Nephrin/Neph1 signaling in the kidney podocyte Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations positive regulation of NF-kappaB transcription factor activity -0.023 0.067 0.224 10.0 -0.234 1.0 11.0 KIRREL 0.023 0.018 -9999.0 0.0 -9999.0 0.0 0.0 Nephrin/NEPH1Par3/Par6/Atypical PKCs 0.023 0.067 0.234 1.0 -0.224 10.0 11.0 PLCG1 0.015 0.013 -9999.0 0.0 -9999.0 0.0 0.0 ARRB2 0.023 0.009 -9999.0 0.0 -9999.0 0.0 0.0 WASL 0.025 0.005 -9999.0 0.0 -9999.0 0.0 0.0 Nephrin/NEPH1/podocin/CD2AP 0.043 0.073 0.227 1.0 -0.199 10.0 11.0 ChemicalAbstracts:57-88-5 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 Nephrin/NEPH1/podocin/NCK1-2/N-WASP 0.014 0.042 0.251 1.0 -0.213 2.0 3.0 FYN -0.017 0.061 0.218 5.0 -0.265 2.0 7.0 mol:Ca2+ 0.026 0.063 0.219 1.0 -0.214 6.0 7.0 mol:DAG 0.027 0.064 0.223 1.0 -0.215 6.0 7.0 NPHS2 -0.012 0.06 -9999.0 0.0 -0.356 4.0 4.0 mol:IP3 0.027 0.064 0.223 1.0 -0.215 6.0 7.0 regulation of endocytosis 0.031 0.058 0.206 1.0 -0.164 9.0 10.0 Nephrin/NEPH1/podocin/Cholesterol 0.03 0.065 0.209 1.0 -0.182 12.0 13.0 establishment of cell polarity 0.023 0.067 0.234 1.0 -0.224 10.0 11.0 Nephrin/NEPH1/podocin/NCK1-2 0.057 0.069 -9999.0 0.0 -0.184 10.0 10.0 Nephrin/NEPH1/beta Arrestin2 0.033 0.06 0.214 1.0 -0.165 9.0 10.0 NPHS1 0.011 0.085 0.328 2.0 -0.346 7.0 9.0 Nephrin/NEPH1/podocin 0.031 0.058 0.211 1.0 -0.164 11.0 12.0 TJP1 0.026 0.005 -9999.0 0.0 -9999.0 0.0 0.0 NCK1 0.027 0.0 -9999.0 0.0 -9999.0 0.0 0.0 NCK2 0.026 0.002 -9999.0 0.0 -9999.0 0.0 0.0 heterophilic cell adhesion -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 Nephrin/NEPH1/podocin/PLCgamma1 0.028 0.064 0.227 1.0 -0.215 6.0 7.0 CD2AP 0.026 0.004 -9999.0 0.0 -9999.0 0.0 0.0 Nephrin/NEPH1/podocin/GRB2 0.043 0.071 0.227 1.0 -0.199 10.0 11.0 GRB2 0.026 0.004 -9999.0 0.0 -9999.0 0.0 0.0 homophilic cell adhesion -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 TRPC6 -0.019 0.063 0.223 5.0 -0.182 9.0 14.0 cytoskeleton organization -0.008 0.048 0.226 2.0 -0.245 2.0 4.0 Nephrin/NEPH1 0.022 0.048 0.192 1.0 -0.149 10.0 11.0 Nephrin/NEPH1/ZO-1 0.036 0.06 0.222 1.0 -0.189 8.0 9.0