Syndecan-4-mediated signaling events Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations PTK2 0.026 0.079 0.212 2.0 -0.361 13.0 15.0 Syndecan-4/Syndesmos 0.036 0.119 0.322 5.0 -0.56 12.0 17.0 positive regulation of JNK cascade 0.039 0.117 0.31 2.0 -0.507 14.0 16.0 Syndecan-4/ADAM12 0.037 0.123 0.275 5.0 -0.536 14.0 19.0 CCL5 0.02 0.055 0.166 6.0 -0.308 12.0 18.0 Rac1/GDP 0.018 0.006 -9999.0 0.0 -9999.0 0.0 0.0 DNM2 0.027 0.004 -9999.0 0.0 -9999.0 0.0 0.0 ITGA5 0.018 0.055 0.166 1.0 -0.308 13.0 14.0 SDCBP 0.023 0.01 -9999.0 0.0 -9999.0 0.0 0.0 PLG 0.025 0.036 0.162 23.0 -0.119 2.0 25.0 ADAM12 0.028 0.044 0.166 19.0 -0.308 5.0 24.0 mol:GTP 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 NUDT16L1 0.026 0.005 -9999.0 0.0 -9999.0 0.0 0.0 mol:PI-4-5-P2 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 Syndecan-4/PKC alpha -0.049 0.025 0.025 5.0 -0.09 28.0 33.0 Syndecan-4/Laminin alpha1 0.033 0.125 0.319 5.0 -0.525 15.0 20.0 Syndecan-4/CXCL12/CXCR4 0.041 0.125 0.324 2.0 -0.542 14.0 16.0 Syndecan-4/Laminin alpha3 0.027 0.125 0.268 3.0 -0.505 17.0 20.0 MDK 0.031 0.026 0.166 16.0 -9999.0 0.0 16.0 Syndecan-4/FZD7 0.034 0.127 0.314 6.0 -0.501 18.0 24.0 Syndecan-4/Midkine 0.04 0.121 0.314 5.0 -0.565 12.0 17.0 FZD7 0.016 0.06 -9999.0 0.0 -0.308 16.0 16.0 Syndecan-4/FGFR1/FGF 0.028 0.122 -9999.0 0.0 -0.512 15.0 15.0 THBS1 0.017 0.062 0.166 5.0 -0.308 16.0 21.0 integrin-mediated signaling pathway 0.031 0.117 0.317 5.0 -0.475 16.0 21.0 positive regulation of MAPKKK cascade 0.039 0.117 0.31 2.0 -0.507 14.0 16.0 Syndecan-4/TACI 0.041 0.128 0.313 6.0 -0.542 14.0 20.0 CXCR4 0.025 0.027 0.166 5.0 -0.308 2.0 7.0 cell adhesion 0.005 0.058 0.195 7.0 -0.255 15.0 22.0 Syndecan-4/Dynamin 0.037 0.122 0.314 6.0 -0.534 14.0 20.0 Syndecan-4/TSP1 0.034 0.121 0.324 4.0 -0.49 16.0 20.0 Syndecan-4/GIPC 0.036 0.122 0.314 6.0 -0.534 14.0 20.0 Syndecan-4/RANTES 0.036 0.127 0.311 5.0 -0.493 18.0 23.0 ITGB1 0.027 0.004 -9999.0 0.0 -9999.0 0.0 0.0 LAMA1 0.02 0.072 0.166 24.0 -0.308 18.0 42.0 LAMA3 0.001 0.088 0.166 1.0 -0.308 36.0 37.0 RAC1 0.025 0.008 -9999.0 0.0 -9999.0 0.0 0.0 PRKCA -0.01 0.115 0.73 9.0 -0.287 16.0 25.0 Syndecan-4/alpha-Actinin 0.035 0.124 0.314 6.0 -0.516 15.0 21.0 TFPI 0.025 0.052 0.166 15.0 -0.308 9.0 24.0 F2 0.031 0.035 0.166 24.0 -0.142 1.0 25.0 alpha5/beta1 Integrin 0.032 0.042 -9999.0 0.0 -0.214 13.0 13.0 positive regulation of cell adhesion 0.016 0.122 0.266 3.0 -0.513 17.0 20.0 ACTN1 0.022 0.037 -9999.0 0.0 -0.308 6.0 6.0 TNC 0.008 0.076 -9999.0 0.0 -0.308 26.0 26.0 Syndecan-4/CXCL12 0.033 0.121 0.303 3.0 -0.524 15.0 18.0 FGF6 0.018 0.011 0.166 2.0 -9999.0 0.0 2.0 RHOA 0.027 0.005 -9999.0 0.0 -9999.0 0.0 0.0 CXCL12 0.016 0.06 0.166 1.0 -0.308 16.0 17.0 TNFRSF13B 0.032 0.055 0.166 41.0 -0.308 6.0 47.0 FGF2 0.004 0.084 0.166 1.0 -0.308 32.0 33.0 FGFR1 0.019 0.024 -9999.0 0.0 -0.308 2.0 2.0 Syndecan-4/PI-4-5-P2 0.017 0.115 0.303 3.0 -0.531 14.0 17.0 mol:GDP -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 FN1 0.019 0.049 0.162 4.0 -0.27 11.0 15.0 cell migration -0.027 0.014 -9999.0 0.0 -9999.0 0.0 0.0 PRKCD 0.024 0.018 -9999.0 0.0 -0.126 2.0 2.0 vasculogenesis 0.034 0.116 0.319 4.0 -0.469 16.0 20.0 SDC4 0.021 0.122 0.332 3.0 -0.565 14.0 17.0 Syndecan-4/Tenascin C 0.031 0.122 0.322 5.0 -0.498 16.0 21.0 Syndecan-4/PI-4-5-P2/PKC alpha -0.04 0.02 -9999.0 0.0 -0.078 7.0 7.0 Syndecan-4/Syntenin 0.03 0.109 0.297 2.0 -0.537 11.0 13.0 MMP9 0.095 0.081 0.163 258.0 -0.307 5.0 263.0 Rac1/GTP 0.005 0.059 0.196 7.0 -0.261 15.0 22.0 cytoskeleton organization 0.036 0.115 0.317 5.0 -0.534 12.0 17.0 GIPC1 0.027 0.003 -9999.0 0.0 -9999.0 0.0 0.0 Syndecan-4/TFPI 0.037 0.126 0.342 5.0 -0.51 16.0 21.0