Signaling events mediated by the Hedgehog family Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations TGFB2 -0.088 0.209 -9999.0 0.0 -0.616 31.0 31.0 IHH -0.152 0.313 -9999.0 0.0 -0.701 121.0 121.0 SHH Np/Cholesterol/GAS1 -0.053 0.158 -9999.0 0.0 -0.397 83.0 83.0 LRPAP1 0.027 0.004 -9999.0 0.0 -9999.0 0.0 0.0 dorsoventral neural tube patterning 0.053 0.157 0.392 84.0 -9999.0 0.0 84.0 SMO/beta Arrestin2 -0.074 0.205 -9999.0 0.0 -0.417 110.0 110.0 SMO -0.095 0.207 -9999.0 0.0 -0.437 118.0 118.0 AKT1 -0.016 0.105 -9999.0 0.0 -0.609 2.0 2.0 ARRB2 0.026 0.007 -9999.0 0.0 -9999.0 0.0 0.0 BOC 0.016 0.088 -9999.0 0.0 -0.674 8.0 8.0 ADRBK1 0.027 0.005 -9999.0 0.0 -9999.0 0.0 0.0 heart looping -0.094 0.204 -9999.0 0.0 -0.431 118.0 118.0 STIL -0.065 0.159 0.267 1.0 -0.488 14.0 15.0 DHH N/PTCH2 -0.051 0.205 -9999.0 0.0 -0.51 81.0 81.0 DHH N/PTCH1 -0.076 0.188 -9999.0 0.0 -0.371 129.0 129.0 PIK3CA 0.023 0.054 -9999.0 0.0 -0.674 3.0 3.0 DHH 0.021 0.063 -9999.0 0.0 -0.674 4.0 4.0 PTHLH -0.137 0.31 -9999.0 0.0 -1.049 32.0 32.0 determination of left/right symmetry -0.094 0.204 -9999.0 0.0 -0.431 118.0 118.0 PIK3R1 0.026 0.005 -9999.0 0.0 -9999.0 0.0 0.0 skeletal system development -0.135 0.305 -9999.0 0.0 -1.031 32.0 32.0 IHH N/Hhip -0.292 0.332 -9999.0 0.0 -0.591 260.0 260.0 DHH N/Hhip -0.172 0.266 -9999.0 0.0 -0.507 191.0 191.0 mol:Cholesterol -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 heart development -0.094 0.204 -9999.0 0.0 -0.431 118.0 118.0 pancreas development -0.249 0.332 -9999.0 0.0 -0.671 190.0 190.0 HHAT 0.024 0.032 -9999.0 0.0 -0.674 1.0 1.0 PI3K 0.036 0.043 -9999.0 0.0 -0.508 3.0 3.0 EntrezGene:84976 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 GAS1 -0.1 0.262 -9999.0 0.0 -0.631 95.0 95.0 somite specification -0.094 0.204 -9999.0 0.0 -0.431 118.0 118.0 SHH Np/Cholesterol/PTCH1 -0.07 0.159 -9999.0 0.0 -0.337 108.0 108.0 SHH Np/Cholesterol/PTCH2 -0.043 0.15 -9999.0 0.0 -0.378 80.0 80.0 SHH Np/Cholesterol/Megalin -0.081 0.179 -9999.0 0.0 -0.409 107.0 107.0 SHH -0.005 0.029 -9999.0 0.0 -0.508 1.0 1.0 catabolic process -0.093 0.202 -9999.0 0.0 -0.404 142.0 142.0 SMO/Vitamin D3 -0.075 0.183 -9999.0 0.0 -0.383 109.0 109.0 SHH Np/Cholesterol/Hhip -0.139 0.201 -9999.0 0.0 -0.391 190.0 190.0 LRP2 -0.155 0.305 -9999.0 0.0 -0.662 132.0 132.0 receptor-mediated endocytosis -0.139 0.21 -9999.0 0.0 -0.601 42.0 42.0 SHH Np/Cholesterol/BOC 0.014 0.056 -9999.0 0.0 -0.372 9.0 9.0 SHH Np/Cholesterol/CDO -0.095 0.185 -9999.0 0.0 -0.38 143.0 143.0 mesenchymal cell differentiation 0.138 0.2 0.388 190.0 -9999.0 0.0 190.0 mol:Vitamin D3 -0.064 0.167 -9999.0 0.0 -0.341 108.0 108.0 IHH N/PTCH2 -0.169 0.288 -9999.0 0.0 -0.534 179.0 179.0 CDON -0.179 0.319 -9999.0 0.0 -0.672 147.0 147.0 IHH N/PTCH1 -0.091 0.207 -9999.0 0.0 -0.409 142.0 142.0 Megalin/LRPAP1 -0.103 0.238 -9999.0 0.0 -0.497 132.0 132.0 PTCH2 -0.085 0.256 -9999.0 0.0 -0.67 80.0 80.0 SHH Np/Cholesterol 0.009 0.023 -9999.0 0.0 -0.403 1.0 1.0 PTCH1 -0.094 0.203 -9999.0 0.0 -0.405 142.0 142.0 HHIP -0.25 0.332 -9999.0 0.0 -0.672 190.0 190.0