Pathway Name	Avg Num Perturbations	Total Perturbations	Num Entities	Min Mean Truth	Max Mean Truth	Min Mean Within	Max Mean Within	Min Mean Any	Max Mean Within
IL4-mediated signaling events	139.0	12732.0	91.0	-1.306	1.04	1000.0	-1000.0	-0.1	-1000.0
BCR signaling pathway	136.0	13536.0	99.0	-0.763	0.026	1000.0	-1000.0	-0.057	-1000.0
TCR signaling in naïve CD8+ T cells	103.0	9621.0	93.0	-0.59	0.028	1000.0	-1000.0	-0.047	-1000.0
IL23-mediated signaling events	102.0	6177.0	60.0	-0.736	0.019	1000.0	-1000.0	-0.051	-1000.0
Nephrin/Neph1 signaling in the kidney podocyte	91.0	3110.0	34.0	-0.211	0.019	1000.0	-1000.0	-0.013	-1000.0
IL12-mediated signaling events	80.0	7003.0	87.0	-0.681	0.114	1000.0	-1000.0	-0.091	-1000.0
Caspase cascade in apoptosis	65.0	4881.0	74.0	-0.208	0.136	1000.0	-1000.0	-0.026	-1000.0
FAS signaling pathway (CD95)	65.0	3095.0	47.0	-0.163	0.12	1000.0	-1000.0	-0.012	-1000.0
Calcineurin-regulated NFAT-dependent transcription in lymphocytes	63.0	4308.0	68.0	-0.623	0.12	1000.0	-1000.0	-0.044	-1000.0
E-cadherin signaling events	62.0	314.0	5.0	-0.134	0.019	1000.0	-1000.0	-0.005	-1000.0
Calcium signaling in the CD4+ TCR pathway	58.0	1807.0	31.0	-0.431	0.019	1000.0	-1000.0	-0.038	-1000.0
JNK signaling in the CD4+ TCR pathway	56.0	959.0	17.0	-0.203	0.019	1000.0	-1000.0	-0.015	-1000.0
Ras signaling in the CD4+ TCR pathway	56.0	952.0	17.0	-0.166	0.037	1000.0	-1000.0	-0.011	-1000.0
IL27-mediated signaling events	53.0	2704.0	51.0	-0.266	0.165	1000.0	-1000.0	-0.037	-1000.0
S1P4 pathway	53.0	1330.0	25.0	-0.165	0.028	1000.0	-1000.0	-0.008	-1000.0
Glypican 1 network	50.0	2429.0	48.0	-0.299	0.068	1000.0	-1000.0	-0.017	-1000.0
Signaling events regulated by Ret tyrosine kinase	49.0	4078.0	82.0	-0.129	0.019	1000.0	-1000.0	-0.053	-1000.0
Wnt signaling	48.0	341.0	7.0	-0.082	0.008	1000.0	-1000.0	-0.011	-1000.0
amb2 Integrin signaling	46.0	3806.0	82.0	-0.27	0.026	1000.0	-1000.0	-0.025	-1000.0
Stabilization and expansion of the E-cadherin adherens junction	46.0	3466.0	74.0	-0.134	0.05	1000.0	-1000.0	-0.05	-1000.0
a4b1 and a4b7 Integrin signaling	44.0	222.0	5.0	-0.076	-0.019	1000.0	-1000.0	-0.002	-1000.0
Glucocorticoid receptor regulatory network	42.0	4892.0	114.0	-0.516	0.309	1000.0	-1000.0	-0.041	-1000.0
Thromboxane A2 receptor signaling	41.0	4340.0	105.0	-0.123	0.041	1000.0	-1000.0	-0.039	-1000.0
Endothelins	41.0	3951.0	96.0	-0.178	0.02	1000.0	-1000.0	-0.04	-1000.0
HIV-1 Nef: Negative effector of Fas and TNF-alpha	41.0	1855.0	45.0	-0.276	0.046	1000.0	-1000.0	-0.051	-1000.0
