Signaling events mediated by the Hedgehog family Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations TGFB2 0.032 0.08 -9999.0 0.0 -0.466 4.0 4.0 IHH 0.019 0.017 -9999.0 0.0 -9999.0 0.0 0.0 SHH Np/Cholesterol/GAS1 -0.153 0.224 -9999.0 0.0 -0.506 45.0 45.0 LRPAP1 0.012 0.0 -9999.0 0.0 -9999.0 0.0 0.0 dorsoventral neural tube patterning 0.152 0.223 0.502 45.0 -9999.0 0.0 45.0 SMO/beta Arrestin2 0.009 0.064 -9999.0 0.0 -9999.0 0.0 0.0 SMO 0.004 0.066 -9999.0 0.0 -9999.0 0.0 0.0 AKT1 0.018 0.042 -9999.0 0.0 -9999.0 0.0 0.0 ARRB2 0.012 0.0 -9999.0 0.0 -9999.0 0.0 0.0 BOC 0.012 0.003 -9999.0 0.0 -9999.0 0.0 0.0 ADRBK1 0.012 0.0 -9999.0 0.0 -9999.0 0.0 0.0 heart looping 0.004 0.065 -9999.0 0.0 -9999.0 0.0 0.0 STIL -0.084 0.19 -9999.0 0.0 -0.386 45.0 45.0 DHH N/PTCH2 0.014 0.047 -9999.0 0.0 -0.579 1.0 1.0 DHH N/PTCH1 0.033 0.042 -9999.0 0.0 -9999.0 0.0 0.0 PIK3CA 0.012 0.001 -9999.0 0.0 -9999.0 0.0 0.0 DHH 0.011 0.003 -9999.0 0.0 -9999.0 0.0 0.0 PTHLH 0.028 0.107 -9999.0 0.0 -0.642 4.0 4.0 determination of left/right symmetry 0.004 0.065 -9999.0 0.0 -9999.0 0.0 0.0 PIK3R1 0.012 0.0 -9999.0 0.0 -9999.0 0.0 0.0 skeletal system development 0.028 0.106 -9999.0 0.0 -0.636 4.0 4.0 IHH N/Hhip 0.006 0.054 -9999.0 0.0 -9999.0 0.0 0.0 DHH N/Hhip 0.003 0.046 -9999.0 0.0 -9999.0 0.0 0.0 mol:Cholesterol -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 heart development 0.004 0.065 -9999.0 0.0 -9999.0 0.0 0.0 pancreas development 0.011 0.004 -9999.0 0.0 -9999.0 0.0 0.0 HHAT 0.012 0.001 -9999.0 0.0 -9999.0 0.0 0.0 PI3K 0.017 0.012 -9999.0 0.0 -9999.0 0.0 0.0 EntrezGene:84976 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 GAS1 0.008 0.006 -9999.0 0.0 -9999.0 0.0 0.0 somite specification 0.004 0.065 -9999.0 0.0 -9999.0 0.0 0.0 SHH Np/Cholesterol/PTCH1 -0.09 0.2 -9999.0 0.0 -0.408 45.0 45.0 SHH Np/Cholesterol/PTCH2 -0.117 0.216 -9999.0 0.0 -0.46 46.0 46.0 SHH Np/Cholesterol/Megalin -0.165 0.26 -9999.0 0.0 -0.509 56.0 56.0 SHH -0.148 0.266 -9999.0 0.0 -0.58 45.0 45.0 catabolic process 0.03 0.047 -9999.0 0.0 -9999.0 0.0 0.0 SMO/Vitamin D3 -0.076 0.187 -9999.0 0.0 -0.373 45.0 45.0 SHH Np/Cholesterol/Hhip -0.125 0.211 -9999.0 0.0 -0.463 45.0 45.0 LRP2 -0.074 0.234 -9999.0 0.0 -0.759 17.0 17.0 receptor-mediated endocytosis -0.095 0.197 -9999.0 0.0 -0.549 8.0 8.0 SHH Np/Cholesterol/BOC -0.119 0.213 -9999.0 0.0 -0.46 45.0 45.0 SHH Np/Cholesterol/CDO -0.118 0.217 -9999.0 0.0 -0.467 45.0 45.0 mesenchymal cell differentiation 0.124 0.21 0.459 45.0 -9999.0 0.0 45.0 mol:Vitamin D3 -0.088 0.2 -9999.0 0.0 -0.406 45.0 45.0 IHH N/PTCH2 0.018 0.052 -9999.0 0.0 -0.627 1.0 1.0 CDON 0.012 0.002 -9999.0 0.0 -9999.0 0.0 0.0 IHH N/PTCH1 0.033 0.048 -9999.0 0.0 -9999.0 0.0 0.0 Megalin/LRPAP1 -0.048 0.181 -9999.0 0.0 -0.579 17.0 17.0 PTCH2 0.007 0.06 -9999.0 0.0 -0.759 1.0 1.0 SHH Np/Cholesterol -0.12 0.213 -9999.0 0.0 -0.465 45.0 45.0 PTCH1 0.03 0.047 -9999.0 0.0 -9999.0 0.0 0.0 HHIP 0.011 0.004 -9999.0 0.0 -9999.0 0.0 0.0