Stabilization and expansion of the E-cadherin adherens junction Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations adherens junction organization -0.103 0.131 -9999.0 0.0 -0.264 92.0 92.0 epithelial cell differentiation -0.099 0.163 -9999.0 0.0 -0.303 95.0 95.0 CYFIP2 -0.042 0.175 -9999.0 0.0 -0.548 27.0 27.0 ENAH -0.094 0.098 0.243 1.0 -9999.0 0.0 1.0 EGFR 0.016 0.039 0.255 1.0 -0.548 1.0 2.0 EPHA2 0.018 0.005 -9999.0 0.0 -9999.0 0.0 0.0 MYO6 -0.123 0.137 -9999.0 0.0 -0.295 95.0 95.0 CTNNB1 0.019 0.003 -9999.0 0.0 -9999.0 0.0 0.0 ABI1/Sra1/Nap1 -0.005 0.119 -9999.0 0.0 -0.351 26.0 26.0 AQP5 -0.115 0.151 -9999.0 0.0 -0.529 11.0 11.0 CTNND1 0.019 0.002 -9999.0 0.0 -9999.0 0.0 0.0 mol:PI-4-5-P2 -0.122 0.133 -9999.0 0.0 -0.291 93.0 93.0 regulation of calcium-dependent cell-cell adhesion -0.129 0.14 -9999.0 0.0 -0.296 99.0 99.0 EGF -0.209 0.274 -9999.0 0.0 -0.548 100.0 100.0 NCKAP1 0.019 0.002 -9999.0 0.0 -9999.0 0.0 0.0 AQP3 -0.218 0.235 -9999.0 0.0 -0.576 61.0 61.0 cortical microtubule organization -0.099 0.163 -9999.0 0.0 -0.303 95.0 95.0 GO:0000145 -0.117 0.127 -9999.0 0.0 -0.278 93.0 93.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin -0.097 0.166 -9999.0 0.0 -0.306 95.0 95.0 MLLT4 0.016 0.036 -9999.0 0.0 -0.548 1.0 1.0 ARF6/GDP -0.12 0.114 -9999.0 0.0 -0.276 85.0 85.0 ARF6 0.018 0.004 -9999.0 0.0 -9999.0 0.0 0.0 Ephrin A1/EPHA2/NCK1/GIT1 0.044 0.016 -9999.0 0.0 -9999.0 0.0 0.0 mol:Ca2+ 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 VASP -0.11 0.13 -9999.0 0.0 -0.277 88.0 88.0 PVRL2 0.018 0.005 -9999.0 0.0 -9999.0 0.0 0.0 ZYX -0.122 0.134 -9999.0 0.0 -0.295 91.0 91.0 ARF6/GTP 0.046 0.022 -9999.0 0.0 -9999.0 0.0 0.0 CDH1 -0.206 0.278 0.255 2.0 -0.548 100.0 102.0 EGFR/EGFR/EGF/EGF -0.202 0.214 -9999.0 0.0 -0.38 135.0 135.0 RhoA/GDP -0.094 0.158 -9999.0 0.0 -0.292 95.0 95.0 actin cytoskeleton organization -0.12 0.134 -9999.0 0.0 -0.291 94.0 94.0 IGF-1R heterotetramer 0.014 0.05 -9999.0 0.0 -0.547 2.0 2.0 GIT1 0.019 0.0 -9999.0 0.0 -9999.0 0.0 0.0 IGF1R 0.014 0.05 -9999.0 0.0 -0.548 2.0 2.0 IGF1 0.019 0.075 0.255 8.0 -0.548 3.0 11.0 DIAPH1 -0.078 0.246 -9999.0 0.0 -0.671 31.0 31.0 Wnt receptor signaling pathway 0.099 0.163 0.303 95.0 -9999.0 0.0 95.0 RHOA 0.019 0.004 -9999.0 0.0 -9999.0 0.0 0.0 RhoA/GTP -0.123 0.115 -9999.0 0.0 -0.278 86.0 86.0 CTNNA1 0.019 0.003 -9999.0 0.0 -9999.0 0.0 0.0 VCL -0.123 0.137 -9999.0 0.0 -0.297 94.0 94.0 EFNA1 0.018 0.004 -9999.0 0.0 -9999.0 0.0 0.0 LPP -0.118 0.131 -9999.0 0.0 -0.286 92.0 92.0 Ephrin A1/EPHA2 -0.094 0.149 -9999.0 0.0 -0.29 88.0 88.0 SEC6/SEC8 -0.109 0.114 -9999.0 0.0 -0.283 72.0 72.0 MGAT3 -0.13 0.142 -9999.0 0.0 -0.301 99.0 99.0 HGF/MET -0.103 0.159 -9999.0 0.0 -0.299 94.0 94.0 HGF -0.002 0.105 -9999.0 0.0 -0.548 9.0 9.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin/EPLIN -0.103 0.131 -9999.0 0.0 -0.266 92.0 92.0 actin cable formation -0.09 0.108 -9999.0 0.0 -0.295 19.0 19.0 KIAA1543 -0.122 0.134 -9999.0 0.0 -0.288 95.0 95.0 KIFC3 -0.123 0.139 -9999.0 0.0 -0.298 95.0 95.0 NCK1 0.019 0.002 -9999.0 0.0 -9999.0 0.0 0.0 EXOC3 0.017 0.007 -9999.0 0.0 -9999.0 0.0 0.0 ACTN1 -0.123 0.136 -9999.0 0.0 -0.295 94.0 94.0 NCK1/GIT1 0.029 0.004 -9999.0 0.0 -9999.0 0.0 0.0 mol:GDP -0.099 0.163 -9999.0 0.0 -0.303 95.0 95.0 EXOC4 0.018 0.005 -9999.0 0.0 -9999.0 0.0 0.0 STX4 -0.124 0.136 -9999.0 0.0 -0.295 95.0 95.0 PIP5K1C -0.124 0.135 -9999.0 0.0 -0.295 93.0 93.0 LIMA1 0.019 0.004 -9999.0 0.0 -9999.0 0.0 0.0 ABI1 0.018 0.004 -9999.0 0.0 -9999.0 0.0 0.0 ROCK1 -0.103 0.115 0.263 1.0 -9999.0 0.0 1.0 adherens junction assembly -0.126 0.14 -9999.0 0.0 -0.517 6.0 6.0 IGF-1R heterotetramer/IGF1 -0.094 0.151 -9999.0 0.0 -0.293 84.0 84.0 nectin-2(dimer)/I-afadin/I-afadin/nectin-2(dimer/I-afadin/I-afadin 0.024 0.029 -9999.0 0.0 -0.406 1.0 1.0 MET 0.012 0.061 -9999.0 0.0 -0.548 3.0 3.0 PLEKHA7 -0.128 0.141 -9999.0 0.0 -0.302 95.0 95.0 mol:GTP 0.043 0.016 -9999.0 0.0 -9999.0 0.0 0.0 establishment of epithelial cell apical/basal polarity -0.089 0.142 0.301 6.0 -9999.0 0.0 6.0 cortical actin cytoskeleton stabilization -0.103 0.131 -9999.0 0.0 -0.264 92.0 92.0 regulation of cell-cell adhesion -0.12 0.134 -9999.0 0.0 -0.291 94.0 94.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin/EPLIN/cortical actin cytoskeleton -0.103 0.131 -9999.0 0.0 -0.266 92.0 92.0