Stabilization and expansion of the E-cadherin adherens junction Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations adherens junction organization 0.033 0.0 -9999.0 0.0 -9999.0 0.0 0.0 epithelial cell differentiation 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 CYFIP2 0.013 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ENAH 0.07 0.009 -9999.0 0.0 -9999.0 0.0 0.0 EGFR 0.005 0.082 -9999.0 0.0 -0.816 5.0 5.0 EPHA2 0.011 0.025 -9999.0 0.0 -0.314 3.0 3.0 MYO6 0.041 0.0 -9999.0 0.0 -9999.0 0.0 0.0 CTNNB1 0.013 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ABI1/Sra1/Nap1 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 AQP5 -0.039 0.13 -9999.0 0.0 -0.589 26.0 26.0 CTNND1 0.013 0.0 -9999.0 0.0 -9999.0 0.0 0.0 mol:PI-4-5-P2 0.04 0.0 -9999.0 0.0 -9999.0 0.0 0.0 regulation of calcium-dependent cell-cell adhesion -0.037 0.074 -9999.0 0.0 -9999.0 0.0 0.0 EGF -0.11 0.292 -9999.0 0.0 -0.778 78.0 78.0 NCKAP1 0.013 0.0 -9999.0 0.0 -9999.0 0.0 0.0 AQP3 -0.071 0.191 -9999.0 0.0 -0.589 60.0 60.0 cortical microtubule organization 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 GO:0000145 0.039 0.0 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 MLLT4 0.013 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ARF6/GDP -0.0 0.005 -9999.0 0.0 -9999.0 0.0 0.0 ARF6 0.013 0.0 -9999.0 0.0 -9999.0 0.0 0.0 Ephrin A1/EPHA2/NCK1/GIT1 -0.001 0.01 -9999.0 0.0 -9999.0 0.0 0.0 mol:Ca2+ 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 VASP 0.048 0.033 -9999.0 0.0 -9999.0 0.0 0.0 PVRL2 0.013 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ZYX 0.041 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ARF6/GTP -0.001 0.009 -9999.0 0.0 -9999.0 0.0 0.0 CDH1 0.013 0.0 -9999.0 0.0 -9999.0 0.0 0.0 EGFR/EGFR/EGF/EGF -0.066 0.152 -9999.0 0.0 -0.422 77.0 77.0 RhoA/GDP 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 actin cytoskeleton organization 0.047 0.0 -9999.0 0.0 -9999.0 0.0 0.0 IGF-1R heterotetramer 0.013 0.0 -9999.0 0.0 -9999.0 0.0 0.0 GIT1 0.013 0.0 -9999.0 0.0 -9999.0 0.0 0.0 IGF1R 0.013 0.0 -9999.0 0.0 -9999.0 0.0 0.0 IGF1 -0.179 0.348 -9999.0 0.0 -0.791 120.0 120.0 DIAPH1 0.0 0.002 -9999.0 0.0 -9999.0 0.0 0.0 Wnt receptor signaling pathway 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 RHOA 0.013 0.0 -9999.0 0.0 -9999.0 0.0 0.0 RhoA/GTP -0.0 0.005 -9999.0 0.0 -9999.0 0.0 0.0 CTNNA1 0.013 0.0 -9999.0 0.0 -9999.0 0.0 0.0 VCL 0.047 0.0 -9999.0 0.0 -9999.0 0.0 0.0 EFNA1 0.013 0.0 -9999.0 0.0 -9999.0 0.0 0.0 LPP 0.04 0.059 -9999.0 0.0 -0.424 8.0 8.0 Ephrin A1/EPHA2 -0.001 0.007 -9999.0 0.0 -9999.0 0.0 0.0 SEC6/SEC8 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 MGAT3 -0.038 0.075 -9999.0 0.0 -9999.0 0.0 0.0 HGF/MET -0.1 0.162 -9999.0 0.0 -0.467 75.0 75.0 HGF -0.111 0.296 -9999.0 0.0 -0.816 75.0 75.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin/EPLIN 0.033 0.0 -9999.0 0.0 -9999.0 0.0 0.0 actin cable formation 0.085 0.021 -9999.0 0.0 -9999.0 0.0 0.0 KIAA1543 0.047 0.021 -9999.0 0.0 -0.416 1.0 1.0 KIFC3 0.041 0.0 -9999.0 0.0 -9999.0 0.0 0.0 NCK1 0.013 0.0 -9999.0 0.0 -9999.0 0.0 0.0 EXOC3 0.013 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ACTN1 0.04 0.007 -9999.0 0.0 -9999.0 0.0 0.0 NCK1/GIT1 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 mol:GDP 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 EXOC4 0.013 0.0 -9999.0 0.0 -9999.0 0.0 0.0 STX4 0.041 0.0 -9999.0 0.0 -9999.0 0.0 0.0 PIP5K1C 0.041 0.0 -9999.0 0.0 -9999.0 0.0 0.0 LIMA1 0.013 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ABI1 0.013 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ROCK1 -0.0 0.004 -9999.0 0.0 -9999.0 0.0 0.0 adherens junction assembly 0.064 0.019 -9999.0 0.0 -9999.0 0.0 0.0 IGF-1R heterotetramer/IGF1 -0.097 0.177 -9999.0 0.0 -0.422 114.0 114.0 nectin-2(dimer)/I-afadin/I-afadin/nectin-2(dimer/I-afadin/I-afadin 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 MET -0.105 0.157 -9999.0 0.0 -0.314 182.0 182.0 PLEKHA7 0.04 0.022 -9999.0 0.0 -0.443 1.0 1.0 mol:GTP -0.001 0.01 -9999.0 0.0 -9999.0 0.0 0.0 establishment of epithelial cell apical/basal polarity 0.067 0.0 -9999.0 0.0 -9999.0 0.0 0.0 cortical actin cytoskeleton stabilization 0.033 0.0 -9999.0 0.0 -9999.0 0.0 0.0 regulation of cell-cell adhesion 0.047 0.0 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin/EPLIN/cortical actin cytoskeleton 0.033 0.0 -9999.0 0.0 -9999.0 0.0 0.0