Signaling events mediated by the Hedgehog family Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations TGFB2 0.007 0.115 -9999.0 0.0 -0.501 20.0 20.0 IHH 0.037 0.072 0.207 30.0 -0.19 21.0 51.0 SHH Np/Cholesterol/GAS1 -0.023 0.08 0.114 1.0 -0.174 95.0 96.0 LRPAP1 0.027 0.004 -9999.0 0.0 -9999.0 0.0 0.0 dorsoventral neural tube patterning 0.023 0.08 0.173 95.0 -0.113 1.0 96.0 SMO/beta Arrestin2 0.015 0.095 -9999.0 0.0 -0.329 20.0 20.0 SMO 0.0 0.086 -9999.0 0.0 -0.342 20.0 20.0 AKT1 0.001 0.094 -9999.0 0.0 -0.39 13.0 13.0 ARRB2 0.025 0.007 -9999.0 0.0 -9999.0 0.0 0.0 BOC 0.018 0.052 -9999.0 0.0 -0.308 12.0 12.0 ADRBK1 0.026 0.006 -9999.0 0.0 -9999.0 0.0 0.0 heart looping 0.0 0.085 -9999.0 0.0 -0.337 20.0 20.0 STIL -0.011 0.094 0.193 27.0 -0.283 21.0 48.0 DHH N/PTCH2 0.037 0.035 0.139 6.0 -0.214 8.0 14.0 DHH N/PTCH1 0.021 0.077 -9999.0 0.0 -0.233 34.0 34.0 PIK3CA 0.023 0.027 -9999.0 0.0 -0.308 3.0 3.0 DHH 0.024 0.039 0.166 3.0 -0.308 6.0 9.0 PTHLH -0.005 0.149 -9999.0 0.0 -0.64 20.0 20.0 determination of left/right symmetry 0.0 0.085 -9999.0 0.0 -0.337 20.0 20.0 PIK3R1 0.023 0.027 -9999.0 0.0 -0.308 3.0 3.0 skeletal system development -0.005 0.147 -9999.0 0.0 -0.634 20.0 20.0 IHH N/Hhip 0.016 0.107 0.191 2.0 -0.272 51.0 53.0 DHH N/Hhip 0.015 0.078 -9999.0 0.0 -0.214 49.0 49.0 mol:Cholesterol 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 heart development 0.0 0.085 -9999.0 0.0 -0.337 20.0 20.0 pancreas development -0.002 0.096 0.166 3.0 -0.307 43.0 46.0 HHAT 0.023 0.034 -9999.0 0.0 -0.308 5.0 5.0 PI3K 0.032 0.033 -9999.0 0.0 -0.249 5.0 5.0 EntrezGene:84976 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 GAS1 -0.005 0.098 0.166 1.0 -0.308 45.0 46.0 somite specification 0.0 0.085 -9999.0 0.0 -0.337 20.0 20.0 SHH Np/Cholesterol/PTCH1 -0.009 0.087 0.18 2.0 -0.27 25.0 27.0 SHH Np/Cholesterol/PTCH2 -0.01 0.068 0.131 4.0 -0.164 70.0 74.0 SHH Np/Cholesterol/Megalin -0.021 0.081 0.123 8.0 -0.17 97.0 105.0 SHH -0.041 0.078 0.256 5.0 -0.217 67.0 72.0 catabolic process 0.008 0.079 -9999.0 0.0 -0.266 34.0 34.0 SMO/Vitamin D3 -0.011 0.094 0.302 1.0 -0.299 25.0 26.0 SHH Np/Cholesterol/Hhip -0.023 0.087 0.138 3.0 -0.19 89.0 92.0 LRP2 0.001 0.094 0.166 8.0 -0.308 39.0 47.0 receptor-mediated endocytosis -0.026 0.103 -9999.0 0.0 -0.321 29.0 29.0 SHH Np/Cholesterol/BOC -0.014 0.07 0.174 1.0 -0.165 76.0 77.0 SHH Np/Cholesterol/CDO -0.01 0.066 0.134 3.0 -0.16 70.0 73.0 mesenchymal cell differentiation 0.023 0.087 0.189 89.0 -0.137 3.0 92.0 mol:Vitamin D3 -0.004 0.098 0.197 25.0 -0.286 22.0 47.0 IHH N/PTCH2 0.037 0.065 0.152 27.0 -0.203 23.0 50.0 CDON 0.026 0.02 0.166 3.0 -0.308 1.0 4.0 IHH N/PTCH1 0.023 0.088 0.244 1.0 -0.268 34.0 35.0 Megalin/LRPAP1 0.018 0.071 0.139 8.0 -0.211 40.0 48.0 PTCH2 0.027 0.024 0.166 3.0 -0.308 2.0 5.0 SHH Np/Cholesterol -0.017 0.061 -9999.0 0.0 -0.158 71.0 71.0 PTCH1 0.008 0.08 -9999.0 0.0 -0.267 34.0 34.0 HHIP -0.002 0.096 0.166 3.0 -0.308 43.0 46.0