Nephrin/Neph1 signaling in the kidney podocyte Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations positive regulation of NF-kappaB transcription factor activity 0.163 0.219 0.419 104.0 -9999.0 0.0 104.0 KIRREL -0.01 0.068 0.231 11.0 -9999.0 0.0 11.0 Nephrin/NEPH1Par3/Par6/Atypical PKCs -0.163 0.219 -9999.0 0.0 -0.42 104.0 104.0 PLCG1 0.018 0.004 -9999.0 0.0 -9999.0 0.0 0.0 ARRB2 0.018 0.005 -9999.0 0.0 -9999.0 0.0 0.0 WASL 0.018 0.005 -9999.0 0.0 -9999.0 0.0 0.0 Nephrin/NEPH1/podocin/CD2AP -0.134 0.205 -9999.0 0.0 -0.355 108.0 108.0 ChemicalAbstracts:57-88-5 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 Nephrin/NEPH1/podocin/NCK1-2/N-WASP -0.139 0.177 -9999.0 0.0 -0.327 108.0 108.0 FYN -0.143 0.186 0.251 5.0 -0.337 108.0 113.0 mol:Ca2+ -0.133 0.203 -9999.0 0.0 -0.354 107.0 107.0 mol:DAG -0.133 0.204 -9999.0 0.0 -0.355 107.0 107.0 NPHS2 -0.093 0.178 -9999.0 0.0 -0.578 29.0 29.0 mol:IP3 -0.133 0.204 -9999.0 0.0 -0.355 107.0 107.0 regulation of endocytosis -0.125 0.18 -9999.0 0.0 -0.322 106.0 106.0 Nephrin/NEPH1/podocin/Cholesterol -0.14 0.2 -9999.0 0.0 -0.35 111.0 111.0 establishment of cell polarity -0.163 0.219 -9999.0 0.0 -0.419 104.0 104.0 Nephrin/NEPH1/podocin/NCK1-2 -0.122 0.197 -9999.0 0.0 -0.33 111.0 111.0 Nephrin/NEPH1/beta Arrestin2 -0.126 0.184 -9999.0 0.0 -0.326 106.0 106.0 NPHS1 -0.243 0.273 -9999.0 0.0 -0.56 107.0 107.0 Nephrin/NEPH1/podocin -0.131 0.194 -9999.0 0.0 -0.339 108.0 108.0 TJP1 0.019 0.004 -9999.0 0.0 -9999.0 0.0 0.0 NCK1 0.019 0.002 -9999.0 0.0 -9999.0 0.0 0.0 NCK2 0.019 0.002 -9999.0 0.0 -9999.0 0.0 0.0 heterophilic cell adhesion 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 Nephrin/NEPH1/podocin/PLCgamma1 -0.134 0.206 -9999.0 0.0 -0.357 107.0 107.0 CD2AP 0.018 0.005 -9999.0 0.0 -9999.0 0.0 0.0 Nephrin/NEPH1/podocin/GRB2 -0.134 0.204 -9999.0 0.0 -0.353 109.0 109.0 GRB2 0.019 0.003 -9999.0 0.0 -9999.0 0.0 0.0 homophilic cell adhesion 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 TRPC6 -0.138 0.182 0.243 6.0 -0.323 110.0 116.0 cytoskeleton organization -0.18 0.209 -9999.0 0.0 -0.404 107.0 107.0 Nephrin/NEPH1 -0.113 0.157 -9999.0 0.0 -0.297 104.0 104.0 Nephrin/NEPH1/ZO-1 -0.124 0.182 -9999.0 0.0 -0.342 101.0 101.0