rank geneset description genes N_genes mut_tally N n npat nsite nsil n1 n2 n3 n4 n5 n6 p_ns_s p q 1 HSA00472_D_ARGININE_AND_D_ORNITHINE_METABOLISM Genes involved in D-arginine and D-ornithine metabolism DAO 1 DAO(11) 293722 11 11 11 2 8 1 1 1 0 0 0.0878 0.0862 1.000 2 HSA00627_1,4_DICHLOROBENZENE_DEGRADATION Genes involved in 1,4-dichlorobenzene degradation CMBL 1 CMBL(5) 210423 5 5 5 1 5 0 0 0 0 0 0.373 0.359 1.000 3 HSA00401_NOVOBIOCIN_BIOSYNTHESIS Genes involved in novobiocin biosynthesis GOT1, GOT2, TAT 3 GOT1(6), GOT2(6), TAT(19) 1077313 31 20 30 7 23 3 2 1 2 0 0.00611 0.839 1.000 4 BOTULINPATHWAY Blockade of Neurotransmitter Relase by Botulinum Toxin CHRM1, CHRNA1, SNAP25, STX1A, VAMP2 5 CHRM1(5), CHRNA1(7), SNAP25(8) 1337968 20 18 18 3 15 1 0 1 3 0 0.00173 0.954 1.000 5 FOSBPATHWAY FOSB gene expression and drug abuse CDK5, FOSB, GRIA2, JUND, PPP1R1B 5 CDK5(6), FOSB(5), GRIA2(41), JUND(1), PPP1R1B(2) 1504102 55 47 52 19 33 3 2 8 9 0 0.0695 0.955 1.000 6 HSA00031_INOSITOL_METABOLISM Genes involved in inositol metabolism ALDH6A1, TPI1 2 ALDH6A1(4), TPI1(1) 678404 5 5 4 1 3 0 0 2 0 0 0.339 0.972 1.000 7 SLRPPATHWAY Small leucine-rich proteoglycans (SLRPs) interact with and reorganize collagen fibers in the extracellular matrix. BGN, DCN, DSPG3, FMOD, KERA, LUM 5 BGN(7), DCN(18), FMOD(6), KERA(15), LUM(12) 1447420 58 44 54 22 45 4 3 3 3 0 0.0103 0.979 1.000 8 1_AND_2_METHYLNAPHTHALENE_DEGRADATION ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1 7 ADH1A(17), ADH1B(30), ADH1C(1), ADH4(10), ADH6(14), ADH7(16), ADHFE1(6) 2308177 94 70 77 29 76 4 4 6 4 0 0.00260 0.984 1.000 9 HSA00785_LIPOIC_ACID_METABOLISM Genes involved in lipoic acid metabolism LIAS, LIPT1, LOC387787 2 LIAS(2), LIPT1(1) 632316 3 2 3 0 0 2 0 0 1 0 0.394 0.991 1.000 10 TERCPATHWAY hTERC, the RNA subunit of telomerase, and hTERT, the catalytic protein subunit, are required for telomerase activity and are overexpressed in many cancers. NFYA, NFYB, NFYC, RB1, SP1, SP3 6 NFYA(1), NFYB(2), NFYC(2), RB1(10), SP1(5), SP3(1) 2727826 21 19 21 4 4 2 2 5 6 2 0.137 0.991 1.000 11 TCRMOLECULE T Cell Receptor and CD3 Complex CD3D, CD3E, CD3G, CD3Z, TRA@, TRB@ 3 CD3D(7), CD3E(2), CD3G(1) 459732 10 7 10 4 8 0 0 0 2 0 0.405 0.992 1.000 12 INOSITOL_METABOLISM ALDH6A1, ALDOA, ALDOB, ALDOC, TPI1 5 ALDH6A1(4), ALDOA(2), ALDOB(14), ALDOC(4), TPI1(1) 1615518 25 20 22 6 18 2 0 2 3 0 0.0130 0.994 1.000 13 NEUROTRANSMITTERSPATHWAY Biosynthesis of neurotransmitters DBH, GAD1, HDC, PNMT, TH, TPH1 6 DBH(15), GAD1(13), HDC(24), PNMT(4), TH(12), TPH1(12) 2438631 80 60 76 28 61 4 3 2 10 0 0.000490 0.995 1.000 14 IL18PATHWAY Pro-inflammatory IL-18 is activated in macrophages by caspase-1 cleavage and, in conjunction with IL-12, stimulates Th1 cell differentiation. CASP1, IFNG, IL12A, IL12B, IL18, IL2 6 CASP1(10), IFNG(4), IL12A(4), IL12B(3), IL18(3), IL2(4) 1200252 28 18 27 9 20 2 0 1 5 0 0.0680 0.998 1.000 15 SA_FAS_SIGNALING The TNF-type receptor Fas induces apoptosis on ligand binding. BCL2, CASP3, CASP8, CFL1, CFLAR, P11, PDE6D, TNFRSF6, TNFSF6 6 BCL2(2), CASP3(2), CASP8(9), CFL1(2), CFLAR(4), PDE6D(2) 1599493 21 19 20 7 10 1 2 5 3 0 0.348 1.000 1.000 16 PEPIPATHWAY Proepithelin (PEPI) induces epithelial cells to secrete IL-8, which promotes elastase secretion by neutrophils. ELA1, ELA2, ELA2A, ELA2B, ELA3B, GRN, IL8, SLPI 3 GRN(6), IL8(1), SLPI(6) 704069 13 13 13 7 6 1 0 5 1 0 0.688 1.000 1.000 17 HSA03060_PROTEIN_EXPORT Genes involved in protein export OXA1L, SEC61A2, SRP19, SRP54, SRP68, SRP72, SRP9, SRPR 8 OXA1L(8), SEC61A2(4), SRP19(1), SRP54(4), SRP68(7), SRP72(1), SRP9(1), SRPR(4) 3125500 30 27 25 7 14 0 1 7 8 0 0.139 1.000 1.000 18 BETAOXIDATIONPATHWAY Beta-Oxidation of Fatty Acids ACADL, ACADM, ACADS, ACAT1, ECHS1, HADHA 6 ACADL(5), ACADM(4), ACADS(5), ECHS1(3), HADHA(6) 2238420 23 22 23 6 14 4 1 3 1 0 0.136 1.000 1.000 19 HSA00830_RETINOL_METABOLISM Genes involved in retinol metabolism ALDH1A1, ALDH1A2, BCMO1, RDH5 4 ALDH1A1(5), ALDH1A2(14), BCMO1(15), RDH5(3) 1600078 37 33 32 13 25 2 1 4 5 0 0.0471 1.000 1.000 20 CDK5PATHWAY Cdk5, a regulatory kinase implicated in neuronal development, represses Mek1, which downregulates the MAP kinase pathway. CDK5, CDK5R1, DPM2, EGR1, HRAS, KLK2, MAP2K1, MAP2K2, MAPK1, MAPK3, NGFB, NGFR, RAF1 12 CDK5(6), CDK5R1(1), DPM2(1), EGR1(4), HRAS(3), KLK2(5), MAP2K1(14), MAP2K2(5), MAPK1(4), MAPK3(4), NGFR(8), RAF1(10) 3321423 65 54 57 26 31 7 3 14 10 0 0.0731 1.000 1.000 21 PKCPATHWAY Gq-coupled receptors promote hydrolysis of PIP2 to DAG and IP3, which causes calcium influx and activates protein kinase C. GNAQ, NFKB1, NFKBIA, PLCB1, PRKCA, PRKCB1, RELA 6 GNAQ(6), NFKB1(6), NFKBIA(2), PLCB1(54), PRKCA(8), RELA(4) 3348848 80 59 72 28 59 3 3 8 7 0 0.0380 1.000 1.000 22 SYNTHESIS_AND_DEGRADATION_OF_KETONE_BODIES ACAT1, ACAT2, BDH, HMGCL, OXCT1 4 ACAT2(1), HMGCL(4), OXCT1(4) 1377550 9 9 9 5 6 0 0 1 2 0 0.721 1.000 1.000 23 ST_PAC1_RECEPTOR_PATHWAY The signaling peptide PACAP binds to its receptor, PAC1R, which activates adenylyl cyclase and phospholipase C. ASAH1, CAMP, DAG1, GAS, GNAQ, ITPKA, ITPKB, PACAP 6 CAMP(2), DAG1(9), GNAQ(6), ITPKB(11) 2455502 28 24 26 10 20 0 2 2 4 0 0.0790 1.000 1.000 24 BBCELLPATHWAY Fas ligand expression by T cells induces apoptosis in Fas-expressing, inactive B cells. CD28, CD4, HLA-DRA, HLA-DRB1, TNFRSF5, TNFRSF6, TNFSF5, TNFSF6 4 CD28(2), CD4(8), HLA-DRA(12) 963847 22 21 20 11 18 1 0 1 2 0 0.188 1.000 1.000 25 IFNGPATHWAY IFN gamma signaling pathway IFNG, IFNGR1, IFNGR2, JAK1, JAK2, STAT1 6 IFNG(4), IFNGR1(3), IFNGR2(4), JAK1(6), JAK2(8), STAT1(5) 3333652 30 22 28 9 13 1 1 6 9 0 0.362 1.000 1.000 26 TERTPATHWAY hTERC, the RNA subunit of telomerase, and hTERT, the catalytic protein subunit, are required for telomerase activity and are overexpressed in many cancers. HDAC1, MAX, MYC, SP1, SP3, TP53, WT1, ZNF42 6 HDAC1(2), MYC(5), SP1(5), SP3(1), WT1(8) 2566628 21 19 20 5 10 3 3 2 3 0 0.107 1.000 1.000 27 EOSINOPHILSPATHWAY Recruitment of eosinophils in the inflammatory response observed in asthma occurs via the chemoattractant eotaxin binding to the CCR3 receptor. CCL11, CCL5, CCR3, CSF2, HLA-DRA, HLA-DRB1, IL3, IL5 8 CCL11(3), CCR3(10), CSF2(2), HLA-DRA(12), IL3(3), IL5(4) 1240919 34 25 32 16 28 1 0 2 3 0 0.0550 1.000 1.000 28 SA_REG_CASCADE_OF_CYCLIN_EXPR Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases. CCNA1, CCNA2, CCND1, CCNE1, CCNE2, CDK2, CDK4, CDKN1B, CDKN2A, E2F1, E2F2, E2F4, PRB1 11 CCNA1(14), CCND1(2), CCNE1(4), CCNE2(8), CDK4(7), CDKN1B(1), E2F1(5), E2F2(5), E2F4(3) 3164694 49 43 45 17 30 1 2 12 4 0 0.123 1.000 1.000 29 RABPATHWAY Rab family GTPases regulate vesicle transport, endocytosis and exocytosis, and vesicle docking via interactions with the rabphilins. ACTA1, MEL, RAB11A, RAB1A, RAB2, RAB27A, RAB3A, RAB4A, RAB5A, RAB6A, RAB7, RAB9A 9 ACTA1(4), RAB1A(2), RAB27A(3), RAB3A(4), RAB4A(1), RAB5A(2) 1721287 16 14 15 7 13 1 0 1 1 0 0.352 1.000 1.000 30 SULFUR_METABOLISM BPNT1, PAPSS1, PAPSS2, SULT1A2, SULT1A3, SULT1A3, SULT1A4, SULT1E1, SULT2A1, SUOX 7 PAPSS1(4), PAPSS2(5), SULT1A2(2), SULT1E1(16), SULT2A1(9), SUOX(4) 2495851 40 25 38 11 28 1 0 4 7 0 0.0329 1.000 1.000 31 VALINE_LEUCINE_AND_ISOLEUCINE_BIOSYNTHESIS BCAT1, IARS, LARS, LARS2, PDHA1, PDHA2, PDHB 7 BCAT1(13), IARS(8), LARS(12), LARS2(5), PDHA1(4), PDHA2(20), PDHB(1) 4110018 63 48 60 16 40 7 2 7 7 0 0.0207 1.000 1.000 32 HSA00471_D_GLUTAMINE_AND_D_GLUTAMATE_METABOLISM Genes involved in D-glutamine and D-glutamate metabolism GLS, GLS2, GLUD1, GLUD2 4 GLS(2), GLS2(3), GLUD1(2), GLUD2(4) 1859689 11 9 11 8 3 3 1 1 3 0 0.868 1.000 1.000 33 HSA00460_CYANOAMINO_ACID_METABOLISM Genes involved in cyanoamino acid metabolism ASRGL1, GBA, GBA3, GGT1, GGTL3, GGTL4, SHMT1, SHMT2 6 ASRGL1(6), GBA(7), GBA3(19), GGT1(8), SHMT1(2), SHMT2(3) 2190568 45 35 41 18 30 6 0 5 4 0 0.0575 1.000 1.000 34 HSA00130_UBIQUINONE_BIOSYNTHESIS Genes involved in ubiquinone biosynthesis COQ2, COQ3, COQ5, COQ6, COQ7, ND1, ND2, ND3, ND4, ND4L, ND5, ND6, NDUFA12, NDUFA13, NDUFB11 8 COQ2(2), COQ3(2), COQ5(2), COQ6(2), COQ7(3) 1626657 11 11 11 5 8 1 1 0 1 0 0.553 1.000 1.000 35 SA_PROGRAMMED_CELL_DEATH Programmed cell death, or apoptosis, eliminates damaged or unneeded cells. APAF1, BAD, BAK1, BAX, BCL10, BCL2, BCL2L1, BCL2L11, BID, CASP8AP2, CASP9, CES1 12 APAF1(6), BAK1(1), BAX(3), BCL10(3), BCL2(2), BCL2L11(5), CASP8AP2(10), CASP9(2), CES1(21) 4385703 53 38 51 13 34 6 2 4 7 0 0.0249 1.000 1.000 36 FXRPATHWAY The nuclear receptor transcription factors FXR and LXR are activated by cholesterol metabolites and regulate cholesterol homeostasis. FABP6, LDLR, NR0B2, NR1H3, NR1H4, RXRA 6 LDLR(17), NR0B2(6), NR1H3(3), NR1H4(14), RXRA(4) 2224107 44 31 44 16 28 7 3 4 2 0 0.0301 1.000 1.000 37 RIBOFLAVIN_METABOLISM ACP1, ACP2, ACP5, ACPP, ACPT, ENPP1, ENPP3, FLAD1, RFK, TYR 10 ACP1(4), ACP2(2), ACP5(3), ACPP(9), ACPT(3), ENPP1(13), ENPP3(13), FLAD1(10), TYR(9) 3953499 66 48 63 19 44 4 2 3 13 0 0.0144 1.000 1.000 38 CYANOAMINO_ACID_METABOLISM ATP6V0C, SHMT1, GBA3, GGT1, SHMT1, SHMT2 5 GBA3(19), GGT1(8), SHMT1(2), SHMT2(3) 1660403 32 28 29 17 21 4 0 4 3 0 0.246 1.000 1.000 39 PLCDPATHWAY Phospholipase C (PLC-d1) hydrolyzes the membrane lipid PIP2 to DAG and IP3, which induce calcium influx and activates protein kinase C. ADRA1B, PLCD1, PRKCA, PRKCB1, TGM2 4 ADRA1B(4), PLCD1(4), PRKCA(8), TGM2(10) 2034579 26 20 25 11 18 3 1 0 4 0 0.0518 1.000 1.000 40 FBW7PATHWAY Cyclin E interacts with cell cycle checkpoint kinase cdk2 to allow transcription of genes required for S phase, including transcription of additional cyclin E. CCNE1, CDC34, CDK2, CUL1, E2F1, FBXW7, RB1, SKP1A, TFDP1 8 CCNE1(4), CDC34(3), CUL1(5), E2F1(5), FBXW7(11), RB1(10), TFDP1(2) 3333065 40 32 39 13 17 2 5 5 9 2 0.153 1.000 1.000 41 SA_G2_AND_M_PHASES Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition. CDC2, CDC25A, CDC25B, CDK7, CDKN1A, CHEK1, NEK1, WEE1 7 CDC25A(8), CDC25B(4), CDK7(2), CDKN1A(3), CHEK1(2), NEK1(7), WEE1(2) 2820261 28 23 28 8 15 5 1 3 4 0 0.209 1.000 1.000 42 VOBESITYPATHWAY The adipose tissue of obese individuals overexpresses a key glucocorticoid-metabolizing enzyme, activating inactive circulating corticosteroids and inducing insulin resistance. APM1, HSD11B1, LPL, NR3C1, PPARG, RETN, RXRA, TNF 6 LPL(6), NR3C1(7), PPARG(14), RETN(3), RXRA(4), TNF(1) 2135420 35 31 33 15 17 6 0 6 6 0 0.226 1.000 1.000 43 ASBCELLPATHWAY B cells require interaction with helper T cells to produce antigen-specific immunoglobulins as a key element of the human immune response. CD28, CD4, CD80, HLA-DRA, HLA-DRB1, IL10, IL2, IL4, TNFRSF5, TNFRSF6, TNFSF5, TNFSF6 8 CD28(2), CD4(8), CD80(4), HLA-DRA(12), IL10(3), IL2(4), IL4(1) 1613931 34 28 31 18 24 1 0 4 5 0 0.197 1.000 1.000 44 HSA00950_ALKALOID_BIOSYNTHESIS_I Genes involved in alkaloid biosynthesis I DDC, GOT1, GOT2, TAT, TYR 5 DDC(14), GOT1(6), GOT2(6), TAT(19), TYR(9) 1923961 54 34 52 25 41 5 3 1 4 0 0.177 1.000 1.000 45 FOLATE_BIOSYNTHESIS ALPI, ALPL, ALPP, ALPP, ALPPL2, ALPPL2, DHFR, FPGS, GCH1, GGH, SPR 9 ALPI(9), ALPL(11), ALPP(10), ALPPL2(12), DHFR(2), FPGS(3), GGH(3), SPR(4) 2609292 54 37 50 24 38 5 4 1 6 0 0.0244 1.000 1.000 46 RECKPATHWAY RECK is a membrane-anchored inhibitor of matrix metalloproteinases, which are expressed by tumor cells and promote metastasis. HRAS, MMP14, MMP2, MMP9, RECK, TIMP1, TIMP2, TIMP3, TIMP4 9 HRAS(3), MMP14(3), MMP2(8), MMP9(7), RECK(11), TIMP1(1), TIMP2(1), TIMP3(5), TIMP4(6) 3046109 45 37 43 18 24 3 2 10 6 0 0.189 1.000 1.000 47 HSA00300_LYSINE_BIOSYNTHESIS Genes involved in lysine biosynthesis AADAT, AASDHPPT, AASS, KARS 4 AADAT(5), AASDHPPT(3), AASS(3), KARS(3) 1908246 14 14 14 6 13 0 0 1 0 0 0.538 1.000 1.000 48 ETCPATHWAY Energy is extracted from carbohydrates via oxidation and transferred to the mitochondrial electron transport chain, which couples ATP synthesis to the reduction of oxygen to water. ATP5A1, CYCS, GPD2, MTCO1, NDUFA1, SDHA, SDHB, SDHC, SDHD, UQCRC1 9 ATP5A1(1), CYCS(1), GPD2(3), SDHA(3), SDHC(3), SDHD(1), UQCRC1(4) 2720830 16 16 16 7 10 0 1 3 2 0 0.526 1.000 1.000 49 SKP2E2FPATHWAY E2F-1, a transcription factor that promotes the G1/S transition, is repressed by Rb and activated by cdk2/cyclin E. CCNA1, CCNE1, CDC34, CDK2, CUL1, E2F1, RB1, SKP1A, SKP2, TFDP1 9 CCNA1(14), CCNE1(4), CDC34(3), CUL1(5), E2F1(5), RB1(10), SKP2(2), TFDP1(2) 3480476 45 37 45 17 25 2 4 6 6 2 0.168 1.000 1.000 50 GSPATHWAY Activated G-protein coupled receptors stimulate cAMP production and thus activate protein kinase A, involved in a number of signal transduction pathways. ADCY1, GNAS, GNB1, GNGT1, PRKACA, PRKAR1A 6 ADCY1(34), GNAS(25), GNB1(1), PRKACA(3), PRKAR1A(3) 2667976 66 46 63 27 38 11 4 7 6 0 0.117 1.000 1.000 51 UREACYCLEPATHWAY Ammonia released from amino acid deamination is used to produce carbamoyl phosphate, which is used to convert ornithine to citrulline, from which urea is eventually formed. ARG1, ASL, ASS, CPS1, GLS, GLUD1, GOT1 6 ARG1(2), ASL(6), CPS1(26), GLS(2), GLUD1(2), GOT1(6) 3133142 44 32 41 15 30 4 1 7 2 0 0.0998 1.000 1.000 52 CYSTEINE_METABOLISM CARS, CTH, GOT1, GOT2, LDHA, LDHB, LDHC, MPST 8 CARS(8), CTH(1), GOT1(6), GOT2(6), LDHA(4), LDHB(2), LDHC(5), MPST(2) 2811099 34 27 33 13 25 2 6 0 1 0 0.124 1.000 1.000 53 HSA00930_CAPROLACTAM_DEGRADATION Genes involved in caprolactam degradation AKR1A1, ASAHL, ECHS1, EHHADH, HADH, HADHA, HSD17B10, HSD17B4, NTAN1, SIRT1, SIRT2, SIRT5, SIRT7, VNN2, VNN3 13 AKR1A1(3), ECHS1(3), EHHADH(6), HADH(2), HADHA(6), HSD17B10(2), HSD17B4(6), NTAN1(1), SIRT1(2), SIRT2(1), SIRT5(4), SIRT7(3), VNN2(17) 4841637 56 47 54 17 37 6 3 6 4 0 0.0364 1.000 1.000 54 P35ALZHEIMERSPATHWAY p35, a neuron-specific activator of cyclin-dependent kinase 5, is cleaved to p25 in Alzheimer's disease and promotoes hyperphosphorylated tau formation and apoptosis. APP, CAPN1, CAPNS1, CAPNS2, CDK5, CDK5R1, CSNK1A1, CSNK1D, GSK3B, MAPT, PPP2CA 11 APP(11), CAPN1(4), CAPNS1(3), CAPNS2(1), CDK5(6), CDK5R1(1), CSNK1A1(3), CSNK1D(3), GSK3B(3), MAPT(11) 3676435 46 38 45 18 30 2 1 6 7 0 0.118 1.000 1.000 55 ERYTHPATHWAY Erythropoietin selectively stimulates erythrocyte differentiation from CFU-GEMM cells in bone marrow. CCL3, CSF2, CSF3, EPO, FLT3, IGF1, IL11, IL1A, IL3, IL6, IL9, KITLG, TGFB1, TGFB2, TGFB3 15 CSF2(2), CSF3(4), EPO(5), FLT3(35), IGF1(10), IL11(3), IL1A(5), IL3(3), IL6(2), IL9(1), KITLG(11), TGFB1(2), TGFB2(3), TGFB3(3) 3364761 89 62 83 31 52 6 5 13 13 0 0.00645 1.000 1.000 56 PHENYLALANINE_TYROSINE_AND_TRYPTOPHAN_BIOSYNTHESIS ENO1, ENO2, ENO3, FARS2, FARSLB, GOT1, GOT2, PAH, TAT, YARS 9 ENO1(4), ENO2(5), ENO3(3), FARS2(6), GOT1(6), GOT2(6), PAH(12), TAT(19), YARS(3) 3412382 64 48 60 26 43 6 2 6 7 0 0.0240 1.000 1.000 57 HSA04510_FOCAL_ADHESION Genes involved in focal adhesion ACTB, ACTG1, ACTN1, ACTN2, ACTN3, ACTN4, AKT1, AKT2, AKT3, ARHGAP5, BAD, BCAR1, BCL2, BIRC2, BIRC3, BIRC4, BRAF, CAPN2, CAV1, CAV2, CAV3, CCND1, CCND2, CCND3, CDC42, CHAD, COL11A1, COL11A2, COL1A1, COL1A2, COL2A1, COL3A1, COL4A1, COL4A2, COL4A4, COL4A6, COL5A1, COL5A2, COL5A3, COL6A1, COL6A2, COL6A3, COL6A6, COMP, CRK, CRKL, CTNNB1, DIAPH1, DOCK1, EGF, EGFR, ELK1, ERBB2, FARP2, FIGF, FLNA, FLNB, FLNC, FLT1, FN1, FYN, GRB2, GRLF1, GSK3B, HGF, HRAS, IBSP, IGF1, IGF1R, ILK, ITGA1, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAV, ITGB1, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, JUN, KDR, LAMA1, LAMA2, LAMA3, LAMA4, LAMA5, LAMB1, LAMB2, LAMB3, LAMB4, LAMC1, LAMC2, LAMC3, LOC653852, MAP2K1, MAPK1, MAPK10, MAPK3, MAPK8, MAPK9, MET, MLCK, MRCL3, MRLC2, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLK, MYLK2, MYLPF, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PARVA, PARVB, PARVG, PDGFA, PDGFB, PDGFC, PDGFD, PDGFRA, PDGFRB, PDPK1, PGF, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIP5K1C, PPP1CA, PPP1CB, PPP1CC, PPP1R12A, PRKCA, PRKCB1, PRKCG, PTEN, PTK2, PXN, RAC1, RAC2, RAC3, RAF1, RAP1A, RAP1B, RAPGEF1, RELN, RHOA, ROCK1, ROCK2, SHC1, SHC2, SHC3, SHC4, SOS1, SOS2, SPP1, SRC, THBS1, THBS2, THBS3, THBS4, TLN1, TLN2, TNC, TNN, TNR, TNXB, VASP, VAV1, VAV2, VAV3, VCL, VEGFA, VEGFB, VEGFC, VTN, VWF, ZYX 188 ACTB(8), ACTG1(6), ACTN1(8), ACTN2(20), ACTN3(3), ACTN4(5), AKT1(4), AKT2(8), AKT3(3), ARHGAP5(13), BCAR1(5), BCL2(2), BIRC2(6), BIRC3(7), CAPN2(5), CAV1(1), CAV3(2), CCND1(2), CCND2(6), CCND3(2), CDC42(2), CHAD(3), COL11A1(71), COL11A2(45), COL1A1(48), COL1A2(44), COL2A1(42), COL3A1(81), COL4A1(64), COL4A2(35), COL4A4(114), COL4A6(42), COL5A1(80), COL5A2(54), COL5A3(75), COL6A1(11), COL6A2(24), COL6A3(67), COL6A6(62), COMP(8), CRK(3), CRKL(3), CTNNB1(14), DIAPH1(9), DOCK1(17), EGF(21), EGFR(25), ELK1(3), ERBB2(9), FARP2(4), FIGF(5), FLNA(21), FLNB(41), FLNC(65), FLT1(38), FN1(25), FYN(7), GRB2(2), GSK3B(3), HGF(29), HRAS(3), IBSP(9), IGF1(10), IGF1R(14), ILK(2), ITGA1(24), ITGA10(12), ITGA11(19), ITGA2(13), ITGA2B(12), ITGA3(8), ITGA4(43), ITGA5(25), ITGA6(10), ITGA7(25), ITGA8(37), ITGA9(13), ITGAV(9), ITGB1(4), ITGB3(15), ITGB4(22), ITGB5(9), ITGB6(11), ITGB7(6), ITGB8(20), JUN(1), KDR(55), LAMA1(46), LAMA2(68), LAMA3(67), LAMA4(12), LAMA5(38), LAMB1(14), LAMB2(13), LAMB3(26), LAMB4(46), LAMC1(12), LAMC2(22), LAMC3(10), MAP2K1(14), MAPK1(4), MAPK10(9), MAPK3(4), MAPK8(1), MAPK9(3), MET(23), MYL2(9), MYL5(1), MYL7(3), MYL9(2), MYLK(46), MYLK2(12), MYLPF(2), PAK1(4), PAK2(7), PAK3(10), PAK4(8), PAK6(6), PAK7(55), PARVA(2), PARVB(4), PARVG(3), PDGFA(1), PDGFB(6), PDGFC(16), PDGFD(6), PDGFRA(34), PDGFRB(21), PDPK1(3), PGF(1), PIK3CA(10), PIK3CB(14), PIK3CD(8), PIK3CG(27), PIK3R1(2), PIK3R2(5), PIK3R3(2), PIK3R5(16), PIP5K1C(9), PPP1CA(1), PPP1CB(5), PPP1CC(1), PPP1R12A(4), PRKCA(8), PRKCG(16), PTK2(7), PXN(2), RAC2(3), RAF1(10), RAP1A(2), RAP1B(1), RAPGEF1(12), RELN(88), RHOA(2), ROCK1(7), ROCK2(11), SHC1(2), SHC2(6), SHC3(14), SHC4(2), SOS1(10), SOS2(13), SPP1(7), SRC(2), THBS1(30), THBS2(12), THBS3(11), THBS4(19), TLN1(12), TLN2(27), TNC(35), TNN(53), TNR(79), TNXB(128), VASP(3), VAV1(19), VAV2(3), VAV3(14), VCL(8), VEGFA(4), VEGFB(2), VTN(8), VWF(56), ZYX(8) 149787864 3417 259 3246 1453 2391 230 100 288 394 14 8.53e-12 1.000 1.000 58 HSA04080_NEUROACTIVE_LIGAND_RECEPTOR_INTERACTION Genes involved in neuroactive ligand-receptor interaction ADCYAP1R1, ADORA1, ADORA2A, ADORA2B, ADORA3, ADRA1A, ADRA1B, ADRA2A, ADRA2B, ADRA2C, ADRB1, ADRB2, ADRB3, AGTR1, AGTR2, AGTRL1, AVPR1A, AVPR1B, AVPR2, BDKRB1, BDKRB2, BRS3, C3AR1, C5AR1, CALCR, CALCRL, CCKAR, CCKBR, CGA, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, CNR1, CNR2, CRHR1, CRHR2, CTSG, CYSLTR1, CYSLTR2, DRD1, DRD2, DRD3, DRD4, DRD5, EDG1, EDG2, EDG3, EDG4, EDG5, EDG6, EDG7, EDG8, EDNRA, EDNRB, F2, F2R, F2RL1, F2RL2, F2RL3, FPR1, FPRL1, FPRL2, FSHB, FSHR, GABBR1, GABBR2, GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GABRB1, GABRB2, GABRB3, GABRD, GABRE, GABRG1, GABRG2, GABRG3, GABRP, GABRQ, GABRR1, GABRR2, GALR1, GALR2, GALR3, GCGR, GH1, GH2, GHR, GHRHR, GHSR, GIPR, GLP1R, GLP2R, GLRA1, GLRA2, GLRA3, GLRB, GNRHR, GPR156, GPR23, GPR35, GPR50, GPR63, GPR83, GRIA1, GRIA2, GRIA3, GRIA4, GRID1, GRID2, GRIK1, GRIK2, GRIK3, GRIK4, GRIK5, GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D, GRIN3A, GRIN3B, GRM1, GRM2, GRM3, GRM4, GRM5, GRM6, GRM7, GRM8, GRPR, GZMA, HCRTR1, HCRTR2, HRH1, HRH2, HRH3, HRH4, HTR1A, HTR1B, HTR1D, HTR1E, HTR1F, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, KISS1R, LEP, LEPR, LHB, LHCGR, LTB4R, LTB4R2, MAS1, MC1R, MC2R, MC3R, MC4R, MC5R, MCHR1, MCHR2, MLNR, MTNR1A, MTNR1B, NMBR, NMUR1, NMUR2, NPBWR1, NPBWR2, NPFFR1, NPFFR2, NPY1R, NPY2R, NPY5R, NR3C1, NTSR1, NTSR2, OPRD1, OPRK1, OPRL1, OPRM1, OXTR, P2RX1, P2RX2, P2RX3, P2RX4, P2RX5, P2RX7, P2RXL1, P2RY1, P2RY10, P2RY11, P2RY13, P2RY14, P2RY2, P2RY4, P2RY5, P2RY6, P2RY8, PARD3, PPYR1, PRL, PRLHR, PRLR, PRSS1, PRSS2, PRSS3, PTAFR, PTGDR, PTGER1, PTGER2, PTGER3, PTGER4, PTGFR, PTGIR, PTH2R, PTHR1, RXFP1, RXFP2, SCTR, SSTR1, SSTR2, SSTR3, SSTR4, SSTR5, TAAR1, TAAR2, TAAR5, TAAR6, TAAR8, TAAR9, TACR1, TACR2, TACR3, TBXA2R, THRA, THRB, TRHR, TRPV1, TSHB, TSHR, TSPO, UTS2R, VIPR1, VIPR2 235 ADCYAP1R1(19), ADORA1(6), ADORA2A(3), ADORA2B(1), ADORA3(15), ADRA1A(9), ADRA1B(4), ADRA2A(3), ADRA2B(10), ADRA2C(2), ADRB1(5), ADRB2(3), AGTR1(10), AGTR2(9), AVPR1A(4), AVPR1B(11), BDKRB1(6), BDKRB2(9), BRS3(5), C3AR1(5), C5AR1(10), CALCR(18), CALCRL(19), CCKAR(11), CCKBR(11), CGA(1), CHRM1(5), CHRM2(25), CHRM3(26), CHRM4(6), CHRM5(7), CNR1(13), CNR2(5), CRHR1(7), CRHR2(4), CTSG(4), CYSLTR1(5), CYSLTR2(4), DRD1(9), DRD2(14), DRD3(6), DRD4(1), DRD5(25), EDNRA(10), EDNRB(7), F2(11), F2R(8), F2RL1(16), F2RL2(8), F2RL3(4), FPR1(21), FSHB(8), FSHR(19), GABBR1(8), GABBR2(12), GABRA1(18), GABRA2(18), GABRA3(22), GABRA4(15), GABRA5(4), GABRA6(28), GABRB1(17), GABRB2(25), GABRB3(22), GABRD(5), GABRE(23), GABRG1(36), GABRG2(17), GABRG3(9), GABRP(16), GABRQ(9), GABRR1(10), GALR1(5), GALR3(2), GH1(3), GH2(10), GHR(40), GHRHR(5), GHSR(11), GIPR(3), GLP1R(13), GLP2R(15), GLRA1(13), GLRA2(6), GLRA3(17), GLRB(29), GNRHR(2), GPR156(13), GPR35(6), GPR50(19), GPR63(9), GPR83(13), GRIA1(45), GRIA2(41), GRIA3(24), GRIA4(26), GRID1(28), GRID2(59), GRIK1(27), GRIK2(29), GRIK3(32), GRIK4(16), GRIK5(9), GRIN1(8), GRIN2A(105), GRIN2B(57), GRIN2C(8), GRIN2D(10), GRIN3A(51), GRIN3B(4), GRM1(16), GRM2(13), GRM3(62), GRM4(21), GRM5(15), GRM6(31), GRM7(40), GRM8(48), GRPR(7), HCRTR1(2), HCRTR2(33), HRH1(14), HRH2(3), HRH3(5), HRH4(6), HTR1A(10), HTR1B(1), HTR1D(6), HTR1E(7), HTR1F(9), HTR2A(11), HTR2B(2), HTR2C(13), HTR4(9), HTR5A(19), HTR6(1), HTR7(9), LEP(4), LEPR(29), LHCGR(27), LTB4R(1), MAS1(4), MC2R(5), MC3R(7), MC4R(1), MC5R(8), MCHR1(4), MCHR2(20), MLNR(1), MTNR1A(10), MTNR1B(8), NMBR(7), NMUR1(8), NMUR2(16), NPBWR1(3), NPBWR2(11), NPFFR1(1), NPFFR2(13), NPY1R(29), NPY2R(13), NPY5R(24), NR3C1(7), NTSR1(7), NTSR2(2), OPRD1(3), OPRK1(24), OPRL1(8), OPRM1(5), OXTR(5), P2RX1(3), P2RX2(2), P2RX3(9), P2RX4(3), P2RX5(8), P2RX7(4), P2RY1(5), P2RY10(7), P2RY13(4), P2RY14(8), P2RY2(8), P2RY4(2), P2RY6(2), P2RY8(7), PARD3(18), PPYR1(14), PRL(3), PRLHR(1), PRLR(35), PRSS1(27), PRSS3(6), PTAFR(2), PTGDR(11), PTGER2(7), PTGER3(6), PTGER4(2), PTGFR(21), PTGIR(5), PTH2R(16), RXFP1(19), RXFP2(25), SCTR(6), SSTR1(10), SSTR2(7), SSTR3(11), SSTR4(4), SSTR5(5), TAAR1(3), TAAR2(11), TAAR5(4), TAAR6(11), TAAR8(7), TAAR9(3), TACR1(8), TACR2(7), TACR3(27), TBXA2R(4), THRA(2), THRB(18), TRHR(23), TRPV1(2), TSHB(6), TSHR(8), UTS2R(1), VIPR1(7), VIPR2(7) 89533048 2834 255 2604 1707 1966 240 91 254 277 6 7.11e-13 1.000 1.000 59 HSA01430_CELL_COMMUNICATION Genes involved in cell communication ACTB, ACTG1, CHAD, COL11A1, COL11A2, COL17A1, COL1A1, COL1A2, COL2A1, COL3A1, COL4A1, COL4A2, COL4A4, COL4A6, COL5A1, COL5A2, COL5A3, COL6A1, COL6A2, COL6A3, COL6A6, COMP, DES, DSC1, DSC2, DSC3, DSG1, DSG2, DSG3, DSG4, FN1, GJA1, GJA10, GJA3, GJA4, GJA5, GJA8, GJA9, GJB1, GJB2, GJB3, GJB4, GJB5, GJB6, GJB7, GJC1, GJC2, GJC3, GJD2, GJD3, GJD4, IBSP, INA, ITGA6, ITGB4, KRT1, KRT10, KRT12, KRT13, KRT14, KRT15, KRT16, KRT17, KRT18, KRT19, KRT2, KRT20, KRT23, KRT24, KRT25, KRT27, KRT28, KRT3, KRT31, KRT32, KRT33A, KRT33B, KRT34, KRT35, KRT36, KRT37, KRT38, KRT39, KRT4, KRT40, KRT5, KRT6A, KRT6B, KRT6C, KRT7, KRT71, KRT72, KRT73, KRT74, KRT75, KRT76, KRT77, KRT78, KRT79, KRT8, KRT81, KRT82, KRT83, KRT84, KRT85, KRT86, KRT9, LAMA1, LAMA2, LAMA3, LAMA4, LAMA5, LAMB1, LAMB2, LAMB3, LAMB4, LAMC1, LAMC2, LAMC3, LMNA, LMNB1, LMNB2, LOC728760, NES, PRPH, RELN, SPP1, THBS1, THBS2, THBS3, THBS4, TNC, TNN, TNR, TNXB, VIM, VTN, VWF 136 ACTB(8), ACTG1(6), CHAD(3), COL11A1(71), COL11A2(45), COL17A1(28), COL1A1(48), COL1A2(44), COL2A1(42), COL3A1(81), COL4A1(64), COL4A2(35), COL4A4(114), COL4A6(42), COL5A1(80), COL5A2(54), COL5A3(75), COL6A1(11), COL6A2(24), COL6A3(67), COL6A6(62), COMP(8), DES(9), DSC1(48), DSC2(43), DSC3(47), DSG1(63), DSG2(25), DSG3(65), DSG4(66), FN1(25), GJA1(9), GJA10(17), GJA3(1), GJA4(4), GJA5(10), GJA8(19), GJA9(3), GJB1(1), GJB2(3), GJB3(4), GJB4(8), GJB5(8), GJB6(6), GJB7(2), GJC1(6), GJC3(2), GJD2(5), IBSP(9), INA(7), ITGA6(10), ITGB4(22), KRT1(20), KRT10(14), KRT12(10), KRT13(13), KRT14(3), KRT15(9), KRT16(12), KRT17(9), KRT18(4), KRT2(18), KRT20(7), KRT23(10), KRT24(7), KRT25(12), KRT27(6), KRT28(13), KRT3(16), KRT31(9), KRT32(13), KRT33A(6), KRT33B(4), KRT34(11), KRT35(11), KRT36(18), KRT37(13), KRT38(9), KRT39(16), KRT4(21), KRT40(7), KRT5(16), KRT6A(15), KRT6B(9), KRT6C(16), KRT7(5), KRT71(19), KRT72(11), KRT73(16), KRT74(16), KRT75(16), KRT76(18), KRT77(14), KRT78(24), KRT79(8), KRT8(7), KRT81(4), KRT82(6), KRT83(16), KRT84(12), KRT85(7), KRT86(8), KRT9(23), LAMA1(46), LAMA2(68), LAMA3(67), LAMA4(12), LAMA5(38), LAMB1(14), LAMB2(13), LAMB3(26), LAMB4(46), LAMC1(12), LAMC2(22), LAMC3(10), LMNA(7), LMNB1(1), LMNB2(4), NES(24), PRPH(1), RELN(88), SPP1(7), THBS1(30), THBS2(12), THBS3(11), THBS4(19), TNC(35), TNN(53), TNR(79), TNXB(128), VIM(5), VTN(8), VWF(56) 101808327 3108 253 2941 1287 2264 225 78 215 315 11 2.78e-15 1.000 1.000 60 HSA04512_ECM_RECEPTOR_INTERACTION Genes involved in ECM-receptor interaction AGRN, CD36, CD44, CD47, CHAD, COL11A1, COL11A2, COL1A1, COL1A2, COL2A1, COL3A1, COL4A1, COL4A2, COL4A4, COL4A6, COL5A1, COL5A2, COL5A3, COL6A1, COL6A2, COL6A3, COL6A6, DAG1, FN1, FNDC1, FNDC3A, FNDC4, FNDC5, GP1BA, GP1BB, GP5, GP6, GP9, HMMR, HSPG2, IBSP, ITGA1, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAV, ITGB1, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, LAMA1, LAMA2, LAMA3, LAMA4, LAMA5, LAMB1, LAMB2, LAMB3, LAMB4, LAMC1, LAMC2, LAMC3, RELN, SDC1, SDC2, SDC3, SDC4, SPP1, SV2A, SV2B, SV2C, THBS1, THBS2, THBS3, THBS4, TNC, TNN, TNR, TNXB, VTN, VWF 85 AGRN(16), CD36(6), CD44(5), CD47(1), CHAD(3), COL11A1(71), COL11A2(45), COL1A1(48), COL1A2(44), COL2A1(42), COL3A1(81), COL4A1(64), COL4A2(35), COL4A4(114), COL4A6(42), COL5A1(80), COL5A2(54), COL5A3(75), COL6A1(11), COL6A2(24), COL6A3(67), COL6A6(62), DAG1(9), FN1(25), FNDC1(43), FNDC3A(11), FNDC4(5), FNDC5(3), GP5(7), GP6(5), GP9(6), HMMR(4), HSPG2(30), IBSP(9), ITGA1(24), ITGA10(12), ITGA11(19), ITGA2(13), ITGA2B(12), ITGA3(8), ITGA4(43), ITGA5(25), ITGA6(10), ITGA7(25), ITGA8(37), ITGA9(13), ITGAV(9), ITGB1(4), ITGB3(15), ITGB4(22), ITGB5(9), ITGB6(11), ITGB7(6), ITGB8(20), LAMA1(46), LAMA2(68), LAMA3(67), LAMA4(12), LAMA5(38), LAMB1(14), LAMB2(13), LAMB3(26), LAMB4(46), LAMC1(12), LAMC2(22), LAMC3(10), RELN(88), SDC1(3), SDC2(2), SDC3(7), SDC4(3), SPP1(7), SV2A(15), SV2B(29), SV2C(22), THBS1(30), THBS2(12), THBS3(11), THBS4(19), TNC(35), TNN(53), TNR(79), TNXB(128), VTN(8), VWF(56) 91372292 2465 248 2352 1006 1779 146 73 175 280 12 3.93e-07 1.000 1.000 61 HSA04010_MAPK_SIGNALING_PATHWAY Genes involved in MAPK signaling pathway ACVR1B, ACVR1C, AKT1, AKT2, AKT3, ARRB1, ARRB2, ATF2, ATF4, BDNF, BRAF, CACNA1A, CACNA1B, CACNA1C, CACNA1D, CACNA1E, CACNA1F, CACNA1G, CACNA1H, CACNA1I, CACNA1S, CACNA2D1, CACNA2D2, CACNA2D3, CACNA2D4, CACNB1, CACNB2, CACNB3, CACNB4, CACNG1, CACNG2, CACNG3, CACNG4, CACNG5, CACNG6, CACNG7, CACNG8, CASP3, CD14, CDC25B, CDC42, CHP, CHUK, CRK, CRKL, DAXX, DDIT3, DUSP1, DUSP10, DUSP14, DUSP16, DUSP2, DUSP3, DUSP4, DUSP5, DUSP6, DUSP7, DUSP8, DUSP9, ECSIT, EGF, EGFR, ELK1, ELK4, EVI1, FAS, FASLG, FGF1, FGF10, FGF11, FGF12, FGF13, FGF14, FGF16, FGF17, FGF18, FGF19, FGF2, FGF20, FGF21, FGF22, FGF23, FGF3, FGF4, FGF5, FGF6, FGF7, FGF8, FGF9, FGFR1, FGFR2, FGFR3, FGFR4, FLNA, FLNB, FLNC, FOS, GADD45A, GADD45B, GADD45G, GNA12, GNG12, GRB2, HRAS, IKBKB, IKBKG, IL1A, IL1B, IL1R1, IL1R2, JUN, JUND, KRAS, LOC653852, MAP2K1, MAP2K1IP1, MAP2K2, MAP2K3, MAP2K4, MAP2K5, MAP2K6, MAP2K7, MAP3K1, MAP3K10, MAP3K12, MAP3K13, MAP3K14, MAP3K2, MAP3K3, MAP3K4, MAP3K5, MAP3K6, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAP3K8, MAP4K1, MAP4K2, MAP4K3, MAP4K4, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK7, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MAPKAPK2, MAPKAPK3, MAPKAPK5, MAPT, MAX, MEF2C, MKNK1, MKNK2, MOS, MRAS, MYC, NF1, NFATC2, NFATC4, NFKB1, NFKB2, NGFB, NLK, NR4A1, NRAS, NTF3, NTF5, NTRK1, NTRK2, PAK1, PAK2, PDGFA, PDGFB, PDGFRA, PDGFRB, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PPM1A, PPM1B, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PPP5C, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, PTPN5, PTPN7, PTPRR, RAC1, RAC2, RAC3, RAF1, RAP1A, RAP1B, RAPGEF2, RASA1, RASA2, RASGRF1, RASGRF2, RASGRP1, RASGRP2, RASGRP3, RASGRP4, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA4, RPS6KA5, RPS6KA6, RRAS, RRAS2, SOS1, SOS2, SRF, STK3, STK4, STMN1, TAOK1, TAOK2, TAOK3, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TNF, TNFRSF1A, TP53, TRAF2, TRAF6, ZAK 243 ACVR1B(3), ACVR1C(10), AKT1(4), AKT2(8), AKT3(3), ARRB1(5), ARRB2(6), ATF2(6), ATF4(9), BDNF(4), CACNA1A(38), CACNA1B(35), CACNA1C(62), CACNA1D(33), CACNA1E(111), CACNA1F(23), CACNA1G(36), CACNA1H(29), CACNA1I(39), CACNA1S(53), CACNA2D1(16), CACNA2D2(16), CACNA2D3(60), CACNA2D4(25), CACNB1(4), CACNB2(14), CACNB3(2), CACNB4(12), CACNG1(3), CACNG2(12), CACNG3(24), CACNG4(4), CACNG5(10), CACNG6(6), CACNG7(6), CACNG8(1), CASP3(2), CD14(5), CDC25B(4), CDC42(2), CHUK(2), CRK(3), CRKL(3), DAXX(9), DDIT3(2), DUSP1(1), DUSP10(7), DUSP14(2), DUSP16(4), DUSP2(1), DUSP3(1), DUSP4(2), DUSP5(2), DUSP6(2), DUSP7(2), DUSP8(3), DUSP9(3), ECSIT(1), EGF(21), EGFR(25), ELK1(3), FAS(6), FASLG(15), FGF1(1), FGF10(3), FGF11(3), FGF12(15), FGF13(7), FGF14(5), FGF16(7), FGF17(3), FGF18(3), FGF19(3), FGF2(1), FGF20(2), FGF21(5), FGF23(10), FGF3(6), FGF4(2), FGF5(10), FGF6(6), FGF7(7), FGF8(1), FGF9(5), FGFR1(11), FGFR2(32), FGFR3(9), FGFR4(11), FLNA(21), FLNB(41), FLNC(65), FOS(2), GADD45B(2), GNA12(3), GRB2(2), HRAS(3), IKBKB(4), IL1A(5), IL1B(8), IL1R1(13), IL1R2(8), JUN(1), JUND(1), KRAS(5), MAP2K1(14), MAP2K2(5), MAP2K3(8), MAP2K4(4), MAP2K5(4), MAP2K6(3), MAP2K7(5), MAP3K1(4), MAP3K10(9), MAP3K12(3), MAP3K13(15), MAP3K14(6), MAP3K2(6), MAP3K3(8), MAP3K4(17), MAP3K5(23), MAP3K6(5), MAP3K7(1), MAP4K1(11), MAP4K2(7), MAP4K3(11), MAP4K4(16), MAPK1(4), MAPK10(9), MAPK11(1), MAPK12(1), MAPK13(5), MAPK14(5), MAPK3(4), MAPK7(4), MAPK8(1), MAPK8IP1(7), MAPK8IP2(7), MAPK8IP3(10), MAPK9(3), MAPKAPK2(5), MAPKAPK3(5), MAPKAPK5(1), MAPT(11), MEF2C(4), MKNK1(6), MKNK2(3), MOS(6), MRAS(2), MYC(5), NF1(46), NFATC2(11), NFATC4(17), NFKB1(6), NFKB2(3), NLK(5), NR4A1(4), NTF3(6), NTRK1(16), NTRK2(10), PAK1(4), PAK2(7), PDGFA(1), PDGFB(6), PDGFRA(34), PDGFRB(21), PLA2G12B(4), PLA2G1B(1), PLA2G2A(2), PLA2G2D(5), PLA2G2E(5), PLA2G2F(6), PLA2G3(17), PLA2G4A(15), PLA2G5(2), PLA2G6(12), PPM1A(3), PPM1B(7), PPP3CA(5), PPP3CB(3), PPP3CC(2), PPP3R2(5), PPP5C(3), PRKACA(3), PRKACB(4), PRKACG(11), PRKCA(8), PRKCG(16), PRKX(3), PTPN5(13), PTPN7(3), PTPRR(30), RAC2(3), RAF1(10), RAP1A(2), RAP1B(1), RAPGEF2(9), RASA1(4), RASA2(15), RASGRF1(21), RASGRF2(24), RASGRP1(11), RASGRP2(7), RASGRP3(12), RASGRP4(11), RPS6KA1(8), RPS6KA2(6), RPS6KA3(1), RPS6KA4(4), RPS6KA5(7), RPS6KA6(19), RRAS(1), RRAS2(1), SOS1(10), SOS2(13), SRF(3), STK3(1), STK4(4), STMN1(3), TAOK1(10), TAOK2(27), TAOK3(3), TGFB1(2), TGFB2(3), TGFB3(3), TGFBR2(9), TNF(1), TNFRSF1A(4), TRAF2(2), TRAF6(4) 113893018 2175 246 2079 1220 1411 197 67 208 285 7 0.0359 1.000 1.000 62 HSA04810_REGULATION_OF_ACTIN_CYTOSKELETON Genes involved in regulation of actin cytoskeleton ABI2, ACTN1, ACTN2, ACTN3, ACTN4, APC, APC2, ARAF, ARHGEF1, ARHGEF12, ARHGEF4, ARHGEF6, ARHGEF7, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, ARPC5, ARPC5L, BAIAP2, BCAR1, BDKRB1, BDKRB2, BRAF, C3orf10, CD14, CDC42, CFL1, CFL2, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, CRK, CRKL, CSK, CYFIP1, CYFIP2, DIAPH1, DIAPH2, DIAPH3, DOCK1, EGF, EGFR, EZR, F2, F2R, FGD1, FGD3, FGF1, FGF10, FGF11, FGF12, FGF13, FGF14, FGF16, FGF17, FGF18, FGF19, FGF2, FGF20, FGF21, FGF22, FGF23, FGF3, FGF4, FGF5, FGF6, FGF7, FGF8, FGF9, FGFR1, FGFR2, FGFR3, FGFR4, FN1, GIT1, GNA12, GNA13, GNG12, GRLF1, GSN, HRAS, INS, IQGAP1, IQGAP2, IQGAP3, ITGA1, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAD, ITGAE, ITGAL, ITGAM, ITGAV, ITGAX, ITGB1, ITGB2, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, KRAS, LIMK1, LIMK2, LOC200025, LOC645126, LOC653888, MAP2K1, MAP2K2, MAPK1, MAPK3, MLCK, MOS, MRAS, MRCL3, MRLC2, MSN, MYH10, MYH14, MYH9, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLK, MYLK2, MYLPF, NCKAP1, NCKAP1L, NRAS, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PDGFA, PDGFB, PDGFRA, PDGFRB, PFN1, PFN2, PFN3, PFN4, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIP4K2A, PIP4K2B, PIP4K2C, PIP5K1A, PIP5K1B, PIP5K1C, PIP5K3, PPP1CA, PPP1CB, PPP1CC, PPP1R12A, PPP1R12B, PTK2, PXN, RAC1, RAC2, RAC3, RAF1, RDX, RHOA, ROCK1, ROCK2, RRAS, RRAS2, SCIN, SLC9A1, SOS1, SOS2, SSH1, SSH2, SSH3, TIAM1, TIAM2, TMSB4X, TMSB4Y, TMSL3, VAV1, VAV2, VAV3, VCL, WAS, WASF1, WASF2, WASL 200 ACTN1(8), ACTN2(20), ACTN3(3), ACTN4(5), APC(25), APC2(12), ARAF(5), ARHGEF1(1), ARHGEF12(12), ARHGEF4(4), ARHGEF6(10), ARHGEF7(6), ARPC1B(3), ARPC2(1), ARPC3(1), ARPC5(1), BAIAP2(7), BCAR1(5), BDKRB1(6), BDKRB2(9), CD14(5), CDC42(2), CFL1(2), CHRM1(5), CHRM2(25), CHRM3(26), CHRM4(6), CHRM5(7), CRK(3), CRKL(3), CSK(1), CYFIP1(9), CYFIP2(25), DIAPH1(9), DIAPH2(6), DIAPH3(17), DOCK1(17), EGF(21), EGFR(25), EZR(5), F2(11), F2R(8), FGD1(5), FGD3(9), FGF1(1), FGF10(3), FGF11(3), FGF12(15), FGF13(7), FGF14(5), FGF16(7), FGF17(3), FGF18(3), FGF19(3), FGF2(1), FGF20(2), FGF21(5), FGF23(10), FGF3(6), FGF4(2), FGF5(10), FGF6(6), FGF7(7), FGF8(1), FGF9(5), FGFR1(11), FGFR2(32), FGFR3(9), FGFR4(11), FN1(25), GIT1(4), GNA12(3), GNA13(1), GSN(6), HRAS(3), IQGAP1(9), IQGAP2(27), IQGAP3(12), ITGA1(24), ITGA10(12), ITGA11(19), ITGA2(13), ITGA2B(12), ITGA3(8), ITGA4(43), ITGA5(25), ITGA6(10), ITGA7(25), ITGA8(37), ITGA9(13), ITGAD(30), ITGAE(21), ITGAL(28), ITGAM(23), ITGAV(9), ITGAX(23), ITGB1(4), ITGB2(16), ITGB3(15), ITGB4(22), ITGB5(9), ITGB6(11), ITGB7(6), ITGB8(20), KRAS(5), LIMK1(5), LIMK2(12), MAP2K1(14), MAP2K2(5), MAPK1(4), MAPK3(4), MOS(6), MRAS(2), MSN(2), MYH10(14), MYH14(23), MYH9(11), MYL2(9), MYL5(1), MYL7(3), MYL9(2), MYLK(46), MYLK2(12), MYLPF(2), NCKAP1(5), NCKAP1L(41), PAK1(4), PAK2(7), PAK3(10), PAK4(8), PAK6(6), PAK7(55), PDGFA(1), PDGFB(6), PDGFRA(34), PDGFRB(21), PFN4(1), PIK3CA(10), PIK3CB(14), PIK3CD(8), PIK3CG(27), PIK3R1(2), PIK3R2(5), PIK3R3(2), PIK3R5(16), PIP4K2A(6), PIP4K2B(3), PIP4K2C(2), PIP5K1A(6), PIP5K1B(21), PIP5K1C(9), PPP1CA(1), PPP1CB(5), PPP1CC(1), PPP1R12A(4), PPP1R12B(7), PTK2(7), PXN(2), RAC2(3), RAF1(10), RDX(3), RHOA(2), ROCK1(7), ROCK2(11), RRAS(1), RRAS2(1), SCIN(9), SLC9A1(5), SOS1(10), SOS2(13), SSH1(15), SSH2(7), SSH3(3), TIAM1(27), TIAM2(26), VAV1(19), VAV2(3), VAV3(14), VCL(8), WAS(8), WASF1(4), WASF2(5), WASL(5) 111102616 1890 246 1807 951 1237 129 70 226 222 6 0.000133 1.000 1.000 63 HSA04020_CALCIUM_SIGNALING_PATHWAY Genes involved in calcium signaling pathway ADCY1, ADCY2, ADCY3, ADCY4, ADCY7, ADCY8, ADCY9, ADORA2A, ADORA2B, ADRA1A, ADRA1B, ADRA1D, ADRB1, ADRB2, ADRB3, AGTR1, ATP2A1, ATP2A2, ATP2A3, ATP2B1, ATP2B2, ATP2B3, ATP2B4, AVPR1A, AVPR1B, BDKRB1, BDKRB2, BST1, CACNA1A, CACNA1B, CACNA1C, CACNA1D, CACNA1E, CACNA1F, CACNA1G, CACNA1H, CACNA1I, CACNA1S, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CCKAR, CCKBR, CD38, CHP, CHRM1, CHRM2, CHRM3, CHRM5, CHRNA7, CYSLTR1, CYSLTR2, DRD1, EDNRA, EDNRB, EGFR, ERBB2, ERBB3, ERBB4, F2R, GNA11, GNA14, GNA15, GNAL, GNAQ, GNAS, GRIN1, GRIN2A, GRIN2C, GRIN2D, GRM1, GRM5, GRPR, HRH1, HRH2, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, LHCGR, LTB4R2, MLCK, MYLK, MYLK2, NOS1, NOS2A, NOS3, NTSR1, OXTR, P2RX1, P2RX2, P2RX3, P2RX4, P2RX5, P2RX7, P2RXL1, PDE1A, PDE1B, PDE1C, PDGFRA, PDGFRB, PHKA1, PHKA2, PHKB, PHKG1, PHKG2, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCD3, PLCD4, PLCE1, PLCG1, PLCG2, PLCZ1, PLN, PPID, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, PTAFR, PTGER1, PTGER3, PTGFR, PTK2B, RYR1, RYR2, RYR3, SLC25A4, SLC25A5, SLC25A6, SLC8A1, SLC8A2, SLC8A3, SPHK1, SPHK2, TACR1, TACR2, TACR3, TBXA2R, TNNC1, TNNC2, TRHR, TRPC1, VDAC1, VDAC2, VDAC3 167 ADCY1(34), ADCY2(10), ADCY3(3), ADCY4(5), ADCY7(11), ADCY8(55), ADCY9(10), ADORA2A(3), ADORA2B(1), ADRA1A(9), ADRA1B(4), ADRA1D(5), ADRB1(5), ADRB2(3), AGTR1(10), ATP2A1(12), ATP2A2(13), ATP2A3(15), ATP2B1(7), ATP2B2(28), ATP2B3(9), ATP2B4(16), AVPR1A(4), AVPR1B(11), BDKRB1(6), BDKRB2(9), BST1(2), CACNA1A(38), CACNA1B(35), CACNA1C(62), CACNA1D(33), CACNA1E(111), CACNA1F(23), CACNA1G(36), CACNA1H(29), CACNA1I(39), CACNA1S(53), CALM1(1), CALM2(1), CALML3(9), CALML6(1), CAMK2A(6), CAMK2B(6), CAMK2D(6), CAMK2G(5), CAMK4(17), CCKAR(11), CCKBR(11), CD38(6), CHRM1(5), CHRM2(25), CHRM3(26), CHRM5(7), CHRNA7(3), CYSLTR1(5), CYSLTR2(4), DRD1(9), EDNRA(10), EDNRB(7), EGFR(25), ERBB2(9), ERBB3(5), ERBB4(54), F2R(8), GNA11(8), GNA14(6), GNA15(6), GNAL(2), GNAQ(6), GNAS(25), GRIN1(8), GRIN2A(105), GRIN2C(8), GRIN2D(10), GRM1(16), GRM5(15), GRPR(7), HRH1(14), HRH2(3), HTR2A(11), HTR2B(2), HTR2C(13), HTR4(9), HTR5A(19), HTR6(1), HTR7(9), ITPKB(11), ITPR1(36), ITPR2(20), ITPR3(11), LHCGR(27), MYLK(46), MYLK2(12), NOS1(74), NOS3(19), NTSR1(7), OXTR(5), P2RX1(3), P2RX2(2), P2RX3(9), P2RX4(3), P2RX5(8), P2RX7(4), PDE1B(16), PDE1C(52), PDGFRA(34), PDGFRB(21), PHKA1(24), PHKA2(9), PHKB(10), PHKG1(1), PHKG2(3), PLCB1(54), PLCB2(12), PLCB3(4), PLCB4(86), PLCD1(4), PLCD3(4), PLCD4(4), PLCE1(57), PLCG1(8), PLCG2(27), PLCZ1(30), PPID(1), PPP3CA(5), PPP3CB(3), PPP3CC(2), PPP3R2(5), PRKACA(3), PRKACB(4), PRKACG(11), PRKCA(8), PRKCG(16), PRKX(3), PTAFR(2), PTGER3(6), PTGFR(21), PTK2B(10), RYR1(109), RYR2(99), RYR3(90), SLC25A6(2), SLC8A1(34), SLC8A2(14), SLC8A3(43), SPHK1(2), SPHK2(7), TACR1(8), TACR2(7), TACR3(27), TBXA2R(4), TNNC1(2), TNNC2(4), TRHR(23), TRPC1(6), VDAC1(1), VDAC2(1), VDAC3(1) 108099749 2685 245 2528 1671 1878 196 96 201 305 9 2.18e-05 1.000 1.000 64 HSA04060_CYTOKINE_CYTOKINE_RECEPTOR_INTERACTION Genes involved in cytokine-cytokine receptor interaction ACVR1, ACVR1B, ACVR2A, ACVR2B, AMH, AMHR2, BMP2, BMP7, BMPR1A, BMPR1B, BMPR2, CCL1, CCL11, CCL13, CCL14, CCL15, CCL16, CCL17, CCL18, CCL19, CCL2, CCL20, CCL21, CCL22, CCL23, CCL24, CCL25, CCL26, CCL27, CCL28, CCL3, CCL4, CCL5, CCL7, CCL8, CCR1, CCR2, CCR3, CCR4, CCR5, CCR6, CCR7, CCR8, CCR9, CD27, CD40, CD40LG, CD70, CLCF1, CNTF, CNTFR, CRLF2, CSF1, CSF1R, CSF2, CSF2RA, CSF2RB, CSF3, CSF3R, CTF1, CX3CL1, CX3CR1, CXCL1, CXCL10, CXCL11, CXCL12, CXCL13, CXCL14, CXCL16, CXCL2, CXCL3, CXCL5, CXCL6, CXCL9, CXCR3, CXCR4, CXCR6, EDA, EDA2R, EDAR, EGF, EGFR, EPO, EPOR, FAS, FASLG, FLJ78302, FLT1, FLT3, FLT3LG, FLT4, GDF5, GH1, GH2, GHR, HGF, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IFNE1, IFNG, IFNGR1, IFNGR2, IFNK, IFNW1, IL10, IL10RA, IL10RB, IL11, IL11RA, IL12A, IL12B, IL12RB1, IL12RB2, IL13, IL13RA1, IL15, IL15RA, IL17A, IL17B, IL17RA, IL17RB, IL18, IL18R1, IL18RAP, IL19, IL1A, IL1B, IL1R1, IL1R2, IL1RAP, IL2, IL20, IL20RA, IL21, IL21R, IL22, IL22RA1, IL22RA2, IL23A, IL23R, IL24, IL25, IL26, IL28A, IL28B, IL28RA, IL29, IL2RA, IL2RB, IL2RG, IL3, IL3RA, IL4, IL4R, IL5, IL5RA, IL6, IL6R, IL6ST, IL7, IL7R, IL8, IL8RA, IL8RB, IL9, IL9R, INHBA, INHBB, INHBC, INHBE, KDR, KIT, KITLG, LEP, LEPR, LIF, LIFR, LOC728045, LTA, LTB, LTBR, MET, MPL, NGFR, OSM, OSMR, PDGFB, PDGFC, PDGFRA, PDGFRB, PF4, PF4V1, PLEKHO2, PPBP, PRL, PRLR, RELT, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TNF, TNFRSF10A, TNFRSF10B, TNFRSF10C, TNFRSF10D, TNFRSF11A, TNFRSF11B, TNFRSF12A, TNFRSF13B, TNFRSF13C, TNFRSF14, TNFRSF17, TNFRSF18, TNFRSF19, TNFRSF1A, TNFRSF1B, TNFRSF21, TNFRSF25, TNFRSF4, TNFRSF6B, TNFRSF8, TNFRSF9, TNFSF10, TNFSF11, TNFSF12, TNFSF13, TNFSF13B, TNFSF14, TNFSF15, TNFSF18, TNFSF4, TNFSF8, TNFSF9, TPO, TSLP, VEGFA, VEGFB, VEGFC, XCL1, XCL2, XCR1 249 ACVR1(2), ACVR1B(3), ACVR2A(4), ACVR2B(3), AMHR2(16), BMP2(7), BMP7(5), BMPR1A(2), BMPR1B(4), BMPR2(6), CCL1(1), CCL11(3), CCL14(2), CCL15(3), CCL16(2), CCL18(1), CCL2(2), CCL20(2), CCL21(2), CCL22(1), CCL23(1), CCL24(3), CCL25(1), CCL26(2), CCL27(2), CCL28(1), CCL7(4), CCL8(3), CCR1(10), CCR2(17), CCR3(10), CCR4(9), CCR5(10), CCR6(3), CCR7(4), CCR8(8), CCR9(5), CD27(3), CD40(4), CD40LG(2), CLCF1(1), CNTF(2), CNTFR(4), CRLF2(9), CSF1(12), CSF1R(13), CSF2(2), CSF2RA(20), CSF2RB(24), CSF3(4), CSF3R(9), CX3CL1(5), CX3CR1(17), CXCL10(3), CXCL11(1), CXCL12(3), CXCL13(2), CXCL14(3), CXCL3(2), CXCL5(3), CXCL6(2), CXCL9(3), CXCR3(4), CXCR4(3), CXCR6(4), EDA(2), EDA2R(4), EDAR(7), EGF(21), EGFR(25), EPO(5), EPOR(1), FAS(6), FASLG(15), FLT1(38), FLT3(35), FLT3LG(1), FLT4(30), GDF5(16), GH1(3), GH2(10), GHR(40), HGF(29), IFNA1(1), IFNA10(2), IFNA13(1), IFNA14(8), IFNA16(11), IFNA17(2), IFNA2(1), IFNA21(7), IFNA4(1), IFNA5(4), IFNA6(2), IFNA7(6), IFNA8(3), IFNAR1(2), IFNAR2(14), IFNB1(6), IFNG(4), IFNGR1(3), IFNGR2(4), IFNK(2), IFNW1(4), IL10(3), IL10RA(9), IL11(3), IL11RA(3), IL12A(4), IL12B(3), IL12RB1(15), IL12RB2(3), IL13(2), IL13RA1(3), IL15(3), IL15RA(6), IL17A(8), IL17B(4), IL17RA(6), IL17RB(2), IL18(3), IL18R1(21), IL18RAP(26), IL19(2), IL1A(5), IL1B(8), IL1R1(13), IL1R2(8), IL1RAP(3), IL2(4), IL20(4), IL20RA(11), IL21(6), IL21R(18), IL22(2), IL22RA1(12), IL22RA2(3), IL23A(2), IL23R(7), IL25(1), IL26(4), IL28A(1), IL28B(5), IL28RA(4), IL29(1), IL2RA(5), IL2RB(12), IL2RG(3), IL3(3), IL3RA(7), IL4(1), IL4R(16), IL5(4), IL5RA(17), IL6(2), IL6R(3), IL6ST(10), IL7(4), IL7R(34), IL8(1), IL9(1), IL9R(6), INHBA(19), INHBB(9), INHBC(12), INHBE(5), KDR(55), KIT(12), KITLG(11), LEP(4), LEPR(29), LIF(1), LIFR(39), LTA(4), LTB(3), LTBR(1), MET(23), MPL(8), NGFR(8), OSM(5), OSMR(39), PDGFB(6), PDGFC(16), PDGFRA(34), PDGFRB(21), PF4V1(1), PLEKHO2(4), PPBP(5), PRL(3), PRLR(35), RELT(2), TGFB1(2), TGFB2(3), TGFB3(3), TGFBR2(9), TNF(1), TNFRSF10A(7), TNFRSF10B(4), TNFRSF10C(4), TNFRSF10D(9), TNFRSF11A(5), TNFRSF11B(15), TNFRSF12A(1), TNFRSF13B(10), TNFRSF14(3), TNFRSF17(7), TNFRSF18(3), TNFRSF19(2), TNFRSF1A(4), TNFRSF1B(4), TNFRSF21(11), TNFRSF25(6), TNFRSF4(4), TNFRSF6B(4), TNFRSF8(19), TNFRSF9(4), TNFSF10(8), TNFSF11(5), TNFSF13B(2), TNFSF14(9), TNFSF15(8), TNFSF18(9), TNFSF4(5), TNFSF8(3), TNFSF9(4), TPO(47), TSLP(2), VEGFA(4), VEGFB(2), XCL1(1), XCL2(2), XCR1(6) 71733545 1759 245 1677 902 1222 129 45 151 211 1 7.33e-05 1.000 1.000 65 HSA04360_AXON_GUIDANCE Genes involved in axon guidance ABL1, ABLIM1, ABLIM2, ABLIM3, ARHGEF12, CDC42, CDK5, CFL1, CFL2, CHP, CXCL12, CXCR4, DCC, DPYSL2, DPYSL5, EFNA1, EFNA2, EFNA3, EFNA4, EFNA5, EFNB1, EFNB2, EFNB3, EPHA1, EPHA2, EPHA3, EPHA4, EPHA5, EPHA6, EPHA7, EPHA8, EPHB1, EPHB2, EPHB3, EPHB4, EPHB6, FES, FYN, GNAI1, GNAI2, GNAI3, GSK3B, HRAS, ITGB1, KRAS, L1CAM, LIMK1, LIMK2, LRRC4C, MAPK1, MAPK3, MET, NCK1, NCK2, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NGEF, NRAS, NRP1, NTN1, NTN2L, NTN4, NTNG1, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PLXNA1, PLXNA2, PLXNA3, PLXNB1, PLXNB2, PLXNB3, PLXNC1, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PTK2, RAC1, RAC2, RAC3, RASA1, RGS3, RHOA, RHOD, RND1, ROBO1, ROBO2, ROBO3, ROCK1, ROCK2, SEMA3A, SEMA3B, SEMA3C, SEMA3D, SEMA3E, SEMA3F, SEMA3G, SEMA4A, SEMA4B, SEMA4C, SEMA4D, SEMA4F, SEMA4G, SEMA5A, SEMA5B, SEMA6A, SEMA6B, SEMA6C, SEMA6D, SEMA7A, SLIT1, SLIT2, SLIT3, SRGAP1, SRGAP2, SRGAP3, UNC5A, UNC5B, UNC5C, UNC5D 125 ABL1(13), ABLIM1(13), ABLIM2(8), ABLIM3(8), ARHGEF12(12), CDC42(2), CDK5(6), CFL1(2), CXCL12(3), CXCR4(3), DCC(95), DPYSL2(4), DPYSL5(17), EFNA1(1), EFNA2(1), EFNA3(4), EFNA5(4), EFNB1(2), EFNB3(3), EPHA1(22), EPHA2(18), EPHA3(33), EPHA4(21), EPHA5(8), EPHA6(67), EPHA7(52), EPHA8(20), EPHB1(29), EPHB2(34), EPHB3(17), EPHB4(14), EPHB6(27), FES(8), FYN(7), GNAI1(2), GNAI2(6), GNAI3(2), GSK3B(3), HRAS(3), ITGB1(4), KRAS(5), L1CAM(11), LIMK1(5), LIMK2(12), LRRC4C(47), MAPK1(4), MAPK3(4), MET(23), NCK1(2), NCK2(4), NFAT5(8), NFATC1(16), NFATC2(11), NFATC3(10), NFATC4(17), NGEF(12), NRP1(22), NTN4(17), NTNG1(13), PAK1(4), PAK2(7), PAK3(10), PAK4(8), PAK6(6), PAK7(55), PLXNA1(12), PLXNA2(9), PLXNA3(16), PLXNB1(22), PLXNB2(16), PLXNB3(6), PLXNC1(17), PPP3CA(5), PPP3CB(3), PPP3CC(2), PPP3R2(5), PTK2(7), RAC2(3), RASA1(4), RGS3(16), RHOA(2), RHOD(2), RND1(5), ROBO1(24), ROBO2(43), ROBO3(20), ROCK1(7), ROCK2(11), SEMA3A(13), SEMA3B(2), SEMA3C(2), SEMA3D(12), SEMA3E(28), SEMA3F(11), SEMA3G(15), SEMA4A(9), SEMA4B(4), SEMA4C(12), SEMA4D(10), SEMA4F(7), SEMA4G(8), SEMA5A(18), SEMA5B(20), SEMA6A(9), SEMA6B(8), SEMA6C(8), SEMA6D(6), SEMA7A(4), SLIT1(17), SLIT2(62), SLIT3(60), SRGAP1(6), SRGAP2(8), SRGAP3(39), UNC5A(11), UNC5B(10), UNC5C(17), UNC5D(32) 79241929 1656 236 1552 835 1132 133 47 164 177 3 0.000192 1.000 1.000 66 HSA04530_TIGHT_JUNCTION Genes involved in tight junction ACTB, ACTG1, ACTN1, ACTN2, ACTN3, ACTN4, AKT1, AKT2, AKT3, AMOTL1, ASH1L, CASK, CDC42, CDK4, CGN, CLDN1, CLDN10, CLDN11, CLDN14, CLDN15, CLDN16, CLDN17, CLDN18, CLDN19, CLDN2, CLDN20, CLDN22, CLDN23, CLDN3, CLDN4, CLDN5, CLDN6, CLDN7, CLDN8, CLDN9, CRB3, CSDA, CSNK2A1, CSNK2A2, CSNK2B, CTNNA1, CTNNA2, CTNNA3, CTNNB1, CTTN, EPB41, EPB41L1, EPB41L2, EPB41L3, EXOC3, EXOC4, F11R, GNAI1, GNAI2, GNAI3, HCLS1, HRAS, IGSF5, INADL, JAM2, JAM3, KRAS, LLGL1, LLGL2, MAGI1, MAGI2, MAGI3, MLLT4, MPDZ, MPP5, MRAS, MRCL3, MRLC2, MYH1, MYH10, MYH11, MYH13, MYH14, MYH15, MYH2, MYH3, MYH4, MYH6, MYH7, MYH7B, MYH8, MYH9, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLPF, NRAS, OCLN, PARD3, PARD6A, PARD6B, PARD6G, PPM1J, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, PPP2R3A, PPP2R3B, PPP2R4, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCI, PRKCQ, PRKCZ, PTEN, RAB13, RAB3B, RHOA, RRAS, RRAS2, SPTAN1, SRC, SYMPK, TJAP1, TJP1, TJP2, TJP3, VAPA, YES1, ZAK 129 ACTB(8), ACTG1(6), ACTN1(8), ACTN2(20), ACTN3(3), ACTN4(5), AKT1(4), AKT2(8), AKT3(3), AMOTL1(3), ASH1L(34), CASK(7), CDC42(2), CDK4(7), CGN(10), CLDN1(5), CLDN10(7), CLDN11(5), CLDN14(5), CLDN15(1), CLDN16(7), CLDN17(5), CLDN18(8), CLDN19(2), CLDN2(6), CLDN20(1), CLDN22(1), CLDN3(2), CLDN4(11), CLDN6(8), CLDN7(1), CLDN8(4), CLDN9(1), CSDA(4), CSNK2A1(4), CSNK2A2(1), CSNK2B(2), CTNNA1(3), CTNNA2(30), CTNNA3(38), CTNNB1(14), CTTN(4), EPB41(8), EPB41L1(13), EPB41L2(19), EPB41L3(6), EXOC3(6), EXOC4(11), F11R(7), GNAI1(2), GNAI2(6), GNAI3(2), HCLS1(13), HRAS(3), IGSF5(11), INADL(40), JAM2(11), JAM3(3), KRAS(5), LLGL1(5), LLGL2(14), MAGI1(31), MAGI2(24), MAGI3(13), MLLT4(16), MPDZ(13), MPP5(1), MRAS(2), MYH1(101), MYH10(14), MYH11(31), MYH13(52), MYH14(23), MYH15(64), MYH2(97), MYH3(30), MYH4(96), MYH6(37), MYH7(56), MYH7B(26), MYH8(64), MYH9(11), MYL2(9), MYL5(1), MYL7(3), MYL9(2), MYLPF(2), OCLN(7), PARD3(18), PARD6A(1), PARD6B(2), PARD6G(3), PPM1J(1), PPP2CB(2), PPP2R1A(4), PPP2R1B(3), PPP2R2B(6), PPP2R2C(8), PPP2R3A(10), PPP2R3B(5), PPP2R4(2), PRKCA(8), PRKCD(5), PRKCE(6), PRKCG(16), PRKCH(9), PRKCI(8), PRKCQ(20), PRKCZ(7), RAB3B(1), RHOA(2), RRAS(1), RRAS2(1), SPTAN1(10), SRC(2), SYMPK(7), TJAP1(5), TJP1(13), TJP2(10), TJP3(20), VAPA(2), YES1(4) 78321911 1541 233 1439 934 1043 133 42 140 178 5 0.168 1.000 1.000 67 CALCIUM_REGULATION_IN_CARDIAC_CELLS ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADRA1A, ADRA1B, ADRA1D, ADRB1, ADRB2, ADRB3, ANXA6, ARRB1, ARRB2, ATP1A4, ATP1B1, ATP1B2, ATP1B3, ATP2A2, ATP2A3, ATP2B1, ATP2B2, ATP2B3, CACNA1A, CACNA1B, CACNA1C, CACNA1D, CACNA1E, CACNA1S, CACNB1, CACNB3, CALM1, CALM2, CALM3, CALR, CAMK1, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CASQ1, CASQ2, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, FXYD2, GJA1, GJA12, GJA4, GJA5, GJB1, GJB2, GJB3, GJB4, GJB5, GJB6, GNA11, GNAI2, GNAI3, GNAO1, GNAQ, GNAZ, GNB1, GNB2, GNB3, GNB4, GNB5, GNG12, GNG13, GNG2, GNG3, GNG4, GNG5, GNG7, GNGT1, GRK4, GRK5, GRK6, ITPR1, ITPR2, ITPR3, KCNB1, KCNJ3, KCNJ5, MGC11266, MYCBP, NME7, PEA15, PKIA, PKIB, PKIG, PLCB3, PLN, PRKACA, PRKACB, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCQ, PRKCZ, PRKD1, RGS1, RGS10, RGS11, RGS14, RGS16, RGS17, RGS18, RGS19, RGS2, RGS20, RGS3, RGS4, RGS5, RGS6, RGS7, RGS9, RYR1, RYR2, RYR3, SARA1, SFN, SLC8A1, SLC8A3, USP5, YWHAB, YWHAH, YWHAQ, YWHAQ, MIB1 139 ADCY1(34), ADCY2(10), ADCY3(3), ADCY4(5), ADCY5(19), ADCY6(9), ADCY7(11), ADCY8(55), ADCY9(10), ADRA1A(9), ADRA1B(4), ADRA1D(5), ADRB1(5), ADRB2(3), ANXA6(5), ARRB1(5), ARRB2(6), ATP1A4(15), ATP1B1(2), ATP1B3(1), ATP2A2(13), ATP2A3(15), ATP2B1(7), ATP2B2(28), ATP2B3(9), CACNA1A(38), CACNA1B(35), CACNA1C(62), CACNA1D(33), CACNA1E(111), CACNA1S(53), CACNB1(4), CACNB3(2), CALM1(1), CALM2(1), CALR(2), CAMK1(5), CAMK2A(6), CAMK2B(6), CAMK2D(6), CAMK2G(5), CAMK4(17), CASQ1(7), CASQ2(4), CHRM1(5), CHRM2(25), CHRM3(26), CHRM4(6), CHRM5(7), GJA1(9), GJA4(4), GJA5(10), GJB1(1), GJB2(3), GJB3(4), GJB4(8), GJB5(8), GJB6(6), GNA11(8), GNAI2(6), GNAI3(2), GNAO1(2), GNAQ(6), GNAZ(7), GNB1(1), GNB2(1), GNB3(7), GNB4(4), GNB5(2), GNG2(3), GNG4(3), GNG7(2), GRK4(10), GRK5(6), GRK6(2), ITPR1(36), ITPR2(20), ITPR3(11), KCNB1(38), KCNJ3(20), KCNJ5(13), MIB1(6), NME7(4), PKIA(3), PKIB(1), PKIG(1), PLCB3(4), PRKACA(3), PRKACB(4), PRKAR1A(3), PRKAR1B(4), PRKAR2A(1), PRKAR2B(5), PRKCA(8), PRKCD(5), PRKCE(6), PRKCG(16), PRKCH(9), PRKCQ(20), PRKCZ(7), PRKD1(9), RGS1(5), RGS11(4), RGS14(3), RGS16(3), RGS18(8), RGS2(1), RGS20(2), RGS3(16), RGS4(5), RGS5(4), RGS6(20), RGS7(38), RGS9(14), RYR1(109), RYR2(99), RYR3(90), SLC8A1(34), SLC8A3(43), USP5(7), YWHAB(1), YWHAQ(3) 75800340 1646 231 1556 1093 1131 146 70 120 175 4 0.118 1.000 1.000 68 SMOOTH_MUSCLE_CONTRACTION