Pathway Name	Avg Num Perturbations	Total Perturbations	Num Entities	Min Mean Truth	Max Mean Truth	Min Mean Within	Max Mean Within	Min Mean Any	Max Mean Within
Ephrin A  reverse signaling	94.0	659.0	7.0	-0.048	-0.0	1000.0	-1000.0	-0.012	-1000.0
Angiopoietin receptor Tie2-mediated signaling	90.0	7962.0	88.0	-0.297	0.075	1000.0	-1000.0	-0.05	-1000.0
Signaling mediated by p38-alpha and p38-beta	87.0	3867.0	44.0	-0.154	0.027	1000.0	-1000.0	-0.015	-1000.0
Endothelins	80.0	7733.0	96.0	-0.193	0.028	1000.0	-1000.0	-0.029	-1000.0
Glucocorticoid receptor regulatory network	66.0	7546.0	114.0	-0.409	0.216	1000.0	-1000.0	-0.043	-1000.0
Nephrin/Neph1 signaling in the kidney podocyte	56.0	1932.0	34.0	-0.051	0.03	1000.0	-1000.0	-0.028	-1000.0
Reelin signaling pathway	51.0	2874.0	56.0	-0.094	0.066	1000.0	-1000.0	-0.022	-1000.0
IL23-mediated signaling events	50.0	3015.0	60.0	-0.31	0.046	1000.0	-1000.0	-0.096	-1000.0
Thromboxane A2 receptor signaling	49.0	5167.0	105.0	-0.12	0.037	1000.0	-1000.0	-0.028	-1000.0
Integrins in angiogenesis	46.0	3910.0	84.0	-0.099	0.08	1000.0	-1000.0	-0.024	-1000.0
EPHB forward signaling	46.0	3994.0	85.0	-0.073	0.092	1000.0	-1000.0	-0.044	-1000.0
Signaling events mediated by Stem cell factor receptor (c-Kit)	44.0	3433.0	78.0	-0.121	0.062	1000.0	-1000.0	-0.047	-1000.0
S1P5 pathway	42.0	720.0	17.0	-0.045	0.042	1000.0	-1000.0	-0.001	-1000.0
Aurora B signaling	42.0	2876.0	67.0	-0.095	0.114	1000.0	-1000.0	-0.032	-1000.0
Ras signaling in the CD4+ TCR pathway	41.0	700.0	17.0	-0.079	0.041	1000.0	-1000.0	-0.013	-1000.0
LPA receptor mediated events	40.0	4118.0	102.0	-0.057	0.097	1000.0	-1000.0	-0.062	-1000.0
Calcineurin-regulated NFAT-dependent transcription in lymphocytes	39.0	2664.0	68.0	-0.158	0.061	1000.0	-1000.0	-0.074	-1000.0
Noncanonical Wnt signaling pathway	38.0	1006.0	26.0	-0.041	0.027	1000.0	-1000.0	-0.027	-1000.0
Ephrin B reverse signaling	38.0	1860.0	48.0	-0.067	0.034	1000.0	-1000.0	-0.031	-1000.0
S1P1 pathway	37.0	1332.0	36.0	-0.191	0.027	1000.0	-1000.0	-0.026	-1000.0
p75(NTR)-mediated signaling	36.0	4561.0	125.0	-0.073	0.073	1000.0	-1000.0	-0.05	-1000.0
IL6-mediated signaling events	36.0	2746.0	75.0	-0.165	0.033	1000.0	-1000.0	-0.042	-1000.0
Signaling events mediated by the Hedgehog family	35.0	1851.0	52.0	-0.041	0.037	1000.0	-1000.0	-0.02	-1000.0
HIF-1-alpha transcription factor network	35.0	2716.0	76.0	-0.076	0.071	1000.0	-1000.0	-0.055	-1000.0
EPO signaling pathway	35.0	1973.0	55.0	-0.019	0.048	1000.0	-1000.0	-0.021	-1000.0
