Stabilization and expansion of the E-cadherin adherens junction Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations adherens junction organization -0.03 0.119 -9999.0 0.0 -0.295 25.0 25.0 epithelial cell differentiation -0.023 0.16 -9999.0 0.0 -0.377 25.0 25.0 CYFIP2 0.025 0.005 -9999.0 0.0 -9999.0 0.0 0.0 ENAH -0.065 0.131 0.433 1.0 -0.433 4.0 5.0 EGFR -0.002 0.138 -9999.0 0.0 -0.67 6.0 6.0 EPHA2 -0.053 0.221 -9999.0 0.0 -0.67 17.0 17.0 MYO6 -0.043 0.147 -9999.0 0.0 -0.364 25.0 25.0 CTNNB1 0.026 0.002 -9999.0 0.0 -9999.0 0.0 0.0 ABI1/Sra1/Nap1 0.048 0.015 -9999.0 0.0 -9999.0 0.0 0.0 AQP5 -0.05 0.16 -9999.0 0.0 -0.562 5.0 5.0 CTNND1 0.024 0.007 -9999.0 0.0 -9999.0 0.0 0.0 mol:PI-4-5-P2 -0.042 0.144 -9999.0 0.0 -0.358 25.0 25.0 regulation of calcium-dependent cell-cell adhesion -0.043 0.145 -9999.0 0.0 -0.359 25.0 25.0 EGF 0.002 0.125 -9999.0 0.0 -0.67 5.0 5.0 NCKAP1 0.026 0.0 -9999.0 0.0 -9999.0 0.0 0.0 AQP3 -0.044 0.14 -9999.0 0.0 -0.567 1.0 1.0 cortical microtubule organization -0.023 0.16 -9999.0 0.0 -0.377 25.0 25.0 GO:0000145 -0.054 0.133 -9999.0 0.0 -0.342 25.0 25.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin -0.019 0.163 -9999.0 0.0 -0.381 25.0 25.0 MLLT4 0.025 0.003 -9999.0 0.0 -9999.0 0.0 0.0 ARF6/GDP -0.096 0.157 -9999.0 0.0 -0.357 37.0 37.0 ARF6 0.025 0.004 -9999.0 0.0 -9999.0 0.0 0.0 Ephrin A1/EPHA2/NCK1/GIT1 0.009 0.149 -9999.0 0.0 -0.404 17.0 17.0 mol:Ca2+ 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 VASP -0.044 0.13 -9999.0 0.0 -0.334 23.0 23.0 PVRL2 0.025 0.005 -9999.0 0.0 -9999.0 0.0 0.0 ZYX -0.044 0.144 -9999.0 0.0 -0.365 24.0 24.0 ARF6/GTP 0.017 0.143 -9999.0 0.0 -0.378 17.0 17.0 CDH1 -0.091 0.259 -9999.0 0.0 -0.67 25.0 25.0 EGFR/EGFR/EGF/EGF -0.049 0.188 -9999.0 0.0 -0.416 28.0 28.0 RhoA/GDP -0.019 0.154 -9999.0 0.0 -0.36 25.0 25.0 actin cytoskeleton organization -0.048 0.139 -9999.0 0.0 -0.351 25.0 25.0 IGF-1R heterotetramer 0.025 0.004 -9999.0 0.0 -9999.0 0.0 0.0 GIT1 0.025 0.003 -9999.0 0.0 -9999.0 0.0 0.0 IGF1R 0.025 0.004 -9999.0 0.0 -9999.0 0.0 0.0 IGF1 -0.059 0.233 -9999.0 0.0 -0.67 19.0 19.0 DIAPH1 0.001 0.153 -9999.0 0.0 -0.67 2.0 2.0 Wnt receptor signaling pathway 0.023 0.16 0.377 25.0 -9999.0 0.0 25.0 RHOA 0.026 0.002 -9999.0 0.0 -9999.0 0.0 0.0 RhoA/GTP -0.097 0.158 -9999.0 0.0 -0.357 38.0 38.0 CTNNA1 0.025 0.004 -9999.0 0.0 -9999.0 0.0 0.0 VCL -0.049 0.142 -9999.0 0.0 -0.36 25.0 25.0 EFNA1 0.026 0.01 -9999.0 0.0 -9999.0 0.0 0.0 LPP -0.056 0.132 -9999.0 0.0 -0.349 24.0 24.0 Ephrin A1/EPHA2 -0.067 0.196 -9999.0 0.0 -0.39 38.0 38.0 SEC6/SEC8 -0.046 0.129 -9999.0 0.0 -0.338 24.0 24.0 MGAT3 -0.044 0.147 -9999.0 0.0 -0.365 25.0 25.0 HGF/MET -0.054 0.194 -9999.0 0.0 -0.402 33.0 33.0 HGF -0.008 0.18 -9999.0 0.0 -0.67 10.0 10.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin/EPLIN -0.03 0.12 -9999.0 0.0 -0.297 25.0 25.0 actin cable formation -0.037 0.129 0.361 2.0 -0.339 5.0 7.0 KIAA1543 -0.065 0.139 -9999.0 0.0 -0.347 28.0 28.0 KIFC3 -0.049 0.146 -9999.0 0.0 -0.364 26.0 26.0 NCK1 0.026 0.002 -9999.0 0.0 -9999.0 0.0 0.0 EXOC3 0.025 0.005 -9999.0 0.0 -9999.0 0.0 0.0 ACTN1 -0.043 0.147 -9999.0 0.0 -0.364 25.0 25.0 NCK1/GIT1 0.037 0.005 -9999.0 0.0 -9999.0 0.0 0.0 mol:GDP -0.023 0.16 -9999.0 0.0 -0.377 25.0 25.0 EXOC4 0.024 0.006 -9999.0 0.0 -9999.0 0.0 0.0 STX4 -0.043 0.147 -9999.0 0.0 -0.364 25.0 25.0 PIP5K1C -0.043 0.147 -9999.0 0.0 -0.364 25.0 25.0 LIMA1 0.025 0.003 -9999.0 0.0 -9999.0 0.0 0.0 ABI1 0.024 0.006 -9999.0 0.0 -9999.0 0.0 0.0 ROCK1 -0.074 0.155 0.455 1.0 -0.525 4.0 5.0 adherens junction assembly -0.058 0.145 -9999.0 0.0 -0.403 5.0 5.0 IGF-1R heterotetramer/IGF1 -0.071 0.18 -9999.0 0.0 -0.356 42.0 42.0 nectin-2(dimer)/I-afadin/I-afadin/nectin-2(dimer/I-afadin/I-afadin 0.036 0.008 -9999.0 0.0 -9999.0 0.0 0.0 MET 0.007 0.113 -9999.0 0.0 -0.67 4.0 4.0 PLEKHA7 -0.054 0.152 -9999.0 0.0 -0.363 28.0 28.0 mol:GTP 0.008 0.147 -9999.0 0.0 -0.401 17.0 17.0 establishment of epithelial cell apical/basal polarity -0.044 0.135 0.319 1.0 -9999.0 0.0 1.0 cortical actin cytoskeleton stabilization -0.03 0.119 -9999.0 0.0 -0.295 25.0 25.0 regulation of cell-cell adhesion -0.048 0.139 -9999.0 0.0 -0.351 25.0 25.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin/EPLIN/cortical actin cytoskeleton -0.03 0.12 -9999.0 0.0 -0.297 25.0 25.0