ACTA1, ACTA2, ACTC, ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADM, ADMR, ARRB1, ARRB2, ATF1, ATF2, ATF3, ATF4, ATF5, ATP2A2, ATP2A3, CACNB3, CALCA, CALM1, CALM2, CALM3, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CMKOR1, CNN1, CNN2, CORIN, CREB3, CREBL1, CREBL1, TNXB, CRH, CRHR1, DGKZ, EDG2, ETS2, FOS, GABPA, GABPB2, GBA2, GJA1, GNAQ, GNB1, GNB2, GNB3, GNB4, GNB5, GNG12, GNG13, GNG2, GNG3, GNG4, GNG5, GNG7, GNGT1, GRK4, GRK5, GRK6, GSTO1, GUCA2A, GUCA2B, GUCY1A3, HEAB, IGFBP1, IGFBP2, IGFBP3, IGFBP4, IGFBP6, IL1B, IL6, ITPR1, ITPR2, ITPR3, JUN, LGR7, LGR8, MAFF, MGC11266, MYL2, MYL4, MYLK2, NFKB1, NOS1, NOS3, OXT, OXTR, PDE4B, PDE4D, PKIA, PKIB, PKIG, PLCB3, PLCD1, PLCG1, PLCG2, PRKACA, PRKACB, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCH, PRKCQ, PRKCZ, PRKD1, RAMP1, RAMP2, RAMP3, RCP9, RGS1, RGS10, RGS11, RGS14, RGS16, RGS17, RGS18, RGS19, RGS2, RGS20, RGS3, RGS4, RGS5, RGS6, RGS7, RGS9, RLN1, RYR1, RYR2, RYR3, SARA1, SFN, SLC8A1, SP1, USP5, YWHAB, YWHAH, YWHAQ, YWHAQ, MIB1 138 ACTA1(4), ACTA2(5), ADCY1(34), ADCY2(10), ADCY3(3), ADCY4(5), ADCY5(19), ADCY6(9), ADCY7(11), ADCY8(55), ADCY9(10), ARRB1(5), ARRB2(6), ATF1(4), ATF2(6), ATF3(1), ATF4(9), ATF5(9), ATP2A2(13), ATP2A3(15), CACNB3(2), CALCA(4), CALM1(1), CALM2(1), CAMK2A(6), CAMK2B(6), CAMK2D(6), CAMK2G(5), CNN1(6), CNN2(3), CORIN(27), CREB3(1), CRH(3), CRHR1(7), DGKZ(6), ETS2(8), FOS(2), GABPA(5), GABPB2(8), GBA2(2), GJA1(9), GNAQ(6), GNB1(1), GNB2(1), GNB3(7), GNB4(4), GNB5(2), GNG2(3), GNG4(3), GNG7(2), GRK4(10), GRK5(6), GRK6(2), GSTO1(3), GUCA2A(2), GUCA2B(2), GUCY1A3(32), IGFBP1(4), IGFBP2(2), IGFBP3(2), IGFBP6(2), IL1B(8), IL6(2), ITPR1(36), ITPR2(20), ITPR3(11), JUN(1), MIB1(6), MYL2(9), MYL4(6), MYLK2(12), NFKB1(6), NOS1(74), NOS3(19), OXTR(5), PDE4B(8), PDE4D(7), PKIA(3), PKIB(1), PKIG(1), PLCB3(4), PLCD1(4), PLCG1(8), PLCG2(27), PRKACA(3), PRKACB(4), PRKAR1A(3), PRKAR1B(4), PRKAR2A(1), PRKAR2B(5), PRKCA(8), PRKCD(5), PRKCE(6), PRKCH(9), PRKCQ(20), PRKCZ(7), PRKD1(9), RAMP1(1), RAMP2(1), RAMP3(2), RGS1(5), RGS11(4), RGS14(3), RGS16(3), RGS18(8), RGS2(1), RGS20(2), RGS3(16), RGS4(5), RGS5(4), RGS6(20), RGS7(38), RGS9(14), RLN1(3), RYR1(109), RYR2(99), RYR3(90), SLC8A1(34), SP1(5), TNXB(128), USP5(7), YWHAB(1), YWHAQ(3) 70719641 1415 228 1341 803 976 116 54 105 161 3 0.000929 1.000 1.000 69 STRIATED_MUSCLE_CONTRACTION ACTA1, ACTA2, ACTC, ACTN2, ACTN3, ACTN4, C9orf97, DES, DES, FAM48A, DMD, MYBPC1, MYBPC2, MYBPC3, MYH3, MYH6, MYH6, MYH7, MYH8, MYL1, MYL2, MYL3, MYL4, MYL9, MYOM1, NEB, TCAP, TMOD1, TNNC2, TNNI1, TNNI2, TNNI3, TNNT1, TNNT2, TNNT3, TPM1, TPM2, TPM3, TPM4, TPM4, TTN, VIM 37 ACTA1(4), ACTA2(5), ACTN2(20), ACTN3(3), ACTN4(5), DES(9), DMD(39), FAM48A(2), MYBPC1(26), MYBPC2(20), MYBPC3(16), MYH3(30), MYH6(37), MYH7(56), MYH8(64), MYL1(12), MYL2(9), MYL3(2), MYL4(6), MYL9(2), MYOM1(24), NEB(129), TNNC2(4), TNNI1(1), TNNI2(2), TNNI3(2), TNNT1(3), TNNT2(5), TNNT3(5), TPM1(4), TPM2(3), TPM3(2), TPM4(3), TTN(1050), VIM(5) 54246466 1609 226 1480 694 1165 111 54 142 122 15 2.22e-07 1.000 1.000 70 HSA04514_CELL_ADHESION_MOLECULES Genes involved in cell adhesion molecules (CAMs) ALCAM, CADM1, CADM3, CD2, CD22, CD226, CD274, CD276, CD28, CD34, CD4, CD40, CD40LG, CD58, CD6, CD80, CD86, CD8A, CD8B, CD99, CDH1, CDH15, CDH2, CDH3, CDH4, CDH5, CLDN1, CLDN10, CLDN11, CLDN14, CLDN15, CLDN16, CLDN17, CLDN18, CLDN19, CLDN2, CLDN20, CLDN22, CLDN23, CLDN3, CLDN4, CLDN5, CLDN6, CLDN7, CLDN8, CLDN9, CNTN1, CNTN2, CNTNAP1, CNTNAP2, CTLA4, ESAM, F11R, GLG1, HLA-A, HLA-A29.1, HLA-B, HLA-C, HLA-DMA, HLA-DMB, HLA-DOA, HLA-DOB, HLA-DPA1, HLA-DPB1, HLA-DQA1, HLA-DQA2, HLA-DQB1, HLA-DQB2, HLA-DRA, HLA-DRB1, HLA-DRB3, HLA-DRB4, HLA-DRB5, HLA-E, HLA-F, HLA-G, ICAM1, ICAM2, ICAM3, ICOS, ICOSLG, ITGA4, ITGA6, ITGA8, ITGA9, ITGAL, ITGAM, ITGAV, ITGB1, ITGB2, ITGB7, ITGB8, JAM2, JAM3, L1CAM, MADCAM1, MAG, MPZ, MPZL1, NCAM1, NCAM2, NEGR1, NEO1, NFASC, NLGN1, NLGN2, NLGN3, NRCAM, NRXN1, NRXN2, NRXN3, OCLN, PDCD1, PDCD1LG2, PECAM1, PTPRC, PTPRF, PTPRM, PVR, PVRL1, PVRL2, PVRL3, SDC1, SDC2, SDC3, SDC4, SELE, SELL, SELP, SELPLG, SIGLEC1, SPN, VCAM1, VCAN 130 ALCAM(7), CADM1(4), CADM3(19), CD2(27), CD22(23), CD226(6), CD274(1), CD276(7), CD28(2), CD34(4), CD4(8), CD40(4), CD40LG(2), CD58(1), CD6(12), CD80(4), CD86(25), CD8A(2), CD8B(7), CD99(1), CDH1(5), CDH15(8), CDH2(14), CDH4(38), CDH5(11), CLDN1(5), CLDN10(7), CLDN11(5), CLDN14(5), CLDN15(1), CLDN16(7), CLDN17(5), CLDN18(8), CLDN19(2), CLDN2(6), CLDN20(1), CLDN22(1), CLDN3(2), CLDN4(11), CLDN6(8), CLDN7(1), CLDN8(4), CLDN9(1), CNTN1(26), CNTN2(16), CNTNAP1(12), CNTNAP2(88), CTLA4(2), ESAM(5), F11R(7), GLG1(6), HLA-A(3), HLA-C(9), HLA-DMA(7), HLA-DMB(7), HLA-DOA(5), HLA-DPA1(2), HLA-DPB1(2), HLA-DQA1(7), HLA-DQA2(7), HLA-DQB1(5), HLA-DRA(12), HLA-DRB5(6), HLA-E(1), HLA-F(4), HLA-G(6), ICAM1(2), ICAM2(4), ICAM3(3), ICOS(2), ICOSLG(2), ITGA4(43), ITGA6(10), ITGA8(37), ITGA9(13), ITGAL(28), ITGAM(23), ITGAV(9), ITGB1(4), ITGB2(16), ITGB7(6), ITGB8(20), JAM2(11), JAM3(3), L1CAM(11), MADCAM1(1), MAG(12), MPZ(3), MPZL1(1), NCAM1(14), NCAM2(10), NEGR1(8), NEO1(13), NFASC(30), NLGN1(12), NLGN2(7), NLGN3(6), NRCAM(10), NRXN1(54), NRXN2(19), NRXN3(32), OCLN(7), PDCD1(4), PDCD1LG2(4), PTPRC(35), PTPRF(32), PTPRM(7), PVR(3), PVRL1(3), PVRL2(6), PVRL3(5), SDC1(3), SDC2(2), SDC3(7), SDC4(3), SELE(33), SELL(10), SELP(39), SELPLG(10), SIGLEC1(32), SPN(5), VCAM1(17), VCAN(42) 59717625 1355 224 1278 638 932 92 49 133 149 0 2.16e-06 1.000 1.000 71 HSA04630_JAK_STAT_SIGNALING_PATHWAY Genes involved in Jak-STAT signaling pathway AKT1, AKT2, AKT3, BCL2L1, CBL, CBLB, CBLC, CCND1, CCND2, CCND3, CISH, CLCF1, CNTF, CNTFR, CREBBP, CRLF2, CSF2, CSF2RA, CSF2RB, CSF3, CSF3R, CTF1, EP300, EPO, EPOR, GH1, GH2, GHR, GRB2, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IFNE1, IFNG, IFNGR1, IFNGR2, IFNK, IFNW1, IL10, IL10RA, IL10RB, IL11, IL11RA, IL12A, IL12B, IL12RB1, IL12RB2, IL13, IL13RA1, IL13RA2, IL15, IL15RA, IL19, IL2, IL20, IL20RA, IL21, IL21R, IL22, IL22RA1, IL22RA2, IL23A, IL23R, IL24, IL26, IL28A, IL28B, IL28RA, IL29, IL2RA, IL2RB, IL2RG, IL3, IL3RA, IL4, IL4R, IL5, IL5RA, IL6, IL6R, IL6ST, IL7, IL7R, IL9, IL9R, IRF9, JAK1, JAK2, JAK3, LEP, LEPR, LIF, LIFR, MPL, MYC, OSM, OSMR, PIAS1, PIAS2, PIAS3, PIAS4, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIM1, PRL, PRLR, PTPN11, PTPN6, SOCS1, SOCS2, SOCS3, SOCS4, SOCS5, SOCS7, SOS1, SOS2, SPRED1, SPRED2, SPRY1, SPRY2, SPRY3, SPRY4, STAM, STAM2, STAT1, STAT2, STAT3, STAT4, STAT5A, STAT5B, STAT6, TPO, TSLP, TYK2 151 AKT1(4), AKT2(8), AKT3(3), CBL(10), CBLB(21), CBLC(15), CCND1(2), CCND2(6), CCND3(2), CISH(4), CLCF1(1), CNTF(2), CNTFR(4), CREBBP(24), CRLF2(9), CSF2(2), CSF2RA(20), CSF2RB(24), CSF3(4), CSF3R(9), EP300(18), EPO(5), EPOR(1), GH1(3), GH2(10), GHR(40), GRB2(2), IFNA1(1), IFNA10(2), IFNA13(1), IFNA14(8), IFNA16(11), IFNA17(2), IFNA2(1), IFNA21(7), IFNA4(1), IFNA5(4), IFNA6(2), IFNA7(6), IFNA8(3), IFNAR1(2), IFNAR2(14), IFNB1(6), IFNG(4), IFNGR1(3), IFNGR2(4), IFNK(2), IFNW1(4), IL10(3), IL10RA(9), IL11(3), IL11RA(3), IL12A(4), IL12B(3), IL12RB1(15), IL12RB2(3), IL13(2), IL13RA1(3), IL13RA2(5), IL15(3), IL15RA(6), IL19(2), IL2(4), IL20(4), IL20RA(11), IL21(6), IL21R(18), IL22(2), IL22RA1(12), IL22RA2(3), IL23A(2), IL23R(7), IL26(4), IL28A(1), IL28B(5), IL28RA(4), IL29(1), IL2RA(5), IL2RB(12), IL2RG(3), IL3(3), IL3RA(7), IL4(1), IL4R(16), IL5(4), IL5RA(17), IL6(2), IL6R(3), IL6ST(10), IL7(4), IL7R(34), IL9(1), IL9R(6), IRF9(2), JAK1(6), JAK2(8), JAK3(11), LEP(4), LEPR(29), LIF(1), LIFR(39), MPL(8), MYC(5), OSM(5), OSMR(39), PIAS1(5), PIAS2(5), PIAS3(6), PIAS4(1), PIK3CA(10), PIK3CB(14), PIK3CD(8), PIK3CG(27), PIK3R1(2), PIK3R2(5), PIK3R3(2), PIK3R5(16), PIM1(1), PRL(3), PRLR(35), PTPN11(10), PTPN6(5), SOCS1(1), SOCS2(2), SOCS3(1), SOCS4(3), SOCS5(8), SOCS7(5), SOS1(10), SOS2(13), SPRED1(5), SPRED2(4), SPRY1(9), SPRY2(4), SPRY3(12), SPRY4(2), STAM(3), STAM2(3), STAT1(5), STAT2(6), STAT3(9), STAT4(26), STAT5A(3), STAT5B(6), STAT6(8), TPO(47), TSLP(2), TYK2(8) 59303902 1134 224 1087 525 744 92 37 117 142 2 0.00231 1.000 1.000 72 GPCRDB_CLASS_A_RHODOPSIN_LIKE ADORA1, ADORA2A, ADORA2B, ADORA3, ADRA1A, ADRA1B, ADRA1D, ADRA2A, ADRA2C, ADRB1, ADRB2, ADRB3, AGTR1, AGTR2, AGTRL1, AVPR1A, AVPR1B, AVPR2, BDKRB1, BDKRB2, BLR1, BRS3, C3AR1, C5R1, CCBP2, CCKAR, CCKBR, CCR1, CCR10, CCR2, CCR3, CCR4, CCR5, CCR6, CCR7, CCR8, CCR9, CCRL1, CCRL2, CHML, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, CMKLR1, CMKOR1, CNR1, CNR2, CX3CR1, CXCR3, CXCR4, DRD1, DRD2, DRD3, DRD4, DRD5, EDNRA, EDNRB, ELA3A, F2R, F2RL1, F2RL2, F2RL3, FPR1, FPRL1, FPRL2, FSHR, GALR1, GALR2, GALR3, GALT, GHSR, GNB2L1, GPR10, GPR147, GPR17, GPR173, GPR174, GPR23, GPR24, GPR27, GPR3, GPR30, GPR35, GPR37, GPR37L1, GPR4, GPR44, GPR50, GPR6, GPR63, GPR74, GPR77, GPR83, GPR85, GPR87, GPR92, GRPR, HCRTR1, HCRTR2, HRH1, HRH2, HRH3, HTR1A, HTR1B, HTR1D, HTR1E, HTR1F, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, HTR7, LOC93164, IL8RA, IL8RB, LHCGR, LTB4R, MAS1, MC1R, MC3R, MC4R, MC5R, MLNR, MTNR1A, MTNR1B, NMBR, NMUR1, NMUR2, NPY1R, NPY2R, NPY5R, NPY6R, NTSR1, NTSR2, OPN1SW, OPN3, OPRD1, OPRK1, OPRL1, OPRM1, OR10A5, OR11A1, OR12D3, OR1C1, OR1F1, OR1Q1, OR2H1, OR5V1, OR5V1, OR12D3, OR7A5, OR7C1, OR8B8, OXTR, P2RY1, P2RY10, P2RY11, P2RY12, P2RY13, P2RY14, P2RY2, P2RY5, P2RY6, PPYR1, PTAFR, PTGDR, PTGER1, PTGER2, PTGER4, PTGFR, PTGIR, Rgr, RGR, RHO, RRH, SSTR1, SSTR2, SSTR3, SSTR4, SUCNR1, TBXA2R, TRHR 162 ADORA1(6), ADORA2A(3), ADORA2B(1), ADORA3(15), ADRA1A(9), ADRA1B(4), ADRA1D(5), ADRA2A(3), ADRA2C(2), ADRB1(5), ADRB2(3), AGTR1(10), AGTR2(9), AVPR1A(4), AVPR1B(11), BDKRB1(6), BDKRB2(9), BRS3(5), C3AR1(5), CCBP2(10), CCKAR(11), CCKBR(11), CCR1(10), CCR10(3), CCR2(17), CCR3(10), CCR4(9), CCR5(10), CCR6(3), CCR7(4), CCR8(8), CCR9(5), CCRL2(6), CHML(5), CHRM1(5), CHRM2(25), CHRM3(26), CHRM4(6), CHRM5(7), CMKLR1(15), CNR1(13), CNR2(5), CX3CR1(17), CXCR3(4), CXCR4(3), DRD1(9), DRD2(14), DRD3(6), DRD4(1), DRD5(25), EDNRA(10), EDNRB(7), F2R(8), F2RL1(16), F2RL2(8), F2RL3(4), FPR1(21), FSHR(19), GALR1(5), GALR3(2), GALT(2), GHSR(11), GNB2L1(4), GPR17(1), GPR173(1), GPR174(12), GPR27(2), GPR3(3), GPR35(6), GPR37(9), GPR37L1(7), GPR4(4), GPR50(19), GPR6(7), GPR63(9), GPR77(6), GPR83(13), GPR85(5), GPR87(6), GRPR(7), HCRTR1(2), HCRTR2(33), HRH1(14), HRH2(3), HRH3(5), HTR1A(10), HTR1B(1), HTR1D(6), HTR1E(7), HTR1F(9), HTR2A(11), HTR2B(2), HTR2C(13), HTR4(9), HTR5A(19), HTR6(1), HTR7(9), LHCGR(27), LTB4R(1), MAS1(4), MC3R(7), MC4R(1), MC5R(8), MLNR(1), MTNR1A(10), MTNR1B(8), NMBR(7), NMUR1(8), NMUR2(16), NPY1R(29), NPY2R(13), NPY5R(24), NTSR1(7), NTSR2(2), OPN1SW(3), OPN3(4), OPRD1(3), OPRK1(24), OPRL1(8), OPRM1(5), OR10A5(9), OR11A1(6), OR12D3(9), OR1C1(13), OR1F1(8), OR1Q1(6), OR2H1(9), OR5V1(12), OR7A5(2), OR7C1(2), OR8B8(14), OXTR(5), P2RY1(5), P2RY10(7), P2RY12(4), P2RY13(4), P2RY14(8), P2RY2(8), P2RY6(2), PPYR1(14), PTAFR(2), PTGDR(11), PTGER2(7), PTGER4(2), PTGFR(21), PTGIR(5), RGR(5), RHO(2), RRH(2), SSTR1(10), SSTR2(7), SSTR3(11), SSTR4(4), SUCNR1(11), TBXA2R(4), TRHR(23) 49438492 1300 223 1213 970 875 135 47 143 100 0 0.000855 1.000 1.000 73 HSA04310_WNT_SIGNALING_PATHWAY Genes involved in Wnt signaling pathway APC, APC2, AXIN1, AXIN2, BTRC, CACYBP, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CCND1, CCND2, CCND3, CER1, CHD8, CHP, CREBBP, CSNK1A1, CSNK1A1L, CSNK1E, CSNK2A1, CSNK2A2, CSNK2B, CTBP1, CTBP2, CTNNB1, CTNNBIP1, CUL1, CXXC4, DAAM1, DAAM2, DKK1, DKK2, DKK4, DVL1, DVL2, DVL3, EP300, FBXW11, FOSL1, FRAT1, FRAT2, FZD1, FZD10, FZD2, FZD3, FZD4, FZD5, FZD6, FZD7, FZD8, FZD9, GSK3B, JUN, LEF1, LOC652788, LRP5, LRP6, MAP3K7, MAPK10, MAPK8, MAPK9, MMP7, MYC, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NKD1, NKD2, NLK, PLCB1, PLCB2, PLCB3, PLCB4, PORCN, PPARD, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRICKLE1, PRICKLE2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, PSEN1, RAC1, RAC2, RAC3, RBX1, RHOA, ROCK1, ROCK2, RUVBL1, SENP2, SFRP1, SFRP2, SFRP4, SFRP5, SIAH1, SKP1, SMAD2, SMAD3, SMAD4, SOX17, TBL1X, TBL1XR1, TBL1Y, TCF7, TCF7L1, TCF7L2, TP53, VANGL1, VANGL2, WIF1, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT3A, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B, WNT8A, WNT8B, WNT9A, WNT9B 142 APC(25), APC2(12), AXIN1(9), AXIN2(4), BTRC(4), CACYBP(2), CAMK2A(6), CAMK2B(6), CAMK2D(6), CAMK2G(5), CCND1(2), CCND2(6), CCND3(2), CER1(16), CHD8(27), CREBBP(24), CSNK1A1(3), CSNK1A1L(7), CSNK1E(5), CSNK2A1(4), CSNK2A2(1), CSNK2B(2), CTBP2(1), CTNNB1(14), CTNNBIP1(1), CUL1(5), DAAM1(7), DAAM2(7), DKK1(2), DKK2(19), DKK4(3), DVL2(3), DVL3(8), EP300(18), FBXW11(6), FZD1(5), FZD10(4), FZD2(6), FZD3(1), FZD4(1), FZD5(2), FZD6(2), FZD7(4), FZD8(5), FZD9(1), GSK3B(3), JUN(1), LEF1(3), LRP5(20), LRP6(29), MAP3K7(1), MAPK10(9), MAPK8(1), MAPK9(3), MMP7(4), MYC(5), NFAT5(8), NFATC1(16), NFATC2(11), NFATC3(10), NFATC4(17), NKD1(8), NKD2(7), NLK(5), PLCB1(54), PLCB2(12), PLCB3(4), PLCB4(86), PORCN(4), PPARD(3), PPP2CB(2), PPP2R1A(4), PPP2R1B(3), PPP2R2B(6), PPP2R2C(8), PPP3CA(5), PPP3CB(3), PPP3CC(2), PPP3R2(5), PRICKLE1(9), PRICKLE2(6), PRKACA(3), PRKACB(4), PRKACG(11), PRKCA(8), PRKCG(16), PRKX(3), PSEN1(1), RAC2(3), RHOA(2), ROCK1(7), ROCK2(11), RUVBL1(1), SENP2(14), SFRP1(3), SFRP2(9), SFRP4(5), SFRP5(1), SMAD2(3), SMAD3(4), SMAD4(1), SOX17(8), TBL1X(4), TBL1XR1(1), TBL1Y(9), TCF7(1), TCF7L1(4), TCF7L2(7), VANGL1(3), VANGL2(8), WIF1(7), WNT1(2), WNT10A(7), WNT10B(6), WNT11(4), WNT16(3), WNT2(8), WNT2B(5), WNT3(5), WNT3A(9), WNT4(1), WNT5A(5), WNT5B(4), WNT6(3), WNT7A(14), WNT7B(6), WNT8A(7), WNT8B(7), WNT9A(3), WNT9B(6) 64975168 947 221 909 460 586 83 40 116 120 2 0.0313 1.000 1.000 74 HSA04540_GAP_JUNCTION Genes involved in gap junction ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADRB1, CDC2, CSNK1D, DRD1, DRD2, EDG2, EGF, EGFR, GJA1, GJD2, GNA11, GNAI1, GNAI2, GNAI3, GNAQ, GNAS, GRB2, GRM1, GRM5, GUCY1A2, GUCY1A3, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, HRAS, HTR2A, HTR2B, HTR2C, ITPR1, ITPR2, ITPR3, KRAS, LOC643224, LOC654264, MAP2K1, MAP2K2, MAP2K5, MAP3K2, MAPK1, MAPK3, MAPK7, NPR1, NPR2, NRAS, PDGFA, PDGFB, PDGFC, PDGFD, PDGFRA, PDGFRB, PLCB1, PLCB2, PLCB3, PLCB4, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKG1, PRKG2, PRKX, PRKY, RAF1, SOS1, SOS2, SRC, TJP1, TUBA1A, TUBA1B, TUBA1C, TUBA3C, TUBA3D, TUBA3E, TUBA4A, TUBA8, TUBAL3, TUBB, TUBB1, TUBB2A, TUBB2B, TUBB2C, TUBB3, TUBB4, TUBB4Q, TUBB6, TUBB8 91 ADCY1(34), ADCY2(10), ADCY3(3), ADCY4(5), ADCY5(19), ADCY6(9), ADCY7(11), ADCY8(55), ADCY9(10), ADRB1(5), CSNK1D(3), DRD1(9), DRD2(14), EGF(21), EGFR(25), GJA1(9), GJD2(5), GNA11(8), GNAI1(2), GNAI2(6), GNAI3(2), GNAQ(6), GNAS(25), GRB2(2), GRM1(16), GRM5(15), GUCY1A2(21), GUCY1A3(32), GUCY1B3(7), GUCY2C(38), GUCY2D(9), GUCY2F(23), HRAS(3), HTR2A(11), HTR2B(2), HTR2C(13), ITPR1(36), ITPR2(20), ITPR3(11), KRAS(5), MAP2K1(14), MAP2K2(5), MAP2K5(4), MAP3K2(6), MAPK1(4), MAPK3(4), MAPK7(4), NPR1(18), NPR2(20), PDGFA(1), PDGFB(6), PDGFC(16), PDGFD(6), PDGFRA(34), PDGFRB(21), PLCB1(54), PLCB2(12), PLCB3(4), PLCB4(86), PRKACA(3), PRKACB(4), PRKACG(11), PRKCA(8), PRKCG(16), PRKG1(14), PRKG2(16), PRKX(3), RAF1(10), SOS1(10), SOS2(13), SRC(2), TJP1(13), TUBA1A(4), TUBA1B(4), TUBA1C(1), TUBA3C(23), TUBA3D(13), TUBA3E(4), TUBA4A(7), TUBA8(5), TUBAL3(11), TUBB(1), TUBB1(4), TUBB2A(2), TUBB3(4), TUBB6(10), TUBB8(12) 53451485 1107 219 1031 604 749 85 45 107 119 2 0.00107 1.000 1.000 75 HSA04910_INSULIN_SIGNALING_PATHWAY Genes involved in insulin signaling pathway ACACA, ACACB, AKT1, AKT2, AKT3, ARAF, BAD, BRAF, CALM1, CALM2, CALM3, CALML3, CALML6, CBL, CBLB, CBLC, CRK, CRKL, EIF4EBP1, ELK1, EXOC7, FASN, FBP1, FBP2, FLOT1, FLOT2, FOXO1, FRAP1, G6PC, G6PC2, GCK, GRB2, GSK3B, GYS1, GYS2, HRAS, IKBKB, INPP5D, INS, INSR, IRS1, IRS2, IRS4, KIAA1303, KRAS, LIPE, MAP2K1, MAP2K2, MAPK1, MAPK10, MAPK3, MAPK8, MAPK9, MKNK1, MKNK2, NRAS, PCK1, PCK2, PDE3A, PDE3B, PDPK1, PFKL, PFKM, PFKP, PHKA1, PHKA2, PHKB, PHKG1, PHKG2, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PKLR, PKM2, PPARGC1A, PPP1CA, PPP1CB, PPP1CC, PPP1R3A, PPP1R3B, PPP1R3C, PPP1R3D, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKACA, PRKACB, PRKACG, PRKAG1, PRKAG2, PRKAG3, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCI, PRKCZ, PRKX, PRKY, PTPN1, PTPRF, PYGB, PYGL, PYGM, RAF1, RAPGEF1, RHEB, RHOQ, RPS6, RPS6KB1, RPS6KB2, SH2B2, SHC1, SHC2, SHC3, SHC4, SKIP, SLC2A4, SOCS1, SOCS2, SOCS3, SOCS4, SORBS1, SOS1, SOS2, SREBF1, TRIP10, TSC1, TSC2 129 ACACA(20), ACACB(23), AKT1(4), AKT2(8), AKT3(3), ARAF(5), CALM1(1), CALM2(1), CALML3(9), CALML6(1), CBL(10), CBLB(21), CBLC(15), CRK(3), CRKL(3), EIF4EBP1(1), ELK1(3), EXOC7(9), FASN(23), FBP1(3), FBP2(2), FLOT1(2), FOXO1(6), G6PC(5), G6PC2(4), GCK(17), GRB2(2), GSK3B(3), GYS1(3), GYS2(24), HRAS(3), IKBKB(4), INPP5D(37), INSR(26), IRS1(5), IRS2(3), IRS4(13), KRAS(5), LIPE(9), MAP2K1(14), MAP2K2(5), MAPK1(4), MAPK10(9), MAPK3(4), MAPK8(1), MAPK9(3), MKNK1(6), MKNK2(3), PCK1(25), PCK2(6), PDE3A(29), PDE3B(6), PDPK1(3), PFKL(4), PFKM(2), PFKP(2), PHKA1(24), PHKA2(9), PHKB(10), PHKG1(1), PHKG2(3), PIK3CA(10), PIK3CB(14), PIK3CD(8), PIK3CG(27), PIK3R1(2), PIK3R2(5), PIK3R3(2), PIK3R5(16), PKLR(13), PKM2(7), PPARGC1A(23), PPP1CA(1), PPP1CB(5), PPP1CC(1), PPP1R3A(62), PPP1R3B(6), PPP1R3C(4), PPP1R3D(3), PRKAA1(1), PRKAA2(30), PRKAB1(2), PRKAB2(2), PRKACA(3), PRKACB(4), PRKACG(11), PRKAG1(3), PRKAG2(8), PRKAG3(10), PRKAR1A(3), PRKAR1B(4), PRKAR2A(1), PRKAR2B(5), PRKCI(8), PRKCZ(7), PRKX(3), PTPN1(4), PTPRF(32), PYGB(3), PYGL(9), PYGM(12), RAF1(10), RAPGEF1(12), RHEB(1), RHOQ(1), RPS6(1), RPS6KB1(3), RPS6KB2(2), SH2B2(4), SHC1(2), SHC2(6), SHC3(14), SHC4(2), SLC2A4(9), SOCS1(1), SOCS2(2), SOCS3(1), SOCS4(3), SORBS1(15), SOS1(10), SOS2(13), SREBF1(5), TRIP10(5), TSC1(9), TSC2(12) 64389982 1029 218 983 478 666 80 40 119 122 2 0.000550 1.000 1.000 76 HSA04610_COMPLEMENT_AND_COAGULATION_CASCADES Genes involved in complement and coagulation cascades A2M, BDKRB1, BDKRB2, C1QA, C1QB, C1QC, C1R, C1S, C2, C3, C3AR1, C4A, C4B, C4BPA, C4BPB, C5, C5AR1, C6, C7, C8A, C8B, C8G, C9, CD46, CD55, CD59, CFB, CFD, CFH, CFI, CPB2, CR1, CR2, F10, F11, F12, F13A1, F13B, F2, F2R, F3, F5, F7, F8, F9, FGA, FGB, FGG, KLKB1, KNG1, MASP1, MASP2, MBL2, PLAT, PLAU, PLAUR, PLG, PROC, PROS1, SERPINA1, SERPINA5, SERPINC1, SERPIND1, SERPINE1, SERPINF2, SERPING1, TFPI, THBD, VWF 66 A2M(31), BDKRB1(6), BDKRB2(9), C1QA(6), C1QB(7), C1QC(10), C1R(16), C1S(20), C3(48), C3AR1(5), C4BPA(16), C4BPB(6), C5(21), C5AR1(10), C6(72), C7(47), C8B(46), C8G(1), C9(22), CD55(6), CD59(1), CFB(55), CFH(80), CFI(18), CPB2(1), CR1(56), CR2(34), F10(7), F11(12), F12(1), F13A1(27), F13B(32), F2(11), F2R(8), F3(2), F5(36), F7(7), F8(49), F9(15), FGA(41), FGB(10), FGG(10), KLKB1(27), KNG1(14), MASP1(10), MASP2(11), MBL2(13), PLAT(4), PLAU(3), PLAUR(3), PLG(34), PROC(12), PROS1(18), SERPINA1(8), SERPINA5(10), SERPINC1(8), SERPIND1(5), SERPINE1(5), SERPINF2(7), SERPING1(13), TFPI(7), THBD(3), VWF(56) 36336612 1189 214 1106 488 832 80 48 114 112 3 3.28e-06 1.000 1.000 77 HSA00230_PURINE_METABOLISM Genes involved in purine metabolism ADA, ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADK, ADSL, ADSS, ADSSL1, AK1, AK2, AK3L1, AK5, AK7, ALLC, AMPD1, AMPD2, AMPD3, APRT, ATIC, CANT1, DCK, DGUOK, ECGF1, ENPP1, ENPP3, ENTPD1, ENTPD2, ENTPD3, ENTPD4, ENTPD5, ENTPD6, ENTPD8, FHIT, GART, GDA, GMPR, GMPR2, GMPS, GUCY1A2, GUCY1A3, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, GUK1, HPRT1, IMPDH1, IMPDH2, ITPA, NME1, NME2, NME4, NME6, NME7, NP, NPR1, NPR2, NT5C, NT5C1A, NT5C1B, NT5C2, NT5C3, NT5E, NT5M, NUDT2, NUDT5, NUDT9, PAICS, PAPSS1, PAPSS2, PDE10A, PDE11A, PDE1A, PDE1C, PDE2A, PDE3B, PDE4A, PDE4B, PDE4C, PDE4D, PDE5A, PDE6D, PDE6G, PDE6H, PDE7A, PDE7B, PDE8A, PDE8B, PDE9A, PFAS, PKLR, PKM2, PNPT1, POLA1, POLA2, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, POLE3, POLE4, POLR1A, POLR1B, POLR1C, POLR1D, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLR3A, POLR3B, POLR3G, POLR3GL, POLR3H, POLR3K, PPAT, PRIM1, PRIM2, PRPS1, PRPS1L1, PRPS2, PRUNE, RFC5, RRM1, RRM2, RRM2B, SAC, XDH, ZNRD1 140 ADA(2), ADCY1(34), ADCY2(10), ADCY3(3), ADCY4(5), ADCY5(19), ADCY6(9), ADCY7(11), ADCY8(55), ADCY9(10), ADK(4), ADSL(5), ADSS(1), ADSSL1(7), AK1(1), AK2(3), AK5(10), AK7(26), ALLC(6), AMPD1(34), AMPD2(7), AMPD3(25), APRT(3), ATIC(5), CANT1(10), DGUOK(4), ENPP1(13), ENPP3(13), ENTPD1(12), ENTPD2(4), ENTPD3(9), ENTPD4(4), ENTPD5(2), ENTPD6(4), ENTPD8(2), FHIT(2), GART(11), GDA(16), GMPR(2), GMPR2(1), GMPS(6), GUCY1A2(21), GUCY1A3(32), GUCY1B3(7), GUCY2C(38), GUCY2D(9), GUCY2F(23), GUK1(3), IMPDH1(4), IMPDH2(1), ITPA(1), NME4(1), NME6(3), NME7(4), NPR1(18), NPR2(20), NT5C1A(6), NT5C2(3), NT5C3(2), NT5E(6), NT5M(2), NUDT2(1), NUDT5(1), NUDT9(2), PAICS(1), PAPSS1(4), PAPSS2(5), PDE10A(12), PDE11A(20), PDE1C(52), PDE2A(16), PDE3B(6), PDE4A(11), PDE4B(8), PDE4C(19), PDE4D(7), PDE5A(10), PDE6D(2), PDE6G(2), PDE7A(1), PDE7B(16), PDE8A(3), PDE8B(22), PDE9A(11), PFAS(12), PKLR(13), PKM2(7), PNPT1(3), POLA1(3), POLA2(8), POLD1(7), POLD2(2), POLD3(7), POLE(16), POLE2(2), POLR1A(13), POLR1B(9), POLR1C(1), POLR2A(13), POLR2B(12), POLR2C(1), POLR2D(1), POLR2E(3), POLR2F(1), POLR2H(2), POLR2J(1), POLR3A(7), POLR3B(14), POLR3G(1), POLR3GL(2), POLR3H(1), POLR3K(1), PRIM1(2), PRPS1(2), PRPS1L1(13), PRPS2(2), PRUNE(3), RRM1(3), RRM2(3), RRM2B(2), XDH(59) 65744276 1098 213 1049 555 750 91 52 96 109 0 0.000720 1.000 1.000 78 HSA04640_HEMATOPOIETIC_CELL_LINEAGE Genes involved in hematopoietic cell lineage ANPEP, CD14, CD19, CD1A, CD1B, CD1C, CD1D, CD1E, CD2, CD22, CD24, CD33, CD34, CD36, CD37, CD38, CD3D, CD3E, CD3G, CD4, CD44, CD5, CD55, CD59, CD7, CD8A, CD8B, CD9, CR1, CR2, CSF1, CSF1R, CSF2, CSF2RA, CSF3, CSF3R, DNTT, EPO, EPOR, FCER2, FCGR1A, FLT3, FLT3LG, GP1BA, GP1BB, GP5, GP9, GYPA, HLA-DRA, HLA-DRB1, HLA-DRB3, HLA-DRB4, HLA-DRB5, IL11, IL11RA, IL1A, IL1B, IL1R1, IL1R2, IL2RA, IL3, IL3RA, IL4, IL4R, IL5, IL5RA, IL6, IL6R, IL7, IL7R, IL9R, ITGA1, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGAM, ITGB3, KIT, KITLG, MME, MS4A1, TFRC, THPO, TNF, TPO 83 ANPEP(24), CD14(5), CD19(8), CD1A(14), CD1B(13), CD1C(27), CD1D(10), CD1E(26), CD2(27), CD22(23), CD33(21), CD34(4), CD36(6), CD37(3), CD38(6), CD3D(7), CD3E(2), CD3G(1), CD4(8), CD44(5), CD5(7), CD55(6), CD59(1), CD7(1), CD8A(2), CD8B(7), CD9(2), CR1(56), CR2(34), CSF1(12), CSF1R(13), CSF2(2), CSF2RA(20), CSF3(4), CSF3R(9), DNTT(10), EPO(5), EPOR(1), FCER2(2), FCGR1A(9), FLT3(35), FLT3LG(1), GP5(7), GP9(6), GYPA(16), HLA-DRA(12), HLA-DRB5(6), IL11(3), IL11RA(3), IL1A(5), IL1B(8), IL1R1(13), IL1R2(8), IL2RA(5), IL3(3), IL3RA(7), IL4(1), IL4R(16), IL5(4), IL5RA(17), IL6(2), IL6R(3), IL7(4), IL7R(34), IL9R(6), ITGA1(24), ITGA2(13), ITGA2B(12), ITGA3(8), ITGA4(43), ITGA5(25), ITGA6(10), ITGAM(23), ITGB3(15), KIT(12), KITLG(11), MME(23), MS4A1(7), TFRC(4), THPO(9), TNF(1), TPO(47) 33149315 955 210 889 446 669 51 33 74 126 2 0.000652 1.000 1.000 79 HSA04730_LONG_TERM_DEPRESSION Genes involved in long-term depression ARAF, BRAF, C7orf16, CACNA1A, CRH, CRHR1, GNA11, GNA12, GNA13, GNAI1, GNAI2, GNAI3, GNAO1, GNAQ, GNAS, GNAZ, GRIA1, GRIA2, GRIA3, GRID2, GRM1, GRM5, GUCY1A2, GUCY1A3, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, HRAS, IGF1, IGF1R, ITPR1, ITPR2, ITPR3, KRAS, LYN, MAP2K1, MAP2K2, MAPK1, MAPK3, NOS1, NOS2A, NOS3, NPR1, NPR2, NRAS, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCB1, PLCB2, PLCB3, PLCB4, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, PRKCA, PRKCB1, PRKCG, PRKG1, PRKG2, RAF1, RYR1 72 ARAF(5), CACNA1A(38), CRH(3), CRHR1(7), GNA11(8), GNA12(3), GNA13(1), GNAI1(2), GNAI2(6), GNAI3(2), GNAO1(2), GNAQ(6), GNAS(25), GNAZ(7), GRIA1(45), GRIA2(41), GRIA3(24), GRID2(59), GRM1(16), GRM5(15), GUCY1A2(21), GUCY1A3(32), GUCY1B3(7), GUCY2C(38), GUCY2D(9), GUCY2F(23), HRAS(3), IGF1(10), IGF1R(14), ITPR1(36), ITPR2(20), ITPR3(11), KRAS(5), LYN(10), MAP2K1(14), MAP2K2(5), MAPK1(4), MAPK3(4), NOS1(74), NOS3(19), NPR1(18), NPR2(20), PLA2G12B(4), PLA2G1B(1), PLA2G2A(2), PLA2G2D(5), PLA2G2E(5), PLA2G2F(6), PLA2G3(17), PLA2G4A(15), PLA2G5(2), PLA2G6(12), PLCB1(54), PLCB2(12), PLCB3(4), PLCB4(86), PPP2CB(2), PPP2R1A(4), PPP2R1B(3), PPP2R2B(6), PPP2R2C(8), PRKCA(8), PRKCG(16), PRKG1(14), PRKG2(16), RAF1(10), RYR1(109) 43807900 1133 210 1038 606 790 71 35 100 133 4 0.000209 1.000 1.000 80 HSA00500_STARCH_AND_SUCROSE_METABOLISM Genes involved in starch and sucrose metabolism AGL, AMY1A, AMY1B, AMY1C, AMY2A, AMY2B, ASCC3, ASCC3L1, ATP13A2, DDX18, DDX19A, DDX23, DDX4, DDX41, DDX47, DDX50, DDX51, DDX52, DDX54, DDX55, DDX56, DHX58, ENPP1, ENPP3, ENTPD7, EP400, ERCC2, ERCC3, G6PC, G6PC2, GAA, GANC, GBA, GBA3, GBE1, GCK, GPI, GUSB, GYS1, GYS2, HK1, HK2, HK3, IFIH1, LYZL1, MGAM, MOV10L1, NUDT5, NUDT8, PGM1, PGM3, PYGB, PYGL, PYGM, RAD54B, RAD54L, RUVBL2, SETX, SI, SKIV2L2, SMARCA2, SMARCA5, TREH, UGDH, UGP2, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, UXS1 79 AGL(18), AMY2A(6), AMY2B(13), ASCC3(13), ATP13A2(12), DDX18(5), DDX23(6), DDX4(12), DDX41(7), DDX47(1), DDX50(4), DDX51(5), DDX52(4), DDX54(3), DDX55(2), DDX56(3), DHX58(4), ENPP1(13), ENPP3(13), ENTPD7(2), EP400(27), ERCC2(3), ERCC3(6), G6PC(5), G6PC2(4), GAA(8), GANC(7), GBA(7), GBA3(19), GBE1(9), GCK(17), GPI(3), GUSB(5), GYS1(3), GYS2(24), HK1(3), HK2(13), HK3(14), IFIH1(12), MGAM(162), MOV10L1(25), NUDT5(1), NUDT8(2), PGM1(6), PGM3(1), PYGB(3), PYGL(9), PYGM(12), RAD54B(8), RUVBL2(5), SETX(19), SI(87), SKIV2L2(6), SMARCA2(14), SMARCA5(5), TREH(4), UGDH(1), UGP2(1), UGT1A1(77), UGT2A3(28), UGT2B10(45), UGT2B11(23), UGT2B15(31), UGT2B17(29), UGT2B28(26), UGT2B4(34), UGT2B7(19), UXS1(4) 49668621 1022 209 941 428 707 80 36 76 122 1 1.25e-06 1.000 1.000 81 HSA04720_LONG_TERM_POTENTIATION Genes involved in long-term potentiation ADCY1, ADCY8, ARAF, ATF4, BRAF, CACNA1C, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CHP, CREBBP, EP300, GNAQ, GRIA1, GRIA2, GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D, GRM1, GRM5, HRAS, ITPR1, ITPR2, ITPR3, KRAS, MAP2K1, MAP2K2, MAPK1, MAPK3, NRAS, PLCB1, PLCB2, PLCB3, PLCB4, PPP1CA, PPP1CB, PPP1CC, PPP1R12A, PPP1R1A, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, RAF1, RAP1A, RAP1B, RAPGEF3, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA6 65 ADCY1(34), ADCY8(55), ARAF(5), ATF4(9), CACNA1C(62), CALM1(1), CALM2(1), CALML3(9), CALML6(1), CAMK2A(6), CAMK2B(6), CAMK2D(6), CAMK2G(5), CAMK4(17), CREBBP(24), EP300(18), GNAQ(6), GRIA1(45), GRIA2(41), GRIN1(8), GRIN2A(105), GRIN2B(57), GRIN2C(8), GRIN2D(10), GRM1(16), GRM5(15), HRAS(3), ITPR1(36), ITPR2(20), ITPR3(11), KRAS(5), MAP2K1(14), MAP2K2(5), MAPK1(4), MAPK3(4), PLCB1(54), PLCB2(12), PLCB3(4), PLCB4(86), PPP1CA(1), PPP1CB(5), PPP1CC(1), PPP1R12A(4), PPP1R1A(5), PPP3CA(5), PPP3CB(3), PPP3CC(2), PPP3R2(5), PRKACA(3), PRKACB(4), PRKACG(11), PRKCA(8), PRKCG(16), PRKX(3), RAF1(10), RAP1A(2), RAP1B(1), RAPGEF3(14), RPS6KA1(8), RPS6KA2(6), RPS6KA3(1), RPS6KA6(19) 39340456 965 208 893 545 650 78 39 94 100 4 0.0482 1.000 1.000 82 HSA04670_LEUKOCYTE_TRANSENDOTHELIAL_MIGRATION Genes involved in Leukocyte transendothelial migration ACTN1, ACTN2, ACTN3, ACTN4, ARHGAP5, BCAR1, CD99, CDC42, CDH5, CLDN1, CLDN10, CLDN11, CLDN14, CLDN15, CLDN16, CLDN17, CLDN18, CLDN19, CLDN2, CLDN20, CLDN22, CLDN23, CLDN3, CLDN4, CLDN5, CLDN6, CLDN7, CLDN8, CLDN9, CTNNA1, CTNNA2, CTNNA3, CTNNB1, CTNND1, CXCL12, CXCR4, CYBA, CYBB, ESAM, EZR, F11R, GNAI1, GNAI2, GNAI3, GRLF1, ICAM1, ITGA4, ITGAL, ITGAM, ITGB1, ITGB2, ITK, JAM2, JAM3, MAPK11, MAPK12, MAPK13, MAPK14, MLLT4, MMP2, MMP9, MRCL3, MRLC2, MSN, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLPF, NCF1, NCF2, NCF4, NOX1, NOX3, OCLN, PECAM1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PLCG2, PRKCA, PRKCB1, PRKCG, PTK2, PTK2B, PTPN11, PXN, RAC1, RAC2, RAP1A, RAP1B, RAPGEF3, RAPGEF4, RASSF5, RHOA, RHOH, ROCK1, ROCK2, SIPA1, THY1, TXK, VASP, VAV1, VAV2, VAV3, VCAM1, VCL 109 ACTN1(8), ACTN2(20), ACTN3(3), ACTN4(5), ARHGAP5(13), BCAR1(5), CD99(1), CDC42(2), CDH5(11), CLDN1(5), CLDN10(7), CLDN11(5), CLDN14(5), CLDN15(1), CLDN16(7), CLDN17(5), CLDN18(8), CLDN19(2), CLDN2(6), CLDN20(1), CLDN22(1), CLDN3(2), CLDN4(11), CLDN6(8), CLDN7(1), CLDN8(4), CLDN9(1), CTNNA1(3), CTNNA2(30), CTNNA3(38), CTNNB1(14), CTNND1(8), CXCL12(3), CXCR4(3), CYBA(1), CYBB(8), ESAM(5), EZR(5), F11R(7), GNAI1(2), GNAI2(6), GNAI3(2), ICAM1(2), ITGA4(43), ITGAL(28), ITGAM(23), ITGB1(4), ITGB2(16), ITK(24), JAM2(11), JAM3(3), MAPK11(1), MAPK12(1), MAPK13(5), MAPK14(5), MLLT4(16), MMP2(8), MMP9(7), MSN(2), MYL2(9), MYL5(1), MYL7(3), MYL9(2), MYLPF(2), NCF1(3), NCF2(9), NCF4(5), NOX1(13), NOX3(7), OCLN(7), PIK3CA(10), PIK3CB(14), PIK3CD(8), PIK3CG(27), PIK3R1(2), PIK3R2(5), PIK3R3(2), PIK3R5(16), PLCG1(8), PLCG2(27), PRKCA(8), PRKCG(16), PTK2(7), PTK2B(10), PTPN11(10), PXN(2), RAC2(3), RAP1A(2), RAP1B(1), RAPGEF3(14), RAPGEF4(17), RASSF5(4), RHOA(2), RHOH(6), ROCK1(7), ROCK2(11), SIPA1(8), THY1(1), TXK(10), VASP(3), VAV1(19), VAV2(3), VAV3(14), VCAM1(17), VCL(8) 50209449 865 207 820 427 562 64 28 94 114 3 0.000928 1.000 1.000 83 HSA02010_ABC_TRANSPORTERS_GENERAL Genes involved in ABC transporters - general ABCA1, ABCA10, ABCA12, ABCA13, ABCA2, ABCA3, ABCA4, ABCA5, ABCA6, ABCA7, ABCA8, ABCA9, ABCB1, ABCB10, ABCB11, ABCB4, ABCB5, ABCB6, ABCB7, ABCB8, ABCB9, ABCC1, ABCC10, ABCC11, ABCC12, ABCC2, ABCC3, ABCC4, ABCC5, ABCC6, ABCC8, ABCC9, ABCD1, ABCD2, ABCD3, ABCD4, ABCG1, ABCG2, ABCG4, ABCG5, ABCG8, CFTR, TAP1, TAP2 44 ABCA1(15), ABCA10(23), ABCA12(78), ABCA13(76), ABCA2(15), ABCA3(17), ABCA4(56), ABCA5(12), ABCA6(28), ABCA7(18), ABCA8(37), ABCA9(23), ABCB1(39), ABCB10(7), ABCB11(49), ABCB4(21), ABCB5(51), ABCB6(2), ABCB7(5), ABCB8(3), ABCB9(6), ABCC1(15), ABCC10(16), ABCC11(19), ABCC12(25), ABCC2(11), ABCC3(29), ABCC4(14), ABCC5(11), ABCC6(30), ABCC8(44), ABCC9(59), ABCD2(17), ABCD3(9), ABCD4(3), ABCG1(12), ABCG2(6), ABCG4(7), ABCG5(5), ABCG8(15), CFTR(60), TAP1(2), TAP2(14) 47982619 1004 206 944 560 661 76 34 108 123 2 0.00173 1.000 1.000 84 HSA04070_PHOSPHATIDYLINOSITOL_SIGNALING_SYSTEM Genes involved in phosphatidylinositol signaling system CALM1, CALM2, CALM3, CALML3, CALML6, CARKL, CDIPT, CDS1, CDS2, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKI, DGKQ, DGKZ, FN3K, IMPA1, IMPA2, INPP1, INPP4A, INPP4B, INPP5A, INPP5B, INPP5D, INPP5E, INPPL1, ITGB1BP3, ITPK1, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, OCRL, PI4KA, PI4KB, PIB5PA, PIK3C2A, PIK3C2B, PIK3C2G, PIK3C3, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIP4K2A, PIP4K2B, PIP4K2C, PIP5K1A, PIP5K1B, PIP5K1C, PIP5K3, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCD3, PLCD4, PLCE1, PLCG1, PLCG2, PLCZ1, PRKCA, PRKCB1, PRKCG, PTEN, PTPMT1, SKIP, SYNJ1, SYNJ2 72 CALM1(1), CALM2(1), CALML3(9), CALML6(1), CDS1(11), CDS2(5), DGKA(3), DGKB(27), DGKD(14), DGKE(8), DGKG(18), DGKH(10), DGKI(31), DGKQ(7), DGKZ(6), IMPA1(1), IMPA2(4), INPP1(3), INPP4A(7), INPP4B(2), INPP5A(4), INPP5B(6), INPP5D(37), INPPL1(16), ITGB1BP3(1), ITPK1(5), ITPKB(11), ITPR1(36), ITPR2(20), ITPR3(11), OCRL(6), PI4KA(21), PI4KB(8), PIK3C2A(8), PIK3C2B(16), PIK3C2G(53), PIK3C3(3), PIK3CA(10), PIK3CB(14), PIK3CD(8), PIK3CG(27), PIK3R1(2), PIK3R2(5), PIK3R3(2), PIK3R5(16), PIP4K2A(6), PIP4K2B(3), PIP4K2C(2), PIP5K1A(6), PIP5K1B(21), PIP5K1C(9), PLCB1(54), PLCB2(12), PLCB3(4), PLCB4(86), PLCD1(4), PLCD3(4), PLCD4(4), PLCE1(57), PLCG1(8), PLCG2(27), PLCZ1(30), PRKCA(8), PRKCG(16), SYNJ1(20), SYNJ2(22) 50118877 918 205 846 425 638 46 38 80 113 3 1.09e-05 1.000 1.000 85 INTEGRIN_MEDIATED_CELL_ADHESION_KEGG AKT1, AKT3, BCAR1, CAPN1, CAPN10, CAPN11, CAPN2, CAPN3, CAPN5, CAPN6, CAPN7, CAPN9, CAPNS1, CAV1, CAV2, CAV3, CDC42, CRK, CSK, DKFZp434E1119, DOCK1, FLJ14825, FLJ40125, FYN, GIT2, GRB2, ILK, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAD, ITGAE, ITGAL, ITGAM, ITGAV, ITGAX, ITGB1, ITGB2, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, LOC283874, PDPK1, MAP2K1, MAP2K2, MAP2K3, MAP2K6, MAPK10, MAPK12, MAPK4, MAPK6, MAPK7, MGC17301, MYLK2, PAK1, PAK2, PAK3, PAK4, PAK6, PDPK1, PIK3R2, PTK2, PXN, RAC1, RAC2, RAC3, RAP1B, RAPGEF1, RHO, ROCK1, ROCK2, SDCCAG8, SEPP1, SHC1, SHC3, SORBS1, SOS1, SRC, TLN1, TNS, TNS1, VASP, VAV2, VAV3, VCL, ZYX 89 AKT1(4), AKT3(3), BCAR1(5), CAPN1(4), CAPN10(7), CAPN11(10), CAPN2(5), CAPN3(9), CAPN5(4), CAPN6(16), CAPN7(1), CAPN9(12), CAPNS1(3), CAV1(1), CAV3(2), CDC42(2), CRK(3), CSK(1), DOCK1(17), FYN(7), GIT2(8), GRB2(2), ILK(2), ITGA10(12), ITGA11(19), ITGA2(13), ITGA2B(12), ITGA3(8), ITGA4(43), ITGA5(25), ITGA6(10), ITGA7(25), ITGA8(37), ITGA9(13), ITGAD(30), ITGAE(21), ITGAL(28), ITGAM(23), ITGAV(9), ITGAX(23), ITGB1(4), ITGB2(16), ITGB3(15), ITGB4(22), ITGB5(9), ITGB6(11), ITGB7(6), ITGB8(20), MAP2K1(14), MAP2K2(5), MAP2K3(8), MAP2K6(3), MAPK10(9), MAPK12(1), MAPK4(18), MAPK6(7), MAPK7(4), MYLK2(12), PAK1(4), PAK2(7), PAK3(10), PAK4(8), PAK6(6), PDPK1(3), PIK3R2(5), PTK2(7), PXN(2), RAC2(3), RAP1B(1), RAPGEF1(12), RHO(2), ROCK1(7), ROCK2(11), SDCCAG8(3), SEPP1(11), SHC1(2), SHC3(14), SORBS1(15), SOS1(10), SRC(2), TLN1(12), TNS1(8), VASP(3), VAV2(3), VAV3(14), VCL(8), ZYX(8) 53958865 864 205 829 421 568 64 32 102 96 2 0.00504 1.000 1.000 86 HSA04650_NATURAL_KILLER_CELL_MEDIATED_CYTOTOXICITY Genes involved in natural killer cell mediated cytotoxicity ARAF, BID, BRAF, CASP3, CD244, CD247, CD48, CHP, CSF2, FAS, FASLG, FCER1G, FCGR3A, FCGR3B, FYN, GRB2, GZMB, HCST, HLA-A, HLA-B, HLA-C, HLA-E, HLA-G, HRAS, ICAM1, ICAM2, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IFNG, IFNGR1, IFNGR2, ITGAL, ITGB2, KIR2DL1, KIR2DL2, KIR2DL3, KIR2DL4, KIR2DL5A, KIR2DS1, KIR2DS2, KIR3DL1, KIR3DL2, KLRC1, KLRC2, KLRC3, KLRD1, KLRK1, KRAS, LAT, LCK, LCP2, LOC652578, MAP2K1, MAP2K2, MAPK1, MAPK3, MICA, MICB, NCR1, NCR2, NCR3, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NRAS, PAK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PLCG2, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRF1, PRKCA, PRKCB1, PRKCG, PTK2B, PTPN11, PTPN6, RAC1, RAC2, RAC3, RAF1, SH2D1A, SH2D1B, SH3BP2, SHC1, SHC2, SHC3, SHC4, SOS1, SOS2, SYK, TNF, TNFRSF10A, TNFRSF10B, TNFRSF10C, TNFRSF10D, TNFSF10, TYROBP, ULBP1, ULBP2, ULBP3, VAV1, VAV2, VAV3, ZAP70 123 ARAF(5), CASP3(2), CD244(10), CD247(4), CD48(6), CSF2(2), FAS(6), FASLG(15), FCER1G(1), FCGR3A(7), FCGR3B(9), FYN(7), GRB2(2), GZMB(3), HLA-A(3), HLA-C(9), HLA-E(1), HLA-G(6), HRAS(3), ICAM1(2), ICAM2(4), IFNA1(1), IFNA10(2), IFNA13(1), IFNA14(8), IFNA16(11), IFNA17(2), IFNA2(1), IFNA21(7), IFNA4(1), IFNA5(4), IFNA6(2), IFNA7(6), IFNA8(3), IFNAR1(2), IFNAR2(14), IFNB1(6), IFNG(4), IFNGR1(3), IFNGR2(4), ITGAL(28), ITGB2(16), KIR2DL1(29), KIR3DL2(45), KLRC1(4), KLRC2(14), KLRD1(5), KLRK1(8), KRAS(5), LAT(2), LCK(15), LCP2(9), MAP2K1(14), MAP2K2(5), MAPK1(4), MAPK3(4), MICA(4), MICB(7), NCR1(17), NCR2(13), NCR3(4), NFAT5(8), NFATC1(16), NFATC2(11), NFATC3(10), NFATC4(17), PAK1(4), PIK3CA(10), PIK3CB(14), PIK3CD(8), PIK3CG(27), PIK3R1(2), PIK3R2(5), PIK3R3(2), PIK3R5(16), PLCG1(8), PLCG2(27), PPP3CA(5), PPP3CB(3), PPP3CC(2), PPP3R2(5), PRF1(11), PRKCA(8), PRKCG(16), PTK2B(10), PTPN11(10), PTPN6(5), RAC2(3), RAF1(10), SH2D1A(3), SH2D1B(4), SH3BP2(2), SHC1(2), SHC2(6), SHC3(14), SHC4(2), SOS1(10), SOS2(13), SYK(14), TNF(1), TNFRSF10A(7), TNFRSF10B(4), TNFRSF10C(4), TNFRSF10D(9), TNFSF10(8), TYROBP(4), ULBP1(2), ULBP2(1), ULBP3(5), VAV1(19), VAV2(3), VAV3(14), ZAP70(7) 45085678 872 203 829 415 565 62 32 94 118 1 0.00513 1.000 1.000 87 HSA00980_METABOLISM_OF_XENOBIOTICS_BY_CYTOCHROME_P450 Genes involved in metabolism of xenobiotics by cytochrome P450 ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AKR1C1, AKR1C2, AKR1C3, AKR1C4, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, CYP1A1, CYP1A2, CYP1B1, CYP2B6, CYP2C18, CYP2C19, CYP2C8, CYP2C9, CYP2E1, CYP2F1, CYP2S1, CYP3A4, CYP3A43, CYP3A5, CYP3A7, DHDH, EPHX1, GSTA1, GSTA2, GSTA3, GSTA4, GSTA5, GSTK1, GSTM1, GSTM2, GSTM3, GSTM4, GSTM5, GSTO2, GSTP1, GSTT1, GSTT2, GSTZ1, MGST1, MGST2, MGST3, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7 68 ADH1A(17), ADH1B(30), ADH1C(1), ADH4(10), ADH5(3), ADH6(14), ADH7(16), ADHFE1(6), AKR1C2(3), AKR1C3(14), AKR1C4(10), ALDH1A3(2), ALDH3A1(8), ALDH3B1(3), ALDH3B2(8), CYP1A1(9), CYP1A2(8), CYP1B1(4), CYP2B6(21), CYP2C19(75), CYP2C8(32), CYP2C9(38), CYP2E1(13), CYP2F1(12), CYP2S1(14), CYP3A4(20), CYP3A43(19), CYP3A7(30), DHDH(5), EPHX1(2), GSTA1(6), GSTA2(3), GSTA3(1), GSTA4(1), GSTA5(3), GSTK1(3), GSTM1(2), GSTM3(4), GSTM4(2), GSTM5(6), GSTO2(1), GSTP1(3), GSTT1(1), GSTZ1(1), MGST1(2), MGST2(2), MGST3(1), UGT1A1(77), UGT2A3(28), UGT2B10(45), UGT2B11(23), UGT2B15(31), UGT2B17(29), UGT2B28(26), UGT2B4(34), UGT2B7(19) 22915878 801 202 724 328 577 49 31 47 95 2 1.45e-11 1.000 1.000 88 HSA04912_GNRH_SIGNALING_PATHWAY Genes involved in GnRH signaling pathway ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ATF4, CACNA1C, CACNA1D, CACNA1F, CACNA1S, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CDC42, CGA, EGFR, ELK1, FSHB, GNA11, GNAQ, GNAS, GNRH1, GNRH2, GNRHR, GRB2, HBEGF, HRAS, ITPR1, ITPR2, ITPR3, JUN, KRAS, LHB, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAP3K1, MAP3K2, MAP3K3, MAP3K4, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK7, MAPK8, MAPK9, MMP14, MMP2, NRAS, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCB1, PLCB2, PLCB3, PLCB4, PLD1, PLD2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCD, PRKX, PRKY, PTK2B, RAF1, SOS1, SOS2, SRC 94 ADCY1(34), ADCY2(10), ADCY3(3), ADCY4(5), ADCY5(19), ADCY6(9), ADCY7(11), ADCY8(55), ADCY9(10), ATF4(9), CACNA1C(62), CACNA1D(33), CACNA1F(23), CACNA1S(53), CALM1(1), CALM2(1), CALML3(9), CALML6(1), CAMK2A(6), CAMK2B(6), CAMK2D(6), CAMK2G(5), CDC42(2), CGA(1), EGFR(25), ELK1(3), FSHB(8), GNA11(8), GNAQ(6), GNAS(25), GNRH2(2), GNRHR(2), GRB2(2), HBEGF(1), HRAS(3), ITPR1(36), ITPR2(20), ITPR3(11), JUN(1), KRAS(5), MAP2K1(14), MAP2K2(5), MAP2K3(8), MAP2K4(4), MAP2K6(3), MAP2K7(5), MAP3K1(4), MAP3K2(6), MAP3K3(8), MAP3K4(17), MAPK1(4), MAPK10(9), MAPK11(1), MAPK12(1), MAPK13(5), MAPK14(5), MAPK3(4), MAPK7(4), MAPK8(1), MAPK9(3), MMP14(3), MMP2(8), PLA2G12B(4), PLA2G1B(1), PLA2G2A(2), PLA2G2D(5), PLA2G2E(5), PLA2G2F(6), PLA2G3(17), PLA2G4A(15), PLA2G5(2), PLA2G6(12), PLCB1(54), PLCB2(12), PLCB3(4), PLCB4(86), PLD1(13), PLD2(8), PRKACA(3), PRKACB(4), PRKACG(11), PRKCA(8), PRKCD(5), PRKX(3), PTK2B(10), RAF1(10), SOS1(10), SOS2(13), SRC(2) 51211704 979 202 919 586 630 89 46 95 115 4 0.141 1.000 1.000 89 HSA01030_GLYCAN_STRUCTURES_BIOSYNTHESIS_1 Genes involved in glycan structures - biosynthesis 1 A4GNT, ALG1, ALG10, ALG10B, ALG11, ALG12, ALG13, ALG14, ALG2, ALG3, ALG6, ALG8, ALG9, B3GALT6, B3GNT1, B3GNT2, B3GNT6, B3GNT7, B4GALT1, B4GALT2, B4GALT3, B4GALT4, B4GALT5, B4GALT7, C1GALT1, C1GALT1C1, ChGn, CHPF, CHST1, CHST11, CHST12, CHST13, CHST14, CHST2, CHST3, CHST4, CHST6, CHST7, CHSY-2, CHSY1, CSGlcA-T, DAD1, DDOST, DPAGT1, EXT1, EXT2, EXTL1, EXTL2, EXTL3, FUT11, FUT8, GALNAC4S-6ST, GALNACT-2, GALNT1, GALNT10, GALNT11, GALNT12, GALNT13, GALNT14, GALNT17, GALNT2, GALNT3, GALNT4, GALNT5, GALNT6, GALNT7, GALNT8, GALNT9, GALNTL1, GALNTL2, GALNTL4, GALNTL5, GANAB, GCNT1, GCNT3, GCNT4, GCS1, HS2ST1, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, HS3ST5, HS6ST1, HS6ST2, HS6ST3, LOC728969, MAN1A1, MAN1A2, MAN1B1, MAN1C1, MAN2A1, MGAT1, MGAT2, MGAT3, MGAT4A, MGAT4B, MGAT5, MGAT5B, NDST1, NDST2, NDST3, NDST4, OGT, RPN1, RPN2, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4, ST6GAL1, ST6GALNAC1, STT3B, UST, WBSCR17, XYLT1, XYLT2 108 A4GNT(9), ALG1(3), ALG10(6), ALG10B(4), ALG12(1), ALG13(10), ALG14(2), ALG2(5), ALG3(4), ALG6(2), ALG8(7), ALG9(6), B3GNT1(3), B3GNT2(2), B3GNT6(1), B3GNT7(6), B4GALT1(2), B4GALT2(2), B4GALT3(2), B4GALT4(3), B4GALT5(2), C1GALT1(6), C1GALT1C1(3), CHPF(4), CHST1(10), CHST11(7), CHST12(5), CHST13(3), CHST14(3), CHST2(5), CHST3(2), CHST4(10), CHST6(4), CHST7(3), CHSY1(8), DAD1(1), DDOST(2), DPAGT1(2), EXT1(2), EXT2(8), EXTL1(2), EXTL3(12), FUT11(4), FUT8(8), GALNT1(4), GALNT10(7), GALNT11(2), GALNT12(8), GALNT13(29), GALNT14(24), GALNT2(6), GALNT3(4), GALNT4(5), GALNT5(13), GALNT6(17), GALNT7(4), GALNT8(27), GALNT9(7), GALNTL1(6), GALNTL2(22), GALNTL4(10), GALNTL5(18), GANAB(5), GCNT1(6), GCNT3(7), GCNT4(4), HS2ST1(1), HS3ST1(10), HS3ST2(9), HS3ST3A1(6), HS3ST3B1(2), HS3ST5(8), HS6ST1(2), HS6ST2(3), HS6ST3(15), MAN1A1(18), MAN1A2(7), MAN1B1(3), MAN1C1(11), MAN2A1(10), MGAT1(3), MGAT2(2), MGAT3(11), MGAT4A(8), MGAT4B(1), MGAT5(6), MGAT5B(12), NDST1(6), NDST2(2), NDST3(25), NDST4(52), OGT(10), RPN2(4), ST3GAL1(7), ST3GAL2(1), ST3GAL3(2), ST3GAL4(2), ST6GAL1(6), ST6GALNAC1(8), STT3B(5), WBSCR17(44), XYLT1(12), XYLT2(4) 44693656 769 201 735 399 498 60 31 85 95 0 0.0207 1.000 1.000 90 HSA04110_CELL_CYCLE Genes involved in cell cycle ABL1, ANAPC1, ANAPC10, ANAPC11, ANAPC2, ANAPC4, ANAPC5, ANAPC7, ATM, ATR, BUB1, BUB1B, BUB3, CCNA1, CCNA2, CCNB1, CCNB2, CCNB3, CCND1, CCND2, CCND3, CCNE1, CCNE2, CCNH, CDC14A, CDC14B, CDC16, CDC2, CDC20, CDC23, CDC25A, CDC25B, CDC25C, CDC26, CDC27, CDC45L, CDC6, CDC7, CDK2, CDK4, CDK6, CDK7, CDKN1A, CDKN1B, CDKN1C, CDKN2A, CDKN2B, CDKN2C, CDKN2D, CHEK1, CHEK2, CREBBP, CUL1, DBF4, E2F1, E2F2, E2F3, EP300, ESPL1, FZR1, GADD45A, GADD45B, GADD45G, GSK3B, hCG_1982709, HDAC1, HDAC2, LOC440917, LOC728919, MAD1L1, MAD2L1, MAD2L2, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, MDM2, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, PKMYT1, PLK1, PRKDC, PTTG1, PTTG2, RB1, RBL1, RBL2, RBX1, SFN, SKP1, SKP2, SMAD2, SMAD3, SMAD4, SMC1A, SMC1B, TFDP1, TGFB1, TGFB2, TGFB3, TP53, WEE1, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ 108 ABL1(13), ANAPC1(17), ANAPC10(1), ANAPC2(6), ANAPC4(6), ANAPC5(10), ANAPC7(6), ATM(15), ATR(23), BUB1(6), BUB1B(10), BUB3(1), CCNA1(14), CCNB2(2), CCNB3(31), CCND1(2), CCND2(6), CCND3(2), CCNE1(4), CCNE2(8), CCNH(2), CDC14A(6), CDC14B(3), CDC16(1), CDC20(1), CDC23(4), CDC25A(8), CDC25B(4), CDC25C(5), CDC27(13), CDC6(2), CDC7(2), CDK4(7), CDK6(2), CDK7(2), CDKN1A(3), CDKN1B(1), CDKN2C(1), CHEK1(2), CHEK2(2), CREBBP(24), CUL1(5), DBF4(6), E2F1(5), E2F2(5), E2F3(5), EP300(18), ESPL1(20), FZR1(7), GADD45B(2), GSK3B(3), HDAC1(2), HDAC2(2), MAD1L1(6), MAD2L1(1), MAD2L2(1), MCM2(11), MCM3(9), MCM4(8), MCM5(5), MCM6(5), MCM7(1), MDM2(1), PCNA(2), PKMYT1(3), PLK1(4), PRKDC(19), PTTG1(1), PTTG2(4), RB1(10), RBL1(12), RBL2(6), SKP2(2), SMAD2(3), SMAD3(4), SMAD4(1), SMC1A(3), SMC1B(23), TFDP1(2), TGFB1(2), TGFB2(3), TGFB3(3), WEE1(2), YWHAB(1), YWHAE(2), YWHAG(2), YWHAQ(3) 55020777 523 198 510 211 298 46 35 83 59 2 0.00930 1.000 1.000 91 HSA04620_TOLL_LIKE_RECEPTOR_SIGNALING_PATHWAY Genes involved in Toll-like receptor signaling pathway AKT1, AKT2, AKT3, CASP8, CCL3, CCL4, CCL5, CD14, CD40, CD80, CD86, CHUK, CXCL10, CXCL11, CXCL9, FADD, FOS, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IKBKB, IKBKE, IKBKG, IL12A, IL12B, IL1B, IL6, IL8, IRAK1, IRAK4, IRF3, IRF5, IRF7, JUN, LBP, LY96, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAP3K8, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK8, MAPK9, MYD88, NFKB1, NFKB2, NFKBIA, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, RAC1, RELA, RIPK1, SPP1, STAT1, TBK1, TICAM1, TICAM2, TIRAP, TLR1, TLR2, TLR3, TLR4, TLR5, TLR6, TLR7, TLR8, TLR9, TNF, TOLLIP, TRAF3, TRAF6 97 AKT1(4), AKT2(8), AKT3(3), CASP8(9), CD14(5), CD40(4), CD80(4), CD86(25), CHUK(2), CXCL10(3), CXCL11(1), CXCL9(3), FOS(2), IFNA1(1), IFNA10(2), IFNA13(1), IFNA14(8), IFNA16(11), IFNA17(2), IFNA2(1), IFNA21(7), IFNA4(1), IFNA5(4), IFNA6(2), IFNA7(6), IFNA8(3), IFNAR1(2), IFNAR2(14), IFNB1(6), IKBKB(4), IKBKE(10), IL12A(4), IL12B(3), IL1B(8), IL6(2), IL8(1), IRAK1(5), IRAK4(3), IRF3(3), IRF5(5), IRF7(5), JUN(1), LBP(9), LY96(4), MAP2K1(14), MAP2K2(5), MAP2K3(8), MAP2K4(4), MAP2K6(3), MAP2K7(5), MAP3K7(1), MAPK1(4), MAPK10(9), MAPK11(1), MAPK12(1), MAPK13(5), MAPK14(5), MAPK3(4), MAPK8(1), MAPK9(3), MYD88(3), NFKB1(6), NFKB2(3), NFKBIA(2), PIK3CA(10), PIK3CB(14), PIK3CD(8), PIK3CG(27), PIK3R1(2), PIK3R2(5), PIK3R3(2), PIK3R5(16), RELA(4), RIPK1(3), SPP1(7), STAT1(5), TBK1(4), TICAM1(9), TIRAP(1), TLR1(15), TLR2(15), TLR3(11), TLR4(41), TLR5(22), TLR6(7), TLR7(17), TLR8(14), TLR9(18), TNF(1), TOLLIP(1), TRAF3(5), TRAF6(4) 36352824 586 197 557 274 378 38 30 74 65 1 0.00228 1.000 1.000 92 HSA04916_MELANOGENESIS Genes involved in melanogenesis ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ASIP, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CREB1, CREB3, CREB3L1, CREB3L2, CREB3L3, CREB3L4, CREBBP, CTNNB1, DCT, DVL1, DVL2, DVL3, EDN1, EDNRB, EP300, FZD1, FZD10, FZD2, FZD3, FZD4, FZD5, FZD6, FZD7, FZD8, FZD9, GNAI1, GNAI2, GNAI3, GNAO1, GNAQ, GNAS, GSK3B, HRAS, KIT, KITLG, KRAS, LEF1, LOC652788, MAP2K1, MAP2K2, MAPK1, MAPK3, MC1R, MITF, NRAS, PLCB1, PLCB2, PLCB3, PLCB4, POMC, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, RAF1, TCF7, TCF7L1, TCF7L2, TYR, TYRP1, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT3A, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B, WNT8A, WNT8B, WNT9A, WNT9B 98 ADCY1(34), ADCY2(10), ADCY3(3), ADCY4(5), ADCY5(19), ADCY6(9), ADCY7(11), ADCY8(55), ADCY9(10), ASIP(2), CALM1(1), CALM2(1), CALML3(9), CALML6(1), CAMK2A(6), CAMK2B(6), CAMK2D(6), CAMK2G(5), CREB3(1), CREB3L1(5), CREB3L2(9), CREB3L3(10), CREB3L4(7), CREBBP(24), CTNNB1(14), DCT(4), DVL2(3), DVL3(8), EDN1(9), EDNRB(7), EP300(18), FZD1(5), FZD10(4), FZD2(6), FZD3(1), FZD4(1), FZD5(2), FZD6(2), FZD7(4), FZD8(5), FZD9(1), GNAI1(2), GNAI2(6), GNAI3(2), GNAO1(2), GNAQ(6), GNAS(25), GSK3B(3), HRAS(3), KIT(12), KITLG(11), KRAS(5), LEF1(3), MAP2K1(14), MAP2K2(5), MAPK1(4), MAPK3(4), MITF(6), PLCB1(54), PLCB2(12), PLCB3(4), PLCB4(86), POMC(4), PRKACA(3), PRKACB(4), PRKACG(11), PRKCA(8), PRKCG(16), PRKX(3), RAF1(10), TCF7(1), TCF7L1(4), TCF7L2(7), TYR(9), TYRP1(10), WNT1(2), WNT10A(7), WNT10B(6), WNT11(4), WNT16(3), WNT2(8), WNT2B(5), WNT3(5), WNT3A(9), WNT4(1), WNT5A(5), WNT5B(4), WNT6(3), WNT7A(14), WNT7B(6), WNT8A(7), WNT8B(7), WNT9A(3), WNT9B(6) 43906479 807 197 755 433 501 76 42 91 95 2 0.0115 1.000 1.000 93 ST_INTEGRIN_SIGNALING_PATHWAY Integrins are transmembrane receptors that mediate cell growth, survival, and migration by binding to ligands in the extracellular matrix. ABL1, ACK1, ACTN1, ACTR2, ACTR3, AKT1, AKT2, AKT3, ANGPTL2, ARHGEF6, ARHGEF7, BCAR1, BRAF, CAV1, CDC42, CDKN2A, CRK, CSE1L, DDEF1, DOCK1, EPHB2, FYN, GRAF, GRB2, GRB7, GRF2, GRLF1, ILK, ITGA1, ITGA10, ITGA11, ITGA2, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGB3BP, MAP2K4, MAP2K7, MAP3K11, MAPK1, MAPK10, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MRAS, MYLK, MYLK2, P4HB, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PIK3CA, PIK3CB, PKLR, PLCG1, PLCG2, PTEN, PTK2, RAF1, RALA, RHO, ROCK1, ROCK2, SHC1, SOS1, SOS2, SRC, TERF2IP, TLN1, TLN2, VASP, WAS, ZYX 75 ABL1(13), ACTN1(8), ACTR2(3), ACTR3(2), AKT1(4), AKT2(8), AKT3(3), ANGPTL2(2), ARHGEF6(10), ARHGEF7(6), BCAR1(5), CAV1(1), CDC42(2), CRK(3), CSE1L(5), DOCK1(17), EPHB2(34), FYN(7), GRB2(2), GRB7(9), ILK(2), ITGA1(24), ITGA10(12), ITGA11(19), ITGA2(13), ITGA3(8), ITGA4(43), ITGA5(25), ITGA6(10), ITGA7(25), ITGA8(37), ITGA9(13), ITGB3BP(3), MAP2K4(4), MAP2K7(5), MAP3K11(6), MAPK1(4), MAPK10(9), MAPK8(1), MAPK8IP1(7), MAPK8IP2(7), MAPK8IP3(10), MAPK9(3), MRAS(2), MYLK(46), MYLK2(12), P4HB(4), PAK1(4), PAK2(7), PAK3(10), PAK4(8), PAK6(6), PAK7(55), PIK3CA(10), PIK3CB(14), PKLR(13), PLCG1(8), PLCG2(27), PTK2(7), RAF1(10), RALA(1), RHO(2), ROCK1(7), ROCK2(11), SHC1(2), SOS1(10), SOS2(13), SRC(2), TERF2IP(1), TLN1(12), TLN2(27), VASP(3), WAS(8), ZYX(8) 48412375 784 197 745 373 505 63 30 98 87 1 0.00802 1.000 1.000 94 HSA04520_ADHERENS_JUNCTION Genes involved in adherens junction ACP1, ACTB, ACTG1, ACTN1, ACTN2, ACTN3, ACTN4, ACVR1B, ACVR1C, BAIAP2, CDC42, CDH1, CREBBP, CSNK2A1, CSNK2A2, CSNK2B, CTNNA1, CTNNA2, CTNNA3, CTNNB1, CTNND1, EGFR, EP300, ERBB2, FARP2, FER, FGFR1, FYN, IGF1R, INSR, IQGAP1, LEF1, LMO7, MAP3K7, MAPK1, MAPK3, MET, MLLT4, NLK, PARD3, PTPN1, PTPN6, PTPRB, PTPRF, PTPRJ, PTPRM, PVRL1, PVRL2, PVRL3, PVRL4, RAC1, RAC2, RAC3, RHOA, SMAD2, SMAD3, SMAD4, SNAI1, SNAI2, SORBS1, SRC, SSX2IP, TCF7, TCF7L1, TCF7L2, TGFBR1, TGFBR2, TJP1, VCL, WAS, WASF1, WASF2, WASF3, WASL, YES1 74 ACP1(4), ACTB(8), ACTG1(6), ACTN1(8), ACTN2(20), ACTN3(3), ACTN4(5), ACVR1B(3), ACVR1C(10), BAIAP2(7), CDC42(2), CDH1(5), CREBBP(24), CSNK2A1(4), CSNK2A2(1), CSNK2B(2), CTNNA1(3), CTNNA2(30), CTNNA3(38), CTNNB1(14), CTNND1(8), EGFR(25), EP300(18), ERBB2(9), FARP2(4), FER(3), FGFR1(11), FYN(7), IGF1R(14), INSR(26), IQGAP1(9), LEF1(3), LMO7(29), MAP3K7(1), MAPK1(4), MAPK3(4), MET(23), MLLT4(16), NLK(5), PARD3(18), PTPN1(4), PTPN6(5), PTPRB(89), PTPRF(32), PTPRJ(9), PTPRM(7), PVRL1(3), PVRL2(6), PVRL3(5), PVRL4(10), RAC2(3), RHOA(2), SMAD2(3), SMAD3(4), SMAD4(1), SNAI1(2), SNAI2(3), SORBS1(15), SRC(2), SSX2IP(4), TCF7(1), TCF7L1(4), TCF7L2(7), TGFBR2(9), TJP1(13), VCL(8), WAS(8), WASF1(4), WASF2(5), WASF3(13), WASL(5), YES1(4) 48809962 724 195 686 346 474 56 28 75 88 3 0.0537 1.000 1.000 95 HSA04660_T_CELL_RECEPTOR_SIGNALING_PATHWAY Genes involved in T cell receptor signaling pathway