This pipeline computes the correlation between significant copy number variation (cnv focal) genes and molecular subtypes.
Testing the association between copy number variation 12 focal events and 8 molecular subtypes across 123 patients, 28 significant findings detected with P value < 0.05 and Q value < 0.25.
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del_3p22.2 cnv correlated to 'CN_CNMF', 'METHLYATION_CNMF', and 'MIRSEQ_MATURE_CNMF'.
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del_6p25.2 cnv correlated to 'CN_CNMF', 'METHLYATION_CNMF', 'MRNASEQ_CNMF', 'MRNASEQ_CHIERARCHICAL', 'MIRSEQ_CNMF', and 'MIRSEQ_MATURE_CNMF'.
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del_6q21 cnv correlated to 'CN_CNMF', 'METHLYATION_CNMF', 'MRNASEQ_CNMF', 'MRNASEQ_CHIERARCHICAL', 'MIRSEQ_CNMF', 'MIRSEQ_CHIERARCHICAL', 'MIRSEQ_MATURE_CNMF', and 'MIRSEQ_MATURE_CHIERARCHICAL'.
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del_7q36.3 cnv correlated to 'MRNASEQ_CNMF'.
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del_9p21.3 cnv correlated to 'MRNASEQ_CNMF', 'MRNASEQ_CHIERARCHICAL', and 'MIRSEQ_CHIERARCHICAL'.
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del_11q22.1 cnv correlated to 'CN_CNMF', 'METHLYATION_CNMF', and 'MIRSEQ_MATURE_CNMF'.
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del_19p13.11 cnv correlated to 'MRNASEQ_CNMF' and 'MRNASEQ_CHIERARCHICAL'.
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del_22q12.1 cnv correlated to 'CN_CNMF'.
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del_22q13.32 cnv correlated to 'CN_CNMF'.
Clinical Features |
CN CNMF |
METHLYATION CNMF |
MRNASEQ CNMF |
MRNASEQ CHIERARCHICAL |
MIRSEQ CNMF |
MIRSEQ CHIERARCHICAL |
MIRSEQ MATURE CNMF |
MIRSEQ MATURE CHIERARCHICAL |
||
nCNV (%) | nWild-Type | Fisher's exact test | Fisher's exact test | Fisher's exact test | Fisher's exact test | Fisher's exact test | Fisher's exact test | Fisher's exact test | Fisher's exact test | |
del 6q21 | 20 (16%) | 103 |
1e-05 (0.00096) |
1e-05 (0.00096) |
1e-05 (0.00096) |
1e-05 (0.00096) |
4e-05 (0.00332) |
0.00015 (0.0115) |
1e-05 (0.00096) |
5e-05 (0.004) |
del 6p25 2 | 26 (21%) | 97 |
1e-05 (0.00096) |
1e-05 (0.00096) |
0.00149 (0.106) |
6e-05 (0.00474) |
0.0011 (0.0792) |
0.00666 (0.426) |
1e-05 (0.00096) |
0.00515 (0.34) |
del 3p22 2 | 14 (11%) | 109 |
4e-05 (0.00332) |
1e-05 (0.00096) |
0.025 (1.00) |
0.013 (0.779) |
0.0237 (1.00) |
0.065 (1.00) |
0.00056 (0.0414) |
0.0287 (1.00) |
del 9p21 3 | 11 (9%) | 112 |
0.0155 (0.913) |
0.00427 (0.286) |
4e-05 (0.00332) |
1e-05 (0.00096) |
0.56 (1.00) |
0.00018 (0.0137) |
0.142 (1.00) |
0.0164 (0.95) |
del 11q22 1 | 7 (6%) | 116 |
6e-05 (0.00474) |
1e-05 (0.00096) |
0.0252 (1.00) |
0.00847 (0.534) |
0.0329 (1.00) |
0.114 (1.00) |
0.00236 (0.165) |
0.0088 (0.546) |
del 19p13 11 | 5 (4%) | 118 |
0.259 (1.00) |
0.045 (1.00) |
0.00296 (0.204) |
0.0004 (0.03) |
0.725 (1.00) |
0.00528 (0.343) |
0.575 (1.00) |
0.17 (1.00) |
del 7q36 3 | 3 (2%) | 120 |
0.0608 (1.00) |
0.176 (1.00) |
0.00101 (0.0737) |
