E-cadherin signaling in the nascent adherens junction Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations CTTN -0.009 0.086 -9999.0 0.0 -0.256 51.0 51.0 KLHL20 0.015 0.043 0.161 3.0 -0.19 1.0 4.0 CYFIP2 0.027 0.005 -9999.0 0.0 -9999.0 0.0 0.0 Rac1/GDP 0.016 0.062 0.339 6.0 -9999.0 0.0 6.0 ENAH -0.009 0.085 -9999.0 0.0 -0.256 49.0 49.0 AP1M1 0.027 0.003 -9999.0 0.0 -9999.0 0.0 0.0 RAP1B 0.026 0.006 -9999.0 0.0 -9999.0 0.0 0.0 RAP1A 0.027 0.005 -9999.0 0.0 -9999.0 0.0 0.0 CTNNB1 0.027 0.005 -9999.0 0.0 -9999.0 0.0 0.0 CDC42/GTP 0.019 0.026 -9999.0 0.0 -9999.0 0.0 0.0 ABI1/Sra1/Nap1 -0.005 0.021 -9999.0 0.0 -0.134 1.0 1.0 E-cadherin/beta catenin/alpha catenin/beta7/alphaE Integrin 0.049 0.048 -9999.0 0.0 -0.154 16.0 16.0 RAPGEF1 -0.008 0.078 0.293 4.0 -0.228 43.0 47.0 CTNND1 0.027 0.004 -9999.0 0.0 -9999.0 0.0 0.0 regulation of calcium-dependent cell-cell adhesion -0.002 0.092 -9999.0 0.0 -0.26 54.0 54.0 CRK -0.007 0.076 -9999.0 0.0 -0.246 41.0 41.0 E-cadherin/gamma catenin/alpha catenin 0.046 0.021 -9999.0 0.0 -9999.0 0.0 0.0 alphaE/beta7 Integrin 0.029 0.048 0.139 3.0 -0.208 17.0 20.0 IQGAP1 0.027 0.003 -9999.0 0.0 -9999.0 0.0 0.0 NCKAP1 0.026 0.005 -9999.0 0.0 -9999.0 0.0 0.0 Rap1/GTP/I-afadin 0.047 0.016 -9999.0 0.0 -9999.0 0.0 0.0 DLG1 -0.008 0.084 -9999.0 0.0 -0.256 48.0 48.0 ChemicalAbstracts:7440-70-2 -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 mol:PI-3-4-5-P3 -0.015 0.014 -9999.0 0.0 -0.134 2.0 2.0 MLLT4 0.026 0.005 -9999.0 0.0 -9999.0 0.0 0.0 ARF6/GTP/NME1/Tiam1 0.05 0.024 -9999.0 0.0 -0.162 2.0 2.0 PI3K -0.018 0.018 -9999.0 0.0 -0.17 2.0 2.0 ARF6 0.027 0.004 -9999.0 0.0 -9999.0 0.0 0.0 mol:Ca2+ 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/gamma catenin 0.035 0.014 -9999.0 0.0 -9999.0 0.0 0.0 TIAM1 0.024 0.027 -9999.0 0.0 -0.308 3.0 3.0 E-cadherin(dimer)/Ca2+ 0.053 0.026 -9999.0 0.0 -9999.0 0.0 0.0 AKT1 -0.007 0.027 0.105 5.0 -0.122 1.0 6.0 PIK3R1 0.023 0.027 -9999.0 0.0 -0.308 3.0 3.0 CDH1 0.024 0.009 -9999.0 0.0 -9999.0 0.0 0.0 RhoA/GDP 0.019 0.069 0.313 11.0 -9999.0 0.0 11.0 actin cytoskeleton organization 0.016 0.043 0.197 11.0 -0.14 1.0 12.0 CDC42/GDP 0.021 0.072 0.286 16.0 -9999.0 0.0 16.0 E-cadherin/Ca2+/gamma catenin/alpha catenin/p120 catenin 0.016 0.007 -9999.0 0.0 -9999.0 0.0 0.0 ITGB7 0.016 0.063 0.166 3.0 -0.308 17.0 20.0 RAC1 0.025 0.008 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/beta catenin/alpha catenin/p120 catenin 0.057 0.028 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/Ca2+/beta catenin/alpha catenin 0.04 0.019 -9999.0 0.0 -9999.0 0.0 0.0 mol:GDP 0.008 0.076 0.3 16.0 -9999.0 0.0 16.0 CDC42/GTP/IQGAP1 0.036 0.006 -9999.0 0.0 -9999.0 0.0 0.0 JUP 0.027 0.004 -9999.0 0.0 -9999.0 0.0 0.0 p120 catenin/RhoA/GDP 0.022 0.061 0.378 3.0 -9999.0 0.0 3.0 RAC1/GTP/IQGAP1 0.033 0.011 -9999.0 0.0 -9999.0 0.0 0.0 PIP5K1C/AP1M1 0.039 0.008 -9999.0 0.0 -9999.0 0.0 0.0 RHOA 0.027 0.005 -9999.0 0.0 -9999.0 0.0 0.0 CDC42 0.027 0.004 -9999.0 0.0 -9999.0 0.0 0.0 CTNNA1 0.026 0.006 -9999.0 0.0 -9999.0 0.0 0.0 positive regulation of S phase of mitotic cell cycle 0.015 0.037 0.182 11.0 -0.091 1.0 12.0 NME1 0.03 0.021 0.166 11.0 -9999.0 0.0 11.0 clathrin coat assembly -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 TJP1 -0.007 0.084 -9999.0 0.0 -0.256 47.0 47.0 regulation of cell-cell adhesion 0.012 0.02 -9999.0 0.0 -9999.0 0.0 0.0 WASF2 0.006 0.02 0.08 3.0 -9999.0 0.0 3.0 Rap1/GTP 0.021 0.036 0.19 10.0 -9999.0 0.0 10.0 E-cadherin/gamma catenin/alpha catenin/beta7/alphaE Integrin 0.057 0.051 -9999.0 0.0 -0.147 15.0 15.0 CCND1 0.017 0.042 0.216 10.0 -0.109 1.0 11.0 VAV2 0.008 0.088 0.327 1.0 -0.549 1.0 2.0 RAP1/GDP 0.027 0.051 0.251 10.0 -9999.0 0.0 10.0 adherens junction assembly -0.007 0.082 -9999.0 0.0 -0.25 47.0 47.0 homophilic cell adhesion 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ABI1 0.027 0.004 -9999.0 0.0 -9999.0 0.0 0.0 PIP5K1C 0.027 0.005 -9999.0 0.0 -9999.0 0.0 0.0 regulation of heterotypic cell-cell adhesion 0.042 0.045 0.184 6.0 -0.146 14.0 20.0 E-cadherin/beta catenin 0.011 0.007 -9999.0 0.0 -9999.0 0.0 0.0 mol:GTP 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 SRC -0.009 0.086 -9999.0 0.0 -0.256 51.0 51.0 PIK3CA 0.023 0.027 -9999.0 0.0 -0.308 3.0 3.0 Rac1/GTP 0.002 0.045 -9999.0 0.0 -0.294 1.0 1.0 E-cadherin/beta catenin/alpha catenin 0.045 0.022 -9999.0 0.0 -9999.0 0.0 0.0 ITGAE 0.025 0.007 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin -0.003 0.094 -9999.0 0.0 -0.264 54.0 54.0