AKT1, AKT2, AKT3, BCL10, CARD11, CBL, CBLB, CBLC, CD247, CD28, CD3D, CD3E, CD3G, CD4, CD40LG, CD8A, CD8B, CDC42, CDK4, CHP, CHUK, CSF2, CTLA4, FOS, FYN, GRAP2, GRB2, HRAS, ICOS, IFNG, IKBKB, IKBKG, IL10, IL2, IL4, IL5, ITK, JUN, KRAS, LAT, LCK, LCP2, MALT1, MAP3K14, MAP3K8, NCK1, NCK2, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NRAS, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PDCD1, PDK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKCQ, PTPN6, PTPRC, RASGRP1, RHOA, SOS1, SOS2, TEC, TNF, VAV1, VAV2, VAV3, ZAP70 91 AKT1(4), AKT2(8), AKT3(3), BCL10(3), CARD11(38), CBL(10), CBLB(21), CBLC(15), CD247(4), CD28(2), CD3D(7), CD3E(2), CD3G(1), CD4(8), CD40LG(2), CD8A(2), CD8B(7), CDC42(2), CDK4(7), CHUK(2), CSF2(2), CTLA4(2), FOS(2), FYN(7), GRAP2(5), GRB2(2), HRAS(3), ICOS(2), IFNG(4), IKBKB(4), IL10(3), IL2(4), IL4(1), IL5(4), ITK(24), JUN(1), KRAS(5), LAT(2), LCK(15), LCP2(9), MALT1(8), MAP3K14(6), NCK1(2), NCK2(4), NFAT5(8), NFATC1(16), NFATC2(11), NFATC3(10), NFATC4(17), NFKB1(6), NFKB2(3), NFKBIA(2), NFKBIB(1), PAK1(4), PAK2(7), PAK3(10), PAK4(8), PAK6(6), PAK7(55), PDCD1(4), PDK1(2), PIK3CA(10), PIK3CB(14), PIK3CD(8), PIK3CG(27), PIK3R1(2), PIK3R2(5), PIK3R3(2), PIK3R5(16), PLCG1(8), PPP3CA(5), PPP3CB(3), PPP3CC(2), PPP3R2(5), PRKCQ(20), PTPN6(5), PTPRC(35), RASGRP1(11), RHOA(2), SOS1(10), SOS2(13), TEC(13), TNF(1), VAV1(19), VAV2(3), VAV3(14), ZAP70(7) 41179736 699 194 663 320 438 54 30 84 92 1 0.0226 1.000 1.000 96 HSA04012_ERBB_SIGNALING_PATHWAY Genes involved in ErbB signaling pathway ABL1, ABL2, AKT1, AKT2, AKT3, ARAF, AREG, BAD, BRAF, BTC, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CBL, CBLB, CBLC, CDKN1A, CDKN1B, CRK, CRKL, EGF, EGFR, EIF4EBP1, ELK1, ERBB2, ERBB3, ERBB4, EREG, FRAP1, GAB1, GRB2, GSK3B, HBEGF, HRAS, JUN, KRAS, MAP2K1, MAP2K2, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK3, MAPK8, MAPK9, MYC, NCK1, NCK2, NRAS, NRG1, NRG2, NRG3, NRG4, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PLCG2, PRKCA, PRKCB1, PRKCG, PTK2, RAF1, RPS6KB1, RPS6KB2, SHC1, SHC2, SHC3, SHC4, SOS1, SOS2, SRC, STAT5A, STAT5B, TGFA 83 ABL1(13), ABL2(11), AKT1(4), AKT2(8), AKT3(3), ARAF(5), AREG(8), BTC(2), CAMK2A(6), CAMK2B(6), CAMK2D(6), CAMK2G(5), CBL(10), CBLB(21), CBLC(15), CDKN1A(3), CDKN1B(1), CRK(3), CRKL(3), EGF(21), EGFR(25), EIF4EBP1(1), ELK1(3), ERBB2(9), ERBB3(5), ERBB4(54), EREG(3), GAB1(8), GRB2(2), GSK3B(3), HBEGF(1), HRAS(3), JUN(1), KRAS(5), MAP2K1(14), MAP2K2(5), MAP2K4(4), MAP2K7(5), MAPK1(4), MAPK10(9), MAPK3(4), MAPK8(1), MAPK9(3), MYC(5), NCK1(2), NCK2(4), NRG1(15), NRG2(7), NRG3(24), NRG4(1), PAK1(4), PAK2(7), PAK3(10), PAK4(8), PAK6(6), PAK7(55), PIK3CA(10), PIK3CB(14), PIK3CD(8), PIK3CG(27), PIK3R1(2), PIK3R2(5), PIK3R3(2), PIK3R5(16), PLCG1(8), PLCG2(27), PRKCA(8), PRKCG(16), PTK2(7), RAF1(10), RPS6KB1(3), RPS6KB2(2), SHC1(2), SHC2(6), SHC3(14), SHC4(2), SOS1(10), SOS2(13), SRC(2), STAT5A(3), STAT5B(6), TGFA(2) 41074315 699 191 659 317 443 51 32 86 86 1 0.0141 1.000 1.000 97 G_PROTEIN_SIGNALING ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, AKAP1, AKAP10, AKAP11, AKAP12, AKAP2, PALM2_AKAP2, AKAP3, AKAP4, AKAP5, AKAP6, AKAP7, AKAP8, AKAP9, ARHGEF1, CALM1, CALM2, CALM3, CHMP1B, GNA11, GNA12, GNA13, GNA14, GNA15, GNAI2, GNAI3, GNAL, GNAO1, GNAQ, GNAZ, GNB1, GNB2, GNB3, GNB5, GNG10, GNG10, LOC552891, GNG12, GNG13, GNG3, GNG4, GNG5, GNG7, GNGT1, GNGT2, HRAS, IL18BP, ITPR1, KCNJ3, KRAS, MGC11266, NRAS, PALM2, PALM2_AKAP2, PALM2_AKAP2, PDE1A, PDE1B, PDE1C, PDE4A, PDE4B, PDE4C, PDE4D, PDE7A, PDE7B, PDE8A, PDE8B, PLCB3, PPP3CA, PPP3CC, PRKACA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCI, PRKCQ, PRKCZ, PRKD1, PRKD3, RHOA, RRAS, SARA1, SLC9A1, USP5 90 ADCY1(34), ADCY2(10), ADCY3(3), ADCY4(5), ADCY5(19), ADCY6(9), ADCY7(11), ADCY8(55), ADCY9(10), AKAP1(10), AKAP10(2), AKAP11(13), AKAP12(6), AKAP3(17), AKAP4(19), AKAP6(39), AKAP7(2), AKAP8(7), AKAP9(34), ARHGEF1(1), CALM1(1), CALM2(1), CHMP1B(1), GNA11(8), GNA12(3), GNA13(1), GNA14(6), GNA15(6), GNAI2(6), GNAI3(2), GNAL(2), GNAO1(2), GNAQ(6), GNAZ(7), GNB1(1), GNB2(1), GNB3(7), GNB5(2), GNG4(3), GNG7(2), GNGT2(5), HRAS(3), ITPR1(36), KCNJ3(20), KRAS(5), PDE1B(16), PDE1C(52), PDE4A(11), PDE4B(8), PDE4C(19), PDE4D(7), PDE7A(1), PDE7B(16), PDE8A(3), PDE8B(22), PLCB3(4), PPP3CA(5), PPP3CC(2), PRKACA(3), PRKACB(4), PRKACG(11), PRKAR1A(3), PRKAR1B(4), PRKAR2A(1), PRKAR2B(5), PRKCA(8), PRKCD(5), PRKCE(6), PRKCG(16), PRKCH(9), PRKCI(8), PRKCQ(20), PRKCZ(7), PRKD1(9), PRKD3(6), RHOA(2), RRAS(1), SLC9A1(5), USP5(7) 46983656 749 189 724 444 505 61 36 70 77 0 0.432 1.000 1.000 98 INTRINSICPATHWAY The intrinsic prothrombin activation pathway is activated by traumatized blood vessels and induces clot formation. COL4A1, COL4A2, COL4A3, COL4A4, COL4A5, COL4A6, F10, F11, F12, F2, F2R, F5, F8, F9, FGA, FGB, FGG, KLKB1, KNG, PROC, PROS1, SERPINC1, SERPING1 22 COL4A1(64), COL4A2(35), COL4A3(44), COL4A4(114), COL4A5(68), COL4A6(42), F10(7), F11(12), F12(1), F2(11), F2R(8), F5(36), F8(49), F9(15), FGA(41), FGB(10), FGG(10), KLKB1(27), PROC(12), PROS1(18), SERPINC1(8), SERPING1(13) 18096211 645 188 600 176 473 40 20 56 55 1 0.000824 1.000 1.000 99 STARCH_AND_SUCROSE_METABOLISM AGL, AMY1A, AMY1B, AMY1C, AMY2A, AMY2B, AMY2B, RNPC3, ENPP1, ENPP3, G6PC, GAA, GANAB, GBA3, GBE1, GCK, GPI, GUSB, GYS1, GYS2, HK1, HK2, HK3, MGAM, PGM1, PGM3, PYGB, PYGL, PYGM, SI, UCHL1, UCHL3, UGDH, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4, UXS1 41 AGL(18), AMY2A(6), AMY2B(13), ENPP1(13), ENPP3(13), G6PC(5), GAA(8), GANAB(5), GBA3(19), GBE1(9), GCK(17), GPI(3), GUSB(5), GYS1(3), GYS2(24), HK1(3), HK2(13), HK3(14), MGAM(162), PGM1(6), PGM3(1), PYGB(3), PYGL(9), PYGM(12), SI(87), UCHL1(5), UCHL3(2), UGDH(1), UGT1A1(77), UGT2B15(31), UGT2B4(34), UXS1(4) 23116694 625 188 569 257 442 59 20 39 64 1 6.32e-06 1.000 1.000 100 HSA04350_TGF_BETA_SIGNALING_PATHWAY Genes involved in TGF-beta signaling pathway ACVR1, ACVR1B, ACVR1C, ACVR2A, ACVR2B, ACVRL1, AMH, AMHR2, BMP2, BMP4, BMP5, BMP6, BMP7, BMP8A, BMP8B, BMPR1A, BMPR1B, BMPR2, CDKN2B, CHRD, COMP, CREBBP, CUL1, DCN, E2F4, E2F5, EP300, FST, GDF5, GDF6, GDF7, hCG_1982709, ID1, ID2, ID3, ID4, IFNG, INHBA, INHBB, INHBC, INHBE, LEFTY1, LEFTY2, LTBP1, MAPK1, MAPK3, MYC, NODAL, NOG, PITX2, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, RBL1, RBL2, RBX1, RHOA, ROCK1, ROCK2, RPS6KB1, RPS6KB2, SKP1, SMAD1, SMAD2, SMAD3, SMAD4, SMAD5, SMAD6, SMAD7, SMAD9, SMURF1, SMURF2, SP1, TFDP1, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, THBS1, THBS2, THBS3, THBS4, TNF, ZFYVE16, ZFYVE9 88 ACVR1(2), ACVR1B(3), ACVR1C(10), ACVR2A(4), ACVR2B(3), ACVRL1(11), AMHR2(16), BMP2(7), BMP4(4), BMP5(32), BMP6(12), BMP7(5), BMP8A(2), BMPR1A(2), BMPR1B(4), BMPR2(6), CHRD(21), COMP(8), CREBBP(24), CUL1(5), DCN(18), E2F4(3), E2F5(3), EP300(18), FST(5), GDF5(16), GDF6(2), GDF7(2), ID1(1), ID2(2), IFNG(4), INHBA(19), INHBB(9), INHBC(12), INHBE(5), LEFTY1(6), LEFTY2(3), LTBP1(45), MAPK1(4), MAPK3(4), MYC(5), NODAL(2), NOG(2), PITX2(5), PPP2CB(2), PPP2R1A(4), PPP2R1B(3), PPP2R2B(6), PPP2R2C(8), RBL1(12), RBL2(6), RHOA(2), ROCK1(7), ROCK2(11), RPS6KB1(3), RPS6KB2(2), SMAD1(5), SMAD2(3), SMAD3(4), SMAD4(1), SMAD5(3), SMAD6(7), SMAD7(1), SMAD9(11), SMURF1(2), SMURF2(9), SP1(5), TFDP1(2), TGFB1(2), TGFB2(3), TGFB3(3), TGFBR2(9), THBS1(30), THBS2(12), THBS3(11), THBS4(19), TNF(1), ZFYVE16(5), ZFYVE9(9) 40469909 599 187 572 259 381 55 27 59 77 0 0.00948 1.000 1.000 101 PURINE_METABOLISM 1_Sep, ADA, ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADK, ADSL, ADSS, AK1, AK2, AK5, ALLC, AMPD1, AMPD2, AMPD3, APRT, ATIC, ATP1B1, ATP5A1, ATP5B, ATP5C1, ATP5D, ATP5F1, ATP5G1, ATP5G2, ATP5G3, ATP5H, ATP5I, ATP5J, ATP5J2, CANT1, DCK, DGUOK, ECGF1, ENPP1, ENPP3, ENTPD1, ENTPD2, FHIT, GART, GDA, GMPS, GUCY1A2, GUCY1A3, GUCY1B2, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, GUK1, HPRT1, IMPDH1, IMPDH2, ITPA, NME1, NME2, NP, NPR1, NPR2, NT5C, NT5E, NT5M, NUDT2, PAICS, PAPSS1, PAPSS2, PDE1A, PDE4A, PDE4B, PDE4C, PDE4D, PDE5A, PDE6B, PDE6C, PDE6G, PDE7B, PDE8A, PDE9A, PFAS, PKLR, PKM2, POLA, POLB, POLD1, POLD2, POLE, POLG, POLL, POLQ, POLR1B, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLRMT, POLS, PPAT, PRPS1, PRPS1L1, PRPS2, PRUNE, RRM1, RRM2, SAC 109 ADA(2), ADCY1(34), ADCY2(10), ADCY3(3), ADCY4(5), ADCY5(19), ADCY6(9), ADCY7(11), ADCY8(55), ADK(4), ADSL(5), ADSS(1), AK1(1), AK2(3), AK5(10), ALLC(6), AMPD1(34), AMPD2(7), AMPD3(25), APRT(3), ATIC(5), ATP1B1(2), ATP5A1(1), ATP5B(1), ATP5C1(3), ATP5F1(7), ATP5G2(3), ATP5H(3), ATP5J(2), CANT1(10), DGUOK(4), ENPP1(13), ENPP3(13), ENTPD1(12), ENTPD2(4), FHIT(2), GART(11), GDA(16), GMPS(6), GUCY1A2(21), GUCY1A3(32), GUCY1B3(7), GUCY2C(38), GUCY2D(9), GUCY2F(23), GUK1(3), IMPDH1(4), IMPDH2(1), ITPA(1), NPR1(18), NPR2(20), NT5E(6), NT5M(2), NUDT2(1), PAICS(1), PAPSS1(4), PAPSS2(5), PDE4A(11), PDE4B(8), PDE4C(19), PDE4D(7), PDE5A(10), PDE6B(16), PDE6C(24), PDE6G(2), PDE7B(16), PDE8A(3), PDE9A(11), PFAS(12), PKLR(13), PKM2(7), POLB(1), POLD1(7), POLD2(2), POLE(16), POLG(9), POLL(8), POLQ(25), POLR1B(9), POLR2A(13), POLR2B(12), POLR2C(1), POLR2D(1), POLR2E(3), POLR2F(1), POLR2H(2), POLR2J(1), POLRMT(3), PRPS1(2), PRPS1L1(13), PRPS2(2), PRUNE(3), RRM1(3), RRM2(3) 51658489 860 187 815 440 585 70 32 81 92 0 0.00143 1.000 1.000 102 PEPTIDE_GPCRS AGTR1, AGTR2, ATP8A1, AVPR1A, AVPR1B, AVPR2, BDKRB1, BDKRB2, BLR1, BRS3, C3AR1, C5R1, CCKAR, CCKBR, CCR1, CCR10, CCR2, CCR3, CCR4, CCR5, CCR6, CCR7, CCR8, CX3CR1, CXCR3, CXCR4, CXCR6, EDNRA, EDNRB, ELA3A, FPR1, FPRL1, FPRL2, FSHR, FY, GALR1, GALR2, GALR3, GALT, GHSR, GNB2L1, GNRHR, GPR77, GRPR, IL8RA, IL8RB, LHCGR, MC1R, MC2R, MC3R, MC4R, MC5R, NMBR, NPY1R, NPY2R, NPY5R, NPY6R, NTSR1, NTSR2, OPRD1, OPRK1, OPRL1, OPRM1, OXTR, PPYR1, SSTR1, SSTR2, SSTR3, SSTR4, TAC4, TACR1, TACR2, TACR3, TRHR, TSHR 66 AGTR1(10), AGTR2(9), ATP8A1(28), AVPR1A(4), AVPR1B(11), BDKRB1(6), BDKRB2(9), BRS3(5), C3AR1(5), CCKAR(11), CCKBR(11), CCR1(10), CCR10(3), CCR2(17), CCR3(10), CCR4(9), CCR5(10), CCR6(3), CCR7(4), CCR8(8), CX3CR1(17), CXCR3(4), CXCR4(3), CXCR6(4), EDNRA(10), EDNRB(7), FPR1(21), FSHR(19), GALR1(5), GALR3(2), GALT(2), GHSR(11), GNB2L1(4), GNRHR(2), GPR77(6), GRPR(7), LHCGR(27), MC2R(5), MC3R(7), MC4R(1), MC5R(8), NMBR(7), NPY1R(29), NPY2R(13), NPY5R(24), NTSR1(7), NTSR2(2), OPRD1(3), OPRK1(24), OPRL1(8), OPRM1(5), OXTR(5), PPYR1(14), SSTR1(10), SSTR2(7), SSTR3(11), SSTR4(4), TACR1(8), TACR2(7), TACR3(27), TRHR(23), TSHR(8) 21374892 601 186 562 410 416 56 27 55 47 0 0.000722 1.000 1.000 103 PHOSPHATIDYLINOSITOL_SIGNALING_SYSTEM ACVR1, ACVR1B, ACVRL1, AKT1, AURKB, BMPR1A, BMPR2, BUB1, CDC2L5, CDIPT, CDKL1, CDKL2, CDS1, CDS2, CLK1, CLK2, CLK4, COL4A3BP, CSNK2A1, CSNK2A1, CSNK2A1P, CSNK2A2, CSNK2B, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKQ, DGKZ, IMPA1, INPP1, INPP4A, INPP4B, INPP5A, INPPL1, ITPKA, ITPKB, MAP3K10, MOS, NEK1, NEK3, OCRL, PAK4, PCTK1, PCTK2, PIK3C2A, PIK3C2B, PIK3C2G, PIK3CA, PIK3CB, PIK3CG, PIK4CA, PIK4CA, LOC220686, PIM2, PIP5K2B, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCG1, PLCG2, PLK3, PRKACA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCQ, PRKCZ, PRKD1, PRKG1, RAF1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA4, RPS6KB1, STK11, TGFBR1, VRK1 82 ACVR1(2), ACVR1B(3), ACVRL1(11), AKT1(4), AURKB(2), BMPR1A(2), BMPR2(6), BUB1(6), CDKL1(5), CDKL2(2), CDS1(11), CDS2(5), CLK1(5), CLK2(8), COL4A3BP(3), CSNK2A1(4), CSNK2A2(1), CSNK2B(2), DGKA(3), DGKB(27), DGKD(14), DGKE(8), DGKG(18), DGKH(10), DGKQ(7), DGKZ(6), IMPA1(1), INPP1(3), INPP4A(7), INPP4B(2), INPP5A(4), INPPL1(16), ITPKB(11), MAP3K10(9), MOS(6), NEK1(7), NEK3(2), OCRL(6), PAK4(8), PIK3C2A(8), PIK3C2B(16), PIK3C2G(53), PIK3CA(10), PIK3CB(14), PIK3CG(27), PIM2(4), PLCB1(54), PLCB2(12), PLCB3(4), PLCB4(86), PLCD1(4), PLCG1(8), PLCG2(27), PLK3(3), PRKACA(3), PRKACB(4), PRKACG(11), PRKAR1A(3), PRKAR1B(4), PRKAR2A(1), PRKAR2B(5), PRKCA(8), PRKCD(5), PRKCE(6), PRKCG(16), PRKCH(9), PRKCQ(20), PRKCZ(7), PRKD1(9), PRKG1(14), RAF1(10), RPS6KA1(8), RPS6KA2(6), RPS6KA3(1), RPS6KA4(4), RPS6KB1(3), STK11(4), VRK1(1) 45762978 749 186 698 399 511 42 27 71 96 2 0.281 1.000 1.000 104 HSA04662_B_CELL_RECEPTOR_SIGNALING_PATHWAY Genes involved in B cell receptor signaling pathway AKT1, AKT2, AKT3, BCL10, BLNK, BTK, CARD11, CD19, CD22, CD72, CD79A, CD79B, CD81, CHP, CHUK, CR2, FCGR2B, FOS, GSK3B, HRAS, IFITM1, IKBKB, IKBKG, INPP5D, JUN, KRAS, LILRB3, LYN, MALT1, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NRAS, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG2, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKCB1, PTPN6, RAC1, RAC2, RAC3, RASGRP3, SYK, VAV1, VAV2, VAV3 60 AKT1(4), AKT2(8), AKT3(3), BCL10(3), BLNK(15), BTK(16), CARD11(38), CD19(8), CD22(23), CD72(5), CD79A(3), CD81(2), CHUK(2), CR2(34), FCGR2B(4), FOS(2), GSK3B(3), HRAS(3), IKBKB(4), INPP5D(37), JUN(1), KRAS(5), LILRB3(28), LYN(10), MALT1(8), NFAT5(8), NFATC1(16), NFATC2(11), NFATC3(10), NFATC4(17), NFKB1(6), NFKB2(3), NFKBIA(2), NFKBIB(1), PIK3CA(10), PIK3CB(14), PIK3CD(8), PIK3CG(27), PIK3R1(2), PIK3R2(5), PIK3R3(2), PIK3R5(16), PLCG2(27), PPP3CA(5), PPP3CB(3), PPP3CC(2), PPP3R2(5), PTPN6(5), RAC2(3), RASGRP3(12), SYK(14), VAV1(19), VAV2(3), VAV3(14) 30041861 539 181 517 240 341 34 28 58 76 2 0.00324 1.000 1.000 105 HISTONE_METHYLTRANSFERASE Genes with HMT activity AOF2, KDM6A, ASH1L, ASH2L, C17orf79, CARM1, CTCFL, DOT1L, EED, EHMT1, EHMT2, EZH1, EZH2, FBXL10, FBXL11, FBXO11, HCFC1, HSF4, JMJD1A, JMJD1B, JMJD2A, JMJD2B, JMJD2C, JMJD2D, JMJD3, JMJD4, JMJD6, MEN1, MLL, MLL2, MLL3, MLL4, MLL5, NSD1, OGT, PAXIP1, PPP1CA, PPP1CB, PPP1CC, PRDM2, PRDM6, PRDM7, PRDM9, PRMT1, PRMT5, PRMT6, PRMT7, PRMT8, RBBP5, SATB1, SETD1A, SETD1B, SETD2, SETD7, SETD8, SETDB1, SETDB2, SETMAR, SMYD3, STK38, SUV39H1, SUV39H2, SUV420H1, SUV420H2, SUZ12, WHSC1, WHSC1L1 55 ASH1L(34), ASH2L(4), CARM1(4), CTCFL(19), DOT1L(9), EED(3), EHMT1(10), EHMT2(11), EZH1(8), EZH2(11), FBXO11(7), HCFC1(19), JMJD4(4), JMJD6(1), KDM6A(2), MEN1(3), MLL(45), MLL2(91), MLL3(61), MLL5(12), NSD1(21), OGT(10), PAXIP1(3), PPP1CA(1), PPP1CB(5), PPP1CC(1), PRDM2(14), PRDM7(5), PRDM9(49), PRMT1(3), PRMT5(7), PRMT7(3), PRMT8(11), RBBP5(4), SATB1(20), SETD1A(23), SETD2(16), SETD7(1), SETD8(1), SETDB1(11), SETDB2(4), SETMAR(6), SMYD3(2), STK38(5), SUV39H1(1), SUV39H2(2), SUV420H1(6), SUV420H2(1), SUZ12(3), WHSC1(10), WHSC1L1(7) 48225202 614 179 593 236 395 64 22 71 62 0 0.0149 1.000 1.000 106 TRYPTOPHAN_METABOLISM AANAT, ABP1, ACAT1, ACAT2, ACMSD, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, AOC2, AOC3, AOX1, ASMT, CAT, CYP19A1, CYP1A1, CYP1A2, CYP2A6, CYP2A6, CYP2A7, CYP2A7P1, CYP2A13, CYP2B6, CYP2C18, CYP2C19, CYP2C19, CYP2C9, CYP2C8, CYP2C9, CYP2D6, CYP2E1, CYP2F1, CYP2J2, CYP3A4, CYP3A5, CYP3A7, CYP4B1, CYP4F8, CYP51A1, DDC, ECHS1, EHHADH, GCDH, HAAO, HADHA, INDO, KMO, KYNU, MAOA, MAOB, SDS, TDO2, TPH1, WARS, WARS2 54 AANAT(1), ABP1(22), ACAT2(1), ACMSD(13), ALDH1A1(5), ALDH1A2(14), ALDH1A3(2), ALDH1B1(11), ALDH2(7), ALDH3A1(8), ALDH3A2(3), ALDH9A1(2), AOC2(9), AOC3(10), AOX1(26), ASMT(9), CAT(8), CYP19A1(15), CYP1A1(9), CYP1A2(8), CYP2A13(12), CYP2A6(9), CYP2A7(10), CYP2B6(21), CYP2C19(75), CYP2C8(32), CYP2C9(38), CYP2D6(3), CYP2E1(13), CYP2F1(12), CYP2J2(7), CYP3A4(20), CYP3A7(30), CYP4B1(24), CYP4F8(18), CYP51A1(1), DDC(14), ECHS1(3), EHHADH(6), GCDH(6), HAAO(3), HADHA(6), KMO(8), KYNU(14), MAOA(4), MAOB(13), SDS(2), TDO2(4), TPH1(12), WARS(5), WARS2(4) 22391463 612 179 575 344 439 40 22 40 70 1 0.0312 1.000 1.000 107 GPCRDB_OTHER ADORA3, ALG6, C5R1, CCKBR, CCR2, CCR3, CCR5, CELSR1, CELSR2, CELSR3, CHRM2, CHRM3, CIDEB, CXCR3, DRD4, EBI2, EDG1, EDNRA, ELA3A, EMR2, EMR3, F2R, FSHR, FY, GHRHR, GNRHR, GPR, GPR116, GPR132, GPR133, GPR135, GPR143, GPR145, GPR17, GPR18, GPR55, GPR56, GPR61, GPR73L1, GPR77, GPR84, GPR88, GRCA, GRM1, GRPR, HRH4, IL8RA, IL8RB, LGR6, LGR7, LPHN2, LPHN3, LTB4R2, MASS1, NTSR1, OR2A9P, OR2M4, OR5E1P, OR7E19P, OR7E47P, OR7E37P, OR7E18P, OR7E35P, LOC441453, OR8G1, LOC442754, OR8G2, P2RY11, P2RY13, PTGFR, RLN3R1, SMO, SSTR2, TAAR5, TSHR, VN1R1 52 ADORA3(15), ALG6(2), CCKBR(11), CCR2(17), CCR3(10), CCR5(10), CELSR1(30), CELSR2(32), CELSR3(35), CHRM2(25), CHRM3(26), CXCR3(4), DRD4(1), EDNRA(10), EMR2(5), EMR3(21), F2R(8), FSHR(19), GHRHR(5), GNRHR(2), GPR116(36), GPR132(3), GPR133(13), GPR143(4), GPR17(1), GPR18(4), GPR55(6), GPR56(4), GPR61(7), GPR77(6), GPR84(8), GRM1(16), GRPR(7), HRH4(6), LGR6(21), LPHN2(46), LPHN3(22), NTSR1(7), OR2M4(14), OR8G1(9), OR8G2(19), P2RY13(4), PTGFR(21), SMO(10), SSTR2(7), TAAR5(4), TSHR(8), VN1R1(1) 27140361 602 177 569 383 398 51 23 69 60 1 0.0544 1.000 1.000 108 HSA00561_GLYCEROLIPID_METABOLISM Genes involved in glycerolipid metabolism ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AGK, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPAT6, AKR1A1, AKR1B1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, CEL, DAK, DGAT1, DGAT2, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKI, DGKQ, DGKZ, GK, GK2, GLA, GLB1, GPAM, LCT, LIPA, LIPC, LIPF, LIPG, LPL, LYCAT, MGLL, PNLIP, PNLIPRP1, PNLIPRP2, PNPLA3, PPAP2A, PPAP2B, PPAP2C, UGCGL1, UGCGL2 54 ADH1A(17), ADH1B(30), ADH1C(1), ADH4(10), ADH5(3), ADH6(14), ADH7(16), ADHFE1(6), AGK(8), AGPAT1(1), AGPAT2(2), AGPAT3(6), AGPAT4(6), AGPAT6(3), AKR1A1(3), AKR1B1(2), ALDH1A3(2), ALDH1B1(11), ALDH2(7), ALDH3A1(8), ALDH3A2(3), ALDH7A1(9), ALDH9A1(2), CEL(13), DAK(3), DGAT1(1), DGAT2(7), DGKA(3), DGKB(27), DGKD(14), DGKE(8), DGKG(18), DGKH(10), DGKI(31), DGKQ(7), DGKZ(6), GK(9), GLA(2), GLB1(9), GPAM(7), LCT(51), LIPA(5), LIPC(10), LIPF(18), LIPG(8), LPL(6), MGLL(8), PNLIP(9), PNLIPRP1(10), PNLIPRP2(3), PNPLA3(3), PPAP2A(1), PPAP2B(11), PPAP2C(8) 23497827 496 177 453 209 330 44 20 49 53 0 1.12e-05 1.000 1.000 109 HSA00562_INOSITOL_PHOSPHATE_METABOLISM Genes involved in inositol phosphate metabolism CARKL, FN3K, IMPA1, IMPA2, INPP1, INPP4A, INPP4B, INPP5A, INPP5B, INPP5E, INPPL1, IPMK, ISYNA1, ITGB1BP3, ITPK1, ITPKA, ITPKB, MINPP1, MIOX, OCRL, PI4KA, PI4KB, PIB5PA, PIK3C3, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIP4K2A, PIP4K2B, PIP4K2C, PIP5K1A, PIP5K1B, PIP5K1C, PIP5K3, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCD3, PLCD4, PLCE1, PLCG1, PLCG2, PLCZ1, PTEN, PTPMT1, SKIP, SYNJ1, SYNJ2 46 IMPA1(1), IMPA2(4), INPP1(3), INPP4A(7), INPP4B(2), INPP5A(4), INPP5B(6), INPPL1(16), IPMK(2), ISYNA1(1), ITGB1BP3(1), ITPK1(5), ITPKB(11), MINPP1(1), MIOX(4), OCRL(6), PI4KA(21), PI4KB(8), PIK3C3(3), PIK3CA(10), PIK3CB(14), PIK3CD(8), PIK3CG(27), PIP4K2A(6), PIP4K2B(3), PIP4K2C(2), PIP5K1A(6), PIP5K1B(21), PIP5K1C(9), PLCB1(54), PLCB2(12), PLCB3(4), PLCB4(86), PLCD1(4), PLCD3(4), PLCD4(4), PLCE1(57), PLCG1(8), PLCG2(27), PLCZ1(30), SYNJ1(20), SYNJ2(22) 29772196 544 177 509 244 368 25 26 56 67 2 0.000272 1.000 1.000 110 HSA03320_PPAR_SIGNALING_PATHWAY Genes involved in PPAR signaling pathway ACAA1, ACADL, ACADM, ACOX1, ACOX2, ACOX3, ACSL1, ACSL3, ACSL4, ACSL5, ACSL6, ADIPOQ, ANGPTL4, APOA1, APOA2, APOA5, APOC3, AQP7, CD36, CPT1A, CPT1B, CPT1C, CPT2, CYP27A1, CYP4A11, CYP4A22, CYP7A1, CYP8B1, DBI, EHHADH, FABP1, FABP2, FABP3, FABP4, FABP5, FABP5L1, FABP6, FABP7, FADS2, GK, GK2, HMGCS2, ILK, LOC642956, LPL, ME1, MMP1, NR1H3, OLR1, PCK1, PCK2, PDPK1, PLIN, PLTP, PPARA, PPARD, PPARG, RXRA, RXRB, RXRG, SCD, SCP2, SLC27A1, SLC27A2, SLC27A4, SLC27A5, SLC27A6, SORBS1, UBC, UCP1 66 ACAA1(6), ACADL(5), ACADM(4), ACOX1(8), ACOX2(6), ACOX3(13), ACSL1(8), ACSL3(8), ACSL4(5), ACSL5(27), ACSL6(12), ADIPOQ(5), ANGPTL4(5), APOA1(2), APOA5(5), APOC3(2), AQP7(3), CD36(6), CPT1A(14), CPT1B(8), CPT1C(17), CPT2(1), CYP27A1(3), CYP4A11(27), CYP4A22(23), CYP7A1(8), CYP8B1(13), DBI(1), EHHADH(6), FABP1(6), FABP2(8), FABP3(1), FABP4(1), FABP7(1), FADS2(4), GK(9), HMGCS2(21), ILK(2), LPL(6), ME1(20), MMP1(14), NR1H3(3), OLR1(5), PCK1(25), PCK2(6), PDPK1(3), PLTP(1), PPARA(7), PPARD(3), PPARG(14), RXRA(4), RXRB(4), RXRG(6), SCD(3), SCP2(4), SLC27A1(3), SLC27A2(16), SLC27A4(5), SLC27A5(9), SLC27A6(33), SORBS1(15), UBC(13), UCP1(5) 26310866 531 176 500 275 358 47 22 39 63 2 0.0295 1.000 1.000 111 CALCINEURIN_NF_AT_SIGNALING Mouse genes associated with signal transduction through calcium, calcineurin, and NF-AT. ACTB, BAD, BCL2, CABIN1, CALM1, CALM2, CALM3, CAMK2B, CAMK4, CD3E, CD3G, CD3Z, CD69, CDKN1A, CEBPB, CNR1, CREBBP, CSF2, CSNK2A1, CSNK2B, CTLA4, EGR2, EGR3, EP300, FCER1A, FCGR3A, FKBP1B, FLJ14639, FOS, FOSL1, GAPD, GATA3, GATA4, GRLF1, GSK3A, GSK3B, HRAS, ICOS, IFNA1, IFNB1, IFNG, IL10, IL13, IL1B, IL2, IL2RA, IL3, IL4, IL6, IL8, IL8RA, ITK, JUNB, KPNA5, KPNB3, MAP2K7, MAPK14, MAPK8, MAPK9, MEF2A, MEF2B, MEF2D, MYF5, NCK2, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NFKB2, NFKBIB, NFKBIE, NPPB, NUP214, OPRD1, P2RX7, PAK1, PIN1, PPIA, PPP3CB, PPP3CC, PPP3R1, PTPRC, RELA, RPL13A, SFN, SLA, SP1, SP3, TGFB1, TNF, TNFSF5, TNFSF6, TRAF2, TRPV6, VAV1, VAV2, VAV3, VEGF, XPO5 92 ACTB(8), BCL2(2), CABIN1(16), CALM1(1), CALM2(1), CAMK2B(6), CAMK4(17), CD3E(2), CD3G(1), CD69(4), CDKN1A(3), CNR1(13), CREBBP(24), CSF2(2), CSNK2A1(4), CSNK2B(2), CTLA4(2), EGR2(5), EGR3(4), EP300(18), FCER1A(15), FCGR3A(7), FOS(2), GATA3(8), GATA4(4), GSK3A(1), GSK3B(3), HRAS(3), ICOS(2), IFNA1(1), IFNB1(6), IFNG(4), IL10(3), IL13(2), IL1B(8), IL2(4), IL2RA(5), IL3(3), IL4(1), IL6(2), IL8(1), ITK(24), KPNA5(3), MAP2K7(5), MAPK14(5), MAPK8(1), MAPK9(3), MEF2A(3), MEF2B(2), MEF2D(6), MYF5(15), NCK2(4), NFAT5(8), NFATC1(16), NFATC2(11), NFATC3(10), NFATC4(17), NFKB2(3), NFKBIB(1), NPPB(6), NUP214(15), OPRD1(3), P2RX7(4), PAK1(4), PIN1(1), PPIA(1), PPP3CB(3), PPP3CC(2), PTPRC(35), RELA(4), RPL13A(2), SLA(4), SP1(5), SP3(1), TGFB1(2), TNF(1), TRAF2(2), TRPV6(30), VAV1(19), VAV2(3), VAV3(14), XPO5(7) 37155990 525 175 502 273 339 39 24 46 77 0 0.239 1.000 1.000 112 HSA04664_FC_EPSILON_RI_SIGNALING_PATHWAY Genes involved in Fc epsilon RI signaling pathway AKT1, AKT2, AKT3, BTK, CSF2, FCER1A, FCER1G, FYN, GAB2, GRB2, HRAS, IL13, IL3, IL4, IL5, INPP5D, KRAS, LAT, LCP2, LYN, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK8, MAPK9, MS4A2, NRAS, PDK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCG1, PLCG2, PRKCA, PRKCB1, PRKCD, PRKCE, RAC1, RAC2, RAC3, RAF1, SOS1, SOS2, SYK, TNF, VAV1, VAV2, VAV3 71 AKT1(4), AKT2(8), AKT3(3), BTK(16), CSF2(2), FCER1A(15), FCER1G(1), FYN(7), GAB2(4), GRB2(2), HRAS(3), IL13(2), IL3(3), IL4(1), IL5(4), INPP5D(37), KRAS(5), LAT(2), LCP2(9), LYN(10), MAP2K1(14), MAP2K2(5), MAP2K3(8), MAP2K4(4), MAP2K6(3), MAP2K7(5), MAPK1(4), MAPK10(9), MAPK11(1), MAPK12(1), MAPK13(5), MAPK14(5), MAPK3(4), MAPK8(1), MAPK9(3), PDK1(2), PIK3CA(10), PIK3CB(14), PIK3CD(8), PIK3CG(27), PIK3R1(2), PIK3R2(5), PIK3R3(2), PIK3R5(16), PLA2G12B(4), PLA2G1B(1), PLA2G2A(2), PLA2G2D(5), PLA2G2E(5), PLA2G2F(6), PLA2G3(17), PLA2G4A(15), PLA2G5(2), PLA2G6(12), PLCG1(8), PLCG2(27), PRKCA(8), PRKCD(5), PRKCE(6), RAC2(3), RAF1(10), SOS1(10), SOS2(13), SYK(14), TNF(1), VAV1(19), VAV2(3), VAV3(14) 28862656 506 175 478 214 310 35 19 63 77 2 0.000572 1.000 1.000 113 CELL_CYCLE_KEGG ABL1, ASK, ATM, BUB1, BUB1B, BUB3, CCNA1, CCNA2, CCNB1, CCNB2, CCNB3, CCND2, CCND3, CCNE1, CCNE2, CCNH, CDAN1, CDC14A, CDC14B, CDC14B, CDC14C, CDC2, CDC20, CDC25A, CDC25B, CDC25C, CDC45L, CDC6, CDC7, CDH1, CDK2, CDK4, CDKN1A, CDKN2A, CHEK1, CHEK2, DTX4, E2F1, E2F2, E2F3, E2F4, E2F5, E2F6, EP300, ESPL1, FLJ14001, GADD45A, GSK3B, HDAC1, HDAC2, HDAC3, HDAC4, HDAC5, HDAC6, HDAC7A, HDAC8, MAD1L1, MAD2L1, MAD2L2, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, MDM2, MPEG1, MPL, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, PLK1, PRKDC, PTPRA, PTTG1, PTTG2, PTTG3, RB1, RBL1, SKP2, SMAD4, SMC1L1, TBC1D8, TFDP1, TGFB1, TP53, WEE1 80 ABL1(13), ATM(15), BUB1(6), BUB1B(10), BUB3(1), CCNA1(14), CCNB2(2), CCNB3(31), CCND2(6), CCND3(2), CCNE1(4), CCNE2(8), CCNH(2), CDAN1(6), CDC14A(6), CDC14B(3), CDC20(1), CDC25A(8), CDC25B(4), CDC25C(5), CDC6(2), CDC7(2), CDH1(5), CDK4(7), CDKN1A(3), CHEK1(2), CHEK2(2), DTX4(4), E2F1(5), E2F2(5), E2F3(5), E2F4(3), E2F5(3), E2F6(1), EP300(18), ESPL1(20), GSK3B(3), HDAC1(2), HDAC2(2), HDAC3(5), HDAC4(11), HDAC5(6), HDAC6(2), HDAC8(5), MAD1L1(6), MAD2L1(1), MAD2L2(1), MCM2(11), MCM3(9), MCM4(8), MCM5(5), MCM6(5), MCM7(1), MDM2(1), MPEG1(6), MPL(8), PCNA(2), PLK1(4), PRKDC(19), PTPRA(9), PTTG1(1), PTTG2(4), RB1(10), RBL1(12), SKP2(2), SMAD4(1), TBC1D8(10), TFDP1(2), TGFB1(2), WEE1(2) 44141999 412 173 403 187 247 42 22 57 42 2 0.0536 1.000 1.000 114 HSA00150_ANDROGEN_AND_ESTROGEN_METABOLISM Genes involved in androgen and estrogen metabolism AKR1C4, AKR1D1, ARSD, ARSE, CARM1, CYP11B1, CYP11B2, CYP19A1, HEMK1, HSD11B1, HSD11B2, HSD17B1, HSD17B12, HSD17B2, HSD17B3, HSD17B7, HSD17B8, HSD3B1, HSD3B2, LCMT1, LCMT2, METTL2B, METTL6, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, SRD5A1, SRD5A2, STS, SULT1E1, SULT2A1, SULT2B1, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, WBSCR22 52 AKR1C4(10), AKR1D1(19), ARSD(3), ARSE(5), CARM1(4), CYP11B1(18), CYP11B2(14), CYP19A1(15), HEMK1(4), HSD11B2(3), HSD17B12(3), HSD17B2(12), HSD17B3(5), HSD17B7(1), HSD3B1(14), HSD3B2(14), LCMT1(4), LCMT2(1), METTL2B(7), METTL6(1), PRMT2(2), PRMT3(5), PRMT5(7), PRMT7(3), PRMT8(11), SRD5A1(2), SRD5A2(6), STS(7), SULT1E1(16), SULT2A1(9), SULT2B1(7), UGT1A1(77), UGT2A3(28), UGT2B10(45), UGT2B11(23), UGT2B15(31), UGT2B17(29), UGT2B28(26), UGT2B4(34), UGT2B7(19), WBSCR22(1) 19684000 545 173 498 222 378 50 18 31 67 1 2.08e-07 1.000 1.000 115 HSA04320_DORSO_VENTRAL_AXIS_FORMATION Genes involved in dorso-ventral axis formation BRAF, CPEB1, EGFR, ERBB2, ERBB4, ETS1, ETS2, ETV6, ETV7, FMN2, GRB2, KRAS, MAP2K1, MAPK1, MAPK3, NOTCH1, NOTCH2, NOTCH3, NOTCH4, PIWIL1, PIWIL2, PIWIL3, PIWIL4, RAF1, SOS1, SOS2, SPIRE1, SPIRE2 27 CPEB1(10), EGFR(25), ERBB2(9), ERBB4(54), ETS1(4), ETS2(8), ETV6(10), ETV7(5), FMN2(83), GRB2(2), KRAS(5), MAP2K1(14), MAPK1(4), MAPK3(4), NOTCH1(9), NOTCH2(33), NOTCH3(26), NOTCH4(62), PIWIL1(22), PIWIL2(13), PIWIL3(15), PIWIL4(4), RAF1(10), SOS1(10), SOS2(13), SPIRE1(2), SPIRE2(7) 20788659 463 172 441 199 311 27 14 66 43 2 0.0690 1.000 1.000 116 ACE2PATHWAY Angiotensin-converting enzyme 2 (ACE2) digests the blood-pressure regulator angiotensin II (AGT) ultimately to the vasodilator AGT1-7. ACE2, AGT, AGTR1, AGTR2, CMA1, COL4A1, COL4A2, COL4A3, COL4A4, COL4A5, COL4A6, REN 12 ACE2(5), AGT(8), AGTR1(10), AGTR2(9), CMA1(5), COL4A1(64), COL4A2(35), COL4A3(44), COL4A4(114), COL4A5(68), COL4A6(42), REN(11) 10269373 415 170 386 106 317 19 8 25 45 1 0.0870 1.000 1.000 117 MRNA_PROCESSING_REACTOME BRUNOL4, C10orf9, C20orf14, CD2BP2, CDC40, CLK2, CLK3, CLK4, COL2A1, CPSF1, CPSF2, CPSF3, CPSF4, CSTF1, CSTF2, CSTF2T, CSTF3, CUGBP1, CUGBP2, DDIT3, DDX1, DDX20, DHX15, DHX16, DHX38, DHX8, DHX9, DICER1, DNAJC8, FLJ10748, FNBP3, FUS, FUSIP1, GIPC1, HEAB, HNRPA2B1, HNRPA3, HNRPA3P1, HNRPA3, LOC387933, HNRPA3P1, HNRPA3, LOC389395, HNRPAB, HNRPC, HNRPC, HNRPCL1, LOC390615, LOC440563, HNRPD, HNRPH1, HNRPH2, HNRPL, HNRPR, HNRPU, HRMT1L2, LSM2, LSM7, METTL3, NCBP1, NCBP2, NONO, NUDT21, NXF1, PABPN1, PAPOLA, PHF5A, POLR2A, PPM1G, PRPF18, PRPF3, PRPF4, PRPF4B, PRPF8, PSKH1, PTBP1, PTBP2, RBM17, RBM5, RNGTT, RNMT, RNPC2, RNPS1, SF3A1, SF3A2, SF3A3, SF3B1, SF3B2, SF3B4, SF3B5, SF4, SFRS10, SFRS12, SFRS14, SFRS16, SFRS2, SFRS4, SFRS5, SFRS6, SFRS7, SFRS8, SFRS9, SMC1L1, SNRP70, SNRPA, SNRPA1, SNRPB, SNRPB2, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF, SNRPG, SNRPN, SNRPN, PAR1, SNRPN, SNURF, SPOP, SRPK1, SRPK2, SRRM1, SUPT5H, TMP21, TXNL4A, U2AF1, U2AF2, WDR57, XRN2 92 CD2BP2(2), CDC40(7), CLK2(8), CLK3(2), COL2A1(42), CPSF1(8), CPSF2(2), CPSF3(3), CPSF4(1), CSTF1(6), CSTF2(4), CSTF2T(3), CSTF3(5), DDIT3(2), DDX1(2), DDX20(11), DHX15(6), DHX16(10), DHX38(9), DHX8(10), DHX9(11), DICER1(22), DNAJC8(2), FUS(1), GIPC1(4), LOC440563(26), LSM7(1), METTL3(2), NCBP1(1), NONO(10), NUDT21(3), NXF1(5), PAPOLA(4), PHF5A(3), POLR2A(13), PPM1G(2), PRPF18(4), PRPF3(5), PRPF4(3), PRPF4B(6), PRPF8(15), PSKH1(2), PTBP1(3), PTBP2(6), RBM17(1), RBM5(9), RNGTT(2), RNMT(9), RNPS1(2), SF3A1(7), SF3A2(6), SF3A3(6), SF3B1(16), SF3B2(11), SF3B4(7), SNRPA(2), SNRPA1(2), SNRPB(6), SNRPB2(2), SNRPD1(1), SNRPE(1), SNRPN(14), SPOP(2), SRPK1(9), SRPK2(2), SRRM1(8), SUPT5H(7), TXNL4A(1), U2AF2(5), XRN2(6) 43382059 441 169 431 169 259 37 28 54 63 0 0.0423 1.000 1.000 118 HSA04742_TASTE_TRANSDUCTION Genes involved in taste transduction ACCN1, ADCY4, ADCY6, ADCY8, CACNA1A, CACNA1B, GNAS, GNAT3, GNB1, GNB3, GNG13, GNG3, GRM4, ITPR3, KCNB1, PDE1A, PLCB2, PRKACA, PRKACB, PRKACG, PRKX, PRKY, SCNN1A, SCNN1B, SCNN1G, TAS1R1, TAS1R2, TAS1R3, TAS2R1, TAS2R10, TAS2R13, TAS2R14, TAS2R16, TAS2R3, TAS2R38, TAS2R39, TAS2R4, TAS2R40, TAS2R41, TAS2R42, TAS2R43, TAS2R44, TAS2R45, TAS2R46, TAS2R48, TAS2R49, TAS2R5, TAS2R50, TAS2R60, TAS2R7, TAS2R8, TAS2R9, TRPM5 47 ADCY4(5), ADCY6(9), ADCY8(55), CACNA1A(38), CACNA1B(35), GNAS(25), GNAT3(5), GNB1(1), GNB3(7), GRM4(21), ITPR3(11), KCNB1(38), PLCB2(12), PRKACA(3), PRKACB(4), PRKACG(11), PRKX(3), SCNN1A(9), SCNN1B(14), SCNN1G(32), TAS1R1(13), TAS1R2(23), TAS1R3(2), TAS2R1(8), TAS2R10(8), TAS2R13(2), TAS2R14(3), TAS2R16(10), TAS2R3(2), TAS2R38(18), TAS2R39(13), TAS2R4(4), TAS2R40(4), TAS2R41(12), TAS2R42(2), TAS2R43(2), TAS2R46(3), TAS2R5(4), TAS2R50(2), TAS2R60(19), TAS2R7(5), TAS2R8(5), TAS2R9(9), TRPM5(14) 22601463 525 167 498 434 346 39 27 54 59 0 0.931 1.000 1.000 119 NFATPATHWAY Cardiac hypertrophy is induced by NF-ATc4 and GATA4, which are stimulated through calcineurin activated by CaMK. ACTA1, AGT, AKT1, CALM1, CALM2, CALM3, CALR, CAMK1, CAMK1G, CAMK4, CREBBP, CSNK1A1, CTF1, DTR, EDN1, ELSPBP1, F2, FGF2, FKBP1A, GATA4, GSK3B, HAND1, HAND2, HRAS, IGF1, LIF, MAP2K1, MAPK1, MAPK14, MAPK3, MAPK8, MEF2C, MYH2, NFATC1, NFATC2, NFATC3, NFATC4, NKX2-5, NPPA, PIK3CA, PIK3R1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RAF1, RPS6KB1, SYT1 51 ACTA1(4), AGT(8), AKT1(4), CALM1(1), CALM2(1), CALR(2), CAMK1(5), CAMK1G(11), CAMK4(17), CREBBP(24), CSNK1A1(3), EDN1(9), ELSPBP1(8), F2(11), FGF2(1), GATA4(4), GSK3B(3), HAND1(2), HAND2(5), HRAS(3), IGF1(10), LIF(1), MAP2K1(14), MAPK1(4), MAPK14(5), MAPK3(4), MAPK8(1), MEF2C(4), MYH2(97), NFATC1(16), NFATC2(11), NFATC3(10), NFATC4(17), NKX2-5(1), NPPA(4), PIK3CA(10), PIK3R1(2), PPP3CA(5), PPP3CB(3), PPP3CC(2), PRKACB(4), PRKACG(11), PRKAR1A(3), PRKAR1B(4), PRKAR2A(1), PRKAR2B(5), RAF1(10), RPS6KB1(3), SYT1(23) 20747274 411 165 379 219 274 37 17 36 46 1 0.341 1.000 1.000 120 HSA04210_APOPTOSIS Genes involved in apoptosis AIFM1, AKT1, AKT2, AKT3, APAF1, ATM, BAD, BAX, BCL2, BCL2L1, BID, BIRC2, BIRC3, BIRC4, CAPN1, CAPN2, CASP10, CASP3, CASP6, CASP7, CASP8, CASP9, CFLAR, CHP, CHUK, CSF2RB, CYCS, DFFA, DFFB, ENDOG, FADD, FAS, FASLG, IKBKB, IKBKG, IL1A, IL1B, IL1R1, IL1RAP, IL3, IL3RA, IRAK1, IRAK2, IRAK3, IRAK4, MAP3K14, MYD88, NFKB1, NFKB2, NFKBIA, NGFB, NTRK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKACA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RELA, RIPK1, TNF, TNFRSF10A, TNFRSF10B, TNFRSF10C, TNFRSF10D, TNFRSF1A, TNFSF10, TP53, TRADD, TRAF2 79 AIFM1(3), AKT1(4), AKT2(8), AKT3(3), APAF1(6), ATM(15), BAX(3), BCL2(2), BIRC2(6), BIRC3(7), CAPN1(4), CAPN2(5), CASP10(6), CASP3(2), CASP7(4), CASP8(9), CASP9(2), CFLAR(4), CHUK(2), CSF2RB(24), CYCS(1), DFFA(2), DFFB(2), FAS(6), FASLG(15), IKBKB(4), IL1A(5), IL1B(8), IL1R1(13), IL1RAP(3), IL3(3), IL3RA(7), IRAK1(5), IRAK2(15), IRAK3(10), IRAK4(3), MAP3K14(6), MYD88(3), NFKB1(6), NFKB2(3), NFKBIA(2), NTRK1(16), PIK3CA(10), PIK3CB(14), PIK3CD(8), PIK3CG(27), PIK3R1(2), PIK3R2(5), PIK3R3(2), PIK3R5(16), PPP3CA(5), PPP3CB(3), PPP3CC(2), PPP3R2(5), PRKACA(3), PRKACB(4), PRKACG(11), PRKAR1A(3), PRKAR1B(4), PRKAR2A(1), PRKAR2B(5), RELA(4), RIPK1(3), TNF(1), TNFRSF10A(7), TNFRSF10B(4), TNFRSF10C(4), TNFRSF10D(9), TNFRSF1A(4), TNFSF10(8), TRAF2(2) 33575207 433 164 420 229 270 28 20 56 58 1 0.501 1.000 1.000 121 HSA04370_VEGF_SIGNALING_PATHWAY Genes involved in VEGF signaling pathway AKT1, AKT2, AKT3, BAD, CASP9, CDC42, CHP, HRAS, KDR, KRAS, MAP2K1, MAP2K2, MAPK1, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPKAPK2, MAPKAPK3, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NOS3, NRAS, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCG1, PLCG2, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKCA, PRKCB1, PRKCG, PTGS2, PTK2, PXN, RAC1, RAC2, RAC3, RAF1, SH2D2A, SHC2, SPHK1, SPHK2, SRC, VEGFA 67 AKT1(4), AKT2(8), AKT3(3), CASP9(2), CDC42(2), HRAS(3), KDR(55), KRAS(5), MAP2K1(14), MAP2K2(5), MAPK1(4), MAPK11(1), MAPK12(1), MAPK13(5), MAPK14(5), MAPK3(4), MAPKAPK2(5), MAPKAPK3(5), NFAT5(8), NFATC1(16), NFATC2(11), NFATC3(10), NFATC4(17), NOS3(19), PIK3CA(10), PIK3CB(14), PIK3CD(8), PIK3CG(27), PIK3R1(2), PIK3R2(5), PIK3R3(2), PIK3R5(16), PLA2G12B(4), PLA2G1B(1), PLA2G2A(2), PLA2G2D(5), PLA2G2E(5), PLA2G2F(6), PLA2G3(17), PLA2G4A(15), PLA2G5(2), PLA2G6(12), PLCG1(8), PLCG2(27), PPP3CA(5), PPP3CB(3), PPP3CC(2), PPP3R2(5), PRKCA(8), PRKCG(16), PTGS2(13), PTK2(7), PXN(2), RAC2(3), RAF1(10), SH2D2A(4), SHC2(6), SPHK1(2), SPHK2(7), SRC(2), VEGFA(4) 29071194 499 164 475 214 322 30 16 62 67 2 0.000589 1.000 1.000 122 MAPKPATHWAY The mitogen-activated protein (MAP) kinase pathway is a common signaling mechanism and has four main sub-pathways: Erk, JNK/SAPK, p53, and ERK5. ARAF1, ATF2, BRAF, CEBPA, CHUK, CREB1, DAXX, ELK1, FOS, GRB2, HRAS, IKBKB, JUN, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K5, MAP2K6, MAP2K7, MAP3K1, MAP3K10, MAP3K11, MAP3K12, MAP3K13, MAP3K14, MAP3K2, MAP3K3, MAP3K4, MAP3K5, MAP3K6, MAP3K7, MAP3K8, MAP3K9, MAP4K1, MAP4K2, MAP4K3, MAP4K4, MAP4K5, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK4, MAPK6, MAPK7, MAPK8, MAPK9, MAPKAPK2, MAPKAPK3, MAPKAPK5, MAX, MEF2A, MEF2B, MEF2C, MEF2D, MKNK1, MKNK2, MYC, NFKB1, NFKBIA, PAK1, PAK2, PDZGEF1, RAC1, RAF1, RELA, RIPK1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA4, RPS6KA5, RPS6KB1, RPS6KB2, SHC1, SP1, STAT1, TGFB1, TGFB2, TGFB3, TGFBR1, TRADD, TRAF2 82 ATF2(6), CHUK(2), DAXX(9), ELK1(3), FOS(2), GRB2(2), HRAS(3), IKBKB(4), JUN(1), MAP2K1(14), MAP2K2(5), MAP2K3(8), MAP2K4(4), MAP2K5(4), MAP2K6(3), MAP2K7(5), MAP3K1(4), MAP3K10(9), MAP3K11(6), MAP3K12(3), MAP3K13(15), MAP3K14(6), MAP3K2(6), MAP3K3(8), MAP3K4(17), MAP3K5(23), MAP3K6(5), MAP3K7(1), MAP3K9(26), MAP4K1(11), MAP4K2(7), MAP4K3(11), MAP4K4(16), MAP4K5(4), MAPK1(4), MAPK10(9), MAPK11(1), MAPK12(1), MAPK13(5), MAPK14(5), MAPK3(4), MAPK4(18), MAPK6(7), MAPK7(4), MAPK8(1), MAPK9(3), MAPKAPK2(5), MAPKAPK3(5), MAPKAPK5(1), MEF2A(3), MEF2B(2), MEF2C(4), MEF2D(6), MKNK1(6), MKNK2(3), MYC(5), NFKB1(6), NFKBIA(2), PAK1(4), PAK2(7), RAF1(10), RELA(4), RIPK1(3), RPS6KA1(8), RPS6KA2(6), RPS6KA3(1), RPS6KA4(4), RPS6KA5(7), RPS6KB1(3), RPS6KB2(2), SHC1(2), SP1(5), STAT1(5), TGFB1(2), TGFB2(3), TGFB3(3), TRAF2(2) 37717247 444 164 428 217 262 46 23 62 51 0 0.301 1.000 1.000 123 ST_G_ALPHA_I_PATHWAY Gi and Go proteins are members of the same family that transduce cellular signals through both their alpha and beta subunits. AKT1, AKT2, AKT3, ASAH1, BF, BRAF, DAG1, DRD2, EGFR, EPHB2, GRB2, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, KCNJ3, KCNJ5, KCNJ9, MAPK1, PI3, PIK3CB, PITX2, PLCB1, PLCB2, PLCB3, PLCB4, RAF1, RAP1GA1, RGS20, SHC1, SOS1, SOS2, SRC, STAT3, TERF2IP 33 AKT1(4), AKT2(8), AKT3(3), DAG1(9), DRD2(14), EGFR(25), EPHB2(34), GRB2(2), ITPKB(11), ITPR1(36), ITPR2(20), ITPR3(11), KCNJ3(20), KCNJ5(13), KCNJ9(6), MAPK1(4), PI3(6), PIK3CB(14), PITX2(5), PLCB1(54), PLCB2(12), PLCB3(4), PLCB4(86), RAF1(10), RGS20(2), SHC1(2), SOS1(10), SOS2(13), SRC(2), STAT3(9), TERF2IP(1) 23217872 450 164 416 240 299 37 22 43 47 2 0.0727 1.000 1.000 124 HSA04920_ADIPOCYTOKINE_SIGNALING_PATHWAY Genes involved in adipocytokine signaling pathway ACACB, ACSL1, ACSL3, ACSL4, ACSL5, ACSL6, ADIPOQ, ADIPOR1, ADIPOR2, AGRP, AKT1, AKT2, AKT3, CAMKK1, CAMKK2, CD36, CHUK, CPT1A, CPT1B, CPT1C, CPT2, FRAP1, G6PC, G6PC2, IKBKB, IKBKG, IRS1, IRS2, IRS4, JAK1, JAK2, JAK3, LEP, LEPR, MAPK10, MAPK8, MAPK9, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NPY, PCK1, PCK2, POMC, PPARA, PPARGC1A, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKAG1, PRKAG2, PRKAG3, PRKCQ, PTPN11, RELA, RXRA, RXRB, RXRG, SLC2A1, SLC2A4, SOCS3, STAT3, STK11, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF2, TYK2 70 ACACB(23), ACSL1(8), ACSL3(8), ACSL4(5), ACSL5(27), ACSL6(12), ADIPOQ(5), ADIPOR1(5), ADIPOR2(1), AGRP(1), AKT1(4), AKT2(8), AKT3(3), CAMKK1(3), CAMKK2(9), CD36(6), CHUK(2), CPT1A(14), CPT1B(8), CPT1C(17), CPT2(1), G6PC(5), G6PC2(4), IKBKB(4), IRS1(5), IRS2(3), IRS4(13), JAK1(6), JAK2(8), JAK3(11), LEP(4), LEPR(29), MAPK10(9), MAPK8(1), MAPK9(3), NFKB1(6), NFKB2(3), NFKBIA(2), NFKBIB(1), NPY(4), PCK1(25), PCK2(6), POMC(4), PPARA(7), PPARGC1A(23), PRKAA1(1), PRKAA2(30), PRKAB1(2), PRKAB2(2), PRKAG1(3), PRKAG2(8), PRKAG3(10), PRKCQ(20), PTPN11(10), RELA(4), RXRA(4), RXRB(4), RXRG(6), SLC2A1(5), SLC2A4(9), SOCS3(1), STAT3(9), STK11(4), TNF(1), TNFRSF1A(4), TNFRSF1B(4), TRAF2(2), TYK2(8) 33865419 507 163 489 272 320 48 22 51 66 0 0.232 1.000 1.000 125 VITCBPATHWAY Vitamin C (ascorbic acid), in addition to its role in collagen modification, serves as an antioxidant and is imported into cells by Svct2 in the brain and Svct1 in intestinal epithelium. COL4A1, COL4A2, COL4A3, COL4A4, COL4A5, COL4A6, P4HB, SLC23A1, SLC23A2, SLC2A1, SLC2A3 11 COL4A1(64), COL4A2(35), COL4A3(44), COL4A4(114), COL4A5(68), COL4A6(42), P4HB(4), SLC23A1(5), SLC23A2(2), SLC2A1(5), SLC2A3(7) 10153043 390 162 363 85 299 16 10 26 38 1 0.000805 1.000 1.000 126 GLYCEROLIPID_METABOLISM ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AKR1A1, AKR1B1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, CEL, DGAT1, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKQ, DGKZ, GK, GLA, GLB1, LCT, LIPC, LIPF, LIPG, LPL, PNLIP, PNLIPRP1, PNLIPRP2, PPAP2A, PPAP2B, PPAP2C 45 ADH1A(17), ADH1B(30), ADH1C(1), ADH4(10), ADH6(14), ADH7(16), ADHFE1(6), AGPAT1(1), AGPAT2(2), AGPAT3(6), AGPAT4(6), AKR1A1(3), AKR1B1(2), ALDH1A1(5), ALDH1A2(14), ALDH1A3(2), ALDH1B1(11), ALDH2(7), ALDH3A1(8), ALDH3A2(3), ALDH9A1(2), CEL(13), DGAT1(1), DGKA(3), DGKB(27), DGKD(14), DGKE(8), DGKG(18), DGKH(10), DGKQ(7), DGKZ(6), GK(9), GLA(2), GLB1(9), LCT(51), LIPC(10), LIPF(18), LIPG(8), LPL(6), PNLIP(9), PNLIPRP1(10), PNLIPRP2(3), PPAP2A(1), PPAP2B(11), PPAP2C(8) 19656505 428 161 389 187 296 36 16 37 43 0 9.81e-05 1.000 1.000 127 HSA00010_GLYCOLYSIS_AND_GLUCONEOGENESIS Genes involved in glycolysis and gluconeogenesis ACSS1, ACSS2, ACYP1, ACYP2, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AKR1A1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH7A1, ALDH9A1, ALDOA, ALDOB, ALDOC, BPGM, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, G6PC2, GALM, GAPDH, GAPDHS, GCK, GPI, HK1, HK2, HK3, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, PDHA1, PDHA2, PDHB, PFKL, PFKM, PFKP, PGAM1, PGAM2, PGAM4, PGK1, PGK2, PGM1, PGM3, PKLR, PKM2, TPI1 64 ACSS1(2), ACSS2(4), ACYP1(1), ADH1A(17), ADH1B(30), ADH1C(1), ADH4(10), ADH5(3), ADH6(14), ADH7(16), ADHFE1(6), AKR1A1(3), ALDH1A3(2), ALDH1B1(11), ALDH2(7), ALDH3A1(8), ALDH3A2(3), ALDH3B1(3), ALDH3B2(8), ALDH7A1(9), ALDH9A1(2), ALDOA(2), ALDOB(14), ALDOC(4), BPGM(3), DLAT(4), DLD(3), ENO1(4), ENO2(5), ENO3(3), FBP1(3), FBP2(2), G6PC(5), G6PC2(4), GALM(2), GAPDH(2), GAPDHS(3), GCK(17), GPI(3), HK1(3), HK2(13), HK3(14), LDHA(4), LDHAL6A(4), LDHAL6B(6), LDHB(2), LDHC(5), PDHA1(4), PDHA2(20), PDHB(1), PFKL(4), PFKM(2), PFKP(2), PGAM2(3), PGK1(2), PGK2(35), PGM1(6), PGM3(1), PKLR(13), PKM2(7), TPI1(1) 23745708 395 161 362 183 267 28 23 37 40 0 0.000366 1.000 1.000 128 NO1PATHWAY Shear stress in endothelial cells increases cytoplasmic calcium, which activates nitric oxide synthase III to release NO, which in turn regulates cardiac contractions. ACTA1, AKT1, BDK, BDKRB2, CALM1, CALM2, CALM3, CAV1, CHRM1, CHRNA1, FLT1, FLT4, HSPCA, KDR, NOS3, PDE2A, PDE3A, PDE3B, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKG1, PRKG2, RYR2, SLC7A1, SYT1, TNNI1, VEGF 28 ACTA1(4), AKT1(4), BDKRB2(9), CALM1(1), CALM2(1), CAV1(1), CHRM1(5), CHRNA1(7), FLT1(38), FLT4(30), KDR(55), NOS3(19), PDE2A(16), PDE3A(29), PDE3B(6), PRKACB(4), PRKACG(11), PRKAR1A(3), PRKAR1B(4), PRKAR2A(1), PRKAR2B(5), PRKG1(14), PRKG2(16), RYR2(99), SLC7A1(6), SYT1(23), TNNI1(1) 16577975 412 160 390 221 276 33 11 42 49 1 0.104 1.000 1.000 129 GAMMA_HEXACHLOROCYCLOHEXANE_DEGRADATION ACP1, ACP2, ACP5, ACPP, ACPT, ALPI, ALPL, ALPP, ALPP, ALPPL2, ALPPL2, CYP19A1, CYP1A1, CYP1A2, CYP2A6, CYP2A6, CYP2A7, CYP2A7P1, CYP2A13, CYP2B6, CYP2C18, CYP2C19, CYP2C19, CYP2C9, CYP2C8, CYP2C9, CYP2D6, CYP2E1, CYP2F1, CYP2J2, CYP3A4, CYP3A5, CYP3A7, CYP4B1, CYP4F8, CYP51A1, PON1 31 ACP1(4), ACP2(2), ACP5(3), ACPP(9), ACPT(3), ALPI(9), ALPL(11), ALPP(10), ALPPL2(12), CYP19A1(15), CYP1A1(9), CYP1A2(8), CYP2A13(12), CYP2A6(9), CYP2A7(10), CYP2B6(21), CYP2C19(75), CYP2C8(32), CYP2C9(38), CYP2D6(3), CYP2E1(13), CYP2F1(12), CYP2J2(7), CYP3A4(20), CYP3A7(30), CYP4B1(24), CYP4F8(18), CYP51A1(1), PON1(21) 11891676 441 159 408 252 332 24 10 15 59 1 0.00233 1.000 1.000 130 HSA00590_ARACHIDONIC_ACID_METABOLISM Genes involved in arachidonic acid metabolism AKR1C3, ALOX12, ALOX12B, ALOX15, ALOX15B, ALOX5, CBR1, CBR3, CYP2B6, CYP2C18, CYP2C19, CYP2C8, CYP2C9, CYP2E1, CYP2J2, CYP2U1, CYP4A11, CYP4A22, CYP4F2, CYP4F3, DHRS4, EPHX2, GGT1, GGTL3, GGTL4, GPX1, GPX2, GPX3, GPX4, GPX5, GPX6, GPX7, LTA4H, LTC4S, PGDS, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PTGDS, PTGES, PTGES2, PTGIS, PTGS1, PTGS2, TBXAS1 51 AKR1C3(14), ALOX12(6), ALOX12B(15), ALOX15(10), ALOX15B(8), ALOX5(12), CBR3(1), CYP2B6(21), CYP2C19(75), CYP2C8(32), CYP2C9(38), CYP2E1(13), CYP2J2(7), CYP2U1(2), CYP4A11(27), CYP4A22(23), CYP4F2(16), CYP4F3(24), DHRS4(2), EPHX2(5), GGT1(8), GPX1(3), GPX3(4), GPX5(17), GPX6(16), LTA4H(5), PLA2G12B(4), PLA2G1B(1), PLA2G2A(2), PLA2G2D(5), PLA2G2E(5), PLA2G2F(6), PLA2G3(17), PLA2G4A(15), PLA2G5(2), PLA2G6(12), PTGDS(3), PTGES(1), PTGES2(1), PTGIS(17), PTGS1(20), PTGS2(13), TBXAS1(16) 15782064 544 158 510 315 395 36 10 33 67 3 0.00944 1.000 1.000 131 SIG_PIP3_SIGNALING_IN_CARDIAC_MYOCTES Genes related to PIP3 signaling in cardiac myocytes AKT1, AKT2, AKT3, BAD, BCL2L1, CDC42, CDK2, CDKN1B, CDKN2A, CREB1, CREB3, CREB5, EBP, ERBB4, F2RL2, FOXO3A, FRAP1, GAB1, GADD45A, GRB2, GSK3A, GSK3B, IFI27, IGF1, IGFBP1, INPPL1, IRS1, IRS2, IRS4, MET, MYC, NOLC1, P101-PI3K, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PARD3, PARD6A, PDK1, PIK3CA, PIK3CD, PPP1R13B, PREX1, PSCD3, PTEN, PTK2, PTPN1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SFN, SHC1, SLC2A4, SOS1, SOS2, TSC1, TSC2, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ 61 AKT1(4), AKT2(8), AKT3(3), CDC42(2), CDKN1B(1), CREB3(1), CREB5(9), ERBB4(54), F2RL2(8), GAB1(8), GRB2(2), GSK3A(1), GSK3B(3), IFI27(2), IGF1(10), IGFBP1(4), INPPL1(16), IRS1(5), IRS2(3), IRS4(13), MET(23), MYC(5), NOLC1(5), PAK1(4), PAK2(7), PAK3(10), PAK4(8), PAK6(6), PAK7(55), PARD3(18), PARD6A(1), PDK1(2), PIK3CA(10), PIK3CD(8), PPP1R13B(9), PREX1(9), PTK2(7), PTPN1(4), RPS6KA1(8), RPS6KA2(6), RPS6KA3(1), RPS6KB1(3), SHC1(2), SLC2A4(9), SOS1(10), SOS2(13), TSC1(9), TSC2(12), YWHAB(1), YWHAE(2), YWHAG(2), YWHAQ(3) 30968774 429 158 412 215 259 41 22 53 53 1 0.283 1.000 1.000 132 SIG_BCR_SIGNALING_PATHWAY Members of the BCR signaling pathway AKT1, AKT2, AKT3, BAD, BCL2, BCR, BLNK, BTK, CD19, CD22, CD81, CR2, CSK, DAG1, FLOT1, FLOT2, GRB2, GSK3A, GSK3B, INPP5D, ITPR1, ITPR2, ITPR3, LYN, MAP4K1, MAPK1, MAPK3, NFATC1, NFATC2, NR0B2, PDK1, PIK3CA, PIK3CD, PIK3R1, PLCG2, PPP1R13B, PPP3CA, PPP3CB, PPP3CC, PTPRC, RAF1, SHC1, SOS1, SOS2, SYK, VAV1 46 AKT1(4), AKT2(8), AKT3(3), BCL2(2), BCR(15), BLNK(15), BTK(16), CD19(8), CD22(23), CD81(2), CR2(34), CSK(1), DAG1(9), FLOT1(2), GRB2(2), GSK3A(1), GSK3B(3), INPP5D(37), ITPR1(36), ITPR2(20), ITPR3(11), LYN(10), MAP4K1(11), MAPK1(4), MAPK3(4), NFATC1(16), NFATC2(11), NR0B2(6), PDK1(2), PIK3CA(10), PIK3CD(8), PIK3R1(2), PLCG2(27), PPP1R13B(9), PPP3CA(5), PPP3CB(3), PPP3CC(2), PTPRC(35), RAF1(10), SHC1(2), SOS1(10), SOS2(13), SYK(14), VAV1(19) 30119884 485 157 463 225 311 34 29 44 65 2 0.00488 1.000 1.000 133 HSA04340_HEDGEHOG_SIGNALING_PATHWAY Genes involved in Hedgehog signaling pathway BMP2, BMP4, BMP5, BMP6, BMP7, BMP8A, BMP8B, BTRC, CSNK1A1, CSNK1A1L, CSNK1D, CSNK1E, CSNK1G1, CSNK1G2, CSNK1G3, DHH, FBXW11, GAS1, GLI1, GLI2, GLI3, GSK3B, HHIP, IHH, LRP2, PRKACA, PRKACB, PRKACG, PRKX, PRKY, PTCH1, PTCH2, RAB23, SHH, SMO, STK36, SUFU, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT3A, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B, WNT8A, WNT8B, WNT9A, WNT9B, ZIC2 55 BMP2(7), BMP4(4), BMP5(32), BMP6(12), BMP7(5), BMP8A(2), BTRC(4), CSNK1A1(3), CSNK1A1L(7), CSNK1D(3), CSNK1E(5), CSNK1G1(5), CSNK1G2(3), CSNK1G3(3), DHH(2), FBXW11(6), GLI1(17), GLI2(42), GLI3(18), GSK3B(3), HHIP(25), IHH(3), LRP2(100), PRKACA(3), PRKACB(4), PRKACG(11), PRKX(3), PTCH1(7), PTCH2(17), RAB23(1), SHH(3), SMO(10), STK36(16), SUFU(2), WNT1(2), WNT10A(7), WNT10B(6), WNT11(4), WNT16(3), WNT2(8), WNT2B(5), WNT3(5), WNT3A(9), WNT4(1), WNT5A(5), WNT5B(4), WNT6(3), WNT7A(14), WNT7B(6), WNT8A(7), WNT8B(7), WNT9A(3), WNT9B(6), ZIC2(3) 24622933 496 156 466 229 339 44 18 44 51 0 0.00196 1.000 1.000 134 HSA00071_FATTY_ACID_METABOLISM Genes involved in fatty acid metabolism ACAA1, ACAA2, ACADL, ACADM, ACADS, ACADSB, ACADVL, ACAT1, ACAT2, ACOX1, ACOX3, ACSL1, ACSL3, ACSL4, ACSL5, ACSL6, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, CPT1A, CPT1B, CPT1C, CPT2, CYP4A11, CYP4A22, DCI, ECHS1, EHHADH, GCDH, HADH, HADHA, HADHB, HSD17B10, HSD17B4, PECI 47 ACAA1(6), ACAA2(1), ACADL(5), ACADM(4), ACADS(5), ACADSB(5), ACADVL(1), ACAT2(1), ACOX1(8), ACOX3(13), ACSL1(8), ACSL3(8), ACSL4(5), ACSL5(27), ACSL6(12), ADH1A(17), ADH1B(30), ADH1C(1), ADH4(10), ADH5(3), ADH6(14), ADH7(16), ADHFE1(6), ALDH1A3(2), ALDH1B1(11), ALDH2(7), ALDH3A1(8), ALDH3A2(3), ALDH7A1(9), ALDH9A1(2), CPT1A(14), CPT1B(8), CPT1C(17), CPT2(1), CYP4A11(27), CYP4A22(23), ECHS1(3), EHHADH(6), GCDH(6), HADH(2), HADHA(6), HADHB(5), HSD17B10(2), HSD17B4(6) 20055603 374 155 345 158 265 25 21 24 38 1 0.000389 1.000 1.000 135 HSA05130_PATHOGENIC_ESCHERICHIA_COLI_INFECTION_EHEC Genes involved in pathogenic Escherichia coli infection - EHEC ABL1, ACTB, ACTG1, ARHGEF2, ARPC5, ARPC5L, CD14, CDC42, CDH1, CLDN1, CTNNB1, CTTN, EZR, FYN, HCLS1, ITGB1, KRT18, LOC643224, LOC654264, LY96, NCK1, NCK2, NCL, OCLN, PRKCA, RHOA, ROCK1, ROCK2, TLR4, TLR5, TUBA1A, TUBA1B, TUBA1C, TUBA3C, TUBA3D, TUBA3E, TUBA4A, TUBA8, TUBAL3, TUBB, TUBB1, TUBB2A, TUBB2B, TUBB2C, TUBB3, TUBB4, TUBB4Q, TUBB6, TUBB8, WAS, WASL, YWHAQ, YWHAZ 51 ABL1(13), ACTB(8), ACTG1(6), ARHGEF2(19), ARPC5(1), CD14(5), CDC42(2), CDH1(5), CLDN1(5), CTNNB1(14), CTTN(4), EZR(5), FYN(7), HCLS1(13), ITGB1(4), KRT18(4), LY96(4), NCK1(2), NCK2(4), NCL(6), OCLN(7), PRKCA(8), RHOA(2), ROCK1(7), ROCK2(11), TLR4(41), TLR5(22), TUBA1A(4), TUBA1B(4), TUBA1C(1), TUBA3C(23), TUBA3D(13), TUBA3E(4), TUBA4A(7), TUBA8(5), TUBAL3(11), TUBB(1), TUBB1(4), TUBB2A(2), TUBB3(4), TUBB6(10), TUBB8(12), WAS(8), WASL(5), YWHAQ(3) 21401349 350 155 331 147 225 34 13 40 38 0 0.000558 1.000 1.000 136 HSA05131_PATHOGENIC_ESCHERICHIA_COLI_INFECTION_EPEC Genes involved in pathogenic Escherichia coli infection - EPEC ABL1, ACTB, ACTG1, ARHGEF2, ARPC5, ARPC5L, CD14, CDC42, CDH1, CLDN1, CTNNB1, CTTN, EZR, FYN, HCLS1, ITGB1, KRT18, LOC643224, LOC654264, LY96, NCK1, NCK2, NCL, OCLN, PRKCA, RHOA, ROCK1, ROCK2, TLR4, TLR5, TUBA1A, TUBA1B, TUBA1C, TUBA3C, TUBA3D, TUBA3E, TUBA4A, TUBA8, TUBAL3, TUBB, TUBB1, TUBB2A, TUBB2B, TUBB2C, TUBB3, TUBB4, TUBB4Q, TUBB6, TUBB8, WAS, WASL, YWHAQ, YWHAZ 51 ABL1(13), ACTB(8), ACTG1(6), ARHGEF2(19), ARPC5(1), CD14(5), CDC42(2), CDH1(5), CLDN1(5), CTNNB1(14), CTTN(4), EZR(5), FYN(7), HCLS1(13), ITGB1(4), KRT18(4), LY96(4), NCK1(2), NCK2(4), NCL(6), OCLN(7), PRKCA(8), RHOA(2), ROCK1(7), ROCK2(11), TLR4(41), TLR5(22), TUBA1A(4), TUBA1B(4), TUBA1C(1), TUBA3C(23), TUBA3D(13), TUBA3E(4), TUBA4A(7), TUBA8(5), TUBAL3(11), TUBB(1), TUBB1(4), TUBB2A(2), TUBB3(4), TUBB6(10), TUBB8(12), WAS(8), WASL(5), YWHAQ(3) 21401349 350 155 331 147 225 34 13 40 38 0 0.000558 1.000 1.000 137 SIG_REGULATION_OF_THE_ACTIN_CYTOSKELETON_BY_RHO_GTPASES Genes related to regulation of the actin cytoskeleton ACTG1, ACTG2, ACTR2, ACTR3, AKT1, ANGPTL2, CDC42, CFL1, CFL2, FLNA, FLNC, FSCN1, FSCN2, FSCN3, GDI1, GDI2, LIMK1, MYH2, MYLK, MYLK2, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PFN1, PFN2, RHO, ROCK1, ROCK2, RPS4X, VASP, WASF1, WASL 35 ACTG1(6), ACTG2(6), ACTR2(3), ACTR3(2), AKT1(4), ANGPTL2(2), CDC42(2), CFL1(2), FLNA(21), FLNC(65), FSCN1(4), FSCN2(2), FSCN3(12), GDI1(2), GDI2(2), LIMK1(5), MYH2(97), MYLK(46), MYLK2(12), PAK1(4), PAK2(7), PAK3(10), PAK4(8), PAK6(6), PAK7(55), RHO(2), ROCK1(7), ROCK2(11), VASP(3), WASF1(4), WASL(5) 19471038 417 155 381 220 290 45 12 33 37 0 0.0124 1.000 1.000 138 HSA00350_TYROSINE_METABOLISM Genes involved in tyrosine metabolism ABP1, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, AOX1, ARD1A, CARM1, COMT, DBH, DCT, DDC, ECH1, ESCO1, ESCO2, FAH, GOT1, GOT2, GSTZ1, HEMK1, HGD, HPD, LCMT1, LCMT2, LYCAT, MAOA, MAOB, METTL2B, METTL6, MIF, MYST3, MYST4, NAT5, NAT6, PNMT, PNPLA3, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, SH3GLB1, TAT, TH, TPO, TYR, TYRP1, WBSCR22 56 