Signaling events mediated by Stem cell factor receptor (c-Kit) Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations MAP4K1 -0.048 0.15 0.293 2.0 -0.426 57.0 59.0 CRKL -0.049 0.154 -9999.0 0.0 -0.443 57.0 57.0 HRAS -0.025 0.153 -9999.0 0.0 -0.412 56.0 56.0 mol:PIP3 -0.018 0.154 0.235 6.0 -0.392 55.0 61.0 SPRED1 0.023 0.034 -9999.0 0.0 -0.308 5.0 5.0 SPRED2 0.023 0.034 -9999.0 0.0 -0.308 5.0 5.0 GAB1 -0.049 0.164 -9999.0 0.0 -0.462 59.0 59.0 FOXO3 -0.019 0.152 0.264 4.0 -0.391 52.0 56.0 AKT1 -0.018 0.165 0.277 3.0 -0.423 53.0 56.0 BAD -0.014 0.157 0.318 11.0 -0.395 52.0 63.0 megakaryocyte differentiation -0.049 0.159 -9999.0 0.0 -0.444 61.0 61.0 GSK3B -0.012 0.157 0.328 7.0 -0.393 52.0 59.0 RAF1 -0.02 0.126 0.233 6.0 -0.332 56.0 62.0 SHC1 0.026 0.006 -9999.0 0.0 -9999.0 0.0 0.0 STAT3 -0.05 0.163 -9999.0 0.0 -0.457 60.0 60.0 STAT1 -0.116 0.362 -9999.0 0.0 -0.99 66.0 66.0 HRAS/SPRED1 -0.008 0.133 -9999.0 0.0 -0.342 55.0 55.0 cell proliferation -0.052 0.162 -9999.0 0.0 -0.446 62.0 62.0 PIK3CA 0.023 0.027 -9999.0 0.0 -0.31 3.0 3.0 TEC 0.027 0.005 -9999.0 0.0 -9999.0 0.0 0.0 RPS6KB1 -0.031 0.173 -9999.0 0.0 -0.453 59.0 59.0 HRAS/SPRED2 -0.008 0.133 -9999.0 0.0 -0.341 56.0 56.0 LYN/TEC/p62DOK -0.007 0.159 -9999.0 0.0 -0.428 50.0 50.0 MAPK3 -0.007 0.101 0.257 14.0 -0.243 50.0 64.0 STAP1 -0.063 0.174 0.25 1.0 -0.493 59.0 60.0 GRAP2 0.016 0.061 0.166 2.0 -0.308 16.0 18.0 JAK2 -0.098 0.309 -9999.0 0.0 -0.876 61.0 61.0 STAT1 (dimer) -0.113 0.353 -9999.0 0.0 -0.964 66.0 66.0 mol:Gleevec 0.001 0.007 -9999.0 0.0 -9999.0 0.0 0.0 GRB2/SOCS1/VAV1 -0.013 0.178 -9999.0 0.0 -0.457 58.0 58.0 actin filament polymerization -0.045 0.152 0.218 3.0 -0.433 56.0 59.0 LYN 0.023 0.01 -9999.0 0.0 -9999.0 0.0 0.0 STAP1/STAT5A (dimer) -0.087 0.243 -9999.0 0.0 -0.668 64.0 64.0 PIK3R1 0.023 0.028 -9999.0 0.0 -0.309 3.0 3.0 CBL/CRKL/GRB2 -0.019 0.153 -9999.0 0.0 -0.406 57.0 57.0 PI3K -0.013 0.175 -9999.0 0.0 -0.45 56.0 56.0 PTEN 0.022 0.011 -9999.0 0.0 -9999.0 0.0 0.0 SCF/KIT/EPO/EPOR -0.116 0.414 -9999.0 0.0 -1.189 58.0 58.0 MAPK8 -0.053 0.166 -9999.0 0.0 -0.456 62.0 62.0 STAT3 (dimer) -0.049 0.159 -9999.0 0.0 -0.447 60.0 60.0 positive regulation of transcription -0.003 0.087 0.241 14.0 -0.202 46.0 60.0 mol:GDP -0.023 0.16 -9999.0 0.0 -0.424 58.0 58.0 PIK3C2B -0.048 0.161 -9999.0 0.0 -0.459 58.0 58.0 CBL/CRKL -0.03 0.154 -9999.0 0.0 -0.417 58.0 58.0 FER -0.052 0.166 -9999.0 0.0 -0.452 65.0 65.0 SH2B3 -0.048 0.16 -9999.0 0.0 -0.451 60.0 60.0 PDPK1 -0.013 0.147 0.263 14.0 -0.367 53.0 67.0 SNAI2 -0.068 0.178 -9999.0 0.0 -0.488 64.0 64.0 positive regulation of cell proliferation -0.083 0.28 -9999.0 0.0 -0.763 65.0 65.0 KITLG 0.002 0.079 -9999.0 0.0 -0.334 23.0 23.0 cell motility -0.083 0.28 -9999.0 0.0 -0.763 65.0 65.0 PTPN6 0.026 0.012 -9999.0 0.0 -9999.0 0.0 0.0 EPOR -0.006 0.126 -9999.0 0.0 -1.081 1.0 1.0 STAT5A (dimer) -0.069 0.238 -9999.0 0.0 -0.647 64.0 64.0 SOCS1 0.027 0.02 0.166 3.0 -0.308 1.0 4.0 cell migration 0.062 0.164 0.451 65.0 -0.192 1.0 66.0 SOS1 0.026 0.005 -9999.0 0.0 -9999.0 0.0 0.0 EPO -0.003 0.104 0.167 24.0 -0.316 42.0 66.0 VAV1 0.013 0.067 0.166 1.0 -0.308 20.0 21.0 GRB10 -0.048 0.154 -9999.0 0.0 -0.441 58.0 58.0 PTPN11 0.026 0.018 -9999.0 0.0 -0.297 1.0 1.0 SCF/KIT -0.047 0.172 -9999.0 0.0 -0.479 60.0 60.0 GO:0007205 0.002 0.008 -9999.0 0.0 -9999.0 0.0 0.0 MAP2K1 -0.012 0.108 0.268 12.0 -0.266 54.0 66.0 CBL 0.025 0.016 -9999.0 0.0 -0.308 1.0 1.0 KIT -0.121 0.411 -9999.0 0.0 -1.217 58.0 58.0 MAP2K2 -0.013 0.107 0.256 12.0 -0.266 54.0 66.0 SHC/Grb2/SOS1 -0.007 0.166 -9999.0 0.0 -0.435 56.0 56.0 STAT5A -0.072 0.246 -9999.0 0.0 -0.67 64.0 64.0 GRB2 0.026 0.005 -9999.0 0.0 -9999.0 0.0 0.0 response to radiation -0.067 0.174 -9999.0 0.0 -0.478 64.0 64.0 SHC/GRAP2 0.03 0.045 0.139 2.0 -0.214 15.0 17.0 PTPRO -0.049 0.161 -9999.0 0.0 -0.454 60.0 60.0 SH2B2 -0.046 0.155 0.219 3.0 -0.443 56.0 59.0 DOK1 0.027 0.004 -9999.0 0.0 -9999.0 0.0 0.0 MATK -0.063 0.167 -9999.0 0.0 -0.461 65.0 65.0 CREBBP 0.018 0.054 -9999.0 0.0 -0.147 17.0 17.0 BCL2 -0.104 0.361 -9999.0 0.0 -1.166 40.0 40.0