TCGA08_retinoblastoma	41.0	331.0	8.0	-0.106	0.03	1000.0	-1000.0	-0.005	-1000.0
E-cadherin signaling in the nascent adherens junction	40.0	3043.0	76.0	-0.134	0.028	1000.0	-1000.0	-0.055	-1000.0
Syndecan-4-mediated signaling events	40.0	2681.0	67.0	-0.256	0.025	1000.0	-1000.0	-0.021	-1000.0
Angiopoietin receptor Tie2-mediated signaling	39.0	3471.0	88.0	-0.226	0.03	1000.0	-1000.0	-0.056	-1000.0
IL2 signaling events mediated by PI3K	38.0	2241.0	58.0	-0.192	0.046	1000.0	-1000.0	-0.021	-1000.0
IL2 signaling events mediated by STAT5	38.0	839.0	22.0	-0.194	0.02	1000.0	-1000.0	-0.022	-1000.0
Paxillin-independent events mediated by a4b1 and a4b7	37.0	1387.0	37.0	-0.292	0.041	1000.0	-1000.0	-0.015	-1000.0
Regulation of p38-alpha and p38-beta	37.0	2012.0	54.0	-0.339	0.049	1000.0	-1000.0	-0.034	-1000.0
LPA receptor mediated events	35.0	3659.0	102.0	-0.132	0.025	1000.0	-1000.0	-0.051	-1000.0
Class I PI3K signaling events	34.0	2506.0	73.0	-0.449	0.048	1000.0	-1000.0	-0.023	-1000.0
Fc-epsilon receptor I signaling in mast cells	32.0	3137.0	97.0	-0.134	0.033	1000.0	-1000.0	-0.05	-1000.0
HIF-1-alpha transcription factor network	31.0	2401.0	76.0	-0.115	0.084	1000.0	-1000.0	-0.045	-1000.0
Ephrin A  reverse signaling	30.0	213.0	7.0	-0.071	0.008	1000.0	-1000.0	-0.004	-1000.0
Atypical NF-kappaB pathway	29.0	900.0	31.0	-0.195	0.033	1000.0	-1000.0	-0.007	-1000.0
Syndecan-1-mediated signaling events	28.0	961.0	34.0	-0.148	0.019	1000.0	-1000.0	-0.018	-1000.0
Visual signal transduction: Cones	28.0	1087.0	38.0	-0.209	0.017	1000.0	-1000.0	-0.007	-1000.0
ceramide signaling pathway	28.0	1394.0	49.0	-0.175	0.028	1000.0	-1000.0	-0.013	-1000.0
Visual signal transduction: Rods	28.0	1463.0	52.0	-0.209	0.019	1000.0	-1000.0	-0.039	-1000.0
TRAIL signaling pathway	27.0	1303.0	48.0	-0.057	0.021	1000.0	-1000.0	-0.022	-1000.0
FOXA2 and FOXA3 transcription factor networks	25.0	1176.0	46.0	-0.499	0.027	1000.0	-1000.0	-0.029	-1000.0
TCGA08_p53	25.0	177.0	7.0	-0.071	0.051	1000.0	-1000.0	-0.005	-1000.0
Noncanonical Wnt signaling pathway	24.0	645.0	26.0	-0.082	0.019	1000.0	-1000.0	-0.019	-1000.0
BMP receptor signaling	24.0	1969.0	81.0	-0.229	0.059	1000.0	-1000.0	-0.059	-1000.0
Sphingosine 1-phosphate (S1P) pathway	23.0	660.0	28.0	-0.165	0.049	1000.0	-1000.0	-0.01	-1000.0
RXR and RAR heterodimerization with other nuclear receptor	23.0	1226.0	52.0	-0.192	0.031	1000.0	-1000.0	-0.02	-1000.0
Aurora C signaling	22.0	156.0	7.0	-0.098	0.017	1000.0	-1000.0	-0.01	-1000.0
