E-cadherin signaling in the nascent adherens junction Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations CTTN -0.248 0.286 -9999.0 0.0 -0.579 110.0 110.0 KLHL20 -0.074 0.084 -9999.0 0.0 -0.351 1.0 1.0 CYFIP2 -0.093 0.255 -9999.0 0.0 -0.796 30.0 30.0 Rac1/GDP -0.12 0.196 -9999.0 0.0 -0.385 4.0 4.0 ENAH -0.248 0.286 -9999.0 0.0 -0.579 110.0 110.0 AP1M1 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 RAP1B -0.003 0.028 -9999.0 0.0 -0.322 2.0 2.0 RAP1A 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 CTNNB1 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 CDC42/GTP -0.122 0.14 -9999.0 0.0 -0.37 2.0 2.0 ABI1/Sra1/Nap1 -0.064 0.077 -9999.0 0.0 -0.236 24.0 24.0 E-cadherin/beta catenin/alpha catenin/beta7/alphaE Integrin -0.207 0.235 -9999.0 0.0 -0.477 110.0 110.0 RAPGEF1 -0.182 0.263 -9999.0 0.0 -0.485 110.0 110.0 CTNND1 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 regulation of calcium-dependent cell-cell adhesion -0.258 0.298 -9999.0 0.0 -0.602 110.0 110.0 CRK -0.207 0.285 -9999.0 0.0 -0.535 110.0 110.0 E-cadherin/gamma catenin/alpha catenin -0.226 0.259 -9999.0 0.0 -0.525 110.0 110.0 alphaE/beta7 Integrin -0.002 0.018 -9999.0 0.0 -9999.0 0.0 0.0 IQGAP1 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 NCKAP1 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 Rap1/GTP/I-afadin -0.003 0.033 -9999.0 0.0 -0.484 1.0 1.0 DLG1 -0.248 0.286 -9999.0 0.0 -0.579 110.0 110.0 ChemicalAbstracts:7440-70-2 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 mol:PI-3-4-5-P3 -0.089 0.101 -9999.0 0.0 -0.259 1.0 1.0 MLLT4 -0.003 0.05 -9999.0 0.0 -0.796 1.0 1.0 ARF6/GTP/NME1/Tiam1 -0.005 0.026 -9999.0 0.0 -9999.0 0.0 0.0 PI3K -0.114 0.13 -9999.0 0.0 -0.342 1.0 1.0 ARF6 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 mol:Ca2+ 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/gamma catenin -0.262 0.3 -9999.0 0.0 -0.608 110.0 110.0 TIAM1 -0.01 0.056 -9999.0 0.0 -0.322 8.0 8.0 E-cadherin(dimer)/Ca2+ -0.195 0.224 -9999.0 0.0 -0.453 110.0 110.0 AKT1 -0.064 0.073 -9999.0 0.0 -9999.0 0.0 0.0 PIK3R1 -0.004 0.053 -9999.0 0.0 -0.559 2.0 2.0 CDH1 -0.343 0.393 -9999.0 0.0 -0.787 112.0 112.0 RhoA/GDP -0.12 0.196 -9999.0 0.0 -0.347 106.0 106.0 actin cytoskeleton organization -0.055 0.062 -9999.0 0.0 -0.245 1.0 1.0 CDC42/GDP -0.12 0.196 -9999.0 0.0 -0.395 3.0 3.0 E-cadherin/Ca2+/gamma catenin/alpha catenin/p120 catenin -0.146 0.168 -9999.0 0.0 -0.34 110.0 110.0 ITGB7 -0.003 0.028 -9999.0 0.0 -0.322 2.0 2.0 RAC1 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/beta catenin/alpha catenin/p120 catenin -0.205 0.236 -9999.0 0.0 -0.477 110.0 110.0 E-cadherin/Ca2+/beta catenin/alpha catenin -0.198 0.227 -9999.0 0.0 -0.46 110.0 110.0 mol:GDP -0.148 0.229 -9999.0 0.0 -0.412 110.0 110.0 CDC42/GTP/IQGAP1 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 JUP 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 p120 catenin/RhoA/GDP -0.151 0.174 -9999.0 0.0 -0.402 3.0 3.0 RAC1/GTP/IQGAP1 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 PIP5K1C/AP1M1 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 RHOA 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 CDC42 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 CTNNA1 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 positive regulation of S phase of mitotic cell cycle -0.035 0.042 -9999.0 0.0 -0.292 1.0 1.0 NME1 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 clathrin coat assembly -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 TJP1 -0.248 0.286 -9999.0 0.0 -0.579 110.0 110.0 regulation of cell-cell adhesion -0.107 0.123 -9999.0 0.0 -0.321 2.0 2.0 WASF2 -0.033 0.039 -9999.0 0.0 -0.141 1.0 1.0 Rap1/GTP -0.14 0.161 -9999.0 0.0 -0.43 2.0 2.0 E-cadherin/gamma catenin/alpha catenin/beta7/alphaE Integrin -0.193 0.22 -9999.0 0.0 -0.446 110.0 110.0 CCND1 -0.042 0.051 -9999.0 0.0 -0.375 1.0 1.0 VAV2 -0.197 0.275 -9999.0 0.0 -0.515 110.0 110.0 RAP1/GDP -0.143 0.164 -9999.0 0.0 -0.429 2.0 2.0 adherens junction assembly -0.239 0.276 -9999.0 0.0 -0.557 110.0 110.0 homophilic cell adhesion 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ABI1 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 PIP5K1C 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 regulation of heterotypic cell-cell adhesion -0.183 0.208 -9999.0 0.0 -0.423 110.0 110.0 E-cadherin/beta catenin -0.213 0.245 -9999.0 0.0 -0.495 110.0 110.0 mol:GTP 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 SRC -0.248 0.286 -9999.0 0.0 -0.579 110.0 110.0 PIK3CA 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 Rac1/GTP -0.116 0.135 -9999.0 0.0 -0.393 5.0 5.0 E-cadherin/beta catenin/alpha catenin -0.226 0.259 -9999.0 0.0 -0.525 110.0 110.0 ITGAE 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin -0.265 0.306 -9999.0 0.0 -0.618 110.0 110.0