ABP1(22), ADH1A(17), ADH1B(30), ADH1C(1), ADH4(10), ADH5(3), ADH6(14), ADH7(16), ADHFE1(6), ALDH1A3(2), ALDH3A1(8), ALDH3B1(3), ALDH3B2(8), AOC2(9), AOC3(10), AOX1(26), CARM1(4), COMT(3), DBH(15), DCT(4), DDC(14), ESCO1(2), ESCO2(4), FAH(4), GOT1(6), GOT2(6), GSTZ1(1), HEMK1(4), HGD(13), HPD(7), LCMT1(4), LCMT2(1), MAOA(4), MAOB(13), METTL2B(7), METTL6(1), PNMT(4), PNPLA3(3), PRMT2(2), PRMT3(5), PRMT5(7), PRMT7(3), PRMT8(11), SH3GLB1(2), TAT(19), TH(12), TPO(47), TYR(9), TYRP1(10), WBSCR22(1) 24223403 437 154 410 218 308 32 24 33 40 0 0.0385 1.000 1.000 139 HSA04330_NOTCH_SIGNALING_PATHWAY Genes involved in Notch signaling pathway ADAM17, APH1A, CIR, CREBBP, CTBP1, CTBP2, DLL1, DLL3, DLL4, DTX1, DTX2, DTX3, DTX3L, DTX4, DVL1, DVL2, DVL3, EP300, GCN5L2, HDAC1, HDAC2, HES1, JAG1, JAG2, LFNG, LOC652788, MAML1, MAML2, MAML3, MFNG, NCOR2, NCSTN, NOTCH1, NOTCH2, NOTCH3, NOTCH4, NUMB, NUMBL, PCAF, PSEN1, PSEN2, PSENEN, PTCRA, RBPJ, RBPJL, RFNG, SNW1 43 ADAM17(1), APH1A(3), CREBBP(24), CTBP2(1), DLL1(2), DLL3(7), DLL4(8), DTX1(7), DTX2(3), DTX3(4), DTX3L(6), DTX4(4), DVL2(3), DVL3(8), EP300(18), HDAC1(2), HDAC2(2), HES1(2), JAG1(9), JAG2(7), LFNG(3), MAML1(9), MAML2(7), MAML3(9), MFNG(9), NCOR2(26), NCSTN(5), NOTCH1(9), NOTCH2(33), NOTCH3(26), NOTCH4(62), NUMB(4), NUMBL(4), PSEN1(1), PSEN2(2), PTCRA(3), RBPJ(6), RBPJL(4), SNW1(2) 28037603 345 153 342 178 206 32 11 59 36 1 0.578 1.000 1.000 140 SIG_CHEMOTAXIS Genes related to chemotaxis ACTR2, ACTR3, AKT1, AKT2, AKT3, ANGPTL2, ARHGAP1, ARHGAP4, ARHGEF11, BTK, CDC42, CFL1, CFL2, GDI1, GDI2, INPPL1, ITPR1, ITPR2, ITPR3, LIMK1, MYLK, MYLK2, P101-PI3K, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PDK1, PIK3CA, PIK3CD, PIK3CG, PIK3R1, PITX2, PPP1R13B, PTEN, RACGAP1, RHO, ROCK1, ROCK2, RPS4X, SAG, WASF1, WASL 43 ACTR2(3), ACTR3(2), AKT1(4), AKT2(8), AKT3(3), ANGPTL2(2), ARHGAP1(3), ARHGAP4(4), ARHGEF11(20), BTK(16), CDC42(2), CFL1(2), GDI1(2), GDI2(2), INPPL1(16), ITPR1(36), ITPR2(20), ITPR3(11), LIMK1(5), MYLK(46), MYLK2(12), PAK1(4), PAK2(7), PAK3(10), PAK4(8), PAK6(6), PAK7(55), PDK1(2), PIK3CA(10), PIK3CD(8), PIK3CG(27), PIK3R1(2), PITX2(5), PPP1R13B(9), RACGAP1(4), RHO(2), ROCK1(7), ROCK2(11), SAG(11), WASF1(4), WASL(5) 28185869 416 151 392 196 277 33 18 48 39 1 0.00783 1.000 1.000 141 ST_MYOCYTE_AD_PATHWAY Cardiac myocytes have a variety of adrenergic receptors that induce subtype-specific signaling effects. ADRB1, AKT1, APC, ASAH1, BF, CAMP, CAV3, DAG1, DLG4, EPHB2, GAS, GNAI1, GNAQ, HTATIP, ITPR1, ITPR2, ITPR3, KCNJ3, KCNJ5, KCNJ9, MAPK1, PITX2, PLB, PTX1, PTX3, RAC1, RHO, RYR1 22 ADRB1(5), AKT1(4), APC(25), CAMP(2), CAV3(2), DAG1(9), DLG4(6), EPHB2(34), GNAI1(2), GNAQ(6), ITPR1(36), ITPR2(20), ITPR3(11), KCNJ3(20), KCNJ5(13), KCNJ9(6), MAPK1(4), PITX2(5), PTX3(1), RHO(2), RYR1(109) 18403196 322 150 310 197 215 30 17 24 36 0 0.281 1.000 1.000 142 HSA00860_PORPHYRIN_AND_CHLOROPHYLL_METABOLISM Genes involved in porphyrin and chlorophyll metabolism ALAD, ALAS1, ALAS2, BLVRA, BLVRB, COX10, COX15, CP, CPOX, EARS2, EPRS, FECH, FTH1, FTMT, GUSB, HCCS, HMBS, HMOX1, HMOX2, MMAB, PPOX, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, UROD, UROS 40 ALAD(5), ALAS1(2), ALAS2(5), BLVRA(2), BLVRB(1), COX10(6), COX15(3), CP(12), CPOX(4), EARS2(2), EPRS(13), FECH(3), FTH1(3), FTMT(6), GUSB(5), HCCS(2), HMBS(1), HMOX1(1), HMOX2(1), MMAB(2), PPOX(4), UGT1A1(77), UGT2A3(28), UGT2B10(45), UGT2B11(23), UGT2B15(31), UGT2B17(29), UGT2B28(26), UGT2B4(34), UGT2B7(19), UROS(1) 16769645 396 149 361 141 280 30 13 21 51 1 1.15e-06 1.000 1.000 143 HSA04115_P53_SIGNALING_PATHWAY Genes involved in p53 signaling pathway APAF1, ATM, ATR, BAI1, BAX, BBC3, BID, CASP3, CASP8, CASP9, CCNB1, CCNB2, CCNB3, CCND1, CCND2, CCND3, CCNE1, CCNE2, CCNG1, CCNG2, CD82, CDC2, CDK2, CDK4, CDK6, CDKN1A, CDKN2A, CHEK1, CHEK2, CYCS, DDB2, EI24, FAS, GADD45A, GADD45B, GADD45G, GTSE1, IGF1, IGFBP3, LRDD, MDM2, MDM4, P53AIP1, PERP, PMAIP1, PPM1D, PTEN, RCHY1, RFWD2, RPRM, RRM2, RRM2B, SCOTIN, SERPINB5, SERPINE1, SESN1, SESN2, SESN3, SFN, SIAH1, STEAP3, THBS1, TNFRSF10B, TP53, TP53I3, TP73, TSC2, ZMAT3 61 APAF1(6), ATM(15), ATR(23), BAI1(16), BAX(3), CASP3(2), CASP8(9), CASP9(2), CCNB2(2), CCNB3(31), CCND1(2), CCND2(6), CCND3(2), CCNE1(4), CCNE2(8), CCNG1(2), CCNG2(1), CDK4(7), CDK6(2), CDKN1A(3), CHEK1(2), CHEK2(2), CYCS(1), DDB2(3), EI24(3), FAS(6), GADD45B(2), GTSE1(9), IGF1(10), IGFBP3(2), MDM2(1), MDM4(2), PERP(2), PPM1D(4), RFWD2(6), RPRM(3), RRM2(3), RRM2B(2), SERPINB5(8), SERPINE1(5), SESN1(2), SESN2(6), SESN3(1), STEAP3(8), THBS1(30), TNFRSF10B(4), TP53I3(2), TP73(6), TSC2(12), ZMAT3(1) 25560875 294 149 284 151 190 21 14 35 33 1 0.409 1.000 1.000 144 SIG_PIP3_SIGNALING_IN_B_LYMPHOCYTES Genes related to PIP3 signaling in B lymphocytes AKT1, AKT2, AKT3, BCR, BTK, CD19, CDKN2A, DAPP1, FLOT1, FLOT2, FOXO3A, GAB1, ITPR1, ITPR2, ITPR3, LYN, NR0B2, P101-PI3K, PDK1, PHF11, PIK3CA, PITX2, PLCG2, PPP1R13B, PREX1, PSCD3, PTEN, PTPRC, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SAG, SYK, TEC, VAV1 31 AKT1(4), AKT2(8), AKT3(3), BCR(15), BTK(16), CD19(8), DAPP1(6), FLOT1(2), GAB1(8), ITPR1(36), ITPR2(20), ITPR3(11), LYN(10), NR0B2(6), PDK1(2), PHF11(1), PIK3CA(10), PITX2(5), PLCG2(27), PPP1R13B(9), PREX1(9), PTPRC(35), RPS6KA1(8), RPS6KA2(6), RPS6KA3(1), RPS6KB1(3), SAG(11), SYK(14), TEC(13), VAV1(19) 21858655 326 149 307 179 212 24 19 30 41 0 0.143 1.000 1.000 145 G1_TO_S_CELL_CYCLE_REACTOME ATM, CCNA1, CCNB1, CCND1, CCND2, CCND3, CCNE1, CCNE2, CCNG2, CCNH, CDC25A, CDC45L, CDK2, CDK4, CDK7, CDKN1A, CDKN1B, CDKN1C, CDKN2A, CDKN2B, CDKN2C, CDKN2D, CREB3, CREB3L1, CREB3L3, CREB3L4, CREBL1, CREBL1, TNXB, E2F1, E2F2, E2F3, E2F4, E2F5, E2F6, FLJ14001, GADD45A, GBA2, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, MDM2, MNAT1, MYC, MYT1, NACA, NACA, FKSG17, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, POLA2, POLE, POLE2, PRIM1, PRIM2A, RB1, RBL1, RPA1, RPA2, RPA3, TFDP1, TFDP2, TP53, WEE1 63 ATM(15), CCNA1(14), CCND1(2), CCND2(6), CCND3(2), CCNE1(4), CCNE2(8), CCNG2(1), CCNH(2), CDC25A(8), CDK4(7), CDK7(2), CDKN1A(3), CDKN1B(1), CDKN2C(1), CREB3(1), CREB3L1(5), CREB3L3(10), CREB3L4(7), E2F1(5), E2F2(5), E2F3(5), E2F4(3), E2F5(3), E2F6(1), GBA2(2), MCM2(11), MCM3(9), MCM4(8), MCM5(5), MCM6(5), MCM7(1), MDM2(1), MNAT1(2), MYC(5), MYT1(21), PCNA(2), POLA2(8), POLE(16), POLE2(2), PRIM1(2), RB1(10), RBL1(12), RPA1(3), RPA2(1), TFDP1(2), TFDP2(4), TNXB(128), WEE1(2) 31546339 383 148 368 173 241 33 15 51 41 2 0.0470 1.000 1.000 146 ST_FAS_SIGNALING_PATHWAY The Fas receptor induces apoptosis and NF-kB activation when bound to Fas ligand. ADPRT, ALG2, BAK1, BAX, BFAR, BIRC4, BTK, CAD, CASP10, CASP3, CASP8, CASP8AP2, CD7, CDK2AP1, CSNK1A1, DAXX, DEDD, DEDD2, DFFA, DIABLO, EGFR, EPHB2, FADD, FAF1, FAIM2, FREQ, HRB, HSPB1, IL1A, IL8, MAP2K4, MAP2K7, MAP3K1, MAP3K5, MAPK1, MAPK10, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MCP, MET, NFAT5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, NR0B2, PFN1, PFN2, PTPN13, RALBP1, RIPK1, ROCK1, SMPD1, TNFRSF6, TNFRSF6B, TP53, TPX2, TRAF2, TUFM, VIL2 58 ALG2(5), BAK1(1), BAX(3), BFAR(1), BTK(16), CAD(18), CASP10(6), CASP3(2), CASP8(9), CASP8AP2(10), CD7(1), CDK2AP1(2), CSNK1A1(3), DAXX(9), DEDD(1), DEDD2(3), DFFA(2), DIABLO(2), EGFR(25), EPHB2(34), FAF1(8), FAIM2(5), HSPB1(2), IL1A(5), IL8(1), MAP2K4(4), MAP2K7(5), MAP3K1(4), MAP3K5(23), MAPK1(4), MAPK10(9), MAPK8(1), MAPK8IP1(7), MAPK8IP2(7), MAPK8IP3(10), MAPK9(3), MET(23), NFAT5(8), NFKB1(6), NFKB2(3), NFKBIA(2), NFKBIB(1), NFKBIL1(3), NR0B2(6), PTPN13(15), RALBP1(3), RIPK1(3), ROCK1(7), SMPD1(2), TNFRSF6B(4), TPX2(11), TRAF2(2), TUFM(7) 29237951 357 147 346 192 215 29 18 43 52 0 0.601 1.000 1.000 147 ST_T_CELL_SIGNAL_TRANSDUCTION On activation of the T cell receptor, phospholipase C is activated to produce second messengers DAG and PIP3, both required for T cell activation. CBL, CD28, CD3D, CSK, CTLA4, DAG1, DTYMK, EPHB2, FBXW7, GRAP2, GRB2, ITK, ITPKA, ITPKB, LAT, LCK, LCP2, MAPK1, NCK1, NFAT5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PAG, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PLCG1, PTPRC, RAF1, RASGRP1, RASGRP2, RASGRP3, RASGRP4, SOS1, SOS2, VAV1, ZAP70 44 CBL(10), CD28(2), CD3D(7), CSK(1), CTLA4(2), DAG1(9), EPHB2(34), FBXW7(11), GRAP2(5), GRB2(2), ITK(24), ITPKB(11), LAT(2), LCK(15), LCP2(9), MAPK1(4), NCK1(2), NFAT5(8), NFKB1(6), NFKB2(3), NFKBIA(2), NFKBIB(1), NFKBIL1(3), PAK1(4), PAK2(7), PAK3(10), PAK4(8), PAK6(6), PAK7(55), PLCG1(8), PTPRC(35), RAF1(10), RASGRP1(11), RASGRP2(7), RASGRP3(12), RASGRP4(11), SOS1(10), SOS2(13), VAV1(19), ZAP70(7) 22609388 406 147 386 190 257 31 18 45 55 0 0.0601 1.000 1.000 148 BLOOD_CLOTTING_CASCADE F10, F11, F12, F13B, F2, F5, F7, F8, F8A1, F9, FGA, FGB, FGG, LPA, PLG, PLAT, PLAU, PLG, SERPINB2, SERPINE1, SERPINF2, VWF 20 F10(7), F11(12), F12(1), F13B(32), F2(11), F5(36), F7(7), F8(49), F9(15), FGA(41), FGB(10), FGG(10), LPA(55), PLAT(4), PLAU(3), PLG(34), SERPINB2(36), SERPINE1(5), SERPINF2(7), VWF(56) 14335045 431 146 407 170 304 29 22 34 42 0 0.00330 1.000 1.000 149 GLUCONEOGENESIS ACYP1, ACYP2, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AKR1A1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH9A1, ALDOA, ALDOB, ALDOC, BPGM, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, GAPDH, GCK, GPI, HK1, HK2, HK3, LDHA, LDHB, LDHC, PDHA1, PDHA2, PDHB, PFKM, PFKP, PGAM1, PGK1, PGM1, PGM3, PKLR, PKM2, TPI1 53 ACYP1(1), ADH1A(17), ADH1B(30), ADH1C(1), ADH4(10), ADH6(14), ADH7(16), ADHFE1(6), AKR1A1(3), ALDH1A1(5), ALDH1A2(14), ALDH1A3(2), ALDH1B1(11), ALDH2(7), ALDH3A1(8), ALDH3A2(3), ALDH3B1(3), ALDH3B2(8), ALDH9A1(2), ALDOA(2), ALDOB(14), ALDOC(4), BPGM(3), DLAT(4), DLD(3), ENO1(4), ENO2(5), ENO3(3), FBP1(3), FBP2(2), G6PC(5), GAPDH(2), GCK(17), GPI(3), HK1(3), HK2(13), HK3(14), LDHA(4), LDHB(2), LDHC(5), PDHA1(4), PDHA2(20), PDHB(1), PFKM(2), PFKP(2), PGK1(2), PGM1(6), PGM3(1), PKLR(13), PKM2(7), TPI1(1) 19933565 335 146 307 143 225 27 19 30 34 0 4.86e-05 1.000 1.000 150 GLYCOLYSIS ACYP1, ACYP2, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AKR1A1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH9A1, ALDOA, ALDOB, ALDOC, BPGM, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, GAPDH, GCK, GPI, HK1, HK2, HK3, LDHA, LDHB, LDHC, PDHA1, PDHA2, PDHB, PFKM, PFKP, PGAM1, PGK1, PGM1, PGM3, PKLR, PKM2, TPI1 53 ACYP1(1), ADH1A(17), ADH1B(30), ADH1C(1), ADH4(10), ADH6(14), ADH7(16), ADHFE1(6), AKR1A1(3), ALDH1A1(5), ALDH1A2(14), ALDH1A3(2), ALDH1B1(11), ALDH2(7), ALDH3A1(8), ALDH3A2(3), ALDH3B1(3), ALDH3B2(8), ALDH9A1(2), ALDOA(2), ALDOB(14), ALDOC(4), BPGM(3), DLAT(4), DLD(3), ENO1(4), ENO2(5), ENO3(3), FBP1(3), FBP2(2), G6PC(5), GAPDH(2), GCK(17), GPI(3), HK1(3), HK2(13), HK3(14), LDHA(4), LDHB(2), LDHC(5), PDHA1(4), PDHA2(20), PDHB(1), PFKM(2), PFKP(2), PGK1(2), PGM1(6), PGM3(1), PKLR(13), PKM2(7), TPI1(1) 19933565 335 146 307 143 225 27 19 30 34 0 4.86e-05 1.000 1.000 151 HSA00240_PYRIMIDINE_METABOLISM Genes involved in pyrimidine metabolism AICDA, AK3, CAD, CANT1, CDA, CMPK, CTPS, CTPS2, DCK, DCTD, DHODH, DPYD, DPYS, DTYMK, DUT, ECGF1, ENTPD1, ENTPD3, ENTPD4, ENTPD5, ENTPD6, ENTPD8, ITPA, NME1, NME2, NME4, NME6, NME7, NP, NT5C, NT5C1A, NT5C1B, NT5C2, NT5C3, NT5E, NT5M, NUDT2, PNPT1, POLA1, POLA2, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, POLE3, POLE4, POLR1A, POLR1B, POLR1C, POLR1D, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLR3A, POLR3B, POLR3G, POLR3GL, POLR3H, POLR3K, PRIM1, PRIM2, RFC5, RRM1, RRM2, RRM2B, TK1, TK2, TXNRD1, TXNRD2, TYMS, UCK1, UCK2, UMPS, UPB1, UPP1, UPP2, UPRT, ZNRD1 85 AICDA(9), CAD(18), CANT1(10), CDA(3), CTPS2(5), DCTD(3), DHODH(5), DPYD(67), DPYS(24), ENTPD1(12), ENTPD3(9), ENTPD4(4), ENTPD5(2), ENTPD6(4), ENTPD8(2), ITPA(1), NME4(1), NME6(3), NME7(4), NT5C1A(6), NT5C2(3), NT5C3(2), NT5E(6), NT5M(2), NUDT2(1), PNPT1(3), POLA1(3), POLA2(8), POLD1(7), POLD2(2), POLD3(7), POLE(16), POLE2(2), POLR1A(13), POLR1B(9), POLR1C(1), POLR2A(13), POLR2B(12), POLR2C(1), POLR2D(1), POLR2E(3), POLR2F(1), POLR2H(2), POLR2J(1), POLR3A(7), POLR3B(14), POLR3G(1), POLR3GL(2), POLR3H(1), POLR3K(1), PRIM1(2), RRM1(3), RRM2(3), RRM2B(2), TK2(1), TXNRD1(5), TXNRD2(3), TYMS(1), UCK1(3), UCK2(1), UMPS(2), UPB1(10), UPP1(1), UPP2(6), UPRT(1) 32679126 381 146 358 192 246 33 14 49 39 0 0.145 1.000 1.000 152 INOSITOL_PHOSPHATE_METABOLISM IMPA1, INPP1, INPP4A, INPP4B, INPP5A, INPPL1, ITPKA, ITPKB, MIOX, OCRL, PIK3C2A, PIK3C2B, PIK3C2G, PIK3CA, PIK3CB, PIK3CG, PIK4CA, PIK4CA, LOC220686, PIP5K2B, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCG1, PLCG2 23 IMPA1(1), INPP1(3), INPP4A(7), INPP4B(2), INPP5A(4), INPPL1(16), ITPKB(11), MIOX(4), OCRL(6), PIK3C2A(8), PIK3C2B(16), PIK3C2G(53), PIK3CA(10), PIK3CB(14), PIK3CG(27), PLCB1(54), PLCB2(12), PLCB3(4), PLCB4(86), PLCD1(4), PLCG1(8), PLCG2(27) 18173275 377 145 339 168 264 16 16 32 47 2 0.00331 1.000 1.000 153 ST_B_CELL_ANTIGEN_RECEPTOR B cell receptors bind antigens and promote B cell activation. AKT1, AKT2, AKT3, BAD, BCR, BLNK, BTK, CD19, CSK, DAG1, EPHB2, GRB2, ITPKA, ITPKB, LYN, MAP2K1, MAP2K2, MAPK1, NFAT5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PAG, PI3, PIK3CA, PIK3CD, PIK3R1, PLCG2, PPP1R13B, RAF1, SERPINA4, SHC1, SOS1, SOS2, SYK, VAV1 39 AKT1(4), AKT2(8), AKT3(3), BCR(15), BLNK(15), BTK(16), CD19(8), CSK(1), DAG1(9), EPHB2(34), GRB2(2), ITPKB(11), LYN(10), MAP2K1(14), MAP2K2(5), MAPK1(4), NFAT5(8), NFKB1(6), NFKB2(3), NFKBIA(2), NFKBIB(1), NFKBIL1(3), PI3(6), PIK3CA(10), PIK3CD(8), PIK3R1(2), PLCG2(27), PPP1R13B(9), RAF1(10), SERPINA4(20), SHC1(2), SOS1(10), SOS2(13), SYK(14), VAV1(19) 21547524 332 145 315 166 208 26 14 39 44 1 0.164 1.000 1.000 154 HSA00564_GLYCEROPHOSPHOLIPID_METABOLISM Genes involved in glycerophospholipid metabolism ACHE, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPAT6, ARD1A, CDIPT, CDS1, CDS2, CHAT, CHKA, CHKB, CHPT1, CRLS1, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKI, DGKQ, DGKZ, ESCO1, ESCO2, ETNK1, ETNK2, GNPAT, GPAM, GPD1, GPD1L, GPD2, LCAT, LYCAT, LYPLA1, LYPLA2, LYPLA3, MYST3, MYST4, NAT5, NAT6, PCYT1A, PCYT1B, PEMT, PHOSPHO1, PISD, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLD1, PLD2, PNPLA3, PPAP2A, PPAP2B, PPAP2C, PTDSS1, PTDSS2, SH3GLB1 63 ACHE(8), AGPAT1(1), AGPAT2(2), AGPAT3(6), AGPAT4(6), AGPAT6(3), CDS1(11), CDS2(5), CHAT(17), CHKA(2), CHKB(3), CHPT1(1), CRLS1(1), DGKA(3), DGKB(27), DGKD(14), DGKE(8), DGKG(18), DGKH(10), DGKI(31), DGKQ(7), DGKZ(6), ESCO1(2), ESCO2(4), ETNK1(5), GNPAT(1), GPAM(7), GPD1(9), GPD1L(2), GPD2(3), LYPLA1(1), LYPLA2(1), PCYT1A(3), PCYT1B(9), PEMT(2), PISD(2), PLA2G12B(4), PLA2G1B(1), PLA2G2A(2), PLA2G2D(5), PLA2G2E(5), PLA2G2F(6), PLA2G3(17), PLA2G4A(15), PLA2G5(2), PLA2G6(12), PLD1(13), PLD2(8), PNPLA3(3), PPAP2A(1), PPAP2B(11), PPAP2C(8), PTDSS2(3), SH3GLB1(2) 26620888 359 144 339 178 228 30 15 34 51 1 0.0996 1.000 1.000 155 HSA00380_TRYPTOPHAN_METABOLISM Genes involved in tryptophan metabolism AADAT, AANAT, ABP1, ACAT1, ACAT2, ACMSD, AFMID, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, AOC2, AOC3, AOX1, ASMT, CARM1, CAT, CYP1A1, CYP1A2, CYP1B1, DDC, ECHS1, EHHADH, GCDH, HAAO, HADH, HADHA, HEMK1, HSD17B10, HSD17B4, INDO, INDOL1, INMT, KMO, KYNU, LCMT1, LCMT2, LNX1, MAOA, MAOB, METTL2B, METTL6, NFX1, OGDH, OGDHL, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, TDO2, TPH1, TPH2, WARS, WARS2, WBSCR22 58 AADAT(5), AANAT(1), ABP1(22), ACAT2(1), ACMSD(13), AFMID(2), ALDH1A3(2), ALDH1B1(11), ALDH2(7), ALDH3A1(8), ALDH3A2(3), ALDH7A1(9), ALDH9A1(2), AOC2(9), AOC3(10), AOX1(26), ASMT(9), CARM1(4), CAT(8), CYP1A1(9), CYP1A2(8), CYP1B1(4), DDC(14), ECHS1(3), EHHADH(6), GCDH(6), HAAO(3), HADH(2), HADHA(6), HEMK1(4), HSD17B10(2), HSD17B4(6), INMT(12), KMO(8), KYNU(14), LCMT1(4), LCMT2(1), LNX1(18), MAOA(4), MAOB(13), METTL2B(7), METTL6(1), NFX1(8), OGDH(8), OGDHL(42), PRMT2(2), PRMT3(5), PRMT5(7), PRMT7(3), PRMT8(11), TDO2(4), TPH1(12), TPH2(13), WARS(5), WARS2(4), WBSCR22(1) 24673764 432 143 414 219 294 33 23 44 37 1 0.0519 1.000 1.000 156 NOS1PATHWAY Glutamate stimulates NMDA-mediates calcium influx, which promotes nitric oxide synthesis from arginine by neuronal nitric oxide synthase, activating guanylate cyclase. CALM1, CALM2, CALM3, DLG4, GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D, NOS1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, SYT1 21 CALM1(1), CALM2(1), DLG4(6), GRIN1(8), GRIN2A(105), GRIN2B(57), GRIN2C(8), GRIN2D(10), NOS1(74), PPP3CA(5), PPP3CB(3), PPP3CC(2), PRKACB(4), PRKACG(11), PRKAR1A(3), PRKAR1B(4), PRKAR2A(1), PRKAR2B(5), PRKCA(8), SYT1(23) 10388910 339 143 315 204 247 31 6 21 33 1 0.164 1.000 1.000 157 ARGININE_AND_PROLINE_METABOLISM ABP1, AGMAT, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH4A1, ALDH9A1, AMD1, AOC2, AOC3, ARG1, ARG2, ASL, ASS, CKB, CKM, CKMT1, CKMT1B, CKMT1A, CKMT2, CPS1, DAO, GAMT, GATM, GLUD1, GOT1, GOT2, MAOA, MAOB, NOS1, NOS2A, NOS3, OAT, ODC1, OTC, P4HA1, P4HA2, P4HA3, P4HB, PYCR1, RARS, SAT, SMS 43 ABP1(22), AGMAT(4), ALDH1A1(5), ALDH1A2(14), ALDH1A3(2), ALDH1B1(11), ALDH2(7), ALDH3A1(8), ALDH3A2(3), ALDH4A1(6), ALDH9A1(2), AOC2(9), AOC3(10), ARG1(2), ARG2(2), ASL(6), CKM(3), CKMT1A(1), CKMT2(5), CPS1(26), DAO(11), GAMT(4), GATM(6), GLUD1(2), GOT1(6), GOT2(6), MAOA(4), MAOB(13), NOS1(74), NOS3(19), OAT(4), ODC1(3), OTC(4), P4HA1(10), P4HA2(6), P4HA3(12), P4HB(4), PYCR1(1), RARS(7), SMS(4) 17964802 348 142 331 186 222 35 19 30 42 0 0.104 1.000 1.000 158 FMLPPATHWAY The fMLP receptor is a G-protein coupled receptor in neutrophils that recognizes formylated bacterial peptides and activates NADPH oxidase. CALM1, CALM2, CALM3, CAMK1, CAMK1G, ELK1, FPR1, GNA15, GNB1, GNGT1, HRAS, MAP2K1, MAP2K2, MAP2K3, MAP2K6, MAP3K1, MAPK1, MAPK14, MAPK3, NCF1, NCF2, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKBIA, PAK1, PIK3C2G, PLCB1, PPP3CA, PPP3CB, PPP3CC, RAC1, RAF1, RELA, SYT1 36 CALM1(1), CALM2(1), CAMK1(5), CAMK1G(11), ELK1(3), FPR1(21), GNA15(6), GNB1(1), HRAS(3), MAP2K1(14), MAP2K2(5), MAP2K3(8), MAP2K6(3), MAP3K1(4), MAPK1(4), MAPK14(5), MAPK3(4), NCF1(3), NCF2(9), NFATC1(16), NFATC2(11), NFATC3(10), NFATC4(17), NFKB1(6), NFKBIA(2), PAK1(4), PIK3C2G(53), PLCB1(54), PPP3CA(5), PPP3CB(3), PPP3CC(2), RAF1(10), RELA(4), SYT1(23) 15354235 331 142 298 135 223 25 14 31 38 0 0.00575 1.000 1.000 159 HSA00040_PENTOSE_AND_GLUCURONATE_INTERCONVERSIONS Genes involved in pentose and glucuronate interconversions AKR1B1, DCXR, GUSB, RPE, UGDH, UGP2, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, XYLB 24 AKR1B1(2), GUSB(5), UGDH(1), UGP2(1), UGT1A1(77), UGT2A3(28), UGT2B10(45), UGT2B11(23), UGT2B15(31), UGT2B17(29), UGT2B28(26), UGT2B4(34), UGT2B7(19), XYLB(6) 10685068 327 142 292 119 238 23 9 15 41 1 1.36e-05 1.000 1.000 160 HSA04612_ANTIGEN_PROCESSING_AND_PRESENTATION Genes involved in antigen processing and presentation B2M, CALR, CANX, CD4, CD74, CD8A, CD8B, CIITA, CREB1, CTSB, CTSL1, CTSS, HLA-A, HLA-A29.1, HLA-B, HLA-C, HLA-DMA, HLA-DMB, HLA-DOA, HLA-DOB, HLA-DPA1, HLA-DPB1, HLA-DQA1, HLA-DQA2, HLA-DQB1, HLA-DQB2, HLA-DRA, HLA-DRB1, HLA-DRB3, HLA-DRB4, HLA-DRB5, HLA-E, HLA-F, HLA-G, HSP90AA1, HSP90AB1, HSPA5, IFI30, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, KIR2DL1, KIR2DL2, KIR2DL3, KIR2DL4, KIR2DL5A, KIR2DS1, KIR2DS2, KIR2DS3, KIR2DS4, KIR2DS5, KIR3DL1, KIR3DL2, KIR3DL3, KLRC1, KLRC2, KLRC3, KLRC4, KLRD1, LGMN, LTA, NFYA, NFYB, NFYC, PDIA3, PSME1, PSME2, RFX5, RFXANK, RFXAP, TAP1, TAP2, TAPBP 73 B2M(4), CALR(2), CANX(1), CD4(8), CD74(7), CD8A(2), CD8B(7), CIITA(18), CTSL1(1), CTSS(7), HLA-A(3), HLA-C(9), HLA-DMA(7), HLA-DMB(7), HLA-DOA(5), HLA-DPA1(2), HLA-DPB1(2), HLA-DQA1(7), HLA-DQA2(7), HLA-DQB1(5), HLA-DRA(12), HLA-DRB5(6), HLA-E(1), HLA-F(4), HLA-G(6), HSP90AA1(3), HSP90AB1(6), HSPA5(6), IFI30(2), IFNA1(1), IFNA10(2), IFNA13(1), IFNA14(8), IFNA16(11), IFNA17(2), IFNA2(1), IFNA21(7), IFNA4(1), IFNA5(4), IFNA6(2), IFNA7(6), IFNA8(3), KIR2DL1(29), KIR3DL2(45), KIR3DL3(6), KLRC1(4), KLRC2(14), KLRC4(6), KLRD1(5), LGMN(6), LTA(4), NFYA(1), NFYB(2), NFYC(2), PDIA3(3), PSME2(4), RFX5(5), RFXANK(1), RFXAP(1), TAP1(2), TAP2(14), TAPBP(2) 18796696 362 142 347 213 241 34 12 35 40 0 0.373 1.000 1.000 161 RIBOSOMAL_PROTEINS ANK2, APG10L, RPS23, B3GALT4, CDR1, DGKI, FAU, IL6ST, KIAA1394, LOC133957, MRPL19, NET_5, PIGK, RPL10, RPL11, RPL12, RPL13, RPL13, LOC388344, RPL13A, RPL13A, LOC283340, LOC387930, RPL14, RPL14, RPL14L, RPL15, RPL15, LOC136321, LOC402694, RPL17, RPL17, dJ612B15.1, RPL18, RPL18A, LOC285053, LOC347544, LOC390354, RPL18A, LOC390354, RPL19, RPL21, RPL21, LOC387753, LOC388143, LOC388532, LOC388621, LOC389156, LOC390488, LOC402336, LOC440487, LOC440575, RPL21, LOC387753, LOC388143, LOC388532, LOC388621, LOC389156, LOC390488, LOC440487, LOC440575, RPL22, RPL23, RPL24, RPL24, SLC36A2, RPL26, LOC391126, LOC392501, LOC400055, LOC441073, LOC441533, RPL27, RPL27A, RPL27A, LOC389435, RPL28, RPL29, RPL29, LOC283412, LOC284064, LOC389655, LOC391738, LOC401911, RPL3, RPL30, RPL31, RPL32, RPL34, LOC342994, RPL35, RPL35A, RPL36, RPL37, RPL38, RPL39, RPL3L, RPL4, RPL41, RPL5, RPL5, LOC388907, RPL5, RNU66, LOC388907, RPL6, RPL7, RPL7, LOC389305, RPL7, LOC90193, LOC388401, LOC389305, LOC392550, LOC439954, RPL7A, RPL7A, LOC133748, LOC388474, RPL7A, RNU36B, LOC133748, LOC388474, RPL8, RPL9, RPLP0, RPLP0, RPLP0_like, RPLP1, RPLP2, RPS10, RPS10, LOC158104, LOC388885, LOC389127, LOC390842, LOC401817, RPS10, LOC388885, RPS11, RPS12, RPS13, RPS14, RPS15, RPS16, RPS16, LOC441876, RPS17, RPS17, LOC402057, RPS18, RPS19, RPS2, RPS2, LOC91561, LOC148430, LOC286444, LOC400963, LOC440589, RPS20, RPS21, RPS23, RPS24, RPS25, RPS26, RPS26L, LOC440440, RPS27, RPS27A, RPS27A, LOC388720, LOC389425, RPS28, RPS29, RPS3, RPS3A, RPS3A, LOC146053, LOC400652, LOC401016, LOC439992, RPS4X, RPS4Y1, RPS5, RPS6, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA6, RPS6KB1, RPS6KB2, RPS7, RPS8, RPS9, RPSA, LOC388524, LOC388654, SCDR10, TBC1D10C, TSPAN9, UBA52, UBB, UBC 92 ANK2(56), B3GALT4(2), CDR1(14), DGKI(31), IL6ST(10), MRPL19(1), PIGK(7), RPL10(3), RPL11(4), RPL12(1), RPL13(1), RPL13A(2), RPL14(1), RPL15(2), RPL18(5), RPL18A(2), RPL19(1), RPL21(1), RPL22(2), RPL26(1), RPL27(3), RPL27A(1), RPL29(1), RPL3(2), RPL30(1), RPL32(1), RPL35(1), RPL35A(1), RPL38(1), RPL39(1), RPL3L(5), RPL4(4), RPL5(7), RPL6(1), RPL7(1), RPLP0(1), RPS11(1), RPS13(1), RPS15(1), RPS16(2), RPS18(2), RPS19(1), RPS2(2), RPS20(2), RPS24(1), RPS26(1), RPS29(1), RPS3A(1), RPS5(1), RPS6(1), RPS6KA1(8), RPS6KA2(6), RPS6KA3(1), RPS6KA6(19), RPS6KB1(3), RPS6KB2(2), RPS7(4), RPS8(1), RPSA(10), SLC36A2(11), TBC1D10C(5), TSPAN9(4), UBC(13) 21117799 284 142 270 155 182 24 16 28 34 0 0.359 1.000 1.000 162 HSA05120_EPITHELIAL_CELL_SIGNALING_IN_HELICOBACTER_PYLORI_INFECTION Genes involved in epithelial cell signaling in Helicobacter pylori infection ADAM10, ADAM17, ATP6AP1, ATP6V0A1, ATP6V0A2, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0D1, ATP6V0D2, ATP6V0E1, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1E2, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, CASP3, CCL5, CDC42, CHUK, CSK, CXCL1, EGFR, F11R, GIT1, HBEGF, IGSF5, IKBKB, IKBKG, IL8, IL8RA, IL8RB, JAM2, JAM3, JUN, LYN, MAP2K4, MAP3K14, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK8, MAPK9, MET, NFKB1, NFKB2, NFKBIA, NOD1, PAK1, PLCG1, PLCG2, PTPN11, PTPRZ1, RAC1, RELA, SRC, TCIRG1, TJP1 64 ADAM10(8), ADAM17(1), ATP6AP1(3), ATP6V0A1(12), ATP6V0A2(5), ATP6V0A4(22), ATP6V0D1(1), ATP6V0D2(10), ATP6V0E1(1), ATP6V1A(2), ATP6V1B1(4), ATP6V1B2(3), ATP6V1C1(1), ATP6V1C2(7), ATP6V1E1(1), ATP6V1E2(3), ATP6V1F(1), ATP6V1G2(1), ATP6V1G3(7), ATP6V1H(5), CASP3(2), CDC42(2), CHUK(2), CSK(1), EGFR(25), F11R(7), GIT1(4), HBEGF(1), IGSF5(11), IKBKB(4), IL8(1), JAM2(11), JAM3(3), JUN(1), LYN(10), MAP2K4(4), MAP3K14(6), MAPK10(9), MAPK11(1), MAPK12(1), MAPK13(5), MAPK14(5), MAPK8(1), MAPK9(3), MET(23), NFKB1(6), NFKB2(3), NFKBIA(2), NOD1(9), PAK1(4), PLCG1(8), PLCG2(27), PTPN11(10), PTPRZ1(26), RELA(4), SRC(2), TCIRG1(5), TJP1(13) 28543801 360 141 352 211 223 30 17 43 47 0 0.753 1.000 1.000 163 GLYCEROPHOSPHOLIPID_METABOLISM ACHE, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPS, CDIPT, CDS1, CDS2, CHAT, CHKA, CHKB, CHKB, CPT1B, CLC, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKQ, DGKZ, ETNK1, GNPAT, GPD1, GPD2, LCAT, LGALS13, LYPLA1, LYPLA2, LYPLA2, LYPLA2P1, LOC388499, LYPLA3, PAFAH1B1, PAFAH2, PCYT1A, PCYT1B, PEMT, PISD, PLA2G1B, PLA2G2A, PLA2G2E, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCB2, PLCG1, PLCG2, PPAP2A, PPAP2B, PPAP2C 49 ACHE(8), AGPAT1(1), AGPAT2(2), AGPAT3(6), AGPAT4(6), AGPS(4), CDS1(11), CDS2(5), CHAT(17), CHKA(2), CHKB(3), CLC(5), CPT1B(8), DGKA(3), DGKB(27), DGKD(14), DGKE(8), DGKG(18), DGKH(10), DGKQ(7), DGKZ(6), ETNK1(5), GNPAT(1), GPD1(9), GPD2(3), LGALS13(4), LYPLA1(1), LYPLA2(1), PAFAH1B1(4), PAFAH2(2), PCYT1A(3), PCYT1B(9), PEMT(2), PISD(2), PLA2G1B(1), PLA2G2A(2), PLA2G2E(5), PLA2G3(17), PLA2G4A(15), PLA2G5(2), PLA2G6(12), PLCB2(12), PLCG1(8), PLCG2(27), PPAP2A(1), PPAP2B(11), PPAP2C(8) 20348553 338 140 323 165 228 24 11 27 47 1 0.00727 1.000 1.000 164 TYROSINE_METABOLISM ABP1, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, AOX1, COMT, DBH, DCT, DDC, FAH, GOT1, GOT2, GSTZ1, HGD, HPD, MAOA, MAOB, PNMT, TAT, TH, TPO, TYR 32 ABP1(22), ADH1A(17), ADH1B(30), ADH1C(1), ADH4(10), ADH6(14), ADH7(16), ADHFE1(6), ALDH1A3(2), ALDH3A1(8), ALDH3B1(3), ALDH3B2(8), AOC2(9), AOC3(10), AOX1(26), COMT(3), DBH(15), DCT(4), DDC(14), FAH(4), GOT1(6), GOT2(6), GSTZ1(1), HGD(13), HPD(7), MAOA(4), MAOB(13), PNMT(4), TAT(19), TH(12), TPO(47), TYR(9) 12889895 363 140 337 185 267 23 17 22 34 0 0.00741 1.000 1.000 165 WNT_SIGNALING Wnt signaling genes APC, ARHA, AXIN1, C2orf31, CCND1, CCND2, CCND3, CSNK1E, CSNK1E, LOC400927, CTNNB1, DIPA, DVL1, DVL2, DVL3, FBXW2, FOSL1, FRAT1, FZD1, FZD10, FZD2, FZD3, FZD5, FZD6, FZD7, FZD8, FZD9, GSK3B, JUN, LDLR, MAPK10, MAPK9, MYC, PAFAH1B1, PLAU, PPP2R5C, PPP2R5E, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCI, PRKCM, PRKCQ, PRKCZ, PRKD1, RAC1, RHOA, SFRP4, TCF7, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B 57 APC(25), AXIN1(9), CCND1(2), CCND2(6), CCND3(2), CSNK1E(5), CTNNB1(14), DVL2(3), DVL3(8), FBXW2(2), FZD1(5), FZD10(4), FZD2(6), FZD3(1), FZD5(2), FZD6(2), FZD7(4), FZD8(5), FZD9(1), GSK3B(3), JUN(1), LDLR(17), MAPK10(9), MAPK9(3), MYC(5), PAFAH1B1(4), PLAU(3), PPP2R5C(4), PPP2R5E(5), PRKCA(8), PRKCD(5), PRKCE(6), PRKCG(16), PRKCH(9), PRKCI(8), PRKCQ(20), PRKCZ(7), PRKD1(9), RHOA(2), SFRP4(5), TCF7(1), WNT1(2), WNT10A(7), WNT10B(6), WNT11(4), WNT16(3), WNT2(8), WNT2B(5), WNT3(5), WNT4(1), WNT5A(5), WNT5B(4), WNT6(3), WNT7A(14), WNT7B(6) 24187840 329 140 322 184 198 33 10 35 53 0 0.380 1.000 1.000 166 HSA00052_GALACTOSE_METABOLISM Genes involved in galactose metabolism AKR1B1, AKR1B10, B4GALT1, B4GALT2, G6PC, G6PC2, GAA, GALE, GALK1, GALK2, GALT, GANC, GCK, GLA, GLB1, HK1, HK2, HK3, HSD3B7, LALBA, LCT, MGAM, PFKL, PFKM, PFKP, PGM1, PGM3, RDH11, RDH12, RDH13, RDH14, UGP2 32 AKR1B1(2), AKR1B10(9), B4GALT1(2), B4GALT2(2), G6PC(5), G6PC2(4), GAA(8), GALK1(2), GALK2(2), GALT(2), GANC(7), GCK(17), GLA(2), GLB1(9), HK1(3), HK2(13), HK3(14), HSD3B7(5), LALBA(7), LCT(51), MGAM(162), PFKL(4), PFKM(2), PFKP(2), PGM1(6), PGM3(1), RDH11(1), RDH12(2), RDH13(3), UGP2(1) 15716260 350 139 327 187 258 28 7 30 27 0 0.0212 1.000 1.000 167 LAIRPATHWAY The local acute inflammatory response is mediated by activated macrophages and mast cells or by complement activation. BDK, C3, C5, C6, C7, ICAM1, IL1A, IL6, IL8, ITGA4, ITGAL, ITGB1, ITGB2, SELP, SELPLG, TNF, VCAM1 16 C3(48), C5(21), C6(72), C7(47), ICAM1(2), IL1A(5), IL6(2), IL8(1), ITGA4(43), ITGAL(28), ITGB1(4), ITGB2(16), SELP(39), SELPLG(10), TNF(1), VCAM1(17) 10051578 356 138 323 143 256 9 14 34 41 2 0.000211 1.000 1.000 168 OVARIAN_INFERTILITY_GENES ATM, BMPR1B, CCND2, CDK4, CDKN1B, CEBPB, DAZL, DMC1, EGR1, ESR2, FSHR, GJA4, INHA, LHCGR, MLH1, MSH5, NCOR1, NR5A1, NRIP1, PGR, PRLR, PTGER2, SMPD1, VDR, ZP2 24 ATM(15), BMPR1B(4), CCND2(6), CDK4(7), CDKN1B(1), DAZL(5), EGR1(4), ESR2(9), FSHR(19), GJA4(4), INHA(4), LHCGR(27), MLH1(6), MSH5(17), NCOR1(23), NR5A1(9), NRIP1(8), PGR(16), PRLR(35), PTGER2(7), SMPD1(2), VDR(3), ZP2(16) 13938631 247 137 225 128 162 18 8 28 31 0 0.593 1.000 1.000 169 GALACTOSE_METABOLISM AKR1B1, B4GALT1, B4GALT2, FBP2, G6PC, GAA, GALE, GALK1, GALK2, GALT, GANAB, GCK, GLA, GLB1, HK1, HK2, HK3, LALBA, LCT, MGAM, PFKM, PFKP, PGM1, PGM3 24 AKR1B1(2), B4GALT1(2), B4GALT2(2), FBP2(2), G6PC(5), GAA(8), GALK1(2), GALK2(2), GALT(2), GANAB(5), GCK(17), GLA(2), GLB1(9), HK1(3), HK2(13), HK3(14), LALBA(7), LCT(51), MGAM(162), PFKM(2), PFKP(2), PGM1(6), PGM3(1) 13248986 321 136 298 169 236 28 7 26 24 0 0.0209 1.000 1.000 170 BETA_ALANINE_METABOLISM ABAT, ABP1, ACADL, ACADM, ACADSB, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, AOC2, AOC3, CNDP1, DPYD, DPYS, ECHS1, EHHADH, GAD1, GAD2, HADHA, MLYCD, SDS, SMS, UPB1 27 ABAT(9), ABP1(22), ACADL(5), ACADM(4), ACADSB(5), ALDH1A1(5), ALDH1A2(14), ALDH1A3(2), ALDH1B1(11), ALDH2(7), ALDH3A1(8), ALDH3A2(3), ALDH9A1(2), AOC2(9), AOC3(10), CNDP1(8), DPYD(67), DPYS(24), ECHS1(3), EHHADH(6), GAD1(13), GAD2(9), HADHA(6), MLYCD(2), SDS(2), SMS(4), UPB1(10) 11869958 270 135 249 125 178 21 13 31 27 0 0.0327 1.000 1.000 171 HSA00512_O_GLYCAN_BIOSYNTHESIS Genes involved in O-glycan biosynthesis B3GNT6, B4GALT5, C1GALT1, C1GALT1C1, GALNT1, GALNT10, GALNT11, GALNT12, GALNT13, GALNT14, GALNT17, GALNT2, GALNT3, GALNT4, GALNT5, GALNT6, GALNT7, GALNT8, GALNT9, GALNTL1, GALNTL2, GALNTL4, GALNTL5, GCNT1, GCNT3, GCNT4, OGT, ST3GAL1, ST3GAL2, ST6GALNAC1, WBSCR17 30 B3GNT6(1), B4GALT5(2), C1GALT1(6), C1GALT1C1(3), GALNT1(4), GALNT10(7), GALNT11(2), GALNT12(8), GALNT13(29), GALNT14(24), GALNT2(6), GALNT3(4), GALNT4(5), GALNT5(13), GALNT6(17), GALNT7(4), GALNT8(27), GALNT9(7), GALNTL1(6), GALNTL2(22), GALNTL4(10), GALNTL5(18), GCNT1(6), GCNT3(7), GCNT4(4), OGT(10), ST3GAL1(7), ST3GAL2(1), ST6GALNAC1(8), WBSCR17(44) 13183740 312 135 292 147 219 14 7 32 40 0 0.0819 1.000 1.000 172 HSA00591_LINOLEIC_ACID_METABOLISM Genes involved in linoleic acid metabolism AKR1B10, ALOX15, ALOX5, CYP1A2, CYP2C18, CYP2C19, CYP2C8, CYP2C9, CYP2E1, CYP2J2, CYP3A4, CYP3A43, CYP3A5, CYP3A7, HSD3B7, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, RDH11, RDH12, RDH13, RDH14 31 AKR1B10(9), ALOX15(10), ALOX5(12), CYP1A2(8), CYP2C19(75), CYP2C8(32), CYP2C9(38), CYP2E1(13), CYP2J2(7), CYP3A4(20), CYP3A43(19), CYP3A7(30), HSD3B7(5), PLA2G12B(4), PLA2G1B(1), PLA2G2A(2), PLA2G2D(5), PLA2G2E(5), PLA2G2F(6), PLA2G3(17), PLA2G4A(15), PLA2G5(2), PLA2G6(12), RDH11(1), RDH12(2), RDH13(3) 9744459 353 135 329 189 261 17 10 14 49 2 0.00886 1.000 1.000 173 PPARAPATHWAY Peroxisome proliferators regulate gene expression via PPAR/RXR heterodimers which bind to peroxisome-proliferator response elements (PPREs). ACOX1, APOA1, APOA2, CD36, CITED2, CPT1B, CREBBP, DUSP1, DUT, EHHADH, EP300, FABP1, FAT, FRA8B, HSD17B4, HSPA1A, HSPCA, INS, JUN, LPL, MAPK1, MAPK3, ME1, MRPL11, MYC, NCOA1, NCOR1, NCOR2, NFKBIA, NOS2A, NR0B2, NR1H3, NR2F1, NRIP1, PDGFA, PIK3CA, PIK3R1, PPARA, PPARBP, PPARGC1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PTGS2, RB1, RELA, RXRA, SP1, SRA1, STAT5A, STAT5B, TNF 50 ACOX1(8), APOA1(2), CD36(6), CPT1B(8), CREBBP(24), DUSP1(1), EHHADH(6), EP300(18), FABP1(6), HSD17B4(6), JUN(1), LPL(6), MAPK1(4), MAPK3(4), ME1(20), MRPL11(1), MYC(5), NCOA1(9), NCOR1(23), NCOR2(26), NFKBIA(2), NR0B2(6), NR1H3(3), NR2F1(8), NRIP1(8), PDGFA(1), PIK3CA(10), PIK3R1(2), PPARA(7), PRKACB(4), PRKACG(11), PRKAR1A(3), PRKAR1B(4), PRKAR2A(1), PRKAR2B(5), PRKCA(8), PTGS2(13), RB1(10), RELA(4), RXRA(4), SP1(5), STAT5A(3), STAT5B(6), TNF(1) 25873832 313 134 304 142 194 30 22 32 31 4 0.125 1.000 1.000 174 ST_JNK_MAPK_PATHWAY JNKs are MAP kinases regulated by several levels of kinases (MAPKK, MAPKKK) and phosphorylate transcription factors and regulatory proteins. AKT1, ATF2, CDC42, DLD, DUSP10, DUSP4, DUSP8, GAB1, GADD45A, GCK, IL1R1, JUN, MAP2K4, MAP2K5, MAP2K7, MAP3K1, MAP3K10, MAP3K11, MAP3K12, MAP3K13, MAP3K2, MAP3K3, MAP3K4, MAP3K5, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAP3K9, MAPK10, MAPK7, MAPK8, MAPK9, MYEF2, NFATC3, NR2C2, PAPPA, SHC1, TP53, TRAF6, ZAK 37 AKT1(4), ATF2(6), CDC42(2), DLD(3), DUSP10(7), DUSP4(2), DUSP8(3), GAB1(8), GCK(17), IL1R1(13), JUN(1), MAP2K4(4), MAP2K5(4), MAP2K7(5), MAP3K1(4), MAP3K10(9), MAP3K11(6), MAP3K12(3), MAP3K13(15), MAP3K2(6), MAP3K3(8), MAP3K4(17), MAP3K5(23), MAP3K7(1), MAP3K9(26), MAPK10(9), MAPK7(4), MAPK8(1), MAPK9(3), MYEF2(4), NFATC3(10), NR2C2(1), PAPPA(59), SHC1(2), TRAF6(4) 20180505 294 134 283 142 200 25 8 30 30 1 0.497 1.000 1.000 175 FCER1PATHWAY In mast cells, Fc epsilon receptor 1 activates BTK, PKC, and the MAP kinase pathway to promote degranulation and arachnidonic acid release. BTK, CALM1, CALM2, CALM3, ELK1, FCER1A, FCER1G, FOS, GRB2, HRAS, JUN, LYN, MAP2K1, MAP2K4, MAP2K7, MAP3K1, MAPK1, MAPK3, MAPK8, NFATC1, NFATC2, NFATC3, NFATC4, PAK2, PIK3CA, PIK3R1, PLA2G4A, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCB1, RAF1, SHC1, SOS1, SYK, SYT1, VAV1 37 BTK(16), CALM1(1), CALM2(1), ELK1(3), FCER1A(15), FCER1G(1), FOS(2), GRB2(2), HRAS(3), JUN(1), LYN(10), MAP2K1(14), MAP2K4(4), MAP2K7(5), MAP3K1(4), MAPK1(4), MAPK3(4), MAPK8(1), NFATC1(16), NFATC2(11), NFATC3(10), NFATC4(17), PAK2(7), PIK3CA(10), PIK3R1(2), PLA2G4A(15), PLCG1(8), PPP3CA(5), PPP3CB(3), PPP3CC(2), RAF1(10), SHC1(2), SOS1(10), SYK(14), SYT1(23), VAV1(19) 17529063 275 133 260 125 170 17 14 35 38 1 0.300 1.000 1.000 176 PYRIMIDINE_METABOLISM AK3, AK3L1, AK3L1, AK3L2, CAD, CANT1, CDA, CMPK, CTPS, CTPS2, DCK, DCTD, DHODH, DPYD, DPYS, DTYMK, DUT, ECGF1, ENTPD1, ITPA, NME1, NME2, NP, NT5C, NT5E, NT5M, NUDT2, POLA, POLB, POLD1, POLD2, POLE, POLG, POLL, POLQ, POLR1B, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLRMT, POLS, RRM1, RRM2, TK1, TK2, TXNRD1, TYMS, UCK1, UCK2, UMPS, UNG, UPB1, UPP1 55 CAD(18), CANT1(10), CDA(3), CTPS2(5), DCTD(3), DHODH(5), DPYD(67), DPYS(24), ENTPD1(12), ITPA(1), NT5E(6), NT5M(2), NUDT2(1), POLB(1), POLD1(7), POLD2(2), POLE(16), POLG(9), POLL(8), POLQ(25), POLR1B(9), POLR2A(13), POLR2B(12), POLR2C(1), POLR2D(1), POLR2E(3), POLR2F(1), POLR2H(2), POLR2J(1), POLRMT(3), RRM1(3), RRM2(3), TK2(1), TXNRD1(5), TYMS(1), UCK1(3), UCK2(1), UMPS(2), UNG(5), UPB1(10), UPP1(1) 23406964 306 133 285 132 195 27 10 42 32 0 0.00574 1.000 1.000 177 ST_DIFFERENTIATION_PATHWAY_IN_PC12_CELLS Rat-derived PC12 cells respond to nerve growth factor (NGF) and PACAP to differentiate into neuronal cells. AKT1, ASAH1, ATF1, BRAF, CAMP, CREB1, CREB3, CREB5, CREBBP, CRKL, DAG1, EGR1, EGR2, EGR3, EGR4, ELK1, FRS2, GAS, GNAQ, GRF2, JUN, MAP1B, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK3, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, NTRK1, OPN1LW, PACAP, PIK3C2G, PIK3CA, PIK3CD, PIK3R1, PTPN11, RPS6KA3, SH2B, SHC1, SRC, TERF2IP, TH, TUBA3 41 AKT1(4), ATF1(4), CAMP(2), CREB3(1), CREB5(9), CREBBP(24), CRKL(3), DAG1(9), EGR1(4), EGR2(5), EGR3(4), EGR4(5), ELK1(3), FRS2(7), GNAQ(6), JUN(1), MAP1B(25), MAP2K4(4), MAP2K7(5), MAPK1(4), MAPK10(9), MAPK3(4), MAPK8(1), MAPK8IP1(7), MAPK8IP2(7), MAPK8IP3(10), MAPK9(3), NTRK1(16), OPN1LW(8), PIK3C2G(53), PIK3CA(10), PIK3CD(8), PIK3R1(2), PTPN11(10), RPS6KA3(1), SHC1(2), SRC(2), TERF2IP(1), TH(12) 20240620 295 133 277 153 193 26 13 34 28 1 0.423 1.000 1.000 178 GLYCOLYSIS_AND_GLUCONEOGENESIS Genes involved in glycolysis and gluconeogenesis ALDOA, ALDOB, ALDOC, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, GAPDH, GAPDHS, GAPDS, GCK, GOT1, GOT2, GPI, HK1, HK2, HK3, LDHA, LDHAL6B, LDHB, LDHC, MDH1, MDH2, PC, PCK1, PDHA1, PDHA2, PDHB, PDHX, PFKL, PFKM, PFKP, PGAM1, PGAM2, PGK1, PGK2, PKLR, PKM2, TNFAIP1, TPI1 43 ALDOA(2), ALDOB(14), ALDOC(4), DLAT(4), DLD(3), ENO1(4), ENO2(5), ENO3(3), FBP1(3), FBP2(2), G6PC(5), GAPDH(2), GAPDHS(3), GCK(17), GOT1(6), GOT2(6), GPI(3), HK1(3), HK2(13), HK3(14), LDHA(4), LDHAL6B(6), LDHB(2), LDHC(5), MDH1(3), MDH2(3), PC(14), PCK1(25), PDHA1(4), PDHA2(20), PDHB(1), PDHX(2), PFKL(4), PFKM(2), PFKP(2), PGAM2(3), PGK1(2), PGK2(35), PKLR(13), PKM2(7), TNFAIP1(1), TPI1(1) 17354578 275 132 261 142 194 21 14 20 26 0 0.00852 1.000 1.000 179 HSA04150_MTOR_SIGNALING_PATHWAY Genes involved in mTOR signaling pathway AKT1, AKT2, AKT3, BRAF, CAB39, DDIT4, EIF4B, EIF4EBP1, FIGF, FRAP1, GBL, HIF1A, IGF1, INS, KIAA1303, LYK5, MAPK1, MAPK3, PDPK1, PGF, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PRKAA1, PRKAA2, RHEB, RICTOR, RPS6, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA6, RPS6KB1, RPS6KB2, STK11, TSC1, TSC2, ULK1, ULK2, ULK3, VEGFA, VEGFB, VEGFC 42 AKT1(4), AKT2(8), AKT3(3), CAB39(1), EIF4B(5), EIF4EBP1(1), FIGF(5), HIF1A(4), IGF1(10), MAPK1(4), MAPK3(4), PDPK1(3), PGF(1), PIK3CA(10), PIK3CB(14), PIK3CD(8), PIK3CG(27), PIK3R1(2), PIK3R2(5), PIK3R3(2), PIK3R5(16), PRKAA1(1), PRKAA2(30), RHEB(1), RICTOR(12), RPS6(1), RPS6KA1(8), RPS6KA2(6), RPS6KA3(1), RPS6KA6(19), RPS6KB1(3), RPS6KB2(2), STK11(4), TSC1(9), TSC2(12), ULK1(9), ULK2(7), ULK3(1), VEGFA(4), VEGFB(2) 20551299 269 132 254 133 161 22 13 37 34 2 0.311 1.000 1.000 180 HSA00410_BETA_ALANINE_METABOLISM Genes involved in beta-alanine metabolism ABAT, ABP1, ACADM, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, AOC2, AOC3, CNDP1, DPYD, DPYS, ECHS1, EHHADH, GAD1, GAD2, HADHA, HIBCH, MLYCD, SMS, SRM, UPB1 25 ABAT(9), ABP1(22), ACADM(4), ALDH1A3(2), ALDH1B1(11), ALDH2(7), ALDH3A1(8), ALDH3A2(3), ALDH7A1(9), ALDH9A1(2), AOC2(9), AOC3(10), CNDP1(8), DPYD(67), DPYS(24), ECHS1(3), EHHADH(6), GAD1(13), GAD2(9), HADHA(6), HIBCH(1), MLYCD(2), SMS(4), SRM(1), UPB1(10) 11040571 250 131 230 121 163 20 14 29 24 0 0.0762 1.000 1.000 181 ST_ADRENERGIC Adrenergic receptors respond to epinephrine and norepinephrine signaling. AKT1, APC, AR, ASAH1, BF, BRAF, CAMP, CCL13, CCL15, CCL16, DAG1, EGFR, GAS, GNA11, GNA15, GNAI1, GNAQ, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, KCNJ3, KCNJ5, KCNJ9, MAPK1, MAPK10, MAPK14, PHKA2, PIK3CA, PIK3CD, PIK3R1, PITX2, PTX1, PTX3, RAF1, SRC 33 AKT1(4), APC(25), AR(10), CAMP(2), CCL15(3), CCL16(2), DAG1(9), EGFR(25), GNA11(8), GNA15(6), GNAI1(2), GNAQ(6), ITPKB(11), ITPR1(36), ITPR2(20), ITPR3(11), KCNJ3(20), KCNJ5(13), KCNJ9(6), MAPK1(4), MAPK10(9), MAPK14(5), PHKA2(9), PIK3CA(10), PIK3CD(8), PIK3R1(2), PITX2(5), PTX3(1), RAF1(10), SRC(2) 21050286 284 131 274 164 175 22 17 35 34 1 0.581 1.000 1.000 182 BIOPEPTIDESPATHWAY Extracellular signaling peptides exert biological effects via G-protein coupled receptors (GPCRs), which activate intracellular GTPases. AGT, AGTR2, BDK, CALM1, CALM2, CALM3, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CDK5, F2, FYN, GNA11, GNAI1, GNB1, GNGT1, GRB2, HRAS, JAK2, MAP2K1, MAP2K2, MAPK1, MAPK14, MAPK3, MAPK8, MAPT, MYLK, PLCG1, PRKCA, PRKCB1, PTK2B, RAF1, SHC1, SOS1, STAT1, STAT3, STAT5A, SYT1 37 AGT(8), AGTR2(9), CALM1(1), CALM2(1), CAMK2A(6), CAMK2B(6), CAMK2D(6), CAMK2G(5), CDK5(6), F2(11), FYN(7), GNA11(8), GNAI1(2), GNB1(1), GRB2(2), HRAS(3), JAK2(8), MAP2K1(14), MAP2K2(5), MAPK1(4), MAPK14(5), MAPK3(4), MAPK8(1), MAPT(11), MYLK(46), PLCG1(8), PRKCA(8), PTK2B(10), RAF1(10), SHC1(2), SOS1(10), STAT1(5), STAT3(9), STAT5A(3), SYT1(23) 16912986 268 130 248 149 167 22 13 35 31 0 0.490 1.000 1.000 183 GPCRDB_CLASS_C_METABOTROPIC_GLUTAMATE_PHEROMONE CASR, GABBR1, GPCR5A, GPR51, GPRC5A, GPRC5B, GPRC5C, GPRC5D, GRM1, GRM2, GRM3, GRM4, GRM5, GRM7, GRM8 13 CASR(65), GABBR1(8), GPRC5A(4), GPRC5B(5), GPRC5C(10), GPRC5D(2), GRM1(16), GRM2(13), GRM3(62), GRM4(21), GRM5(15), GRM7(40), GRM8(48) 8535385 309 130 288 218 225 21 12 23 28 0 0.190 1.000 1.000 184 HSA00650_BUTANOATE_METABOLISM Genes involved in butanoate metabolism AACS, AADAC, ABAT, ACADS, ACAT1, ACAT2, ACSM1, AKR1B10, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH5A1, ALDH7A1, ALDH9A1, BDH1, BDH2, DDHD1, ECHS1, EHHADH, GAD1, GAD2, HADH, HADHA, HMGCL, HMGCS1, HMGCS2, HSD17B10, HSD17B4, HSD3B7, ILVBL, L2HGDH, OXCT1, OXCT2, PDHA1, PDHA2, PDHB, PLA1A, PPME1, PRDX6, RDH11, RDH12, RDH13, RDH14 45 AACS(8), AADAC(15), ABAT(9), ACADS(5), ACAT2(1), ACSM1(28), AKR1B10(9), ALDH1A3(2), ALDH1B1(11), ALDH2(7), ALDH3A1(8), ALDH3A2(3), ALDH5A1(10), ALDH7A1(9), ALDH9A1(2), BDH1(5), DDHD1(7), ECHS1(3), EHHADH(6), GAD1(13), GAD2(9), HADH(2), HADHA(6), HMGCL(4), HMGCS1(3), HMGCS2(21), HSD17B10(2), HSD17B4(6), HSD3B7(5), ILVBL(5), L2HGDH(3), OXCT1(4), OXCT2(5), PDHA1(4), PDHA2(20), PDHB(1), PLA1A(10), PPME1(1), PRDX6(4), RDH11(1), RDH12(2), RDH13(3) 16580170 282 130 271 134 185 26 18 21 32 0 0.0350 1.000 1.000 185 ST_DICTYOSTELIUM_DISCOIDEUM_CAMP_CHEMOTAXIS_PATHWAY The fungus Dictyostelium discoideum is a model system for cytoskeletal organization during chemotaxis. ACTR2, ACTR3, AKT1, ANGPTL2, BF, DAG1, DGKA, ETFA, GCA, ITGA9, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, MAP2K1, MAPK1, MAPK3, NR1I3, PAK1, PDE3A, PDE3B, PI3, PIK3C2G, PIK3CA, PIK3CD, PIK3R1, PLDN, PSME1, RIPK3, RPS4X, SGCB, VASP 32 ACTR2(3), ACTR3(2), AKT1(4), ANGPTL2(2), DAG1(9), DGKA(3), ETFA(3), GCA(3), ITGA9(13), ITPKB(11), ITPR1(36), ITPR2(20), ITPR3(11), MAP2K1(14), MAPK1(4), MAPK3(4), NR1I3(6), PAK1(4), PDE3A(29), PDE3B(6), PI3(6), PIK3C2G(53), PIK3CA(10), PIK3CD(8), PIK3R1(2), RIPK3(11), VASP(3) 19761567 280 130 255 117 190 21 13 26 29 1 0.000908 1.000 1.000 186 ST_WNT_BETA_CATENIN_PATHWAY Beta-catenin is degraded in the absence of Wnt signaling; when extracellular Wnt binds Frizzled receptors, beta-catenin accumulates in the nucleus and may promote cell survival. AKT1, AKT2, AKT3, ANKRD6, APC, AXIN1, AXIN2, C22orf2, CER1, CSNK1A1, CTNNB1, DACT1, DKK1, DKK2, DKK3, DKK4, DVL1, FRAT1, FSTL1, GSK3A, GSK3B, IDAX, LAMR1, LRP1, MVP, NKD1, NKD2, PIN1, PSEN1, PTPRA, SENP2, SFRP1, TSHB, WIF1 30 AKT1(4), AKT2(8), AKT3(3), ANKRD6(3), APC(25), AXIN1(9), AXIN2(4), CER1(16), CSNK1A1(3), CTNNB1(14), DACT1(13), DKK1(2), DKK2(19), DKK3(4), DKK4(3), FSTL1(3), GSK3A(1), GSK3B(3), LRP1(40), MVP(11), NKD1(8), NKD2(7), PIN1(1), PSEN1(1), PTPRA(9), SENP2(14), SFRP1(3), TSHB(6), WIF1(7) 16324165 244 130 235 117 138 30 10 30 36 0 0.204 1.000 1.000 187 HSA00620_PYRUVATE_METABOLISM Genes involved in pyruvate metabolism ACACA, ACACB, ACAT1, ACAT2, ACOT12, ACSS1, ACSS2, ACYP1, ACYP2, AKR1B1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, DLAT, DLD, GLO1, GRHPR, HAGH, HAGHL, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, LDHD, MDH1, MDH2, ME1, ME2, ME3, PC, PCK1, PCK2, PDHA1, PDHA2, PDHB, PKLR, PKM2 42 ACACA(20), ACACB(23), ACAT2(1), ACOT12(14), ACSS1(2), ACSS2(4), ACYP1(1), AKR1B1(2), ALDH1A3(2), ALDH1B1(11), ALDH2(7), ALDH3A1(8), ALDH3A2(3), ALDH7A1(9), ALDH9A1(2), DLAT(4), DLD(3), GLO1(1), GRHPR(1), HAGH(2), LDHA(4), LDHAL6A(4), LDHAL6B(6), LDHB(2), LDHC(5), LDHD(1), MDH1(3), MDH2(3), ME1(20), ME2(2), ME3(8), PC(14), PCK1(25), PCK2(6), PDHA1(4), PDHA2(20), PDHB(1), PKLR(13), PKM2(7) 19122977 268 128 259 147 170 18 18 32 29 1 0.355 1.000 1.000 188 METPATHWAY The hepatocyte growth factor receptor c-Met stimulates proliferation and alters cell motility and adhesion on binding the ligand HGF. ACTA1, CRK, CRKL, DOCK1, ELK1, FOS, GAB1, GRB2, GRF2, HGF, HRAS, ITGA1, ITGB1, JUN, MAP2K1, MAP2K2, MAP4K1, MAPK1, MAPK3, MAPK8, MET, PAK1, PIK3CA, PIK3R1, PTEN, PTK2, PTK2B, PTPN11, PXN, RAF1, RAP1A, RAP1B, RASA1, SOS1, SRC, STAT3 34 ACTA1(4), CRK(3), CRKL(3), DOCK1(17), ELK1(3), FOS(2), GAB1(8), GRB2(2), HGF(29), HRAS(3), ITGA1(24), ITGB1(4), JUN(1), MAP2K1(14), MAP2K2(5), MAP4K1(11), MAPK1(4), MAPK3(4), MAPK8(1), MET(23), PAK1(4), PIK3CA(10), PIK3R1(2), PTK2(7), PTK2B(10), PTPN11(10), PXN(2), RAF1(10), RAP1A(2), RAP1B(1), RASA1(4), SOS1(10), SRC(2), STAT3(9) 17490554 248 128 232 118 147 20 9 42 29 1 0.554 1.000 1.000 189 CCR3PATHWAY CCR3 is a G-protein coupled receptor that recruits eosinophils to inflammation sites via chemokine ligands. ARHA, CCL11, CCR3, CFL1, GNAQ, GNAS, GNB1, GNGT1, HRAS, LIMK1, MAP2K1, MAPK1, MAPK3, MYL2, NOX1, PIK3C2G, PLCB1, PPP1R12B, PRKCA, PRKCB1, PTK2, RAF1, ROCK2 21 CCL11(3), CCR3(10), CFL1(2), GNAQ(6), GNAS(25), GNB1(1), HRAS(3), LIMK1(5), MAP2K1(14), MAPK1(4), MAPK3(4), MYL2(9), NOX1(13), PIK3C2G(53), PLCB1(54), PPP1R12B(7), PRKCA(8), PTK2(7), RAF1(10), ROCK2(11) 10209280 249 127 218 95 168 13 7 35 26 0 0.0124 1.000 1.000 190 BCRPATHWAY B cell antigen receptors (BCRs) activate tyrosine kinases and transiently increase tyrosine phosphorylation on binding to antigen. BLNK, BTK, CALM1, CALM2, CALM3, CD79A, CD79B, ELK1, FOS, GRB2, HRAS, JUN, LYN, MAP2K1, MAP3K1, MAPK14, MAPK3, MAPK8, NFATC1, NFATC2, NFATC3, NFATC4, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, RAC1, RAF1, SHC1, SOS1, SYK, SYT1, VAV1 33 BLNK(15), BTK(16), CALM1(1), CALM2(1), CD79A(3), ELK1(3), FOS(2), GRB2(2), HRAS(3), JUN(1), LYN(10), MAP2K1(14), MAP3K1(4), MAPK14(5), MAPK3(4), MAPK8(1), NFATC1(16), NFATC2(11), NFATC3(10), NFATC4(17), PLCG1(8), PPP3CA(5), PPP3CB(3), PPP3CC(2), PRKCA(8), RAF1(10), SHC1(2), SOS1(10), SYK(14), SYT1(23), VAV1(19) 15427589 243 126 229 113 155 15 10 30 33 0 0.303 1.000 1.000 191 HSA00120_BILE_ACID_BIOSYNTHESIS Genes involved in bile acid biosynthesis ACAA1, ACAA2, ACAD8, ACAD9, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AKR1B10, AKR1C4, AKR1D1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, BAAT, CEL, CYP27A1, CYP7A1, HADHB, HSD3B7, LIPA, RDH11, RDH12, RDH13, RDH14, SLC27A5, SOAT1, SOAT2, SRD5A1, SRD5A2 38 ACAA1(6), ACAA2(1), ACAD8(3), ACAD9(2), ADH1A(17), ADH1B(30), ADH1C(1), ADH4(10), ADH5(3), ADH6(14), ADH7(16), ADHFE1(6), AKR1B10(9), AKR1C4(10), AKR1D1(19), ALDH1A3(2), ALDH1B1(11), ALDH2(7), ALDH3A1(8), ALDH3A2(3), ALDH7A1(9), ALDH9A1(2), BAAT(13), CEL(13), CYP27A1(3), CYP7A1(8), HADHB(5), HSD3B7(5), LIPA(5), RDH11(1), RDH12(2), RDH13(3), SLC27A5(9), SOAT1(3), SOAT2(5), SRD5A1(2), SRD5A2(6) 12945471 272 126 245 122 180 26 21 21 24 0 0.00246 1.000 1.000 192 ANDROGEN_AND_ESTROGEN_METABOLISM AKR1C4, AKR1D1, ARSB, ARSD, ARSE, CYP11B1, CYP11B2, HSD11B1, HSD11B2, HSD17B2, HSD17B3, HSD17B8, HSD3B1, HSD3B2, SRD5A1, SRD5A2, STS, SULT1E1, SULT2A1, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4 29 AKR1C4(10), AKR1D1(19), ARSB(2), ARSD(3), ARSE(5), CYP11B1(18), CYP11B2(14), HSD11B2(3), HSD17B2(12), HSD17B3(5), HSD3B1(14), HSD3B2(14), SRD5A1(2), SRD5A2(6), STS(7), SULT1E1(16), SULT2A1(9), UGT1A1(77), UGT2B15(31), UGT2B4(34) 10865253 301 125 276 132 203 30 11 18 38 1 0.000470 1.000 1.000 193 COMPLEMENT_ACTIVATION_CLASSICAL C1QA, C1QB, C1QG, C1R, C1S, C2, C3, C4A, C4B, C5, C6, C7, C8A, C8B, C9, DAF, MASP1 12 C1QA(6), C1QB(7), C1R(16), C1S(20), C3(48), C5(21), C6(72), C7(47), C8B(46), C9(22), MASP1(10) 7924862 315 124 283 134 233 14 9 28 29 2 0.00376 1.000 1.000 194 NUCLEAR_RECEPTORS ALK, AR, ESR1, ESR2, ESRRA, HNF4A, NPM1, NR0B1, NR1D2, NR1H2, NR1H3, NR1I2, NR1I3, NR2C2, NR2E1, NR2F1, NR2F2, NR2F6, NR3C1, NR4A1, NR4A2, NR5A1, NR5A2, PGR, PPARA, PPARD, PPARG, RARA, RARB, RARG, ROR1, RORA, RORC, RXRA, RXRB, RXRG, THRA, THRA, NR1D1, THRB, VDR 40 ALK(36), AR(10), ESR1(6), ESR2(9), ESRRA(3), HNF4A(20), NPM1(2), NR0B1(3), NR1D1(1), NR1D2(10), NR1H2(4), NR1H3(3), NR1I2(4), NR1I3(6), NR2C2(1), NR2E1(5), NR2F1(8), NR2F2(2), NR2F6(1), NR3C1(7), NR4A1(4), NR4A2(4), NR5A1(9), NR5A2(21), PGR(16), PPARA(7), PPARD(3), PPARG(14), RARA(4), RARB(9), RARG(3), ROR1(15), RORA(5), RORC(13), RXRA(4), RXRB(4), RXRG(6), THRA(2), THRB(18), VDR(3) 17023069 305 124 291 145 211 27 8 22 37 0 0.0135 1.000 1.000 195 PROSTAGLANDIN_AND_LEUKOTRIENE_METABOLISM AKR1C3, ALOX12, ALOX15, ALOX5, CBR1, CBR3, CYP4F2, CYP4F3, CYP4F3, CYP4F2, EPX, GGT1, LPO, LTA4H, MPO, PGDS, PLA2G1B, PLA2G2A, PLA2G2E, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PRDX1, PRDX2, PRDX5, PRDX6, PTGDS, PTGES2, PTGIS, PTGS1, PTGS2, TBXAS1, TPO 31 AKR1C3(14), ALOX12(6), ALOX15(10), ALOX5(12), CBR3(1), CYP4F2(16), CYP4F3(24), EPX(9), GGT1(8), LPO(20), LTA4H(5), MPO(11), PLA2G1B(1), PLA2G2A(2), PLA2G2E(5), PLA2G3(17), PLA2G4A(15), PLA2G5(2), PLA2G6(12), PRDX1(3), PRDX2(3), PRDX6(4), PTGDS(3), PTGES2(1), PTGIS(17), PTGS1(20), PTGS2(13), TBXAS1(16), TPO(47) 11377234 317 124 308 162 218 27 5 25 41 1 0.00196 1.000 1.000 196 SIG_INSULIN_RECEPTOR_PATHWAY_IN_CARDIAC_MYOCYTES Genes related to the insulin receptor pathway AKT1, AKT2, AKT3, BRD4, CAP1, CBL, CDC42, CDKN2A, F2RL2, FLOT1, FLOT2, FOXO1A, GRB2, GSK3A, GSK3B, IGFBP1, INPPL1, IRS1, IRS2, IRS4, LNPEP, MAPK1, MAPK3, PARD3, PARD6A, PDK1, PIK3CA, PIK3CD, PIK3R1, PPYR1, PSCD3, PTEN, PTPN1, RAF1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SERPINB6, SFN, SHC1, SLC2A4, SORBS1, SOS1, SOS2, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ 47 AKT1(4), AKT2(8), AKT3(3), BRD4(21), CAP1(2), CBL(10), CDC42(2), F2RL2(8), FLOT1(2), GRB2(2), GSK3A(1), GSK3B(3), IGFBP1(4), INPPL1(16), IRS1(5), IRS2(3), IRS4(13), LNPEP(11), MAPK1(4), MAPK3(4), PARD3(18), PARD6A(1), PDK1(2), PIK3CA(10), PIK3CD(8), PIK3R1(2), PPYR1(14), PTPN1(4), RAF1(10), RPS6KA1(8), RPS6KA2(6), RPS6KA3(1), RPS6KB1(3), SERPINB6(4), SHC1(2), SLC2A4(9), SORBS1(15), SOS1(10), SOS2(13), YWHAB(1), YWHAE(2), YWHAG(2), YWHAQ(3) 23784663 274 124 270 139 148 32 16 45 32 1 0.583 1.000 1.000 197 ST_GA13_PATHWAY G-alpha-13 influences the actin cytoskeleton and activates protein kinase D, PI3K, and Pyk2. AKT1, AKT2, AKT3, ARHGEF11, BCL2, BF, CDC42, DLG4, GNA13, IKBKG, LPA, MAP2K4, MAP3K1, MAP3K5, MAPK8, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PDK1, PHKA2, PI3, PIK3CB, PLD1, PLD2, PLD3, PRKCM, PTK2, RDX, ROCK1, ROCK2, SERPINA4, SRF, TBXA2R 34 