Glypican 2 network	35.0	142.0	4.0	0.031	0.06	1000.0	-1000.0	0.022	-1000.0
Glypican 1 network	34.0	1632.0	48.0	-0.034	0.061	1000.0	-1000.0	-0.023	-1000.0
Nongenotropic Androgen signaling	34.0	1805.0	52.0	-0.117	0.06	1000.0	-1000.0	-0.015	-1000.0
EGFR-dependent Endothelin signaling events	34.0	722.0	21.0	-0.03	0.046	1000.0	-1000.0	-0.029	-1000.0
Osteopontin-mediated events	33.0	1275.0	38.0	-0.053	0.05	1000.0	-1000.0	-0.021	-1000.0
amb2 Integrin signaling	33.0	2718.0	82.0	-0.118	0.097	1000.0	-1000.0	-0.028	-1000.0
Wnt signaling	33.0	236.0	7.0	-0.032	0.027	1000.0	-1000.0	-0.001	-1000.0
S1P4 pathway	33.0	839.0	25.0	-0.045	0.048	1000.0	-1000.0	-0.014	-1000.0
Syndecan-1-mediated signaling events	32.0	1096.0	34.0	-0.021	0.097	1000.0	-1000.0	-0.023	-1000.0
JNK signaling in the CD4+ TCR pathway	32.0	555.0	17.0	-0.118	0.065	1000.0	-1000.0	-0.019	-1000.0
Calcium signaling in the CD4+ TCR pathway	32.0	999.0	31.0	-0.089	0.032	1000.0	-1000.0	-0.032	-1000.0
BMP receptor signaling	30.0	2470.0	81.0	-0.08	0.066	1000.0	-1000.0	-0.019	-1000.0
Effects of Botulinum toxin	30.0	799.0	26.0	-0.028	0.049	1000.0	-1000.0	-0.011	-1000.0
Neurotrophic factor-mediated Trk receptor signaling	30.0	3678.0	120.0	-0.075	0.085	1000.0	-1000.0	-0.037	-1000.0
Signaling events regulated by Ret tyrosine kinase	29.0	2444.0	82.0	-0.031	0.044	1000.0	-1000.0	-0.036	-1000.0
RXR and RAR heterodimerization with other nuclear receptor	28.0	1498.0	52.0	-0.051	0.069	1000.0	-1000.0	-0.022	-1000.0
FOXM1 transcription factor network	27.0	1378.0	51.0	-0.1	0.065	1000.0	-1000.0	-0.104	-1000.0
Arf6 signaling events	26.0	1669.0	62.0	-0.036	0.043	1000.0	-1000.0	-0.024	-1000.0
Fc-epsilon receptor I signaling in mast cells	26.0	2617.0	97.0	-0.068	0.04	1000.0	-1000.0	-0.051	-1000.0
PLK1 signaling events	26.0	2260.0	85.0	-0.025	0.081	1000.0	-1000.0	-0.013	-1000.0
TCR signaling in naïve CD8+ T cells	26.0	2488.0	93.0	-0.054	0.073	1000.0	-1000.0	-0.031	-1000.0
ErbB2/ErbB3 signaling events	25.0	1626.0	65.0	-0.081	0.038	1000.0	-1000.0	-0.056	-1000.0
Signaling events activated by Hepatocyte Growth Factor Receptor (c-Met)	25.0	2175.0	85.0	-0.12	0.035	1000.0	-1000.0	-0.027	-1000.0
IL12-mediated signaling events	24.0	2147.0	87.0	-0.175	0.065	1000.0	-1000.0	-0.053	-1000.0
Visual signal transduction: Cones	24.0	913.0	38.0	-0.041	0.042	1000.0	-1000.0	-0.022	-1000.0
IL4-mediated signaling events	24.0	2202.0	91.0	-0.256	0.13	1000.0	-1000.0	-0.136	-1000.0
Plasma membrane estrogen receptor signaling	24.0	2093.0	86.0	-0.129	0.056	1000.0	-1000.0	-0.029	-1000.0
