Insulin Pathway Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations CBL/APS/CAP 0.019 0.079 -9999.0 0.0 -0.167 63.0 63.0 TC10/GTP 0.018 0.064 -9999.0 0.0 -0.15 53.0 53.0 Insulin Receptor/Insulin/IRS1/Shp2 0.056 0.048 -9999.0 0.0 -0.184 13.0 13.0 HRAS 0.028 0.015 0.166 5.0 -9999.0 0.0 5.0 APS homodimer 0.028 0.029 0.166 14.0 -0.307 1.0 15.0 GRB14 0.048 0.06 0.166 82.0 -0.308 3.0 85.0 FOXO3 -0.128 0.261 -9999.0 0.0 -0.556 127.0 127.0 AKT1 -0.01 0.08 0.196 40.0 -0.284 5.0 45.0 INSR 0.029 0.007 -9999.0 0.0 -9999.0 0.0 0.0 Insulin Receptor/Insulin 0.057 0.028 -9999.0 0.0 -9999.0 0.0 0.0 mol:GTP 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 GRB10 0.025 0.008 -9999.0 0.0 -9999.0 0.0 0.0 SORBS1 -0.022 0.117 -9999.0 0.0 -0.308 69.0 69.0 CRK 0.025 0.007 -9999.0 0.0 -9999.0 0.0 0.0 PTPN1 -0.006 0.021 0.152 8.0 -9999.0 0.0 8.0 CAV1 -0.03 0.058 0.199 4.0 -0.179 50.0 54.0 CBL/APS/CAP/Crk-II/C3G 0.038 0.08 -9999.0 0.0 -0.16 54.0 54.0 Insulin Receptor/Insulin/IRS1/NCK2 0.06 0.044 -9999.0 0.0 -0.173 12.0 12.0 mol:GDP 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 mol:PI-3-4-5-P3 0.04 0.048 -9999.0 0.0 -0.201 13.0 13.0 Insulin Receptor/Insuli/IRS1/GRB2/SHC/PTP1B 0.019 0.051 -9999.0 0.0 -0.323 4.0 4.0 RPS6KB1 -0.014 0.073 0.179 41.0 -0.267 5.0 46.0 PARD6A 0.025 0.016 0.166 4.0 -9999.0 0.0 4.0 CBL 0.025 0.016 -9999.0 0.0 -0.308 1.0 1.0 tumor necrosis factor-mediated signaling pathway 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 DOK1 0.014 0.06 -9999.0 0.0 -0.568 5.0 5.0 PIK3R1 0.023 0.027 -9999.0 0.0 -0.308 3.0 3.0 Insulin Receptor/Insuli/IRS1/GRB2/Shc 0.023 0.061 0.163 9.0 -0.246 7.0 16.0 HRAS/GTP -0.032 0.038 -9999.0 0.0 -0.168 28.0 28.0 Insulin Receptor 0.029 0.007 -9999.0 0.0 -9999.0 0.0 0.0 Insulin Receptor/Insuli/IRS1/GRB2/SHC 0.066 0.048 -9999.0 0.0 -0.163 13.0 13.0 PRKCI 0.021 0.051 -9999.0 0.0 -0.303 9.0 9.0 Insulin Receptor/Insulin/GRB14/PDK1 0.025 0.048 -9999.0 0.0 -0.206 14.0 14.0 SHC1 0.026 0.006 -9999.0 0.0 -9999.0 0.0 0.0 negative regulation of MAPKKK cascade 0.036 0.055 -9999.0 0.0 -0.419 5.0 5.0 PI3K 0.05 0.053 -9999.0 0.0 -0.203 13.0 13.0 NCK2 0.027 0.003 -9999.0 0.0 -9999.0 0.0 0.0 RHOQ 0.027 0.005 -9999.0 0.0 -9999.0 0.0 0.0 mol:H2O2 -0.001 0.002 -9999.0 0.0 -9999.0 0.0 0.0 HRAS/GDP 0.021 0.01 0.118 5.0 -9999.0 0.0 5.0 AKT2 -0.011 0.076 0.219 20.0 -0.284 5.0 25.0 PRKCZ 0.022 0.05 -9999.0 0.0 -0.303 9.0 9.0 SH2B2 0.028 0.029 0.166 14.0 -0.308 1.0 15.0 SHC/SHIP 0.012 0.054 0.166 6.0 -0.176 29.0 35.0 F2RL2 0.074 0.068 0.166 169.0 -9999.0 0.0 169.0 TRIP10 0.027 0.004 -9999.0 0.0 -9999.0 0.0 0.0 Insulin Receptor/Insulin/Shc 0.047 0.022 -9999.0 0.0 -9999.0 0.0 0.0 TC10/GTP/CIP4/Exocyst 0.035 0.008 -9999.0 0.0 -9999.0 0.0 0.0 Insulin Receptor/Insulin/SHC/GRB2/Sos1 0.07 0.031 -9999.0 0.0 -9999.0 0.0 0.0 RAPGEF1 0.026 0.006 -9999.0 0.0 -9999.0 0.0 0.0 RASA1 0.024 0.022 -9999.0 0.0 -0.308 2.0 2.0 NCK1 0.025 0.007 -9999.0 0.0 -9999.0 0.0 0.0 CBL/APS/CAP/Crk-II 0.028 0.079 -9999.0 0.0 -0.167 58.0 58.0 TC10/GDP 0.02 0.004 -9999.0 0.0 -9999.0 0.0 0.0 Insulin Receptor/Insulin/SHC/GRB10 0.058 0.03 -9999.0 0.0 -9999.0 0.0 0.0 INPP5D -0.022 0.05 0.183 8.0 -0.184 28.0 36.0 SOS1 0.026 0.005 -9999.0 0.0 -9999.0 0.0 0.0 SGK1 -0.114 0.292 -9999.0 0.0 -0.767 80.0 80.0 mol:cAMP 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 PTPN11 0.025 0.016 -9999.0 0.0 -0.308 1.0 1.0 IRS1 0.017 0.056 -9999.0 0.0 -0.308 14.0 14.0 p62DOK/RasGAP 0.036 0.055 -9999.0 0.0 -0.423 5.0 5.0 INS 0.024 0.025 0.178 12.0 -9999.0 0.0 12.0 mol:PI-3-4-P2 -0.022 0.05 0.182 8.0 -0.183 28.0 36.0 GRB2 0.026 0.005 -9999.0 0.0 -9999.0 0.0 0.0 EIF4EBP1 -0.019 0.059 0.177 21.0 -0.279 5.0 26.0 PTPRA 0.029 0.005 -9999.0 0.0 -9999.0 0.0 0.0 PIK3CA 0.023 0.027 -9999.0 0.0 -0.308 3.0 3.0 TC10/GTP/CIP4 0.035 0.008 -9999.0 0.0 -9999.0 0.0 0.0 PDPK1 0.026 0.006 -9999.0 0.0 -9999.0 0.0 0.0 Insulin Receptor/Insuli/IRS1/GRB2/SHC/Sos 0.017 0.037 -9999.0 0.0 -0.185 13.0 13.0 Insulin Receptor/Insulin/IRS1 0.043 0.04 -9999.0 0.0 -0.169 13.0 13.0 Insulin Receptor/Insulin/IRS3 0.038 0.02 0.147 12.0 -9999.0 0.0 12.0 Par3/Par6 0.073 0.059 0.223 2.0 -0.113 1.0 3.0