0.00412 (0.28) |
0.651 (1.00) |
0.117 (1.00) |
0.104 (1.00) |
0.621 (1.00) |
del 22q12 1 | 19 (15%) | 104 |
1e-05 (0.00096) |
0.0127 (0.774) |
0.0199 (1.00) |
0.13 (1.00) |
0.248 (1.00) |
0.457 (1.00) |
0.523 (1.00) |
0.428 (1.00) |
del 22q13 32 | 15 (12%) | 108 |
2e-05 (0.00168) |
0.0856 (1.00) |
0.0676 (1.00) |
0.0194 (1.00) |
0.209 (1.00) |
0.297 (1.00) |
0.196 (1.00) |
0.899 (1.00) |
del 2q37 1 | 5 (4%) | 118 |
0.258 (1.00) |
0.0459 (1.00) |
0.67 (1.00) |
0.317 (1.00) |
1 (1.00) |
0.02 (1.00) |
1 (1.00) |
0.17 (1.00) |
del 9q22 33 | 3 (2%) | 120 |
0.598 (1.00) |
0.176 (1.00) |
0.0334 (1.00) |
0.0325 (1.00) |
0.196 (1.00) |
0.0657 (1.00) |
0.107 (1.00) |
0.0596 (1.00) |
del 10q26 3 | 6 (5%) | 117 |
0.627 (1.00) |
0.0393 (1.00) |
0.0746 (1.00) |
0.232 (1.00) |
0.737 (1.00) |
0.0667 (1.00) |
0.858 (1.00) |
0.0483 (1.00) |
P value = 4e-05 (Fisher's exact test), Q value = 0.0033
nPatients | CLUS_1 | CLUS_2 | CLUS_3 |
---|---|---|---|
ALL | 65 | 31 | 27 |
DEL PEAK 2(3P22.2) MUTATED | 1 | 10 | 3 |
DEL PEAK 2(3P22.2) WILD-TYPE | 64 | 21 | 24 |
P value = 1e-05 (Fisher's exact test), Q value = 0.00096
nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 |
---|---|---|---|---|
ALL | 39 | 36 | 24 | 24 |
DEL PEAK 2(3P22.2) MUTATED | 0 | 3 | 10 | 1 |
DEL PEAK 2(3P22.2) WILD-TYPE | 39 | 33 | 14 | 23 |
P value = 0.00056 (Fisher's exact test), Q value = 0.041
nPatients | CLUS_1 | CLUS_2 | CLUS_3 |
---|---|---|---|
ALL | 18 | 59 | 46 |
DEL PEAK 2(3P22.2) MUTATED | 0 | 2 | 12 |
DEL PEAK 2(3P22.2) WILD-TYPE | 18 | 57 | 34 |
P value = 1e-05 (Fisher's exact test), Q value = 0.00096
nPatients | CLUS_1 | CLUS_2 | CLUS_3 |
---|---|---|---|
ALL | 65 | 31 | 27 |
DEL PEAK 3(6P25.2) MUTATED | 1 | 20 | 5 |
DEL PEAK 3(6P25.2) WILD-TYPE | 64 | 11 | 22 |
P value = 1e-05 (Fisher's exact test), Q value = 0.00096
nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 |
---|---|---|---|---|
ALL | 39 | 36 | 24 | 24 |
DEL PEAK 3(6P25.2) MUTATED | 2 | 6 | 15 | 3 |
DEL PEAK 3(6P25.2) WILD-TYPE | 37 | 30 | 9 | 21 |
P value = 0.00149 (Fisher's exact test), Q value = 0.11
nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 |
---|---|---|---|---|
ALL | 43 | 30 | 13 | 29 |
DEL PEAK 3(6P25.2) MUTATED | 14 | 4 | 6 | 1 |
DEL PEAK 3(6P25.2) WILD-TYPE | 29 | 26 | 7 | 28 |
P value = 6e-05 (Fisher's exact test), Q value = 0.0047
nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 |
---|---|---|---|---|
ALL | 44 | 41 | 20 | 10 |
DEL PEAK 3(6P25.2) MUTATED | 15 | 4 | 0 | 6 |
DEL PEAK 3(6P25.2) WILD-TYPE | 29 | 37 | 20 | 4 |
P value = 0.0011 (Fisher's exact test), Q value = 0.079
nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 | CLUS_5 |
---|---|---|---|---|---|
ALL | 58 | 61 | 1 | 2 | 1 |
DEL PEAK 3(6P25.2) MUTATED | 20 | 5 | 0 | 1 | 0 |
DEL PEAK 3(6P25.2) WILD-TYPE | 38 | 56 | 1 | 1 | 1 |
P value = 1e-05 (Fisher's exact test), Q value = 0.00096
nPatients | CLUS_1 | CLUS_2 | CLUS_3 |
---|---|---|---|
ALL | 18 | 59 | 46 |
DEL PEAK 3(6P25.2) MUTATED | 1 | 5 | 20 |
DEL PEAK 3(6P25.2) WILD-TYPE | 17 | 54 | 26 |
