Signaling events mediated by the Hedgehog family Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations TGFB2 0.035 0.062 -9999.0 0.0 -0.433 4.0 4.0 IHH 0.043 0.033 -9999.0 0.0 -0.159 4.0 4.0 SHH Np/Cholesterol/GAS1 0.023 0.014 -9999.0 0.0 -9999.0 0.0 0.0 LRPAP1 0.034 0.008 -9999.0 0.0 -9999.0 0.0 0.0 dorsoventral neural tube patterning -0.022 0.014 -9999.0 0.0 -9999.0 0.0 0.0 SMO/beta Arrestin2 0.057 0.083 -9999.0 0.0 -0.373 4.0 4.0 SMO 0.027 0.07 -9999.0 0.0 -0.389 4.0 4.0 AKT1 0.032 0.08 -9999.0 0.0 -0.371 6.0 6.0 ARRB2 0.033 0.009 -9999.0 0.0 -9999.0 0.0 0.0 BOC 0.034 0.007 -9999.0 0.0 -9999.0 0.0 0.0 ADRBK1 0.034 0.007 -9999.0 0.0 -9999.0 0.0 0.0 heart looping 0.027 0.069 -9999.0 0.0 -0.384 4.0 4.0 STIL 0.046 0.077 0.359 5.0 -0.302 2.0 7.0 DHH N/PTCH2 0.035 0.064 -9999.0 0.0 -0.295 12.0 12.0 DHH N/PTCH1 0.039 0.074 -9999.0 0.0 -0.327 7.0 7.0 PIK3CA 0.034 0.006 -9999.0 0.0 -9999.0 0.0 0.0 DHH 0.019 0.077 -9999.0 0.0 -0.417 11.0 11.0 PTHLH 0.026 0.099 -9999.0 0.0 -0.669 6.0 6.0 determination of left/right symmetry 0.027 0.069 -9999.0 0.0 -0.384 4.0 4.0 PIK3R1 0.034 0.007 -9999.0 0.0 -9999.0 0.0 0.0 skeletal system development 0.026 0.098 -9999.0 0.0 -0.663 6.0 6.0 IHH N/Hhip 0.04 0.023 -9999.0 0.0 -9999.0 0.0 0.0 DHH N/Hhip 0.025 0.059 -9999.0 0.0 -0.301 11.0 11.0 mol:Cholesterol 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 heart development 0.027 0.069 -9999.0 0.0 -0.384 4.0 4.0 pancreas development 0.017 0.002 -9999.0 0.0 -9999.0 0.0 0.0 HHAT 0.03 0.026 -9999.0 0.0 -0.417 1.0 1.0 PI3K 0.049 0.014 -9999.0 0.0 -9999.0 0.0 0.0 EntrezGene:84976 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 GAS1 0.032 0.025 -9999.0 0.0 -0.417 1.0 1.0 somite specification 0.027 0.069 -9999.0 0.0 -0.384 4.0 4.0 SHH Np/Cholesterol/PTCH1 0.027 0.04 -9999.0 0.0 -0.315 2.0 2.0 SHH Np/Cholesterol/PTCH2 0.023 0.019 -9999.0 0.0 -0.23 1.0 1.0 SHH Np/Cholesterol/Megalin -0.086 0.124 -9999.0 0.0 -0.229 156.0 156.0 SHH -0.01 0.005 -9999.0 0.0 -9999.0 0.0 0.0 catabolic process 0.034 0.062 -9999.0 0.0 -0.416 6.0 6.0 SMO/Vitamin D3 0.036 0.064 -9999.0 0.0 -0.282 4.0 4.0 SHH Np/Cholesterol/Hhip 0.015 0.008 -9999.0 0.0 -9999.0 0.0 0.0 LRP2 -0.203 0.225 -9999.0 0.0 -0.417 192.0 192.0 receptor-mediated endocytosis -0.058 0.116 -9999.0 0.0 -0.387 10.0 10.0 SHH Np/Cholesterol/BOC 0.024 0.014 -9999.0 0.0 -9999.0 0.0 0.0 SHH Np/Cholesterol/CDO 0.023 0.014 -9999.0 0.0 -9999.0 0.0 0.0 mesenchymal cell differentiation -0.015 0.008 -9999.0 0.0 -9999.0 0.0 0.0 mol:Vitamin D3 0.058 0.083 0.385 6.0 -0.316 2.0 8.0 IHH N/PTCH2 0.051 0.033 -9999.0 0.0 -0.324 1.0 1.0 CDON 0.032 0.011 -9999.0 0.0 -9999.0 0.0 0.0 IHH N/PTCH1 0.043 0.067 -9999.0 0.0 -0.418 6.0 6.0 Megalin/LRPAP1 -0.13 0.171 -9999.0 0.0 -0.295 189.0 189.0 PTCH2 0.033 0.024 -9999.0 0.0 -0.417 1.0 1.0 SHH Np/Cholesterol 0.015 0.007 -9999.0 0.0 -9999.0 0.0 0.0 PTCH1 0.034 0.063 -9999.0 0.0 -0.417 6.0 6.0 HHIP 0.017 0.002 -9999.0 0.0 -9999.0 0.0 0.0