AKT1(4), AKT2(8), AKT3(3), ARHGEF11(20), BCL2(2), CDC42(2), DLG4(6), GNA13(1), LPA(55), MAP2K4(4), MAP3K1(4), MAP3K5(23), MAPK8(1), NFKB1(6), NFKB2(3), NFKBIA(2), NFKBIB(1), NFKBIL1(3), PDK1(2), PHKA2(9), PI3(6), PIK3CB(14), PLD1(13), PLD2(8), PLD3(1), PTK2(7), RDX(3), ROCK1(7), ROCK2(11), SERPINA4(20), SRF(3), TBXA2R(4) 19985802 256 124 242 136 145 22 10 41 38 0 0.675 1.000 1.000 198 TCRPATHWAY T cell receptors bind to foreign peptides presented by MHC molecules and induce T cell activation. CALM1, CALM2, CALM3, CD3D, CD3E, CD3G, CD3Z, ELK1, FOS, FYN, GRB2, HRAS, JUN, LAT, LCK, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKBIA, PIK3CA, PIK3R1, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, PTPN7, RAC1, RAF1, RASA1, RELA, SHC1, SOS1, SYT1, TRA@, TRB@, VAV1, ZAP70 41 CALM1(1), CALM2(1), CD3D(7), CD3E(2), CD3G(1), ELK1(3), FOS(2), FYN(7), GRB2(2), HRAS(3), JUN(1), LAT(2), LCK(15), MAP2K1(14), MAP2K4(4), MAP3K1(4), MAPK3(4), MAPK8(1), NFATC1(16), NFATC2(11), NFATC3(10), NFATC4(17), NFKB1(6), NFKBIA(2), PIK3CA(10), PIK3R1(2), PLCG1(8), PPP3CA(5), PPP3CB(3), PPP3CC(2), PRKCA(8), PTPN7(3), RAF1(10), RASA1(4), RELA(4), SHC1(2), SOS1(10), SYT1(23), VAV1(19), ZAP70(7) 19305047 256 124 242 116 155 25 11 32 32 1 0.290 1.000 1.000 199 APOPTOSIS APAF1, BAD, BAK1, BCL2L7P1, BAX, BCL2, BCL2L1, BCL2L11, BID, BIRC2, BIRC3, BIRC4, BIRC5, BNIP3L, CASP1, CASP10, CASP1, COPl, CASP2, CASP3, CASP4, CASP6, CASP7, CASP8, CASP9, CHUK, CYCS, DFFA, DFFB, FADD, FAS, FASLG, GZMB, HELLS, HRK, IKBKB, IKBKG, IRF1, IRF2, IRF3, IRF4, IRF5, IRF6, IRF7, JUN, LTA, MAP2K4, MAP3K1, MAPK10, MDM2, MYC, NFKB1, NFKBIA, NFKBIB, NFKBIE, PRF1, RELA, RIPK1, TNF, TNFRSF10B, TNFRSF1A, TNFRSF1B, TNFRSF21, TNFRSF25, TNFRSF25, PLEKHG5, TNFSF10, TP53, TP73, TRADD, TRAF1, TRAF2, TRAF3 65 APAF1(6), BAK1(1), BAX(3), BCL2(2), BCL2L11(5), BIRC2(6), BIRC3(7), BIRC5(1), BNIP3L(2), CASP1(10), CASP10(6), CASP2(1), CASP3(2), CASP4(2), CASP7(4), CASP8(9), CASP9(2), CHUK(2), CYCS(1), DFFA(2), DFFB(2), FAS(6), FASLG(15), GZMB(3), HELLS(5), IKBKB(4), IRF1(1), IRF2(6), IRF3(3), IRF4(2), IRF5(5), IRF6(15), IRF7(5), JUN(1), LTA(4), MAP2K4(4), MAP3K1(4), MAPK10(9), MDM2(1), MYC(5), NFKB1(6), NFKBIA(2), NFKBIB(1), PLEKHG5(11), PRF1(11), RELA(4), RIPK1(3), TNF(1), TNFRSF10B(4), TNFRSF1A(4), TNFRSF1B(4), TNFRSF21(11), TNFRSF25(6), TNFSF10(8), TP73(6), TRAF1(6), TRAF2(2), TRAF3(5) 23002255 269 123 264 143 176 25 13 23 32 0 0.411 1.000 1.000 200 HSA00310_LYSINE_DEGRADATION Genes involved in lysine degradation AADAT, AASDHPPT, AASS, ACAT1, ACAT2, AKR1B10, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, BBOX1, DLST, DOT1L, ECHS1, EHHADH, EHMT1, EHMT2, GCDH, HADH, HADHA, HSD17B10, HSD17B4, HSD3B7, NSD1, OGDH, OGDHL, PIPOX, PLOD1, PLOD2, PLOD3, RDH11, RDH12, RDH13, RDH14, SETD1A, SETD7, SETDB1, SHMT1, SHMT2, SPCS1, SPCS3, SUV39H1, SUV39H2, TMLHE 47 AADAT(5), AASDHPPT(3), AASS(3), ACAT2(1), AKR1B10(9), ALDH1A3(2), ALDH1B1(11), ALDH2(7), ALDH3A1(8), ALDH3A2(3), ALDH7A1(9), ALDH9A1(2), BBOX1(6), DOT1L(9), ECHS1(3), EHHADH(6), EHMT1(10), EHMT2(11), GCDH(6), HADH(2), HADHA(6), HSD17B10(2), HSD17B4(6), HSD3B7(5), NSD1(21), OGDH(8), OGDHL(42), PIPOX(6), PLOD1(5), PLOD2(6), PLOD3(4), RDH11(1), RDH12(2), RDH13(3), SETD1A(23), SETD7(1), SETDB1(11), SHMT1(2), SHMT2(3), SUV39H1(1), SUV39H2(2), TMLHE(2) 23608151 278 123 267 131 176 23 16 36 27 0 0.0773 1.000 1.000 201 HSA00340_HISTIDINE_METABOLISM Genes involved in histidine metabolism ABP1, ACY3, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH7A1, ALDH9A1, AMDHD1, AOC2, AOC3, ASPA, CARM1, CNDP1, DDC, FTCD, HAL, HARS, HARS2, HDC, HEMK1, HNMT, LCMT1, LCMT2, MAOA, MAOB, METTL2B, METTL6, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, PRPS1, PRPS2, UROC1, WBSCR22 41 ABP1(22), ACY3(4), ALDH1A3(2), ALDH1B1(11), ALDH2(7), ALDH3A1(8), ALDH3A2(3), ALDH3B1(3), ALDH3B2(8), ALDH7A1(9), ALDH9A1(2), AMDHD1(5), AOC2(9), AOC3(10), ASPA(3), CARM1(4), CNDP1(8), DDC(14), FTCD(3), HAL(14), HARS(6), HARS2(4), HDC(24), HEMK1(4), HNMT(2), LCMT1(4), LCMT2(1), MAOA(4), MAOB(13), METTL2B(7), METTL6(1), PRMT2(2), PRMT3(5), PRMT5(7), PRMT7(3), PRMT8(11), PRPS1(2), PRPS2(2), UROC1(14), WBSCR22(1) 16125644 266 123 257 165 169 24 19 21 32 1 0.471 1.000 1.000 202 HSA00790_FOLATE_BIOSYNTHESIS Genes involved in folate biosynthesis ALPI, ALPL, ALPP, ALPPL2, ASCC3, ASCC3L1, ATP13A2, DDX18, DDX19A, DDX23, DDX4, DDX41, DDX47, DDX50, DDX51, DDX52, DDX54, DDX55, DDX56, DHFR, DHX58, ENTPD7, EP400, ERCC2, ERCC3, FPGS, GCH1, GGH, IFIH1, MOV10L1, NUDT5, NUDT8, PTS, QDPR, RAD54B, RAD54L, RUVBL2, SETX, SKIV2L2, SMARCA2, SMARCA5, SPR 41 ALPI(9), ALPL(11), ALPP(10), ALPPL2(12), ASCC3(13), ATP13A2(12), DDX18(5), DDX23(6), DDX4(12), DDX41(7), DDX47(1), DDX50(4), DDX51(5), DDX52(4), DDX54(3), DDX55(2), DDX56(3), DHFR(2), DHX58(4), ENTPD7(2), EP400(27), ERCC2(3), ERCC3(6), FPGS(3), GGH(3), IFIH1(12), MOV10L1(25), NUDT5(1), NUDT8(2), QDPR(3), RAD54B(8), RUVBL2(5), SETX(19), SKIV2L2(6), SMARCA2(14), SMARCA5(5), SPR(4) 25472673 273 123 262 143 174 16 17 28 38 0 0.453 1.000 1.000 203 COMPPATHWAY Both the classic and alternative immune complement pathways promote inflammation, foreign cell lysis, and phagocytosis. BF, C1QA, C1QB, C1QG, C1R, C1S, C2, C3, C4A, C4B, C5, C6, C7, C8A, C9, DF, MASP1, MASP2, MBL2 13 C1QA(6), C1QB(7), C1R(16), C1S(20), C3(48), C5(21), C6(72), C7(47), C9(22), MASP1(10), MASP2(11), MBL2(13) 8129948 293 122 266 124 220 12 6 25 28 2 0.00416 1.000 1.000 204 HSA00190_OXIDATIVE_PHOSPHORYLATION Genes involved in oxidative phosphorylation ATP12A, ATP4A, ATP4B, ATP5A1, ATP5B, ATP5C1, ATP5D, ATP5E, ATP5F1, ATP5G1, ATP5G2, ATP5G3, ATP5H, ATP5I, ATP5J, ATP5J2, ATP5L, ATP5O, ATP6, ATP6AP1, ATP6V0A1, ATP6V0A2, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0D1, ATP6V0D2, ATP6V0E1, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1E2, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, ATP8, COX1, COX10, COX15, COX17, COX2, COX3, COX4I1, COX4I2, COX5A, COX5B, COX6A1, COX6A2, COX6B1, COX6B2, COX6C, COX7A1, COX7A2, COX7B, COX7B2, COX7C, COX8A, COX8C, CYC1, CYTB, LHPP, ND1, ND2, ND3, ND4, ND4L, ND5, ND6, NDUFA1, NDUFA10, NDUFA11, NDUFA12, NDUFA13, NDUFA2, NDUFA3, NDUFA4, NDUFA4L2, NDUFA5, NDUFA6, NDUFA7, NDUFA8, NDUFA9, NDUFAB1, NDUFB1, NDUFB10, NDUFB11, NDUFB2, NDUFB3, NDUFB4, NDUFB5, NDUFB6, NDUFB7, NDUFB8, NDUFB9, NDUFC1, NDUFC2, NDUFS1, NDUFS2, NDUFS3, NDUFS4, NDUFS5, NDUFS6, NDUFS7, NDUFS8, NDUFV1, NDUFV2, NDUFV3, PPA1, PPA2, SDHA, SDHB, SDHC, SDHD, TCIRG1, UCRC, UQCR, UQCRB, UQCRC1, UQCRC2, UQCRFS1, UQCRH, UQCRQ 112 ATP12A(27), ATP4A(16), ATP4B(1), ATP5A1(1), ATP5B(1), ATP5C1(3), ATP5F1(7), ATP5G2(3), ATP5H(3), ATP5J(2), ATP6AP1(3), ATP6V0A1(12), ATP6V0A2(5), ATP6V0A4(22), ATP6V0D1(1), ATP6V0D2(10), ATP6V0E1(1), ATP6V1A(2), ATP6V1B1(4), ATP6V1B2(3), ATP6V1C1(1), ATP6V1C2(7), ATP6V1E1(1), ATP6V1E2(3), ATP6V1F(1), ATP6V1G2(1), ATP6V1G3(7), ATP6V1H(5), COX10(6), COX15(3), COX4I2(4), COX5B(1), COX6A1(1), COX6B1(2), COX6C(1), COX7B(1), COX7B2(3), COX8A(1), COX8C(2), CYC1(4), LHPP(1), NDUFA10(4), NDUFA4(1), NDUFA9(2), NDUFAB1(1), NDUFB2(2), NDUFB3(1), NDUFB5(3), NDUFB6(2), NDUFB7(2), NDUFS1(2), NDUFS2(3), NDUFS3(5), NDUFS4(3), NDUFS5(1), NDUFS6(2), NDUFS7(3), NDUFS8(3), NDUFV1(3), NDUFV2(1), NDUFV3(3), PPA1(1), PPA2(4), SDHA(3), SDHC(3), SDHD(1), TCIRG1(5), UQCRC1(4), UQCRC2(3), UQCRFS1(2) 22704441 256 122 250 125 152 22 13 38 30 1 0.127 1.000 1.000 205 HSA00280_VALINE_LEUCINE_AND_ISOLEUCINE_DEGRADATION Genes involved in valine, leucine and isoleucine degradation ABAT, ACAA1, ACAA2, ACADM, ACADS, ACAT1, ACAT2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH7A1, ALDH9A1, AOX1, AUH, BCAT1, BCAT2, BCKDHA, BCKDHB, DBT, DLD, ECHS1, EHHADH, HADH, HADHA, HADHB, HIBADH, HIBCH, HMGCL, HMGCS1, HMGCS2, HSD17B10, HSD17B4, IVD, MCCC1, MCCC2, MCEE, MUT, OXCT1, OXCT2, PCCA, PCCB 44 ABAT(9), ACAA1(6), ACAA2(1), ACADM(4), ACADS(5), ACAT2(1), ALDH1A3(2), ALDH1B1(11), ALDH2(7), ALDH3A1(8), ALDH3A2(3), ALDH6A1(4), ALDH7A1(9), ALDH9A1(2), AOX1(26), AUH(1), BCAT1(13), BCAT2(1), BCKDHA(2), BCKDHB(2), DBT(3), DLD(3), ECHS1(3), EHHADH(6), HADH(2), HADHA(6), HADHB(5), HIBADH(7), HIBCH(1), HMGCL(4), HMGCS1(3), HMGCS2(21), HSD17B10(2), HSD17B4(6), IVD(5), MCCC1(5), MCCC2(3), MCEE(2), MUT(6), OXCT1(4), OXCT2(5), PCCA(4), PCCB(3) 17616112 226 121 216 101 139 18 16 28 25 0 0.146 1.000 1.000 206 HSA04740_OLFACTORY_TRANSDUCTION Genes involved in olfactory transduction ADCY3, ADRBK2, ARRB2, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CLCA1, CLCA2, CLCA4, CNGA3, CNGA4, CNGB1, GNAL, GUCA1A, GUCA1B, GUCA1C, PDC, PDE1C, PRKACA, PRKACB, PRKACG, PRKG1, PRKG2, PRKX, PRKY 30 ADCY3(3), ADRBK2(6), ARRB2(6), CALM1(1), CALM2(1), CALML3(9), CALML6(1), CAMK2A(6), CAMK2B(6), CAMK2D(6), CAMK2G(5), CLCA1(6), CLCA2(10), CLCA4(29), CNGA3(26), CNGA4(18), CNGB1(21), GNAL(2), GUCA1A(6), GUCA1B(2), GUCA1C(7), PDC(6), PDE1C(52), PRKACA(3), PRKACB(4), PRKACG(11), PRKG1(14), PRKG2(16), PRKX(3) 12329451 286 121 267 154 193 22 9 29 33 0 0.122 1.000 1.000 207 HSA00330_ARGININE_AND_PROLINE_METABOLISM Genes involved in arginine and proline metabolism ALDH4A1, ARG1, ARG2, ASL, ASS1, CKB, CKM, CKMT1A, CKMT1B, CKMT2, CPS1, DAO, EPRS, GAMT, GATM, GLUD1, GLUD2, GOT1, GOT2, LAP3, NOS1, NOS2A, NOS3, OAT, OTC, P4HA1, P4HA2, P4HA3, PARS2, PRODH, PYCR1, PYCR2, PYCRL, RARS, RARS2 34 ALDH4A1(6), ARG1(2), ARG2(2), ASL(6), ASS1(8), CKM(3), CKMT1A(1), CKMT2(5), CPS1(26), DAO(11), EPRS(13), GAMT(4), GATM(6), GLUD1(2), GLUD2(4), GOT1(6), GOT2(6), LAP3(1), NOS1(74), NOS3(19), OAT(4), OTC(4), P4HA1(10), P4HA2(6), P4HA3(12), PRODH(2), PYCR1(1), PYCR2(2), RARS(7), RARS2(5) 14615642 258 120 244 130 172 26 10 18 32 0 0.0738 1.000 1.000 208 MONOAMINE_GPCRS ADRA1A, ADRA1B, ADRA1D, ADRA2A, ADRA2C, ADRB1, ADRB2, ADRB3, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, DRD1, DRD2, DRD3, DRD4, DRD5, HRH1, HRH2, HTR1A, HTR1B, HTR1D, HTR1E, HTR1F, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, HTR7, LOC93164 32 ADRA1A(9), ADRA1B(4), ADRA1D(5), ADRA2A(3), ADRA2C(2), ADRB1(5), ADRB2(3), CHRM1(5), CHRM2(25), CHRM3(26), CHRM4(6), CHRM5(7), DRD1(9), DRD2(14), DRD3(6), DRD4(1), DRD5(25), HRH1(14), HRH2(3), HTR1A(10), HTR1B(1), HTR1D(6), HTR1E(7), HTR1F(9), HTR2A(11), HTR2B(2), HTR2C(13), HTR4(9), HTR5A(19), HTR6(1), HTR7(9) 10319864 269 120 247 208 174 33 9 26 27 0 0.101 1.000 1.000 209 PYRUVATE_METABOLISM ACACA, ACAS2, ACAS2L, ACAT1, ACAT2, ACYP1, ACYP2, ADH5, AKR1B1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, CACH_1, DLAT, DLD, GLO1, GRHPR, HAGH, HAGHL, LDHA, LDHB, LDHC, LDHD, MDH1, MDH2, ME1, ME2, ME3, PC, PCK1, PDHA1, PDHA2, PDHB, PKLR, PKM2 37 ACACA(20), ACAT2(1), ACYP1(1), ADH5(3), AKR1B1(2), ALDH1A1(5), ALDH1A2(14), ALDH1A3(2), ALDH1B1(11), ALDH2(7), ALDH3A1(8), ALDH3A2(3), ALDH9A1(2), DLAT(4), DLD(3), GLO1(1), GRHPR(1), HAGH(2), LDHA(4), LDHB(2), LDHC(5), LDHD(1), MDH1(3), MDH2(3), ME1(20), ME2(2), ME3(8), PC(14), PCK1(25), PDHA1(4), PDHA2(20), PDHB(1), PKLR(13), PKM2(7) 15114468 222 120 215 119 146 16 12 24 23 1 0.353 1.000 1.000 210 SA_B_CELL_RECEPTOR_COMPLEXES Antigen binding to B cell receptors activates protein tyrosine kinases, such as the Src family, which ultimate activate MAP kinases. ATF2, BCR, BLNK, ELK1, FOS, GRB2, HRAS, JUN, LYN, MAP2K1, MAP3K1, MAPK1, MAPK3, MAPK8IP3, PAPPA, RAC1, RPS6KA1, RPS6KA3, SHC1, SOS1, SYK, VAV1, VAV2, VAV3 23 ATF2(6), BCR(15), BLNK(15), ELK1(3), FOS(2), GRB2(2), HRAS(3), JUN(1), LYN(10), MAP2K1(14), MAP3K1(4), MAPK1(4), MAPK3(4), MAPK8IP3(10), PAPPA(59), RPS6KA1(8), RPS6KA3(1), SHC1(2), SOS1(10), SYK(14), VAV1(19), VAV2(3), VAV3(14) 12818866 223 120 207 135 147 18 4 22 31 1 0.851 1.000 1.000 211 BILE_ACID_BIOSYNTHESIS ACAA1, ACAA2, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AKR1C4, AKR1D1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, BAAT, CEL, CYP27A1, CYP7A1, HADHB, SOAT2, SRD5A1, SRD5A2 27 ACAA1(6), ACAA2(1), ADH1A(17), ADH1B(30), ADH1C(1), ADH4(10), ADH6(14), ADH7(16), ADHFE1(6), AKR1C4(10), AKR1D1(19), ALDH1A1(5), ALDH1A2(14), ALDH1A3(2), ALDH1B1(11), ALDH2(7), ALDH3A1(8), ALDH3A2(3), ALDH9A1(2), BAAT(13), CEL(13), CYP27A1(3), CYP7A1(8), HADHB(5), SOAT2(5), SRD5A1(2), SRD5A2(6) 9512796 237 119 212 100 157 19 15 22 24 0 0.00211 1.000 1.000 212 INTEGRINPATHWAY Integrins are cell surface receptors commonly present at focal adhensions that interact with the extracellular matrix and transduce extracellular signaling. ACTA1, ACTN1, ACTN2, ACTN3, ARHA, BCAR1, BCR, CAPN1, CAPNS1, CAPNS2, CAV1, CRKL, CSK, FYN, GRB2, GRF2, HRAS, ITGA1, ITGB1, JUN, MAP2K1, MAP2K2, MAPK1, MAPK3, MAPK8, PPP1R12B, PTK2, PXN, RAF1, RAP1A, ROCK1, SHC1, SOS1, SRC, TLN1, TNS, VCL, ZYX 35 ACTA1(4), ACTN1(8), ACTN2(20), ACTN3(3), BCAR1(5), BCR(15), CAPN1(4), CAPNS1(3), CAPNS2(1), CAV1(1), CRKL(3), CSK(1), FYN(7), GRB2(2), HRAS(3), ITGA1(24), ITGB1(4), JUN(1), MAP2K1(14), MAP2K2(5), MAPK1(4), MAPK3(4), MAPK8(1), PPP1R12B(7), PTK2(7), PXN(2), RAF1(10), RAP1A(2), ROCK1(7), SHC1(2), SOS1(10), SRC(2), TLN1(12), VCL(8), ZYX(8) 19047653 214 119 204 99 114 24 12 35 28 1 0.114 1.000 1.000 213 KERATINOCYTEPATHWAY Keratinocyte differentiation, which models the differentiation of epidermal cells, requires the four main MAP kinase pathways. BCL2, CEBPA, CHUK, DAXX, EGF, EGFR, ETS1, ETS2, FOS, HOXA7, HRAS, IKBKB, JUN, MAP2K1, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAP3K1, MAP3K14, MAP3K5, MAPK1, MAPK13, MAPK14, MAPK3, MAPK8, NFKB1, NFKBIA, PPP2CA, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCQ, RAF1, RELA, RIPK1, SP1, TNF, TNFRSF1A, TNFRSF1B, TNFRSF6, TNFSF6, TRAF2 42 BCL2(2), CHUK(2), DAXX(9), EGF(21), EGFR(25), ETS1(4), ETS2(8), FOS(2), HOXA7(2), HRAS(3), IKBKB(4), JUN(1), MAP2K1(14), MAP2K3(8), MAP2K4(4), MAP2K6(3), MAP2K7(5), MAP3K1(4), MAP3K14(6), MAP3K5(23), MAPK1(4), MAPK13(5), MAPK14(5), MAPK3(4), MAPK8(1), NFKB1(6), NFKBIA(2), PRKCA(8), PRKCD(5), PRKCE(6), PRKCG(16), PRKCH(9), PRKCQ(20), RAF1(10), RELA(4), RIPK1(3), SP1(5), TNF(1), TNFRSF1A(4), TNFRSF1B(4), TRAF2(2) 19977441 274 118 262 159 161 25 8 37 43 0 0.733 1.000 1.000 214 ERKPATHWAY Cell growth is promoted by Ras activation of the anti-apoptotic p44/42 MAP kinase pathway. DPM2, EGFR, ELK1, GNAS, GNB1, GNGT1, GRB2, HRAS, IGF1R, ITGB1, KLK2, MAP2K1, MAP2K2, MAPK1, MAPK3, MKNK1, MKNK2, MYC, NGFB, NGFR, PDGFRA, PPP2CA, PTPRR, RAF1, RPS6KA1, RPS6KA5, SHC1, SOS1, SRC, STAT3 29 DPM2(1), EGFR(25), ELK1(3), GNAS(25), GNB1(1), GRB2(2), HRAS(3), IGF1R(14), ITGB1(4), KLK2(5), MAP2K1(14), MAP2K2(5), MAPK1(4), MAPK3(4), MKNK1(6), MKNK2(3), MYC(5), NGFR(8), PDGFRA(34), PTPRR(30), RAF1(10), RPS6KA1(8), RPS6KA5(7), SHC1(2), SOS1(10), SRC(2), STAT3(9) 13436463 244 117 228 111 149 25 11 41 18 0 0.122 1.000 1.000 215 GPCRPATHWAY G-protein coupled receptors activate adenylyl cyclase, which converts ATP to cAMP, to activate second messenger pathways. ADCY1, CALM1, CALM2, CALM3, CREB1, ELK1, FOS, GNAI1, GNAQ, GNAS, GNB1, GNGT1, HRAS, JUN, MAP2K1, MAPK3, NFATC1, NFATC2, NFATC3, NFATC4, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, RAF1, RPS6KA3, SYT1 34 ADCY1(34), CALM1(1), CALM2(1), ELK1(3), FOS(2), GNAI1(2), GNAQ(6), GNAS(25), GNB1(1), HRAS(3), JUN(1), MAP2K1(14), MAPK3(4), NFATC1(16), NFATC2(11), NFATC3(10), NFATC4(17), PLCG1(8), PPP3CA(5), PPP3CB(3), PPP3CC(2), PRKACB(4), PRKACG(11), PRKAR1A(3), PRKAR1B(4), PRKAR2A(1), PRKAR2B(5), PRKCA(8), RAF1(10), RPS6KA3(1), SYT1(23) 14201029 239 117 222 127 145 25 14 28 27 0 0.617 1.000 1.000 216 HSA01031_GLYCAN_STRUCTURES_BIOSYNTHESIS_2 Genes involved in glycan structures - biosynthesis 2 A4GALT, ABO, B3GALNT1, B3GALT1, B3GALT2, B3GALT4, B3GALT5, B3GNT1, B3GNT2, B3GNT3, B3GNT4, B3GNT5, B4GALNT1, B4GALT1, B4GALT2, B4GALT3, B4GALT4, B4GALT6, FUT1, FUT2, FUT3, FUT4, FUT5, FUT6, FUT7, FUT9, GBGT1, GCNT2, PIGA, PIGB, PIGC, PIGF, PIGG, PIGH, PIGK, PIGL, PIGM, PIGN, PIGO, PIGP, PIGQ, PIGS, PIGT, PIGU, PIGV, PIGX, PIGZ, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4, ST3GAL5, ST3GAL6, ST6GALNAC3, ST6GALNAC4, ST6GALNAC5, ST6GALNAC6, ST8SIA1, ST8SIA5, UGCG, UGCGL1, UGCGL2 59 A4GALT(7), ABO(5), B3GALNT1(6), B3GALT1(14), B3GALT2(1), B3GALT4(2), B3GALT5(1), B3GNT1(3), B3GNT2(2), B3GNT3(7), B3GNT4(4), B3GNT5(2), B4GALNT1(5), B4GALT1(2), B4GALT2(2), B4GALT3(2), B4GALT4(3), B4GALT6(2), FUT1(3), FUT2(3), FUT3(8), FUT4(4), FUT5(8), FUT6(4), FUT7(2), PIGA(1), PIGB(3), PIGC(2), PIGF(2), PIGG(9), PIGH(2), PIGK(7), PIGL(3), PIGM(1), PIGN(3), PIGO(12), PIGQ(9), PIGS(1), PIGT(1), PIGU(7), PIGV(8), PIGX(2), PIGZ(3), ST3GAL1(7), ST3GAL2(1), ST3GAL3(2), ST3GAL4(2), ST3GAL5(2), ST3GAL6(2), ST6GALNAC3(6), ST6GALNAC4(4), ST6GALNAC5(10), ST6GALNAC6(1), ST8SIA1(1), ST8SIA5(10), UGCG(1) 19457481 227 117 224 130 129 24 11 36 27 0 0.389 1.000 1.000 217 CLASSICPATHWAY The classic complement pathway is initiated by antibodies and promotes phagocytosis and lysis of foreign cells as well as activating the inflammatory response. C1QA, C1QB, C1QG, C1R, C1S, C2, C3, C4A, C4B, C5, C6, C7, C8A, C9 10 C1QA(6), C1QB(7), C1R(16), C1S(20), C3(48), C5(21), C6(72), C7(47), C9(22) 6578372 259 116 234 109 193 10 5 24 25 2 0.00857 1.000 1.000 218 HIVNEFPATHWAY HIV-infected CD4 helper T cells may express Fas ligand, which binds to the Fas receptors of uninfected cells and induces apoptosis. ACTG1, ADPRT, APAF1, ARHGDIB, BAG4, BCL2, BID, BIRC2, BIRC3, BIRC4, CASP2, CASP3, CASP6, CASP7, CASP8, CASP9, CDC2L1, CDC2L2, CFLAR, CHUK, CRADD, CYCS, DAXX, DFFA, DFFB, FADD, GSN, LMNA, LMNB1, LMNB2, MAP2K7, MAP3K1, MAP3K14, MAP3K5, MAPK8, MDM2, NFKB1, NFKBIA, NUMA1, PAK2, PRKCD, PRKDC, PSEN1, PSEN2, PTK2, RASA1, RB1, RELA, RIPK1, SPTAN1, TNF, TNFRSF1A, TNFRSF1B, TNFRSF6, TNFSF6, TRADD, TRAF1, TRAF2 52 ACTG1(6), APAF1(6), ARHGDIB(4), BAG4(3), BCL2(2), BIRC2(6), BIRC3(7), CASP2(1), CASP3(2), CASP7(4), CASP8(9), CASP9(2), CFLAR(4), CHUK(2), CRADD(2), CYCS(1), DAXX(9), DFFA(2), DFFB(2), GSN(6), LMNA(7), LMNB1(1), LMNB2(4), MAP2K7(5), MAP3K1(4), MAP3K14(6), MAP3K5(23), MAPK8(1), MDM2(1), NFKB1(6), NFKBIA(2), NUMA1(9), PAK2(7), PRKCD(5), PRKDC(19), PSEN1(1), PSEN2(2), PTK2(7), RASA1(4), RB1(10), RELA(4), RIPK1(3), SPTAN1(10), TNF(1), TNFRSF1A(4), TNFRSF1B(4), TRAF1(6), TRAF2(2) 28184909 238 116 232 123 123 25 15 36 37 2 0.523 1.000 1.000 219 ALKPATHWAY Activin receptor-like kinase 3 (ALK3) is required during gestation for cardiac muscle development. ACVR1, APC, ATF2, AXIN1, BMP10, BMP2, BMP4, BMP5, BMP7, BMPR1A, BMPR2, CHRD, CTNNB1, DVL1, FZD1, GATA4, GSK3B, MADH1, MADH4, MADH5, MADH6, MAP3K7, MEF2C, MYL2, NKX2-5, NOG, NPPA, NPPB, RFC1, TCF1, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TGFBR3, WNT1 32 ACVR1(2), APC(25), ATF2(6), AXIN1(9), BMP10(14), BMP2(7), BMP4(4), BMP5(32), BMP7(5), BMPR1A(2), BMPR2(6), CHRD(21), CTNNB1(14), FZD1(5), GATA4(4), GSK3B(3), MAP3K7(1), MEF2C(4), MYL2(9), NKX2-5(1), NOG(2), NPPA(4), NPPB(6), RFC1(5), TGFB1(2), TGFB2(3), TGFB3(3), TGFBR2(9), TGFBR3(8), WNT1(2) 14781382 218 115 201 96 140 18 9 20 31 0 0.186 1.000 1.000 220 HSA00600_SPHINGOLIPID_METABOLISM Genes involved in sphingolipid metabolism ARSA, ARSD, ARSE, ASAH1, ASAH3L, B4GALT6, CERK, DEGS1, DEGS2, ENPP7, FVT1, GAL3ST1, GALC, GBA, GLA, GLB1, LCT, NEU1, NEU2, NEU3, NEU4, PHCA, PPAP2A, PPAP2B, PPAP2C, SGMS1, SGMS2, SGPP1, SGPP2, SMPD1, SMPD2, SMPD3, SMPD4, SPHK1, SPHK2, SPTLC1, SPTLC2, UGCG, UGT8 36 ARSD(3), ARSE(5), B4GALT6(2), CERK(1), DEGS1(2), DEGS2(6), ENPP7(7), GAL3ST1(10), GALC(3), GBA(7), GLA(2), GLB1(9), LCT(51), NEU1(6), NEU2(17), NEU3(4), NEU4(16), PPAP2A(1), PPAP2B(11), PPAP2C(8), SGMS1(18), SGMS2(1), SGPP1(2), SGPP2(6), SMPD1(2), SMPD2(2), SMPD3(9), SMPD4(5), SPHK1(2), SPHK2(7), SPTLC1(1), SPTLC2(6), UGCG(1), UGT8(8) 14474950 241 115 234 145 168 15 6 28 24 0 0.587 1.000 1.000 221 HSA01032_GLYCAN_STRUCTURES_DEGRADATION Genes involved in degradation of glycan structures AGA, ARSB, FLJ21865, FUCA1, FUCA2, GALNS, GBA, GLB1, GNS, GUSB, HEXA, HEXB, HGSNAT, HPSE, HPSE2, HYAL1, HYAL2, IDS, IDUA, LCT, MAN2B1, MAN2B2, MAN2C1, MANBA, NAGLU, NEU1, NEU2, NEU3, NEU4, SPAM1 29 AGA(4), ARSB(2), FUCA1(3), GALNS(5), GBA(7), GLB1(9), GNS(1), GUSB(5), HEXA(6), HEXB(4), HGSNAT(5), HPSE(10), HPSE2(5), HYAL1(2), HYAL2(1), IDS(9), IDUA(4), LCT(51), MAN2B1(8), MAN2B2(10), MAN2C1(7), MANBA(8), NAGLU(4), NEU1(6), NEU2(17), NEU3(4), NEU4(16), SPAM1(27) 13947871 240 115 236 112 169 19 5 23 24 0 0.0340 1.000 1.000 222 RAC1PATHWAY Rac-1 is a Rho family G protein that stimulates formation of actin-dependent structures such as filopodia and lamellopodia. ARFIP2, CDK5, CDK5R1, CFL1, CHN1, LIMK1, MAP3K1, MYL2, MYLK, NCF2, PAK1, PDGFRA, PIK3CA, PIK3R1, PLD1, PPP1R12B, RAC1, RALBP1, RPS6KB1, TRIO, VAV1, WASF1 21 ARFIP2(2), CDK5(6), CDK5R1(1), CFL1(2), CHN1(7), LIMK1(5), MAP3K1(4), MYL2(9), MYLK(46), NCF2(9), PAK1(4), PDGFRA(34), PIK3CA(10), PIK3R1(2), PLD1(13), PPP1R12B(7), RALBP1(3), RPS6KB1(3), TRIO(23), VAV1(19), WASF1(4) 14117435 213 115 203 113 134 13 10 25 30 1 0.550 1.000 1.000 223 GLYCINE_SERINE_AND_THREONINE_METABOLISM ABP1, AGXT, AGXT2, ALAS1, ALAS2, AMT, AOC2, AOC3, ATP6V0C, SHMT1, BHMT, CBS, CHDH, CHKA, CHKB, CHKB, CPT1B, CTH, DAO, DLD, DMGDH, GAMT, GARS, GATM, GCAT, GLDC, MAOA, MAOB, PEMT, PISD, PLCB2, PLCG1, PLCG2, PSPH, SARDH, SARS, SHMT1, SHMT2, TARS 36 ABP1(22), AGXT(10), ALAS1(2), ALAS2(5), AMT(1), AOC2(9), AOC3(10), BHMT(8), CBS(7), CHDH(8), CHKA(2), CHKB(3), CPT1B(8), CTH(1), DAO(11), DLD(3), DMGDH(15), GAMT(4), GARS(6), GATM(6), GCAT(4), GLDC(5), MAOA(4), MAOB(13), PEMT(2), PISD(2), PLCB2(12), PLCG1(8), PLCG2(27), PSPH(2), SARDH(20), SARS(5), SHMT1(2), SHMT2(3), TARS(5) 16733161 255 114 248 157 173 17 14 18 33 0 0.412 1.000 1.000 224 PHENYLALANINE_METABOLISM ABP1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, DDC, EPX, GOT1, GOT2, HPD, LPO, MAOA, MAOB, MPO, PRDX1, PRDX2, PRDX5, PRDX6, TAT, TPO 22 ABP1(22), ALDH1A3(2), ALDH3A1(8), ALDH3B1(3), ALDH3B2(8), AOC2(9), AOC3(10), DDC(14), EPX(9), GOT1(6), GOT2(6), HPD(7), LPO(20), MAOA(4), MAOB(13), MPO(11), PRDX1(3), PRDX2(3), PRDX6(4), TAT(19), TPO(47) 8944506 228 114 221 140 160 19 10 13 26 0 0.164 1.000 1.000 225 SPPAPATHWAY Thrombin cleaves protease-activated receptors PAR1 and PAR4 to induce calcium influx and activate platelet aggregation, a process inhibited by aspirin. F2, F2R, F2RL3, GNAI1, GNB1, GNGT1, HRAS, ITGA1, ITGB1, MAP2K1, MAPK1, MAPK3, PLA2G4A, PLCB1, PRKCA, PRKCB1, PTGS1, PTK2, RAF1, SRC, SYK, TBXAS1 21 F2(11), F2R(8), F2RL3(4), GNAI1(2), GNB1(1), HRAS(3), ITGA1(24), ITGB1(4), MAP2K1(14), MAPK1(4), MAPK3(4), PLA2G4A(15), PLCB1(54), PRKCA(8), PTGS1(20), PTK2(7), RAF1(10), SRC(2), SYK(14), TBXAS1(16) 9931242 225 114 207 95 149 16 6 28 26 0 0.0265 1.000 1.000 226 VEGFPATHWAY Vascular endothelial growth factor (VEGF) is upregulated by hypoxic conditions and promotes normal blood vessel formation and angiogenesis related to tumor growth or cardiac disease. ARNT, EIF1, EIF1A, EIF2B1, EIF2B2, EIF2B3, EIF2B4, EIF2B5, EIF2S1, EIF2S2, EIF2S3, ELAVL1, FLT1, FLT4, HIF1A, HRAS, KDR, NOS3, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, PTK2, PXN, SHC1, VEGF, VHL 25 ARNT(9), EIF2B1(1), EIF2B2(1), EIF2B3(3), EIF2B4(1), EIF2B5(2), EIF2S1(1), EIF2S3(1), ELAVL1(1), FLT1(38), FLT4(30), HIF1A(4), HRAS(3), KDR(55), NOS3(19), PIK3CA(10), PIK3R1(2), PLCG1(8), PRKCA(8), PTK2(7), PXN(2), SHC1(2), VHL(4) 13929275 212 114 200 107 138 19 4 27 23 1 0.388 1.000 1.000 227 HSA00510_N_GLYCAN_BIOSYNTHESIS Genes involved in N-glycan biosynthesis ALG1, ALG10, ALG10B, ALG11, ALG12, ALG13, ALG14, ALG2, ALG3, ALG5, ALG6, ALG8, ALG9, B4GALT1, B4GALT2, B4GALT3, DAD1, DDOST, DHDDS, DOLPP1, DPAGT1, DPM1, FUT8, GANAB, GCS1, MAN1A1, MAN1A2, MAN1B1, MAN1C1, MAN2A1, MGAT1, MGAT2, MGAT3, MGAT4A, MGAT4B, MGAT5, MGAT5B, RFT1, RPN1, RPN2, ST6GAL1, STT3B 41 ALG1(3), ALG10(6), ALG10B(4), ALG12(1), ALG13(10), ALG14(2), ALG2(5), ALG3(4), ALG5(3), ALG6(2), ALG8(7), ALG9(6), B4GALT1(2), B4GALT2(2), B4GALT3(2), DAD1(1), DDOST(2), DHDDS(1), DOLPP1(3), DPAGT1(2), DPM1(1), FUT8(8), GANAB(5), MAN1A1(18), MAN1A2(7), MAN1B1(3), MAN1C1(11), MAN2A1(10), MGAT1(3), MGAT2(2), MGAT3(11), MGAT4A(8), MGAT4B(1), MGAT5(6), MGAT5B(12), RFT1(5), RPN2(4), ST6GAL1(6), STT3B(5) 17272697 194 113 189 99 115 20 13 20 26 0 0.200 1.000 1.000 228 TOLLPATHWAY Toll-like receptors are activated by bacterial lipoproteins, lipopolysaccharides, and other surface molecules, and activate pro-inflammatory factors such as NF-kB. CD14, CHUK, ELK1, FOS, IKBKB, IKBKG, IRAK1, JUN, LY96, MAP2K3, MAP2K4, MAP2K6, MAP3K1, MAP3K14, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAPK14, MAPK8, MYD88, NFKB1, NFKBIA, PGLYRP, PPARA, PRKR, RELA, SITPEC, TIRAP, TLR10, TLR2, TLR3, TLR4, TLR6, TLR7, TLR9, TOLLIP, TRAF6 31 CD14(5), CHUK(2), ELK1(3), FOS(2), IKBKB(4), IRAK1(5), JUN(1), LY96(4), MAP2K3(8), MAP2K4(4), MAP2K6(3), MAP3K1(4), MAP3K14(6), MAP3K7(1), MAPK14(5), MAPK8(1), MYD88(3), NFKB1(6), NFKBIA(2), PPARA(7), RELA(4), TIRAP(1), TLR10(12), TLR2(15), TLR3(11), TLR4(41), TLR6(7), TLR7(17), TLR9(18), TOLLIP(1), TRAF6(4) 14804084 207 113 200 104 136 21 10 22 18 0 0.216 1.000 1.000 229 GHPATHWAY Growth hormone receptors dimerize on ligand binding and activate the JAK2 protein kinase. GH1, GHR, GRB2, HRAS, INS, INSR, IRS1, JAK2, MAP2K1, MAPK1, MAPK3, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, PTPN6, RAF1, RPS6KA1, SHC1, SLC2A4, SOCS1, SOS1, SRF, STAT5A, STAT5B, TCF1 25 GH1(3), GHR(40), GRB2(2), HRAS(3), INSR(26), IRS1(5), JAK2(8), MAP2K1(14), MAPK1(4), MAPK3(4), PIK3CA(10), PIK3R1(2), PLCG1(8), PRKCA(8), PTPN6(5), RAF1(10), RPS6KA1(8), SHC1(2), SLC2A4(9), SOCS1(1), SOS1(10), SRF(3), STAT5A(3), STAT5B(6) 13541567 194 112 178 92 116 14 11 33 19 1 0.262 1.000 1.000 230 HSA00260_GLYCINE_SERINE_AND_THREONINE_METABOLISM Genes involved in glycine, serine and threonine metabolism ABP1, AGXT, AGXT2, AKR1B10, ALAS1, ALAS2, AMT, AOC2, AOC3, BHMT, CBS, CHDH, CHKA, CHKB, CTH, DAO, DLD, DMGDH, GAMT, GARS, GATM, GCAT, GLDC, GNMT, HSD3B7, MAOA, MAOB, PEMT, PHGDH, PIPOX, PISD, PSAT1, PSPH, RDH11, RDH12, RDH13, RDH14, SARDH, SARS, SARS2, SDS, SHMT1, SHMT2, TARS, TARS2 44 ABP1(22), AGXT(10), AKR1B10(9), ALAS1(2), ALAS2(5), AMT(1), AOC2(9), AOC3(10), BHMT(8), CBS(7), CHDH(8), CHKA(2), CHKB(3), CTH(1), DAO(11), DLD(3), DMGDH(15), GAMT(4), GARS(6), GATM(6), GCAT(4), GLDC(5), GNMT(1), HSD3B7(5), MAOA(4), MAOB(13), PEMT(2), PHGDH(12), PIPOX(6), PISD(2), PSAT1(3), PSPH(2), RDH11(1), RDH12(2), RDH13(3), SARDH(20), SARS(5), SARS2(4), SDS(2), SHMT1(2), SHMT2(3), TARS(5), TARS2(7) 17017074 255 112 246 155 170 17 12 19 37 0 0.500 1.000 1.000 231 HSA00360_PHENYLALANINE_METABOLISM Genes involved in phenylalanine metabolism ABP1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, ARD1A, DDC, EPX, ESCO1, ESCO2, GOT1, GOT2, HPD, LPO, LYCAT, MAOA, MAOB, MIF, MPO, MYST3, MYST4, NAT5, NAT6, PNPLA3, PRDX6, SH3GLB1, TAT, TPO 27 ABP1(22), ALDH1A3(2), ALDH3A1(8), ALDH3B1(3), ALDH3B2(8), AOC2(9), AOC3(10), DDC(14), EPX(9), ESCO1(2), ESCO2(4), GOT1(6), GOT2(6), HPD(7), LPO(20), MAOA(4), MAOB(13), MPO(11), PNPLA3(3), PRDX6(4), SH3GLB1(2), TAT(19), TPO(47) 13985816 233 112 226 148 162 18 13 15 25 0 0.723 1.000 1.000 232 HSA00903_LIMONENE_AND_PINENE_DEGRADATION Genes involved in limonene and pinene degradation ACOT11, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, ARD1A, CYP2C19, CYP2C9, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ECHS1, EHHADH, ESCO1, ESCO2, HADHA, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1, YOD1 26 ACOT11(10), ALDH1A3(2), ALDH1B1(11), ALDH2(7), ALDH3A1(8), ALDH3A2(3), ALDH7A1(9), ALDH9A1(2), CYP2C19(75), CYP2C9(38), DHRS1(3), DHRS2(8), DHRS3(4), DHRS7(1), DHRSX(6), ECHS1(3), EHHADH(6), ESCO1(2), ESCO2(4), HADHA(6), PNPLA3(3), SH3GLB1(2), YOD1(1) 12662765 214 112 198 127 136 20 13 18 27 0 0.769 1.000 1.000 233 HSA00970_AMINOACYL_TRNA_BIOSYNTHESIS Genes involved in aminoacyl-tRNA biosynthesis AARS, AARS2, CARS, CARS2, DARS, DARS2, EARS2, EPRS, FARS2, FARSA, FARSB, GARS, HARS, HARS2, IARS, IARS2, KARS, LARS, LARS2, MARS, MARS2, MTFMT, NARS, NARS2, PARS2, QARS, RARS, RARS2, SARS, SARS2, TARS, TARS2, VARS, VARS2, WARS, WARS2, YARS, YARS2 38 AARS(5), AARS2(3), CARS(8), CARS2(3), DARS(4), DARS2(3), EARS2(2), EPRS(13), FARS2(6), FARSA(8), FARSB(5), GARS(6), HARS(6), HARS2(4), IARS(8), IARS2(16), KARS(3), LARS(12), LARS2(5), MARS(7), MARS2(4), MTFMT(2), NARS(2), NARS2(6), QARS(6), RARS(7), RARS2(5), SARS(5), SARS2(4), TARS(5), TARS2(7), VARS(18), VARS2(7), WARS(5), WARS2(4), YARS(3), YARS2(2) 22332515 219 112 208 107 129 21 9 23 36 1 0.308 1.000 1.000 234 RHOPATHWAY RhoA is a G protein whose active form stabilizes actin structures such as focal adhesions and activates Rock1, which phosphorylates myosin light chains. ACTR2, ACTR3, ARHA, ARHGAP1, ARHGAP4, ARHGAP5, ARHGAP6, ARHGEF1, ARHGEF11, ARHGEF5, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, BAIAP2, CFL1, DIAPH1, GSN, LIMK1, MYL2, MYLK, OPHN1, PFN1, PIP5K1A, PIP5K1B, PPP1R12B, ROCK1, SRC, TLN1, VCL 30 ACTR2(3), ACTR3(2), ARHGAP1(3), ARHGAP4(4), ARHGAP5(13), ARHGAP6(11), ARHGEF1(1), ARHGEF11(20), ARHGEF5(18), ARPC1B(3), ARPC2(1), ARPC3(1), BAIAP2(7), CFL1(2), DIAPH1(9), GSN(6), LIMK1(5), MYL2(9), MYLK(46), OPHN1(4), PIP5K1A(6), PIP5K1B(21), PPP1R12B(7), ROCK1(7), SRC(2), TLN1(12), VCL(8) 18362367 231 112 221 110 162 13 9 24 23 0 0.0458 1.000 1.000 235 ST_GA12_PATHWAY G-alpha-12 promotes cell survival and proliferation, is involved in the stress response, and activates JNK. BF, BTK, DLG4, EPHB2, F2, F2RL1, F2RL2, F2RL3, JUN, MAP2K5, MAPK1, MAPK7, MAPK8, MYEF2, PLD1, PLD2, PLD3, PTK2, RAF1, RASAL1, SRC, TEC, VAV1 22 BTK(16), DLG4(6), EPHB2(34), F2(11), F2RL1(16), F2RL2(8), F2RL3(4), JUN(1), MAP2K5(4), MAPK1(4), MAPK7(4), MAPK8(1), MYEF2(4), PLD1(13), PLD2(8), PLD3(1), PTK2(7), RAF1(10), RASAL1(18), SRC(2), TEC(13), VAV1(19) 11172048 204 112 194 127 115 21 6 37 25 0 0.857 1.000 1.000 236 GPCRDB_CLASS_B_SECRETIN_LIKE ADCYAP1R1, CALCR, CALCRL, CD97, CRHR1, CRHR2, ELTD1, EMR1, EMR2, GCGR, GHRHR, GIPR, GLP1R, GLP2R, GPR64, LPHN1, LPHN2, LPHN3, PTHR1, PTHR2, SCTR, VIPR1, VIPR2 20 ADCYAP1R1(19), CALCR(18), CALCRL(19), CD97(7), CRHR1(7), CRHR2(4), ELTD1(27), EMR1(32), EMR2(5), GHRHR(5), GIPR(3), GLP1R(13), GLP2R(15), GPR64(4), LPHN1(7), LPHN2(46), LPHN3(22), SCTR(6), VIPR1(7), VIPR2(7) 10761386 273 111 253 174 195 19 7 15 37 0 0.231 1.000 1.000 237 VALINE_LEUCINE_AND_ISOLEUCINE_DEGRADATION ACAA1, ACAA2, ACADL, ACADM, ACADS, ACADSB, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH9A1, AOX1, BCAT1, BCKDHA, BCKDHB, ECHS1, EHHADH, HADHA, HADHB, HIBADH, HMGCL, IVD, MCCC1, MCCC2, MCEE, MUT, OXCT1, PCCA, PCCB, SDS 36 ACAA1(6), ACAA2(1), ACADL(5), ACADM(4), ACADS(5), ACADSB(5), ACAT2(1), ALDH1A1(5), ALDH1A2(14), ALDH1A3(2), ALDH1B1(11), ALDH2(7), ALDH3A1(8), ALDH3A2(3), ALDH6A1(4), ALDH9A1(2), AOX1(26), BCAT1(13), BCKDHA(2), BCKDHB(2), ECHS1(3), EHHADH(6), HADHA(6), HADHB(5), HIBADH(7), HMGCL(4), IVD(5), MCCC1(5), MCCC2(3), MCEE(2), MUT(6), OXCT1(4), PCCA(4), PCCB(3), SDS(2) 14747307 191 111 183 89 119 14 11 22 25 0 0.240 1.000 1.000 238 SPRYPATHWAY Four members of the Sprouty protein family block proliferative EGF signals by binding Grb-2, preventing Ras and MAP kinase activation. CBL, EGF, EGFR, GRB2, HRAS, MAP2K1, MAPK1, MAPK3, PTPRB, RAF1, RASA1, SHC1, SOS1, SPRY1, SPRY2, SPRY3, SPRY4, SRC 18 CBL(10), EGF(21), EGFR(25), GRB2(2), HRAS(3), MAP2K1(14), MAPK1(4), MAPK3(4), PTPRB(89), RAF1(10), RASA1(4), SHC1(2), SOS1(10), SPRY1(9), SPRY2(4), SPRY3(12), SPRY4(2), SRC(2) 10193609 227 110 205 95 151 18 5 28 25 0 0.119 1.000 1.000 239 ST_INTERLEUKIN_4_PATHWAY Like IL-13, IL-4 is produced by Th2 cells on activation of the T cell antigen receptor, and by mast and basophil cells on activation of the IgE receptor. AKT1, AKT2, AKT3, CISH, GRB2, IARS, IL13RA1, IL2RG, IL4, IL4R, INPP5D, JAK1, JAK2, JAK3, NR0B2, PI3, PIK3CA, PPP1R13B, RPS6KB1, SERPINA4, SHC1, SOS1, SOS2, SRC, STAT6, TYK2 26 AKT1(4), AKT2(8), AKT3(3), CISH(4), GRB2(2), IARS(8), IL13RA1(3), IL2RG(3), IL4(1), IL4R(16), INPP5D(37), JAK1(6), JAK2(8), JAK3(11), NR0B2(6), PI3(6), PIK3CA(10), PPP1R13B(9), RPS6KB1(3), SERPINA4(20), SHC1(2), SOS1(10), SOS2(13), SRC(2), STAT6(8), TYK2(8) 15023298 211 110 201 95 139 14 8 27 23 0 0.176 1.000 1.000 240 ALTERNATIVEPATHWAY The alternative complement pathway is an antibody-independent mechanism of immune activation that results in cell lysis via the membrane attack complex. BF, C3, C5, C6, C7, C8A, C9, DF, PFC 5 C3(48), C5(21), C6(72), C7(47), C9(22) 4592149 210 109 186 86 156 5 4 21 22 2 0.0221 1.000 1.000 241 ECMPATHWAY Extracellular matrix induces integrin-mediated FAK phosphorylation in epithelial cells, leading to PI3 and MAP kinase activation and actin reorganization. ARHA, ARHGAP5, DIAPH1, FYN, GSN, HRAS, ITGA1, ITGB1, MAP2K1, MAPK1, MAPK3, MYL2, MYLK, PFN1, PIK3CA, PIK3R1, PTK2, PXN, RAF1, ROCK1, SHC1, SRC, TLN1 22 ARHGAP5(13), DIAPH1(9), FYN(7), GSN(6), HRAS(3), ITGA1(24), ITGB1(4), MAP2K1(14), MAPK1(4), MAPK3(4), MYL2(9), MYLK(46), PIK3CA(10), PIK3R1(2), PTK2(7), PXN(2), RAF1(10), ROCK1(7), SHC1(2), SRC(2), TLN1(12) 15219421 197 109 179 87 122 13 7 32 22 1 0.149 1.000 1.000 242 ST_WNT_CA2_CYCLIC_GMP_PATHWAY Some Wnt glycoprotein/Frizzled receptor interactions increase intracellular calcium and decrease cGMP. BF, CAMK2A, CAMK2B, CAMK2D, CAMK2G, DAG1, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, NFAT5, PDE6A, PDE6B, PDE6C, PDE6D, PDE6G, PDE6H, SLC6A13, TF 19 CAMK2A(6), CAMK2B(6), CAMK2D(6), CAMK2G(5), DAG1(9), ITPKB(11), ITPR1(36), ITPR2(20), ITPR3(11), NFAT5(8), PDE6A(14), PDE6B(16), PDE6C(24), PDE6D(2), PDE6G(2), SLC6A13(30), TF(16) 14531071 222 109 208 125 154 11 7 18 32 0 0.0961 1.000 1.000 243 DCPATHWAY Dendritic cells internalize and present antigen, after which they migrate to lymphocyte-rich tissues and induce T and B cell differentiation. ANPEP, CD2, CD33, CD5, CD7, CSF2, IFNA1, IFNB1, IFNG, IL10, IL12A, IL12B, IL13, IL3, IL4, IL5, ITGAX, TLR2, TLR4, TLR7, TLR9, TNFRSF5 21 ANPEP(24), CD2(27), CD33(21), CD5(7), CD7(1), CSF2(2), IFNA1(1), IFNB1(6), IFNG(4), IL10(3), IL12A(4), IL12B(3), IL13(2), IL3(3), IL4(1), IL5(4), ITGAX(23), TLR2(15), TLR4(41), TLR7(17), TLR9(18) 7577421 227 108 211 114 162 19 10 13 23 0 0.000296 1.000 1.000 244 GSK3PATHWAY Bacterial lipopolysaccharide activates AKT to promote the survival and activation of macrophages and inhibits Gsk3-beta to promote beta-catenin accumulation in the nucleus. AKT1, APC, AXIN1, CCND1, CD14, CTNNB1, DVL1, FZD1, GJA1, GNAI1, GSK3B, IRAK1, LBP, LEF1, LY96, MYD88, NFKB1, PDPK1, PIK3CA, PIK3R1, PPP2CA, PRKR, RELA, TIRAP, TLR4, TOLLIP, WNT1 26 AKT1(4), APC(25), AXIN1(9), CCND1(2), CD14(5), CTNNB1(14), FZD1(5), GJA1(9), GNAI1(2), GSK3B(3), IRAK1(5), LBP(9), LEF1(3), LY96(4), MYD88(3), NFKB1(6), PDPK1(3), PIK3CA(10), PIK3R1(2), RELA(4), TIRAP(1), TLR4(41), TOLLIP(1), WNT1(2) 12425645 172 108 163 88 107 14 10 20 20 1 0.603 1.000 1.000 245 HSA00252_ALANINE_AND_ASPARTATE_METABOLISM Genes involved in alanine and aspartate metabolism AARS, AARS2, ABAT, ACY3, ADSL, ADSS, ADSSL1, AGXT, AGXT2, ASL, ASNS, ASPA, ASRGL1, ASS1, CAD, CRAT, DARS, DARS2, DDO, DLAT, DLD, GAD1, GAD2, GOT1, GOT2, GPT, GPT2, NARS, NARS2, PC, PDHA1, PDHA2, PDHB 32 AARS(5), AARS2(3), ABAT(9), ACY3(4), ADSL(5), ADSS(1), ADSSL1(7), AGXT(10), ASL(6), ASNS(8), ASPA(3), ASRGL1(6), ASS1(8), CAD(18), CRAT(5), DARS(4), DARS2(3), DDO(8), DLAT(4), DLD(3), GAD1(13), GAD2(9), GOT1(6), GOT2(6), GPT(3), GPT2(2), NARS(2), NARS2(6), PC(14), PDHA1(4), PDHA2(20), PDHB(1) 15064183 206 108 198 114 139 21 12 15 19 0 0.277 1.000 1.000 246 PROSTAGLANDIN_SYNTHESIS_REGULATION ANXA1, ANXA2, ANXA3, ANXA4, ANXA5, ANXA6, ANXA8, CYP11A1, EDN1, EDNRA, EDNRB, HPGD, HSD11B1, HSD11B2, PLA2G4A, PRL, PTGDR, PTGDS, PTGER1, PTGER2, PTGER4, PTGFR, PTGIR, PTGIS, PTGS1, PTGS2, S100A6, SCGB1A1, TBXAS1 26 ANXA1(7), ANXA2(8), ANXA3(4), ANXA4(2), ANXA5(1), ANXA6(5), CYP11A1(14), EDN1(9), EDNRA(10), EDNRB(7), HPGD(1), HSD11B2(3), PLA2G4A(15), PRL(3), PTGDR(11), PTGDS(3), PTGER2(7), PTGER4(2), PTGFR(21), PTGIR(5), PTGIS(17), PTGS1(20), PTGS2(13), S100A6(1), SCGB1A1(1), TBXAS1(16) 8108454 206 108 198 87 138 20 6 19 23 0 0.000682 1.000 1.000 247 CXCR4PATHWAY CXCR4 is a G-protein coupled receptor that responds to the ligand SDF-1 by activating Ras and PI3 kinase to promote lymphocyte chemotaxis. BCAR1, CRK, CXCL12, CXCR4, GNAI1, GNAQ, GNB1, GNGT1, HRAS, MAP2K1, MAPK1, MAPK3, NFKB1, PIK3C2G, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, PTK2, PTK2B, PXN, RAF1, RELA 23 BCAR1(5), CRK(3), CXCL12(3), CXCR4(3), GNAI1(2), GNAQ(6), GNB1(1), HRAS(3), MAP2K1(14), MAPK1(4), MAPK3(4), NFKB1(6), PIK3C2G(53), PIK3CA(10), PIK3R1(2), PLCG1(8), PRKCA(8), PTK2(7), PTK2B(10), PXN(2), RAF1(10), RELA(4) 11197709 168 107 147 88 108 12 6 26 15 1 0.539 1.000 1.000 248 BLYMPHOCYTEPATHWAY B cells express the major histocompatibility complex (class II MHC), immunoglobulins, adhesion proteins, and other factors on their cell surface. CD80, CR1, CR2, FCGR2B, HLA-DRA, HLA-DRB1, ICAM1, ITGAL, ITGB2, PTPRC, TNFRSF5 10 CD80(4), CR1(56), CR2(34), FCGR2B(4), HLA-DRA(12), ICAM1(2), ITGAL(28), ITGB2(16), PTPRC(35) 6150861 191 106 181 69 124 15 7 15 29 1 0.00617 1.000 1.000 249 HISTIDINE_METABOLISM ABP1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH9A1, AOC2, AOC3, ASPA, CNDP1, DDC, HAL, HARS, HARSL, HDC, HNMT, MAOA, MAOB, PRPS1, PRPS2 24 ABP1(22), ALDH1A1(5), ALDH1A2(14), ALDH1A3(2), ALDH1B1(11), ALDH2(7), ALDH3A1(8), ALDH3A2(3), ALDH3B1(3), ALDH3B2(8), ALDH9A1(2), AOC2(9), AOC3(10), ASPA(3), CNDP1(8), DDC(14), HAL(14), HARS(6), HDC(24), HNMT(2), MAOA(4), MAOB(13), PRPS1(2), PRPS2(2) 9929414 196 105 187 118 125 12 13 18 27 1 0.380 1.000 1.000 250 HSA00220_UREA_CYCLE_AND_METABOLISM_OF_AMINO_GROUPS Genes involved in urea cycle and metabolism of amino groups ABP1, ACY1, ADC, AGMAT, ALDH18A1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, AMD1, AOC2, AOC3, ARG1, ARG2, ASL, ASS1, CPS1, GATM, MAOA, MAOB, NAGS, ODC1, OTC, SAT1, SAT2, SMS, SRM 30 ABP1(22), ACY1(2), ADC(5), AGMAT(4), ALDH18A1(7), ALDH1A3(2), ALDH1B1(11), ALDH2(7), ALDH3A1(8), ALDH3A2(3), ALDH7A1(9), ALDH9A1(2), AOC2(9), AOC3(10), ARG1(2), ARG2(2), ASL(6), ASS1(8), CPS1(26), GATM(6), MAOA(4), MAOB(13), NAGS(1), ODC1(3), OTC(4), SMS(4), SRM(1) 11915809 181 105 175 102 104 16 12 21 28 0 0.385 1.000 1.000 251 HSA04614_RENIN_ANGIOTENSIN_SYSTEM Genes involved in renin-angiotensin system ACE, ACE2, AGT, AGTR1, AGTR2, ANPEP, CMA1, CPA3, CTSA, CTSG, ENPEP, LNPEP, MAS1, MME, NLN, REN, THOP1 17 ACE(37), ACE2(5), AGT(8), AGTR1(10), AGTR2(9), ANPEP(24), CMA1(5), CPA3(22), CTSA(5), CTSG(4), ENPEP(44), LNPEP(11), MAS1(4), MME(23), NLN(4), REN(11), THOP1(6) 8607814 232 105 216 112 162 19 11 11 29 0 0.00852 1.000 1.000 252 MONOCYTEPATHWAY Monocytes are a class of immune phagocytes that can develop into macrophages and express LFA-1, CD44, and other surface signaling proteins. CD44, ICAM1, ITGA4, ITGAL, ITGAM, ITGB1, ITGB2, PECAM1, SELE, SELL, SELP 11 CD44(5), ICAM1(2), ITGA4(43), ITGAL(28), ITGAM(23), ITGB1(4), ITGB2(16), SELE(33), SELL(10), SELP(39) 6444774 203 105 192 67 152 4 6 15 26 0 0.000168 1.000 1.000 253 ST_PHOSPHOINOSITIDE_3_KINASE_PATHWAY The phosphoinositide-3 kinase pathway produces the lipid second messenger PIP3 and regulates cell growth, survival, and movement. A1BG, AKT1, AKT2, AKT3, BAD, BTK, CDKN2A, CSL4, DAF, DAPP1, FOXO1A, GRB2, GSK3A, GSK3B, IARS, IGFBP1, INPP5D, P14, PDK1, PIK3CA, PPP1R13B, PSCD3, PTEN, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SFN, SHC1, SOS1, SOS2, TEC, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ 31 A1BG(2), AKT1(4), AKT2(8), AKT3(3), BTK(16), DAPP1(6), GRB2(2), GSK3A(1), GSK3B(3), IARS(8), IGFBP1(4), INPP5D(37), PDK1(2), PIK3CA(10), PPP1R13B(9), RPS6KA1(8), RPS6KA2(6), RPS6KA3(1), RPS6KB1(3), SHC1(2), SOS1(10), SOS2(13), TEC(13), YWHAB(1), YWHAE(2), YWHAG(2), YWHAQ(3) 14122683 179 105 167 69 112 13 11 22 21 0 0.0602 1.000 1.000 254 AT1RPATHWAY Binding of angiotensin II to AT1-R activates Ca2+ signaling and the JNK pathway. AGT, AGTR1, ATF2, CALM1, CALM2, CALM3, EGFR, ELK1, GNAQ, GRB2, HRAS, JUN, MAP2K1, MAP2K2, MAP2K4, MAP3K1, MAPK1, MAPK3, MAPK8, MEF2A, MEF2B, MEF2C, MEF2D, PAK1, PRKCA, PRKCB1, PTK2, PTK2B, RAC1, RAF1, SHC1, SOS1, SRC, SYT1 32 AGT(8), AGTR1(10), ATF2(6), CALM1(1), CALM2(1), EGFR(25), ELK1(3), GNAQ(6), GRB2(2), HRAS(3), JUN(1), MAP2K1(14), MAP2K2(5), MAP2K4(4), MAP3K1(4), MAPK1(4), MAPK3(4), MAPK8(1), MEF2A(3), MEF2B(2), MEF2C(4), MEF2D(6), PAK1(4), PRKCA(8), PTK2(7), PTK2B(10), RAF1(10), SHC1(2), SOS1(10), SRC(2), SYT1(23) 13470905 193 104 177 107 119 16 10 28 20 0 0.801 1.000 1.000 255 EDG1PATHWAY The lipid S1P is an EDG1 ligand promoting chemotaxis via Rac1 and cell survival and proliferation via ERK activation. ADCY1, AKT1, ARHA, ASAH1, EDG1, GNAI1, GNB1, GNGT1, ITGAV, ITGB3, MAPK1, MAPK3, PDGFA, PDGFRA, PIK3CA, PIK3R1, PLCB1, PRKCA, PRKCB1, PTK2, RAC1, SKIP, SMPD1, SMPD2, SPHK1, SRC 21 ADCY1(34), AKT1(4), GNAI1(2), GNB1(1), ITGAV(9), ITGB3(15), MAPK1(4), MAPK3(4), PDGFA(1), PDGFRA(34), PIK3CA(10), PIK3R1(2), PLCB1(54), PRKCA(8), PTK2(7), SMPD1(2), SMPD2(2), SPHK1(2), SRC(2) 11066832 197 104 188 95 137 12 6 22 19 1 0.142 1.000 1.000 256 MCALPAINPATHWAY In integrin-mediated cell migration, calpains digest links between the actin cytoskeleton and focal adhesion proteins. ACTA1, CAPN1, CAPN2, CAPNS1, CAPNS2, CXCR3, EGF, EGFR, HRAS, ITGA1, ITGB1, MAPK1, MAPK3, MYL2, MYLK, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTK2, PXN, TLN1, VIL2 24 ACTA1(4), CAPN1(4), CAPN2(5), CAPNS1(3), CAPNS2(1), CXCR3(4), EGF(21), EGFR(25), HRAS(3), ITGA1(24), ITGB1(4), MAPK1(4), MAPK3(4), MYL2(9), MYLK(46), PRKACB(4), PRKACG(11), PRKAR1A(3), PRKAR1B(4), PRKAR2A(1), PRKAR2B(5), PTK2(7), PXN(2), TLN1(12) 13256218 210 104 201 113 137 11 9 22 31 0 0.229 1.000 1.000 257 CARM_ERPATHWAY Methyltransferase CARM1 methylates CBP and co-activates estrogen receptors via Grip1. BRCA1, CARM1, CCND1, CREBBP, EP300, ERCC3, ESR1, GRIP1, GTF2A1, GTF2E1, GTF2F1, HDAC1, HDAC2, HDAC3, HDAC4, HDAC5, HDAC6, HIST2H3C, MEF2C, NCOR2, NR0B1, NRIP1, PELP1, POLR2A, PPARBP, PPARGC1, REA, SHARP, SRA1, TBP 25 BRCA1(15), CARM1(4), CCND1(2), CREBBP(24), EP300(18), ERCC3(6), ESR1(6), GRIP1(12), GTF2A1(2), GTF2E1(3), GTF2F1(5), HDAC1(2), HDAC2(2), HDAC3(5), HDAC4(11), HDAC5(6), HDAC6(2), MEF2C(4), NCOR2(26), NR0B1(3), NRIP1(8), PELP1(12), POLR2A(13), TBP(4) 18562312 195 103 194 84 128 9 12 30 16 0 0.145 1.000 1.000 258 PITX2PATHWAY The bicoid-related transcription factor Pitx2 is activated by Wnt binding to the Frizzled receptor and induces tissue-specific cell proliferation. APC, AXIN1, CREBBP, CTNNB1, DVL1, EP300, FZD1, GSK3B, HDAC1, HTATIP, LDB1, LEF1, PITX2, PPARBP, TRRAP, WNT1 14 APC(25), AXIN1(9), CREBBP(24), CTNNB1(14), EP300(18), FZD1(5), GSK3B(3), HDAC1(2), LDB1(3), LEF1(3), PITX2(5), TRRAP(46), WNT1(2) 13582453 159 103 153 84 83 16 12 24 24 0 0.822 1.000 1.000 259 HDACPATHWAY Myocyte enhancer factor MEF2 activates transcription of genes required for muscle cell differentiation and is inhibited by histone deacetylases. AKT1, AVP, CABIN1, CALM1, CALM2, CALM3, CAMK1, CAMK1G, HDAC5, IGF1, IGF1R, INS, INSR, MAP2K6, MAPK14, MAPK7, MEF2A, MEF2B, MEF2C, MEF2D, MYOD1, NFATC1, NFATC2, PIK3CA, PIK3R1, PPP3CA, PPP3CB, PPP3CC, SYT1, YWHAH 30 AKT1(4), CABIN1(16), CALM1(1), CALM2(1), CAMK1(5), CAMK1G(11), HDAC5(6), IGF1(10), IGF1R(14), INSR(26), MAP2K6(3), MAPK14(5), MAPK7(4), MEF2A(3), MEF2B(2), MEF2C(4), MEF2D(6), MYOD1(1), NFATC1(16), NFATC2(11), PIK3CA(10), PIK3R1(2), PPP3CA(5), PPP3CB(3), PPP3CC(2), SYT1(23) 14226207 194 102 182 97 126 16 11 23 17 1 0.184 1.000 1.000 260 P38MAPKPATHWAY The Rho family GTPases activate the p38 MAPKs under environmental stress or in the presence of pro-inflammatory cytokines. ATF2, CDC42, CREB1, DAXX, DDIT3, ELK1, GRB2, HMGN1, HRAS, HSPB1, HSPB2, MAP2K4, MAP2K6, MAP3K1, MAP3K5, MAP3K7, MAP3K9, MAPK14, MAPKAPK2, MAPKAPK5, MAX, MEF2A, MEF2B, MEF2C, MEF2D, MKNK1, MYC, PDZGEF1, PLA2G4A, RAC1, RIPK1, RPS6KA5, SHC1, STAT1, TGFB1, TGFB2, TGFB3, TGFBR1, TRADD, TRAF2 38 ATF2(6), CDC42(2), DAXX(9), DDIT3(2), ELK1(3), GRB2(2), HMGN1(2), HRAS(3), HSPB1(2), HSPB2(1), MAP2K4(4), MAP2K6(3), MAP3K1(4), MAP3K5(23), MAP3K7(1), MAP3K9(26), MAPK14(5), MAPKAPK2(5), MAPKAPK5(1), MEF2A(3), MEF2B(2), MEF2C(4), MEF2D(6), MKNK1(6), MYC(5), PLA2G4A(15), RIPK1(3), RPS6KA5(7), SHC1(2), STAT1(5), TGFB1(2), TGFB2(3), TGFB3(3), TRAF2(2) 14670780 172 102 167 66 108 13 6 24 21 0 0.0685 1.000 1.000 261 BADPATHWAY When phosphorylated, BAD is inhibited by sequestration; when non-phosphorylated, it promotes apoptosis by inactivating pro-survival BCL-XL and BCL-2. ADCY1, AKT1, BAD, BAX, BCL2, BCL2L1, CSF2RB, IGF1, IGF1R, IL3, IL3RA, KIT, KITLG, PIK3CA, PIK3R1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, YWHAH 22 ADCY1(34), AKT1(4), BAX(3), BCL2(2), CSF2RB(24), IGF1(10), IGF1R(14), IL3(3), IL3RA(7), KIT(12), KITLG(11), PIK3CA(10), PIK3R1(2), PRKACB(4), PRKACG(11), PRKAR1A(3), PRKAR1B(4), PRKAR2A(1), PRKAR2B(5) 8946667 164 101 157 84 101 18 9 14 21 1 0.175 1.000 1.000 262 HSA00534_HEPARAN_SULFATE_BIOSYNTHESIS Genes involved in heparan sulfate biosynthesis EXT1, EXT2, EXTL1, EXTL2, EXTL3, GLCE, HS2ST1, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, HS3ST5, HS6ST1, HS6ST2, HS6ST3, LOC728969, NDST1, NDST2, NDST3, NDST4 19 EXT1(2), EXT2(8), EXTL1(2), EXTL3(12), GLCE(8), HS2ST1(1), HS3ST1(10), HS3ST2(9), HS3ST3A1(6), HS3ST3B1(2), HS3ST5(8), HS6ST1(2), HS6ST2(3), HS6ST3(15), NDST1(6), NDST2(2), NDST3(25), NDST4(52) 8330521 173 101 167 94 112 12 6 20 23 0 0.237 1.000 1.000 263 HSA00640_PROPANOATE_METABOLISM Genes involved in propanoate metabolism ABAT, ACACA, ACACB, ACADM, ACAT1, ACAT2, ACSS1, ACSS2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH7A1, ALDH9A1, ECHS1, EHHADH, HADHA, HIBCH, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, LOC283398, MCEE, MLYCD, MUT, PCCA, PCCB, SUCLA2, SUCLG1, SUCLG2 33 ABAT(9), ACACA(20), ACACB(23), ACADM(4), ACAT2(1), ACSS1(2), ACSS2(4), ALDH1A3(2), ALDH1B1(11), ALDH2(7), ALDH3A1(8), ALDH3A2(3), ALDH6A1(4), ALDH7A1(9), ALDH9A1(2), ECHS1(3), EHHADH(6), HADHA(6), HIBCH(1), LDHA(4), LDHAL6A(4), LDHAL6B(6), LDHB(2), LDHC(5), MCEE(2), MLYCD(2), MUT(6), PCCA(4), PCCB(3), SUCLG1(3), SUCLG2(2) 16264740 168 101 162 96 97 13 17 21 20 0 0.721 1.000 1.000 264 HSA05110_CHOLERA_INFECTION Genes involved in cholera - infection ACTG1, ACTG2, ADCY3, ADCY9, AK1, ARF1, ARF3, ARF4, ARF5, ARF6, ARL4D, ATP6V0A1, ATP6V0A2, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0D1, ATP6V0D2, ATP6V0E1, ATP6V1A, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1E2, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, ERO1L, GNAS, PDIA4, PLCG1, PLCG2, PRKCA, SEC61A1, SEC61A2, SEC61B, SEC61G, TRIM23 41 ACTG1(6), ACTG2(6), ADCY3(3), ADCY9(10), AK1(1), ARF4(2), ARF5(2), ARF6(1), ARL4D(2), ATP6V0A1(12), ATP6V0A2(5), ATP6V0A4(22), ATP6V0D1(1), ATP6V0D2(10), ATP6V0E1(1), ATP6V1A(2), ATP6V1C1(1), ATP6V1C2(7), ATP6V1E1(1), ATP6V1E2(3), ATP6V1F(1), ATP6V1G2(1), ATP6V1G3(7), ATP6V1H(5), ERO1L(5), GNAS(25), PDIA4(5), PLCG1(8), PLCG2(27), PRKCA(8), SEC61A1(3), SEC61A2(4), TRIM23(2) 15138268 199 101 192 125 129 12 9 22 27 0 0.614 1.000 1.000 265 OXIDATIVE_PHOSPHORYLATION ATP12A, ATP4B, ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, ATP7A, ATP7B, COX10, COX4I1, COX5A, COX5B, COX6A1, COX6A2, COX6B1, COX6C, COX7A1, COX7A2, COX7B, COX7C, COX8A, NDUFA1, NDUFA10, NDUFA11, NDUFA4, NDUFA5, NDUFA8, NDUFB2, NDUFB4, NDUFB5, NDUFB6, NDUFB7, NDUFS1, NDUFS2, NDUFV1, NDUFV2, PP, PPA2, SDHA, SDHA, SDHAL2, SDHB, UQCRB, UQCRC1, UQCRFS1, UQCRH 60 ATP12A(27), ATP4B(1), ATP6AP1(3), ATP6V0A1(12), ATP6V0A4(22), ATP6V0D1(1), ATP6V1A(2), ATP6V1B1(4), ATP6V1B2(3), ATP6V1C1(1), ATP6V1C2(7), ATP6V1E1(1), ATP6V1F(1), ATP6V1G2(1), ATP6V1G3(7), ATP6V1H(5), ATP7A(12), ATP7B(21), COX10(6), COX5B(1), COX6A1(1), COX6B1(2), COX6C(1), COX7B(1), COX8A(1), NDUFA10(4), NDUFA4(1), NDUFB2(2), NDUFB5(3), NDUFB6(2), NDUFB7(2), NDUFS1(2), NDUFS2(3), NDUFV1(3), NDUFV2(1), PPA2(4), SDHA(3), SHMT1(2), UQCRC1(4), UQCRFS1(2) 15656087 182 101 180 110 110 13 15 23 20 1 0.766 1.000 1.000 266 PORPHYRIN_AND_CHLOROPHYLL_METABOLISM ALAD, BLVRA, BLVRB, CP, CPOX, EPRS, FECH, GUSB, HCCS, HMBS, HMOX1, HMOX2, PPOX, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4, UROD, UROS 26 ALAD(5), BLVRA(2), BLVRB(1), CP(12), CPOX(4), EPRS(13), FECH(3), GUSB(5), HCCS(2), HMBS(1), HMOX1(1), HMOX2(1), PPOX(4), UGT1A1(77), UGT2B15(31), UGT2B4(34), UROS(1) 11275147 197 101 183 83 137 16 7 13 23 1 0.0167 1.000 1.000 267 ST_P38_MAPK_PATHWAY p38 is a MAP kinase regulated by cytokines and cellular stress. AKT1, ATF1, CDC42, CREB1, CREB3, CREB5, DUSP1, DUSP10, EEF2K, EIF4E, ELK1, GADD45A, HSPB1, IL1R1, MAP2K3, MAP2K4, MAP2K6, MAP3K10, MAP3K4, MAP3K5, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAPK1, MAPK11, MAPK12, MAPK13, MAPK14, MAPKAPK2, MAPKAPK5, MKNK1, MKNK2, MYEF2, NFKB1, NR2C2, SRF, TRAF6 35 AKT1(4), ATF1(4), CDC42(2), CREB3(1), CREB5(9), DUSP1(1), DUSP10(7), EEF2K(6), ELK1(3), HSPB1(2), IL1R1(13), MAP2K3(8), MAP2K4(4), MAP2K6(3), MAP3K10(9), MAP3K4(17), MAP3K5(23), MAP3K7(1), MAPK1(4), MAPK11(1), MAPK12(1), MAPK13(5), MAPK14(5), MAPKAPK2(5), MAPKAPK5(1), MKNK1(6), MKNK2(3), MYEF2(4), NFKB1(6), NR2C2(1), SRF(3), TRAF6(4) 13581841 166 101 160 95 107 15 3 22 19 0 0.707 1.000 1.000 268 TRANSLATION_FACTORS