P value = 1e-05 (Fisher's exact test), Q value = 0.00096
nPatients | CLUS_1 | CLUS_2 | CLUS_3 |
---|---|---|---|
ALL | 65 | 31 | 27 |
DEL PEAK 4(6Q21) MUTATED | 0 | 18 | 2 |
DEL PEAK 4(6Q21) WILD-TYPE | 65 | 13 | 25 |
P value = 1e-05 (Fisher's exact test), Q value = 0.00096
nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 |
---|---|---|---|---|
ALL | 39 | 36 | 24 | 24 |
DEL PEAK 4(6Q21) MUTATED | 1 | 3 | 16 | 0 |
DEL PEAK 4(6Q21) WILD-TYPE | 38 | 33 | 8 | 24 |
P value = 1e-05 (Fisher's exact test), Q value = 0.00096
nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 |
---|---|---|---|---|
ALL | 43 | 30 | 13 | 29 |
DEL PEAK 4(6Q21) MUTATED | 13 | 0 | 7 | 0 |
DEL PEAK 4(6Q21) WILD-TYPE | 30 | 30 | 6 | 29 |
P value = 1e-05 (Fisher's exact test), Q value = 0.00096
nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 |
---|---|---|---|---|
ALL | 44 | 41 | 20 | 10 |
DEL PEAK 4(6Q21) MUTATED | 14 | 0 | 1 | 5 |
DEL PEAK 4(6Q21) WILD-TYPE | 30 | 41 | 19 | 5 |
P value = 4e-05 (Fisher's exact test), Q value = 0.0033
nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 | CLUS_5 |
---|---|---|---|---|---|
ALL | 58 | 61 | 1 | 2 | 1 |
DEL PEAK 4(6Q21) MUTATED | 18 | 1 | 0 | 1 | 0 |
DEL PEAK 4(6Q21) WILD-TYPE | 40 | 60 | 1 | 1 | 1 |
P value = 0.00015 (Fisher's exact test), Q value = 0.012
nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 | CLUS_5 | CLUS_6 |
---|---|---|---|---|---|---|
ALL | 27 | 18 | 28 | 7 | 16 | 27 |
DEL PEAK 4(6Q21) MUTATED | 9 | 0 | 7 | 3 | 1 | 0 |
DEL PEAK 4(6Q21) WILD-TYPE | 18 | 18 | 21 | 4 | 15 | 27 |
P value = 1e-05 (Fisher's exact test), Q value = 0.00096
nPatients | CLUS_1 | CLUS_2 | CLUS_3 |
---|---|---|---|
ALL | 18 | 59 | 46 |
DEL PEAK 4(6Q21) MUTATED | 0 | 0 | 20 |
DEL PEAK 4(6Q21) WILD-TYPE | 18 | 59 | 26 |
P value = 5e-05 (Fisher's exact test), Q value = 0.004
nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 |
---|---|---|---|---|
ALL | 29 | 33 | 33 | 28 |
DEL PEAK 4(6Q21) MUTATED | 10 | 1 | 9 | 0 |
DEL PEAK 4(6Q21) WILD-TYPE | 19 | 32 | 24 | 28 |
P value = 0.00101 (Fisher's exact test), Q value = 0.074
nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 |
---|---|---|---|---|
ALL | 43 | 30 | 13 | 29 |
DEL PEAK 5(7Q36.3) MUTATED | 0 | 0 | 3 | 0 |
DEL PEAK 5(7Q36.3) WILD-TYPE | 43 | 30 | 10 | 29 |
P value = 4e-05 (Fisher's exact test), Q value = 0.0033
nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 |
---|---|---|---|---|
ALL | 43 | 30 | 13 | 29 |
DEL PEAK 6(9P21.3) MUTATED | 1 | 3 | 6 | 0 |
DEL PEAK 6(9P21.3) WILD-TYPE | 42 | 27 | 7 | 29 |
P value = 1e-05 (Fisher's exact test), Q value = 0.00096
nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 |
---|---|---|---|---|
ALL | 44 | 41 | 20 | 10 |
DEL PEAK 6(9P21.3) MUTATED | 1 | 0 | 3 | 6 |
DEL PEAK 6(9P21.3) WILD-TYPE | 43 | 41 | 17 | 4 |
P value = 0.00018 (Fisher's exact test), Q value = 0.014
nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 | CLUS_5 | CLUS_6 |
---|---|---|---|---|---|---|
ALL | 27 | 18 | 28 | 7 | 16 | 27 |
DEL PEAK 6(9P21.3) MUTATED | 0 | 0 | 3 | 4 | 3 | 1 |
