Signaling events mediated by the Hedgehog family Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations TGFB2 0.018 0.068 -9999.0 0.0 -0.394 4.0 4.0 IHH 0.03 0.022 -9999.0 0.0 -0.114 3.0 3.0 SHH Np/Cholesterol/GAS1 -0.075 0.108 -9999.0 0.0 -0.225 43.0 43.0 LRPAP1 0.026 0.005 -9999.0 0.0 -9999.0 0.0 0.0 dorsoventral neural tube patterning 0.075 0.108 0.223 43.0 -9999.0 0.0 43.0 SMO/beta Arrestin2 0.02 0.059 -9999.0 0.0 -9999.0 0.0 0.0 SMO 0.006 0.046 -9999.0 0.0 -0.273 3.0 3.0 AKT1 -0.0 0.097 -9999.0 0.0 -0.348 8.0 8.0 ARRB2 0.023 0.009 -9999.0 0.0 -9999.0 0.0 0.0 BOC 0.025 0.006 -9999.0 0.0 -9999.0 0.0 0.0 ADRBK1 0.026 0.004 -9999.0 0.0 -9999.0 0.0 0.0 heart looping 0.006 0.046 -9999.0 0.0 -0.27 3.0 3.0 STIL -0.023 0.097 0.204 10.0 -0.212 3.0 13.0 DHH N/PTCH2 0.036 0.023 -9999.0 0.0 -0.241 1.0 1.0 DHH N/PTCH1 0.036 0.042 -9999.0 0.0 -0.247 3.0 3.0 PIK3CA 0.026 0.002 -9999.0 0.0 -9999.0 0.0 0.0 DHH 0.023 0.011 -9999.0 0.0 -9999.0 0.0 0.0 PTHLH 0.01 0.102 -9999.0 0.0 -0.723 3.0 3.0 determination of left/right symmetry 0.006 0.046 -9999.0 0.0 -0.27 3.0 3.0 PIK3R1 0.025 0.006 -9999.0 0.0 -9999.0 0.0 0.0 skeletal system development 0.01 0.102 -9999.0 0.0 -0.716 3.0 3.0 IHH N/Hhip 0.021 0.062 -9999.0 0.0 -0.175 14.0 14.0 DHH N/Hhip 0.02 0.055 -9999.0 0.0 -0.155 14.0 14.0 mol:Cholesterol 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 heart development 0.006 0.046 -9999.0 0.0 -0.27 3.0 3.0 pancreas development 0.022 0.01 -9999.0 0.0 -9999.0 0.0 0.0 HHAT 0.026 0.004 -9999.0 0.0 -9999.0 0.0 0.0 PI3K 0.036 0.018 -9999.0 0.0 -0.154 1.0 1.0 EntrezGene:84976 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 GAS1 0.017 0.013 -9999.0 0.0 -9999.0 0.0 0.0 somite specification 0.006 0.046 -9999.0 0.0 -0.27 3.0 3.0 SHH Np/Cholesterol/PTCH1 -0.024 0.088 0.192 2.0 -0.219 3.0 5.0 SHH Np/Cholesterol/PTCH2 -0.031 0.095 0.19 2.0 -0.184 43.0 45.0 SHH Np/Cholesterol/Megalin -0.048 0.113 0.167 4.0 -0.204 51.0 55.0 SHH -0.065 0.119 0.375 3.0 -0.241 42.0 45.0 catabolic process 0.023 0.043 -9999.0 0.0 -0.274 3.0 3.0 SMO/Vitamin D3 -0.022 0.081 0.19 2.0 -0.25 3.0 5.0 SHH Np/Cholesterol/Hhip -0.042 0.096 0.19 2.0 -0.185 42.0 44.0 LRP2 -0.033 0.109 -9999.0 0.0 -0.343 17.0 17.0 receptor-mediated endocytosis -0.028 0.089 0.232 2.0 -0.28 3.0 5.0 SHH Np/Cholesterol/BOC -0.037 0.095 0.19 2.0 -0.184 43.0 45.0 SHH Np/Cholesterol/CDO -0.033 0.096 0.19 2.0 -0.185 43.0 45.0 mesenchymal cell differentiation 0.042 0.095 0.184 42.0 -0.188 2.0 44.0 mol:Vitamin D3 -0.018 0.1 0.209 9.0 -0.219 3.0 12.0 IHH N/PTCH2 0.038 0.029 -9999.0 0.0 -0.266 1.0 1.0 CDON 0.025 0.006 -9999.0 0.0 -9999.0 0.0 0.0 IHH N/PTCH1 0.033 0.045 -9999.0 0.0 -0.275 3.0 3.0 Megalin/LRPAP1 0.005 0.085 -9999.0 0.0 -0.241 17.0 17.0 PTCH2 0.024 0.029 -9999.0 0.0 -0.343 1.0 1.0 SHH Np/Cholesterol -0.038 0.085 -9999.0 0.0 -0.178 43.0 43.0 PTCH1 0.024 0.043 -9999.0 0.0 -0.275 3.0 3.0 HHIP 0.022 0.01 -9999.0 0.0 -9999.0 0.0 0.0