Nephrin/Neph1 signaling in the kidney podocyte Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations positive regulation of NF-kappaB transcription factor activity 0.009 0.106 0.225 90.0 -0.151 10.0 100.0 KIRREL -0.036 0.134 -9999.0 0.0 -0.315 90.0 90.0 Nephrin/NEPH1Par3/Par6/Atypical PKCs -0.009 0.106 0.151 10.0 -0.225 90.0 100.0 PLCG1 0.027 0.005 -9999.0 0.0 -9999.0 0.0 0.0 ARRB2 0.025 0.007 -9999.0 0.0 -9999.0 0.0 0.0 WASL 0.025 0.008 -9999.0 0.0 -9999.0 0.0 0.0 Nephrin/NEPH1/podocin/CD2AP 0.021 0.095 0.222 1.0 -0.168 89.0 90.0 ChemicalAbstracts:57-88-5 -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 Nephrin/NEPH1/podocin/NCK1-2/N-WASP -0.015 0.078 -9999.0 0.0 -0.187 79.0 79.0 FYN -0.029 0.068 0.215 12.0 -0.165 72.0 84.0 mol:Ca2+ 0.02 0.093 0.214 1.0 -0.166 88.0 89.0 mol:DAG 0.021 0.094 0.218 1.0 -0.166 88.0 89.0 NPHS2 -0.003 0.033 0.174 3.0 -9999.0 0.0 3.0 mol:IP3 0.021 0.094 0.218 1.0 -0.166 88.0 89.0 regulation of endocytosis 0.007 0.08 -9999.0 0.0 -0.151 89.0 89.0 Nephrin/NEPH1/podocin/Cholesterol 0.01 0.087 0.204 1.0 -0.163 90.0 91.0 establishment of cell polarity -0.009 0.106 0.151 10.0 -0.225 90.0 100.0 Nephrin/NEPH1/podocin/NCK1-2 0.03 0.093 0.228 1.0 -0.155 85.0 86.0 Nephrin/NEPH1/beta Arrestin2 0.008 0.081 -9999.0 0.0 -0.153 88.0 88.0 NPHS1 0.004 0.042 0.181 11.0 -9999.0 0.0 11.0 Nephrin/NEPH1/podocin 0.007 0.083 0.173 1.0 -0.16 90.0 91.0 TJP1 0.026 0.005 -9999.0 0.0 -9999.0 0.0 0.0 NCK1 0.025 0.007 -9999.0 0.0 -9999.0 0.0 0.0 NCK2 0.027 0.003 -9999.0 0.0 -9999.0 0.0 0.0 heterophilic cell adhesion 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 Nephrin/NEPH1/podocin/PLCgamma1 0.022 0.094 0.222 1.0 -0.167 88.0 89.0 CD2AP 0.027 0.004 -9999.0 0.0 -9999.0 0.0 0.0 Nephrin/NEPH1/podocin/GRB2 0.022 0.094 0.222 1.0 -0.167 87.0 88.0 GRB2 0.026 0.005 -9999.0 0.0 -9999.0 0.0 0.0 homophilic cell adhesion 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 TRPC6 -0.051 0.095 0.223 12.0 -0.196 115.0 127.0 cytoskeleton organization -0.027 0.076 0.205 3.0 -0.195 76.0 79.0 Nephrin/NEPH1 0.0 0.074 0.152 1.0 -0.149 90.0 91.0 Nephrin/NEPH1/ZO-1 0.01 0.091 0.18 1.0 -0.177 88.0 89.0