IL6-mediated signaling events	22.0	1701.0	75.0	-0.188	0.068	1000.0	-1000.0	-0.02	-1000.0
Arf6 signaling events	20.0	1259.0	62.0	-0.175	0.045	1000.0	-1000.0	-0.016	-1000.0
Signaling events mediated by PTP1B	20.0	1554.0	76.0	-0.339	0.032	1000.0	-1000.0	-0.032	-1000.0
IFN-gamma pathway	20.0	1411.0	68.0	-0.177	0.028	1000.0	-1000.0	-0.056	-1000.0
Paxillin-dependent events mediated by a4b1	20.0	734.0	36.0	-0.077	0.059	1000.0	-1000.0	-0.026	-1000.0
Osteopontin-mediated events	19.0	756.0	38.0	-0.049	0.035	1000.0	-1000.0	-0.026	-1000.0
Syndecan-2-mediated signaling events	19.0	1333.0	69.0	-0.256	0.046	1000.0	-1000.0	-0.019	-1000.0
p75(NTR)-mediated signaling	19.0	2417.0	125.0	-0.175	0.054	1000.0	-1000.0	-0.051	-1000.0
Integrins in angiogenesis	19.0	1656.0	84.0	-0.2	0.043	1000.0	-1000.0	-0.053	-1000.0
Effects of Botulinum toxin	17.0	445.0	26.0	-0.066	0.026	1000.0	-1000.0	-0.015	-1000.0
Signaling events mediated by Stem cell factor receptor (c-Kit)	17.0	1361.0	78.0	-0.147	0.056	1000.0	-1000.0	-0.023	-1000.0
EPO signaling pathway	16.0	898.0	55.0	-0.079	0.029	1000.0	-1000.0	-0.047	-1000.0
EPHB forward signaling	16.0	1440.0	85.0	-0.059	0.041	1000.0	-1000.0	-0.048	-1000.0
EGFR-dependent Endothelin signaling events	16.0	348.0	21.0	-0.031	0.028	1000.0	-1000.0	-0.039	-1000.0
Signaling events mediated by the Hedgehog family	15.0	805.0	52.0	-0.276	0.044	1000.0	-1000.0	-0.015	-1000.0
Cellular roles of Anthrax toxin	15.0	611.0	39.0	-0.148	0.019	1000.0	-1000.0	-0.008	-1000.0
Nectin adhesion pathway	15.0	951.0	63.0	-0.244	0.045	1000.0	-1000.0	-0.043	-1000.0
Ceramide signaling pathway	15.0	1169.0	76.0	-0.175	0.042	1000.0	-1000.0	-0.012	-1000.0
E-cadherin signaling in keratinocytes	15.0	665.0	43.0	-0.134	0.022	1000.0	-1000.0	-0.02	-1000.0
S1P5 pathway	14.0	254.0	17.0	-0.094	0.019	1000.0	-1000.0	-0.005	-1000.0
Plasma membrane estrogen receptor signaling	14.0	1273.0	86.0	-0.094	0.048	1000.0	-1000.0	-0.048	-1000.0
Coregulation of Androgen receptor activity	13.0	1048.0	76.0	-0.107	0.038	1000.0	-1000.0	-0.021	-1000.0
Signaling events activated by Hepatocyte Growth Factor Receptor (c-Met)	13.0	1111.0	85.0	-0.075	0.041	1000.0	-1000.0	-0.05	-1000.0
Ephrin B reverse signaling	13.0	658.0	48.0	-0.119	0.021	1000.0	-1000.0	-0.029	-1000.0
Role of Calcineurin-dependent NFAT signaling in lymphocytes	13.0	1111.0	83.0	-0.157	0.085	1000.0	-1000.0	-0.02	-1000.0
Nongenotropic Androgen signaling	13.0	694.0	52.0	-0.094	0.037	1000.0	-1000.0	-0.025	-1000.0
