.127 -9999.0 0.0 -0.238 109.0 109.0 KIDINS220/CRKL/C3G 0.037 0.011 -9999.0 0.0 -9999.0 0.0 0.0 SHC/RasGAP 0.035 0.021 -9999.0 0.0 -0.214 2.0 2.0 FRS2 family/SHP2 0.051 0.018 -9999.0 0.0 -0.181 1.0 1.0 SHC/GRB2/SOS1/GAB1 0.062 0.025 -9999.0 0.0 -0.166 1.0 1.0 RIT1/GTP 0.019 0.004 -9999.0 0.0 -9999.0 0.0 0.0 NT3 (dimer) -0.006 0.097 -9999.0 0.0 -0.307 45.0 45.0 RAP1/GDP -0.004 0.068 0.142 3.0 -0.194 20.0 23.0 KIDINS220/CRKL 0.027 0.005 -9999.0 0.0 -9999.0 0.0 0.0 BDNF (dimer) -0.039 0.133 -9999.0 0.0 -0.307 95.0 95.0 ubiquitin-dependent protein catabolic process 0.025 0.074 -9999.0 0.0 -0.186 45.0 45.0 Schwann cell development -0.022 0.026 -9999.0 0.0 -0.096 12.0 12.0 EHD4 0.027 0.005 -9999.0 0.0 -9999.0 0.0 0.0 FRS2 family/GRB2/SOS1 0.063 0.023 -9999.0 0.0 -9999.0 0.0 0.0 FRS2 family/SHP2/CRK family/C3G/GAB2 0.024 0.029 -9999.0 0.0 -0.17 2.0 2.0 RAP1B 0.026 0.006 -9999.0 0.0 -9999.0 0.0 0.0 RAP1A 0.027 0.005 -9999.0 0.0 -9999.0 0.0 0.0 CDC42/GTP -0.044 0.143 -9999.0 0.0 -0.243 137.0 137.0 ABL1 0.026 0.006 -9999.0 0.0 -9999.0 0.0 0.0 SH2B family/GRB2/SOS1 0.038 0.011 -9999.0 0.0 -9999.0 0.0 0.0 Rap1/GTP -0.004 0.084 -9999.0 0.0 -0.324 18.0 18.0 STAT3 0.031 0.007 -9999.0 0.0 -9999.0 0.0 0.0 axon guidance -0.05 0.134 -9999.0 0.0 -0.234 137.0 137.0 MAPK3 -0.04 0.06 0.182 10.0 -0.196 39.0 49.0 MAPK1 -0.041 0.062 0.181 11.0 -0.195 41.0 52.0 CDC42/GDP 0.003 0.092 0.253 15.0 -0.224 20.0 35.0 NTF3 -0.006 0.097 -9999.0 0.0 -0.308 45.0 45.0 NTF4 -0.048 0.139 -9999.0 0.0 -0.308 108.0 108.0 NGF (dimer)/TRKA/FAIM 0.028 0.072 -9999.0 0.0 -0.185 44.0 44.0 PI3K 0.032 0.033 -9999.0 0.0 -0.249 5.0 5.0 FRS3 0.027 0.003 -9999.0 0.0 -9999.0 0.0 0.0 FAIM 0.025 0.007 -9999.0 0.0 -9999.0 0.0 0.0 GAB1 0.026 0.016 -9999.0 0.0 -0.308 1.0 1.0 RASGRF1 -0.049 0.118 -9999.0 0.0 -0.294 70.0 70.0 SOS1 0.026 0.005 -9999.0 0.0 -9999.0 0.0 0.0 MCF2L -0.054 0.09 -9999.0 0.0 -0.225 94.0 94.0 RGS19 0.027 0.008 0.166 1.0 -9999.0 0.0 1.0 CDC42 0.027 0.004 -9999.0 0.0 -9999.0 0.0 0.0 RAS family/GTP -0.0 0.107 0.286 5.0 -0.427 14.0 19.0 Rac1/GDP 0.0 0.083 0.261 7.0 -0.218 21.0 28.0 NGF (dimer)/TRKA/GRIT 0.015 0.067 0.125 10.0 -0.181 47.0 57.0 neuron projection morphogenesis -0.034 0.177 -9999.0 0.0 -0.8 16.0 16.0 NGF (dimer)/TRKA/NEDD4-2 0.026 0.075 -9999.0 0.0 -0.186 45.0 45.0 MAP2K1 -0.001 0.07 0.227 35.0 -9999.0 0.0 35.0 NGFR -0.001 0.092 -9999.0 0.0 -0.308 40.0 40.0 NGF (dimer)/TRKA/GIPC/GAIP 0.006 0.061 -9999.0 0.0 -0.184 41.0 41.0 RAS family/GTP/PI3K 0.016 0.026 -9999.0 0.0 -0.21 5.0 5.0 FRS2 family/SHP2/GRB2/SOS1 0.071 0.03 -9999.0 0.0 -0.159 1.0 1.0 NRAS 0.026 0.016 -9999.0 0.0 -0.308 1.0 1.0 GRB2/SOS1 0.038 0.011 -9999.0 0.0 -9999.0 0.0 0.0 PRKCI 0.025 0.01 0.166 1.0 -9999.0 0.0 1.0 ChemicalAbstracts:146-91-8 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 RAC1 0.025 0.008 -9999.0 0.0 -9999.0 0.0 0.0 PRKCZ 0.027 0.004 -9999.0 0.0 -9999.0 0.0 0.0 MAPKKK cascade -0.063 0.209 -9999.0 0.0 -0.544 71.0 71.0 RASA1 0.024 0.022 -9999.0 0.0 -0.308 2.0 2.0 TRKA/c-Abl 0.025 0.059 0.139 8.0 -0.21 26.0 34.0 SQSTM1 0.027 0.004 -9999.0 0.0 -9999.0 0.0 0.0 BDNF (dimer)/TRKB/GIPC 0.0 0.123 -9999.0 0.0 -0.215 110.0 110.0 NGF (dimer)/TRKA/p62/Atypical PKCs 0.047 0.074 -9999.0 0.0 -0.164 42.0 42.0 MATK 0.085 0.074 0.166 209.0 -0.308 2.0 211.0 NEDD4L 0.027 0.025 0.166 13.0 -9999.0 0.0 13.0 RAS family/GDP -0.021 0.052 -9999.0 0.0 -0.158 32.0 32.0 NGF (dimer)/TRKA -0.027 0.101 -9999.0 0.0 -0.25 71.0 71.0 Rac1/GTP -0.04 0.091 -9999.0 0.0 -0.22 74.0 74.0 FRS2 family/SHP2/CRK family 0.07 0.031 -9999.0 0.0 -0.159 1.0 1.0