Signaling events mediated by the Hedgehog family Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations TGFB2 0.028 0.119 -9999.0 0.0 -0.49 12.0 12.0 IHH 0.015 0.048 -9999.0 0.0 -0.229 9.0 9.0 SHH Np/Cholesterol/GAS1 0.017 0.034 -9999.0 0.0 -0.295 4.0 4.0 LRPAP1 0.019 0.0 -9999.0 0.0 -9999.0 0.0 0.0 dorsoventral neural tube patterning -0.017 0.034 0.293 4.0 -9999.0 0.0 4.0 SMO/beta Arrestin2 0.04 0.092 -9999.0 0.0 -0.496 4.0 4.0 SMO 0.032 0.096 -9999.0 0.0 -0.527 4.0 4.0 AKT1 0.044 0.048 -9999.0 0.0 -9999.0 0.0 0.0 ARRB2 0.019 0.0 -9999.0 0.0 -9999.0 0.0 0.0 BOC 0.015 0.03 -9999.0 0.0 -0.243 5.0 5.0 ADRBK1 0.019 0.0 -9999.0 0.0 -9999.0 0.0 0.0 heart looping 0.032 0.095 -9999.0 0.0 -0.519 4.0 4.0 STIL 0.035 0.064 -9999.0 0.0 -0.393 3.0 3.0 DHH N/PTCH2 0.002 0.084 -9999.0 0.0 -0.382 12.0 12.0 DHH N/PTCH1 0.02 0.099 -9999.0 0.0 -0.325 15.0 15.0 PIK3CA 0.018 0.014 -9999.0 0.0 -0.243 1.0 1.0 DHH -0.011 0.108 -9999.0 0.0 -0.355 29.0 29.0 PTHLH 0.022 0.157 -9999.0 0.0 -0.699 12.0 12.0 determination of left/right symmetry 0.032 0.095 -9999.0 0.0 -0.519 4.0 4.0 PIK3R1 0.019 0.0 -9999.0 0.0 -9999.0 0.0 0.0 skeletal system development 0.022 0.156 -9999.0 0.0 -0.691 12.0 12.0 IHH N/Hhip 0.012 0.026 -9999.0 0.0 -9999.0 0.0 0.0 DHH N/Hhip -0.007 0.077 -9999.0 0.0 -0.391 11.0 11.0 mol:Cholesterol -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 heart development 0.032 0.095 -9999.0 0.0 -0.519 4.0 4.0 pancreas development 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 HHAT 0.017 0.032 -9999.0 0.0 -0.39 2.0 2.0 PI3K 0.028 0.009 -9999.0 0.0 -9999.0 0.0 0.0 EntrezGene:84976 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 GAS1 0.014 0.052 -9999.0 0.0 -0.463 4.0 4.0 somite specification 0.032 0.095 -9999.0 0.0 -0.519 4.0 4.0 SHH Np/Cholesterol/PTCH1 0.031 0.068 -9999.0 0.0 -0.419 3.0 3.0 SHH Np/Cholesterol/PTCH2 0.017 0.03 -9999.0 0.0 -0.294 2.0 2.0 SHH Np/Cholesterol/Megalin -0.148 0.159 -9999.0 0.0 -0.297 194.0 194.0 SHH 0.011 0.023 -9999.0 0.0 -0.391 1.0 1.0 catabolic process 0.03 0.083 -9999.0 0.0 -0.364 8.0 8.0 SMO/Vitamin D3 0.036 0.08 -9999.0 0.0 -0.519 3.0 3.0 SHH Np/Cholesterol/Hhip 0.008 0.017 -9999.0 0.0 -0.301 1.0 1.0 LRP2 -0.276 0.276 -9999.0 0.0 -0.536 194.0 194.0 receptor-mediated endocytosis -0.083 0.148 -9999.0 0.0 -0.475 12.0 12.0 SHH Np/Cholesterol/BOC 0.019 0.023 -9999.0 0.0 -0.294 1.0 1.0 SHH Np/Cholesterol/CDO 0.02 0.018 -9999.0 0.0 -0.294 1.0 1.0 mesenchymal cell differentiation -0.007 0.017 0.299 1.0 -9999.0 0.0 1.0 mol:Vitamin D3 0.035 0.069 -9999.0 0.0 -0.42 3.0 3.0 IHH N/PTCH2 0.021 0.045 -9999.0 0.0 -0.272 3.0 3.0 CDON 0.019 0.0 -9999.0 0.0 -9999.0 0.0 0.0 IHH N/PTCH1 0.033 0.084 -9999.0 0.0 -0.366 8.0 8.0 Megalin/LRPAP1 -0.19 0.204 -9999.0 0.0 -0.382 194.0 194.0 PTCH2 0.012 0.046 -9999.0 0.0 -0.28 8.0 8.0 SHH Np/Cholesterol 0.011 0.018 -9999.0 0.0 -0.302 1.0 1.0 PTCH1 0.03 0.083 -9999.0 0.0 -0.365 8.0 8.0 HHIP -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0