Aurora C signaling	23.0	165.0	7.0	-0.0	0.065	1000.0	-1000.0	-0.009	-1000.0
S1P3 pathway	23.0	994.0	42.0	-0.027	0.04	1000.0	-1000.0	-0.019	-1000.0
Rapid glucocorticoid signaling	23.0	478.0	20.0	-0.053	0.034	1000.0	-1000.0	-0.011	-1000.0
Lissencephaly gene (LIS1) in neuronal migration and development	22.0	1208.0	54.0	-0.094	0.066	1000.0	-1000.0	-0.021	-1000.0
Presenilin action in Notch and Wnt signaling	22.0	1371.0	61.0	-0.121	0.074	1000.0	-1000.0	-0.033	-1000.0
PDGFR-alpha signaling pathway	22.0	1001.0	44.0	-0.133	0.052	1000.0	-1000.0	-0.026	-1000.0
FAS signaling pathway (CD95)	22.0	1047.0	47.0	-0.227	0.042	1000.0	-1000.0	-0.035	-1000.0
Canonical Wnt signaling pathway	22.0	1136.0	51.0	-0.121	0.114	1000.0	-1000.0	-0.035	-1000.0
Syndecan-2-mediated signaling events	21.0	1507.0	69.0	-0.008	0.045	1000.0	-1000.0	-0.029	-1000.0
Regulation of p38-alpha and p38-beta	21.0	1157.0	54.0	-0.099	0.06	1000.0	-1000.0	-0.039	-1000.0
BCR signaling pathway	21.0	2102.0	99.0	-0.109	0.064	1000.0	-1000.0	-0.047	-1000.0
Visual signal transduction: Rods	21.0	1101.0	52.0	-0.041	0.058	1000.0	-1000.0	-0.013	-1000.0
BARD1 signaling events	20.0	1172.0	57.0	-0.03	0.046	1000.0	-1000.0	-0.042	-1000.0
Signaling events mediated by PTP1B	20.0	1592.0	76.0	-0.14	0.094	1000.0	-1000.0	-0.024	-1000.0
Signaling events mediated by VEGFR1 and VEGFR2	19.0	2483.0	125.0	-0.059	0.052	1000.0	-1000.0	-0.028	-1000.0
Syndecan-4-mediated signaling events	19.0	1308.0	67.0	-0.049	0.095	1000.0	-1000.0	-0.029	-1000.0
IGF1 pathway	19.0	1130.0	57.0	-0.016	0.06	1000.0	-1000.0	-0.025	-1000.0
IL27-mediated signaling events	18.0	933.0	51.0	-0.344	0.074	1000.0	-1000.0	-0.039	-1000.0
Insulin Pathway	18.0	1349.0	74.0	-0.128	0.074	1000.0	-1000.0	-0.037	-1000.0
Caspase cascade in apoptosis	17.0	1259.0	74.0	-0.038	0.064	1000.0	-1000.0	-0.027	-1000.0
a4b1 and a4b7 Integrin signaling	17.0	87.0	5.0	0.016	0.034	1000.0	-1000.0	0.02	-1000.0
Ceramide signaling pathway	17.0	1305.0	76.0	-0.021	0.072	1000.0	-1000.0	-0.023	-1000.0
IL1-mediated signaling events	17.0	1113.0	62.0	-0.037	0.067	1000.0	-1000.0	-0.023	-1000.0
Stabilization and expansion of the E-cadherin adherens junction	17.0	1330.0	74.0	-0.141	0.053	1000.0	-1000.0	-0.044	-1000.0
TCGA08_retinoblastoma	17.0	137.0	8.0	-0.009	0.056	1000.0	-1000.0	-0.002	-1000.0
Hypoxic and oxygen homeostasis regulation of HIF-1-alpha	17.0	576.0	33.0	-0.067	0.061	1000.0	-1000.0	-0.016	-1000.0