DEL PEAK 6(9P21.3) WILD-TYPE | 27 | 18 | 25 | 3 | 13 | 26 |
P value = 6e-05 (Fisher's exact test), Q value = 0.0047
nPatients | CLUS_1 | CLUS_2 | CLUS_3 |
---|---|---|---|
ALL | 65 | 31 | 27 |
DEL PEAK 9(11Q22.1) MUTATED | 0 | 7 | 0 |
DEL PEAK 9(11Q22.1) WILD-TYPE | 65 | 24 | 27 |
P value = 1e-05 (Fisher's exact test), Q value = 0.00096
nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 |
---|---|---|---|---|
ALL | 39 | 36 | 24 | 24 |
DEL PEAK 9(11Q22.1) MUTATED | 0 | 0 | 7 | 0 |
DEL PEAK 9(11Q22.1) WILD-TYPE | 39 | 36 | 17 | 24 |
P value = 0.00236 (Fisher's exact test), Q value = 0.17
nPatients | CLUS_1 | CLUS_2 | CLUS_3 |
---|---|---|---|
ALL | 18 | 59 | 46 |
DEL PEAK 9(11Q22.1) MUTATED | 0 | 0 | 7 |
DEL PEAK 9(11Q22.1) WILD-TYPE | 18 | 59 | 39 |
P value = 0.00296 (Fisher's exact test), Q value = 0.2
nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 |
---|---|---|---|---|
ALL | 43 | 30 | 13 | 29 |
DEL PEAK 10(19P13.11) MUTATED | 0 | 2 | 3 | 0 |
DEL PEAK 10(19P13.11) WILD-TYPE | 43 | 28 | 10 | 29 |
P value = 4e-04 (Fisher's exact test), Q value = 0.03
nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 |
---|---|---|---|---|
ALL | 44 | 41 | 20 | 10 |
DEL PEAK 10(19P13.11) MUTATED | 0 | 0 | 2 | 3 |
DEL PEAK 10(19P13.11) WILD-TYPE | 44 | 41 | 18 | 7 |
P value = 1e-05 (Fisher's exact test), Q value = 0.00096
nPatients | CLUS_1 | CLUS_2 | CLUS_3 |
---|---|---|---|
ALL | 65 | 31 | 27 |
DEL PEAK 11(22Q12.1) MUTATED | 0 | 4 | 15 |
DEL PEAK 11(22Q12.1) WILD-TYPE | 65 | 27 | 12 |
P value = 2e-05 (Fisher's exact test), Q value = 0.0017
nPatients | CLUS_1 | CLUS_2 | CLUS_3 |
---|---|---|---|
ALL | 65 | 31 | 27 |
DEL PEAK 12(22Q13.32) MUTATED | 1 | 4 | 10 |
DEL PEAK 12(22Q13.32) WILD-TYPE | 64 | 27 | 17 |
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Copy number data file = transformed.cor.cli.txt
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Molecular subtype file = THYM-TP.transferedmergedcluster.txt
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Number of patients = 123
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Number of significantly focal cnvs = 12
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Number of molecular subtypes = 8
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Exclude genes that fewer than K tumors have alterations, K = 3
For binary or multi-class clinical features (nominal or ordinal), two-tailed Fisher's exact tests (Fisher 1922) were used to estimate the P values using the 'fisher.test' function in R
For multiple hypothesis correction, Q value is the False Discovery Rate (FDR) analogue of the P value (Benjamini and Hochberg 1995), defined as the minimum FDR at which the test may be called significant. We used the 'Benjamini and Hochberg' method of 'p.adjust' function in R to convert P values into Q values.
In addition to the links below, the full results of the analysis summarized in this report can also be downloaded programmatically using firehose_get, or interactively from either the Broad GDAC website or TCGA Data Coordination Center Portal.