Stabilization and expansion of the E-cadherin adherens junction Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations adherens junction organization -0.142 0.164 -9999.0 0.0 -0.331 110.0 110.0 epithelial cell differentiation -0.193 0.221 -9999.0 0.0 -0.448 110.0 110.0 CYFIP2 -0.093 0.255 -9999.0 0.0 -0.796 30.0 30.0 ENAH -0.078 0.157 -9999.0 0.0 -9999.0 0.0 0.0 EGFR -0.006 0.057 -9999.0 0.0 -0.48 3.0 3.0 EPHA2 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 MYO6 -0.183 0.21 -9999.0 0.0 -0.425 110.0 110.0 CTNNB1 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ABI1/Sra1/Nap1 -0.061 0.169 -9999.0 0.0 -0.525 30.0 30.0 AQP5 -0.178 0.208 -9999.0 0.0 -0.715 8.0 8.0 CTNND1 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 mol:PI-4-5-P2 -0.18 0.206 -9999.0 0.0 -0.418 110.0 110.0 regulation of calcium-dependent cell-cell adhesion -0.191 0.214 -9999.0 0.0 -0.425 115.0 115.0 EGF -0.316 0.389 -9999.0 0.0 -0.796 102.0 102.0 NCKAP1 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 AQP3 -0.303 0.309 -9999.0 0.0 -0.741 64.0 64.0 cortical microtubule organization -0.193 0.221 -9999.0 0.0 -0.448 110.0 110.0 GO:0000145 -0.171 0.197 -9999.0 0.0 -0.399 110.0 110.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin -0.195 0.224 -9999.0 0.0 -0.453 110.0 110.0 MLLT4 -0.003 0.05 -9999.0 0.0 -0.796 1.0 1.0 ARF6/GDP -0.15 0.173 -9999.0 0.0 -9999.0 0.0 0.0 ARF6 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 Ephrin A1/EPHA2/NCK1/GIT1 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 mol:Ca2+ 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 VASP -0.17 0.194 -9999.0 0.0 -0.393 110.0 110.0 PVRL2 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ZYX -0.183 0.21 -9999.0 0.0 -0.425 110.0 110.0 ARF6/GTP 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 CDH1 -0.343 0.393 -9999.0 0.0 -0.787 112.0 112.0 EGFR/EGFR/EGF/EGF -0.344 0.315 -9999.0 0.0 -0.562 157.0 157.0 RhoA/GDP -0.181 0.207 -9999.0 0.0 -0.42 110.0 110.0 actin cytoskeleton organization -0.173 0.198 -9999.0 0.0 -0.401 110.0 110.0 IGF-1R heterotetramer -0.011 0.087 -9999.0 0.0 -0.676 4.0 4.0 GIT1 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 IGF1R -0.011 0.088 -9999.0 0.0 -0.677 4.0 4.0 IGF1 -0.021 0.103 -9999.0 0.0 -0.441 12.0 12.0 DIAPH1 -0.102 0.248 -9999.0 0.0 -0.781 30.0 30.0 Wnt receptor signaling pathway 0.193 0.221 0.448 110.0 -9999.0 0.0 110.0 RHOA 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 RhoA/GTP -0.152 0.175 -9999.0 0.0 -9999.0 0.0 0.0 CTNNA1 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 VCL -0.177 0.203 -9999.0 0.0 -0.412 110.0 110.0 EFNA1 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 LPP -0.176 0.197 -9999.0 0.0 -0.402 110.0 110.0 Ephrin A1/EPHA2 -0.175 0.2 -9999.0 0.0 -0.406 110.0 110.0 SEC6/SEC8 -0.161 0.184 -9999.0 0.0 -9999.0 0.0 0.0 MGAT3 -0.195 0.218 -9999.0 0.0 -0.433 115.0 115.0 HGF/MET -0.199 0.22 -9999.0 0.0 -0.427 119.0 119.0 HGF -0.035 0.157 -9999.0 0.0 -0.686 13.0 13.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin/EPLIN -0.143 0.165 -9999.0 0.0 -0.334 110.0 110.0 actin cable formation -0.075 0.162 -9999.0 0.0 -0.331 23.0 23.0 KIAA1543 -0.35 0.306 -9999.0 0.0 -0.546 164.0 164.0 KIFC3 -0.184 0.213 -9999.0 0.0 -0.429 110.0 110.0 NCK1 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 EXOC3 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ACTN1 -0.183 0.21 -9999.0 0.0 -0.425 110.0 110.0 NCK1/GIT1 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 mol:GDP -0.193 0.221 -9999.0 0.0 -0.448 110.0 110.0 EXOC4 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 STX4 -0.183 0.21 -9999.0 0.0 -0.425 110.0 110.0 PIP5K1C -0.183 0.21 -9999.0 0.0 -0.425 110.0 110.0 LIMA1 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ABI1 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ROCK1 -0.133 0.152 -9999.0 0.0 -9999.0 0.0 0.0 adherens junction assembly -0.302 0.303 -9999.0 0.0 -0.74 58.0 58.0 IGF-1R heterotetramer/IGF1 -0.189 0.207 -9999.0 0.0 -0.518 9.0 9.0 nectin-2(dimer)/I-afadin/I-afadin/nectin-2(dimer/I-afadin/I-afadin -0.002 0.038 -9999.0 0.0 -0.608 1.0 1.0 MET -0.012 0.098 -9999.0 0.0 -0.796 4.0 4.0 PLEKHA7 -0.19 0.221 -9999.0 0.0 -0.437 111.0 111.0 mol:GTP 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 establishment of epithelial cell apical/basal polarity -0.154 0.175 -9999.0 0.0 -9999.0 0.0 0.0 cortical actin cytoskeleton stabilization -0.142 0.164 -9999.0 0.0 -0.331 110.0 110.0 regulation of cell-cell adhesion -0.173 0.198 -9999.0 0.0 -0.401 110.0 110.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin/EPLIN/cortical actin cytoskeleton -0.143 0.165 -9999.0 0.0 -0.334 110.0 110.0