Stabilization and expansion of the E-cadherin adherens junction Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations adherens junction organization 0.019 0.01 -9999.0 0.0 -9999.0 0.0 0.0 epithelial cell differentiation 0.048 0.024 -9999.0 0.0 -9999.0 0.0 0.0 CYFIP2 0.027 0.005 -9999.0 0.0 -9999.0 0.0 0.0 ENAH -0.008 0.088 0.378 15.0 -9999.0 0.0 15.0 EGFR -0.002 0.09 -9999.0 0.0 -0.308 38.0 38.0 EPHA2 -0.002 0.096 0.166 3.0 -0.308 43.0 46.0 MYO6 0.007 0.054 0.19 23.0 -9999.0 0.0 23.0 CTNNB1 0.027 0.005 -9999.0 0.0 -9999.0 0.0 0.0 ABI1/Sra1/Nap1 0.051 0.015 -9999.0 0.0 -9999.0 0.0 0.0 AQP5 -0.141 0.194 -9999.0 0.0 -0.389 181.0 181.0 CTNND1 0.027 0.004 -9999.0 0.0 -9999.0 0.0 0.0 mol:PI-4-5-P2 -0.001 0.052 0.195 28.0 -9999.0 0.0 28.0 regulation of calcium-dependent cell-cell adhesion -0.003 0.057 0.195 28.0 -0.15 11.0 39.0 EGF 0.023 0.08 0.166 38.0 -0.308 21.0 59.0 NCKAP1 0.026 0.005 -9999.0 0.0 -9999.0 0.0 0.0 AQP3 0.003 0.067 0.346 2.0 -0.373 12.0 14.0 cortical microtubule organization 0.048 0.024 -9999.0 0.0 -9999.0 0.0 0.0 GO:0000145 -0.002 0.049 0.183 28.0 -9999.0 0.0 28.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin 0.053 0.026 -9999.0 0.0 -9999.0 0.0 0.0 MLLT4 0.026 0.005 -9999.0 0.0 -9999.0 0.0 0.0 ARF6/GDP -0.032 0.034 -9999.0 0.0 -0.147 27.0 27.0 ARF6 0.027 0.004 -9999.0 0.0 -9999.0 0.0 0.0 Ephrin A1/EPHA2/NCK1/GIT1 0.043 0.067 -9999.0 0.0 -0.166 39.0 39.0 mol:Ca2+ -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 VASP -0.004 0.035 0.168 10.0 -9999.0 0.0 10.0 PVRL2 0.027 0.004 -9999.0 0.0 -9999.0 0.0 0.0 ZYX -0.005 0.042 0.197 17.0 -9999.0 0.0 17.0 ARF6/GTP 0.048 0.067 -9999.0 0.0 -0.157 39.0 39.0 CDH1 0.024 0.009 -9999.0 0.0 -9999.0 0.0 0.0 EGFR/EGFR/EGF/EGF 0.022 0.067 -9999.0 0.0 -0.151 52.0 52.0 RhoA/GDP 0.049 0.024 -9999.0 0.0 -9999.0 0.0 0.0 actin cytoskeleton organization -0.013 0.041 0.162 18.0 -0.16 1.0 19.0 IGF-1R heterotetramer 0.027 0.017 0.166 1.0 -0.307 1.0 2.0 GIT1 0.027 0.002 -9999.0 0.0 -9999.0 0.0 0.0 IGF1R 0.027 0.017 0.166 1.0 -0.308 1.0 2.0 IGF1 0.009 0.088 0.166 17.0 -0.308 32.0 49.0 DIAPH1 0.025 0.12 -9999.0 0.0 -0.551 6.0 6.0 Wnt receptor signaling pathway -0.048 0.024 -9999.0 0.0 -9999.0 0.0 0.0 RHOA 0.027 0.005 -9999.0 0.0 -9999.0 0.0 0.0 RhoA/GTP -0.032 0.034 -9999.0 0.0 -0.146 27.0 27.0 CTNNA1 0.026 0.006 -9999.0 0.0 -9999.0 0.0 0.0 VCL -0.013 0.041 0.164 18.0 -0.163 1.0 19.0 EFNA1 0.026 0.006 -9999.0 0.0 -9999.0 0.0 0.0 LPP -0.014 0.047 0.184 15.0 -9999.0 0.0 15.0 Ephrin A1/EPHA2 0.027 0.057 -9999.0 0.0 -0.143 40.0 40.0 SEC6/SEC8 -0.02 0.011 -9999.0 0.0 -9999.0 0.0 0.0 MGAT3 -0.003 0.058 0.197 28.0 -0.152 11.0 39.0 HGF/MET 0.021 0.07 -9999.0 0.0 -0.179 44.0 44.0 HGF 0.011 0.076 0.166 9.0 -0.308 24.0 33.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin/EPLIN 0.019 0.01 -9999.0 0.0 -9999.0 0.0 0.0 actin cable formation 0.017 0.112 0.311 41.0 -0.231 6.0 47.0 KIAA1543 -0.005 0.044 0.184 21.0 -0.145 1.0 22.0 KIFC3 -0.005 0.044 0.191 21.0 -9999.0 0.0 21.0 NCK1 0.025 0.007 -9999.0 0.0 -9999.0 0.0 0.0 EXOC3 0.026 0.005 -9999.0 0.0 -9999.0 0.0 0.0 ACTN1 -0.004 0.047 0.194 22.0 -9999.0 0.0 22.0 NCK1/GIT1 0.037 0.011 -9999.0 0.0 -9999.0 0.0 0.0 mol:GDP 0.048 0.024 -9999.0 0.0 -9999.0 0.0 0.0 EXOC4 0.025 0.008 -9999.0 0.0 -9999.0 0.0 0.0 STX4 -0.002 0.05 0.199 25.0 -9999.0 0.0 25.0 PIP5K1C -0.001 0.052 0.197 28.0 -9999.0 0.0 28.0 LIMA1 0.027 0.004 -9999.0 0.0 -9999.0 0.0 0.0 ABI1 0.027 0.004 -9999.0 0.0 -9999.0 0.0 0.0 ROCK1 -0.004 0.097 0.401 15.0 -9999.0 0.0 15.0 adherens junction assembly -0.008 0.098 0.262 20.0 -0.498 8.0 28.0 IGF-1R heterotetramer/IGF1 0.032 0.049 0.158 1.0 -0.143 26.0 27.0 nectin-2(dimer)/I-afadin/I-afadin/nectin-2(dimer/I-afadin/I-afadin 0.039 0.009 -9999.0 0.0 -9999.0 0.0 0.0 MET -0.002 0.091 -9999.0 0.0 -0.308 39.0 39.0 PLEKHA7 -0.004 0.046 0.195 21.0 -9999.0 0.0 21.0 mol:GTP 0.041 0.066 -9999.0 0.0 -0.165 39.0 39.0 establishment of epithelial cell apical/basal polarity 0.005 0.091 0.315 27.0 -9999.0 0.0 27.0 cortical actin cytoskeleton stabilization 0.019 0.01 -9999.0 0.0 -9999.0 0.0 0.0 regulation of cell-cell adhesion -0.013 0.041 0.162 18.0 -0.16 1.0 19.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin/EPLIN/cortical actin cytoskeleton 0.019 0.01 -9999.0 0.0 -9999.0 0.0 0.0