Neurotrophic factor-mediated Trk receptor signaling	13.0	1643.0	120.0	-0.115	0.078	1000.0	-1000.0	-0.043	-1000.0
LPA4-mediated signaling events	12.0	155.0	12.0	-0.056	0.02	1000.0	-1000.0	-0.007	-1000.0
Reelin signaling pathway	12.0	704.0	56.0	-0.105	0.052	1000.0	-1000.0	-0.048	-1000.0
IL1-mediated signaling events	12.0	744.0	62.0	-0.069	0.07	1000.0	-1000.0	-0.049	-1000.0
Syndecan-3-mediated signaling events	11.0	410.0	35.0	-0.054	0.054	1000.0	-1000.0	-0.02	-1000.0
Glypican 2 network	11.0	47.0	4.0	0.004	0.01	1000.0	-1000.0	-0.006	-1000.0
S1P3 pathway	11.0	488.0	42.0	-0.092	0.037	1000.0	-1000.0	-0.017	-1000.0
ErbB2/ErbB3 signaling events	10.0	713.0	65.0	-0.023	0.042	1000.0	-1000.0	-0.041	-1000.0
Presenilin action in Notch and Wnt signaling	10.0	617.0	61.0	-0.11	0.055	1000.0	-1000.0	-0.029	-1000.0
S1P1 pathway	10.0	364.0	36.0	-0.094	0.021	1000.0	-1000.0	-0.038	-1000.0
Canonical Wnt signaling pathway	10.0	519.0	51.0	-0.078	0.071	1000.0	-1000.0	-0.026	-1000.0
ErbB4 signaling events	9.0	683.0	69.0	-0.122	0.052	1000.0	-1000.0	-0.049	-1000.0
Lissencephaly gene (LIS1) in neuronal migration and development	9.0	496.0	54.0	-0.127	0.033	1000.0	-1000.0	-0.056	-1000.0
Regulation of Androgen receptor activity	9.0	681.0	70.0	-0.139	0.056	1000.0	-1000.0	-0.026	-1000.0
Hypoxic and oxygen homeostasis regulation of HIF-1-alpha	8.0	266.0	33.0	-0.107	0.055	1000.0	-1000.0	-0.017	-1000.0
Rapid glucocorticoid signaling	8.0	170.0	20.0	-0.02	0.02	1000.0	-1000.0	-0.004	-1000.0
PDGFR-beta signaling pathway	8.0	861.0	97.0	-0.341	0.061	1000.0	-1000.0	-0.05	-1000.0
Regulation of nuclear SMAD2/3 signaling	7.0	1021.0	136.0	-0.108	0.082	1000.0	-1000.0	-0.026	-1000.0
Signaling events mediated by HDAC Class I	6.0	669.0	104.0	-0.095	0.063	1000.0	-1000.0	-0.026	-1000.0
Signaling mediated by p38-gamma and p38-delta	6.0	104.0	15.0	-0.03	0.027	1000.0	-1000.0	-0.012	-1000.0
Signaling mediated by p38-alpha and p38-beta	6.0	301.0	44.0	-0.038	0.028	1000.0	-1000.0	-0.007	-1000.0
Regulation of Telomerase	6.0	706.0	102.0	-0.171	0.069	1000.0	-1000.0	-0.053	-1000.0
Insulin Pathway	6.0	459.0	74.0	-0.061	0.048	1000.0	-1000.0	-0.051	-1000.0
Signaling events mediated by PRL	6.0	206.0	34.0	-0.089	0.049	1000.0	-1000.0	-0.016	-1000.0
Class IB PI3K non-lipid kinase events	6.0	18.0	3.0	-0.01	0.01	1000.0	-1000.0	-0.003	-1000.0
Aurora B signaling	6.0	445.0	67.0	-0.147	0.057	1000.0	-1000.0	-0.029	-1000.0
Canonical NF-kappaB pathway	5.0	232.0	39.0	-0.095	0.085	1000.0	-1000.0	-0.049	-1000.0
