E-cadherin signaling in the nascent adherens junction Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations CTTN -0.089 0.196 -9999.0 0.0 -0.397 100.0 100.0 KLHL20 -0.012 0.097 0.21 7.0 -0.213 25.0 32.0 CYFIP2 0.015 0.09 -9999.0 0.0 -0.417 15.0 15.0 Rac1/GDP -0.032 0.126 0.255 1.0 -0.247 73.0 74.0 ENAH -0.085 0.19 -9999.0 0.0 -0.388 97.0 97.0 AP1M1 0.035 0.004 -9999.0 0.0 -9999.0 0.0 0.0 RAP1B 0.034 0.007 -9999.0 0.0 -9999.0 0.0 0.0 RAP1A 0.034 0.007 -9999.0 0.0 -9999.0 0.0 0.0 CTNNB1 0.035 0.005 -9999.0 0.0 -9999.0 0.0 0.0 CDC42/GTP -0.011 0.092 -9999.0 0.0 -0.214 1.0 1.0 ABI1/Sra1/Nap1 -0.036 0.051 -9999.0 0.0 -0.149 31.0 31.0 E-cadherin/beta catenin/alpha catenin/beta7/alphaE Integrin -0.033 0.162 -9999.0 0.0 -0.25 123.0 123.0 RAPGEF1 -0.067 0.172 0.239 3.0 -0.354 88.0 91.0 CTNND1 0.035 0.005 -9999.0 0.0 -9999.0 0.0 0.0 regulation of calcium-dependent cell-cell adhesion -0.086 0.206 -9999.0 0.0 -0.409 101.0 101.0 CRK -0.076 0.184 -9999.0 0.0 -0.38 90.0 90.0 E-cadherin/gamma catenin/alpha catenin -0.017 0.136 -9999.0 0.0 -0.249 91.0 91.0 alphaE/beta7 Integrin 0.004 0.116 -9999.0 0.0 -0.292 48.0 48.0 IQGAP1 0.034 0.006 -9999.0 0.0 -9999.0 0.0 0.0 NCKAP1 0.035 0.003 -9999.0 0.0 -9999.0 0.0 0.0 Rap1/GTP/I-afadin 0.051 0.031 -9999.0 0.0 -9999.0 0.0 0.0 DLG1 -0.088 0.197 -9999.0 0.0 -0.403 99.0 99.0 ChemicalAbstracts:7440-70-2 -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 mol:PI-3-4-5-P3 -0.024 0.058 -9999.0 0.0 -0.143 4.0 4.0 MLLT4 0.029 0.014 -9999.0 0.0 -9999.0 0.0 0.0 ARF6/GTP/NME1/Tiam1 0.047 0.069 -9999.0 0.0 -0.224 21.0 21.0 PI3K -0.026 0.076 -9999.0 0.0 -0.206 1.0 1.0 ARF6 0.035 0.005 -9999.0 0.0 -9999.0 0.0 0.0 mol:Ca2+ 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/gamma catenin -0.04 0.149 -9999.0 0.0 -0.295 92.0 92.0 TIAM1 0.008 0.105 -9999.0 0.0 -0.417 21.0 21.0 E-cadherin(dimer)/Ca2+ 0.001 0.126 -9999.0 0.0 -0.212 91.0 91.0 AKT1 -0.007 0.056 0.156 4.0 -9999.0 0.0 4.0 PIK3R1 0.034 0.007 -9999.0 0.0 -9999.0 0.0 0.0 CDH1 -0.08 0.196 -9999.0 0.0 -0.417 92.0 92.0 RhoA/GDP -0.027 0.135 0.282 4.0 -0.247 77.0 81.0 actin cytoskeleton organization -0.007 0.075 0.172 9.0 -0.156 25.0 34.0 CDC42/GDP -0.029 0.135 0.282 4.0 -0.247 77.0 81.0 E-cadherin/Ca2+/gamma catenin/alpha catenin/p120 catenin -0.036 0.105 -9999.0 0.0 -0.213 93.0 93.0 ITGB7 -0.026 0.154 -9999.0 0.0 -0.417 49.0 49.0 RAC1 0.031 0.012 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/beta catenin/alpha catenin/p120 catenin 0.002 0.135 -9999.0 0.0 -0.226 91.0 91.0 E-cadherin/Ca2+/beta catenin/alpha catenin -0.012 0.116 -9999.0 0.0 -0.21 91.0 91.0 mol:GDP -0.048 0.143 0.284 4.0 -0.281 78.0 82.0 CDC42/GTP/IQGAP1 0.045 0.011 -9999.0 0.0 -9999.0 0.0 0.0 JUP 0.034 0.008 -9999.0 0.0 -9999.0 0.0 0.0 p120 catenin/RhoA/GDP -0.02 0.14 0.272 3.0 -0.253 76.0 79.0 RAC1/GTP/IQGAP1 0.041 0.017 -9999.0 0.0 -9999.0 0.0 0.0 PIP5K1C/AP1M1 0.052 0.007 -9999.0 0.0 -9999.0 0.0 0.0 RHOA 0.035 0.005 -9999.0 0.0 -9999.0 0.0 0.0 CDC42 0.035 0.005 -9999.0 0.0 -9999.0 0.0 0.0 CTNNA1 0.033 0.008 -9999.0 0.0 -9999.0 0.0 0.0 positive regulation of S phase of mitotic cell cycle 0.001 0.056 0.138 13.0 -0.104 24.0 37.0 NME1 0.034 0.006 -9999.0 0.0 -9999.0 0.0 0.0 clathrin coat assembly -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 TJP1 -0.089 0.197 -9999.0 0.0 -0.403 99.0 99.0 regulation of cell-cell adhesion -0.018 0.075 -9999.0 0.0 -0.164 6.0 6.0 WASF2 -0.004 0.043 0.102 5.0 -0.09 15.0 20.0 Rap1/GTP -0.013 0.101 -9999.0 0.0 -0.237 1.0 1.0 E-cadherin/gamma catenin/alpha catenin/beta7/alphaE Integrin -0.022 0.16 -9999.0 0.0 -0.234 124.0 124.0 CCND1 0.001 0.066 0.161 12.0 -0.126 24.0 36.0 VAV2 -0.092 0.244 0.366 1.0 -0.45 97.0 98.0 RAP1/GDP -0.011 0.117 0.298 3.0 -0.237 6.0 9.0 adherens junction assembly -0.086 0.192 -9999.0 0.0 -0.391 99.0 99.0 homophilic cell adhesion 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ABI1 0.032 0.01 -9999.0 0.0 -9999.0 0.0 0.0 PIP5K1C 0.035 0.004 -9999.0 0.0 -9999.0 0.0 0.0 regulation of heterotypic cell-cell adhesion -0.029 0.148 -9999.0 0.0 -0.226 123.0 123.0 E-cadherin/beta catenin -0.069 0.144 -9999.0 0.0 -0.31 95.0 95.0 mol:GTP 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 SRC -0.086 0.192 -9999.0 0.0 -0.391 98.0 98.0 PIK3CA 0.034 0.006 -9999.0 0.0 -9999.0 0.0 0.0 Rac1/GTP -0.058 0.123 -9999.0 0.0 -0.349 27.0 27.0 E-cadherin/beta catenin/alpha catenin -0.016 0.136 -9999.0 0.0 -0.249 91.0 91.0 ITGAE 0.033 0.009 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin -0.088 0.21 -9999.0 0.0 -0.418 101.0 101.0