TCGA08_p53	16.0	115.0	7.0	-0.014	0.026	1000.0	-1000.0	-0.01	-1000.0
VEGFR1 specific signals	16.0	940.0	56.0	-0.055	0.041	1000.0	-1000.0	-0.032	-1000.0
Regulation of nuclear SMAD2/3 signaling	15.0	2047.0	136.0	-0.069	0.146	1000.0	-1000.0	-0.033	-1000.0
Coregulation of Androgen receptor activity	15.0	1166.0	76.0	-0.016	0.065	1000.0	-1000.0	-0.025	-1000.0
ErbB4 signaling events	15.0	1060.0	69.0	-0.081	0.059	1000.0	-1000.0	-0.031	-1000.0
Sphingosine 1-phosphate (S1P) pathway	15.0	421.0	28.0	-0.027	0.052	1000.0	-1000.0	-0.02	-1000.0
Cellular roles of Anthrax toxin	15.0	598.0	39.0	-0.023	0.026	1000.0	-1000.0	-0.015	-1000.0
Hedgehog signaling events mediated by Gli proteins	15.0	1006.0	65.0	-0.223	0.066	1000.0	-1000.0	-0.031	-1000.0
Class I PI3K signaling events	15.0	1120.0	73.0	-0.042	0.064	1000.0	-1000.0	-0.025	-1000.0
Aurora A signaling	14.0	864.0	60.0	-0.063	0.072	1000.0	-1000.0	-0.024	-1000.0
mTOR signaling pathway	14.0	774.0	53.0	-0.143	0.051	1000.0	-1000.0	-0.02	-1000.0
Nectin adhesion pathway	14.0	929.0	63.0	-0.036	0.062	1000.0	-1000.0	-0.035	-1000.0
Paxillin-independent events mediated by a4b1 and a4b7	14.0	550.0	37.0	-0.019	0.062	1000.0	-1000.0	-0.02	-1000.0
ceramide signaling pathway	14.0	730.0	49.0	-0.0	0.038	1000.0	-1000.0	-0.025	-1000.0
HIF-2-alpha transcription factor network	14.0	634.0	43.0	-0.048	0.049	1000.0	-1000.0	-0.039	-1000.0
IL2 signaling events mediated by PI3K	14.0	830.0	58.0	-0.035	0.068	1000.0	-1000.0	-0.03	-1000.0
TCGA08_rtk_signaling	14.0	372.0	26.0	-0.015	0.049	1000.0	-1000.0	-0.007	-1000.0
Regulation of Androgen receptor activity	14.0	1017.0	70.0	-0.079	0.042	1000.0	-1000.0	-0.04	-1000.0
FOXA2 and FOXA3 transcription factor networks	13.0	635.0	46.0	-0.063	0.043	1000.0	-1000.0	-0.082	-1000.0
Retinoic acid receptors-mediated signaling	13.0	762.0	58.0	-0.042	0.05	1000.0	-1000.0	-0.028	-1000.0
IL2 signaling events mediated by STAT5	12.0	283.0	22.0	-0.013	0.047	1000.0	-1000.0	-0.025	-1000.0
LPA4-mediated signaling events	11.0	137.0	12.0	-0.03	0.021	1000.0	-1000.0	-0.018	-1000.0
IFN-gamma pathway	11.0	781.0	68.0	-0.022	0.073	1000.0	-1000.0	-0.039	-1000.0
Signaling events mediated by PRL	11.0	406.0	34.0	-0.036	0.046	1000.0	-1000.0	-0.032	-1000.0
Signaling events mediated by HDAC Class III	10.0	414.0	40.0	-0.07	0.051	1000.0	-1000.0	-0.038	-1000.0
Role of Calcineurin-dependent NFAT signaling in lymphocytes	10.0	845.0	83.0	-0.047	0.05	1000.0	-1000.0	-0.021	-1000.0
PDGFR-beta signaling pathway	10.0	990.0	97.0	-0.103	0.07	1000.0	-1000.0	-0.039	-1000.0