Hedgehog signaling events mediated by Gli proteins	5.0	388.0	65.0	-0.093	0.085	1000.0	-1000.0	-0.044	-1000.0
TCGA08_rtk_signaling	5.0	145.0	26.0	-0.056	0.05	1000.0	-1000.0	-0.007	-1000.0
FOXM1 transcription factor network	5.0	270.0	51.0	-0.114	0.287	1000.0	-1000.0	-0.11	-1000.0
PDGFR-alpha signaling pathway	4.0	202.0	44.0	-0.013	0.041	1000.0	-1000.0	-0.012	-1000.0
Signaling events mediated by HDAC Class III	4.0	199.0	40.0	-0.094	0.035	1000.0	-1000.0	-0.012	-1000.0
Insulin-mediated glucose transport	3.0	117.0	32.0	-0.034	0.049	1000.0	-1000.0	-0.019	-1000.0
FoxO family signaling	3.0	201.0	64.0	-0.431	0.175	1000.0	-1000.0	-0.032	-1000.0
Retinoic acid receptors-mediated signaling	3.0	225.0	58.0	-0.05	0.057	1000.0	-1000.0	-0.039	-1000.0
Signaling events mediated by VEGFR1 and VEGFR2	3.0	415.0	125.0	-0.121	0.082	1000.0	-1000.0	-0.059	-1000.0
p38 MAPK signaling pathway	3.0	152.0	44.0	-0.046	0.042	1000.0	-1000.0	-0.043	-1000.0
Signaling events mediated by HDAC Class II	2.0	182.0	75.0	-0.063	0.054	1000.0	-1000.0	-0.024	-1000.0
Arf6 downstream pathway	2.0	91.0	43.0	-0.031	0.036	1000.0	-1000.0	-0.021	-1000.0
IGF1 pathway	2.0	114.0	57.0	-0.046	0.054	1000.0	-1000.0	-0.052	-1000.0
Aurora A signaling	1.0	102.0	60.0	-0.023	0.052	1000.0	-1000.0	-0.009	-1000.0
Class I PI3K signaling events mediated by Akt	1.0	86.0	68.0	-0.044	0.059	1000.0	-1000.0	-0.022	-1000.0
HIF-2-alpha transcription factor network	1.0	75.0	43.0	-0.161	0.164	1000.0	-1000.0	-0.047	-1000.0
Arf6 trafficking events	1.0	119.0	71.0	-0.028	0.049	1000.0	-1000.0	-0.036	-1000.0
VEGFR1 specific signals	1.0	111.0	56.0	-0.052	0.064	1000.0	-1000.0	-0.022	-1000.0
Arf1 pathway	1.0	105.0	54.0	-0.034	0.034	1000.0	-1000.0	-0.01	-1000.0
Regulation of cytoplasmic and nuclear SMAD2/3 signaling	0.0	0.0	23.0	0.015	0.056	1000.0	-1000.0	-0.015	-1000.0
BARD1 signaling events	0.0	4.0	57.0	-0.047	0.08	1000.0	-1000.0	-0.015	-1000.0
PLK2 and PLK4 events	0.0	2.0	3.0	0.017	0.025	1000.0	-1000.0	0.0	-1000.0
Circadian rhythm pathway	0.0	12.0	22.0	-0.016	0.06	1000.0	-1000.0	-0.024	-1000.0
PLK1 signaling events	0.0	45.0	85.0	-0.013	0.05	1000.0	-1000.0	-0.024	-1000.0
mTOR signaling pathway	0.0	18.0	53.0	-0.005	0.041	1000.0	-1000.0	-0.039	-1000.0
Sumoylation by RanBP2 regulates transcriptional repression	0.0	9.0	27.0	-0.001	0.046	1000.0	-1000.0	-0.031	-1000.0
Alternative NF-kappaB pathway	0.0	0.0	13.0	0.0	0.056	1000.0	-1000.0	-0.005	-1000.0
Total	3147	187721	7203	-21.5092197036	7.57466909703	131000	-131000	-3.88295890264	-131000