E-cadherin signaling in the nascent adherens junction Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations CTTN -0.091 0.219 -9999.0 0.0 -0.445 101.0 101.0 KLHL20 -0.003 0.089 -9999.0 0.0 -0.221 7.0 7.0 CYFIP2 -0.01 0.123 -9999.0 0.0 -0.536 19.0 19.0 Rac1/GDP -0.022 0.142 -9999.0 0.0 -0.25 99.0 99.0 ENAH -0.091 0.22 -9999.0 0.0 -0.445 101.0 101.0 AP1M1 0.019 0.0 -9999.0 0.0 -9999.0 0.0 0.0 RAP1B 0.019 0.0 -9999.0 0.0 -9999.0 0.0 0.0 RAP1A 0.019 0.0 -9999.0 0.0 -9999.0 0.0 0.0 CTNNB1 0.019 0.0 -9999.0 0.0 -9999.0 0.0 0.0 CDC42/GTP -0.048 0.079 -9999.0 0.0 -0.24 7.0 7.0 ABI1/Sra1/Nap1 -0.032 0.046 -9999.0 0.0 -0.169 15.0 15.0 E-cadherin/beta catenin/alpha catenin/beta7/alphaE Integrin -0.088 0.191 -9999.0 0.0 -0.325 134.0 134.0 RAPGEF1 -0.064 0.193 -9999.0 0.0 -0.377 101.0 101.0 CTNND1 0.019 0.0 -9999.0 0.0 -9999.0 0.0 0.0 regulation of calcium-dependent cell-cell adhesion -0.099 0.226 -9999.0 0.0 -0.464 101.0 101.0 CRK -0.078 0.207 -9999.0 0.0 -0.413 101.0 101.0 E-cadherin/gamma catenin/alpha catenin -0.064 0.161 -9999.0 0.0 -0.321 101.0 101.0 alphaE/beta7 Integrin -0.032 0.145 -9999.0 0.0 -0.382 54.0 54.0 IQGAP1 0.019 0.0 -9999.0 0.0 -9999.0 0.0 0.0 NCKAP1 0.019 0.0 -9999.0 0.0 -9999.0 0.0 0.0 Rap1/GTP/I-afadin 0.027 0.036 -9999.0 0.0 -9999.0 0.0 0.0 DLG1 -0.09 0.22 -9999.0 0.0 -0.445 101.0 101.0 ChemicalAbstracts:7440-70-2 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 mol:PI-3-4-5-P3 -0.035 0.057 -9999.0 0.0 -0.173 8.0 8.0 MLLT4 0.0 0.067 -9999.0 0.0 -0.243 26.0 26.0 ARF6/GTP/NME1/Tiam1 0.017 0.077 -9999.0 0.0 -0.287 22.0 22.0 PI3K -0.044 0.072 -9999.0 0.0 -0.221 8.0 8.0 ARF6 0.019 0.0 -9999.0 0.0 -9999.0 0.0 0.0 mol:Ca2+ 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/gamma catenin -0.09 0.186 -9999.0 0.0 -0.387 101.0 101.0 TIAM1 -0.015 0.132 -9999.0 0.0 -0.536 22.0 22.0 E-cadherin(dimer)/Ca2+ -0.04 0.138 -9999.0 0.0 -0.263 101.0 101.0 AKT1 -0.025 0.042 -9999.0 0.0 -9999.0 0.0 0.0 PIK3R1 0.019 0.0 -9999.0 0.0 -9999.0 0.0 0.0 CDH1 -0.134 0.248 -9999.0 0.0 -0.536 101.0 101.0 RhoA/GDP -0.022 0.142 -9999.0 0.0 -0.251 99.0 99.0 actin cytoskeleton organization 0.0 0.068 -9999.0 0.0 -0.161 7.0 7.0 CDC42/GDP -0.022 0.142 -9999.0 0.0 -0.251 99.0 99.0 E-cadherin/Ca2+/gamma catenin/alpha catenin/p120 catenin -0.048 0.123 -9999.0 0.0 -0.246 101.0 101.0 ITGB7 -0.063 0.197 -9999.0 0.0 -0.536 54.0 54.0 RAC1 0.019 0.0 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/beta catenin/alpha catenin/p120 catenin -0.042 0.147 -9999.0 0.0 -0.28 101.0 101.0 E-cadherin/Ca2+/beta catenin/alpha catenin -0.05 0.136 -9999.0 0.0 -0.27 101.0 101.0 mol:GDP -0.038 0.159 -9999.0 0.0 -0.294 101.0 101.0 CDC42/GTP/IQGAP1 0.026 0.0 -9999.0 0.0 -9999.0 0.0 0.0 JUP 0.011 0.045 -9999.0 0.0 -0.243 11.0 11.0 p120 catenin/RhoA/GDP -0.022 0.143 -9999.0 0.0 -0.301 10.0 10.0 RAC1/GTP/IQGAP1 0.026 0.0 -9999.0 0.0 -9999.0 0.0 0.0 PIP5K1C/AP1M1 0.028 0.0 -9999.0 0.0 -9999.0 0.0 0.0 RHOA 0.019 0.0 -9999.0 0.0 -9999.0 0.0 0.0 CDC42 0.019 0.0 -9999.0 0.0 -9999.0 0.0 0.0 CTNNA1 0.019 0.0 -9999.0 0.0 -9999.0 0.0 0.0 positive regulation of S phase of mitotic cell cycle 0.003 0.051 -9999.0 0.0 -0.135 4.0 4.0 NME1 0.019 0.0 -9999.0 0.0 -9999.0 0.0 0.0 clathrin coat assembly 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 TJP1 -0.09 0.22 -9999.0 0.0 -0.445 101.0 101.0 regulation of cell-cell adhesion -0.043 0.071 -9999.0 0.0 -0.212 7.0 7.0 WASF2 -0.016 0.025 -9999.0 0.0 -0.114 2.0 2.0 Rap1/GTP -0.016 0.116 -9999.0 0.0 -0.274 7.0 7.0 E-cadherin/gamma catenin/alpha catenin/beta7/alphaE Integrin -0.078 0.184 -9999.0 0.0 -0.304 134.0 134.0 CCND1 0.003 0.06 -9999.0 0.0 -0.164 4.0 4.0 VAV2 -0.073 0.215 -9999.0 0.0 -0.548 12.0 12.0 RAP1/GDP -0.019 0.124 -9999.0 0.0 -0.274 9.0 9.0 adherens junction assembly -0.086 0.213 -9999.0 0.0 -0.431 101.0 101.0 homophilic cell adhesion 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ABI1 0.019 0.0 -9999.0 0.0 -9999.0 0.0 0.0 PIP5K1C 0.019 0.0 -9999.0 0.0 -9999.0 0.0 0.0 regulation of heterotypic cell-cell adhesion -0.069 0.176 -9999.0 0.0 -0.285 134.0 134.0 E-cadherin/beta catenin -0.086 0.17 -9999.0 0.0 -0.362 101.0 101.0 mol:GTP 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 SRC -0.09 0.22 -9999.0 0.0 -0.445 101.0 101.0 PIK3CA 0.018 0.014 -9999.0 0.0 -0.243 1.0 1.0 Rac1/GTP -0.066 0.095 -9999.0 0.0 -0.35 8.0 8.0 E-cadherin/beta catenin/alpha catenin -0.059 0.159 -9999.0 0.0 -0.316 101.0 101.0 ITGAE 0.019 0.0 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin -0.102 0.231 -9999.0 0.0 -0.474 101.0 101.0