Stabilization and expansion of the E-cadherin adherens junction Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations adherens junction organization -0.06 0.132 -9999.0 0.0 -0.353 25.0 25.0 epithelial cell differentiation -0.087 0.189 -9999.0 0.0 -0.508 25.0 25.0 CYFIP2 0.011 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ENAH -0.037 0.17 -9999.0 0.0 -0.511 4.0 4.0 EGFR -0.043 0.189 -9999.0 0.0 -0.61 13.0 13.0 EPHA2 -0.1 0.29 -9999.0 0.0 -0.826 20.0 20.0 MYO6 -0.052 0.194 -9999.0 0.0 -0.483 25.0 25.0 CTNNB1 0.011 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ABI1/Sra1/Nap1 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 AQP5 -0.093 0.192 -9999.0 0.0 -0.705 5.0 5.0 CTNND1 0.011 0.0 -9999.0 0.0 -9999.0 0.0 0.0 mol:PI-4-5-P2 -0.05 0.191 -9999.0 0.0 -0.474 25.0 25.0 regulation of calcium-dependent cell-cell adhesion -0.051 0.194 -9999.0 0.0 -0.481 25.0 25.0 EGF -0.021 0.162 -9999.0 0.0 -0.793 6.0 6.0 NCKAP1 0.011 0.0 -9999.0 0.0 -9999.0 0.0 0.0 AQP3 -0.076 0.162 -9999.0 0.0 -0.632 1.0 1.0 cortical microtubule organization -0.087 0.189 -9999.0 0.0 -0.508 25.0 25.0 GO:0000145 -0.047 0.182 -9999.0 0.0 -0.452 25.0 25.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin -0.088 0.192 -9999.0 0.0 -0.514 25.0 25.0 MLLT4 0.011 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ARF6/GDP -0.119 0.203 -9999.0 0.0 -0.742 5.0 5.0 ARF6 0.011 0.0 -9999.0 0.0 -9999.0 0.0 0.0 Ephrin A1/EPHA2/NCK1/GIT1 -0.07 0.176 -9999.0 0.0 -0.541 18.0 18.0 mol:Ca2+ -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 VASP -0.037 0.183 -9999.0 0.0 -0.444 25.0 25.0 PVRL2 0.011 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ZYX -0.052 0.194 -9999.0 0.0 -0.483 25.0 25.0 ARF6/GTP -0.064 0.162 -9999.0 0.0 -0.498 18.0 18.0 CDH1 -0.142 0.331 -9999.0 0.0 -0.839 27.0 27.0 EGFR/EGFR/EGF/EGF -0.121 0.232 -9999.0 0.0 -0.545 31.0 31.0 RhoA/GDP -0.081 0.178 -9999.0 0.0 -0.477 25.0 25.0 actin cytoskeleton organization -0.044 0.186 -9999.0 0.0 -0.454 25.0 25.0 IGF-1R heterotetramer 0.011 0.0 -9999.0 0.0 -9999.0 0.0 0.0 GIT1 0.011 0.0 -9999.0 0.0 -9999.0 0.0 0.0 IGF1R 0.011 0.0 -9999.0 0.0 -9999.0 0.0 0.0 IGF1 -0.117 0.299 -9999.0 0.0 -0.757 25.0 25.0 DIAPH1 -0.008 0.015 -9999.0 0.0 -9999.0 0.0 0.0 Wnt receptor signaling pathway 0.087 0.189 0.508 25.0 -9999.0 0.0 25.0 RHOA 0.011 0.0 -9999.0 0.0 -9999.0 0.0 0.0 RhoA/GTP -0.119 0.204 -9999.0 0.0 -0.744 5.0 5.0 CTNNA1 0.011 0.0 -9999.0 0.0 -9999.0 0.0 0.0 VCL -0.046 0.19 -9999.0 0.0 -0.467 25.0 25.0 EFNA1 0.006 0.045 -9999.0 0.0 -0.384 2.0 2.0 LPP -0.043 0.186 -9999.0 0.0 -0.453 25.0 25.0 Ephrin A1/EPHA2 -0.139 0.237 -9999.0 0.0 -0.517 39.0 39.0 SEC6/SEC8 -0.072 0.158 -9999.0 0.0 -9999.0 0.0 0.0 MGAT3 -0.053 0.197 -9999.0 0.0 -0.49 25.0 25.0 HGF/MET -0.16 0.242 -9999.0 0.0 -0.54 36.0 36.0 HGF -0.139 0.273 -9999.0 0.0 -0.539 41.0 41.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin/EPLIN -0.06 0.133 -9999.0 0.0 -0.356 25.0 25.0 actin cable formation -0.009 0.15 -9999.0 0.0 -0.419 4.0 4.0 KIAA1543 -0.055 0.2 -9999.0 0.0 -0.46 29.0 29.0 KIFC3 -0.055 0.197 -9999.0 0.0 -0.483 26.0 26.0 NCK1 0.011 0.0 -9999.0 0.0 -9999.0 0.0 0.0 EXOC3 0.011 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ACTN1 -0.052 0.194 -9999.0 0.0 -0.483 25.0 25.0 NCK1/GIT1 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 mol:GDP -0.087 0.189 -9999.0 0.0 -0.508 25.0 25.0 EXOC4 0.011 0.0 -9999.0 0.0 -9999.0 0.0 0.0 STX4 -0.052 0.194 -9999.0 0.0 -0.483 25.0 25.0 PIP5K1C -0.052 0.194 -9999.0 0.0 -0.483 25.0 25.0 LIMA1 0.011 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ABI1 0.011 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ROCK1 -0.102 0.173 -9999.0 0.0 -0.609 5.0 5.0 adherens junction assembly -0.039 0.191 -9999.0 0.0 -9999.0 0.0 0.0 IGF-1R heterotetramer/IGF1 -0.144 0.209 -9999.0 0.0 -0.465 44.0 44.0 nectin-2(dimer)/I-afadin/I-afadin/nectin-2(dimer/I-afadin/I-afadin 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 MET -0.02 0.152 -9999.0 0.0 -0.665 7.0 7.0 PLEKHA7 -0.066 0.206 -9999.0 0.0 -0.484 29.0 29.0 mol:GTP -0.069 0.175 -9999.0 0.0 -0.536 18.0 18.0 establishment of epithelial cell apical/basal polarity -0.017 0.173 -9999.0 0.0 -9999.0 0.0 0.0 cortical actin cytoskeleton stabilization -0.06 0.132 -9999.0 0.0 -0.353 25.0 25.0 regulation of cell-cell adhesion -0.044 0.186 -9999.0 0.0 -0.454 25.0 25.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin/EPLIN/cortical actin cytoskeleton -0.06 0.133 -9999.0 0.0 -0.356 25.0 25.0