ANKHD1, ANKHD1, MASK_BP3, EEF1A2, EEF1B2, EEF1D, EEF1G, EEF2, EEF2K, EIF1AX, EIF1AY, EIF2AK1, EIF2AK2, EIF2AK3, EIF2B1, EIF2B2, EIF2B3, EIF2B4, EIF2B5, EIF2S1, EIF2S2, EIF2S3, EIF3S1, EIF3S10, EIF3S2, EIF3S3, EIF3S4, EIF3S5, EIF3S6, EIF3S7, EIF3S8, EIF3S9, EIF4A1, EIF4A2, EIF4E, EIF4EBP1, EIF4EBP2, EIF4G1, EIF4G3, EIF5, EIF5A, EIF5B, ETF1, GSPT2, ITGB4BP, KIAA0664, PABPC1, PABPC3, PABPC1, LOC341315, PAIP1, PAIP1, LOC388345, SLC35A4, SUI1, WBSCR1 37 EEF1A2(10), EEF1B2(1), EEF1D(6), EEF1G(5), EEF2(4), EEF2K(6), EIF1AX(3), EIF2AK1(4), EIF2AK2(6), EIF2AK3(16), EIF2B1(1), EIF2B2(1), EIF2B3(3), EIF2B4(1), EIF2B5(2), EIF2S1(1), EIF2S3(1), EIF4A1(4), EIF4A2(4), EIF4EBP1(1), EIF4G1(18), EIF4G3(17), EIF5(2), EIF5B(3), ETF1(2), GSPT2(9), KIAA0664(5), PABPC1(5), PABPC3(8), PAIP1(8), SLC35A4(4) 17819622 161 101 160 81 90 15 12 21 23 0 0.678 1.000 1.000 269 HSA00361_GAMMA_HEXACHLOROCYCLOHEXANE_DEGRADATION Genes involved in gamma-hexachlorocyclohexane degradation ACP1, ACP2, ACP5, ACP6, ACPP, ACPT, ALPI, ALPL, ALPP, ALPPL2, CMBL, CYP3A4, CYP3A43, CYP3A5, CYP3A7, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, PON1, PON2, PON3 23 ACP1(4), ACP2(2), ACP5(3), ACP6(12), ACPP(9), ACPT(3), ALPI(9), ALPL(11), ALPP(10), ALPPL2(12), CMBL(5), CYP3A4(20), CYP3A43(19), CYP3A7(30), DHRS1(3), DHRS2(8), DHRS3(4), DHRS7(1), DHRSX(6), PON1(21), PON2(2) 7336796 194 100 183 71 141 10 6 12 25 0 3.37e-05 1.000 1.000 270 IL2RBPATHWAY The beta subunit of the IL-2 receptor is required for IL-2 and IL-15 signal recognition and activates JAK kinase on ligand binding. AKT1, BAD, BCL2, BCL2L1, CBL, CFLAR, CRKL, E2F1, FOS, GRB2, HRAS, IL2RA, IL2RB, IL2RG, IRS1, JAK1, JAK3, MAPK1, MAPK3, MYC, NMI, PIK3CA, PIK3R1, PPIA, PTPN6, RAF1, RPS6KB1, SHC1, SOCS1, SOCS3, SOS1, STAT5A, STAT5B, SYK, TNFRSF6, TNFSF6, ZNFN1A3 34 AKT1(4), BCL2(2), CBL(10), CFLAR(4), CRKL(3), E2F1(5), FOS(2), GRB2(2), HRAS(3), IL2RA(5), IL2RB(12), IL2RG(3), IRS1(5), JAK1(6), JAK3(11), MAPK1(4), MAPK3(4), MYC(5), NMI(4), PIK3CA(10), PIK3R1(2), PPIA(1), PTPN6(5), RAF1(10), RPS6KB1(3), SHC1(2), SOCS1(1), SOCS3(1), SOS1(10), STAT5A(3), STAT5B(6), SYK(14) 14699858 162 100 160 85 89 16 10 27 19 1 0.632 1.000 1.000 271 AMIPATHWAY Endogenous anti-thrombosis pathways are overwhelmed in plaque-narrowed blood vessels, resulting in potentially lethal myocardial infarction. ADCY1, CD3D, CD3E, CD3G, CD3Z, CD4, CREBBP, CSK, GNAS, GNB1, GNGT1, HLA-DRA, HLA-DRB1, LCK, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTPRC, TRA@, TRB@, ZAP70 21 ADCY1(34), CD3D(7), CD3E(2), CD3G(1), CD4(8), CREBBP(24), CSK(1), GNAS(25), GNB1(1), HLA-DRA(12), LCK(15), PRKACB(4), PRKACG(11), PRKAR1A(3), PRKAR1B(4), PRKAR2A(1), PRKAR2B(5), PTPRC(35), ZAP70(7) 9274339 200 99 191 99 124 22 11 19 24 0 0.199 1.000 1.000 272 APOPTOSIS_KEGG APAF1, BAD, BAX, BCL2, BCL2A1, BCL2L1, BCL2L2, BOK, CASP1, CASP1, COPl, CASP10, CASP2, CASP3, CASP4, CASP6, CASP7, CASP8, CASP9, CD40, CD40LG, CRADD, CYCS, DAXX, DFFA, DFFB, FADD, FAS, FASLG, HRK, IKBKE, LTA, MCL1, NFKB1, NFKBIA, NGFB, NGFR, NR3C1, NTRK1, PTPN13, RIPK1, SFRS2IP, TFG, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF1, TRAF2, TRAF3, TRAF6 47 APAF1(6), BAX(3), BCL2(2), BCL2A1(2), CASP1(10), CASP10(6), CASP2(1), CASP3(2), CASP4(2), CASP7(4), CASP8(9), CASP9(2), CD40(4), CD40LG(2), CRADD(2), CYCS(1), DAXX(9), DFFA(2), DFFB(2), FAS(6), FASLG(15), IKBKE(10), LTA(4), MCL1(3), NFKB1(6), NFKBIA(2), NGFR(8), NR3C1(7), NTRK1(16), PTPN13(15), RIPK1(3), TFG(2), TNF(1), TNFRSF1A(4), TNFRSF1B(4), TRAF1(6), TRAF2(2), TRAF3(5), TRAF6(4) 17668850 194 99 191 108 124 14 8 23 25 0 0.742 1.000 1.000 273 CSKPATHWAY Csk inhibits T-cell activation by phosphorylating Lck; Csk is regulated by cAMP-dependent kinases and is opposed by the T-cell activator CD45. ADCY1, CD3D, CD3E, CD3G, CD3Z, CD4, CREBBP, CSK, GNAS, GNB1, GNGT1, HLA-DRA, HLA-DRB1, LCK, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTPRC, TRA@, TRB@, ZAP70 21 ADCY1(34), CD3D(7), CD3E(2), CD3G(1), CD4(8), CREBBP(24), CSK(1), GNAS(25), GNB1(1), HLA-DRA(12), LCK(15), PRKACB(4), PRKACG(11), PRKAR1A(3), PRKAR1B(4), PRKAR2A(1), PRKAR2B(5), PTPRC(35), ZAP70(7) 9274339 200 99 191 99 124 22 11 19 24 0 0.199 1.000 1.000 274 IL1RPATHWAY The cytokine IL-1 stimulates its primary receptor, IL-1R1, which induces transcription of inflammation-related genes such as interferons. CHUK, IFNA1, IFNB1, IKBKB, IL1A, IL1B, IL1R1, IL1RAP, IL1RN, IL6, IRAK1, IRAK2, IRAK3, JUN, MAP2K3, MAP2K6, MAP3K1, MAP3K14, MAP3K7, MAP3K7IP1, MAPK14, MAPK8, MYD88, NFKB1, NFKBIA, RELA, SITPEC, TGFB1, TGFB2, TGFB3, TNF, TOLLIP, TRAF6 31 CHUK(2), IFNA1(1), IFNB1(6), IKBKB(4), IL1A(5), IL1B(8), IL1R1(13), IL1RAP(3), IL1RN(9), IL6(2), IRAK1(5), IRAK2(15), IRAK3(10), JUN(1), MAP2K3(8), MAP2K6(3), MAP3K1(4), MAP3K14(6), MAP3K7(1), MAPK14(5), MAPK8(1), MYD88(3), NFKB1(6), NFKBIA(2), RELA(4), TGFB1(2), TGFB2(3), TGFB3(3), TNF(1), TOLLIP(1), TRAF6(4) 12037140 141 99 138 74 89 14 5 14 19 0 0.380 1.000 1.000 275 FIBRINOLYSISPATHWAY Thrombin cleavage of fibrinogen results in rapid formation of fibrin threads that form a mesh to capture platelets and other blood cells into a clot. CPB2, F13A1, F2, F2R, FGA, FGB, FGG, PLAT, PLAU, PLG, SERPINB2, SERPINE1 12 CPB2(1), F13A1(27), F2(11), F2R(8), FGA(41), FGB(10), FGG(10), PLAT(4), PLAU(3), PLG(34), SERPINB2(36), SERPINE1(5) 5452253 190 98 180 71 131 13 10 20 16 0 0.0210 1.000 1.000 276 HSA00770_PANTOTHENATE_AND_COA_BIOSYNTHESIS Genes involved in pantothenate and CoA biosynthesis BCAT1, BCAT2, COASY, DPYD, DPYS, ENPP1, ENPP3, ILVBL, PANK1, PANK2, PANK3, PANK4, PPCDC, PPCS, UPB1, VNN1 16 BCAT1(13), BCAT2(1), COASY(6), DPYD(67), DPYS(24), ENPP1(13), ENPP3(13), ILVBL(5), PANK1(3), PANK2(3), PANK3(2), PANK4(6), PPCS(3), UPB1(10), VNN1(7) 7049698 176 98 158 51 130 11 3 18 14 0 1.79e-05 1.000 1.000 277 ST_GAQ_PATHWAY G-alpha-q activates phospholipase C, resulting in calcium influx and increasing protein kinase C activity. ADRBK1, AKT1, AKT2, AKT3, BF, DAG1, GNAQ, IKBKG, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PDK1, PHKA2, PIK3CB, PITX2, PLD1, PLD2, PLD3, VN1R1 26 ADRBK1(6), AKT1(4), AKT2(8), AKT3(3), DAG1(9), GNAQ(6), ITPKB(11), ITPR1(36), ITPR2(20), ITPR3(11), NFKB1(6), NFKB2(3), NFKBIA(2), NFKBIB(1), NFKBIL1(3), PDK1(2), PHKA2(9), PIK3CB(14), PITX2(5), PLD1(13), PLD2(8), PLD3(1), VN1R1(1) 18263848 182 98 173 108 98 18 14 29 23 0 0.546 1.000 1.000 278 ST_GRANULE_CELL_SURVIVAL_PATHWAY The survival and differentiation of granule cells in the brain is controlled by pro-growth PACAP and pro-apoptotic ceramides. ADPRT, APC, ASAH1, CAMP, CASP3, CERK, CREB1, CREB3, CREB5, CXCL2, DAG1, EPHB2, FOS, GNAQ, IL8RB, ITPKA, ITPKB, JUN, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, PACAP 25 APC(25), CAMP(2), CASP3(2), CERK(1), CREB3(1), CREB5(9), DAG1(9), EPHB2(34), FOS(2), GNAQ(6), ITPKB(11), JUN(1), MAP2K4(4), MAP2K7(5), MAPK1(4), MAPK10(9), MAPK8(1), MAPK8IP1(7), MAPK8IP2(7), MAPK8IP3(10), MAPK9(3) 11616008 153 98 148 90 97 11 7 17 21 0 0.825 1.000 1.000 279 BUTANOATE_METABOLISM AACS, ABAT, ACADS, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH5A1, ALDH9A1, BDH, BUCS1, ECHS1, EHHADH, GAD1, GAD2, HADHA, HMGCL, L2HGDH, OXCT1, PDHA1, PDHA2, PDHB, SDHB, SDS 27 AACS(8), ABAT(9), ACADS(5), ACAT2(1), ALDH1A1(5), ALDH1A2(14), ALDH1A3(2), ALDH1B1(11), ALDH2(7), ALDH3A1(8), ALDH3A2(3), ALDH5A1(10), ALDH9A1(2), ECHS1(3), EHHADH(6), GAD1(13), GAD2(9), HADHA(6), HMGCL(4), L2HGDH(3), OXCT1(4), PDHA1(4), PDHA2(20), PDHB(1), SDS(2) 10579213 160 97 153 72 96 17 7 18 22 0 0.0651 1.000 1.000 280 HSA05050_DENTATORUBROPALLIDOLUYSIAN_ATROPHY Genes involved in dentatorubropallidoluysian atrophy (DRPLA) ATN1, BAIAP2, CASP1, CASP3, CASP7, CASP8, GAPDH, INS, INSR, ITCH, MAGI1, MAGI2, RERE, WWP1, WWP2 15 ATN1(7), BAIAP2(7), CASP1(10), CASP3(2), CASP7(4), CASP8(9), GAPDH(2), INSR(26), ITCH(8), MAGI1(31), MAGI2(24), RERE(23), WWP1(5), WWP2(9) 9840516 167 97 161 70 110 11 5 20 20 1 0.173 1.000 1.000 281 EXTRINSICPATHWAY The extrinsic prothrombin activation pathway requires the release of thromboplastin from damaged tissues to activate the blood clotting cascade. F10, F2, F2R, F3, F5, F7, FGA, FGB, FGG, PROC, PROS1, SERPINC1, TFPI 13 F10(7), F2(11), F2R(8), F3(2), F5(36), F7(7), FGA(41), FGB(10), FGG(10), PROC(12), PROS1(18), SERPINC1(8), TFPI(7) 6703275 177 96 163 69 118 20 9 19 11 0 0.0507 1.000 1.000 282 HSA00251_GLUTAMATE_METABOLISM Genes involved in glutamate metabolism ABAT, ADC, ALDH4A1, ALDH5A1, CAD, CPS1, EARS2, EPRS, GAD1, GAD2, GCLC, GCLM, GFPT1, GFPT2, GLS, GLS2, GLUD1, GLUD2, GLUL, GMPS, GNPNAT1, GOT1, GOT2, GPT, GPT2, GSR, GSS, NADSYN1, NAGK, PPAT, QARS 31 ABAT(9), ADC(5), ALDH4A1(6), ALDH5A1(10), CAD(18), CPS1(26), EARS2(2), EPRS(13), GAD1(13), GAD2(9), GCLC(5), GCLM(2), GFPT1(4), GFPT2(8), GLS(2), GLS2(3), GLUD1(2), GLUD2(4), GLUL(2), GMPS(6), GOT1(6), GOT2(6), GPT(3), GPT2(2), GSR(2), GSS(8), NADSYN1(4), NAGK(1), QARS(6) 16134509 187 96 180 101 109 23 10 26 19 0 0.414 1.000 1.000 283 HSA03022_BASAL_TRANSCRIPTION_FACTORS Genes involved in basal transcription factors GTF2A1, GTF2A1L, GTF2A2, GTF2B, GTF2E1, GTF2E2, GTF2F1, GTF2F2, GTF2H1, GTF2H2, GTF2H3, GTF2H4, GTF2I, GTF2IRD1, LOC391764, STON1, TAF1, TAF10, TAF12, TAF13, TAF1L, TAF2, TAF4, TAF4B, TAF5, TAF5L, TAF6, TAF6L, TAF7, TAF7L, TAF9, TAF9B, TBPL1, TBPL2 32 GTF2A1(2), GTF2A2(1), GTF2B(4), GTF2E1(3), GTF2E2(5), GTF2F1(5), GTF2F2(2), GTF2H1(3), GTF2H3(1), GTF2H4(2), GTF2I(2), GTF2IRD1(10), TAF1(14), TAF13(2), TAF1L(56), TAF2(8), TAF4(10), TAF4B(5), TAF5L(4), TAF6(4), TAF6L(3), TAF7(2), TAF7L(13), TAF9B(1), TBPL1(1), TBPL2(7) 14784311 170 96 166 71 114 12 6 22 16 0 0.215 1.000 1.000 284 PAR1PATHWAY Activated extracellular thrombin cleaves and activates the G-protein coupled receptors PAR1 and PAR4, which activate platelets. ADCY1, ARHA, ARHGEF1, F2, F2R, F2RL3, GNA12, GNA13, GNAI1, GNAQ, GNB1, GNGT1, MAP3K7, PIK3CA, PIK3R1, PLCB1, PPP1R12B, PRKCA, PRKCB1, PTK2B, ROCK1 19 ADCY1(34), ARHGEF1(1), F2(11), F2R(8), F2RL3(4), GNA12(3), GNA13(1), GNAI1(2), GNAQ(6), GNB1(1), MAP3K7(1), PIK3CA(10), PIK3R1(2), PLCB1(54), PPP1R12B(7), PRKCA(8), PTK2B(10), ROCK1(7) 10546293 170 96 160 86 112 13 8 21 15 1 0.316 1.000 1.000 285 PDGFPATHWAY Platelet-derived growth factor (PDGF) receptor is phosphorylated on ligand binding and promotes cell proliferation. CSNK2A1, ELK1, FOS, GRB2, HRAS, JAK1, JUN, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, PDGFA, PDGFRA, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, RAF1, RASA1, SHC1, SOS1, SRF, STAT1, STAT3, STAT5A 26 CSNK2A1(4), ELK1(3), FOS(2), GRB2(2), HRAS(3), JAK1(6), JUN(1), MAP2K1(14), MAP2K4(4), MAP3K1(4), MAPK3(4), MAPK8(1), PDGFA(1), PDGFRA(34), PIK3CA(10), PIK3R1(2), PLCG1(8), PRKCA(8), RAF1(10), RASA1(4), SHC1(2), SOS1(10), SRF(3), STAT1(5), STAT3(9), STAT5A(3) 14238664 157 95 148 71 84 17 7 33 15 1 0.440 1.000 1.000 286 PROPANOATE_METABOLISM ABAT, ACACA, ACADL, ACADM, ACADSB, ACAS2, ACAS2L, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH9A1, ECHS1, EHHADH, HADHA, LDHA, LDHB, LDHC, MCEE, MLYCD, MUT, PCCA, PCCB, SDS, SUCLA2, SUCLG1, SUCLG2 31 ABAT(9), ACACA(20), ACADL(5), ACADM(4), ACADSB(5), ACAT2(1), ALDH1A1(5), ALDH1A2(14), ALDH1A3(2), ALDH1B1(11), ALDH2(7), ALDH3A1(8), ALDH3A2(3), ALDH6A1(4), ALDH9A1(2), ECHS1(3), EHHADH(6), HADHA(6), LDHA(4), LDHB(2), LDHC(5), MCEE(2), MLYCD(2), MUT(6), PCCA(4), PCCB(3), SDS(2), SUCLG1(3), SUCLG2(2) 13572166 150 95 145 75 92 11 12 18 17 0 0.454 1.000 1.000 287 PYK2PATHWAY Pyk2 and Rac1 stimulate the JNK cascade and activate MKK3, which activates p38. BCAR1, CALM1, CALM2, CALM3, CRKL, GNAQ, GRB2, HRAS, JUN, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP3K1, MAPK1, MAPK14, MAPK3, MAPK8, PAK1, PLCG1, PRKCA, PRKCB1, PTK2B, RAC1, RAF1, SHC1, SOS1, SRC, SYT1 27 BCAR1(5), CALM1(1), CALM2(1), CRKL(3), GNAQ(6), GRB2(2), HRAS(3), JUN(1), MAP2K1(14), MAP2K2(5), MAP2K3(8), MAP2K4(4), MAP3K1(4), MAPK1(4), MAPK14(5), MAPK3(4), MAPK8(1), PAK1(4), PLCG1(8), PRKCA(8), PTK2B(10), RAF1(10), SHC1(2), SOS1(10), SRC(2), SYT1(23) 11441235 148 95 134 80 83 15 8 26 16 0 0.736 1.000 1.000 288 EGFPATHWAY The epidermal growth factor (EGF) peptide stimulates the EGF receptor to promote cell proliferation via the MAP kinase and Ras pathways. CSNK2A1, EGF, EGFR, ELK1, FOS, GRB2, HRAS, JAK1, JUN, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, RAF1, RASA1, SHC1, SOS1, SRF, STAT1, STAT3, STAT5A 26 CSNK2A1(4), EGF(21), EGFR(25), ELK1(3), FOS(2), GRB2(2), HRAS(3), JAK1(6), JUN(1), MAP2K1(14), MAP2K4(4), MAP3K1(4), MAPK3(4), MAPK8(1), PIK3CA(10), PIK3R1(2), PLCG1(8), PRKCA(8), RAF1(10), RASA1(4), SHC1(2), SOS1(10), SRF(3), STAT1(5), STAT3(9), STAT5A(3) 15292073 168 94 159 84 89 18 8 33 19 1 0.727 1.000 1.000 289 G2PATHWAY Activated Cdc2-cyclin B kinase regulates the G2/M transition; DNA damage stimulates the DNA-PK/ATM/ATR kinases, which inactivate Cdc2. ATM, ATR, BRCA1, CCNB1, CDC2, CDC25A, CDC25B, CDC25C, CDC34, CDKN1A, CDKN2D, CHEK1, CHEK2, EP300, GADD45A, MDM2, MYT1, PLK, PRKDC, RPS6KA1, TP53, WEE1, YWHAH, YWHAQ 21 ATM(15), ATR(23), BRCA1(15), CDC25A(8), CDC25B(4), CDC25C(5), CDC34(3), CDKN1A(3), CHEK1(2), CHEK2(2), EP300(18), MDM2(1), MYT1(21), PRKDC(19), RPS6KA1(8), WEE1(2), YWHAQ(3) 16785541 152 94 149 70 98 12 7 20 15 0 0.563 1.000 1.000 290 HSA00710_CARBON_FIXATION Genes involved in carbon fixation ALDOA, ALDOB, ALDOC, FBP1, FBP2, GOT1, GOT2, GPT, GPT2, MDH1, MDH2, ME1, ME3, PGK1, PGK2, PKLR, PKM2, RPE, RPIA, TKT, TKTL1, TKTL2, TPI1 23 ALDOA(2), ALDOB(14), ALDOC(4), FBP1(3), FBP2(2), GOT1(6), GOT2(6), GPT(3), GPT2(2), MDH1(3), MDH2(3), ME1(20), ME3(8), PGK1(2), PGK2(35), PKLR(13), PKM2(7), TKT(6), TKTL1(3), TKTL2(26), TPI1(1) 8273052 169 94 157 91 128 15 4 10 11 1 0.0288 1.000 1.000 291 HSA04120_UBIQUITIN_MEDIATED_PROTEOLYSIS Genes involved in ubiquitin mediated proteolysis ANAPC1, ANAPC10, ANAPC11, ANAPC2, ANAPC4, ANAPC5, ANAPC7, BTRC, CDC16, CDC20, CDC23, CDC26, CDC27, CUL1, CUL2, CUL3, FBXW11, FBXW7, FZR1, ITCH, LOC728919, RBX1, SKP1, SKP2, SMURF1, SMURF2, TCEB1, TCEB2, UBA1, UBE2C, UBE2D1, UBE2D2, UBE2D3, UBE2D4, UBE2E1, UBE2E2, UBE2E3, VHL, WWP1, WWP2 39 ANAPC1(17), ANAPC10(1), ANAPC2(6), ANAPC4(6), ANAPC5(10), ANAPC7(6), BTRC(4), CDC16(1), CDC20(1), CDC23(4), CDC27(13), CUL1(5), CUL2(4), CUL3(5), FBXW11(6), FBXW7(11), FZR1(7), ITCH(8), SKP2(2), SMURF1(2), SMURF2(9), TCEB1(1), TCEB2(1), UBA1(2), UBE2D1(1), UBE2D3(2), UBE2E1(1), UBE2E2(4), UBE2E3(1), VHL(4), WWP1(5), WWP2(9) 16265280 159 94 153 60 95 6 8 24 25 1 0.208 1.000 1.000 292 HSA00641_3_CHLOROACRYLIC_ACID_DEGRADATION Genes involved in 3-chloroacrylic acid degradation ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1 15 ADH1A(17), ADH1B(30), ADH1C(1), ADH4(10), ADH5(3), ADH6(14), ADH7(16), ADHFE1(6), ALDH1A3(2), ALDH1B1(11), ALDH2(7), ALDH3A1(8), ALDH3A2(3), ALDH7A1(9), ALDH9A1(2) 5400238 139 93 120 47 98 9 10 12 10 0 0.000345 1.000 1.000 293 PANTOTHENATE_AND_COA_BIOSYNTHESIS BCAT1, COASY, DPYD, DPYS, ENPP1, ENPP3, PANK1, PANK2, PANK3, PANK4, PPCS, UPB1 12 BCAT1(13), COASY(6), DPYD(67), DPYS(24), ENPP1(13), ENPP3(13), PANK1(3), PANK2(3), PANK3(2), PANK4(6), PPCS(3), UPB1(10) 5679537 163 93 145 46 118 11 3 18 13 0 0.000108 1.000 1.000 294 BIOGENIC_AMINE_SYNTHESIS AANAT, ACHE, CHAT, COMT, DBH, DDC, DXYS155E, GAD1, GAD2, HDC, MAOA, PAH, PNMT, SLC18A3, TH, TPH1 15 AANAT(1), ACHE(8), CHAT(17), COMT(3), DBH(15), DDC(14), GAD1(13), GAD2(9), HDC(24), MAOA(4), PAH(12), PNMT(4), SLC18A3(2), TH(12), TPH1(12) 5772200 150 92 141 87 108 12 5 5 20 0 0.112 1.000 1.000 295 CREBPATHWAY CREB is a transcription factor that binds to cAMP-responsive elements (CREs) to activate transcription in response to extracellular signaling. ADCY1, AKT1, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CREB1, GNAS, GRB2, HRAS, MAPK1, MAPK14, MAPK3, PIK3CA, PIK3R1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, RAC1, RPS6KA1, RPS6KA5, SOS1 25 ADCY1(34), AKT1(4), CAMK2A(6), CAMK2B(6), CAMK2D(6), CAMK2G(5), GNAS(25), GRB2(2), HRAS(3), MAPK1(4), MAPK14(5), MAPK3(4), PIK3CA(10), PIK3R1(2), PRKACB(4), PRKACG(11), PRKAR1A(3), PRKAR1B(4), PRKAR2A(1), PRKAR2B(5), PRKCA(8), RPS6KA1(8), RPS6KA5(7), SOS1(10) 11654496 177 92 171 104 108 19 9 21 19 1 0.857 1.000 1.000 296 EIF4PATHWAY The eIF-4F complex recognizes 5' mRNA caps, recruits RNA helicases, and maintains mRNA-ribosome bridging. AKT1, EIF4A1, EIF4A2, EIF4E, EIF4EBP1, EIF4G1, EIF4G2, EIF4G3, FRAP1, GHR, IRS1, MAPK1, MAPK14, MAPK3, MKNK1, PABPC1, PDK2, PDPK1, PIK3CA, PIK3R1, PRKCA, PRKCB1, PTEN, RPS6KB1 21 AKT1(4), EIF4A1(4), EIF4A2(4), EIF4EBP1(1), EIF4G1(18), EIF4G2(4), EIF4G3(17), GHR(40), IRS1(5), MAPK1(4), MAPK14(5), MAPK3(4), MKNK1(6), PABPC1(5), PDK2(4), PDPK1(3), PIK3CA(10), PIK3R1(2), PRKCA(8), RPS6KB1(3) 11232196 151 92 143 56 93 16 8 14 19 1 0.0529 1.000 1.000 297 HSA00051_FRUCTOSE_AND_MANNOSE_METABOLISM Genes involved in fructose and mannose metabolism AKR1B1, AKR1B10, ALDOA, ALDOB, ALDOC, FBP1, FBP2, FPGT, FUK, GMDS, GMPPA, GMPPB, HK1, HK2, HK3, HSD3B7, KHK, LHPP, MPI, MTMR1, MTMR2, MTMR6, PFKFB1, PFKFB2, PFKFB3, PFKFB4, PFKL, PFKM, PFKP, PGM2, PHPT1, PMM1, PMM2, RDH11, RDH12, RDH13, RDH14, SORD, TPI1, TSTA3, UGCGL1, UGCGL2 40 AKR1B1(2), AKR1B10(9), ALDOA(2), ALDOB(14), ALDOC(4), FBP1(3), FBP2(2), FUK(5), GMDS(5), GMPPA(1), GMPPB(4), HK1(3), HK2(13), HK3(14), HSD3B7(5), KHK(1), LHPP(1), MPI(1), MTMR1(5), MTMR2(2), MTMR6(2), PFKFB1(4), PFKFB2(5), PFKFB3(2), PFKFB4(6), PFKL(4), PFKM(2), PFKP(2), PGM2(7), PMM1(3), PMM2(2), RDH11(1), RDH12(2), RDH13(3), SORD(2), TPI1(1), TSTA3(4) 15068605 148 92 144 102 98 16 10 8 16 0 0.639 1.000 1.000 298 IL7PATHWAY IL-7 is required for B and T cell development and proliferation and may contribute to activation of VDJ recombination. BCL2, CREBBP, EP300, FYN, IL2RG, IL7, IL7R, JAK1, JAK3, LCK, NMI, PIK3CA, PIK3R1, PTK2B, STAT5A, STAT5B 16 BCL2(2), CREBBP(24), EP300(18), FYN(7), IL2RG(3), IL7(4), IL7R(34), JAK1(6), JAK3(11), LCK(15), NMI(4), PIK3CA(10), PIK3R1(2), PTK2B(10), STAT5A(3), STAT5B(6) 11392453 159 92 156 77 93 18 8 23 15 2 0.410 1.000 1.000 299 PENTOSE_AND_GLUCURONATE_INTERCONVERSIONS AKR1B1, DCXR, GUSB, RPE, RPE, LOC440001, UCHL1, UCHL3, UGDH, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4 18 AKR1B1(2), GUSB(5), UCHL1(5), UCHL3(2), UGDH(1), UGT1A1(77), UGT2B15(31), UGT2B4(34) 7231093 157 92 140 71 114 13 6 6 17 1 0.0206 1.000 1.000 300 APOPTOSIS_GENMAPP APAF1, BAK1, BCL2L7P1, BAX, BCL2, BCL2L1, BID, BIRC2, BIRC3, BIRC4, CASP2, CASP3, CASP6, CASP7, CASP8, CASP9, CYCS, FADD, FAS, FASLG, GZMB, IKBKG, JUN, MAP2K4, MAP3K1, MAP3K14, MAPK10, MCL1, MDM2, MYC, NFKB1, NFKBIA, PARP1, PRF1, RELA, RIPK1, TNF, TNFRSF1A, TNFRSF1B, TNFSF10, TP53, TRADD, TRAF1, TRAF2 40 APAF1(6), BAK1(1), BAX(3), BCL2(2), BIRC2(6), BIRC3(7), CASP2(1), CASP3(2), CASP7(4), CASP8(9), CASP9(2), CYCS(1), FAS(6), FASLG(15), GZMB(3), JUN(1), MAP2K4(4), MAP3K1(4), MAP3K14(6), MAPK10(9), MCL1(3), MDM2(1), MYC(5), NFKB1(6), NFKBIA(2), PARP1(7), PRF1(11), RELA(4), RIPK1(3), TNF(1), TNFRSF1A(4), TNFRSF1B(4), TNFSF10(8), TRAF1(6), TRAF2(2) 14868027 159 91 157 72 94 16 11 17 21 0 0.193 1.000 1.000 301 FASPATHWAY Binding of the Fas ligand to the Fas receptor induces caspase activation and consequent apoptosis in the Fas-expressing cell. ADPRT, ARHGDIB, CASP10, CASP3, CASP6, CASP7, CASP8, CFLAR, DAXX, DFFA, DFFB, FADD, FAF1, JUN, LMNA, LMNB1, LMNB2, MAP2K4, MAP3K1, MAP3K7, MAPK8, PAK1, PAK2, PRKDC, PTPN13, RB1, RIPK2, SPTAN1, TNFRSF6, TNFSF6 27 ARHGDIB(4), CASP10(6), CASP3(2), CASP7(4), CASP8(9), CFLAR(4), DAXX(9), DFFA(2), DFFB(2), FAF1(8), JUN(1), LMNA(7), LMNB1(1), LMNB2(4), MAP2K4(4), MAP3K1(4), MAP3K7(1), MAPK8(1), PAK1(4), PAK2(7), PRKDC(19), PTPN13(15), RB1(10), RIPK2(3), SPTAN1(10) 16671963 141 91 140 75 68 12 12 25 22 2 0.857 1.000 1.000 302 GLYCOSPHINGOLIPID_METABOLISM ARSA, ARSB, ARSD, ARSE, ASAH1, GAL3ST1, GALC, GBA, GBAP, GLA, GLB1, LCT, NEU1, NEU2, NEU3, NEU4, PPAP2A, PPAP2B, PPAP2C, SMPD1, SMPD2, SPTLC1, SPTLC2, UGCG 23 ARSB(2), ARSD(3), ARSE(5), GAL3ST1(10), GALC(3), GBA(7), GLA(2), GLB1(9), LCT(51), NEU1(6), NEU2(17), NEU3(4), NEU4(16), PPAP2A(1), PPAP2B(11), PPAP2C(8), SMPD1(2), SMPD2(2), SPTLC1(1), SPTLC2(6), UGCG(1) 9784131 167 91 162 92 114 13 3 19 18 0 0.455 1.000 1.000 303 NKTPATHWAY T cell differentiation into Th1 and Th2 cells occurs by differential chemokine receptor expression, which mediates tissue localization and immune response. CCL3, CCL4, CCR1, CCR2, CCR3, CCR4, CCR5, CCR7, CD28, CD4, CSF2, CXCR3, CXCR4, IFNG, IFNGR1, IFNGR2, IL12A, IL12B, IL12RB1, IL12RB2, IL18R1, IL2, IL4, IL4R, IL5, TGFB1, TGFB2, TGFB3, TNFSF5 28 CCR1(10), CCR2(17), CCR3(10), CCR4(9), CCR5(10), CCR7(4), CD28(2), CD4(8), CSF2(2), CXCR3(4), CXCR4(3), IFNG(4), IFNGR1(3), IFNGR2(4), IL12A(4), IL12B(3), IL12RB1(15), IL12RB2(3), IL18R1(21), IL2(4), IL4(1), IL4R(16), IL5(4), TGFB1(2), TGFB2(3), TGFB3(3) 8146981 169 91 158 90 120 13 2 15 19 0 0.0273 1.000 1.000 304 CDMACPATHWAY Cadmium 2+ promotes cell proliferation in cultured macrophages by entering the cell via calcium channels and activating the MAP kinase pathway. CUZD1, FOS, HRAS, JUN, MAP2K1, MAPK1, MAPK3, MYC, NFKB1, NFKBIA, PLCB1, PRKCA, PRKCB1, RAF1, RELA, TNF 15 CUZD1(19), FOS(2), HRAS(3), JUN(1), MAP2K1(14), MAPK1(4), MAPK3(4), MYC(5), NFKB1(6), NFKBIA(2), PLCB1(54), PRKCA(8), RAF1(10), RELA(4), TNF(1) 6361753 137 90 121 56 90 9 7 17 14 0 0.0216 1.000 1.000 305 LYSINE_DEGRADATION AADAT, AASDH, AASDHPPT, AASS, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, ATP6V0C, SHMT1, BAT8, BBOX1, DLST, DLSTP, DOT1L, ECHS1, EHHADH, EHMT1, EHMT2, GCDH, HADHA, PLOD1, PLOD2, PLOD3, SDS, SHMT1, SHMT2, TMLHE 31 AADAT(5), AASDH(5), AASDHPPT(3), AASS(3), ACAT2(1), ALDH1A1(5), ALDH1A2(14), ALDH1A3(2), ALDH1B1(11), ALDH2(7), ALDH3A1(8), ALDH3A2(3), ALDH9A1(2), BBOX1(6), DOT1L(9), ECHS1(3), EHHADH(6), EHMT1(10), EHMT2(11), GCDH(6), HADHA(6), PLOD1(5), PLOD2(6), PLOD3(4), SDS(2), SHMT1(2), SHMT2(3), TMLHE(2) 15037123 150 90 144 80 91 15 7 20 17 0 0.359 1.000 1.000 306 SIG_CD40PATHWAYMAP Genes related to CD40 signaling DUSP1, GORASP1, IKBKG, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MAPKAPK5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PIK3CA, PIK3CD, PIK3R1, SYT1, TNFRSF5, TRAF2, TRAF3, TRAF5, TRAF6 32 DUSP1(1), MAP2K4(4), MAP2K7(5), MAPK1(4), MAPK10(9), MAPK11(1), MAPK12(1), MAPK13(5), MAPK14(5), MAPK3(4), MAPK8(1), MAPK8IP1(7), MAPK8IP2(7), MAPK8IP3(10), MAPK9(3), MAPKAPK5(1), NFKB1(6), NFKB2(3), NFKBIA(2), NFKBIB(1), NFKBIL1(3), PIK3CA(10), PIK3CD(8), PIK3R1(2), SYT1(23), TRAF2(2), TRAF3(5), TRAF5(8), TRAF6(4) 13655970 145 90 140 93 95 10 7 20 12 1 0.780 1.000 1.000 307 CIRCADIAN_EXERCISE ARNTL, AZIN1, BTG1, C10orf110, C1orf1, CBX3, CEBPB, CLDN5, CLOCK, CRY1, CRY2, DAZAP2, DAZAP2, LOC401029, DNAJA1, EIF4G2, ETV6, G0S2, GENX_3414, GFRA1, GSTM3, GSTP1, HERPUD1, HLA_DMA, HSPA8, IDI1, KLF9, MAP3K7IP2, MYF6, NCKAP1, NCOA4, NR1D2, OAZIN, PER1, PER2, PIGF, PPP1R3C, PPP2CB, PSMA4, PURA, SF3A3, SUMO3, TOB1, TUBB3, UCP3, UGP2, VAPA, ZFR 40 ARNTL(6), AZIN1(2), BTG1(3), CBX3(1), CLOCK(3), CRY1(6), CRY2(6), EIF4G2(4), ETV6(10), GFRA1(8), GSTM3(4), GSTP1(3), HERPUD1(2), HSPA8(5), IDI1(1), KLF9(3), MYF6(14), NCKAP1(5), NCOA4(4), NR1D2(10), PER1(8), PER2(11), PIGF(2), PPP1R3C(4), PPP2CB(2), PSMA4(2), PURA(2), SF3A3(6), TOB1(3), TUBB3(4), UCP3(6), UGP2(1), VAPA(2), ZFR(9) 14894275 162 89 160 73 84 13 15 29 21 0 0.548 1.000 1.000 308 DEATHPATHWAY Death receptors such as Fas and DR3, 4, and 5 transduce pro-apoptotic signaling by oligomerizing to activate the caspase cascade. APAF1, BCL2, BID, BIRC2, BIRC3, BIRC4, CASP10, CASP3, CASP6, CASP7, CASP8, CASP9, CFLAR, CHUK, CYCS, DFFA, DFFB, FADD, GAS2, LMNA, MAP3K14, NFKB1, NFKBIA, RELA, RIPK1, SPTAN1, TNFRSF10A, TNFRSF10B, TNFRSF25, TNFSF10, TNFSF12, TRADD, TRAF2 32 APAF1(6), BCL2(2), BIRC2(6), BIRC3(7), CASP10(6), CASP3(2), CASP7(4), CASP8(9), CASP9(2), CFLAR(4), CHUK(2), CYCS(1), DFFA(2), DFFB(2), GAS2(13), LMNA(7), MAP3K14(6), NFKB1(6), NFKBIA(2), RELA(4), RIPK1(3), SPTAN1(10), TNFRSF10A(7), TNFRSF10B(4), TNFRSF25(6), TNFSF10(8), TRAF2(2) 13631682 133 89 131 77 75 16 9 20 13 0 0.788 1.000 1.000 309 MYOSINPATHWAY Myosin light chain kinase phosphorylates myosin and promotes muscle contraction and platelet formation; myosin phosphatase antagonizes these processes. ARHGAP5, ARHGEF1, GNA12, GNA13, GNAQ, GNB1, GNGT1, MYL2, MYLK, PLCB1, PPP1R12B, PRKCA, PRKCB1, PRKCL1, ROCK1 13 ARHGAP5(13), ARHGEF1(1), GNA12(3), GNA13(1), GNAQ(6), GNB1(1), MYL2(9), MYLK(46), PLCB1(54), PPP1R12B(7), PRKCA(8), ROCK1(7) 8479941 156 89 139 68 111 3 7 18 17 0 0.115 1.000 1.000 310 SIG_IL4RECEPTOR_IN_B_LYPHOCYTES Genes related to IL4 rceptor signaling in B lymphocytes AKT1, AKT2, AKT3, BAD, BCL2, GRB2, GSK3A, GSK3B, IL4R, IRS1, IRS2, JAK1, JAK3, MAP4K1, MAPK1, MAPK3, PDK1, PIK3CA, PIK3CD, PIK3R1, PPP1R13B, RAF1, SHC1, SOCS1, SOS1, SOS2, STAT6 27 AKT1(4), AKT2(8), AKT3(3), BCL2(2), GRB2(2), GSK3A(1), GSK3B(3), IL4R(16), IRS1(5), IRS2(3), JAK1(6), JAK3(11), MAP4K1(11), MAPK1(4), MAPK3(4), PDK1(2), PIK3CA(10), PIK3CD(8), PIK3R1(2), PPP1R13B(9), RAF1(10), SHC1(2), SOCS1(1), SOS1(10), SOS2(13), STAT6(8) 14916058 158 89 157 63 88 19 6 26 18 1 0.0781 1.000 1.000 311 ATRBRCAPATHWAY BRCA1 and 2 block cell cycle progression in response to DNA damage and promote double-stranded break repair; mutations induce breast cancer susceptibility. ATM, ATR, BRCA1, BRCA2, CHEK1, CHEK2, FANCA, FANCC, FANCD2, FANCE, FANCF, FANCG, HUS1, MRE11A, NBS1, RAD1, RAD17, RAD50, RAD51, RAD9A, TP53, TREX1 20 ATM(15), ATR(23), BRCA1(15), BRCA2(22), CHEK1(2), CHEK2(2), FANCA(8), FANCC(3), FANCD2(12), FANCE(4), FANCF(1), FANCG(7), HUS1(2), MRE11A(6), RAD1(2), RAD17(6), RAD50(6), RAD9A(6), TREX1(1) 17672589 143 88 140 67 95 6 3 17 22 0 0.737 1.000 1.000 312 CBLPATHWAY Activated EGF receptors undergo endocytosis into clathrin-coated vesicles, where they are recycled to the membrane or ubiquitinated by Cbl. CBL, CSF1R, EGF, EGFR, GRB2, MET, PDGFRA, PRKCA, PRKCB1, SH3GLB1, SH3GLB2, SH3KBP1, SRC 12 CBL(10), CSF1R(13), EGF(21), EGFR(25), GRB2(2), MET(23), PDGFRA(34), PRKCA(8), SH3GLB1(2), SH3GLB2(1), SH3KBP1(6), SRC(2) 7958810 147 88 145 87 94 11 5 18 19 0 0.818 1.000 1.000 313 HSA00020_CITRATE_CYCLE Genes involved in citrate cycle (TCA cycle) ACLY, ACO1, ACO2, CLYBL, CS, DLD, DLST, FH, IDH1, IDH2, IDH3A, IDH3B, IDH3G, LOC283398, LOC441996, MDH1, MDH2, OGDH, OGDHL, PC, PCK1, PCK2, SDHA, SDHB, SDHC, SDHD, SUCLA2, SUCLG1, SUCLG2 26 ACLY(10), ACO1(6), ACO2(5), CLYBL(5), CS(2), DLD(3), FH(3), IDH2(1), IDH3A(3), IDH3B(2), IDH3G(2), MDH1(3), MDH2(3), OGDH(8), OGDHL(42), PC(14), PCK1(25), PCK2(6), SDHA(3), SDHC(3), SDHD(1), SUCLG1(3), SUCLG2(2) 11895767 155 88 150 87 104 4 6 22 19 0 0.380 1.000 1.000 314 REELINPATHWAY Reelin is secreted by neurons and recognized by receptors including cadherin related neuronal receptors, which promote phosphorylation of Dab1. CDK5, CDK5R1, DAB1, FYN, LRP8, RELN, VLDLR 7 CDK5(6), CDK5R1(1), DAB1(45), FYN(7), LRP8(3), RELN(88), VLDLR(5) 5710823 155 88 149 84 112 9 3 12 18 1 0.833 1.000 1.000 315 G1PATHWAY CDK4/6-cyclin D and CDK2-cyclin E phosphorylate Rb, which allows the transcription of genes needed for the G1/S cell cycle transition. ABL1, ATM, ATR, CCNA1, CCND1, CCNE1, CDC2, CDC25A, CDK2, CDK4, CDK6, CDKN1A, CDKN1B, CDKN2A, CDKN2B, DHFR, E2F1, GSK3B, HDAC1, MADH3, MADH4, RB1, SKP2, TFDP1, TGFB1, TGFB2, TGFB3, TP53 23 ABL1(13), ATM(15), ATR(23), CCNA1(14), CCND1(2), CCNE1(4), CDC25A(8), CDK4(7), CDK6(2), CDKN1A(3), CDKN1B(1), DHFR(2), E2F1(5), GSK3B(3), HDAC1(2), RB1(10), SKP2(2), TFDP1(2), TGFB1(2), TGFB2(3), TGFB3(3) 11724613 126 87 122 51 72 8 9 16 19 2 0.179 1.000 1.000 316 HSA00531_GLYCOSAMINOGLYCAN_DEGRADATION Genes involved in glycosaminoglycan degradation ARSB, GALNS, GLB1, GNS, GUSB, HEXA, HEXB, HGSNAT, HPSE, HPSE2, HYAL1, HYAL2, IDS, IDUA, LCT, NAGLU, SPAM1 17 ARSB(2), GALNS(5), GLB1(9), GNS(1), GUSB(5), HEXA(6), HEXB(4), HGSNAT(5), HPSE(10), HPSE2(5), HYAL1(2), HYAL2(1), IDS(9), IDUA(4), LCT(51), NAGLU(4), SPAM1(27) 8304819 150 87 147 81 110 8 3 13 16 0 0.352 1.000 1.000 317 LYMPHOCYTEPATHWAY B and T cell lymphocytes interact with other cells via transmembrane adhesion proteins such as CD44, which interacts with endothelial cells. CD44, ICAM1, ITGA4, ITGAL, ITGB1, ITGB2, PECAM1, SELE, SELL 9 CD44(5), ICAM1(2), ITGA4(43), ITGAL(28), ITGB1(4), ITGB2(16), SELE(33), SELL(10) 4902262 141 87 136 47 102 4 5 11 19 0 0.00434 1.000 1.000 318 MPRPATHWAY Progesterone binding to its intracellular receptor activates the MAPK pathway and induces oocyte maturation; binding to membrane receptor inhibits adenylyl cyclase. ACTA1, ADCY1, CAP1, CCNB1, CDC2, CDC25C, GNAI1, GNAS, GNB1, GNGT1, HRAS, MAPK1, MAPK3, MYT1, PIN1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RPS6KA1, SRC 22 ACTA1(4), ADCY1(34), CAP1(2), CDC25C(5), GNAI1(2), GNAS(25), GNB1(1), HRAS(3), MAPK1(4), MAPK3(4), MYT1(21), PIN1(1), PRKACB(4), PRKACG(11), PRKAR1A(3), PRKAR1B(4), PRKAR2A(1), PRKAR2B(5), RPS6KA1(8), SRC(2) 8384422 144 87 139 93 93 15 8 14 14 0 0.761 1.000 1.000 319 EPHA4PATHWAY Eph Kinases and ephrins support platelet aggregation ACTA1, EPHA4, EPHB1, FYN, ITGA1, ITGB1, L1CAM, LYN, RAP1B, SELP 10 ACTA1(4), EPHA4(21), EPHB1(29), FYN(7), ITGA1(24), ITGB1(4), L1CAM(11), LYN(10), RAP1B(1), SELP(39) 6445451 150 86 138 70 107 6 3 17 17 0 0.145 1.000 1.000 320 GLUTAMATE_METABOLISM ABAT, ALDH4A1, ALDH5A1, CAD, CPS1, EPRS, GAD1, GAD2, GCLC, GCLM, GFPT1, GLS, GLS2, GLUD1, GLUL, GMPS, GOT1, GOT2, GPT, GPT2, GSS, NADSYN1, PPAT, QARS 24 ABAT(9), ALDH4A1(6), ALDH5A1(10), CAD(18), CPS1(26), EPRS(13), GAD1(13), GAD2(9), GCLC(5), GCLM(2), GFPT1(4), GLS(2), GLS2(3), GLUD1(2), GLUL(2), GMPS(6), GOT1(6), GOT2(6), GPT(3), GPT2(2), GSS(8), NADSYN1(4), QARS(6) 13565485 165 86 158 82 97 18 9 24 17 0 0.292 1.000 1.000 321 HSA00624_1_AND_2_METHYLNAPHTHALENE_DEGRADATION Genes involved in 1- and 2-methylnaphthalene degradation ACAD8, ACAD9, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ARD1A, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ESCO1, ESCO2, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1 22 ACAD8(3), ACAD9(2), ADH1A(17), ADH1B(30), ADH1C(1), ADH4(10), ADH5(3), ADH6(14), ADH7(16), ADHFE1(6), DHRS1(3), DHRS2(8), DHRS3(4), DHRS7(1), DHRSX(6), ESCO1(2), ESCO2(4), PNPLA3(3), SH3GLB1(2) 10230118 135 86 118 53 98 9 7 14 7 0 0.0576 1.000 1.000 322 IL2PATHWAY IL-2 promotes proliferation via JAK and MAP kinase and has surface receptors on activated B cells, LPS-treated monocytes, and many T cells. CSNK2A1, ELK1, FOS, GRB2, HRAS, IL2, IL2RA, IL2RB, IL2RG, JAK1, JAK3, JUN, LCK, MAP2K1, MAPK3, MAPK8, RAF1, SHC1, SOS1, STAT5A, STAT5B, SYK 22 CSNK2A1(4), ELK1(3), FOS(2), GRB2(2), HRAS(3), IL2(4), IL2RA(5), IL2RB(12), IL2RG(3), JAK1(6), JAK3(11), JUN(1), LCK(15), MAP2K1(14), MAPK3(4), MAPK8(1), RAF1(10), SHC1(2), SOS1(10), STAT5A(3), STAT5B(6), SYK(14) 9404817 135 86 127 63 78 12 6 25 14 0 0.237 1.000 1.000 323 NKCELLSPATHWAY Natural killer (NK) lymphocytes are inhibited by MHC and activated by surface glycoproteins on tumor or virus-infected cells, which undergo perforin-mediated lysis. B2M, HLA-A, IL18, ITGB1, KLRC1, KLRC2, KLRC3, KLRC4, KLRD1, LAT, MAP2K1, MAPK3, PAK1, PIK3CA, PIK3R1, PTK2B, PTPN6, RAC1, SYK, VAV1 19 B2M(4), HLA-A(3), IL18(3), ITGB1(4), KLRC1(4), KLRC2(14), KLRC4(6), KLRD1(5), LAT(2), MAP2K1(14), MAPK3(4), PAK1(4), PIK3CA(10), PIK3R1(2), PTK2B(10), PTPN6(5), SYK(14), VAV1(19) 7400142 127 86 115 76 89 5 2 12 18 1 0.822 1.000 1.000 324 O_GLYCAN_BIOSYNTHESIS GALNT1, GALNT10, GALNT2, GALNT3, GALNT4, GALNT6, GALNT7, GALNT8, GALNT9, GCNT1, SIAT4A, SIAT4B, ST3GAL1, ST3GAL2, ST3GAL4, WBSCR17 14 GALNT1(4), GALNT10(7), GALNT2(6), GALNT3(4), GALNT4(5), GALNT6(17), GALNT7(4), GALNT8(27), GALNT9(7), GCNT1(6), ST3GAL1(7), ST3GAL2(1), ST3GAL4(2), WBSCR17(44) 5920927 141 86 130 63 101 8 3 14 15 0 0.0748 1.000 1.000 325 PLCEPATHWAY Gs-coupled receptors activate adenylyl cyclase, which activates Epac1, leading to the stimulation of PLC and subsequent DAG and IP3 production. ADCY1, ADRB2, GNAS, PLCE1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTGER1, RAP2B 11 ADCY1(34), ADRB2(3), GNAS(25), PLCE1(57), PRKACB(4), PRKACG(11), PRKAR1A(3), PRKAR1B(4), PRKAR2A(1), PRKAR2B(5) 5979383 147 86 140 76 92 17 9 15 14 0 0.378 1.000 1.000 326 VIPPATHWAY Apoptosis of activated T cells is inhibited by vasoactive intestinal peptide (VIP) and its relative PACAP. CALM1, CALM2, CALM3, CHUK, EGR2, EGR3, GNAQ, MAP3K1, MYC, NFATC1, NFATC2, NFKB1, NFKBIA, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RELA, SYT1, VIP, VIPR2 27 CALM1(1), CALM2(1), CHUK(2), EGR2(5), EGR3(4), GNAQ(6), MAP3K1(4), MYC(5), NFATC1(16), NFATC2(11), NFKB1(6), NFKBIA(2), PLCG1(8), PPP3CA(5), PPP3CB(3), PPP3CC(2), PRKACB(4), PRKACG(11), PRKAR1A(3), PRKAR1B(4), PRKAR2A(1), PRKAR2B(5), RELA(4), SYT1(23), VIP(5), VIPR2(7) 11391341 148 86 142 89 93 12 9 15 19 0 0.840 1.000 1.000 327 CFTRPATHWAY The cAMP-regulated chloride channel CFTR (deficient in cystic fibrosis) is regulated by the surface-localized beta-adrenergic receptor. ADCY1, ADRB2, CFTR, GNAS, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, SLC9A3R1, VIL2 11 ADCY1(34), ADRB2(3), CFTR(60), GNAS(25), PRKACB(4), PRKACG(11), PRKAR1A(3), PRKAR1B(4), PRKAR2A(1), PRKAR2B(5), SLC9A3R1(2) 5302059 152 85 140 90 99 14 6 14 18 1 0.619 1.000 1.000 328 MRPPATHWAY Cancer cells resistant to numerous drugs are called multidrug-resistant (MDR) and express ATP-binding cassette transporter proteins that pump the drugs out of cells. ABCB1, ABCB11, ABCB4, ABCC1, ABCC3, GSTP1 6 ABCB1(39), ABCB11(49), ABCB4(21), ABCC1(15), ABCC3(29), GSTP1(3) 5812990 156 85 144 73 104 16 5 12 19 0 0.00159 1.000 1.000 329 NTHIPATHWAY Hemophilus influenzae infections activate NF-kB via several pathways, inducing the inflammatory response. CHUK, CREBBP, DUSP1, EP300, IKBKB, IL1B, IL8, MADH3, MADH4, MAP2K3, MAP2K6, MAP3K14, MAP3K7, MAPK11, MAPK14, MYD88, NFKB1, NFKBIA, NR3C1, RELA, TGFBR1, TGFBR2, TLR2, TNF 22 CHUK(2), CREBBP(24), DUSP1(1), EP300(18), IKBKB(4), IL1B(8), IL8(1), MAP2K3(8), MAP2K6(3), MAP3K14(6), MAP3K7(1), MAPK11(1), MAPK14(5), MYD88(3), NFKB1(6), NFKBIA(2), NR3C1(7), RELA(4), TGFBR2(9), TLR2(15), TNF(1) 12128129 129 85 128 72 77 19 6 17 10 0 0.817 1.000 1.000 330 RNA_TRANSCRIPTION_REACTOME CCNH, CDK7, ERCC3, GTF2A2, GTF2B, GTF2E1, GTF2E2, GTF2F2, GTF2H1, GTF2H2, GTF2H4, ILK, MGC9850, MNAT1, POLR1A, POLR1B, POLR2A, POLR2B, POLR2C, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR3B, POLR3D, POLR3E, POLR3H, POLR3K, TAF12, TAF13, TAF5, TAF6, TAF7, TAF9, TBP, VARS2L 36 CCNH(2), CDK7(2), ERCC3(6), GTF2A2(1), GTF2B(4), GTF2E1(3), GTF2E2(5), GTF2F2(2), GTF2H1(3), GTF2H4(2), ILK(2), MNAT1(2), POLR1A(13), POLR1B(9), POLR2A(13), POLR2B(12), POLR2C(1), POLR2E(3), POLR2F(1), POLR2H(2), POLR2J(1), POLR3B(14), POLR3D(1), POLR3E(4), POLR3H(1), POLR3K(1), TAF13(2), TAF6(4), TAF7(2), TBP(4) 14353367 122 85 119 54 74 9 9 18 12 0 0.253 1.000 1.000 331 TELPATHWAY Telomerase is a ribonucleotide protein that adds telomeric repeats to the 3' ends of chromosomes. AKT1, BCL2, EGFR, G22P1, HSPCA, IGF1R, KRAS2, MYC, POLR2A, PPP2CA, PRKCA, RB1, TEP1, TERF1, TERT, TNKS, TP53, XRCC5 14 AKT1(4), BCL2(2), EGFR(25), IGF1R(14), MYC(5), POLR2A(13), PRKCA(8), RB1(10), TEP1(34), TERF1(2), TERT(9), TNKS(9), XRCC5(2) 11155606 137 85 133 77 81 13 8 15 18 2 0.554 1.000 1.000 332 HSA00511_N_GLYCAN_DEGRADATION Genes involved in N-glycan degradation AGA, FLJ21865, FUCA1, FUCA2, GLB1, HEXA, HEXB, LCT, MAN2B1, MAN2B2, MAN2C1, MANBA, NEU1, NEU2, NEU3, NEU4 15 AGA(4), FUCA1(3), GLB1(9), HEXA(6), HEXB(4), LCT(51), MAN2B1(8), MAN2B2(10), MAN2C1(7), MANBA(8), NEU1(6), NEU2(17), NEU3(4), NEU4(16) 8287320 153 84 150 68 112 13 2 14 12 0 0.0337 1.000 1.000 333 DNA_REPLICATION_REACTOME ASK, CDC45L, CDC6, CDC7, CDK2, CDT1, DIAPH2, GMNN, MCM10, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, NACA, NACA, FKSG17, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, POLA, POLA2, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, PRIM1, PRIM2A, RFC1, RFC2, RFC3, RFC4, RFC5, RPA1, RPA2, RPA3, RPA4, RPS27A, RPS27A, LOC388720, LOC389425, UBA52, UBB, UBC 42 CDC6(2), CDC7(2), CDT1(3), DIAPH2(6), MCM10(7), MCM2(11), MCM3(9), MCM4(8), MCM5(5), MCM6(5), MCM7(1), PCNA(2), POLA2(8), POLD1(7), POLD2(2), POLD3(7), POLE(16), POLE2(2), PRIM1(2), RFC1(5), RFC2(3), RFC3(1), RPA1(3), RPA2(1), RPA4(2), UBC(13) 20651559 133 83 131 90 83 9 8 17 16 0 0.959 1.000 1.000 334 ETSPATHWAY The Ets transcription factors are activated by Ras and promote macrophage differentiation. CSF1, CSF1R, DDX20, E2F1, E2F4, ETS1, ETS2, ETV3, FOS, HDAC2, HDAC5, HRAS, JUN, NCOR2, RBL1, RBL2, SIN3A, SIN3B 18 CSF1(12), CSF1R(13), DDX20(11), E2F1(5), E2F4(3), ETS1(4), ETS2(8), ETV3(3), FOS(2), HDAC2(2), HDAC5(6), HRAS(3), JUN(1), NCOR2(26), RBL1(12), RBL2(6), SIN3A(11), SIN3B(8) 10597316 136 83 136 69 88 7 3 26 12 0 0.324 1.000 1.000 335 HSA00030_PENTOSE_PHOSPHATE_PATHWAY Genes involved in pentose phosphate pathway ALDOA, ALDOB, ALDOC, DERA, FBP1, FBP2, G6PD, GPI, H6PD, PFKL, PFKM, PFKP, PGD, PGLS, PGM1, PGM3, PRPS1, PRPS1L1, PRPS2, RBKS, RPE, RPIA, TALDO1, TKT, TKTL1, TKTL2 26 ALDOA(2), ALDOB(14), ALDOC(4), DERA(2), FBP1(3), FBP2(2), G6PD(3), GPI(3), H6PD(7), PFKL(4), PFKM(2), PFKP(2), PGD(9), PGLS(2), PGM1(6), PGM3(1), PRPS1(2), PRPS1L1(13), PRPS2(2), RBKS(4), TALDO1(3), TKT(6), TKTL1(3), TKTL2(26) 9897560 125 83 118 82 84 11 7 8 15 0 0.424 1.000 1.000 336 STILBENE_COUMARINE_AND_LIGNIN_BIOSYNTHESIS EPX, GBA3, LPO, MPO, PRDX1, PRDX2, PRDX5, PRDX6, TPO, TYR 10 EPX(9), GBA3(19), LPO(20), MPO(11), PRDX1(3), PRDX2(3), PRDX6(4), TPO(47), TYR(9) 3944727 125 83 118 65 92 13 1 6 13 0 0.0956 1.000 1.000 337 WNTPATHWAY The Wnt glycoprotein binds to membrane-bound receptors such as Frizzled to activate a number of signaling pathways, including that of beta-catenin. APC, AXIN1, BTRC, CCND1, CREBBP, CSNK1A1, CSNK1D, CSNK2A1, CTBP1, CTNNB1, DVL1, FRAT1, FZD1, GSK3B, HDAC1, MADH4, MAP3K7, MAP3K7IP1, MYC, NLK, PPARD, PPP2CA, TCF1, TLE1, WIF1, WNT1 22 APC(25), AXIN1(9), BTRC(4), CCND1(2), CREBBP(24), CSNK1A1(3), CSNK1D(3), CSNK2A1(4), CTNNB1(14), FZD1(5), GSK3B(3), HDAC1(2), MAP3K7(1), MYC(5), NLK(5), PPARD(3), TLE1(4), WIF1(7), WNT1(2) 11915969 125 83 123 63 60 11 10 21 23 0 0.807 1.000 1.000 338 GLEEVECPATHWAY The drug Gleevec specifically targets the abnormal bcr-abl protein, an apoptosis inhibitor present in chronic myeloid leukemia. AKT1, BCL2, BCR, CRKL, FOS, GRB2, HRAS, JAK2, JUN, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, MYC, PIK3CA, PIK3R1, RAF1, SOS1, STAT1, STAT5A, STAT5B 22 AKT1(4), BCL2(2), BCR(15), CRKL(3), FOS(2), GRB2(2), HRAS(3), JAK2(8), JUN(1), MAP2K1(14), MAP2K4(4), MAP3K1(4), MAPK3(4), MAPK8(1), MYC(5), PIK3CA(10), PIK3R1(2), RAF1(10), SOS1(10), STAT1(5), STAT5A(3), STAT5B(6) 11423224 118 82 110 50 59 13 8 23 14 1 0.339 1.000 1.000 339 HSA00530_AMINOSUGARS_METABOLISM Genes involved in aminosugars metabolism AMDHD2, CHIA, CHIT1, CMAS, CTBS, CYB5R1, CYB5R3, GFPT1, GFPT2, GNE, GNPDA1, GNPDA2, GNPNAT1, HEXA, HEXB, HK1, HK2, HK3, LHPP, MTMR1, MTMR2, MTMR6, NAGK, NANS, NPL, PGM3, PHPT1, RENBP, UAP1 29 AMDHD2(4), CHIA(10), CHIT1(12), CMAS(2), CTBS(5), CYB5R1(2), CYB5R3(2), GFPT1(4), GFPT2(8), GNE(3), GNPDA1(1), GNPDA2(1), HEXA(6), HEXB(4), HK1(3), HK2(13), HK3(14), LHPP(1), MTMR1(5), MTMR2(2), MTMR6(2), NAGK(1), NANS(1), NPL(1), PGM3(1), RENBP(4), UAP1(2) 11700907 114 82 112 67 71 10 6 16 11 0 0.713 1.000 1.000 340 HSA00565_ETHER_LIPID_METABOLISM Genes involved in ether lipid metabolism AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPAT6, AGPS, CHPT1, ENPP2, ENPP6, LYCAT, PAFAH1B1, PAFAH1B2, PAFAH1B3, PAFAH2, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLD1, PLD2, PPAP2A, PPAP2B, PPAP2C 30 AGPAT1(1), AGPAT2(2), AGPAT3(6), AGPAT4(6), AGPAT6(3), AGPS(4), CHPT1(1), ENPP2(2), ENPP6(13), PAFAH1B1(4), PAFAH1B2(2), PAFAH1B3(1), PAFAH2(2), PLA2G12B(4), PLA2G1B(1), PLA2G2A(2), PLA2G2D(5), PLA2G2E(5), PLA2G2F(6), PLA2G3(17), PLA2G4A(15), PLA2G5(2), PLA2G6(12), PLD1(13), PLD2(8), PPAP2A(1), PPAP2B(11), PPAP2C(8) 9515789 157 82 151 75 99 11 5 16 25 1 0.135 1.000 1.000 341 HSA03030_DNA_POLYMERASE Genes involved in DNA polymerase POLA1, POLA2, POLB, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, POLE3, POLE4, POLG, POLG2, POLH, POLI, POLK, POLL, POLM, POLQ, POLS, PRIM1, PRIM2, REV1, REV3L, RFC5 23 POLA1(3), POLA2(8), POLB(1), POLD1(7), POLD2(2), POLD3(7), POLE(16), POLE2(2), POLG(9), POLG2(7), POLH(5), POLI(2), POLK(7), POLL(8), POLM(2), POLQ(25), PRIM1(2), REV1(3), REV3L(18) 16167521 134 82 133 63 72 9 11 25 17 0 0.619 1.000 1.000 342 IRINOTECAN_PATHWAY_PHARMGKB ABCC1, ABCC2, ABCG2, BCHE, CES1, CES2, CES4, CYP3A4, CYP3A5, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6 17 ABCC1(15), ABCC2(11), ABCG2(6), BCHE(8), CES1(21), CES2(4), CYP3A4(20), UGT1A1(77) 9358699 162 82 151 67 114 13 5 13 17 0 0.00111 1.000 1.000 343 PGC1APATHWAY PCG-1a is expressed in skeletal muscle, heart muscle, and brown fat, and is a coactivator for receptors such as glucocorticoid receptor and thyroid hormone receptor. CALM1, CALM2, CALM3, CAMK1, CAMK1G, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, ESRRA, HDAC5, MEF2A, MEF2B, MEF2C, MEF2D, PPARA, PPARGC1, PPP3CA, PPP3CB, PPP3CC, SLC2A4, SYT1, YWHAH 23 CALM1(1), CALM2(1), CAMK1(5), CAMK1G(11), CAMK2A(6), CAMK2B(6), CAMK2D(6), CAMK2G(5), CAMK4(17), ESRRA(3), HDAC5(6), MEF2A(3), MEF2B(2), MEF2C(4), MEF2D(6), PPARA(7), PPP3CA(5), PPP3CB(3), PPP3CC(2), SLC2A4(9), SYT1(23) 8189583 131 82 124 73 95 8 5 11 12 0 0.311 1.000 1.000 344 ST_ERK1_ERK2_MAPK_PATHWAY The Erk1 and Erk2 MAP kinase pathways are regulated by Raf, Mos, and Tpl-2. ARAF1, ATF1, BAD, BRAF, COPEB, CREB1, CREB3, CREB5, DUSP4, DUSP6, DUSP9, EEF2K, EIF4E, GRB2, HTATIP, MAP2K1, MAP2K2, MAP3K8, MAPK1, MAPK3, MKNK1, MKNK2, MOS, NFKB1, RAP1A, RPS6KA1, RPS6KA2, RPS6KA3, SHC1, SOS1, SOS2, TRAF3 28 ATF1(4), CREB3(1), CREB5(9), DUSP4(2), DUSP6(2), DUSP9(3), EEF2K(6), GRB2(2), MAP2K1(14), MAP2K2(5), MAPK1(4), MAPK3(4), MKNK1(6), MKNK2(3), MOS(6), NFKB1(6), RAP1A(2), RPS6KA1(8), RPS6KA2(6), RPS6KA3(1), SHC1(2), SOS1(10), SOS2(13), TRAF3(5) 11390479 124 82 115 73 81 11 4 15 13 0 0.878 1.000 1.000 345 CARDIACEGFPATHWAY Cardiac hypertrophy, a response to high blood pressure, is stimulated by GPCR ligands such as angiotensin II that activate the EGF pathway. ADAM12, AGT, AGTR2, ARHA, EDN1, EDNRA, EDNRB, EGF, EGFR, FOS, HRAS, JUN, MYC, NFKB1, PLCG1, PRKCA, PRKCB1, RELA 16 ADAM12(12), AGT(8), AGTR2(9), EDN1(9), EDNRA(10), EDNRB(7), EGF(21), EGFR(25), FOS(2), HRAS(3), JUN(1), MYC(5), NFKB1(6), PLCG1(8), PRKCA(8), RELA(4) 8385930 138 81 135 73 92 11 8 12 15 0 0.297 1.000 1.000 346 CK1PATHWAY Caseine kinase 1 (CK1) and cdk5 phosphorylate DARPP32 in the dopamine signaling pathway. CDK5, CDK5R1, CSNK1D, DRD1, DRD2, GRM1, PLCB1, PPP1CA, PPP1R1B, PPP2CA, PPP3CA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B 17 CDK5(6), CDK5R1(1), CSNK1D(3), DRD1(9), DRD2(14), GRM1(16), PLCB1(54), PPP1CA(1), PPP1R1B(2), PPP3CA(5), PRKACB(4), PRKACG(11), PRKAR1A(3), PRKAR1B(4), PRKAR2A(1), PRKAR2B(5) 6511981 139 81 131 90 102 3 5 14 15 0 0.677 1.000 1.000 347 TNFR1PATHWAY Tumor necrosis factor alpha binds to its receptor TNFR1 and induces caspase-dependent apoptosis. ADPRT, ARHGDIB, BAG4, CASP2, CASP3, CASP8, CRADD, DFFA, DFFB, FADD, JUN, LMNA, LMNB1, LMNB2, MADD, MAP2K4, MAP3K1, MAP3K7, MAPK8, PAK1, PAK2, PRKDC, RB1, RIPK1, SPTAN1, TNF, TNFRSF1A, TRADD, TRAF2 28 ARHGDIB(4), BAG4(3), CASP2(1), CASP3(2), CASP8(9), CRADD(2), DFFA(2), DFFB(2), JUN(1), LMNA(7), LMNB1(1), LMNB2(4), MADD(19), MAP2K4(4), MAP3K1(4), MAP3K7(1), MAPK8(1), PAK1(4), PAK2(7), PRKDC(19), RB1(10), RIPK1(3), SPTAN1(10), TNF(1), TNFRSF1A(4), TRAF2(2) 15858323 127 81 125 64 64 10 12 18 21 2 0.520 1.000 1.000 348 HSA00960_ALKALOID_BIOSYNTHESIS_II Genes involved in alkaloid biosynthesis II AADAC, ABP1, AOC2, AOC3, ARD1A, CES1, CES7, DDHD1, ESCO1, ESCO2, LIPA, LYCAT, MYST3, MYST4, NAT5, NAT6, PLA1A, PNPLA3, PPME1, PRDX6, SH3GLB1 18 AADAC(15), ABP1(22), AOC2(9), AOC3(10), CES1(21), DDHD1(7), ESCO1(2), ESCO2(4), LIPA(5), PLA1A(10), PNPLA3(3), PPME1(1), PRDX6(4), SH3GLB1(2) 10357820 115 80 111 62 86 4 9 7 9 0 0.645 1.000 1.000 349 TGFBPATHWAY The TGF-beta receptor responds to ligand binding by activating the SMAD family of transcriptional regulations, commonly blocking cell growth. APC, CDH1, CREBBP, EP300, MADH2, MADH3, MADH4, MADH7, MADHIP, MAP2K1, MAP3K7, MAP3K7IP1, MAPK3, SKIL, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2 13 APC(25), CDH1(5), CREBBP(24), EP300(18), MAP2K1(14), MAP3K7(1), MAPK3(4), SKIL(3), TGFB1(2), TGFB2(3), TGFB3(3), TGFBR2(9) 10516324 111 80 104 48 59 12 7 19 14 0 0.612 1.000 1.000 350 EGFR_SMRTEPATHWAY EGF receptor activation inhibits SMRT, a transcriptional co-repressor that interacts with transcription factor complexes and gene silencers. EGF, EGFR, MAP2K1, MAP3K1, MAPK14, NCOR2, RARA, RXRA, THRA, THRB, ZNF145 10 EGF(21), EGFR(25), MAP2K1(14), MAP3K1(4), MAPK14(5), NCOR2(26), RARA(4), RXRA(4), THRA(2), THRB(18) 7006443 123 79 115 59 81 11 3 14 14 0 0.259 1.000 1.000 351 SHHPATHWAY Sonic hedgehog (Shh) signaling in the developing CNS induces neuronal proliferation via interaction with the patched (Ptc-1) and smoothened receptors. DYRK1A, DYRK1B, GLI, GLI2, GLI3, GSK3B, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTCH, SHH, SMO, SUFU 14 DYRK1A(4), DYRK1B(2), GLI2(42), GLI3(18), GSK3B(3), PRKACB(4), PRKACG(11), PRKAR1A(3), PRKAR1B(4), PRKAR2A(1), PRKAR2B(5), SHH(3), SMO(10), SUFU(2) 6782782 112 79 109 67 75 11 6 9 11 0 0.601 1.000 1.000 352 CHREBPPATHWAY Carbohydrate responsive element binding protein (chREBP) is a transcription factor inhibited by cAMP and activated by high carbohydrate levels. ADCY1, BG1, BUCS1, GNAS, GNB1, GNGT1, PPP2CA, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKACB, PRKACG, PRKAG1, PRKAG2, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, WBSCR14 17 ADCY1(34), GNAS(25), GNB1(1), PRKAA1(1), PRKAA2(30), PRKAB1(2), PRKAB2(2), PRKACB(4), PRKACG(11), PRKAG1(3), PRKAG2(8), PRKAR1A(3), PRKAR1B(4), PRKAR2A(1), PRKAR2B(5) 6245452 134 78 128 65 87 14 7 9 17 0 0.300 1.000 1.000 353 GABAPATHWAY Gamma-aminobutyric acid (GABA) is an inhibitory neurotransmitter whose receptor is regulated by Plic-1, gephyrin, and GABARAP, which promote receptor clustering. DNM1, GABARAP, GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GPHN, NSF, SRC, UBQLN1 12 DNM1(9), GABRA1(18), GABRA2(18), GABRA3(22), GABRA4(15), GABRA5(4), GABRA6(28), GPHN(8), SRC(2), UBQLN1(5) 4798579 129 78 113 69 96 6 4 11 10 2 0.349 1.000 1.000 354 HSA00480_GLUTATHIONE_METABOLISM Genes involved in glutathione metabolism ANPEP, G6PD, GCLC, GCLM, GGT1, GGTL3, GGTL4, GPX1, GPX2, GPX3, GPX4, GPX5, GPX6, GPX7, GSR, GSS, GSTA1, GSTA2, GSTA3, GSTA4, GSTA5, GSTK1, GSTM1, GSTM2, GSTM3, GSTM4, GSTM5, GSTO2, GSTP1, GSTT1, GSTT2, GSTZ1, IDH1, IDH2, MGST1, MGST2, MGST3, OPLAH, TXNDC12 35 ANPEP(24), G6PD(3), GCLC(5), GCLM(2), GGT1(8), GPX1(3), GPX3(4), GPX5(17), GPX6(16), GSR(2), GSS(8), GSTA1(6), GSTA2(3), GSTA3(1), GSTA4(1), GSTA5(3), GSTK1(3), GSTM1(2), GSTM3(4), GSTM4(2), GSTM5(6), GSTO2(1), GSTP1(3), GSTT1(1), GSTZ1(1), IDH2(1), MGST1(2), MGST2(2), MGST3(1), OPLAH(12), TXNDC12(1) 8585869 148 78 141 81 100 10 7 19 12 0 0.0833 1.000 1.000 355 HSA00940_PHENYLPROPANOID_BIOSYNTHESIS Genes involved in phenylpropanoid biosynthesis EPX, GBA, GBA3, LPO, MPO, PRDX6, TPO 7 EPX(9), GBA(7), GBA3(19), LPO(20), MPO(11), PRDX6(4), TPO(47) 3424790 117 78 110 65 87 12 1 7 10 0 0.127 1.000 1.000 356 IL12PATHWAY IL12 and Stat4 Dependent Signaling Pathway in Th1 Development CCR5, CD3D, CD3E, CD3G, CD3Z, CXCR3, ETV5, IFNG, IL12A, IL12B, IL12RB1, IL12RB2, IL18, IL18R1, JAK2, JUN, MAP2K6, MAPK14, MAPK8, STAT4, TRA@, TRB@, TYK2 20 CCR5(10), CD3D(7), CD3E(2), CD3G(1), CXCR3(4), ETV5(7), IFNG(4), IL12A(4), IL12B(3), IL12RB1(15), IL12RB2(3), IL18(3), IL18R1(21), JAK2(8), JUN(1), MAP2K6(3), MAPK14(5), MAPK8(1), STAT4(26), TYK2(8) 7574942 136 78 131 62 94 8 4 14 16 0 0.188 1.000 1.000 357 INSULINPATHWAY Insulin regulates glucose levels via Ras-mediated transcriptional activation. CSNK2A1, ELK1, FOS, GRB2, HRAS, INS, INSR, IRS1, JUN, MAP2K1, MAPK3, MAPK8, PIK3CA, PIK3R1, PTPN11, RAF1, RASA1, SHC1, SLC2A4, SOS1, SRF 21 CSNK2A1(4), ELK1(3), FOS(2), GRB2(2), HRAS(3), INSR(26), IRS1(5), JUN(1), MAP2K1(14), MAPK3(4), MAPK8(1), PIK3CA(10), PIK3R1(2), PTPN11(10), RAF1(10), RASA1(4), SHC1(2), SLC2A4(9), SOS1(10), SRF(3) 10455492 125 78 113 57 55 16 6 36 11 1 0.665 1.000 1.000 358 TPOPATHWAY Thrombopoietin binds to its receptor and activates cell growth through the Erk and JNK MAP kinase pathways, protein kinase C, and JAK/STAT activation. CSNK2A1, FOS, GRB2, HRAS, JAK2, JUN, MAP2K1, MAPK3, MPL, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, RAF1, RASA1, SHC1, SOS1, STAT1, STAT3, STAT5A, STAT5B, THPO 22 CSNK2A1(4), FOS(2), GRB2(2), HRAS(3), JAK2(8), JUN(1), MAP2K1(14), MAPK3(4), MPL(8), PIK3CA(10), PIK3R1(2), PLCG1(8), PRKCA(8), RAF1(10), RASA1(4), SHC1(2), SOS1(10), STAT1(5), STAT3(9), STAT5A(3), STAT5B(6), THPO(9) 12206830 132 78 123 62 70 13 8 29 11 1 0.654 1.000 1.000 359 ALANINE_AND_ASPARTATE_METABOLISM AARS, ABAT, ADSL, ADSS, AGXT, AGXT2, ASL, ASNS, ASPA, ASS, CAD, CRAT, DARS, DDO, GAD1, GAD2, GOT1, GOT2, GPT, GPT2, NARS, PC 20 