Signaling events mediated by the Hedgehog family Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations TGFB2 -0.226 0.407 -9999.0 0.0 -0.893 36.0 36.0 IHH -0.123 0.304 -9999.0 0.0 -0.726 28.0 28.0 SHH Np/Cholesterol/GAS1 -0.053 0.165 -9999.0 0.0 -0.395 28.0 28.0 LRPAP1 0.025 0.005 -9999.0 0.0 -9999.0 0.0 0.0 dorsoventral neural tube patterning 0.053 0.164 0.392 28.0 -9999.0 0.0 28.0 SMO/beta Arrestin2 -0.141 0.237 -9999.0 0.0 -0.611 15.0 15.0 SMO -0.145 0.246 -9999.0 0.0 -0.525 34.0 34.0 AKT1 -0.051 0.138 -9999.0 0.0 -0.69 3.0 3.0 ARRB2 0.025 0.005 -9999.0 0.0 -9999.0 0.0 0.0 BOC 0.001 0.162 -9999.0 0.0 -0.67 8.0 8.0 ADRBK1 0.023 0.007 -9999.0 0.0 -9999.0 0.0 0.0 heart looping -0.148 0.241 -9999.0 0.0 -0.516 34.0 34.0 STIL -0.16 0.23 0.327 1.0 -0.632 15.0 16.0 DHH N/PTCH2 0.014 0.133 -9999.0 0.0 -0.563 7.0 7.0 DHH N/PTCH1 -0.129 0.248 -9999.0 0.0 -0.431 55.0 55.0 PIK3CA 0.025 0.004 -9999.0 0.0 -9999.0 0.0 0.0 DHH 0.004 0.14 -9999.0 0.0 -0.67 6.0 6.0 PTHLH -0.247 0.386 -9999.0 0.0 -0.871 35.0 35.0 determination of left/right symmetry -0.148 0.241 -9999.0 0.0 -0.516 34.0 34.0 PIK3R1 0.02 0.057 -9999.0 0.0 -0.67 1.0 1.0 skeletal system development -0.244 0.381 -9999.0 0.0 -0.859 35.0 35.0 IHH N/Hhip -0.162 0.325 -9999.0 0.0 -0.614 47.0 47.0 DHH N/Hhip -0.082 0.25 -9999.0 0.0 -0.522 35.0 35.0 mol:Cholesterol 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 heart development -0.148 0.241 -9999.0 0.0 -0.516 34.0 34.0 pancreas development -0.106 0.285 -9999.0 0.0 -0.659 31.0 31.0 HHAT 0.025 0.004 -9999.0 0.0 -9999.0 0.0 0.0 PI3K 0.032 0.045 -9999.0 0.0 -0.506 1.0 1.0 EntrezGene:84976 -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 GAS1 0.018 0.082 -9999.0 0.0 -0.67 2.0 2.0 somite specification -0.148 0.241 -9999.0 0.0 -0.516 34.0 34.0 SHH Np/Cholesterol/PTCH1 -0.169 0.239 -9999.0 0.0 -0.454 44.0 44.0 SHH Np/Cholesterol/PTCH2 -0.057 0.166 -9999.0 0.0 -0.402 28.0 28.0 SHH Np/Cholesterol/Megalin -0.122 0.244 -9999.0 0.0 -0.445 51.0 51.0 SHH -0.08 0.196 -9999.0 0.0 -0.507 26.0 26.0 catabolic process -0.14 0.243 -9999.0 0.0 -0.444 55.0 55.0 SMO/Vitamin D3 -0.165 0.261 0.473 1.0 -0.712 14.0 15.0 SHH Np/Cholesterol/Hhip -0.126 0.246 -9999.0 0.0 -0.476 45.0 45.0 LRP2 -0.099 0.294 -9999.0 0.0 -0.67 31.0 31.0 receptor-mediated endocytosis -0.224 0.282 -9999.0 0.0 -0.674 30.0 30.0 SHH Np/Cholesterol/BOC -0.063 0.192 -9999.0 0.0 -0.42 32.0 32.0 SHH Np/Cholesterol/CDO -0.056 0.157 -9999.0 0.0 -0.396 26.0 26.0 mesenchymal cell differentiation 0.125 0.244 0.472 45.0 -9999.0 0.0 45.0 mol:Vitamin D3 -0.161 0.252 0.434 1.0 -0.471 39.0 40.0 IHH N/PTCH2 -0.072 0.212 -9999.0 0.0 -0.478 30.0 30.0 CDON 0.016 0.031 -9999.0 0.0 -0.342 1.0 1.0 IHH N/PTCH1 -0.127 0.258 -9999.0 0.0 -0.448 55.0 55.0 Megalin/LRPAP1 -0.062 0.228 -9999.0 0.0 -0.506 31.0 31.0 PTCH2 0.016 0.08 -9999.0 0.0 -0.67 2.0 2.0 SHH Np/Cholesterol -0.059 0.157 -9999.0 0.0 -0.401 26.0 26.0 PTCH1 -0.141 0.243 -9999.0 0.0 -0.445 55.0 55.0 HHIP -0.106 0.285 -9999.0 0.0 -0.66 31.0 31.0