E-cadherin signaling in the nascent adherens junction Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations CTTN -0.195 0.232 -9999.0 0.0 -0.459 104.0 104.0 KLHL20 -0.058 0.089 0.167 1.0 -0.255 4.0 5.0 CYFIP2 -0.042 0.175 -9999.0 0.0 -0.548 27.0 27.0 Rac1/GDP -0.112 0.139 -9999.0 0.0 -0.311 57.0 57.0 ENAH -0.195 0.232 -9999.0 0.0 -0.457 105.0 105.0 AP1M1 0.019 0.004 -9999.0 0.0 -9999.0 0.0 0.0 RAP1B 0.017 0.007 -9999.0 0.0 -9999.0 0.0 0.0 RAP1A 0.019 0.003 -9999.0 0.0 -9999.0 0.0 0.0 CTNNB1 0.019 0.003 -9999.0 0.0 -9999.0 0.0 0.0 CDC42/GTP -0.095 0.096 -9999.0 0.0 -0.259 2.0 2.0 ABI1/Sra1/Nap1 -0.063 0.064 -9999.0 0.0 -0.187 25.0 25.0 E-cadherin/beta catenin/alpha catenin/beta7/alphaE Integrin -0.101 0.178 -9999.0 0.0 -0.324 95.0 95.0 RAPGEF1 -0.171 0.202 -9999.0 0.0 -0.405 96.0 96.0 CTNND1 0.019 0.002 -9999.0 0.0 -9999.0 0.0 0.0 regulation of calcium-dependent cell-cell adhesion -0.201 0.237 -9999.0 0.0 -0.466 106.0 106.0 CRK -0.183 0.213 -9999.0 0.0 -0.425 104.0 104.0 E-cadherin/gamma catenin/alpha catenin -0.117 0.186 -9999.0 0.0 -0.351 95.0 95.0 alphaE/beta7 Integrin 0.027 0.017 -9999.0 0.0 -9999.0 0.0 0.0 IQGAP1 0.019 0.004 -9999.0 0.0 -9999.0 0.0 0.0 NCKAP1 0.019 0.002 -9999.0 0.0 -9999.0 0.0 0.0 Rap1/GTP/I-afadin 0.029 0.027 -9999.0 0.0 -0.32 1.0 1.0 DLG1 -0.197 0.232 -9999.0 0.0 -0.456 106.0 106.0 ChemicalAbstracts:7440-70-2 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 mol:PI-3-4-5-P3 -0.075 0.07 -9999.0 0.0 -0.194 2.0 2.0 MLLT4 0.016 0.036 -9999.0 0.0 -0.548 1.0 1.0 ARF6/GTP/NME1/Tiam1 0.036 0.023 -9999.0 0.0 -9999.0 0.0 0.0 PI3K -0.095 0.091 -9999.0 0.0 -0.249 2.0 2.0 ARF6 0.018 0.004 -9999.0 0.0 -9999.0 0.0 0.0 mol:Ca2+ 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/gamma catenin -0.148 0.211 -9999.0 0.0 -0.406 99.0 99.0 TIAM1 0.024 0.036 0.255 6.0 -9999.0 0.0 6.0 E-cadherin(dimer)/Ca2+ -0.097 0.166 -9999.0 0.0 -0.306 95.0 95.0 AKT1 -0.051 0.062 -9999.0 0.0 -9999.0 0.0 0.0 PIK3R1 0.02 0.015 0.255 1.0 -9999.0 0.0 1.0 CDH1 -0.206 0.278 0.255 2.0 -0.548 100.0 102.0 RhoA/GDP -0.118 0.145 -9999.0 0.0 -0.312 64.0 64.0 actin cytoskeleton organization -0.04 0.069 0.142 2.0 -0.184 4.0 6.0 CDC42/GDP -0.117 0.144 -9999.0 0.0 -0.312 62.0 62.0 E-cadherin/Ca2+/gamma catenin/alpha catenin/p120 catenin -0.102 0.134 -9999.0 0.0 -0.268 94.0 94.0 ITGB7 0.021 0.021 0.255 2.0 -9999.0 0.0 2.0 RAC1 0.018 0.006 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/beta catenin/alpha catenin/p120 catenin -0.102 0.177 -9999.0 0.0 -0.324 95.0 95.0 E-cadherin/Ca2+/beta catenin/alpha catenin -0.101 0.16 -9999.0 0.0 -0.301 96.0 96.0 mol:GDP -0.135 0.164 -9999.0 0.0 -0.357 66.0 66.0 CDC42/GTP/IQGAP1 0.024 0.008 -9999.0 0.0 -9999.0 0.0 0.0 JUP 0.019 0.002 -9999.0 0.0 -9999.0 0.0 0.0 p120 catenin/RhoA/GDP -0.112 0.155 -9999.0 0.0 -0.32 64.0 64.0 RAC1/GTP/IQGAP1 0.023 0.009 -9999.0 0.0 -9999.0 0.0 0.0 PIP5K1C/AP1M1 0.028 0.006 -9999.0 0.0 -9999.0 0.0 0.0 RHOA 0.019 0.004 -9999.0 0.0 -9999.0 0.0 0.0 CDC42 0.019 0.004 -9999.0 0.0 -9999.0 0.0 0.0 CTNNA1 0.019 0.003 -9999.0 0.0 -9999.0 0.0 0.0 positive regulation of S phase of mitotic cell cycle -0.026 0.053 0.182 3.0 -0.249 1.0 4.0 NME1 0.019 0.002 -9999.0 0.0 -9999.0 0.0 0.0 clathrin coat assembly -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 TJP1 -0.195 0.229 -9999.0 0.0 -0.452 105.0 105.0 regulation of cell-cell adhesion -0.084 0.085 -9999.0 0.0 -0.228 2.0 2.0 WASF2 -0.032 0.041 -9999.0 0.0 -0.126 2.0 2.0 Rap1/GTP -0.098 0.116 -9999.0 0.0 -0.285 3.0 3.0 E-cadherin/gamma catenin/alpha catenin/beta7/alphaE Integrin -0.089 0.172 -9999.0 0.0 -0.31 90.0 90.0 CCND1 -0.033 0.06 0.23 1.0 -0.314 1.0 2.0 VAV2 -0.188 0.233 -9999.0 0.0 -0.479 70.0 70.0 RAP1/GDP -0.1 0.128 0.218 2.0 -0.304 11.0 13.0 adherens junction assembly -0.189 0.222 -9999.0 0.0 -0.437 105.0 105.0 homophilic cell adhesion -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ABI1 0.018 0.004 -9999.0 0.0 -9999.0 0.0 0.0 PIP5K1C 0.019 0.003 -9999.0 0.0 -9999.0 0.0 0.0 regulation of heterotypic cell-cell adhesion -0.095 0.161 -9999.0 0.0 -0.302 90.0 90.0 E-cadherin/beta catenin -0.152 0.188 -9999.0 0.0 -0.368 107.0 107.0 mol:GTP 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 SRC -0.196 0.228 -9999.0 0.0 -0.448 106.0 106.0 PIK3CA 0.019 0.003 -9999.0 0.0 -9999.0 0.0 0.0 Rac1/GTP -0.102 0.126 0.299 1.0 -0.354 11.0 12.0 E-cadherin/beta catenin/alpha catenin -0.119 0.186 -9999.0 0.0 -0.351 96.0 96.0 ITGAE 0.018 0.005 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin -0.206 0.243 -9999.0 0.0 -0.477 106.0 106.0