AARS(5), ABAT(9), ADSL(5), ADSS(1), AGXT(10), ASL(6), ASNS(8), ASPA(3), CAD(18), CRAT(5), DARS(4), DDO(8), GAD1(13), GAD2(9), GOT1(6), GOT2(6), GPT(3), GPT2(2), NARS(2), PC(14) 10267914 137 77 133 85 93 15 8 10 11 0 0.458 1.000 1.000 360 HSA00910_NITROGEN_METABOLISM Genes involved in nitrogen metabolism AMT, ASNS, ASRGL1, CA1, CA12, CA13, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA8, CA9, CPS1, CTH, GLS, GLS2, GLUD1, GLUD2, GLUL, HAL 24 AMT(1), ASNS(8), ASRGL1(6), CA1(9), CA12(3), CA13(5), CA2(12), CA3(6), CA4(3), CA5A(3), CA5B(1), CA6(4), CA7(2), CA8(6), CA9(8), CPS1(26), CTH(1), GLS(2), GLS2(3), GLUD1(2), GLUD2(4), GLUL(2), HAL(14) 8611669 131 77 126 64 92 9 4 14 12 0 0.272 1.000 1.000 361 IGF1PATHWAY Growth factor IGF-1 stimulates growth and inhibits apoptosis by activating the MAP kinase pathway in a variety of cell types. CSNK2A1, ELK1, FOS, GRB2, HRAS, IGF1, IGF1R, IRS1, JUN, MAP2K1, MAPK3, MAPK8, PIK3CA, PIK3R1, PTPN11, RAF1, RASA1, SHC1, SOS1, SRF 20 CSNK2A1(4), ELK1(3), FOS(2), GRB2(2), HRAS(3), IGF1(10), IGF1R(14), IRS1(5), JUN(1), MAP2K1(14), MAPK3(4), MAPK8(1), PIK3CA(10), PIK3R1(2), PTPN11(10), RAF1(10), RASA1(4), SHC1(2), SOS1(10), SRF(3) 10120687 114 77 101 51 55 18 3 28 9 1 0.600 1.000 1.000 362 KREBS_TCA_CYCLE ACO2, CGI_48, CS, DLAT, DLD, DLST, DLST, DLSTP, FH, IDH2, IDH3A, IDH3B, IDH3G, KIAA1348, MDH1, MDH2, OGDH, PC, PDHA1, PDHA2, PDHB, PDHX, PDK1, PDK2, PDK3, PDK4, PDP2, PPM2C, SDHA, SDHA, SDHAL2, SDHB, SDHC, SDHD, SUCLA2, SUCLG1, SUCLG2, WDR50 30 ACO2(5), CS(2), DLAT(4), DLD(3), FH(3), IDH2(1), IDH3A(3), IDH3B(2), IDH3G(2), MDH1(3), MDH2(3), OGDH(8), PC(14), PDHA1(4), PDHA2(20), PDHB(1), PDHX(2), PDK1(2), PDK2(4), PDK3(5), PDK4(7), PDP2(6), SDHA(3), SDHC(3), SDHD(1), SUCLG1(3), SUCLG2(2) 11617075 116 77 113 56 74 6 7 12 17 0 0.272 1.000 1.000 363 NFKBPATHWAY Inactive nuclear factor kB (NF-kB) is inhibited by the IkB family in the cytoplasm; active NF-kB is localized in the nucleus and regulates transcription of a variety of genes. CHUK, FADD, IKBKB, IKBKG, IL1A, IL1R1, IRAK1, MAP3K1, MAP3K14, MAP3K7, MAP3K7IP1, MYD88, NFKB1, NFKBIA, RELA, RIPK1, TLR4, TNF, TNFAIP3, TNFRSF1A, TNFRSF1B, TRADD, TRAF6 21 CHUK(2), IKBKB(4), IL1A(5), IL1R1(13), IRAK1(5), MAP3K1(4), MAP3K14(6), MAP3K7(1), MYD88(3), NFKB1(6), NFKBIA(2), RELA(4), RIPK1(3), TLR4(41), TNF(1), TNFAIP3(2), TNFRSF1A(4), TNFRSF1B(4), TRAF6(4) 9802459 114 77 108 63 80 8 5 10 11 0 0.555 1.000 1.000 364 ACE_INHIBITOR_PATHWAY_PHARMGKB ACE, AGT, AGTR1, AGTR2, BDKRB2, KNG1, NOS3, REN 8 ACE(37), AGT(8), AGTR1(10), AGTR2(9), BDKRB2(9), KNG1(14), NOS3(19), REN(11) 4044623 117 76 111 71 76 8 7 8 18 0 0.157 1.000 1.000 365 CALCINEURINPATHWAY Increased intracellular calcium activates the phosphatase calcineurin in differentiating keratinocytes. CALM1, CALM2, CALM3, CDKN1A, GNAQ, MARCKS, NFATC1, NFATC2, NFATC3, NFATC4, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, SP1, SP3, SYT1 18 CALM1(1), CALM2(1), CDKN1A(3), GNAQ(6), MARCKS(1), NFATC1(16), NFATC2(11), NFATC3(10), NFATC4(17), PLCG1(8), PPP3CA(5), PPP3CB(3), PPP3CC(2), PRKCA(8), SP1(5), SP3(1), SYT1(23) 8553269 121 76 114 52 77 13 8 8 15 0 0.171 1.000 1.000 366 EICOSANOID_SYNTHESIS ALOX12, ALOX15, ALOX15B, ALOX5, ALOX5AP, DPEP1, GGT1, IPLA2(GAMMA), LTA4H, LTC4S, PLA2G2A, PLA2G6, PTGDS, PTGES, PTGIS, PTGS1, PTGS2, TBXAS1 17 ALOX12(6), ALOX15(10), ALOX15B(8), ALOX5(12), ALOX5AP(1), DPEP1(4), GGT1(8), LTA4H(5), PLA2G2A(2), PLA2G6(12), PTGDS(3), PTGES(1), PTGIS(17), PTGS1(20), PTGS2(13), TBXAS1(16) 6093078 138 76 134 74 90 12 4 14 18 0 0.0338 1.000 1.000 367 GCRPATHWAY Corticosteroids activate the glucocorticoid receptor (GR), which inhibits NF-kB and activates Annexin-1, thus inhibiting the inflammatory response. ADRB2, AKT1, ANXA1, CALM1, CALM2, CALM3, CRN, GNAS, GNB1, GNGT1, HSPCA, NFKB1, NOS3, NPPA, NR3C1, PIK3CA, PIK3R1, RELA, SYT1 17 ADRB2(3), AKT1(4), ANXA1(7), CALM1(1), CALM2(1), GNAS(25), GNB1(1), NFKB1(6), NOS3(19), NPPA(4), NR3C1(7), PIK3CA(10), PIK3R1(2), RELA(4), SYT1(23) 7274907 117 76 109 61 78 11 5 18 4 1 0.675 1.000 1.000 368 HSA00290_VALINE_LEUCINE_AND_ISOLEUCINE_BIOSYNTHESIS Genes involved in valine, leucine and isoleucine biosynthesis BCAT1, BCAT2, IARS, IARS2, ILVBL, LARS, LARS2, PDHA1, PDHA2, PDHB, VARS, VARS2 12 BCAT1(13), BCAT2(1), IARS(8), IARS2(16), ILVBL(5), LARS(12), LARS2(5), PDHA1(4), PDHA2(20), PDHB(1), VARS(18), VARS2(7) 7701338 110 76 102 47 70 12 3 13 12 0 0.196 1.000 1.000 369 IL3PATHWAY IL-3 promotes proliferation and differentiation of hematopoietic cells via a heterodimeric receptor that activates the Stat5 and MAP kinase pathways. CSF2RB, FOS, GRB2, HRAS, IL3, IL3RA, JAK2, MAP2K1, MAPK3, PTPN6, RAF1, SHC1, SOS1, STAT5A, STAT5B 15 CSF2RB(24), FOS(2), GRB2(2), HRAS(3), IL3(3), IL3RA(7), JAK2(8), MAP2K1(14), MAPK3(4), PTPN6(5), RAF1(10), SHC1(2), SOS1(10), STAT5A(3), STAT5B(6) 7176496 103 76 95 45 58 5 6 17 17 0 0.230 1.000 1.000 370 METHANE_METABOLISM ADH5, ATP6V0C, SHMT1, CAT, EPX, LPO, MPO, PRDX1, PRDX2, PRDX5, PRDX6, SHMT1, SHMT2, TPO 13 ADH5(3), CAT(8), EPX(9), LPO(20), MPO(11), PRDX1(3), PRDX2(3), PRDX6(4), SHMT1(2), SHMT2(3), TPO(47) 4829739 113 76 109 62 84 10 1 8 10 0 0.102 1.000 1.000 371 MTORPATHWAY Mammalian target of rapamycin (mTOR) senses mitogenic factors and nutrients, including ATP, and induces cell proliferation. AKT1, EIF3S10, EIF4A1, EIF4A2, EIF4B, EIF4E, EIF4EBP1, EIF4G1, EIF4G2, EIF4G3, FKBP1A, FRAP1, MKNK1, PDK2, PDPK1, PIK3CA, PIK3R1, PPP2CA, PTEN, RPS6, RPS6KB1, TSC1, TSC2 20 AKT1(4), EIF4A1(4), EIF4A2(4), EIF4B(5), EIF4EBP1(1), EIF4G1(18), EIF4G2(4), EIF4G3(17), MKNK1(6), PDK2(4), PDPK1(3), PIK3CA(10), PIK3R1(2), RPS6(1), RPS6KB1(3), TSC1(9), TSC2(12) 10973561 107 76 104 43 60 11 6 11 17 2 0.189 1.000 1.000 372 N_GLYCAN_DEGRADATION AGA, FLJ21865, FUCA1, FUCA2, GLB1, HEXA, HEXB, LCT, MAN2C1, MANBA, NEU1, NEU2, NEU3, NEU4 13 AGA(4), FUCA1(3), GLB1(9), HEXA(6), HEXB(4), LCT(51), MAN2C1(7), MANBA(8), NEU1(6), NEU2(17), NEU3(4), NEU4(16) 6724874 135 76 132 59 100 10 1 13 11 0 0.0692 1.000 1.000 373 SMALL_LIGAND_GPCRS C9orf47, CNR1, CNR2, DNMT1, EDG1, EDG2, EDG5, EDG6, MTNR1A, MTNR1B, PTAFR, PTGDR, PTGER1, PTGER2, PTGER4, PTGFR, PTGIR, TBXA2R 13 C9orf47(3), CNR1(13), CNR2(5), DNMT1(20), MTNR1A(10), MTNR1B(8), PTAFR(2), PTGDR(11), PTGER2(7), PTGER4(2), PTGFR(21), PTGIR(5), TBXA2R(4) 4554060 111 76 106 85 76 14 4 9 8 0 0.397 1.000 1.000 374 HSA04140_REGULATION_OF_AUTOPHAGY Genes involved in regulation of autophagy ATG12, ATG3, ATG5, ATG7, BECN1, GABARAP, GABARAPL1, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNG, INS, LOC441925, PIK3C3, PIK3R4, PRKAA1, PRKAA2, ULK1, ULK2, ULK3 29 ATG12(2), ATG5(2), ATG7(11), BECN1(3), IFNA1(1), IFNA10(2), IFNA13(1), IFNA14(8), IFNA16(11), IFNA17(2), IFNA2(1), IFNA21(7), IFNA4(1), IFNA5(4), IFNA6(2), IFNA7(6), IFNA8(3), IFNG(4), PIK3C3(3), PIK3R4(6), PRKAA1(1), PRKAA2(30), ULK1(9), ULK2(7), ULK3(1) 8523717 128 75 122 66 89 8 6 13 12 0 0.314 1.000 1.000 375 IL6PATHWAY IL-6 binding to its receptor activates JAK kinases and a variety of transcription factors, with effects in neuronal differentiation, bone loss, and inflammation. CEBPB, CSNK2A1, ELK1, FOS, GRB2, HRAS, IL6, IL6R, IL6ST, JAK1, JAK2, JAK3, JUN, MAP2K1, MAPK3, PTPN11, RAF1, SHC1, SOS1, SRF, STAT3 21 CSNK2A1(4), ELK1(3), FOS(2), GRB2(2), HRAS(3), IL6(2), IL6R(3), IL6ST(10), JAK1(6), JAK2(8), JAK3(11), JUN(1), MAP2K1(14), MAPK3(4), PTPN11(10), RAF1(10), SHC1(2), SOS1(10), SRF(3), STAT3(9) 9715583 117 75 108 57 54 16 5 31 11 0 0.726 1.000 1.000 376 MEF2DPATHWAY Mef2 transcription factors promote calcium-induced apoptosis in T cells and are regulated by MAP kinases and histone deacetylases. CABIN1, CALM1, CALM2, CALM3, CAPN2, CAPNS1, CAPNS2, EP300, HDAC1, HDAC2, MEF2D, NFATC1, NFATC2, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, SYT1, TRA@, TRB@ 18 CABIN1(16), CALM1(1), CALM2(1), CAPN2(5), CAPNS1(3), CAPNS2(1), EP300(18), HDAC1(2), HDAC2(2), MEF2D(6), NFATC1(16), NFATC2(11), PPP3CA(5), PPP3CB(3), PPP3CC(2), PRKCA(8), SYT1(23) 10021019 123 75 117 51 78 7 10 12 16 0 0.117 1.000 1.000 377 PLCPATHWAY Phospholipase C hydrolyzes the membrane lipid PIP2 to DAG, which activates protein kinase C, and IP3, which causes calcium influx. AKT1, PIK3CA, PIK3R1, PLCB1, PLCG1, PRKCA, PRKCB1, VAV1 7 AKT1(4), PIK3CA(10), PIK3R1(2), PLCB1(54), PLCG1(8), PRKCA(8), VAV1(19) 5255521 105 74 97 55 79 4 2 8 11 1 0.429 1.000 1.000 378 TCYTOTOXICPATHWAY Cytotoxic T cells release perforin and granzyme to lyse foreign cell targets and express Fas ligand to promote Fas-induced apoptosis. CD2, CD28, CD3D, CD3E, CD3G, CD3Z, CD8A, ICAM1, ITGAL, ITGB2, PTPRC, THY1, TRA@, TRB@ 11 CD2(27), CD28(2), CD3D(7), CD3E(2), CD3G(1), CD8A(2), ICAM1(2), ITGAL(28), ITGB2(16), PTPRC(35), THY1(1) 4349294 123 74 114 49 83 7 4 8 21 0 0.00382 1.000 1.000 379 THELPERPATHWAY Helper T cells coordinate the actions of B cells, macrophages, and other immune cells via surface molecules such as T cell receptor/CD3 and their characteristic marker CD4. CD2, CD28, CD3D, CD3E, CD3G, CD3Z, CD4, ICAM1, ITGAL, ITGB2, PTPRC, THY1, TRA@, TRB@ 11 CD2(27), CD28(2), CD3D(7), CD3E(2), CD3G(1), CD4(8), ICAM1(2), ITGAL(28), ITGB2(16), PTPRC(35), THY1(1) 4559302 129 74 119 53 86 8 4 9 22 0 0.00447 1.000 1.000 380 C21_STEROID_HORMONE_METABOLISM AKR1C4, AKR1D1, CYP11A1, CYP11B1, CYP11B2, CYP17A1, CYP21A2, HSD11B1, HSD11B2, HSD3B1, HSD3B2 10 AKR1C4(10), AKR1D1(19), CYP11A1(14), CYP11B1(18), CYP11B2(14), CYP17A1(7), CYP21A2(13), HSD11B2(3), HSD3B1(14), HSD3B2(14) 3704364 126 73 116 68 86 13 5 8 14 0 0.0165 1.000 1.000 381 FRUCTOSE_AND_MANNOSE_METABOLISM AKR1B1, ALDOA, ALDOB, ALDOC, FBP1, FBP2, FPGT, GCK, GMDS, GMPPA, GMPPB, HK1, HK2, HK3, KHK, MPI, PFKFB1, PFKFB3, PFKFB4, PFKM, PFKP, PMM1, PMM2, SORD, TPI1 25 AKR1B1(2), ALDOA(2), ALDOB(14), ALDOC(4), FBP1(3), FBP2(2), GCK(17), GMDS(5), GMPPA(1), GMPPB(4), HK1(3), HK2(13), HK3(14), KHK(1), MPI(1), PFKFB1(4), PFKFB3(2), PFKFB4(6), PFKM(2), PFKP(2), PMM1(3), PMM2(2), SORD(2), TPI1(1) 9718967 110 73 105 78 75 14 5 4 12 0 0.499 1.000 1.000 382 HSA00140_C21_STEROID_HORMONE_METABOLISM Genes involved in C21-steroid hormone metabolism AKR1C4, AKR1D1, CYP11A1, CYP11B1, CYP11B2, CYP17A1, CYP21A2, HSD11B1, HSD11B2, HSD3B1, HSD3B2 10 AKR1C4(10), AKR1D1(19), CYP11A1(14), CYP11B1(18), CYP11B2(14), CYP17A1(7), CYP21A2(13), HSD11B2(3), HSD3B1(14), HSD3B2(14) 3704364 126 73 116 68 86 13 5 8 14 0 0.0165 1.000 1.000 383 HSA00232_CAFFEINE_METABOLISM Genes involved in caffeine metabolism CYP1A2, CYP2A13, CYP2A6, CYP2A7, NAT1, NAT2, XDH 7 CYP1A2(8), CYP2A13(12), CYP2A6(9), CYP2A7(10), NAT1(2), NAT2(10), XDH(59) 3283317 110 73 102 70 86 6 6 2 10 0 0.0893 1.000 1.000 384 HSA00271_METHIONINE_METABOLISM Genes involved in methionine metabolism AHCY, AMD1, BHMT, CBS, CTH, DNMT1, DNMT3A, DNMT3B, KIAA0828, MARS, MARS2, MAT1A, MAT2B, MTAP, MTFMT, MTR, SRM, TAT 17 AHCY(5), BHMT(8), CBS(7), CTH(1), DNMT1(20), DNMT3A(8), DNMT3B(13), MARS(7), MARS2(4), MAT1A(6), MAT2B(1), MTAP(4), MTFMT(2), MTR(11), SRM(1), TAT(19) 8554047 117 73 115 46 75 8 8 11 15 0 0.0169 1.000 1.000 385 HSA00563_GLYCOSYLPHOSPHATIDYLINOSITOL_ANCHOR_BIOSYNTHESIS Genes involved in glycosylphosphatidylinositol(GPI)-anchor biosynthesis GPAA1, GPLD1, PGAP1, PIGA, PIGB, PIGC, PIGF, PIGG, PIGH, PIGK, PIGL, PIGM, PIGN, PIGO, PIGP, PIGQ, PIGS, PIGT, PIGU, PIGV, PIGW, PIGX, PIGZ 23 GPAA1(2), GPLD1(22), PGAP1(8), PIGA(1), PIGB(3), PIGC(2), PIGF(2), PIGG(9), PIGH(2), PIGK(7), PIGL(3), PIGM(1), PIGN(3), PIGO(12), PIGQ(9), PIGS(1), PIGT(1), PIGU(7), PIGV(8), PIGW(1), PIGX(2), PIGZ(3) 9743789 109 73 108 49 61 8 7 23 10 0 0.122 1.000 1.000 386 HSA00902_MONOTERPENOID_BIOSYNTHESIS Genes involved in monoterpenoid biosynthesis CYP2C19, CYP2C9 2 CYP2C19(75), CYP2C9(38) 826261 113 73 100 73 87 6 2 2 16 0 0.644 1.000 1.000 387 SA_MMP_CYTOKINE_CONNECTION Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix. ACE, CD44, CSF1, FCGR3A, IL1B, IL6R, SELL, SPN, TGFB1, TGFB2, TNF, TNFRSF1A, TNFRSF1B, TNFRSF8, TNFSF8 15 ACE(37), CD44(5), CSF1(12), FCGR3A(7), IL1B(8), IL6R(3), SELL(10), SPN(5), TGFB1(2), TGFB2(3), TNF(1), TNFRSF1A(4), TNFRSF1B(4), TNFRSF8(19), TNFSF8(3) 5291585 123 73 117 58 89 7 7 3 17 0 0.0440 1.000 1.000 388 UCALPAINPATHWAY Calpains promote formation of integrin adhesion clusters which recruit Rac to enable the formation of mature focal adhesions that do not contain calpain. ACTA1, ACTN1, ACTN2, ACTN3, ARHA, CAPN1, CAPNS1, CAPNS2, ITGA1, ITGB1, ITGB3, PTK2, PXN, RAC1, SPTAN1, SRC, TLN1, VIL2 15 ACTA1(4), ACTN1(8), ACTN2(20), ACTN3(3), CAPN1(4), CAPNS1(3), CAPNS2(1), ITGA1(24), ITGB1(4), ITGB3(15), PTK2(7), PXN(2), SPTAN1(10), SRC(2), TLN1(12) 11330944 119 73 117 66 76 9 5 13 15 1 0.158 1.000 1.000 389 CELL2CELLPATHWAY Epithelial cell adhesion proteins such as cadherins transduce signals into the cell via catenins, which alter cell shape and motility. ACTN1, ACTN2, ACTN3, BCAR1, CSK, CTNNA1, CTNNA2, CTNNB1, PECAM1, PTK2, PXN, SRC, VCL 13 ACTN1(8), ACTN2(20), ACTN3(3), BCAR1(5), CSK(1), CTNNA1(3), CTNNA2(30), CTNNB1(14), PTK2(7), PXN(2), SRC(2), VCL(8) 7709352 103 72 98 55 60 8 7 12 15 1 0.233 1.000 1.000 390 HSA00680_METHANE_METABOLISM Genes involved in methane metabolism ADH5, CAT, EPX, LPO, MPO, MTHFR, PRDX6, SHMT1, SHMT2, TPO 10 ADH5(3), CAT(8), EPX(9), LPO(20), MPO(11), MTHFR(3), PRDX6(4), SHMT1(2), SHMT2(3), TPO(47) 4769022 110 72 106 64 84 9 1 8 8 0 0.174 1.000 1.000 391 RARRXRPATHWAY RXR and RAR suppress transcription in the absence of ligand and, on binding trans- or 9-cis-retinoic acid, are ubiquitinated to allow transcription to proceed. ERCC3, GTF2A1, GTF2B, GTF2E1, GTF2F1, HDAC3, NCOA1, NCOA2, NCOA3, NCOR2, PCAF, POLR2A, RARA, RXRA, TBP 14 ERCC3(6), GTF2A1(2), GTF2B(4), GTF2E1(3), GTF2F1(5), HDAC3(5), NCOA1(9), NCOA2(13), NCOA3(18), NCOR2(26), POLR2A(13), RARA(4), RXRA(4), TBP(4) 10139266 116 72 114 47 89 4 5 10 8 0 0.0741 1.000 1.000 392 SA_TRKA_RECEPTOR The TrkA receptor binds nerve growth factor to activate MAP kinase pathways and promote cell growth. AKT1, AKT2, AKT3, ARHA, CDKN1A, ELK1, GRB2, HRAS, MAP2K1, MAP2K2, NGFB, NGFR, NTRK1, PIK3CA, PIK3CD, SHC1, SOS1 15 AKT1(4), AKT2(8), AKT3(3), CDKN1A(3), ELK1(3), GRB2(2), HRAS(3), MAP2K1(14), MAP2K2(5), NGFR(8), NTRK1(16), PIK3CA(10), PIK3CD(8), SHC1(2), SOS1(10) 6528195 99 72 90 38 48 16 4 19 12 0 0.112 1.000 1.000 393 STATIN_PATHWAY_PHARMGKB ABCA1, APOA1, APOA1, LOC440837, APOA4, APOC1, APOC2, APOC3, APOC3, LOC440838, APOE, CETP, CYP7A1, DGAT1, HMGCR, LCAT, LDLR, LIPC, LPL, LRP1, SCARB1, SOAT1 18 ABCA1(15), APOA1(2), APOA4(9), APOC1(3), APOC3(2), APOE(1), CETP(6), CYP7A1(8), DGAT1(1), HMGCR(12), LDLR(17), LIPC(10), LPL(6), LRP1(40), SCARB1(5), SOAT1(3) 11287509 140 72 133 70 73 20 8 18 20 1 0.124 1.000 1.000 394 AMINOACYL_TRNA_BIOSYNTHESIS AARS, CARS, DARS, EPRS, FARS2, FARSLB, GARS, HARS, HARSL, IARS, KARS, LARS, LARS2, MARS, MARS2, NARS, QARS, RARS, SARS, TARS, WARS, WARS2, YARS 21 AARS(5), CARS(8), DARS(4), EPRS(13), FARS2(6), GARS(6), HARS(6), IARS(8), KARS(3), LARS(12), LARS2(5), MARS(7), MARS2(4), NARS(2), QARS(6), RARS(7), SARS(5), TARS(5), WARS(5), WARS2(4), YARS(3) 13156197 124 71 119 52 75 11 6 13 18 1 0.119 1.000 1.000 395 CARBON_FIXATION ALDOA, ALDOB, ALDOC, FBP1, FBP2, GOT1, GOT2, GPT, GPT2, MDH1, MDH2, ME1, ME2, ME3, PGK1, PKLR, PKM2, RPE, RPE, LOC440001, RPIA, TKT, TPI1 21 ALDOA(2), ALDOB(14), ALDOC(4), FBP1(3), FBP2(2), GOT1(6), GOT2(6), GPT(3), GPT2(2), MDH1(3), MDH2(3), ME1(20), ME2(2), ME3(8), PGK1(2), PKLR(13), PKM2(7), TKT(6), TPI1(1) 7391778 107 71 104 59 78 9 3 6 10 1 0.129 1.000 1.000 396 HCMVPATHWAY Cytomegalovirus activates MAP kinase pathways in the host cell, inducing transcription of viral genes. AKT1, CREB1, MAP2K1, MAP2K2, MAP2K3, MAP2K6, MAP3K1, MAPK1, MAPK14, MAPK3, NFKB1, PIK3CA, PIK3R1, RB1, RELA, SP1 16 AKT1(4), MAP2K1(14), MAP2K2(5), MAP2K3(8), MAP2K6(3), MAP3K1(4), MAPK1(4), MAPK14(5), MAPK3(4), NFKB1(6), PIK3CA(10), PIK3R1(2), RB1(10), RELA(4), SP1(5) 7896373 88 71 79 40 39 12 4 15 15 3 0.578 1.000 1.000 397 HSA00450_SELENOAMINO_ACID_METABOLISM Genes involved in selenoamino acid metabolism AHCY, CARM1, CBS, CTH, GGT1, GGTL3, GGTL4, HEMK1, KIAA0828, LCMT1, LCMT2, MARS, MARS2, MAT1A, MAT2B, METTL2B, METTL6, PAPSS1, PAPSS2, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, SCLY, SEPHS1, SEPHS2, WBSCR22 26 AHCY(5), CARM1(4), CBS(7), CTH(1), GGT1(8), HEMK1(4), LCMT1(4), LCMT2(1), MARS(7), MARS2(4), MAT1A(6), MAT2B(1), METTL2B(7), METTL6(1), PAPSS1(4), PAPSS2(5), PRMT2(2), PRMT3(5), PRMT5(7), PRMT7(3), PRMT8(11), SCLY(4), SEPHS1(2), SEPHS2(2), WBSCR22(1) 10230283 106 71 105 50 65 13 6 10 12 0 0.118 1.000 1.000 398 NITROGEN_METABOLISM AMT, ASNS, CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA8, CA9, CPS1, CTH, GLS, GLS2, GLUD1, GLUL, HAL 21 AMT(1), ASNS(8), CA1(9), CA12(3), CA2(12), CA3(6), CA4(3), CA5A(3), CA5B(1), CA6(4), CA7(2), CA8(6), CA9(8), CPS1(26), CTH(1), GLS(2), GLS2(3), GLUD1(2), GLUL(2), HAL(14) 7703057 116 71 112 59 82 6 3 14 11 0 0.378 1.000 1.000 399 PENTOSE_PHOSPHATE_PATHWAY ALDOA, ALDOB, ALDOC, FBP1, FBP2, G6PD, GPI, H6PD, PFKM, PFKP, PGD, PGLS, PGM1, PGM3, PRPS1, PRPS1L1, PRPS2, RBKS, RPE, RPE, LOC440001, RPIA, TAL1, TALDO1, TALDO1, HSUP1, TKT 23 ALDOA(2), ALDOB(14), ALDOC(4), FBP1(3), FBP2(2), G6PD(3), GPI(3), H6PD(7), PFKM(2), PFKP(2), PGD(9), PGLS(2), PGM1(6), PGM3(1), PRPS1(2), PRPS1L1(13), PRPS2(2), RBKS(4), TAL1(9), TALDO1(3), TKT(6) 8339251 99 71 95 66 66 7 6 8 12 0 0.524 1.000 1.000 400 SA_DIACYLGLYCEROL_SIGNALING DAG (diacylglycerol) signaling activity ESR1, ESR2, ITPKA, PDE1A, PDE1B, PLCB1, PLCB2, PRL, TRH, VIP 9 ESR1(6), ESR2(9), PDE1B(16), PLCB1(54), PLCB2(12), PRL(3), TRH(4), VIP(5) 4021726 109 71 101 50 83 3 2 9 12 0 0.0328 1.000 1.000 401 ERBB4PATHWAY ErbB4 (aka HER4) is a receptor tyrosine kinase that binds neuregulins as well as members of the EGF family, which also target EGF receptors. ADAM17, ERBB4, NRG2, NRG3, PRKCA, PRKCB1, PSEN1 6 ADAM17(1), ERBB4(54), NRG2(7), NRG3(24), PRKCA(8), PSEN1(1) 3645885 95 70 85 35 70 4 3 4 14 0 0.0323 1.000 1.000 402 FLUMAZENILPATHWAY Flumazenil is a benzodiazepine receptor antagonist that may induce protective preconditioning in ischemic cardiomyocytes. GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GPX1, PRKCE, SOD1 9 GABRA1(18), GABRA2(18), GABRA3(22), GABRA4(15), GABRA5(4), GABRA6(28), GPX1(3), PRKCE(6) 3162923 114 70 99 54 83 8 3 10 8 2 0.116 1.000 1.000 403 GLUTATHIONE_METABOLISM ANPEP, G6PD, GCLC, GCLM, GGT1, GPX1, GPX2, GPX3, GPX4, GPX5, GSS, GSTA1, GSTA2, GSTA3, GSTA4, GSTM1, GSTM2, GSTM3, GSTM4, GSTM5, GSTO2, GSTP1, GSTT1, GSTT2, GSTZ1, IDH1, IDH2, MGST1, MGST2, MGST3, PGD 29 ANPEP(24), G6PD(3), GCLC(5), GCLM(2), GGT1(8), GPX1(3), GPX3(4), GPX5(17), GSS(8), GSTA1(6), GSTA2(3), GSTA3(1), GSTA4(1), GSTM1(2), GSTM3(4), GSTM4(2), GSTM5(6), GSTO2(1), GSTP1(3), GSTT1(1), GSTZ1(1), IDH2(1), MGST1(2), MGST2(2), MGST3(1), PGD(9) 7021651 120 70 114 57 79 8 7 16 10 0 0.0258 1.000 1.000 404 HSA00604_GLYCOSPHINGOLIPID_BIOSYNTHESIS_GANGLIOSERIES Genes involved in glycosphingolipid biosynthesis - ganglioseries B3GALT4, B4GALNT1, GLB1, HEXA, HEXB, LCT, SLC33A1, ST3GAL1, ST3GAL2, ST3GAL5, ST6GALNAC3, ST6GALNAC4, ST6GALNAC5, ST6GALNAC6, ST8SIA1, ST8SIA5 16 B3GALT4(2), B4GALNT1(5), GLB1(9), HEXA(6), HEXB(4), LCT(51), SLC33A1(6), ST3GAL1(7), ST3GAL2(1), ST3GAL5(2), ST6GALNAC3(6), ST6GALNAC4(4), ST6GALNAC5(10), ST6GALNAC6(1), ST8SIA1(1), ST8SIA5(10) 6733408 125 70 123 71 87 10 1 17 10 0 0.386 1.000 1.000 405 HSA00760_NICOTINATE_AND_NICOTINAMIDE_METABOLISM Genes involved in nicotinate and nicotinamide metabolism AOX1, BST1, C9orf95, CD38, ENPP1, ENPP3, NADK, NADSYN1, NMNAT1, NMNAT2, NMNAT3, NNMT, NNT, NP, NT5C, NT5C1A, NT5C1B, NT5C2, NT5C3, NT5E, NT5M, NUDT12, PBEF1, QPRT 22 AOX1(26), BST1(2), CD38(6), ENPP1(13), ENPP3(13), NADK(4), NADSYN1(4), NMNAT1(1), NMNAT2(5), NMNAT3(11), NNMT(10), NNT(3), NT5C1A(6), NT5C2(3), NT5C3(2), NT5E(6), NT5M(2), NUDT12(5), QPRT(6) 8796033 128 70 121 61 77 11 5 16 19 0 0.302 1.000 1.000 406 LEPTINPATHWAY Leptin is a peptide secreted by adipose tissue that, in skeletal muscle, promotes fatty acid oxidation, decreases cells' lipid content, and promotes insulin sensitivity. ACACA, CPT1A, LEP, LEPR, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKAG1, PRKAG2 10 ACACA(20), CPT1A(14), LEP(4), LEPR(29), PRKAA1(1), PRKAA2(30), PRKAB1(2), PRKAB2(2), PRKAG1(3), PRKAG2(8) 5959068 113 70 105 53 78 5 3 9 18 0 0.405 1.000 1.000 407 NDKDYNAMINPATHWAY Endocytotic role of NDK, Phosphins and Dynamin AMPH, AP2A1, AP2M1, BIN1, CALM1, CALM2, CALM3, DNM1, EPN1, EPS15, NME1, NME2, PICALM, PPP3CA, PPP3CB, PPP3CC, SYNJ1, SYNJ2, SYT1 19 AMPH(19), AP2A1(2), AP2M1(2), BIN1(5), CALM1(1), CALM2(1), DNM1(9), EPN1(6), EPS15(3), PICALM(2), PPP3CA(5), PPP3CB(3), PPP3CC(2), SYNJ1(20), SYNJ2(22), SYT1(23) 8733714 125 70 119 60 85 9 4 14 13 0 0.296 1.000 1.000 408 NEUTROPHILPATHWAY Neutrophils are phagocytotic leukocytes that destroy foreign cells with reactive oxygen species or enzymatic digestion and express CD11 and CD18. CD44, ICAM1, ITGAL, ITGAM, ITGB2, PECAM1, SELE, SELL 8 CD44(5), ICAM1(2), ITGAL(28), ITGAM(23), ITGB2(16), SELE(33), SELL(10) 4195201 117 70 117 46 85 4 4 6 18 0 0.00523 1.000 1.000 409 NO2IL12PATHWAY Macrophages activate NK cells by releasing IL-12, which induces NK cytotoxic activity in coordination with NO produced by inducible nitric oxide synthase II. CCR5, CD2, CD3D, CD3E, CD3G, CD3Z, CD4, CXCR3, IFNG, IL12A, IL12B, IL12RB1, IL12RB2, JAK2, NOS2A, STAT4, TYK2 15 CCR5(10), CD2(27), CD3D(7), CD3E(2), CD3G(1), CD4(8), CXCR3(4), IFNG(4), IL12A(4), IL12B(3), IL12RB1(15), IL12RB2(3), JAK2(8), STAT4(26), TYK2(8) 5942242 130 70 121 58 86 11 4 11 18 0 0.0588 1.000 1.000 410 PARKINPATHWAY In Parkinson's disease, dopaminergic neurons contain Lewy bodies consisting of alpha-synuclein and parkin, an E3 ubiquitin ligase that targets glycosylated alpha-synuclein. GPR37, PARK2, PNUTL1, SNCA, SNCAIP, UBE2E2, UBE2F, UBE2G1, UBE2G2, UBE2L3, UBE2L6, UBL1 10 GPR37(9), PARK2(10), SNCA(2), SNCAIP(62), UBE2E2(4), UBE2F(4), UBE2G2(1), UBE2L3(1), UBE2L6(1) 2633195 94 69 85 33 72 9 3 5 5 0 0.0182 1.000 1.000 411 CTLA4PATHWAY T cell activation requires interaction with an antigen-MHC-I complex on an antigen-presenting cell (APC), as well as CD28 interaction with the APC's CD80 or 86. CD28, CD3D, CD3E, CD3G, CD3Z, CD80, CD86, CTLA4, GRB2, HLA-DRA, HLA-DRB1, ICOS, ICOSL, IL2, ITK, LCK, PIK3CA, PIK3R1, PTPN11, TRA@, TRB@ 17 CD28(2), CD3D(7), CD3E(2), CD3G(1), CD80(4), CD86(25), CTLA4(2), GRB2(2), HLA-DRA(12), ICOS(2), IL2(4), ITK(24), LCK(15), PIK3CA(10), PIK3R1(2), PTPN11(10) 5224691 124 68 115 44 82 8 2 15 16 1 0.0638 1.000 1.000 412 TH1TH2PATHWAY Helper T subtype Th1 produces pro-inflammatory cytokines that stimulate phagocytosis, while Th2 cells promote antibody production and activate eosinophils. CD28, CD86, HLA-DRA, HLA-DRB1, IFNG, IFNGR1, IFNGR2, IL12A, IL12B, IL12RB1, IL12RB2, IL18, IL18R1, IL2, IL2RA, IL4, IL4R, TNFRSF5, TNFSF5 17 CD28(2), CD86(25), HLA-DRA(12), IFNG(4), IFNGR1(3), IFNGR2(4), IL12A(4), IL12B(3), IL12RB1(15), IL12RB2(3), IL18(3), IL18R1(21), IL2(4), IL2RA(5), IL4(1), IL4R(16) 5160516 125 68 117 47 92 6 0 8 19 0 0.0103 1.000 1.000 413 ATMPATHWAY The tumor-suppressing protein kinase ATM responds to radiation-induced DNA damage by blocking cell-cycle progression and activating DNA repair. ABL1, ATM, BRCA1, CDKN1A, CHEK1, CHEK2, GADD45A, JUN, MAPK8, MDM2, MRE11A, NBS1, NFKB1, NFKBIA, RAD50, RAD51, RBBP8, RELA, TP53, TP73 18 ABL1(13), ATM(15), BRCA1(15), CDKN1A(3), CHEK1(2), CHEK2(2), JUN(1), MAPK8(1), MDM2(1), MRE11A(6), NFKB1(6), NFKBIA(2), RAD50(6), RBBP8(4), RELA(4), TP73(6) 11779980 87 67 86 45 44 11 3 15 14 0 0.913 1.000 1.000 414 EPOPATHWAY Erythropoietin, which activates the MAPK pathway, stimulates erythrocyte production and is an effective treatment for anemia. CSNK2A1, ELK1, EPO, EPOR, FOS, GRB2, HRAS, JAK2, JUN, MAP2K1, MAPK3, MAPK8, PLCG1, PTPN6, RAF1, SHC1, SOS1, STAT5A, STAT5B 19 CSNK2A1(4), ELK1(3), EPO(5), EPOR(1), FOS(2), GRB2(2), HRAS(3), JAK2(8), JUN(1), MAP2K1(14), MAPK3(4), MAPK8(1), PLCG1(8), PTPN6(5), RAF1(10), SHC1(2), SOS1(10), STAT5A(3), STAT5B(6) 8709330 92 67 85 47 44 7 7 22 12 0 0.696 1.000 1.000 415 CARM1PATHWAY The methyltransferase CARM1 interacts with transcription factors such as CBP/p300 and methylates histones H3 and H4. CARM1, CREB1, CREBBP, EP300, NCOA3, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RARA, RXRA 13 CARM1(4), CREBBP(24), EP300(18), NCOA3(18), PRKACB(4), PRKACG(11), PRKAR1A(3), PRKAR1B(4), PRKAR2A(1), PRKAR2B(5), RARA(4), RXRA(4) 8464461 100 66 100 51 60 9 5 14 12 0 0.722 1.000 1.000 416 CREMPATHWAY The transcription factor CREM activates a post-meiotic transcriptional cascade culminating in spermatogenesis. ADCY1, CREM, FHL5, FSHB, FSHR, GNAS, XPO1 7 ADCY1(34), FHL5(13), FSHB(8), FSHR(19), GNAS(25), XPO1(3) 3879407 102 66 97 56 66 11 6 9 10 0 0.640 1.000 1.000 417 LONGEVITYPATHWAY Caloric restriction in animals often increases lifespan, which may occur via decreased IGF receptor expression and consequent expression of stress-resistance proteins. AKT1, CAT, FOXO3A, GH1, GHR, HRAS, IGF1, IGF1R, PIK3CA, PIK3R1, SHC1, SOD1, SOD2, SOD3 13 AKT1(4), CAT(8), GH1(3), GHR(40), HRAS(3), IGF1(10), IGF1R(14), PIK3CA(10), PIK3R1(2), SHC1(2) 5427098 96 66 88 41 69 10 1 10 5 1 0.151 1.000 1.000 418 RACCYCDPATHWAY Ras, Rac, and Rho coordinate to induce cyclin D1 expression and activate cdk2 to promote the G1/S transition. AKT1, ARHA, CCND1, CCNE1, CDK2, CDK4, CDK6, CDKN1A, CDKN1B, E2F1, HRAS, MAPK1, MAPK3, NFKB1, NFKBIA, PAK1, PIK3CA, PIK3R1, RAC1, RAF1, RB1, RELA, TFDP1 21 AKT1(4), CCND1(2), CCNE1(4), CDK4(7), CDK6(2), CDKN1A(3), CDKN1B(1), E2F1(5), HRAS(3), MAPK1(4), MAPK3(4), NFKB1(6), NFKBIA(2), PAK1(4), PIK3CA(10), PIK3R1(2), RAF1(10), RB1(10), RELA(4), TFDP1(2) 8054180 89 66 85 44 37 10 7 18 14 3 0.620 1.000 1.000 419 RASPATHWAY Ras activation stimulates many signaling cascades, including PI3K/AKT activation to inhibit apoptosis. AKT1, ARHA, BAD, BCL2L1, CASP9, CDC42, CHUK, ELK1, H2AFX, HRAS, MAP2K1, MAPK3, MLLT7, NFKB1, PIK3CA, PIK3R1, RAC1, RAF1, RALA, RALBP1, RALGDS, RELA, RHOA 20 AKT1(4), CASP9(2), CDC42(2), CHUK(2), ELK1(3), H2AFX(2), HRAS(3), MAP2K1(14), MAPK3(4), NFKB1(6), PIK3CA(10), PIK3R1(2), RAF1(10), RALA(1), RALBP1(3), RALGDS(12), RELA(4), RHOA(2) 7544887 86 66 78 45 45 13 2 19 6 1 0.685 1.000 1.000 420 HSA00272_CYSTEINE_METABOLISM Genes involved in cysteine metabolism CARS, CARS2, CDO1, CTH, GOT1, GOT2, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, MPST, SDS, SULT1B1, SULT1C2, SULT1C4, SULT4A1 17 CARS(8), CARS2(3), CDO1(6), CTH(1), GOT1(6), GOT2(6), LDHA(4), LDHAL6A(4), LDHAL6B(6), LDHB(2), LDHC(5), MPST(2), SDS(2), SULT1B1(10), SULT1C2(6), SULT1C4(15), SULT4A1(10) 5134550 96 65 93 31 66 5 11 4 10 0 0.00266 1.000 1.000 421 FREEPATHWAY Neutrophils release superoxide to induce lysis in invading bacteria; in neighboring endothelial cells, superoxide dismutase scavenges radicals but produces pro-apoptotic peroxides. GPX1, GSR, GSS, IL8, NFKB1, NOX1, RELA, SOD1, TNF, XDH 10 GPX1(3), GSR(2), GSS(8), IL8(1), NFKB1(6), NOX1(13), RELA(4), TNF(1), XDH(59) 4027688 97 64 93 47 72 8 4 7 6 0 0.0701 1.000 1.000 422 N_GLYCAN_BIOSYNTHESIS ALG3, ALG5, B4GALT1, B4GALT2, B4GALT3, B4GALT5, DDOST, DPAGT1, DPM1, FUT8, GCS1, MAN1A1, MAN1B1, MGAT1, MGAT2, MGAT3, MGAT4A, MGAT4B, MGAT5, RPN1, RPN2, ST6GAL1 21 ALG3(4), ALG5(3), B4GALT1(2), B4GALT2(2), B4GALT3(2), B4GALT5(2), DDOST(2), DPAGT1(2), DPM1(1), FUT8(8), MAN1A1(18), MAN1B1(3), MGAT1(3), MGAT2(2), MGAT3(11), MGAT4A(8), MGAT4B(1), MGAT5(6), RPN2(4), ST6GAL1(6) 8166824 90 64 88 57 56 10 3 11 10 0 0.689 1.000 1.000 423 NGFPATHWAY Nerve growth factor (NGF) stimulates neural survival and proliferation via the TrkA and p75 receptors, which induce DAG and IP3 production and activate Ras. CSNK2A1, DPM2, ELK1, FOS, GRB2, HRAS, JUN, KLK2, MAP2K1, MAPK3, MAPK8, NGFB, NGFR, PIK3CA, PIK3R1, PLCG1, RAF1, SHC1, SOS1 18 CSNK2A1(4), DPM2(1), ELK1(3), FOS(2), GRB2(2), HRAS(3), JUN(1), KLK2(5), MAP2K1(14), MAPK3(4), MAPK8(1), NGFR(8), PIK3CA(10), PIK3R1(2), PLCG1(8), RAF1(10), SHC1(2), SOS1(10) 7776410 90 64 82 45 44 10 3 23 9 1 0.757 1.000 1.000 424 PTDINSPATHWAY Phosphoinositide 3 kinase (PI3K) phosphorylate inositol rings of phosphoinositide lipids, influencing vesicle trafficking, cell proliferation, and migration. AKT1, AP2A1, AP2M1, ARF1, BAD, BTK, EEA1, GRASP, GSK3A, GSK3B, LYN, PDPK1, PFKL, PFKM, PFKP, PFKX, PLCG1, PRKCE, PRKCZ, RAB5A, RAC1, RPS6KB1, VAV2 21 AKT1(4), AP2A1(2), AP2M1(2), BTK(16), EEA1(3), GRASP(2), GSK3A(1), GSK3B(3), LYN(10), PDPK1(3), PFKL(4), PFKM(2), PFKP(2), PLCG1(8), PRKCE(6), PRKCZ(7), RAB5A(2), RPS6KB1(3), VAV2(3) 9923604 83 64 82 55 47 9 6 5 16 0 0.651 1.000 1.000 425 STRESSPATHWAY Tumor necrosis factor receptor TNFR1 promotes apoptosis and activates the pro-inflammatory NF-kB, while TNFR2 activates stress-activated protein kinases (SAPKs). ATF1, CASP2, CHUK, CRADD, IKBKB, IKBKG, JUN, LTA, MAP2K3, MAP2K4, MAP2K6, MAP3K1, MAP3K14, MAP4K2, MAPK14, MAPK8, NFKB1, NFKBIA, RELA, RIPK1, TANK, TNF, TNFRSF1A, TRADD, TRAF2 24 ATF1(4), CASP2(1), CHUK(2), CRADD(2), IKBKB(4), JUN(1), LTA(4), MAP2K3(8), MAP2K4(4), MAP2K6(3), MAP3K1(4), MAP3K14(6), MAP4K2(7), MAPK14(5), MAPK8(1), NFKB1(6), NFKBIA(2), RELA(4), RIPK1(3), TNF(1), TNFRSF1A(4), TRAF2(2) 9713625 78 64 78 47 45 12 3 9 9 0 0.731 1.000 1.000 426 ACHPATHWAY Nicotinic acetylcholine receptors are ligand-gated ion channels that primarily mediate neuromuscular signaling and may inhibit neuronal apoptosis via the AKT pathway. AKT1, BAD, CHRNB1, CHRNG, FOXO3A, MUSK, PIK3CA, PIK3R1, PTK2, PTK2B, RAPSN, SRC, TERT, TNFSF6, YWHAH 13 AKT1(4), CHRNB1(3), CHRNG(3), MUSK(33), PIK3CA(10), PIK3R1(2), PTK2(7), PTK2B(10), RAPSN(1), SRC(2), TERT(9) 6644116 84 63 80 73 56 7 0 12 8 1 0.987 1.000 1.000 427 IGF1RPATHWAY Insulin-like growth factor receptor IGF-1R promotes cell growth and inhibits apoptosis on binding of ligands IGF-1 and 2 via Ras activation and the AKT pathway. AKT1, BAD, GRB2, HRAS, IGF1R, IRS1, MAP2K1, MAPK1, MAPK3, PIK3CA, PIK3R1, RAF1, SHC1, SOS1, YWHAH 15 AKT1(4), GRB2(2), HRAS(3), IGF1R(14), IRS1(5), MAP2K1(14), MAPK1(4), MAPK3(4), PIK3CA(10), PIK3R1(2), RAF1(10), SHC1(2), SOS1(10) 7774509 84 63 74 35 44 10 3 18 8 1 0.352 1.000 1.000 428 PPARGPATHWAY PPAR-gamma is a nuclear hormone receptor that is activated by fatty acids and regulates transcription through co-activations like Src-1 and Tif2. CREBBP, EP300, LPL, NCOA1, NCOA2, PPARBP, PPARG, PPARGC1, RXRA 7 CREBBP(24), EP300(18), LPL(6), NCOA1(9), NCOA2(13), PPARG(14), RXRA(4) 7598223 88 63 85 33 51 11 4 13 9 0 0.250 1.000 1.000 429 CERAMIDEPATHWAY Ceramide is a lipid signaling molecule that can activate proliferative or apoptotic pathways, depending on signaling context, localization, and cell type. BAD, BAX, BCL2, CASP8, CYCS, FADD, MAP2K1, MAP2K4, MAP3K1, MAPK1, MAPK3, MAPK8, NFKB1, NSMAF, PDCD8, RAF1, RELA, RIPK1, SMPD1, TNFRSF1A, TRADD, TRAF2 21 BAX(3), BCL2(2), CASP8(9), CYCS(1), MAP2K1(14), MAP2K4(4), MAP3K1(4), MAPK1(4), MAPK3(4), MAPK8(1), NFKB1(6), NSMAF(6), RAF1(10), RELA(4), RIPK1(3), SMPD1(2), TNFRSF1A(4), TRAF2(2) 8326760 83 62 76 35 45 7 4 15 12 0 0.309 1.000 1.000 430 HSA03010_RIBOSOME Genes involved in ribosome C15orf15, FAU, hCG_1644323, hCG_1984468, hCG_2041321, hCG_21078, hCG_26523, LOC283412, LOC284064, LOC284230, LOC284288, LOC284393, LOC285053, LOC342994, LOC347292, LOC388720, LOC389342, LOC390876, LOC391656, LOC400652, LOC402057, LOC439992, LOC440055, LOC440589, LOC440733, LOC440737, LOC441377, LOC441876, LOC441907, MRPL13, MRPS7, RPL10A, RPL10L, RPL11, RPL12, RPL13, RPL13A, RPL14, RPL18, RPL18A, RPL19, RPL21, RPL22L1, RPL23A, RPL23AP2, RPL24, RPL26, RPL27, RPL27A, RPL28, RPL29, RPL3, RPL30, RPL31, RPL32, RPL34, RPL35, RPL35A, RPL36A, RPL36AL, RPL37, RPL37A, RPL38, RPL39, RPL3L, RPL41, RPL6, RPL7, RPL8, RPL9, RPS10, RPS11, RPS12, RPS13, RPS15A, RPS16, RPS18, RPS2, RPS20, RPS21, RPS23, RPS24, RPS25, RPS26, RPS26P10, RPS27, RPS28, RPS29, RPS3, RPS3A, RPS4Y1, RPS5, RPS6, RPS7, RPS8, RPS9, RPSA, tcag7.23 66 MRPL13(2), MRPS7(1), RPL10A(1), RPL10L(8), RPL11(4), RPL12(1), RPL13(1), RPL13A(2), RPL14(1), RPL18(5), RPL18A(2), RPL19(1), RPL21(1), RPL26(1), RPL27(3), RPL27A(1), RPL29(1), RPL3(2), RPL30(1), RPL32(1), RPL35(1), RPL35A(1), RPL38(1), RPL39(1), RPL3L(5), RPL6(1), RPL7(1), RPS11(1), RPS13(1), RPS16(2), RPS18(2), RPS2(2), RPS20(2), RPS24(1), RPS26(1), RPS29(1), RPS3A(1), RPS5(1), RPS6(1), RPS7(4), RPS8(1), RPSA(10) 9137773 82 62 81 49 44 6 7 13 12 0 0.619 1.000 1.000 431 METHIONINE_METABOLISM AHCY, BHMT, CBS, CTH, DNMT1, DNMT2, DNMT3A, DNMT3B, MARS, MARS2, MAT1A, MAT2B, MTR 12 AHCY(5), BHMT(8), CBS(7), CTH(1), DNMT1(20), DNMT3A(8), DNMT3B(13), MARS(7), MARS2(4), MAT1A(6), MAT2B(1), MTR(11) 7198538 91 62 90 32 57 6 7 9 12 0 0.00869 1.000 1.000 432 CACAMPATHWAY Calcium functions as a second messenger activating the calcium/calmodulin-dependent kinases, which phosphorylate targets such as CREB. CALM1, CALM2, CALM3, CAMK1, CAMK1G, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CAMKK1, CAMKK2, CREB1, SYT1 14 CALM1(1), CALM2(1), CAMK1(5), CAMK1G(11), CAMK2A(6), CAMK2B(6), CAMK2D(6), CAMK2G(5), CAMK4(17), CAMKK1(3), CAMKK2(9), SYT1(23) 4737123 93 61 87 65 66 8 3 8 8 0 0.746 1.000 1.000 433 CASPASEPATHWAY Caspases are cysteine proteases active in apoptosis; caspase-8 and 9 cleave and activate other caspases, while 3, 6, and 7 cleave cellular targets. ADPRT, APAF1, ARHGDIB, BIRC2, BIRC3, BIRC4, CASP1, CASP10, CASP2, CASP3, CASP4, CASP6, CASP7, CASP8, CASP9, CYCS, DFFA, DFFB, GZMB, LMNA, LMNB1, LMNB2, PRF1 21 APAF1(6), ARHGDIB(4), BIRC2(6), BIRC3(7), CASP1(10), CASP10(6), CASP2(1), CASP3(2), CASP4(2), CASP7(4), CASP8(9), CASP9(2), CYCS(1), DFFA(2), DFFB(2), GZMB(3), LMNA(7), LMNB1(1), LMNB2(4), PRF1(11) 7977529 90 61 89 44 52 10 6 12 10 0 0.510 1.000 1.000 434 HSA00061_FATTY_ACID_BIOSYNTHESIS Genes involved in fatty acid biosynthesis ACACA, ACACB, FASN, MCAT, OLAH, OXSM 6 ACACA(20), ACACB(23), FASN(23), MCAT(2), OLAH(11), OXSM(2) 6461545 81 61 79 46 49 8 3 8 13 0 0.382 1.000 1.000 435 HSA03020_RNA_POLYMERASE Genes involved in RNA polymerase POLR1A, POLR1B, POLR1C, POLR1D, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLR3A, POLR3B, POLR3G, POLR3GL, POLR3H, POLR3K, ZNRD1 23 POLR1A(13), POLR1B(9), POLR1C(1), POLR2A(13), POLR2B(12), POLR2C(1), POLR2D(1), POLR2E(3), POLR2F(1), POLR2H(2), POLR2J(1), POLR3A(7), POLR3B(14), POLR3G(1), POLR3GL(2), POLR3H(1), POLR3K(1) 9595670 83 61 81 42 51 8 6 11 7 0 0.464 1.000 1.000 436 IGF1MTORPATHWAY Growth factor IGF-1 activates AKT, Gsk3-beta, and mTOR to promote muscle hypertrophy. AKT1, EIF2B5, EIF2S1, EIF2S2, EIF2S3, EIF4E, EIF4EBP1, FRAP1, GSK3B, IGF1, IGF1R, INPPL1, PDK2, PDPK1, PIK3CA, PIK3R1, PPP2CA, PTEN, RPS6, RPS6KB1 18 AKT1(4), EIF2B5(2), EIF2S1(1), EIF2S3(1), EIF4EBP1(1), GSK3B(3), IGF1(10), IGF1R(14), INPPL1(16), PDK2(4), PDPK1(3), PIK3CA(10), PIK3R1(2), RPS6(1), RPS6KB1(3) 7695833 75 61 70 40 46 11 5 6 6 1 0.623 1.000 1.000 437 INFLAMPATHWAY Interleukins and TNF serve as signals to coordinate the inflammatory response, in which macrophages recruit and activate neutrophils, fibroblasts, and T cells. CD4, CSF1, CSF2, CSF3, HLA-DRA, HLA-DRB1, IFNA1, IFNB1, IFNG, IL10, IL11, IL12A, IL12B, IL13, IL15, IL1A, IL2, IL3, IL4, IL5, IL6, IL7, IL8, LTA, PDGFA, TGFB1, TGFB2, TGFB3, TNF 29 CD4(8), CSF1(12), CSF2(2), CSF3(4), HLA-DRA(12), IFNA1(1), IFNB1(6), IFNG(4), IL10(3), IL11(3), IL12A(4), IL12B(3), IL13(2), IL15(3), IL1A(5), IL2(4), IL3(3), IL4(1), IL5(4), IL6(2), IL7(4), IL8(1), LTA(4), PDGFA(1), TGFB1(2), TGFB2(3), TGFB3(3), TNF(1) 5372273 105 61 101 52 70 6 3 8 18 0 0.0138 1.000 1.000 438 P53HYPOXIAPATHWAY Hypoxia induces p53 accumulation and consequent apoptosis with p53-mediated cell cycle arrest, which is present under conditions of DNA damage. ABCB1, AKT1, ATM, BAX, CDKN1A, CPB2, CSNK1A1, CSNK1D, FHL2, GADD45A, HIC1, HIF1A, HSPA1A, HSPCA, IGFBP3, MAPK8, MDM2, NFKBIB, NQO1, TP53 18 ABCB1(39), AKT1(4), ATM(15), BAX(3), CDKN1A(3), CPB2(1), CSNK1A1(3), CSNK1D(3), HIC1(1), HIF1A(4), IGFBP3(2), MAPK8(1), MDM2(1), NFKBIB(1), NQO1(2) 8149165 83 61 74 40 51 7 3 10 12 0 0.570 1.000 1.000 439 TCRAPATHWAY The kinases Lck and Fyn phosphorylate and activate the T cell receptor, which recognizes antigen-bound MHCII and leads to T cell activation. CD3D, CD3E, CD3G, CD3Z, CD4, FYN, HLA-DRA, HLA-DRB1, LCK, PTPRC, TRA@, TRB@, ZAP70 10 CD3D(7), CD3E(2), CD3G(1), CD4(8), FYN(7), HLA-DRA(12), LCK(15), PTPRC(35), ZAP70(7) 3618890 94 61 88 35 62 8 3 7 14 0 0.0169 1.000 1.000 440 TIDPATHWAY On ligand binding, interferon gamma receptors stimulate JAK2 kinase to phosphorylate STAT transcription factors, which promote expression of interferon responsive genes. DNAJA3, HSPA1A, IFNG, IFNGR1, IFNGR2, IKBKB, JAK2, LIN7A, NFKB1, NFKBIA, RB1, RELA, TIP-1, TNF, TNFRSF1A, TNFRSF1B, TP53, USH1C, WT1 16 DNAJA3(5), IFNG(4), IFNGR1(3), IFNGR2(4), IKBKB(4), JAK2(8), NFKB1(6), NFKBIA(2), RB1(10), RELA(4), TNF(1), TNFRSF1A(4), TNFRSF1B(4), USH1C(22), WT1(8) 6855529 89 61 84 35 39 8 4 13 23 2 0.169 1.000 1.000 441 41BBPATHWAY TNF-type receptor 4-1BB is bound by TRAF1 to activate the MAP kinase pathway in activated T cells. ATF2, CHUK, IFNG, IKBKB, IL2, IL4, JUN, MAP3K1, MAP3K5, MAP4K5, MAPK14, MAPK8, NFKB1, NFKBIA, RELA, TNFRSF9, TNFSF9, TRAF2 18 ATF2(6), CHUK(2), IFNG(4), IKBKB(4), IL2(4), IL4(1), JUN(1), MAP3K1(4), MAP3K5(23), MAP4K5(4), MAPK14(5), MAPK8(1), NFKB1(6), NFKBIA(2), RELA(4), TNFRSF9(4), TNFSF9(4), TRAF2(2) 7809108 81 60 75 40 43 6 2 13 17 0 0.568 1.000 1.000 442 CELLCYCLEPATHWAY Cyclins interact with cyclin-dependent kinases to form active kinase complexes that regulate progression through the cell cycle. CCNA1, CCNB1, CCND1, CCND2, CCND3, CCNE1, CCNH, CDC2, CDC25A, CDK2, CDK4, CDK6, CDK7, CDKN1A, CDKN1B, CDKN2A, CDKN2B, CDKN2C, CDKN2D, E2F1, RB1, RBL1, TFDP1 21 CCNA1(14), CCND1(2), CCND2(6), CCND3(2), CCNE1(4), CCNH(2), CDC25A(8), CDK4(7), CDK6(2), CDK7(2), CDKN1A(3), CDKN1B(1), CDKN2C(1), E2F1(5), RB1(10), RBL1(12), TFDP1(2) 6344980 83 60 80 28 44 5 7 14 11 2 0.0379 1.000 1.000 443 CHEMICALPATHWAY DNA damage promotes Bid cleavage, which stimulates mitochondrial cytochrome c release and consequent caspase activation, resulting in apoptosis. ADPRT, AKT1, APAF1, ATM, BAD, BAX, BCL2, BCL2L1, BID, CASP3, CASP6, CASP7, CASP9, CYCS, EIF2S1, PRKCA, PRKCB1, PTK2, PXN, STAT1, TLN1, TP53 19 AKT1(4), APAF1(6), ATM(15), BAX(3), BCL2(2), CASP3(2), CASP7(4), CASP9(2), CYCS(1), EIF2S1(1), PRKCA(8), PTK2(7), PXN(2), STAT1(5), TLN1(12) 10803756 74 60 71 37 40 10 3 10 11 0 0.559 1.000 1.000 444 CITRATE_CYCLE_TCA_CYCLE ACO1, ACO2, CS, DLD, DLST, DLSTP, FH, IDH1, IDH2, IDH3A, IDH3B, IDH3G, MDH1, MDH2, PC, PCK1, SDHA, SDHA, SDHAL2, SDHB, SUCLA2, SUCLG1, SUCLG2 19 ACO1(6), ACO2(5), CS(2), DLD(3), FH(3), IDH2(1), IDH3A(3), IDH3B(2), IDH3G(2), MDH1(3), MDH2(3), PC(14), PCK1(25), SDHA(3), SUCLG1(3), SUCLG2(2) 8118366 80 60 78 54 55 1 5 9 10 0 0.825 1.000 1.000 445 HIFPATHWAY Under normal conditions, hypoxia inducible factor HIF-1 is degraded; under hypoxic conditions, it activates transcription of genes controlled by hpoxic response elements (HREs). ARNT, ASPH, COPS5, CREB1, EDN1, EP300, EPO, HIF1A, HSPCA, JUN, LDHA, NOS3, P4HB, VEGF, VHL 13 ARNT(9), ASPH(5), COPS5(4), EDN1(9), EP300(18), EPO(5), HIF1A(4), JUN(1), LDHA(4), NOS3(19), P4HB(4), VHL(4) 6986537 86 60 83 37 52 5 6 12 11 0 0.424 1.000 1.000 446 NICOTINATE_AND_NICOTINAMIDE_METABOLISM AOX1, CD38, ENPP1, ENPP3, NADSYN1, NMNAT1, NMNAT2, NNMT, NNT, NP, NT5C, NT5E, NT5M, QPRT 13 AOX1(26), CD38(6), ENPP1(13), ENPP3(13), NADSYN1(4), NMNAT1(1), NMNAT2(5), NNMT(10), NNT(3), NT5E(6), NT5M(2), QPRT(6) 5951098 95 60 89 45 58 8 4 11 14 0 0.321 1.000 1.000 447 PS1PATHWAY Presenilin is required for gamma-secretase activity to activate Notch signaling; presenilin also inhibits beta-catenin in the Wnt/Frizzled pathway. ADAM17, APC, AXIN1, BTRC, CTNNB1, DLL1, DVL1, FZD1, GSK3B, NOTCH1, PSEN1, RBPSUH, TCF1, WNT1 12 ADAM17(1), APC(25), AXIN1(9), BTRC(4), CTNNB1(14), DLL1(2), FZD1(5), GSK3B(3), NOTCH1(9), PSEN1(1), WNT1(2) 8630441 75 60 74 49 35 9 6 11 14 0 0.968 1.000 1.000 448 SA_PTEN_PATHWAY PTEN is a tumor suppressor that dephosphorylates the lipid messenger phosphatidylinositol triphosphate. AKT1, AKT2, AKT3, BPNT1, GRB2, ILK, MAPK1, MAPK3, PDK1, PIK3CA, PIK3CD, PIP3-E, PTEN, PTK2B, RBL2, SHC1, SOS1 15 AKT1(4), AKT2(8), AKT3(3), GRB2(2), ILK(2), MAPK1(4), MAPK3(4), PDK1(2), PIK3CA(10), PIK3CD(8), PTK2B(10), RBL2(6), SHC1(2), SOS1(10) 8058859 75 60 74 41 39 8 3 18 7 0 0.806 1.000 1.000 449 TUBBYPATHWAY Tubby is activated by phospholipase C activity and hydrolysis of PIP2, after which it enters the nucleus and regulates transcription. CHRM1, GNAQ, GNB1, GNGT1, HTR2C, PLCB1, TUB 7 CHRM1(5), GNAQ(6), GNB1(1), HTR2C(13), PLCB1(54), TUB(10) 2920046 89 60 81 43 68 2 2 8 9 0 0.130 1.000 1.000 450 AKAPCENTROSOMEPATHWAY Protein Kinase A at the Centrosome AKAP9, ARHA, CDC2, MAP2, PCNT1, PCNT2, PPP1CA, PPP2CA, PRKACB, PRKACG, PRKAG1, PRKAR2A, PRKAR2B, PRKCE, PRKCL1 10 AKAP9(34), MAP2(19), PPP1CA(1), PRKACB(4), PRKACG(11), PRKAG1(3), PRKAR2A(1), PRKAR2B(5), PRKCE(6) 7395267 84 59 84 43 47 8 5 10 13 1 0.780 1.000 1.000 451 FEEDERPATHWAY Sugars such as mannose, galactose, and fructose are enzymatically converted to glucose via feeder pathways that lead to glycolysis. HK1, KHK, LCT, MPI, PGM1, PYGL, PYGM, TPI1, TREH 9 HK1(3), KHK(1), LCT(51), MPI(1), PGM1(6), PYGL(9), PYGM(12), TPI1(1), TREH(4) 5390737 88 59 87 65 66 6 2 7 7 0 0.647 1.000 1.000 452 GPCRDB_CLASS_A_RHODOPSIN_LIKE2 CYSLTR1, CYSLTR2, GPR109B, GPR161, GPR171, GPR18, GPR34, GPR39, GPR41, GPR42, GPR45, GPR65, GPR68, GPR75, GPR81, LYPDC1 13 CYSLTR1(5), CYSLTR2(4), GPR161(8), GPR171(10), GPR18(4), GPR34(3), GPR39(12), GPR45(7), GPR65(14), GPR68(3), GPR75(5) 3996039 75 59 72 38 52 5 3 7 8 0 0.00779 1.000 1.000 453 SA_CASPASE_CASCADE Apoptosis is mediated by caspases, cysteine proteases arranged in a proteolytic cascade. ADPRT, APAF1, BIRC2, BIRC3, BIRC4, CASP10, CASP3, CASP7, CASP8, CASP9, DFFA, DFFB, GZMB, PRF1, SCAP, SREBF1, SREBF2, TNFRSF6, TNFSF6 15 APAF1(6), BIRC2(6), BIRC3(7), CASP10(6), CASP3(2), CASP7(4), CASP8(9), CASP9(2), DFFA(2), DFFB(2), GZMB(3), PRF1(11), SCAP(10), SREBF1(5), SREBF2(10) 7431718 85 59 82 47 49 8 6 12 10 0 0.637 1.000 1.000 454 UREA_CYCLE_AND_METABOLISM_OF_AMINO_GROUPS ACY1, ALDH18A1, ARG1, ARG2, ASL, ASS, CKB, CKM, CKMT1, CKMT1B, CKMT1A, CKMT2, CPS1, GAMT, GATM, GLUD1, NAGS, OAT, ODC1, OTC, PYCR1, SMS 20 ACY1(2), ALDH18A1(7), ARG1(2), ARG2(2), ASL(6), CKM(3), CKMT1A(1), CKMT2(5), CPS1(26), GAMT(4), GATM(6), GLUD1(2), NAGS(1), OAT(4), ODC1(3), OTC(4), PYCR1(1), SMS(4) 7061223 83 59 80 34 49 9 4 10 11 0 0.0771 1.000 1.000 455 GLYCOSAMINOGLYCAN_DEGRADATION ARSB, GALNS, GLB1, GNS, GUSB, HEXA, HEXB, IDS, IDUA, LCT, NAGLU 11 ARSB(2), GALNS(5), GLB1(9), GNS(1), GUSB(5), HEXA(6), HEXB(4), IDS(9), IDUA(4), LCT(51), NAGLU(4) 5844316 100 58 98 51 77 6 0 8 9 0 0.237 1.000 1.000 456 HSA00532_CHONDROITIN_SULFATE_BIOSYNTHESIS Genes involved in chondroitin sulfate biosynthesis B3GALT6, B3GAT1, B3GAT2, B3GAT3, B4GALT7, ChGn, CHPF, CHST11, CHST12, CHST13, CHST14, CHST3, CHST7, CHSY-2, CHSY1, CSGlcA-T, DSE, GALNAC4S-6ST, GALNACT-2, UST, XYLT1, XYLT2 16 B3GAT1(8), B3GAT2(2), B3GAT3(4), CHPF(4), CHST11(7), CHST12(5), CHST13(3), CHST14(3), CHST3(2), CHST7(3), CHSY1(8), DSE(18), XYLT1(12), XYLT2(4) 5550512 83 58 83 57 52 11 4 8 8 0 0.562 1.000 1.000 457 HSA00592_ALPHA_LINOLENIC_ACID_METABOLISM Genes involved in alpha-Linolenic acid metabolism ACOX1, ACOX3, FADS2, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6 15 ACOX1(8), ACOX3(13), FADS2(4), PLA2G12B(4), PLA2G1B(1), PLA2G2A(2), PLA2G2D(5), PLA2G2E(5), PLA2G2F(6), PLA2G3(17), PLA2G4A(15), PLA2G5(2), PLA2G6(12) 4137149 94 58 94 39 64 6 2 5 16 1 0.0139 1.000 1.000 458 HSA00740_RIBOFLAVIN_METABOLISM Genes involved in riboflavin metabolism ACP1, ACP2, ACP5, ACP6, ACPP, ACPT, ENPP1, ENPP3, FLAD1, LHPP, MTMR1, MTMR2, MTMR6, PHPT1, RFK, TYR 16 ACP1(4), ACP2(2), ACP5(3), ACP6(12), ACPP(9), ACPT(3), ENPP1(13), ENPP3(13), FLAD1(10), LHPP(1), MTMR1(5), MTMR2(2), MTMR6(2), TYR(9) 6127315 88 58 84 27 59 5 5 4 15 0 0.0168 1.000 1.000 459 ST_STAT3_PATHWAY The transcription factor STAT3 is involved in cell growth regulation and is commonly upregulated in tumors. CISH, IL6, IL6R, JAK1, JAK2, JAK3, PIAS3, PTPRU, REG1A, SRC, STAT3 11 CISH(4), IL6(2), IL6R(3), JAK1(6), JAK2(8), JAK3(11), PIAS3(6), PTPRU(21), REG1A(7), SRC(2), STAT3(9) 6201273 79 58 78 47 47 8 3 9 12 0 0.568 1.000 1.000 460 ST_TUMOR_NECROSIS_FACTOR_PATHWAY Tumor necrosis factor is a pro-inflammatory cytokine that activates NF-kB and c-Jun. BAG4, BIRC2, BIRC3, CASP3, CASP8, CFLAR, FADD, HRB, IKBKG, JUN, MAP2K4, MAP3K3, MAP3K7, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, NR2C2, RALBP1, RIPK1, TNF, TNFAIP3, TNFRSF1A, TNFRSF1B, TRADD, TRAF2 27 BAG4(3), BIRC2(6), BIRC3(7), CASP3(2), CASP8(9), CFLAR(4), JUN(1), MAP2K4(4), MAP3K3(8), MAP3K7(1), NFKB1(6), NFKB2(3), NFKBIA(2), NFKBIB(1), NFKBIL1(3), NR2C2(1), RALBP1(3), RIPK1(3), TNF(1), TNFAIP3(2), TNFRSF1A(4), TNFRSF1B(4), TRAF2(2) 11048054 80 58 79 49 44 5 8 13 10 0 0.876 1.000 1.000 461 ARAPPATHWAY ADP-ribosylation factors (ARFs), members of the Ras superfamily, regulate eukaryotic vesicular trafficking and activate phospholipase D's. ARF1, ARFGAP1, ARFGAP3, ARFGEF2, BIG1, CENTD1, CENTD2, CLTA, CLTB, COP, COPA, DDEF1, DDEF2, GBF1, GPLD1, KDELR1, KDELR2, KDELR3, PSCD1, PSCD2, PSCD3, PSCD4 12 ARFGAP1(5), ARFGAP3(3), ARFGEF2(15), CLTA(1), CLTB(1), COPA(10), GBF1(14), GPLD1(22), KDELR1(1), KDELR3(2) 6692144 74 57 73 41 38 6 3 16 11 0 0.653 1.000 1.000 462 DNA_POLYMERASE POLA, POLB, POLD1, POLD2, POLE, POLG, POLL, POLQ, POLS 7 POLB(1), POLD1(7), POLD2(2), POLE(16), POLG(9), POLL(8), POLQ(25) 6834067 68 57 67 34 38 7 2 13 8 0 0.375 1.000 1.000 463 PMLPATHWAY Ring-shaped PML nuclear bodies regulate transcription and are required co-activators in p53- and DAXX-mediated apoptosis. CREBBP, DAXX, HRAS, PAX3, PML, PRAM-1, RARA, RB1, SIRT1, SP100, TNF, TNFRSF1A, TNFRSF1B, TNFRSF6, TNFSF6, TP53, UBL1 12 CREBBP(24), DAXX(9), HRAS(3), PAX3(3), PML(3), RARA(4), RB1(10), SIRT1(2), SP100(11), TNF(1), TNFRSF1A(4), TNFRSF1B(4) 7352895 78 57 78 29 31 11 7 12 15 2 0.159 1.000 1.000 464 RBPATHWAY The ATM protein kinase recognizes DNA damage and blocks cell cycle progression by phosphorylating chk1 and p53, which normally inhibits Rb to allow G1/S transitions. ATM, CDC2, CDC25A, CDC25B, CDC25C, CDK2, CDK4, CHEK1, MYT1, RB1, TP53, WEE1, YWHAH 11 ATM(15), CDC25A(8), CDC25B(4), CDC25C(5), CDK4(7), CHEK1(2), MYT1(21), RB1(10), WEE1(2) 6841535 74 57 69 27 41 5 3 11 12 2 0.196 1.000 1.000 465 AKTPATHWAY Second messenger PIP3 promotes cell survival by activating the anti-apoptotic kinase AKT. AKT1, BAD, CASP9, CHUK, FOXO1A, FOXO3A, GH1, GHR, HSPCA, MLLT7, NFKB1, NFKBIA, PDPK1, PIK3CA, PIK3R1, PPP2CA, RELA, TNFSF6, YWHAH 14 AKT1(4), CASP9(2), CHUK(2), GH1(3), GHR(40), NFKB1(6), NFKBIA(2), PDPK1(3), PIK3CA(10), PIK3R1(2), RELA(4) 5713096 78 56 72 41 56 7 2 7 5 1 0.636 1.000 1.000 466 CCR5PATHWAY CCR5 is a G-protein coupled receptor expressed in macrophages that recognizes chemokine ligands and is targeted by the HIV envelope protein GP120. CALM1, CALM2, CALM3, CCL2, CCL4, CCR5, CXCL12, CXCR4, FOS, GNAQ, JUN, MAPK14, MAPK8, PLCG1, PRKCA, PRKCB1, PTK2B, SYT1 17 CALM1(1), CALM2(1), CCL2(2), CCR5(10), CXCL12(3), CXCR4(3), FOS(2), GNAQ(6), JUN(1), MAPK14(5), MAPK8(1), PLCG1(8), PRKCA(8), PTK2B(10), SYT1(23) 5650078 84 56 78 65 55 7 5 11 6 0 0.927 1.000 1.000 467 STEROID_BIOSYNTHESIS CYP17A1, F13B, HSD17B1, HSD17B2, HSD17B3, HSD17B4, HSD17B7, HSD3B1, HSD3B2 9 CYP17A1(7), F13B(32), HSD17B2(12), HSD17B3(5), HSD17B4(6), HSD17B7(1), HSD3B1(14), HSD3B2(14) 3272351 91 56 85 37 67 6 5 2 11 0 0.0279 1.000 1.000 468 ERK5PATHWAY Signaling between a tissue and its innervating axon stimulates retrograde transport via Trk receptors, which activate Erk5, which induces transcription of anti-apoptotic factors. AKT1, CREB1, GRB2, HRAS, MAPK1, MAPK3, MAPK7, MEF2A, MEF2B, MEF2C, MEF2D, NTRK1, PIK3CA, PIK3R1, PLCG1, RPS6KA1, SHC1 17 AKT1(4), GRB2(2), HRAS(3), MAPK1(4), MAPK3(4), MAPK7(4), MEF2A(3), MEF2B(2), MEF2C(4), MEF2D(6), NTRK1(16), PIK3CA(10), PIK3R1(2), PLCG1(8), RPS6KA1(8), SHC1(2) 7721182 82 55 79 61 48 12 5 9 7 1 0.970 1.000 1.000 469 HSA00626_NAPHTHALENE_AND_ANTHRACENE_DEGRADATION Genes involved in naphthalene and anthracene degradation CARM1, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, HEMK1, LCMT1, LCMT2, METTL2B, METTL6, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, WBSCR22 18 CARM1(4), DHRS1(3), DHRS2(8), DHRS3(4), DHRS7(1), DHRSX(6), HEMK1(4), LCMT1(4), LCMT2(1), METTL2B(7), METTL6(1), PRMT2(2), PRMT3(5), PRMT5(7), PRMT7(3), PRMT8(11), WBSCR22(1) 6155382 72 55 71 38 43 11 2 10 6 0 0.379 1.000 1.000 470 HSA01040_POLYUNSATURATED_FATTY_ACID_BIOSYNTHESIS Genes involved in polyunsaturated fatty acid biosynthesis ACAA1, ACOX1, ACOX3, ELOVL2, ELOVL5, ELOVL6, FADS1, FADS2, FASN, GPSN2, HADHA, HSD17B12, PECR, SCD 13 ACAA1(6), ACOX1(8), ACOX3(13), ELOVL2(2), ELOVL5(1), ELOVL6(2), FADS2(4), FASN(23), HADHA(6), HSD17B12(3), PECR(1), SCD(3) 5843588 72 55 72 30 45 6 4 8 9 0 0.0175 1.000 1.000 471 IL22BPPATHWAY IL-22 is produced by