Signaling events mediated by the Hedgehog family Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations TGFB2 -0.031 0.131 -9999.0 0.0 -0.496 10.0 10.0 IHH -0.029 0.145 -9999.0 0.0 -0.39 35.0 35.0 SHH Np/Cholesterol/GAS1 -0.011 0.084 -9999.0 0.0 -0.202 42.0 42.0 LRPAP1 0.026 0.005 -9999.0 0.0 -9999.0 0.0 0.0 dorsoventral neural tube patterning 0.011 0.084 0.201 42.0 -9999.0 0.0 42.0 SMO/beta Arrestin2 -0.021 0.135 -9999.0 0.0 -0.415 15.0 15.0 SMO -0.033 0.131 -9999.0 0.0 -0.418 17.0 17.0 AKT1 -0.022 0.137 -9999.0 0.0 -0.485 15.0 15.0 ARRB2 0.026 0.007 -9999.0 0.0 -9999.0 0.0 0.0 BOC 0.004 0.091 -9999.0 0.0 -0.358 16.0 16.0 ADRBK1 0.026 0.006 -9999.0 0.0 -9999.0 0.0 0.0 heart looping -0.033 0.129 -9999.0 0.0 -0.413 17.0 17.0 STIL -0.06 0.122 0.187 6.0 -0.322 28.0 34.0 DHH N/PTCH2 0.009 0.083 -9999.0 0.0 -0.21 33.0 33.0 DHH N/PTCH1 -0.01 0.11 -9999.0 0.0 -0.339 12.0 12.0 PIK3CA 0.026 0.007 -9999.0 0.0 -9999.0 0.0 0.0 DHH 0.019 0.055 -9999.0 0.0 -0.345 6.0 6.0 PTHLH -0.043 0.17 -9999.0 0.0 -0.645 13.0 13.0 determination of left/right symmetry -0.033 0.129 -9999.0 0.0 -0.413 17.0 17.0 PIK3R1 0.025 0.007 -9999.0 0.0 -9999.0 0.0 0.0 skeletal system development -0.043 0.169 -9999.0 0.0 -0.639 13.0 13.0 IHH N/Hhip -0.074 0.171 -9999.0 0.0 -0.331 76.0 76.0 DHH N/Hhip -0.042 0.136 -9999.0 0.0 -0.267 71.0 71.0 mol:Cholesterol 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 heart development -0.033 0.129 -9999.0 0.0 -0.413 17.0 17.0 pancreas development -0.073 0.173 -9999.0 0.0 -0.375 67.0 67.0 HHAT 0.023 0.035 -9999.0 0.0 -0.375 2.0 2.0 PI3K 0.035 0.014 -9999.0 0.0 -9999.0 0.0 0.0 EntrezGene:84976 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 GAS1 0.001 0.094 -9999.0 0.0 -0.35 18.0 18.0 somite specification -0.033 0.129 -9999.0 0.0 -0.413 17.0 17.0 SHH Np/Cholesterol/PTCH1 -0.032 0.11 -9999.0 0.0 -0.315 19.0 19.0 SHH Np/Cholesterol/PTCH2 -0.018 0.084 -9999.0 0.0 -0.175 57.0 57.0 SHH Np/Cholesterol/Megalin -0.029 0.092 -9999.0 0.0 -0.178 71.0 71.0 SHH -0.018 0.088 -9999.0 0.0 -0.264 30.0 30.0 catabolic process -0.021 0.112 -9999.0 0.0 -0.378 11.0 11.0 SMO/Vitamin D3 -0.036 0.125 -9999.0 0.0 -0.379 17.0 17.0 SHH Np/Cholesterol/Hhip -0.05 0.124 -9999.0 0.0 -0.235 78.0 78.0 LRP2 -0.031 0.123 -9999.0 0.0 -0.294 48.0 48.0 receptor-mediated endocytosis -0.053 0.126 -9999.0 0.0 -0.361 22.0 22.0 SHH Np/Cholesterol/BOC -0.01 0.085 -9999.0 0.0 -0.205 41.0 41.0 SHH Np/Cholesterol/CDO -0.004 0.074 -9999.0 0.0 -0.193 35.0 35.0 mesenchymal cell differentiation 0.05 0.124 0.233 78.0 -9999.0 0.0 78.0 mol:Vitamin D3 -0.029 0.114 0.201 6.0 -0.322 18.0 24.0 IHH N/PTCH2 -0.024 0.116 -9999.0 0.0 -0.237 56.0 56.0 CDON 0.017 0.056 -9999.0 0.0 -0.323 7.0 7.0 IHH N/PTCH1 -0.014 0.116 -9999.0 0.0 -0.381 11.0 11.0 Megalin/LRPAP1 -0.004 0.091 -9999.0 0.0 -0.202 47.0 47.0 PTCH2 -0.005 0.096 -9999.0 0.0 -0.288 28.0 28.0 SHH Np/Cholesterol -0.008 0.068 -9999.0 0.0 -0.198 30.0 30.0 PTCH1 -0.021 0.112 -9999.0 0.0 -0.379 11.0 11.0 HHIP -0.073 0.173 -9999.0 0.0 -0.375 67.0 67.0