Syndecan-3-mediated signaling events	9.0	346.0	35.0	-0.022	0.073	1000.0	-1000.0	-0.014	-1000.0
HIV-1 Nef: Negative effector of Fas and TNF-alpha	9.0	425.0	45.0	-0.001	0.065	1000.0	-1000.0	-0.032	-1000.0
E-cadherin signaling in the nascent adherens junction	9.0	730.0	76.0	-0.018	0.057	1000.0	-1000.0	-0.036	-1000.0
E-cadherin signaling in keratinocytes	9.0	427.0	43.0	-0.015	0.046	1000.0	-1000.0	-0.012	-1000.0
Class I PI3K signaling events mediated by Akt	8.0	599.0	68.0	-0.033	0.05	1000.0	-1000.0	-0.023	-1000.0
FoxO family signaling	8.0	536.0	64.0	-0.023	0.058	1000.0	-1000.0	-0.049	-1000.0
Paxillin-dependent events mediated by a4b1	8.0	317.0	36.0	-0.047	0.048	1000.0	-1000.0	-0.028	-1000.0
p38 MAPK signaling pathway	8.0	357.0	44.0	-0.029	0.068	1000.0	-1000.0	-0.014	-1000.0
Atypical NF-kappaB pathway	7.0	220.0	31.0	-0.009	0.032	1000.0	-1000.0	-0.021	-1000.0
Regulation of Telomerase	7.0	760.0	102.0	-0.024	0.057	1000.0	-1000.0	-0.04	-1000.0
Canonical NF-kappaB pathway	6.0	264.0	39.0	-0.004	0.057	1000.0	-1000.0	-0.019	-1000.0
Class IB PI3K non-lipid kinase events	6.0	18.0	3.0	-0.028	0.028	1000.0	-1000.0	-0.019	-1000.0
Signaling mediated by p38-gamma and p38-delta	5.0	78.0	15.0	-0.016	0.029	1000.0	-1000.0	-0.023	-1000.0
PLK2 and PLK4 events	4.0	13.0	3.0	-0.013	0.027	1000.0	-1000.0	-0.019	-1000.0
Circadian rhythm pathway	4.0	96.0	22.0	-0.007	0.04	1000.0	-1000.0	-0.027	-1000.0
TRAIL signaling pathway	4.0	197.0	48.0	-0.01	0.049	1000.0	-1000.0	-0.025	-1000.0
Regulation of cytoplasmic and nuclear SMAD2/3 signaling	3.0	75.0	23.0	0.01	0.054	1000.0	-1000.0	-0.019	-1000.0
Signaling events mediated by HDAC Class II	3.0	251.0	75.0	-0.029	0.065	1000.0	-1000.0	-0.024	-1000.0
Insulin-mediated glucose transport	3.0	126.0	32.0	-0.013	0.046	1000.0	-1000.0	-0.02	-1000.0
Signaling events mediated by HDAC Class I	3.0	337.0	104.0	-0.052	0.064	1000.0	-1000.0	-0.036	-1000.0
Arf6 trafficking events	3.0	236.0	71.0	-0.047	0.05	1000.0	-1000.0	-0.035	-1000.0
Arf1 pathway	2.0	111.0	54.0	-0.006	0.048	1000.0	-1000.0	-0.012	-1000.0
Arf6 downstream pathway	1.0	58.0	43.0	-0.053	0.054	1000.0	-1000.0	-0.032	-1000.0
Sumoylation by RanBP2 regulates transcriptional repression	0.0	9.0	27.0	-0.011	0.06	1000.0	-1000.0	-0.027	-1000.0
E-cadherin signaling events	0.0	0.0	5.0	0.024	0.047	1000.0	-1000.0	0.023	-1000.0
Alternative NF-kappaB pathway	0.0	3.0	13.0	-0.0	0.071	1000.0	-1000.0	-0.0	-1000.0
Total	3050	181747	7203	-9.04179638688	7.53558580394	131000	-131000	-3.77268393647	-131000