T cells and induces the acute phase inflammatory response in hepatocytes. IL10RA, IL22, IL22RA1, IL22RA2, JAK1, JAK2, JAK3, SOCS3, STAT1, STAT3, STAT5A, STAT5B, TYK2 13 IL10RA(9), IL22(2), IL22RA1(12), IL22RA2(3), JAK1(6), JAK2(8), JAK3(11), SOCS3(1), STAT1(5), STAT3(9), STAT5A(3), STAT5B(6), TYK2(8) 7442404 83 55 83 49 48 8 6 15 6 0 0.643 1.000 1.000 472 MITOCHONDRIAL_FATTY_ACID_BETAOXIDATION ACADL, ACADM, ACADS, ACADVL, ACSL1, ACSL3, ACSL4, CPT1A, CPT2, DCI, EHHADH, HADHA, HADHSC, MGC5139, PECR, SCP2, SLC25A20 15 ACADL(5), ACADM(4), ACADS(5), ACADVL(1), ACSL1(8), ACSL3(8), ACSL4(5), CPT1A(14), CPT2(1), EHHADH(6), HADHA(6), PECR(1), SCP2(4), SLC25A20(2) 6926468 70 55 66 32 45 4 3 7 11 0 0.437 1.000 1.000 473 PHOTOSYNTHESIS ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, FDXR 22 ATP6AP1(3), ATP6V0A1(12), ATP6V0A4(22), ATP6V0D1(1), ATP6V1A(2), ATP6V1B1(4), ATP6V1B2(3), ATP6V1C1(1), ATP6V1C2(7), ATP6V1E1(1), ATP6V1F(1), ATP6V1G2(1), ATP6V1G3(7), ATP6V1H(5), FDXR(9), SHMT1(2) 6549363 81 55 80 49 48 4 5 10 14 0 0.525 1.000 1.000 474 LIMONENE_AND_PINENE_DEGRADATION ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, ECHS1, EHHADH, HADHA, SDS 12 ALDH1A1(5), ALDH1A2(14), ALDH1A3(2), ALDH1B1(11), ALDH2(7), ALDH3A1(8), ALDH3A2(3), ALDH9A1(2), ECHS1(3), EHHADH(6), HADHA(6), SDS(2) 4953689 69 54 65 31 36 9 4 10 10 0 0.140 1.000 1.000 475 P53PATHWAY p53 induces cell cycle arrest or apoptosis under conditions of DNA damage. APAF1, ATM, BAX, BCL2, CCND1, CCNE1, CDK2, CDK4, CDKN1A, E2F1, GADD45A, MDM2, PCNA, RB1, TIMP3, TP53 15 APAF1(6), ATM(15), BAX(3), BCL2(2), CCND1(2), CCNE1(4), CDK4(7), CDKN1A(3), E2F1(5), MDM2(1), PCNA(2), RB1(10), TIMP3(5) 7024276 65 54 61 23 26 6 4 12 15 2 0.290 1.000 1.000 476 RELAPATHWAY Acetylated NF-kB proteins are immune to IkB regulation and promote transcription until the histone deacetylase HDAC3 deacetylates the RelA subunit of NF-kB. CHUK, CREBBP, EP300, FADD, HDAC3, IKBKB, IKBKG, NFKB1, NFKBIA, RELA, RIPK1, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF6 15 CHUK(2), CREBBP(24), EP300(18), HDAC3(5), IKBKB(4), NFKB1(6), NFKBIA(2), RELA(4), RIPK1(3), TNF(1), TNFRSF1A(4), TNFRSF1B(4), TRAF6(4) 9112835 81 54 81 36 44 10 6 13 8 0 0.362 1.000 1.000 477 ST_JAK_STAT_PATHWAY The Janus kinase-signal transducer and activator of transcription (JAK-STAT) pathway transduces extracellular signals to promote gene activation. CISH, JAK1, JAK2, JAK3, PIAS1, PIAS3, PTPRU, REG1A, SOAT1 9 CISH(4), JAK1(6), JAK2(8), JAK3(11), PIAS1(5), PIAS3(6), PTPRU(21), REG1A(7), SOAT1(3) 5574333 71 54 70 30 44 6 2 7 12 0 0.126 1.000 1.000 478 AMINOSUGARS_METABOLISM CMAS, CYB5R3, GCK, GFPT1, GNE, GNPDA1, GNPDA2, HEXA, HEXB, HK1, HK2, HK3, PGM3, RENBP, UAP1 15 CMAS(2), CYB5R3(2), GCK(17), GFPT1(4), GNE(3), GNPDA1(1), GNPDA2(1), HEXA(6), HEXB(4), HK1(3), HK2(13), HK3(14), PGM3(1), RENBP(4), UAP1(2) 6935973 77 53 74 40 51 5 2 11 8 0 0.361 1.000 1.000 479 ARFPATHWAY Cyclin-dependent kinase inhibitor 2A is a tumor suppressor that induces G1 arrest and can activate the p53 pathway, leading to G2/M arrest. ABL1, CDKN2A, E2F1, MDM2, MYC, PIK3CA, PIK3R1, POLR1A, POLR1B, POLR1C, POLR1D, RAC1, RB1, TBX2, TP53, TWIST1 13 ABL1(13), E2F1(5), MDM2(1), MYC(5), PIK3CA(10), PIK3R1(2), POLR1A(13), POLR1B(9), POLR1C(1), RB1(10), TBX2(6), TWIST1(1) 7523342 76 52 74 26 46 7 3 7 10 3 0.0475 1.000 1.000 480 ATP_SYNTHESIS ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H 21 ATP6AP1(3), ATP6V0A1(12), ATP6V0A4(22), ATP6V0D1(1), ATP6V1A(2), ATP6V1B1(4), ATP6V1B2(3), ATP6V1C1(1), ATP6V1C2(7), ATP6V1E1(1), ATP6V1F(1), ATP6V1G2(1), ATP6V1G3(7), ATP6V1H(5), SHMT1(2) 6155240 72 52 71 44 42 3 5 9 13 0 0.566 1.000 1.000 481 EEA1PATHWAY The FYVE-finger proteins EEA1 and HRS are localized to endosome membranes and regulate sorting and ubiquitination in the vesicle transport system. EEA1, EGF, EGFR, HGS, RAB5A, TF, TFRC 7 EEA1(3), EGF(21), EGFR(25), HGS(5), RAB5A(2), TF(16), TFRC(4) 5241527 76 52 76 45 48 5 5 8 10 0 0.819 1.000 1.000 482 FLAGELLAR_ASSEMBLY ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H 21 ATP6AP1(3), ATP6V0A1(12), ATP6V0A4(22), ATP6V0D1(1), ATP6V1A(2), ATP6V1B1(4), ATP6V1B2(3), ATP6V1C1(1), ATP6V1C2(7), ATP6V1E1(1), ATP6V1F(1), ATP6V1G2(1), ATP6V1G3(7), ATP6V1H(5), SHMT1(2) 6155240 72 52 71 44 42 3 5 9 13 0 0.566 1.000 1.000 483 GATA3PATHWAY GATA-3 is a transcription factor that promotes differentiation of helper T cells into Th2 cells, which secrete cytokines IL4, IL5, and IL13. GATA3, IL13, IL4, IL5, JUNB, MAF, MAP2K3, MAPK14, NFATC1, NFATC2, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B 16 GATA3(8), IL13(2), IL4(1), IL5(4), MAF(1), MAP2K3(8), MAPK14(5), NFATC1(16), NFATC2(11), PRKACB(4), PRKACG(11), PRKAR1A(3), PRKAR1B(4), PRKAR2A(1), PRKAR2B(5) 4937832 84 52 81 51 51 10 4 5 14 0 0.518 1.000 1.000 484 HSA00670_ONE_CARBON_POOL_BY_FOLATE Genes involved in one carbon pool by folate ALDH1L1, AMT, ATIC, DHFR, FTCD, GART, MTFMT, MTHFD1, MTHFD1L, MTHFD2, MTHFR, MTHFS, MTR, SHMT1, SHMT2, TYMS 16 ALDH1L1(15), AMT(1), ATIC(5), DHFR(2), FTCD(3), GART(11), MTFMT(2), MTHFD1(10), MTHFD1L(2), MTHFD2(2), MTHFR(3), MTR(11), SHMT1(2), SHMT2(3), TYMS(1) 7738751 73 52 71 41 49 5 3 8 8 0 0.553 1.000 1.000 485 TYPE_III_SECRETION_SYSTEM ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H 21 ATP6AP1(3), ATP6V0A1(12), ATP6V0A4(22), ATP6V0D1(1), ATP6V1A(2), ATP6V1B1(4), ATP6V1B2(3), ATP6V1C1(1), ATP6V1C2(7), ATP6V1E1(1), ATP6V1F(1), ATP6V1G2(1), ATP6V1G3(7), ATP6V1H(5), SHMT1(2) 6155240 72 52 71 44 42 3 5 9 13 0 0.566 1.000 1.000 486 ACTINYPATHWAY The Arp 2/3 complex localizes to the Y-junction of polymerizing actin fibers that enable lamellipod extension and consequent cell motility. ABI-2, ACTA1, ACTR2, ACTR3, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, NCK1, NCKAP1, NTRK1, PIR, PSMA7, RAC1, WASF1, WASF2, WASF3, WASL 17 ACTA1(4), ACTR2(3), ACTR3(2), ARPC1B(3), ARPC2(1), ARPC3(1), NCK1(2), NCKAP1(5), NTRK1(16), PIR(1), WASF1(4), WASF2(5), WASF3(13), WASL(5) 6079680 65 51 64 34 42 5 3 7 8 0 0.770 1.000 1.000 487 CDC42RACPATHWAY PI3 kinase stimulates cell migration by activating cdc42, which activates ARP2/3, which in turn promotes formation of new actin fibers. ACTR2, ACTR3, ARHA, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, CDC42, PAK1, PDGFRA, PIK3CA, PIK3R1, RAC1, WASL 13 ACTR2(3), ACTR3(2), ARPC1B(3), ARPC2(1), ARPC3(1), CDC42(2), PAK1(4), PDGFRA(34), PIK3CA(10), PIK3R1(2), WASL(5) 5322676 67 51 66 30 44 3 2 11 6 1 0.531 1.000 1.000 488 ALKALOID_BIOSYNTHESIS_II ABP1, AOC2, AOC3, CES1, ESD 5 ABP1(22), AOC2(9), AOC3(10), CES1(21), ESD(3) 2462025 65 50 62 38 51 2 4 4 4 0 0.423 1.000 1.000 489 CTLPATHWAY Cytotoxic T lymphocytes induce apoptosis in infected cells presenting antigen-MHC-I complexes via the perforin and Fas/Fas ligand pathways. B2M, CD3D, CD3E, CD3G, CD3Z, GZMB, HLA-A, ICAM1, ITGAL, ITGB2, PRF1, TNFRSF6, TNFSF6, TRA@, TRB@ 10 B2M(4), CD3D(7), CD3E(2), CD3G(1), GZMB(3), HLA-A(3), ICAM1(2), ITGAL(28), ITGB2(16), PRF1(11) 3560073 77 50 76 31 46 7 2 5 17 0 0.0190 1.000 1.000 490 D4GDIPATHWAY D4-GDI inhibits the pro-apoptotic Rho GTPases and is cleaved by caspase-3. ADPRT, APAF1, ARHGAP5, ARHGDIB, CASP1, CASP10, CASP3, CASP8, CASP9, CYCS, GZMB, JUN, PRF1 12 APAF1(6), ARHGAP5(13), ARHGDIB(4), CASP1(10), CASP10(6), CASP3(2), CASP8(9), CASP9(2), CYCS(1), GZMB(3), JUN(1), PRF1(11) 5284597 68 50 66 33 45 5 2 11 5 0 0.604 1.000 1.000 491 ERBB3PATHWAY Neuregulins bind to the receptor tyrosine kinases ErbB3 and ErbB4, surface-localized receptors whose overexpression induces tumor formation. EGF, EGFR, ERBB3, NRG1, UBE2D1 5 EGF(21), EGFR(25), ERBB3(5), NRG1(15), UBE2D1(1) 4229112 67 50 67 42 46 2 3 7 9 0 0.919 1.000 1.000 492 HSA00533_KERATAN_SULFATE_BIOSYNTHESIS Genes involved in keratan sulfate biosynthesis B3GNT1, B3GNT2, B3GNT7, B4GALT1, B4GALT2, B4GALT3, B4GALT4, CHST1, CHST2, CHST4, CHST6, FUT8, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4 16 B3GNT1(3), B3GNT2(2), B3GNT7(6), B4GALT1(2), B4GALT2(2), B4GALT3(2), B4GALT4(3), CHST1(10), CHST2(5), CHST4(10), CHST6(4), FUT8(8), ST3GAL1(7), ST3GAL2(1), ST3GAL3(2), ST3GAL4(2) 5091566 69 50 68 44 43 13 3 5 5 0 0.482 1.000 1.000 493 HSA00602_GLYCOSPHINGOLIPID_BIOSYNTHESIS_NEO_LACTOSERIES Genes involved in glycosphingolipid biosynthesis - neo-lactoseries ABO, B3GNT1, B3GNT2, B3GNT3, B3GNT4, B3GNT5, B4GALT1, B4GALT2, B4GALT3, B4GALT4, FUT1, FUT2, FUT3, FUT4, FUT5, FUT6, FUT7, FUT9, GCNT2, ST3GAL6, ST8SIA1 20 ABO(5), B3GNT1(3), B3GNT2(2), B3GNT3(7), B3GNT4(4), B3GNT5(2), B4GALT1(2), B4GALT2(2), B4GALT3(2), B4GALT4(3), FUT1(3), FUT2(3), FUT3(8), FUT4(4), FUT5(8), FUT6(4), FUT7(2), ST3GAL6(2), ST8SIA1(1) 6249393 67 50 66 39 40 9 4 5 9 0 0.386 1.000 1.000 494 HSA00632_BENZOATE_DEGRADATION_VIA_COA_LIGATION Genes involved in benzoate degradation via CoA ligation ACAT1, ACAT2, ACOT11, ACYP1, ACYP2, ARD1A, CARKL, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ECHS1, EHHADH, ESCO1, ESCO2, FN3K, GCDH, HADHA, ITGB1BP3, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1, YOD1 24 ACAT2(1), ACOT11(10), ACYP1(1), DHRS1(3), DHRS2(8), DHRS3(4), DHRS7(1), DHRSX(6), ECHS1(3), EHHADH(6), ESCO1(2), ESCO2(4), GCDH(6), HADHA(6), ITGB1BP3(1), PNPLA3(3), SH3GLB1(2), YOD1(1) 10658994 68 50 67 41 35 10 5 13 5 0 0.894 1.000 1.000 495 HSA04710_CIRCADIAN_RHYTHM Genes involved in circadian rhythm ARNTL, BHLHB2, BHLHB3, CLOCK, CRY1, CRY2, CSNK1D, CSNK1E, NPAS2, NR1D1, PER1, PER2, PER3 11 ARNTL(6), CLOCK(3), CRY1(6), CRY2(6), CSNK1D(3), CSNK1E(5), NPAS2(7), NR1D1(1), PER1(8), PER2(11), PER3(12) 6941972 68 50 65 44 46 5 1 6 10 0 0.875 1.000 1.000 496 HSP27PATHWAY Hsp27 oligomers have molecular chaperone activity and protect heat-stressed cells against apoptosis. ACTA1, APAF1, BCL2, CASP3, CASP9, CYCS, DAXX, FAS, FASLG, HSPB1, HSPB2, IL1A, MAPKAPK2, MAPKAPK3, TNF, TNFRSF6 15 ACTA1(4), APAF1(6), BCL2(2), CASP3(2), CASP9(2), CYCS(1), DAXX(9), FAS(6), FASLG(15), HSPB1(2), HSPB2(1), IL1A(5), MAPKAPK2(5), MAPKAPK3(5), TNF(1) 4650211 66 50 64 29 44 4 2 7 9 0 0.149 1.000 1.000 497 PELP1PATHWAY Pelp1 acts downstream of activated estrogen receptor to promote cell proliferation and is overexpressed in many breast tumors. CREBBP, EP300, ESR1, MAPK1, MAPK3, PELP1, SRC 7 CREBBP(24), EP300(18), ESR1(6), MAPK1(4), MAPK3(4), PELP1(12), SRC(2) 5996864 70 50 70 33 41 7 5 12 5 0 0.501 1.000 1.000 498 PTENPATHWAY PTEN suppresses AKT-induced cell proliferation and antagonizes the action of PI3K. AKT1, BCAR1, CDKN1B, FOXO3A, GRB2, ILK, ITGB1, MAPK1, MAPK3, PDK2, PDPK1, PIK3CA, PIK3R1, PTEN, PTK2, SHC1, SOS1, TNFSF6 15 AKT1(4), BCAR1(5), CDKN1B(1), GRB2(2), ILK(2), ITGB1(4), MAPK1(4), MAPK3(4), PDK2(4), PDPK1(3), PIK3CA(10), PIK3R1(2), PTK2(7), SHC1(2), SOS1(10) 7507924 64 50 62 35 35 7 3 13 5 1 0.863 1.000 1.000 499 TNFR2PATHWAY Tumor necrosis factor beta, produced by activated lymphocytes, binds to its receptor TNFR2 to induce activation in immune cells and apoptosis in many other cells. CHUK, DUSP1, IKBKAP, IKBKB, IKBKG, LTA, MAP3K1, MAP3K14, NFKB1, NFKBIA, RELA, RIPK1, TANK, TNFAIP3, TNFRSF1B, TRAF1, TRAF2, TRAF3 17 CHUK(2), DUSP1(1), IKBKAP(7), IKBKB(4), LTA(4), MAP3K1(4), MAP3K14(6), NFKB1(6), NFKBIA(2), RELA(4), RIPK1(3), TNFAIP3(2), TNFRSF1B(4), TRAF1(6), TRAF2(2), TRAF3(5) 9109401 62 50 62 50 40 7 1 6 8 0 0.986 1.000 1.000 500 DREAMPATHWAY The transcription factor DREAM blocks expression of the prodynorphin gene, which encodes the ligand of an opioid receptor that blocks pain signaling. CREB1, CREM, CSEN, FOS, JUN, MAPK3, OPRK1, POLR2A, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B 13 FOS(2), JUN(1), MAPK3(4), OPRK1(24), POLR2A(13), PRKACB(4), PRKACG(11), PRKAR1A(3), PRKAR1B(4), PRKAR2A(1), PRKAR2B(5) 5251041 72 49 70 61 51 4 4 6 7 0 0.979 1.000 1.000 501 GLUCOCORTICOID_MINERALOCORTICOID_METABOLISM CPN2, CYP11A1, CYP11B2, CYP17A1, HSD11B1, HSD11B2, HSD3B1, HSD3B2 7 CPN2(12), CYP11A1(14), CYP11B2(14), CYP17A1(7), HSD11B2(3), HSD3B1(14), HSD3B2(14) 2568348 78 49 74 54 56 7 1 4 10 0 0.143 1.000 1.000 502 HSA00400_PHENYLALANINE_TYROSINE_AND_TRYPTOPHAN_BIOSYNTHESIS Genes involved in phenylalanine, tyrosine and tryptophan biosynthesis FARS2, FARSA, FARSB, GOT1, GOT2, PAH, TAT, YARS, YARS2 9 FARS2(6), FARSA(8), FARSB(5), GOT1(6), GOT2(6), PAH(12), TAT(19), YARS(3), YARS2(2) 3563484 67 49 63 26 43 7 2 5 10 0 0.0268 1.000 1.000 503 HYPERTROPHY_MODEL ADAM10, ANKRD1, ATF3, CYR61, DUSP14, EIF4E, EIF4EBP1, GDF8, HBEGF, IFNG, IFRD1, IL18, IL1A, IL1R1, JUND, MYOG, NR4A3, TCF8, VEGF, WDR1 17 ADAM10(8), ANKRD1(1), ATF3(1), CYR61(2), DUSP14(2), EIF4EBP1(1), HBEGF(1), IFNG(4), IFRD1(2), IL18(3), IL1A(5), IL1R1(13), JUND(1), MYOG(3), NR4A3(9), WDR1(6) 4337817 62 49 59 27 41 5 2 5 9 0 0.263 1.000 1.000 504 TALL1PATHWAY APRIL and BAFF bind to BCMA and TACI receptors on B cell surfaces, promoting immunoglobulin production and cell proliferation. CHUK, MAP3K14, MAPK14, MAPK8, NFKB1, RELA, TNFRSF13B, TNFRSF13C, TNFRSF17, TNFSF13, TNFSF13B, TRAF2, TRAF3, TRAF5, TRAF6 15 CHUK(2), MAP3K14(6), MAPK14(5), MAPK8(1), NFKB1(6), RELA(4), TNFRSF13B(10), TNFRSF17(7), TNFSF13B(2), TRAF2(2), TRAF3(5), TRAF5(8), TRAF6(4) 5871211 62 49 62 28 43 7 0 9 3 0 0.290 1.000 1.000 505 IL17PATHWAY Activated T cells secrete IL-17, which stimulates fibroblasts and other cells to secrete inflammatory and hematopoietic cytokines. CD2, CD34, CD3D, CD3E, CD3G, CD3Z, CD4, CD58, CD8A, CSF3, IL17, IL3, IL6, IL8, KITLG, TRA@, TRB@ 13 CD2(27), CD34(4), CD3D(7), CD3E(2), CD3G(1), CD4(8), CD58(1), CD8A(2), CSF3(4), IL3(3), IL6(2), IL8(1), KITLG(11) 2507769 73 48 66 31 51 4 2 8 8 0 0.0420 1.000 1.000 506 IL4PATHWAY IL-4 promotes Th2 cell differentiation via a heterodimeric receptor that activates Stat6/JAK and MAP kinase pathways. AKT1, GRB2, IL2RG, IL4, IL4R, IRS1, JAK1, JAK3, RPS6KB1, SHC1, STAT6 11 AKT1(4), GRB2(2), IL2RG(3), IL4(1), IL4R(16), IRS1(5), JAK1(6), JAK3(11), RPS6KB1(3), SHC1(2), STAT6(8) 6026263 61 48 61 26 34 9 3 8 7 0 0.151 1.000 1.000 507 IL5PATHWAY Pro-inflammatory IL-5 is secretes by activated T cells, eosinophils, and mast cells, and stimulates the proliferation and activation of eosinophils in bone marrow. CCL11, CCR3, CD4, HLA-DRA, HLA-DRB1, IL1B, IL4, IL5, IL5RA, IL6 10 CCL11(3), CCR3(10), CD4(8), HLA-DRA(12), IL1B(8), IL4(1), IL5(4), IL5RA(17), IL6(2) 2184013 65 48 59 33 49 1 1 4 10 0 0.0511 1.000 1.000 508 MITRPATHWAY The MyoD/MEF2 transcription factors induce muscle cell differentiation and are repressed by the transcriptional repressor MITR. CAMK1, CAMK1G, HDAC9, MEF2A, MEF2B, MEF2C, MEF2D, MYOD1, YWHAH 9 CAMK1(5), CAMK1G(11), HDAC9(44), MEF2A(3), MEF2B(2), MEF2C(4), MEF2D(6), MYOD1(1) 3038473 76 48 67 37 61 5 2 3 5 0 0.230 1.000 1.000 509 TRKAPATHWAY Nerve growth factor (NGF) promotes neuronal survival and proliferation by binding its receptor TrkA, which activates PI3K/AKT, Ras, and the MAP kinase pathway. AKT1, DPM2, GRB2, HRAS, KLK2, NGFB, NTRK1, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, SHC1, SOS1 12 AKT1(4), DPM2(1), GRB2(2), HRAS(3), KLK2(5), NTRK1(16), PIK3CA(10), PIK3R1(2), PLCG1(8), PRKCA(8), SHC1(2), SOS1(10) 6355795 71 48 69 39 40 9 3 10 8 1 0.782 1.000 1.000 510 AGPCRPATHWAY G-protein coupled receptors (GPCRs) transduce extracellular signals across the plasma membrane; attenuation occurs by signal molecule degradation or receptor-mediated endocytosis. ARRB1, GNAS, GNB1, GNGT1, GPRK2L, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1 11 ARRB1(5), GNAS(25), GNB1(1), PRKACB(4), PRKACG(11), PRKAR1A(3), PRKAR1B(4), PRKAR2A(1), PRKAR2B(5), PRKCA(8) 3882163 67 47 64 41 43 9 3 6 6 0 0.861 1.000 1.000 511 HSA00100_BIOSYNTHESIS_OF_STEROIDS Genes involved in biosynthesis of steroids CYP27B1, CYP51A1, DHCR24, DHCR7, EBP, FDFT1, FDPS, GGCX, GGPS1, HMGCR, HSD17B7, IDI1, IDI2, LSS, MVD, MVK, NQO1, NSDHL, PMVK, SC4MOL, SC5DL, SQLE, TM7SF2, VKORC1 24 CYP27B1(4), CYP51A1(1), DHCR24(2), DHCR7(10), FDPS(3), GGCX(2), GGPS1(1), HMGCR(12), HSD17B7(1), IDI1(1), IDI2(1), LSS(3), MVD(1), MVK(2), NQO1(2), NSDHL(3), PMVK(2), SC5DL(2), SQLE(3), TM7SF2(5) 7868304 61 47 57 35 27 13 3 10 8 0 0.697 1.000 1.000 512 HSA00440_AMINOPHOSPHONATE_METABOLISM Genes involved in aminophosphonate metabolism CARM1, CHPT1, HEMK1, LCMT1, LCMT2, METTL2B, METTL6, PCYT1A, PCYT1B, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, WBSCR22 16 CARM1(4), CHPT1(1), HEMK1(4), LCMT1(4), LCMT2(1), METTL2B(7), METTL6(1), PCYT1A(3), PCYT1B(9), PRMT2(2), PRMT3(5), PRMT5(7), PRMT7(3), PRMT8(11), WBSCR22(1) 5736524 63 47 62 31 38 9 4 7 5 0 0.341 1.000 1.000 513 ONE_CARBON_POOL_BY_FOLATE ALDH1L1, AMT, ATIC, ATP6V0C, SHMT1, DHFR, GART, MTHFD1, MTHFD1L, MTHFD2, MTHFR, MTHFS, MTR, SHMT1, SHMT2, TYMS 15 ALDH1L1(15), AMT(1), ATIC(5), DHFR(2), GART(11), MTHFD1(10), MTHFD1L(2), MTHFD2(2), MTHFR(3), MTR(11), SHMT1(2), SHMT2(3), TYMS(1) 7307527 68 47 66 34 45 5 3 8 7 0 0.337 1.000 1.000 514 CDC25PATHWAY The protein phosphatase Cdc25 is phosphorylated by Chk1 and activates Cdc2 to stimulate eukaryotic cells into M phase. ATM, CDC2, CDC25A, CDC25B, CDC25C, CHEK1, MYT1, WEE1, YWHAH 8 ATM(15), CDC25A(8), CDC25B(4), CDC25C(5), CHEK1(2), MYT1(21), WEE1(2) 5622971 57 46 55 26 38 4 2 6 7 0 0.498 1.000 1.000 515 HSA00630_GLYOXYLATE_AND_DICARBOXYLATE_METABOLISM Genes involved in glyoxylate and dicarboxylate metabolism ACO1, ACO2, AFMID, CS, GRHPR, HAO1, HAO2, HYI, LOC441996, MDH1, MDH2, MTHFD1, MTHFD1L, MTHFD2 13 ACO1(6), ACO2(5), AFMID(2), CS(2), GRHPR(1), HAO1(8), HAO2(14), HYI(1), MDH1(3), MDH2(3), MTHFD1(10), MTHFD1L(2), MTHFD2(2) 5476565 59 46 56 37 35 4 3 7 10 0 0.672 1.000 1.000 516 HSA00920_SULFUR_METABOLISM Genes involved in sulfur metabolism BPNT1, CHST11, CHST12, CHST13, PAPSS1, PAPSS2, SULT1A1, SULT1A2, SULT1A3, SULT1A4, SULT1E1, SULT2A1, SULT2B1, SUOX 12 CHST11(7), CHST12(5), CHST13(3), PAPSS1(4), PAPSS2(5), SULT1A1(14), SULT1A2(2), SULT1E1(16), SULT2A1(9), SULT2B1(7), SUOX(4) 3727619 76 46 73 38 57 5 0 6 8 0 0.168 1.000 1.000 517 RANKLPATHWAY RANK is a TNF-type receptor that promotes osteoclast differentiation and consequent bone resorbtion on binding RANK ligand produced by osteoblasts. FOS, FOSL1, FOSL2, IFNAR1, IFNAR2, IFNB1, ISGF3G, MAPK8, NFKB1, PRKR, RELA, TNFRSF11A, TNFSF11, TRAF6 12 FOS(2), FOSL2(5), IFNAR1(2), IFNAR2(14), IFNB1(6), MAPK8(1), NFKB1(6), RELA(4), TNFRSF11A(5), TNFSF11(5), TRAF6(4) 4522388 54 46 52 28 36 3 1 7 7 0 0.614 1.000 1.000 518 ST_TYPE_I_INTERFERON_PATHWAY Type I interferon is an antiviral cytokine that induces a JAK-STAT type pathway leading to ISGF3 activation and a cellular antiviral response. IFNAR1, IFNB1, ISGF3G, JAK1, PTPRU, REG1A, STAT1, STAT2, TYK2 8 IFNAR1(2), IFNB1(6), JAK1(6), PTPRU(21), REG1A(7), STAT1(5), STAT2(6), TYK2(8) 5124538 61 46 60 30 35 5 1 8 12 0 0.184 1.000 1.000 519 ACETYLCHOLINE_SYNTHESIS ACHE, CHAT, CHKA, PCYT1A, PDHA1, PDHA2, PEMT, SLC18A3 8 ACHE(8), CHAT(17), CHKA(2), PCYT1A(3), PDHA1(4), PDHA2(20), PEMT(2), SLC18A3(2) 2803968 58 45 54 29 41 7 1 2 7 0 0.138 1.000 1.000 520 CYTOKINEPATHWAY Intercellular signaling in the immune system occurs via secretion of cytokines, which promote antigen-dependent B and T cell response. IFNA1, IFNB1, IFNG, IL10, IL12A, IL12B, IL13, IL14, IL15, IL16, IL17, IL18, IL1A, IL2, IL3, IL4, IL5, IL6, IL8, IL9, LTA, TNF 20 IFNA1(1), IFNB1(6), IFNG(4), IL10(3), IL12A(4), IL12B(3), IL13(2), IL15(3), IL16(12), IL18(3), IL1A(5), IL2(4), IL3(3), IL4(1), IL5(4), IL6(2), IL8(1), IL9(1), LTA(4), TNF(1) 4032502 67 45 64 37 46 3 2 3 13 0 0.141 1.000 1.000 521 HSA00363_BISPHENOL_A_DEGRADATION Genes involved in bisphenol A degradation AKR1B10, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, HSD3B7, PON1, PON2, PON3, RDH11, RDH12, RDH13, RDH14 14 AKR1B10(9), DHRS1(3), DHRS2(8), DHRS3(4), DHRS7(1), DHRSX(6), HSD3B7(5), PON1(21), PON2(2), RDH11(1), RDH12(2), RDH13(3) 3694167 65 45 64 32 47 4 1 6 7 0 0.131 1.000 1.000 522 GLYOXYLATE_AND_DICARBOXYLATE_METABOLISM ACO1, ACO2, CS, GRHPR, HAO1, HAO2, HYI, MDH1, MDH2, MTHFD1, MTHFD1L, MTHFD2 12 ACO1(6), ACO2(5), CS(2), GRHPR(1), HAO1(8), HAO2(14), HYI(1), MDH1(3), MDH2(3), MTHFD1(10), MTHFD1L(2), MTHFD2(2) 5229018 57 44 54 33 34 4 2 7 10 0 0.552 1.000 1.000 523 HSA00430_TAURINE_AND_HYPOTAURINE_METABOLISM Genes involved in taurine and hypotaurine metabolism BAAT, CDO1, CSAD, GAD1, GAD2, GGT1, GGTL3, GGTL4 6 BAAT(13), CDO1(6), CSAD(6), GAD1(13), GAD2(9), GGT1(8) 2316233 55 44 53 31 34 7 4 5 5 0 0.456 1.000 1.000 524 HSA04130_SNARE_INTERACTIONS_IN_VESICULAR_TRANSPORT Genes involved in SNARE interactions in vesicular transport BET1, BET1L, BNIP1, C1orf142, GOSR1, GOSR2, SEC22B, SNAP23, SNAP25, SNAP29, STX10, STX11, STX12, STX16, STX17, STX18, STX19, STX2, STX3, STX4, STX5, STX6, STX7, STX8, TSNARE1, USE1, VAMP1, VAMP2, VAMP3, VAMP4, VAMP5, VAMP7, VAMP8, VTI1A, VTI1B, YKT6 35 BET1(1), BET1L(1), BNIP1(4), GOSR1(2), GOSR2(1), SEC22B(5), SNAP25(8), SNAP29(2), STX10(1), STX11(3), STX12(1), STX16(2), STX17(1), STX19(2), STX2(4), STX3(1), STX4(1), STX5(4), STX6(2), TSNARE1(5), VAMP1(1), VAMP3(1), VAMP4(1), VAMP7(5), VAMP8(1), VTI1A(1), VTI1B(1) 6765023 62 44 59 33 36 5 1 11 9 0 0.412 1.000 1.000 525 CD40PATHWAY The CD40 receptor is a TNF-type receptor that regulates immunoglobulin expression in B cells and moderates T cell activation via T-cell expression of its ligand. CHUK, DUSP1, IKBKAP, IKBKB, IKBKG, MAP3K1, MAP3K14, NFKB1, NFKBIA, RELA, TNFAIP3, TNFRSF5, TNFSF5, TRAF3, TRAF6 12 CHUK(2), DUSP1(1), IKBKAP(7), IKBKB(4), MAP3K1(4), MAP3K14(6), NFKB1(6), NFKBIA(2), RELA(4), TNFAIP3(2), TRAF3(5), TRAF6(4) 7369551 47 43 47 35 29 7 1 5 5 0 0.962 1.000 1.000 526 MALATEXPATHWAY The tricarboxylate transfer pathway shuttles acetyl groups of acetyl-CoA between mitochondria and the cytoplasm. ACLY, CS, MDH1, ME1, PC, PDHA1, SLC25A1, SLC25A11 8 ACLY(10), CS(2), MDH1(3), ME1(20), PC(14), PDHA1(4), SLC25A11(4) 3807777 57 43 55 29 36 6 2 8 4 1 0.242 1.000 1.000 527 1_2_DICHLOROETHANE_DEGRADATION ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1 8 ALDH1A1(5), ALDH1A2(14), ALDH1A3(2), ALDH1B1(11), ALDH2(7), ALDH3A1(8), ALDH3A2(3), ALDH9A1(2) 3251670 52 42 49 22 26 6 4 8 8 0 0.112 1.000 1.000 528 ACETAMINOPHENPATHWAY Acetaminophen selectively inhibits Cox-3, which is localized to the brain, and yields the toxic metabolite NAPQI when processed by CAR in the liver. CYP1A2, CYP2E1, CYP3A, NR1I3, PTGS1, PTGS2 5 CYP1A2(8), CYP2E1(13), NR1I3(6), PTGS1(20), PTGS2(13) 2203556 60 42 58 34 45 5 0 2 8 0 0.202 1.000 1.000 529 ASCORBATE_AND_ALDARATE_METABOLISM ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1 8 ALDH1A1(5), ALDH1A2(14), ALDH1A3(2), ALDH1B1(11), ALDH2(7), ALDH3A1(8), ALDH3A2(3), ALDH9A1(2) 3251670 52 42 49 22 26 6 4 8 8 0 0.112 1.000 1.000 530 CHONDROITIN B3GAT3, B4GALT7, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, XYLT1, XYLT2 8 B3GAT3(4), HS3ST1(10), HS3ST2(9), HS3ST3A1(6), HS3ST3B1(2), XYLT1(12), XYLT2(4) 2613269 47 42 47 41 30 6 0 7 4 0 0.863 1.000 1.000 531 HEPARAN_SULFATE_BIOSYNTHESIS B3GAT3, B4GALT7, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, XYLT1, XYLT2 8 B3GAT3(4), HS3ST1(10), HS3ST2(9), HS3ST3A1(6), HS3ST3B1(2), XYLT1(12), XYLT2(4) 2613269 47 42 47 41 30 6 0 7 4 0 0.863 1.000 1.000 532 MITOCHONDRIAPATHWAY Pro-apoptotic signaling induces mitochondria to release cytochrome c, which stimulates Apaf-1 to activate caspase 9. APAF1, BAK1, BAX, BCL2, BCL2L1, BID, BIK, BIRC2, BIRC3, BIRC4, CASP3, CASP6, CASP7, CASP8, CASP9, CYCS, DFFA, DFFB, DIABLO, ENDOG, PDCD8 18 APAF1(6), BAK1(1), BAX(3), BCL2(2), BIK(2), BIRC2(6), BIRC3(7), CASP3(2), CASP7(4), CASP8(9), CASP9(2), CYCS(1), DFFA(2), DFFB(2), DIABLO(2) 5510376 51 42 50 18 25 4 6 6 10 0 0.259 1.000 1.000 533 ST_INTERFERON_GAMMA_PATHWAY The interferon gamma pathway resembles the JAK-STAT pathway and activates STAT transcription factors. CISH, IFNG, IFNGR1, JAK1, JAK2, PLA2G2A, PTPRU, REG1A, STAT1, STATIP1 9 CISH(4), IFNG(4), IFNGR1(3), JAK1(6), JAK2(8), PLA2G2A(2), PTPRU(21), REG1A(7), STAT1(5) 4661779 60 42 59 23 35 3 1 7 14 0 0.0989 1.000 1.000 534 EPONFKBPATHWAY The cytokine erythropoietin (Epo) prevents stress-induced neuronal apoptosis by stimulating anti-apoptotic pathways through JAK2 kinase and NF-kB. ARNT, CDKN1A, EPO, EPOR, GRIN1, HIF1A, JAK2, NFKB1, NFKBIA, RELA, SOD2 11 ARNT(9), CDKN1A(3), EPO(5), EPOR(1), GRIN1(8), HIF1A(4), JAK2(8), NFKB1(6), NFKBIA(2), RELA(4) 5119098 50 41 49 24 22 6 5 7 10 0 0.576 1.000 1.000 535 HSA00521_STREPTOMYCIN_BIOSYNTHESIS Genes involved in streptomycin biosynthesis GCK, HK1, HK2, HK3, IMPA1, IMPA2, ISYNA1, PGM1, PGM3, TGDS 10 GCK(17), HK1(3), HK2(13), HK3(14), IMPA1(1), IMPA2(4), ISYNA1(1), PGM1(6), PGM3(1), TGDS(1) 4760785 61 41 59 37 43 5 2 5 6 0 0.412 1.000 1.000 536 S1PPATHWAY At low cholesterol concentrations, sterol-regulatory element binding proteins (SREBPs) act as transcription factors to promote cholesterol uptake and biosynthesis. EPLIN, HMGCS1, LDLR, MBTPS1, MBTPS2, SCAP, SREBF1, SREBF2 7 HMGCS1(3), LDLR(17), MBTPS1(7), MBTPS2(4), SCAP(10), SREBF1(5), SREBF2(10) 4848049 56 41 54 31 36 3 4 9 4 0 0.482 1.000 1.000 537 SARSPATHWAY The SARS coronavirus has a 30kb RNA genome containing rep, a large gene encoding viral protease Mpro. ANPEP, CKM, EIF4E, FBL, GPT, LDHA, LDHB, LDHC, MAPK14, NCL 10 ANPEP(24), CKM(3), FBL(1), GPT(3), LDHA(4), LDHB(2), LDHC(5), MAPK14(5), NCL(6) 3674922 53 41 51 26 36 4 6 4 3 0 0.346 1.000 1.000 538 IFNAPATHWAY Interferon alpha, active in the immune response, binds to the IFN receptor and activates Jak1 and Tyk2, which phosphorylate Stat1 and Stat2. IFNA1, IFNAR1, IFNAR2, IFNB1, ISGF3G, JAK1, STAT1, STAT2, TYK2 8 IFNA1(1), IFNAR1(2), IFNAR2(14), IFNB1(6), JAK1(6), STAT1(5), STAT2(6), TYK2(8) 4413195 48 40 47 21 29 3 2 7 7 0 0.206 1.000 1.000 539 SELENOAMINO_ACID_METABOLISM AHCY, CBS, CTH, GGT1, MARS, MARS2, MAT1A, MAT2B, PAPSS1, PAPSS2, SCLY, SEPHS1 12 AHCY(5), CBS(7), CTH(1), GGT1(8), MARS(7), MARS2(4), MAT1A(6), MAT2B(1), PAPSS1(4), PAPSS2(5), SCLY(4), SEPHS1(2) 5089670 54 40 54 23 33 4 4 5 8 0 0.104 1.000 1.000 540 ST_IL_13_PATHWAY Like IL-4, IL-13 is produced by Th2 cells on activation of the T cell antigen receptor, and by mast and basophil cells on activation of the IgE receptor. IL13, IL13RA1, IL13RA2, IL4R, JAK1, JAK2, TYK2 7 IL13(2), IL13RA1(3), IL13RA2(5), IL4R(16), JAK1(6), JAK2(8), TYK2(8) 4275672 48 40 48 23 31 2 2 8 5 0 0.492 1.000 1.000 541 ST_INTERLEUKIN_13_PATHWAY IL-13 is produced by Th2 cells on activation of the T cell antigen receptor, and by mast and basophil cells on activation of the IgE receptor. IL13, IL13RA1, IL13RA2, IL4R, JAK1, JAK2, TYK2 7 IL13(2), IL13RA1(3), IL13RA2(5), IL4R(16), JAK1(6), JAK2(8), TYK2(8) 4275672 48 40 48 23 31 2 2 8 5 0 0.492 1.000 1.000 542 TSP1PATHWAY Thrombospondin-1 (TSP-1) inhibits angiogenesis by inducing caspase-dependent apoptosis in microvascular endothelial cells. CASP3, CD36, FOS, FYN, JUN, MAPK14, THBS1 7 CASP3(2), CD36(6), FOS(2), FYN(7), JUN(1), MAPK14(5), THBS1(30) 3026929 53 40 52 33 34 2 2 6 9 0 0.854 1.000 1.000 543 TOB1PATHWAY TGF-beta signaling activates SMADs, which interact with intracellular Tob to maintain unstimulated T cells by repressing IL-2 expression. CD28, CD3D, CD3E, CD3G, CD3Z, IFNG, IL2, IL2RA, IL4, MADH3, MADH4, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TGFBR3, TOB1, TOB2, TRA@, TRB@ 16 CD28(2), CD3D(7), CD3E(2), CD3G(1), IFNG(4), IL2(4), IL2RA(5), IL4(1), TGFB1(2), TGFB2(3), TGFB3(3), TGFBR2(9), TGFBR3(8), TOB1(3), TOB2(3) 4303162 57 39 57 27 43 2 1 1 10 0 0.189 1.000 1.000 544 HSA00053_ASCORBATE_AND_ALDARATE_METABOLISM Genes involved in ascorbate and aldarate metabolism ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, MIOX, UGDH 9 ALDH1A3(2), ALDH1B1(11), ALDH2(7), ALDH3A1(8), ALDH3A2(3), ALDH7A1(9), ALDH9A1(2), MIOX(4), UGDH(1) 3461289 47 38 45 24 23 6 6 5 7 0 0.342 1.000 1.000 545 IL10PATHWAY The cytokine IL-10 inhibits the inflammatory response by macrophages via activation of heme oxygenase 1. BLVRA, BLVRB, HMOX1, IL10, IL10RA, IL10RB, IL1A, IL6, JAK1, STAT1, STAT3, STAT5A, TNF 13 BLVRA(2), BLVRB(1), HMOX1(1), IL10(3), IL10RA(9), IL1A(5), IL6(2), JAK1(6), STAT1(5), STAT3(9), STAT5A(3), TNF(1) 4988544 47 38 46 28 25 5 5 6 6 0 0.446 1.000 1.000 546 STEMPATHWAY In the absence of infection, bone marrow stromal cells release hematopoietic cytokines; activated macrophages and Th cells induce hematopoiesis during infection. CD4, CD8A, CSF1, CSF2, CSF3, EPO, IL11, IL2, IL3, IL4, IL5, IL6, IL7, IL8, IL9 15 CD4(8), CD8A(2), CSF1(12), CSF2(2), CSF3(4), EPO(5), IL11(3), IL2(4), IL3(3), IL4(1), IL5(4), IL6(2), IL7(4), IL8(1), IL9(1) 2469279 56 38 54 35 38 3 1 6 8 0 0.300 1.000 1.000 547 STREPTOMYCIN_BIOSYNTHESIS GCK, HK1, HK2, HK3, IMPA1, PGM1, PGM3, TGDS 8 GCK(17), HK1(3), HK2(13), HK3(14), IMPA1(1), PGM1(6), PGM3(1), TGDS(1) 4181851 56 38 54 32 40 5 2 4 5 0 0.351 1.000 1.000 548 CHOLESTEROL_BIOSYNTHESIS C10orf110, CYP51A1, DHCR7, FDFT1, FDPS, FDPS, LOC402397, HMGCR, HMGCS1, IDI1, LSS, MVD, MVK, NSDHL, PMVK, SC4MOL, SC5DL, SQLE 15 CYP51A1(1), DHCR7(10), FDPS(3), HMGCR(12), HMGCS1(3), IDI1(1), LSS(3), MVD(1), MVK(2), NSDHL(3), PMVK(2), SC5DL(2), SQLE(3) 5372303 46 37 42 26 19 9 2 9 7 0 0.819 1.000 1.000 549 HSA00062_FATTY_ACID_ELONGATION_IN_MITOCHONDRIA Genes involved in fatty acid elongation in mitochondria ACAA2, ECHS1, HADH, HADHA, HADHB, HSD17B10, HSD17B4, MECR, PPT1, PPT2 10 ACAA2(1), ECHS1(3), HADH(2), HADHA(6), HADHB(5), HSD17B10(2), HSD17B4(6), MECR(5), PPT1(4), PPT2(5) 3470568 39 37 38 16 21 4 4 6 4 0 0.333 1.000 1.000 550 PLK3PATHWAY Active Plk3 phosphorylates CDC25c, blocking the G2/M transition, and phosphorylates p53 to induce apoptosis. ATM, ATR, CDC25C, CHEK1, CHEK2, CNK, TP53, YWHAH 6 ATM(15), ATR(23), CDC25C(5), CHEK1(2), CHEK2(2) 6190357 47 37 46 23 35 2 1 4 5 0 0.768 1.000 1.000 551 RNA_POLYMERASE POLR1B, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLRMT 14 POLR1B(9), POLR2A(13), POLR2B(12), POLR2C(1), POLR2D(1), POLR2E(3), POLR2F(1), POLR2H(2), POLR2J(1), POLRMT(3) 5474255 46 37 44 23 27 4 2 7 6 0 0.429 1.000 1.000 552 STAT3PATHWAY The STAT transcription factors are phosphorylated and activated by JAK kinases in response to cytokine signaling. FRAP1, JAK1, JAK2, JAK3, MAPK1, MAPK3, STAT3, TYK2 7 JAK1(6), JAK2(8), JAK3(11), MAPK1(4), MAPK3(4), STAT3(9), TYK2(8) 4757093 50 37 50 36 26 7 4 8 5 0 0.898 1.000 1.000 553 HSA00603_GLYCOSPHINGOLIPID_BIOSYNTHESIS_GLOBOSERIES Genes involved in glycosphingolipid biosynthesis - globoseries A4GALT, B3GALNT1, B3GALT5, FUT1, FUT2, FUT9, GBGT1, GLA, HEXA, HEXB, NAGA, ST3GAL1, ST3GAL2, ST8SIA1 13 A4GALT(7), B3GALNT1(6), B3GALT5(1), FUT1(3), FUT2(3), GLA(2), HEXA(6), HEXB(4), NAGA(5), ST3GAL1(7), ST3GAL2(1), ST8SIA1(1) 4111026 46 36 44 33 27 4 2 9 4 0 0.790 1.000 1.000 554 SETPATHWAY Cytotoxic T cells release perforin, which to allow entry into target cells of granzyme B, which activates caspases, and granzyme A, which induces caspase-independent apoptosis. ANP32A, APEX1, CREBBP, DFFA, DFFB, GZMA, GZMB, HMGB2, NME1, PRF1, SET 10 ANP32A(3), CREBBP(24), DFFA(2), DFFB(2), GZMB(3), HMGB2(1), PRF1(11), SET(3) 4111354 49 36 49 22 26 6 4 8 5 0 0.403 1.000 1.000 555 AKAP13PATHWAY A-kinase anchor protein 13 (AKAP13) localizes protein kinase A holoenzyme and is a nucleotide exchange factor for Rho/Rac. AKAP13, ARHA, EDG2, EDG4, EDG7, GNA12, PRKACB, PRKACG, PRKAG1, PRKAR2A, PRKAR2B 7 AKAP13(20), GNA12(3), PRKACB(4), PRKACG(11), PRKAG1(3), PRKAR2A(1), PRKAR2B(5) 4129592 47 35 47 28 31 4 1 5 6 0 0.730 1.000 1.000 556 EIF2PATHWAY Eukaryotic initiation factor 2 (EIF2) initiates translation by transferring Met-tRNA to the 40S ribosome in a GTP-dependent process. EIF2AK3, EIF2AK4, EIF2B5, EIF2S1, EIF2S2, EIF2S3, EIF5, GSK3B, HRI, PPP1CA, PRKR 9 EIF2AK3(16), EIF2AK4(14), EIF2B5(2), EIF2S1(1), EIF2S3(1), EIF5(2), GSK3B(3), PPP1CA(1) 4744568 40 35 39 19 21 2 1 13 3 0 0.752 1.000 1.000 557 HSA03050_PROTEASOME Genes involved in proteasome PSMA1, PSMA2, PSMA3, PSMA4, PSMA5, PSMA6, PSMA7, PSMB1, PSMB2, PSMB3, PSMB4, PSMB5, PSMB6, PSMB7, PSMC2, PSMC3, PSMD1, PSMD11, PSMD12, PSMD13, PSMD2, PSMD6 22 PSMA1(4), PSMA4(2), PSMA5(3), PSMA6(4), PSMB1(1), PSMB2(1), PSMB4(1), PSMB5(1), PSMB6(1), PSMB7(2), PSMC2(2), PSMC3(3), PSMD1(6), PSMD12(2), PSMD13(3), PSMD2(4), PSMD6(1) 6591013 41 35 40 19 24 4 2 7 4 0 0.470 1.000 1.000 558 NUCLEOTIDE_GPCRS ADORA1, ADORA2A, ADORA2B, ADORA3, GPR23, LTB4R, P2RY1, P2RY2, P2RY5, P2RY6 8 ADORA1(6), ADORA2A(3), ADORA2B(1), ADORA3(15), LTB4R(1), P2RY1(5), P2RY2(8), P2RY6(2) 2438743 41 35 41 33 25 6 2 5 3 0 0.321 1.000 1.000 559 UBIQUITIN_MEDIATED_PROTEOLYSIS CDC34, HIP2, NRF1, UBE1, UBE2A, UBE2B, UBE2C, UBE2D1, UBE2D2, UBE2D3, UBE2E1, UBE2E3, UBE2G1, UBE2G2, UBE2G2, TAX1BP3, UBE2H, UBE2I, UBE2J1, UBE2J2, UBE2L3, UBE2L6, UBE2M, UBE2N, UBE2S, UBE3A 23 CDC34(3), NRF1(7), TAX1BP3(1), UBE2A(1), UBE2D1(1), UBE2D3(2), UBE2E1(1), UBE2E3(1), UBE2G2(1), UBE2H(1), UBE2I(2), UBE2J1(1), UBE2J2(8), UBE2L3(1), UBE2L6(1), UBE2M(1), UBE2N(1), UBE2S(2), UBE3A(7) 4323556 43 35 41 19 29 5 2 4 3 0 0.387 1.000 1.000 560 BIOSYNTHESIS_OF_STEROIDS DHCR7, FDFT1, FDPS, FDPS, LOC402397, HMGCR, IDI1, LSS, MVD, MVK, NQO1, NQO2, PMVK, SC5DL, SQLE, VKORC1 14 DHCR7(10), FDPS(3), HMGCR(12), IDI1(1), LSS(3), MVD(1), MVK(2), NQO1(2), NQO2(1), PMVK(2), SC5DL(2), SQLE(3) 4495525 42 34 38 24 17 7 1 9 8 0 0.767 1.000 1.000 561 HSA00601_GLYCOSPHINGOLIPID_BIOSYNTHESIS_LACTOSERIES Genes involved in glycosphingolipid biosynthesis - lactoseries ABO, B3GALT1, B3GALT2, B3GALT5, B3GNT5, FUT1, FUT2, FUT3, ST3GAL3, ST3GAL4 10 ABO(5), B3GALT1(14), B3GALT2(1), B3GALT5(1), B3GNT5(2), FUT1(3), FUT2(3), FUT3(8), ST3GAL3(2), ST3GAL4(2) 2934626 41 34 41 28 28 5 1 3 4 0 0.642 1.000 1.000 562 GLYCOLYSISPATHWAY Glycolysis is an evolutionarily conserved pathway by which one glucose molecule is converted to two pyruvate molecules for a gain of 2 ATP. ALDOB, ENO1, GAPD, GPI, HK1, PFKL, PGAM1, PGK1, PKLR, TPI1 9 ALDOB(14), ENO1(4), GPI(3), HK1(3), PFKL(4), PGK1(2), PKLR(13), TPI1(1) 3756666 44 33 41 21 30 4 1 4 5 0 0.0672 1.000 1.000 563 GLOBOSIDE_METABOLISM A4GALT, FUT1, FUT2, FUT9, GBGT1, GLA, HEXA, HEXB, NAGA, SIAT4A, SIAT4B, ST3GAL1, ST3GAL2, ST3GAL4, ST8SIA1 12 A4GALT(7), FUT1(3), FUT2(3), GLA(2), HEXA(6), HEXB(4), NAGA(5), ST3GAL1(7), ST3GAL2(1), ST3GAL4(2), ST8SIA1(1) 3854399 41 32 39 24 23 4 0 9 5 0 0.505 1.000 1.000 564 MTA3PATHWAY The estrogen receptor regulates proliferation in mammary epithelia via MTA3 activation; loss of either protein is implicated in breast cancer. ALDOA, CTSD, ESR1, GAPD, GREB1, HSPB1, HSPB2, MTA1, MTA3, PDZK1, TUBA1, TUBA2, TUBA3, TUBA4, TUBA6, TUBA8 10 ALDOA(2), CTSD(3), ESR1(6), GREB1(19), HSPB1(2), HSPB2(1), MTA1(2), MTA3(2), PDZK1(4), TUBA8(5) 4368632 46 31 45 27 32 2 4 4 4 0 0.432 1.000 1.000 565 NUCLEOTIDE_METABOLISM ADSL, ADSS, DHFR, HPRT1, IMPDH1, MTHFD2, NME2, OAZ1, POLA, POLB, POLD1, POLG, PRPS2, RRM1, SAT, SRM 14 ADSL(5), ADSS(1), DHFR(2), IMPDH1(4), MTHFD2(2), POLB(1), POLD1(7), POLG(9), PRPS2(2), RRM1(3), SRM(1) 5083641 37 31 37 32 21 4 2 6 4 0 0.972 1.000 1.000 566 SRCRPTPPATHWAY Activation of Src by Protein-tyrosine phosphatase alpha CCNB1, CDC2, CDC25A, CDC25B, CDC25C, CSK, GRB2, PRKCA, PRKCB1, PTPRA, SRC 9 CDC25A(8), CDC25B(4), CDC25C(5), CSK(1), GRB2(2), PRKCA(8), PTPRA(9), SRC(2) 3795692 39 31 38 24 25 5 1 4 4 0 0.658 1.000 1.000 567 HSA00072_SYNTHESIS_AND_DEGRADATION_OF_KETONE_BODIES Genes involved in synthesis and degradation of ketone bodies ACAT1, ACAT2, BDH1, BDH2, HMGCL, HMGCS1, HMGCS2, OXCT1, OXCT2 9 ACAT2(1), BDH1(5), HMGCL(4), HMGCS1(3), HMGCS2(21), OXCT1(4), OXCT2(5) 2922023 43 30 40 20 25 5 2 6 5 0 0.441 1.000 1.000 568 PROTEASOMEPATHWAY Ubiquitinated proteins are targeted for proteolytic degradation by the proteasome, where they are unfolded and degraded to small peptides in an ATP-dependent process. PSMA1, PSMA2, PSMA3, PSMA4, PSMA5, PSMA6, PSMA7, PSMB1, PSMB2, PSMB3, PSMB4, PSMB5, PSMB6, PSMB7, PSMC3, PSMD14, RPN1, RPN2, UBE1, UBE2A, UBE3A 20 PSMA1(4), PSMA4(2), PSMA5(3), PSMA6(4), PSMB1(1), PSMB2(1), PSMB4(1), PSMB5(1), PSMB6(1), PSMB7(2), PSMC3(3), RPN2(4), UBE2A(1), UBE3A(7) 5297746 35 30 35 20 22 3 2 5 3 0 0.719 1.000 1.000 569 AHSPPATHWAY Alpha-hemoglobin stabilizing protein (AHSP) prevents precitipation of hemoglobin alpha-subunits. ALAD, ALAS1, ALAS2, CPO, ERAF, FECH, GATA1, HBA1, HBA2, HBB, HMBS, UROD, UROS 12 ALAD(5), ALAS1(2), ALAS2(5), CPO(4), FECH(3), GATA1(4), HBA1(1), HBB(7), HMBS(1), UROS(1) 3156599 33 29 32 18 25 2 0 2 4 0 0.380 1.000 1.000 570 HSA00642_ETHYLBENZENE_DEGRADATION Genes involved in ethylbenzene degradation ARD1A, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ESCO1, ESCO2, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1 12 DHRS1(3), DHRS2(8), DHRS3(4), DHRS7(1), DHRSX(6), ESCO1(2), ESCO2(4), PNPLA3(3), SH3GLB1(2) 6805199 33 29 33 21 17 3 3 7 3 0 0.923 1.000 1.000 571 MSPPATHWAY Macrophage stimulating protein is synthesized as pro-MSP by the liver and, on proteolysis, binds to monocyte receptor kinase RON to induce macrophage development. CCL2, CSF1, IL1B, MST1, MST1R, TNF 6 CCL2(2), CSF1(12), IL1B(8), MST1(2), MST1R(11), TNF(1) 2679674 36 29 35 31 25 3 1 4 3 0 0.955 1.000 1.000 572 SODDPATHWAY Some members of the tumor necrosis factor receptor family have cytoplasmic death domains that promote apoptosis when active and are repressed by silencers called SODDs. BAG4, BIRC3, CASP8, FADD, RIPK1, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF2 10 BAG4(3), BIRC3(7), CASP8(9), RIPK1(3), TNF(1), TNFRSF1A(4), TNFRSF1B(4), TRAF2(2) 3359842 33 29 33 14 22 1 2 3 5 0 0.274 1.000 1.000 573 ST_G_ALPHA_S_PATHWAY The G-alpha-s protein activates adenylyl cyclases, which catalyze cAMP formation. ASAH1, BF, BFAR, BRAF, CAMP, CREB1, CREB3, CREB5, EPAC, GAS, GRF2, MAPK1, RAF1, SNX13, SRC, TERF2IP 11 BFAR(1), CAMP(2), CREB3(1), CREB5(9), MAPK1(4), RAF1(10), SNX13(5), SRC(2), TERF2IP(1) 3946009 35 29 34 31 23 3 1 5 3 0 0.990 1.000 1.000 574 CIRCADIANPATHWAY A heterodimer composed of Bmal1 and Clock acts as a transcription factor for proteins that regulate circadian rhythms, such as Per and Cry. ARNTL, CLOCK, CRY1, CRY2, CSNK1E, PER1 6 ARNTL(6), CLOCK(3), CRY1(6), CRY2(6), CSNK1E(5), PER1(8) 3449205 34 28 34 18 23 3 1 3 4 0 0.668 1.000 1.000 575 P27PATHWAY p27 blocks the G1/S transition by inhibiting the checkpoint kinase cdk2/cyclin E and is inhibited by cdk2-mediated ubiquitination. CCNE1, CDK2, CDKN1B, CKS1B, CUL1, E2F1, NEDD8, RB1, RBX1, SKP1A, SKP2, TFDP1, UBE2M 12 CCNE1(4), CDKN1B(1), CUL1(5), E2F1(5), RB1(10), SKP2(2), TFDP1(2), UBE2M(1) 3510696 30 28 30 13 12 2 4 4 6 2 0.417 1.000 1.000 576 RANPATHWAY RanGEF (aka RCC1) and RanGFP regulate the GTP- or GDP-bound state of Ran, creating a Ran gradient across the nuclear membrane that is used in nuclear import. CHC1, RAN, RANBP1, RANBP2, RANGAP1 4 RAN(1), RANBP2(28), RANGAP1(3) 3483587 32 28 30 14 21 2 1 3 5 0 0.685 1.000 1.000 577 BLOOD_GROUP_GLYCOLIPID_BIOSYNTHESIS_LACTOSERIES ABO, FUT1, FUT2, FUT3, FUT5, FUT6, SIAT6, ST3GAL3 7 ABO(5), FUT1(3), FUT2(3), FUT3(8), FUT5(8), FUT6(4), ST3GAL3(2) 2047913 33 27 33 20 18 5 2 3 5 0 0.324 1.000 1.000 578 DNAFRAGMENTPATHWAY DNA fragmentation during apoptosis is effected by DFF, a caspase-activated DNAse, and by endonuclease G. CASP3, CASP7, DFFA, DFFB, ENDOG, GZMB, HMGB1, HMGB2, TOP2A, TOP2B 9 CASP3(2), CASP7(4), DFFA(2), DFFB(2), GZMB(3), HMGB1(1), HMGB2(1), TOP2A(11), TOP2B(9) 3623534 35 27 34 13 23 2 4 3 3 0 0.397 1.000 1.000 579 FATTY_ACID_BIOSYNTHESIS_PATH_2 ACAA1, ACAA2, ACAT1, ACAT2, ECHS1, EHHADH, HADHA, HADHB, SDS 9 ACAA1(6), ACAA2(1), ACAT2(1), ECHS1(3), EHHADH(6), HADHA(6), HADHB(5), SDS(2) 3418196 30 27 29 17 19 4 1 2 4 0 0.683 1.000 1.000 580 KERATAN_SULFATE_BIOSYNTHESIS B3GNT1, B4GALT1, B4GALT2, B4GALT3, B4GALT5, FUT8, SIAT4A, SIAT4B, SIAT6, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4 10 B3GNT1(3), B4GALT1(2), B4GALT2(2), B4GALT3(2), B4GALT5(2), FUT8(8), ST3GAL1(7), ST3GAL2(1), ST3GAL3(2), ST3GAL4(2) 3214622 31 27 31 19 16 6 2 4 3 0 0.724 1.000 1.000 581 SA_G1_AND_S_PHASES Cdk2, 4, and 6 bind cyclin D in G1, while cdk2/cyclin E promotes the G1/S transition. ARF1, ARF3, CCND1, CDK2, CDK4, CDKN1A, CDKN1B, CDKN2A, CFL1, E2F1, E2F2, MDM2, NXT1, PRB1, TP53 12 CCND1(2), CDK4(7), CDKN1A(3), CDKN1B(1), CFL1(2), E2F1(5), E2F2(5), MDM2(1), NXT1(2) 2602327 28 27 25 14 15 3 0 5 5 0 0.420 1.000 1.000 582 HSA00720_REDUCTIVE_CARBOXYLATE_CYCLE Genes involved in reductive carboxylate cycle (CO2 fixation) ACLY, ACO1, ACO2, ACSS1, ACSS2, FH, IDH1, IDH2, LOC441996, MDH1, MDH2, SUCLA2 10 ACLY(10), ACO1(6), ACO2(5), ACSS1(2), ACSS2(4), FH(3), IDH2(1), MDH1(3), MDH2(3) 5120354 37 26 36 32 24 0 1 5 7 0 0.959 1.000 1.000 583 LDLPATHWAY Low density lipoproteins (LDL) are present in blood plasma, contain cholesterol and triglycerides, and contribute to atherogenic plaque formation. ACAT1, CCL2, CSF1, IL6, LDLR, LPL 6 CCL2(2), CSF1(12), IL6(2), LDLR(17), LPL(6) 2192207 39 26 38 19 24 6 2 6 1 0 0.305 1.000 1.000 584 PTC1PATHWAY The binding of extracellular signaling protein Sonic hedgehog to the Patched receptor (Ptc1) allows progression through G1 and may inhibit the G2/M transition. CCNB1, CCNH, CDC2, CDC25A, CDC25B, CDC25C, CDK7, MNAT1, PTCH, SHH, XPO1 9 CCNH(2), CDC25A(8), CDC25B(4), CDC25C(5), CDK7(2), MNAT1(2), SHH(3), XPO1(3) 3563330 29 26 29 11 17 3 3 5 1 0 0.358 1.000 1.000 585 ARENRF2PATHWAY Nrf1 and nrf2 are transcription factors that bind to antioxidant response elements (AREs), promoters of genes involved in oxidative damage control. CREB1, FOS, FXYD2, JUN, KEAP1, MAFF, MAFG, MAFK, MAPK1, MAPK14, MAPK8, NFE2L2, PRKCA, PRKCB1 13 FOS(2), JUN(1), KEAP1(2), MAFG(2), MAPK1(4), MAPK14(5), MAPK8(1), NFE2L2(4), PRKCA(8) 3619417 29 25 27 16 18 2 0 4 5 0 0.670 1.000 1.000 586 HBXPATHWAY Hbx is a hepatitis B protein that activates a number of transcription factors, possibly by inducing calcium release from the mitochondrion to the cytoplasm. CREB1, GRB2, HBXIP, HRAS, PTK2B, SHC1, SOS1, SRC 8 GRB2(2), HBXIP(1), HRAS(3), PTK2B(10), SHC1(2), SOS1(10), SRC(2) 3598297 30 25 30 26 21 2 0 5 2 0 0.989 1.000 1.000 587 IONPATHWAY Activated phospholipase C hydrolyzes the lipid PIP3 into second messengers DAG, which activates protein kinase C, and IP3, which induces calcium influx into the cytoplasm. P2RY2, PLCG1, PRKCA, PRKCB1, PTK2B 4 P2RY2(8), PLCG1(8), PRKCA(8), PTK2B(10) 2763332 34 25 33 31 26 4 1 0 3 0 0.828 1.000 1.000 588 HSA00730_THIAMINE_METABOLISM Genes involved in thiamine metabolism LHPP, MTMR1, MTMR2, MTMR6, NFS1, PHPT1, THTPA, TPK1 8 LHPP(1), MTMR1(5), MTMR2(2), MTMR6(2), NFS1(4), TPK1(10) 2614587 24 23 24 11 15 1 2 0 6 0 0.640 1.000 1.000 589 HSA00750_VITAMIN_B6_METABOLISM Genes involved in vitamin B6 metabolism AOX1, PDXK, PDXP, PNPO, PSAT1 5 AOX1(26), PNPO(1), PSAT1(3) 1991228 30 23 28 21 24 1 1 3 1 0 0.820 1.000 1.000 590 KREBPATHWAY The Krebs (citric acid) cycle takes place in mitochondria, where it extracts energy in the form of electron carriers NADH and FADH2, which drive the electron transport chain. ACO2, CS, FH, IDH2, MDH1, OGDH, SDHA, SUCLA2 8 ACO2(5), CS(2), FH(3), IDH2(1), MDH1(3), OGDH(8), SDHA(3) 3874920 25 23 25 22 16 0 2 4 3 0 0.962 1.000 1.000 591 RNAPATHWAY dsRNA-activated protein kinase phosphorylates elF2a, which generally inhibits translation, and activates NF-kB to provoke inflammation. CHUK, DNAJC3, EIF2S1, EIF2S2, MAP3K14, NFKB1, NFKBIA, PRKR, RELA, TP53 8 CHUK(2), DNAJC3(3), EIF2S1(1), MAP3K14(6), NFKB1(6), NFKBIA(2), RELA(4) 3618827 24 23 24 13 14 4 1 3 2 0 0.674 1.000 1.000 592 UBIQUINONE_BIOSYNTHESIS NDUFA1, NDUFA10, NDUFA11, NDUFA4, NDUFA5, NDUFA8, NDUFB2, NDUFB4, NDUFB5, NDUFB6, NDUFB7, NDUFS1, NDUFS2, NDUFV1, NDUFV2 15 NDUFA10(4), NDUFA4(1), NDUFB2(2), NDUFB5(3), NDUFB6(2), NDUFB7(2), NDUFS1(2), NDUFS2(3), NDUFV1(3), NDUFV2(1) 2860008 23 23 23 10 16 1 0 5 1 0 0.578 1.000 1.000 593 HEME_BIOSYNTHESIS ALAD, ALAS1, ALAS2, CPOX, FECH, HMBS, PPOX, UROD, UROS 9 ALAD(5), ALAS1(2), ALAS2(5), CPOX(4), FECH(3), HMBS(1), PPOX(4), UROS(1) 3092599 25 22 25 11 16 2 1 3 3 0 0.350 1.000 1.000 594 PROTEASOME PSMA1, PSMA2, PSMA3, PSMA4, PSMA5, PSMA6, PSMA7, PSMB1, PSMB10, PSMB2, PSMB3, PSMB4, PSMB5, PSMB6, PSMB7, PSMB8, PSMB9 17 PSMA1(4), PSMA4(2), PSMA5(3), PSMA6(4), PSMB1(1), PSMB10(2), PSMB2(1), PSMB4(1), PSMB5(1), PSMB6(1), PSMB7(2), PSMB8(4) 3599729 26 22 26 10 16 1 2 5 2 0 0.369 1.000 1.000 595 SALMONELLAPATHWAY Salmonella induces membrane ruffling in infected cells via bacterial proteins including SipA, SipC, and SopE, which alter actin structure. ACTA1, ACTR2, ACTR3, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, CDC42, RAC1, WASF1, WASL 11 ACTA1(4), ACTR2(3), ACTR3(2), ARPC1B(3), ARPC2(1), ARPC3(1), CDC42(2), WASF1(4), WASL(5) 3152868 25 22 25 10 16 2 1 4 2 0 0.387 1.000 1.000 596 TCAPOPTOSISPATHWAY HIV infection upregulates Fas ligand in macrophages and CD4 in helper T cells, leading to widespread Fas-induced T cell apoptosis. CCR5, CD28, CD3D, CD3E, CD3G, CD3Z, CD4, TNFRSF6, TNFSF6, TRA@, TRB@ 6 CCR5(10), CD28(2), CD3D(7), CD3E(2), CD3G(1), CD4(8) 1310216 30 22 29 22 21 3 0 3 3 0 0.619 1.000 1.000 597 BENZOATE_DEGRADATION_VIA_COA_LIGATION ACAT1, ACAT2, ACYP1, ACYP2, ECHS1, EHHADH, GCDH, HADHA, SDHB, SDS 10 ACAT2(1), ACYP1(1), ECHS1(3), EHHADH(6), GCDH(6), HADHA(6), SDS(2) 3191187 25 21 24 11 16 4 0 3 2 0 0.364 1.000 1.000 598 GANGLIOSIDE_BIOSYNTHESIS B3GALT4, GALGT, SIAT4A, SIAT4B, SIAT7B, SIAT7D, SIAT9, ST3GAL1, ST3GAL2, ST3GAL4, ST3GAL5, ST6GALNAC2, ST6GALNAC4, ST8SIA1 8 B3GALT4(2), ST3GAL1(7), ST3GAL2(1), ST3GAL4(2), ST3GAL5(2), ST6GALNAC2(2), ST6GALNAC4(4), ST8SIA1(1) 2319843 21 21 21 12 13 2 1 4 1 0 0.518 1.000 1.000 599 HSA00625_TETRACHLOROETHENE_DEGRADATION Genes involved in tetrachloroethene degradation AKR1B10, EPHX2, HSD3B7, RDH11, RDH12, RDH13, RDH14 7 AKR1B10(9), EPHX2(5), HSD3B7(5), RDH11(1), RDH12(2), RDH13(3) 1969976 25 21 25 18 18 2 2 0 3 0 0.641 1.000 1.000 600 NOTCHPATHWAY Proteolysis and Signaling Pathway of Notch ADAM17, DLL1, FURIN, NOTCH1, PSEN1, RBPSUH 5 ADAM17(1), DLL1(2), FURIN(10), NOTCH1(9), PSEN1(1) 3757261 23 21 23 21 11 4 2 6 0 0 0.950 1.000 1.000 601 HSA00791_ATRAZINE_DEGRADATION Genes involved in atrazine degradation ADAR, APOBEC1, APOBEC2, APOBEC3A, APOBEC3B, APOBEC3C, APOBEC3F, APOBEC3G, APOBEC4 9 ADAR(6), APOBEC1(3), APOBEC2(5), APOBEC3B(4), APOBEC3C(2), APOBEC3F(3) 3021240 23 19 23 28 17 2 2 2 0 0 0.998 1.000 1.000 602 REDUCTIVE_CARBOXYLATE_CYCLE_CO2_FIXATION ACO1, ACO2, FH, IDH1, IDH2, MDH1, MDH2, SDHB, SUCLA2 8 ACO1(6), ACO2(5), FH(3), IDH2(1), MDH1(3), MDH2(3) 3319994 21 19 20 17 14 0 1 2 4 0 0.895 1.000 1.000 603 CAPROLACTAM_DEGRADATION AKR1A1, ECHS1, EHHADH, HADHA, SDS 5 AKR1A1(3), ECHS1(3), EHHADH(6), HADHA(6), SDS(2) 1978955 20 18 18 10 13 3 0 2 2 0 0.438 1.000 1.000 604 METHIONINEPATHWAY Catabolic Pathways for Methionine, Isoleucine, Threonine and Valine BCKDHB, BCKDK, CBS, CTH, MUT 5 BCKDHB(2), BCKDK(2), CBS(7), CTH(1), MUT(6) 2070249 18 18 18 10 11 2 1 3 1 0 0.669 1.000 1.000 605 LYSINE_BIOSYNTHESIS AADAT, AASDH, AASDHPPT, AASS, KARS 5 AADAT(5), AASDH(5), AASDHPPT(3), AASS(3), KARS(3) 2828028 19 17 19 8 17 0 0 1 1 0 0.526 1.000 1.000 606 SA_BONE_MORPHOGENETIC Bone morphogenetic protein binds to its receptor to induce ectopic bone formation and promote development of the viscera. BMP1, BMPR1A, BMPR1B, BMPR2, MADH1, MADH4, MADH6 4 BMP1(5), BMPR1A(2), BMPR1B(4), BMPR2(6) 2570954 17 17 17 10 10 2 1 2 2 0 0.730 1.000 1.000 607 HSA00643_STYRENE_DEGRADATION Genes involved in styrene degradation FAH, GSTZ1, HGD 3 FAH(4), GSTZ1(1), HGD(13) 916767 18 16 18 17 12 2 2 0 2 0 0.922 1.000 1.000 608 ARGININECPATHWAY Related catabolic pathways process arginine, histidine, glutamine, and proline through glutamate to alpha-ketoglutamate, which feeds into the citric acid cycle. ALDH4A1, ARG1, GLS, GLUD1, OAT, PRODH 6 ALDH4A1(6), ARG1(2), GLS(2), GLUD1(2), OAT(4), PRODH(2) 2223393 18 14 18 14 6 4 3 3 2 0 0.939 1.000 1.000 609 BLOOD_GROUP_GLYCOLIPID_BIOSYNTHESIS_NEOLACTOSERIES ABO, B3GNT1, FUT1, FUT2, FUT9, GCNT2, ST8SIA1 6 ABO(5), B3GNT1(3), FUT1(3), FUT2(3), ST8SIA1(1) 2175763 15 14 15 14 12 1 1 1 0 0 0.831 1.000 1.000 610 HSA00550_PEPTIDOGLYCAN_BIOSYNTHESIS Genes involved in peptidoglycan biosynthesis GLUL, PGLYRP2 2 GLUL(2), PGLYRP2(20) 747811 22 14 21 13 15 2 1 3 1 0 0.608 1.000 1.000 611 HSA00520_NUCLEOTIDE_SUGARS_METABOLISM Genes involved in nucleotide sugars metabolism GALE, GALT, TGDS, UGDH, UGP2, UXS1 6 GALT(2), TGDS(1), UGDH(1), UGP2(1), UXS1(4) 2010636 9 9 9 11 3 0 1 0 5 0 0.993 1.000 1.000 612 HSA00900_TERPENOID_BIOSYNTHESIS Genes involved in terpenoid biosynthesis FDFT1, FDPS, GGPS1, IDI1, IDI2, SQLE 6 FDPS(3), GGPS1(1), IDI1(1), IDI2(1), SQLE(3) 1734510 9 9 9 7 6 1 1 1 0 0 0.820 1.000 1.000 613 HSA00780_BIOTIN_METABOLISM Genes involved in biotin metabolism BTD, HLCS, SPCS1, SPCS3 4 BTD(2), HLCS(6) 1265112 8 8 8 10 6 0 1 1 0 0 0.967 1.000 1.000 614 NUCLEOTIDE_SUGARS_METABOLISM GALE, GALT, TGDS, UGDH, UXS1 5 GALT(2), TGDS(1), UGDH(1), UXS1(4) 1576102 8 8 8 10 2 0 1 0 5 0 0.992 1.000 1.000 615 TERPENOID_BIOSYNTHESIS FDFT1, FDPS, FDPS, LOC402397, IDI1, SQLE 4 FDPS(3), IDI1(1), SQLE(3) 1295017 7 7 7 5 4 1 1 1 0 0 0.777 1.000 1.000 616 HSA00660_C5_BRANCHED_DIBASIC_ACID_METABOLISM Genes involved in C5-branched dibasic acid metabolism ILVBL, SUCLA2 2 ILVBL(5) 870689 5 5 5 5 5 0 0 0 0 0 0.859 1.000 1.000