Ceramide signaling pathway Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations SPHK2 -0.011 0.004 -9999.0 0.0 -9999.0 0.0 0.0 MAP4K4 0.0 0.052 -9999.0 0.0 -0.289 4.0 4.0 BAG4 0.008 0.063 -9999.0 0.0 -0.308 18.0 18.0 PKC zeta/ceramide 0.003 0.07 -9999.0 0.0 -0.197 40.0 40.0 NFKBIA 0.027 0.004 -9999.0 0.0 -9999.0 0.0 0.0 BIRC3 0.026 0.02 0.166 3.0 -0.308 1.0 4.0 BAX -0.001 0.06 -9999.0 0.0 -0.341 12.0 12.0 RIPK1 0.027 0.005 -9999.0 0.0 -9999.0 0.0 0.0 AKT1 0.006 0.106 0.726 10.0 -9999.0 0.0 10.0 BAD -0.011 0.071 0.198 10.0 -0.208 35.0 45.0 SMPD1 0.015 0.062 0.208 20.0 -0.154 5.0 25.0 RB1 -0.016 0.063 -9999.0 0.0 -0.19 40.0 40.0 FADD/Caspase 8 0.006 0.055 0.212 5.0 -0.296 4.0 9.0 MAP2K4 -0.017 0.061 0.177 1.0 -0.2 32.0 33.0 NSMAF 0.023 0.01 -9999.0 0.0 -9999.0 0.0 0.0 response to UV 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 RAF1 -0.019 0.071 0.171 8.0 -0.207 38.0 46.0 EGF 0.023 0.08 0.166 38.0 -0.308 21.0 59.0 mol:ceramide -0.014 0.069 -9999.0 0.0 -0.206 41.0 41.0 MADD 0.026 0.005 -9999.0 0.0 -9999.0 0.0 0.0 response to oxidative stress -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 mol:Free Fatty acid -0.008 0.006 -9999.0 0.0 -9999.0 0.0 0.0 ASAH1 0.019 0.012 -9999.0 0.0 -9999.0 0.0 0.0 negative regulation of cell cycle -0.016 0.062 -9999.0 0.0 -0.188 40.0 40.0 cell proliferation -0.0 0.078 0.202 2.0 -0.216 27.0 29.0 BID 0.005 0.109 -9999.0 0.0 -0.633 11.0 11.0 MAP3K1 -0.016 0.064 0.192 1.0 -0.195 39.0 40.0 EIF2A -0.007 0.071 0.185 25.0 -0.195 29.0 54.0 TRADD 0.024 0.009 -9999.0 0.0 -9999.0 0.0 0.0 CRADD 0.026 0.006 -9999.0 0.0 -9999.0 0.0 0.0 MAPK3 -0.017 0.069 0.178 8.0 -0.223 25.0 33.0 response to heat -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 MAPK1 -0.018 0.071 0.178 8.0 -0.212 30.0 38.0 Cathepsin D/ceramide 0.004 0.069 -9999.0 0.0 -0.203 37.0 37.0 FADD 0.002 0.055 0.201 5.0 -0.289 4.0 9.0 KSR1 -0.021 0.073 0.192 1.0 -0.2 51.0 52.0 MAPK8 -0.012 0.074 -9999.0 0.0 -0.227 29.0 29.0 PRKRA -0.016 0.062 0.189 1.0 -0.196 38.0 39.0 PDGFA 0.025 0.008 -9999.0 0.0 -9999.0 0.0 0.0 TRAF2 0.026 0.006 -9999.0 0.0 -9999.0 0.0 0.0 IGF1 0.009 0.088 0.166 17.0 -0.308 32.0 49.0 mol:GD3 -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ganglioside biosynthetic process -0.014 0.069 -9999.0 0.0 -0.205 41.0 41.0 CTSD 0.027 0.004 -9999.0 0.0 -9999.0 0.0 0.0 regulation of nitric oxide biosynthetic process 0.038 0.01 -9999.0 0.0 -9999.0 0.0 0.0 response to radiation -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ERK1/PKC delta 0.0 0.084 0.216 2.0 -0.233 26.0 28.0 PRKCD 0.026 0.005 -9999.0 0.0 -9999.0 0.0 0.0 PRKCZ 0.027 0.004 -9999.0 0.0 -9999.0 0.0 0.0 mol:GW4869 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 mol:sphingosine -0.008 0.006 -9999.0 0.0 -9999.0 0.0 0.0 RelA/NF kappa B1 0.038 0.01 -9999.0 0.0 -9999.0 0.0 0.0 mol:glutathione 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 PAWR 0.026 0.005 -9999.0 0.0 -9999.0 0.0 0.0 TNF-alpha/TNFR1A/TRADD/MADD/cIAP2/RIP1/TRAF2/RAIDD 0.008 0.048 -9999.0 0.0 -0.301 4.0 4.0 TNFR1A/BAG4/TNF-alpha 0.021 0.07 -9999.0 0.0 -0.178 44.0 44.0 mol:Sphingosine-1-phosphate -0.011 0.004 -9999.0 0.0 -9999.0 0.0 0.0 MAP2K1 -0.021 0.068 0.174 8.0 -0.214 30.0 38.0 mol:C11AG 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 RELA 0.026 0.006 -9999.0 0.0 -9999.0 0.0 0.0 CYCS 0.015 0.055 0.14 20.0 -0.213 10.0 30.0 TNFRSF1A 0.025 0.007 -9999.0 0.0 -9999.0 0.0 0.0 NFKB1 0.027 0.004 -9999.0 0.0 -9999.0 0.0 0.0 TNFR1A/BAG4 0.02 0.049 -9999.0 0.0 -0.214 18.0 18.0 EIF2AK2 -0.017 0.059 0.188 2.0 -0.194 35.0 37.0 TNF-alpha/TNFR1A/FAN 0.033 0.057 -9999.0 0.0 -0.177 26.0 26.0 response to hydrogen peroxide 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 CASP8 0.02 0.037 -9999.0 0.0 -9999.0 0.0 0.0 MAP2K2 -0.021 0.069 0.19 7.0 -0.212 32.0 39.0 SMPD3 -0.003 0.084 0.201 4.0 -0.293 26.0 30.0 TNF 0.011 0.081 0.166 11.0 -0.308 27.0 38.0 PKC zeta/PAR4 0.038 0.009 -9999.0 0.0 -9999.0 0.0 0.0 mol:PHOSPHOCHOLINE -0.006 0.061 0.174 19.0 -0.164 29.0 48.0 NF kappa B1/RelA/I kappa B alpha 0.072 0.026 -9999.0 0.0 -9999.0 0.0 0.0 AIFM1 0.008 0.061 0.141 14.0 -0.208 11.0 25.0 BCL2 0.015 0.055 -9999.0 0.0 -0.308 13.0 13.0